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    <name>A0A0D2MLL5_GOSRA</name>
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    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="9">Cytoplasm</location>
            <location evidence="9">Cytoskeleton</location>
            <location evidence="9">Phragmoplast</location>
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        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle pole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
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    <dbReference type="GO" id="GO:0010005">
        <property type="term" value="C:cortical microtubule, transverse to long axis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Calponin-like domain"/>
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        <property type="entry name" value="CH_dom"/>
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    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
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    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
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    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="12">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="13">
        <location>
            <begin position="179"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060413"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00083920"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJB19327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="275" mass="30855" checksum="4A24679F7FF6560E" modified="2015-04-29" version="1">MASNIGMMDSAYFVGRNEILTWINNRLQLNLSRIEEAASGAVQCQMIDMTYPGAVPMHKVNFDAKSEYDMIQNYKVLQEVFNKLKIDKHIEVNRLVKGRPLDNLEFLQWLKRYCDSVNGGIMNENYDPVERRLKGGKERNLKGSLKSSKSLQANNLHNLASGDAAGINKNTVSKQGKTGVAAASSEVRALSKEITDLKLSVDLLEKERDFYFAKLRDIEILCQSTKVENHPMAVAIKKILYAADAKESALDEAQEFISQSVDNGETEEANEEETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MSU7</accession>
    <name>A0A0D2MSU7_GOSRA</name>
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        <submittedName>
            <fullName evidence="11">CONSTANS-like 6 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G030300</name>
        <name evidence="13" type="ORF">Gorai_013992</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0118669" last="E0118669">
            <title>Molecular Evolution and Phylogenetic Analysis of Eight COL Superfamily Genes in Group I Related to Photoperiodic Regulation of Flowering Time in Wild and Domesticated Cotton (Gossypium) Species.</title>
            <authorList>
                <person name="Zhang R."/>
                <person name="Ding J."/>
                <person name="Liu C."/>
                <person name="Cai C."/>
                <person name="Zhou B."/>
                <person name="Zhang T."/>
                <person name="Guo W."/>
            </authorList>
            <dbReference type="PubMed" id="25710777"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="13 15" key="3">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CONSTANS family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="SMR" id="A0A0D2MSU7"/>
    <dbReference type="STRING" id="29730.A0A0D2MSU7"/>
    <dbReference type="Gramene" id="KJB22117">
        <property type="protein sequence ID" value="KJB22117"/>
        <property type="gene ID" value="B456_004G030300"/>
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    <dbReference type="KEGG" id="gra:105790222"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045281">
        <property type="entry name" value="CONSTANS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31319:SF53">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="22"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="9">
        <location>
            <begin position="59"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="10">
        <location>
            <begin position="235"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AJR28811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB22117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0583119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="313" mass="34241" checksum="7BD75EA97666B8F3" modified="2015-04-29" version="1">MGIEISGGTIIPGGWGAAAMAVAAKTCDACKSSAAAIFCRTDWVFLCLNCDSNFHSGHERVSMCEVCEQAPAAVTCKADAAALCVTCDADIHSANPLARRHERVPIEPFYDSADSIVKSSPFSFLVPTTDHNGTNCKQEIESNKGDFFFTEMDRFIDFGYPNSSQHLHDAAMDSVVPVQTPKPVIPLINDGSCFDTFSYQTQSSLSHSVSSSSLEVGTVPDGNYHATQVGGSIDREARVLRYKEKRKNRKFEKTIRYASRKAYAESRPRIKGRFAKRTETHNDDVDHMFNNSSFAVGPAGFMAETDYGVVPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NBQ6</accession>
    <name>A0A0D2NBQ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G197000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NBQ6"/>
    <dbReference type="Gramene" id="KJB10348">
        <property type="protein sequence ID" value="KJB10348"/>
        <property type="gene ID" value="B456_001G197000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800330"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFMFSEY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23116">
        <property type="entry name" value="RING-H2_AIRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000359">
        <property type="entry name" value="E3 ubiquitin-protein ligase At3g02290-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463:SF86">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46463">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB10348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="226" mass="25405" checksum="457E0FBD04605A83" modified="2015-04-29" version="1">MGSVCCCLRPEDFEDYINPNSNVYRNCVCLSCFVQNFVHVYTTLFRRGELRSVPSSIQGTGSIISSASLDNSLSDMYQSPPRPLPYDAEARYFRLQRDGLVSRHEKGSSQSHEESEPLRGENDADPGSLSTEGKWNAFERGSKEQHSKSSQKLSSAKAPVGIGYIYSSAEEEEDVCPTCLEEYTPENPKIITKCSHHFHLGCIYEWMERSENCPVCGKVMVFDETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJJ4</accession>
    <name>A0A0D2NJJ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G076800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJJ4"/>
    <dbReference type="STRING" id="29730.A0A0D2NJJ4"/>
    <dbReference type="Gramene" id="KJB13468">
        <property type="protein sequence ID" value="KJB13468"/>
        <property type="gene ID" value="B456_002G076800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF110">
        <property type="entry name" value="MSP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="3">
        <location>
            <begin position="72"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB13468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="264" mass="29834" checksum="BD354959D1B65268" modified="2015-04-29" version="1">MAIVDRHQRSSERKMFSLCPFWQTSTTMNNSSSSSSTKNLNHNGSRHSETVAAKRSKTVSSIARSLLPPRRRLRLDPSNKLYFPYEPGTQARSAIRLKNTSKSHVAFKFQTTAPKSCFMRPPGGILAPGESIIATVFKFVERPENNEVQVDLKSKVKFKIMSLKVTAGVDYLPELFDEQRDQVTIERILRVVFLDMGRPSPALDKLKRQLAEAEAAFEARKKPAPDTGPRVVGEGLVIDEWVIDCLYVLNHASFSFSSFLFYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NLI9</accession>
    <name>A0A0D2NLI9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7950 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G039600</name>
        <name evidence="4" type="ORF">Gorai_000285</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NLI9"/>
    <dbReference type="STRING" id="29730.A0A0D2NLI9"/>
    <dbReference type="Gramene" id="KJB33942">
        <property type="protein sequence ID" value="KJB33942"/>
        <property type="gene ID" value="B456_006G039600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLEIDTC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057710">
        <property type="entry name" value="DUF7950"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33595:SF10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33595">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25821">
        <property type="entry name" value="DUF7950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7950" evidence="2">
        <location>
            <begin position="162"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB33942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0587150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="300" mass="34038" checksum="3929483A2BCACAEF" modified="2015-04-29" version="1">MNGEEKRSKVSYRGGAPDKTVINPIMLRFRPIAPKPVSGEPGSDGVRFDNKNMLLCNPRAKRKYVRVRKKNMRRKKRSSSDQLHHDEASNNPQTIVTLQLLPEKTEGNGSINNQNGRVLGENQDPLYLCNLNFNNCWVDRLGVVEEPNRTVLMSQTRKATVVESWVTVESVTDSCMEVRQLGSTDVEMIKNLEIDTCPGFISDGLNRVQWVNGAYKRMLMVVGEANDGRPPPEIMVWLVFKQELPRFCTAFSCKVRLQYTWQKEKFSRMLPCDVWKMDGSGGVGCLAWRLDVEAALSLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NNK6</accession>
    <name>A0A0D2NNK6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G155400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NNK6"/>
    <dbReference type="STRING" id="29730.A0A0D2NNK6"/>
    <dbReference type="Gramene" id="KJB14988">
        <property type="protein sequence ID" value="KJB14988"/>
        <property type="gene ID" value="B456_002G155400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785439"/>
    <dbReference type="eggNOG" id="ENOG502RERW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHDSVKC"/>
    <dbReference type="OrthoDB" id="276388at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37217">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37217:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="30588" checksum="22071898B09540A8" modified="2015-04-29" version="1">MGSLLVPSPLLLPSLSRSFLPKLQSQPQYISPRISLCNQYPFRLSFQSSFPRKSLCSHRSLAGAFNTSSEGTVSVINIEDFNEKDWSFLDSEELNSEQAKRNIDRITSAGEISESSRVLVSVGSEGFVDHLVESSNTQLLLVVHDSIFFLAGIKEQYDEVKCWQGELIYVPEKWTPFDVIFLYFLPALPIELDQIFAALAKRCSSGARVVISHPQGREVLEQQRKEFPDIVNGNLPDKTTLQKVAADHSFEMTEFVDEPGFYLAVLKFSEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NP85</accession>
    <name>A0A0D2NP85_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G171500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NP85"/>
    <dbReference type="STRING" id="29730.A0A0D2NP85"/>
    <dbReference type="Gramene" id="KJB15328">
        <property type="protein sequence ID" value="KJB15328"/>
        <property type="gene ID" value="B456_002G171500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704:SF37">
        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="250" mass="28394" checksum="F1CC19A1ADA2D748" modified="2015-04-29" version="1">MWDKRLTEKFCDICIKEILKGNRPGTHFTKDGWLKIMTNFEKETGKGFHKDNLKIGEDTGLGWNPIKRTVDTSDEWWEIVPEAKKFRISGIDPEFEGKLDQMFIGIVATGDKAWAPSSSTLRSDFFEDVNNEIPEEKKNPEMPSSHFKTGRKKSSKQIGGAARLSSQIEKLCNAADNMSQATSSLTSVMDPYGIPQAVKMLDSMSEEVPEASSLYFFALRLLLNKDKRIMFLSINPKIRALWLKTEMKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NTW2</accession>
    <name>A0A0D2NTW2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G184600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NTW2"/>
    <dbReference type="Gramene" id="KJB17358">
        <property type="protein sequence ID" value="KJB17358"/>
        <property type="gene ID" value="B456_003G184600"/>
    </dbReference>
    <dbReference type="OMA" id="MSIELLW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="69" mass="8271" checksum="FAF8B7BBCD07168D" modified="2015-04-29" version="1">MHDNHRSCIVVSVCWIKISGGISCYTIYGLCMVMSIELLWICVFRMLMSSQRLRIYSIRWPRRALRCQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NV33</accession>
    <name>A0A0D2NV33_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Histone-lysine N-methyltransferase SUVR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_003G018700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2NV33"/>
    <dbReference type="Gramene" id="KJB17843">
        <property type="protein sequence ID" value="KJB17843"/>
        <property type="gene ID" value="B456_003G018700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040689">
        <property type="entry name" value="SUVR5_Znf-C2H2_3rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47325">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUVR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47325:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUVR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18868">
        <property type="entry name" value="zf-C2H2_3rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002260054" description="Histone-lysine N-methyltransferase SUVR5" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="1041"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-SET" evidence="11">
        <location>
            <begin position="1356"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="10">
        <location>
            <begin position="1435"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="12">
        <location>
            <begin position="1574"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB17843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1590" mass="179710" checksum="E2D728CAC0D035D6" modified="2015-04-29" version="1">MYIQFSVYILTRFLLQHLTLAWIELCLDSKVILGDNQCLYAHYTALEIPGCIMEVLPCSGVQYVADSDCAQLSPEATFTYDRESNCLEQKKQVQVADSRMDDLLLTNEGNQEGRQDEGQGTRVELPISEDHHSGSSYYDCQAEGQRLSCGSHDDEYDDLNAQNCCTGPYLTSENSHVLVNTIESESPINNREGELSLSEPKWLEHDESVALWVKWRGKWQAGIRCARADWPLSTLKAKPTHDRKQYFVIFFPHTRNYSWADMLLVRSISEFPQPIAYRSHKVGLKMVRDLTVARRYIQQKLAVGMLNIIDQFHVEALIEAARNVVVWKDFAMEASRCNGYSDLGKMLLKLQTMILPCYINAEWLQESLHSWVQQCQNAHSAESVELLKEELYDAILWNEVKSLGDASVQPTLGSEWKTWKHEVMKWFSTSHPVSSAGDVNQRSSDGLSNTNIQVSRKRAKLEVRRADTHASMVQSNGSDQTMAVEIDSDFFSNRDAVDVNLPTPQHCKKEDEREETTPMDTSNSLTDRWNNIVVEARHPEVIHTKNVEITTASEEVKTTSTLHIQPKEVELTPVNEAVAKKSIDSGSKNRQCTAFIESKGRQCVRWANEGDVYCCVHLASRFTGSFSKIEATPAVDTPMCEGTTVLGTRCKHRSLYGSSFCKKHRPKSDVNNSSHSPEHTQKRKHLEIIQSSETTLCRDIVLVGDNESPLQVEPVSVIEADALHRGNSLIEKPEHSGKDHDGTELMHCIGLYSNNGFDPCQESPKRHSLYCDKHLPSWLKRARNGKSRIVSREVFVDLLKDCDSLEQKLHLHQACELFYKLFKSILSLRNPVPVDVQLQWALSEASKDFRVGELLMKLVYSEKERLQSLWGFTGDKGTPSSSFMEEPVPLPLAINDSFDDDKTIKCKMCSVEFLDDQQLGTHWMENHKKEAQRLFRGYACAICLDSFINKKVLESHVQERHHVQFVEQCMLLRCISCGSHFGNTEELWLHVLSTHPVDFRLSKIALQHNPSAGEEPPLKLELGNSASLENNSENVGSVQKFICRFCGLKFDLLPDLGRHHQAAHMGPSLASSRPPKKGVRYYAYKLKSGRLSHPRFKKGLGAVSYRIRNRATATMKKRLQASKLIDAEIISAEPHVMENSNLGRLAEPQCSALAKILFSRTHKTKPRPNNLDILSIARSSCCKVSLKASLEEKYGMLPECLYLKAAKLCSEHNVQVEWHQEKFVCINGCKPAKDPDFLSPLIPLPNGFEGCQSADSLDDADEELELDECHYIIDSQHFKKGPMQKASILCDDLSFGKESVPVACVVDEGLFDSVYISGLSSNEQNARSSMPWENFIYVTNSSLDQSLDLDVESVQLGCTCSNSTCFPETCDHVYLFDNDYEDARDVFGKPMRGRFPYDDKGRIILEEGYLVYECNRKCSCNIACPNRVLQKGVRVKLEVFKTENKGWGVRAGEPILSGTFVCEYVGEILGEQEANNRLTRYGRDGCNYMFNIGSQINDMSRLIEGQARYFIDASKYGNVSRFINHSCSPNLVNHQVLVDSMDCHRAHIGLYASQDISVGEELTFDYRYELLPGQGYPCQCGASTCRGRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NVQ0</accession>
    <name>A0A0D2NVQ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein ACR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein ACT DOMAIN REPEATS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G031800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds amino acids.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NVQ0"/>
    <dbReference type="STRING" id="29730.A0A0D2NVQ0"/>
    <dbReference type="Gramene" id="KJB18058">
        <property type="protein sequence ID" value="KJB18058"/>
        <property type="gene ID" value="B456_003G031800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18059">
        <property type="protein sequence ID" value="KJB18059"/>
        <property type="gene ID" value="B456_003G031800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18060">
        <property type="protein sequence ID" value="KJB18060"/>
        <property type="gene ID" value="B456_003G031800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQHS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDAYQDC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04895">
        <property type="entry name" value="ACT_ACR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04897">
        <property type="entry name" value="ACT_ACR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040217">
        <property type="entry name" value="ACR1-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096:SF7">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB18058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="487" mass="55046" checksum="47F2191B45095959" modified="2015-04-29" version="1">MENVYQPYIDPEVQSLLDRIHPPRVCIDNDAFHDCTLVKVDSANRHGILLEMVQVLTDLDLVISKSYVSSDGGWLMDVFHVTDHLGSKVTDETLILYIQQALTDPRRRGEIPKELQTCLTRDVKPCHVSTEHTALETTGRDRPGLMSEISAALYELRCHVTAAVAWTHNARVACIIHIEDGLMRGPIMASKKLAQAHEKLKSVVEAHHESGERWSVRLTAPAVGRTHTERRLHQLMYADRDYKQCQGSDGSCRQWNGCTNTHVTIEACREKGYLVVNIRCRDRTKLLFDTVCALTDMQYVVFHAAISSKGTMADQEYFIRRQDGFSSNTQSEREKLAQCLIAAIERRESHGLRLDICTQNKMGLLSDVTRVFRENGLSITRVEIGTQGERATGTFHVTDASGHEADLRTVELVRQEIGGSVLRVYRSPNGTSRASSSSISRNSSGEVEERAKFSLGNLLWSQLERFRRILGSLNHKQFLIMYIIHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NXK4</accession>
    <name>A0A0D2NXK4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">FAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G236700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the fantastic four family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NXK4"/>
    <dbReference type="STRING" id="29730.A0A0D2NXK4"/>
    <dbReference type="Gramene" id="KJB38097">
        <property type="protein sequence ID" value="KJB38097"/>
        <property type="gene ID" value="B456_006G236700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVU6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EIGIVNC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021410">
        <property type="entry name" value="FAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046431">
        <property type="entry name" value="FAF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155">
        <property type="entry name" value="FANTASTIC FOUR-LIKE PROTEIN (DUF3049)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33155:SF4">
        <property type="entry name" value="PROTEIN FANTASTIC FOUR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11250">
        <property type="entry name" value="FAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAF" evidence="3">
        <location>
            <begin position="121"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB38097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="258" mass="28644" checksum="69ADB91959026B1C" modified="2015-04-29" version="1" fragment="single">ALRLTLSSARPRELISKSCSVNPEPGGWSLLQALFNSPQSSKGEQGNENTYVHPLVKRSLSSLSEKSLELCTENLGSETGSDEVLEDDVFALSSHSSQGGNPPTWKSGQPLGSTKKAIAGDFPPPLTTISGSESLRVRSHRENGRLVIQAVKAPSNNPIFQAERSNGRLRLHLLKYSTSSIDHEEEKTADVENDNNTNNNENDDEEEQEEEYENDDNYIAEEEEPEKEEDGETATLQRSWDGRGRYYCKEGETEKRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P028</accession>
    <name>A0A0D2P028_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G290400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB39007">
        <property type="protein sequence ID" value="KJB39007"/>
        <property type="gene ID" value="B456_007G290400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMDSFHE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF172">
        <property type="entry name" value="DOMAIN-CONTAINING DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="174"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB39007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="2107" mass="239958" checksum="03E91BC2CAC686CE" modified="2015-04-29" version="1">MDTIFTGAAHEVTTAAAKGIFRQAIRHIRYVIFYQKFVAEFEKEKKNLNIERTSVQEDVAFALANLENIKTNVQEWRHKVDEIFTEEAKKVNDLEVKAKTKCFFGLCPNIKSRYQLSKKAEEDAANFKKLIDDGRFERVGCPYVAEPIIHTDFETFQSREEVFHDIMELLKDATTSMIGVYGMPGVGKSWLVNEVERQLREVKLFDSVVTVIARQNADIKEIVEVASFEACSTRYLLSLLDSIVAPTEIQNQIAYSLRLKLEENSPGVRARKLYERLKNEKNVLIILDDLWKKLDLKEVGIPFGSQYKGCKILLTSRYQNVLNNGEDATKTFAIGDLDGEEAWEFFKKMAGDIVESDEELRSTAIEVAKKCAKLPLALATVARSLRNKPLFFWRDALQQLQRPCLEKSSDDISDKVYSAIKYSIDHLSSEDLKQIFLLCSLLRRDTRIEDLLRYALALGLIKGANSMKAARDRLLKMLSTLKESCLLLDSKSSNKEYFDVHDLTYIVAKSIASKDNQVLALTEEDKDEDEDVVTDWRTGESMKECNKVILRDPSINELPDQLNSPQLFLFLLLSKDLSLTLPDNFFKEAKNLKVLGLTCMHFSPLPSSIGLLTSLSTLCLDHCNLGDNLTIIGALKSLNVLSLAGSDVKIVPKEIGHLLKLKLLDVSGCTKLKTISADVLPSLSKLEELYMGGTSIQWGQPNASLAELNTLSHLSTLEVQIPNAKAAPEDFFQKLQKLERYRICIGKEWERFGNYQYSRTLKLRLNTSIDDLDHGIKKLAKRTQDLQLDELKGVKIALEELTDLERLLHLQNLHIQNGLDIESIINDRNEFPQLQTLTLEGLPQLVSFCCQDKIDGTSLPQRELPLFGEKVAFPSLEEMSVSYLSKMKMLWRNPLPPNSFPKLQELRVEKCDKLLTIFPSNMVTTFQRLQRLTIKTCGSLQQVFEIVHEEKKPALPPITQLKKLHIVGLPKLKYIWKNDPRVIFSFKNICSISVFDCPSLKNVFPASIAQDLPQLGYLHIFLCGVEEIVSKLGEGSDWEATVNFKFDRLCTLALSNLPKLKCFYPGKHIAKWPMLNKLEVVGCGKMKIFGTQVNTNNGQLDSSIPPPLFLVEKIIPKLQHLTLDSDYIAMISDGQFSSSHFHEIKTFEVSGGGAEPIDFRISFLERFYTLENLTISCNIKELFCTEGDTGNEEIYAGTLSTIRNLKLERLNNLKDYLWKQDAQVGQILPKLETLEVHDCYNLISLGSSSASFQNLTTLDVSNCKTMKYLDTCLVFQGMAQLKKLMVRDCISMKEIVATEGDEATSDIIFSSLKSLELVNLPRLKSFCSGNHTFGFPCLEELVVNGCLELEIFCKGVLTNPPLLQKIEYGKGKGHWCSDLNNTIQEMYSIKAGFQAIEYLVLSEFSRSIEIWKENIHGSIDFKKLKVLEVYGCNTMTYIFSVSMALDLSQLVDIKVKQCPMMKQIIKKGAEETEMDTLLLPMLKWITLESCSRLTSFCMGSITLRCSSLLKIVVDDCPKMYAMASTREQEDIEEVGREKTPFFNHKVLCARLQLLKLSSTNIKKLWPDKPDWAISPGVLNLEFLLVKGCHNLEYLFPSFLVKNFEQLDTLILRDCKNMEEIIFTDGLAAATDEEIPQTFLFTKLQILELNRLPKLRTFCHQENSEINTLFNQKVAFPSLVELTIVGMGKCRKIWHDKLTMDSFHELTLLLVEHCDKLSNVFPFNMVERLEKLETLQILECESVEEIIGLADDHGLSSNETIELKSTTKFVFPKIRNLVLYKLPKLKGFYSKVHTTDWPLLKLLEVRECSKVETFAGGYINLRETQGESQPIISVPQPLFWVTKETFPNLEELVLDGNGNMKSFCSCNHAFGFSCLEKFVVRTFEGLRQLSLLDCENLEEIIFTDGLATVAEEGIPQTYLFSKLQKLELNRLPKLRTFCHQENSETNTLFNQKVAFPSLDDLRIVGVGKCRKIWQDKLTMDSFHELTLLLVEHCDKLLRVLPYDMVERLEKLNILEISECESVEEIIGHNSNESIELKSTTKFMFPKIRQLILRKLPKLKGFYSKVHTTDWPLLKQLEVHECSKVETFSGEYINCRETQGESQPVISVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PBU1</accession>
    <name>A0A0D2PBU1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G142900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PBU1"/>
    <dbReference type="STRING" id="29730.A0A0D2PBU1"/>
    <dbReference type="Gramene" id="KJB24388">
        <property type="protein sequence ID" value="KJB24388"/>
        <property type="gene ID" value="B456_004G142900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21203">
        <property type="entry name" value="CH_AtKIN14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01366">
        <property type="entry name" value="KISc_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000062">
        <property type="entry name" value="Kinesin-like protein KIN-14I isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000045">
        <property type="entry name" value="Kinesin-like protein KIN-14I isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF39">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-14I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="39"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="11">
        <location>
            <begin position="400"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="827"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="954"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="732"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="844"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="482"/>
            <end position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB24388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112704" checksum="B0D43F97F0358899" modified="2015-04-29" version="1">MAAEGTLSFSVASVVKDVLEHGNRSKDSDLESRKAELTASRRYEAARWLRKMVGVVAAKDLPAEPSEEEFRLGLRSGIILCNVLNKVQPGAVPKVVESPCDAALIPDGAALSVFQYFENVRNFLIAGQELRLPTFEASDLEQRGKSTRVVNCVLALKSYNEWKLAGGNGVWKFGGNTKPATTSLGKPFVRKNSEPFMNSFQKTSSMNENLSNGHPPDIDPNTMGGAGSLSMLVHTILIDKKPEEVPLLVESLLGKVVEEFEQRLASQYEVMKTTSTDITASNFNKPLSEPISGDKKMEEKNIKMMKKDDCFLKSITNDELKDQSLKLQMILNKQQRDIQVLKHTIDATTADMQHMQTKFHEEFNNLGMNIHGLAHAASGYHRVLEENRKLYNQVQDLKGSIRVYCRVRPFLSERSSYVSTVEHIEDGNITIGTPSKYGKGCKSFTFNKVFGQSVTQAEVFSDMQPLIRSVLDGYNVCIFAYGQTGSGKTYTMVGPKDLTEENQGVNYRALGDLFVLAERRKDTFRYDVAVQMIEIYNEQVRDLLVIDGSNKRLEIRNSSQTGLNVPDASLMPVSSTSDVIDLMNLGQRNRAVGATALNDRSSRSHSCLTVHVQGKDLTSGTILRGCMHLVDLAGSERVNKSEVTGDRLKEAQHINKSLSALGDVIASLAQKNTHVPYRNSKLTQLLQDSLGGQAKTLMFVHISPELDALAETLSTLKFAERVATVELGAAQVNKDTADVKQLKEQIASLKAALARKEGETEQSRHSISDTDCSEKYITSSDLFPFTPNHRVGDMLGARQLMGDAGNIEARANSMLRQEKQSFSLDELLTNSPPWPPVISPTQNFRDDEKESGSGEWVDKVMVNKQDNINRVGIPLGCWEAENENSPDVFYQKYLQNSSKIYQEQSSYNMFMGGNRFNMANISDIDDLDVSTSHLSEPDFLWQFDQSKLSCITNGIGIGSKTKKPPSKSTSTPERSKNAYPISGPSPSRKLGNGVGQPLHRNGRQPVPAEGKRKIGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PIL3</accession>
    <name>A0A0D2PIL3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G260600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, pelo recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following ribosome-binding, the Pelota-HBS1L complex promotes the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PIL3"/>
    <dbReference type="STRING" id="29730.A0A0D2PIL3"/>
    <dbReference type="Gramene" id="KJB26793">
        <property type="protein sequence ID" value="KJB26793"/>
        <property type="gene ID" value="B456_004G260600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792700"/>
    <dbReference type="eggNOG" id="KOG2869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000008">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="10">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00054141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB26793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="377" mass="42250" checksum="75597C6BECDCDD7C" modified="2015-04-29" version="1">MKVVHRDLVPNGPGSVKMIPVDSEDLWFAYNLIATGDWVMARTVRKVLRETAGGRDAERVALKLEIKVEAIDYDKEGSVLRIRGKNTLENEHVKIGQFHTLELELQRPFVLRKKIWDSLALDVLRQASDPGASADLAVVLMQEGLANILLVGKSMTSTRSRIETSIPRKHGPAIAGYESALKKFFENVLQAFLKHVDFNVVRCAVIASPGFTKDQFHRHLMLEAERRQLRPIIENKSRIILVHTSSGYKHSLKEVLDAPNVMSMIKDTKAAQEVRALKDFFNMLSNDPARACYGPKHVEVAHERMAVQTLLITDDLFRNSDVITRQKYVGLVNSVKNSGGTAHIFSSMHVSGEQLAQLTGIAAILRFPLPDLEDIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJM0</accession>
    <name>A0A0D2PJM0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G355700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJM0"/>
    <dbReference type="STRING" id="29730.A0A0D2PJM0"/>
    <dbReference type="Gramene" id="KJB46272">
        <property type="protein sequence ID" value="KJB46272"/>
        <property type="gene ID" value="B456_007G355700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761603"/>
    <dbReference type="eggNOG" id="KOG2758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMEPNRP"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000020">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="219"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB46272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="51250" checksum="B6C8A06AB2B36C62" modified="2015-04-29" version="1">MATYDLTPRIGPNLDRHLVFPLLEFLQERQLYPDEQILKAKIELLNKTNMVDYAMDIHKSLYRTDDVPQDMVERRVEVVARLKALEDAAAPLVTFLQNPNAVQELRSDKQYNLQMLNDRYQIGPDQIEALYQYAKFQFECGNYSGAADYLYQYRALCTNSERSLSALWGKLAAEILMQNWDIALEELNRLKEIIDSKSFSSPLNQVQSRIWLMHWSLFIFFNHDNGRTQVIDLFNQDKYLNAIQTSAPHLLRYLATAFIVNKRRRPQFKEFIKVIQQDQCSYKDPITEFLACVYVNYEFDGAQKKMKECEEVILNDPFLGKRVEEGNFNTVPLKDEFLENARLFIFETYCRIHQRIDMGVLFEKLNLNYEEGERWVVNLIRNSKLDAKIDSKTGTVIMEPNRPNVYEQLIDHTKALQGRTYKLVGQLLEHAQAQPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJM8</accession>
    <name>A0A0D2PJM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Disease resistance protein At4g27190-like leucine-rich repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G3561002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJM8"/>
    <dbReference type="Gramene" id="KJB46277">
        <property type="protein sequence ID" value="KJB46277"/>
        <property type="gene ID" value="B456_007G3561002"/>
    </dbReference>
    <dbReference type="OMA" id="MSIEECD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF192">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPS2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="7"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="240"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="372"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="2">
        <location>
            <begin position="515"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB46277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="703" mass="81962" checksum="5111219253BE7632" modified="2015-04-29" version="1" fragment="single">VAFPNFEKITISNLRNTKRIWYNQLHTNSFSILKKLTVKKCDVLLNIFPLFLLRVFQRLEKLVLIDCVSLEEVFQLQVQGLDIEETYVLNSQLREMNLVRLPKLKHVWTKYRKGNISFENLQVVCIHKCWSLKTLFPFSIAKGLQQLEGLTINRCGVEEIVSKNDEGSNNHEICFVFNQLSFLMLWYLPYLTCFYPGKHRTTWPALKHLRMSWLRIKIFGHEKFQIRRPLFLIEKVIPQLEEVSFSHDDIAMISDGQFEADLFCNVKFLRISCYFDVSVVFPISFLRRFYNLERLDVVSCHFKELASFESDACEDKDLIITIPKIKKLKLDMVDNIRHLWKQDSPLDHICASLECLQLWQCDNLINLGLSLSFFETLTILDVWKCNGMSELITSFKVQSLVCLVTMRIRECEMMREVVASDDDETSYEIVFRALKHLELHCLQRLLTFCSGNYTLRFPSLEQITLSQCPRMKNFNQGELTTPKLHKVQLTETDFKGRWAGDLDSTVEQLYKEQVGYLGLKHLKFSEFPKLIDLWSRNPQEMLNFATLEFLEVCDTNNLRCIFNLSTAFSLRQLRQMEIKRCSNLEQVIKEEGSITMVEEAITESCKINSIFPRLQSIIVESCPDMTSFYLGSKGLECPSVVEIKVVDEIKVVDCLNMTTFVSTFSRDEDKEAIIGDEVVNVATLFSNKLLTRDTIQLKHVFTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSC5</accession>
    <name>A0A0D2PSC5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G1006002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSC5"/>
    <dbReference type="STRING" id="29730.A0A0D2PSC5"/>
    <dbReference type="Gramene" id="KJB49096">
        <property type="protein sequence ID" value="KJB49096"/>
        <property type="gene ID" value="B456_008G1006002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB49097">
        <property type="protein sequence ID" value="KJB49097"/>
        <property type="gene ID" value="B456_008G1006002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3325">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB49097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="83" mass="9867" checksum="9F580353DF80E17A" modified="2015-04-29" version="1" fragment="single">EVQDYLKTLCPDLHITRGEYDEDTRYPETKTLTIGQFKLGLCHAMAISADCYLWLHTVYVPFQVERKVTWYVHLSYLHFLQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTT5</accession>
    <name>A0A0D2PTT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G193900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTT5"/>
    <dbReference type="STRING" id="29730.A0A0D2PTT5"/>
    <dbReference type="Gramene" id="KJB10284">
        <property type="protein sequence ID" value="KJB10284"/>
        <property type="gene ID" value="B456_001G193900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13455" checksum="2A8A43FB4FB75F4E" modified="2015-04-29" version="1">MNSLCILARNGLTYPTHDEEAAAKAAAINSDSGAPTIFDKIIAKEIPSTIVYEDDKVLAFKDISLQAPVHVLVIPKFRDGLTQLGKAEQRHGEILGQLLLFDVPLLKLSYASSLASSQPAQPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVF3</accession>
    <name>A0A0D2PVF3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G225600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_001G225600"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF163">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354277" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="28"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="516"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="583"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="659" mass="74398" checksum="B61C2B34D8F766FE" modified="2015-04-29" version="1">MAFSERKMPGICSVFLLVVLFAHSCHGFYLPGSYMHTYSTSDTIVAKVNSLTSIETELPFSYYSLPYCKPLGGIKKSAENLGELLMGDQIDNSPYRFKMNVNESLYVCTTSPLNEHEVKLLKQRTRDLYQVNMILDNLPVMRIAKQNGVSIQWTGFPVGFTPPNSNDDYIINHLKFKVLVHEYEGSGVQIIGTGEEGMGVISEADKKKASGYEIVGFEVTPCSVKYDPEVMTKLHMYDSISPVNCPLELDKSQIIRERERISFTYEVEFVKSDIRWPSRWDAYLKMEGARVHWFSILNSLMVITFLAGIVFVIFLRTVRRDLTRYEELDKEAQAQMNEELSGWKLVVGDVFREPDCAKLLCVMIGDGVQITGMAAVTIVFAAFGFMSPASRGMLLTGMIILYLFLGIAAGYAAVRLWRTLKGTSEGWRSVSWSVACFFPGIVFVILTVLNFILWGSKSTGAIPISLYFVLLSLWFCISVPLTLVGGFLGTRAEAIQYPVRTNQIPREIPARKYPSWLLVLGAGTLPFGTLFIELFFILSSIWLGRFYYVFGFLLIVLLLLIIVCAEVSVVLTYMHLCVEDWRWWWKAFFASGSVALYVFLYSINYLVFDLQSLSGPVSAILYLGYSMIMAIAIMLSTGTIGFITSFYFVHYLFSSVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVN7</accession>
    <name>A0A0D2PVN7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G230500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2PVN7"/>
    <dbReference type="Gramene" id="KJB10884">
        <property type="protein sequence ID" value="KJB10884"/>
        <property type="gene ID" value="B456_001G230500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EVAWAKS"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
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        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
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        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="16"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="327" mass="34420" checksum="36C4B554180493D3" modified="2015-04-29" version="1">MANNLMRAVQYSKYGGGADDLKHVEVLIPSPKKDEVLIKLEAASINPIDWKIQEGVARPFLPRKFPHIPGTDVAGEIVQVGSGVQSFKVGDKVVAVLGNGGALAEYAVAKEGSTVPRPPEVSAPEAAALPIAGLAAHQSLTQLAGLKLDGTGPQVNVLVTAASGGVGQYAVQLAKLANAHVTATCGARNMDLVRSLGADEVLDYKTPDGVALRSPSGRKYDVIIHCAHNIPWSTFEANLTSKGKVVNTTPGICTVMSAAAKTIKCSKKQLIPLFTSPKKENLDFLVNLVKARKLKPIIDSKHPLSKAEVAWAKSIDGHATGKILVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PW67</accession>
    <name>A0A0D2PW67_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G169200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PW67"/>
    <dbReference type="STRING" id="29730.A0A0D2PW67"/>
    <dbReference type="Gramene" id="KJB50407">
        <property type="protein sequence ID" value="KJB50407"/>
        <property type="gene ID" value="B456_008G169200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044821">
        <property type="entry name" value="At1g28695/At4g15970-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46038:SF38">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="1">
        <location>
            <begin position="111"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="398" mass="46576" checksum="8BCD053D109CC924" modified="2015-04-29" version="1">MSPEISKHIRRAALVFTVLTLSALLLYTATDSNRLSSGSFSSSSFATIFPSYLNYSSSSNPTQELEEILKNASMVNNTVILTTLNDAWARTGSIVDLFLKSFMLGDGTRKLLDHLVIVSLDERAYNRCRIVHKHCYALVTKGVGFHQEAYFMTPQYLKMMWRRIDFLRTVLELGYSFVFTDADIMWFRDPFPRFFPDADFQISCDNYLGRPEDMNNSPNGGFNYVKSNSRSIAFYKFWYSSRETYPGYHDQDVLNKIKSDQMITKIGLKIRFLDTAYFGGLCEPSRDLNVVCTMHVNCCIGMDRKLHDLNLMLQDWRAFMSLPPDLKNQSIISWRVPRNCRYFFPSLYIMFYVQLFPFKNGYSLFVNMLQSRSFMAFRFLHLQRWMLKKREKIDWNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0F5</accession>
    <name>A0A0D2Q0F5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">gibberellin 2beta-dioxygenase</fullName>
            <ecNumber evidence="10">1.14.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G038900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>gibberellin A1 + 2-oxoglutarate + O2 = gibberellin A8 + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15005"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58524"/>
            <dbReference type="ChEBI" id="CHEBI:58594"/>
            <dbReference type="EC" id="1.14.11.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.13" evidence="10"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q0F5"/>
    <dbReference type="STRING" id="29730.A0A0D2Q0F5"/>
    <dbReference type="Gramene" id="KJB12844">
        <property type="protein sequence ID" value="KJB12844"/>
        <property type="gene ID" value="B456_002G038900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776050"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCPLINE"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045543">
        <property type="term" value="F:gibberellin 2-beta-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000014">
        <property type="entry name" value="Gibberellin 2-beta-dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="168"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="331" mass="37260" checksum="F2F0B2B1175CAB4D" modified="2015-04-29" version="1">MVVVSKPAIEQFSSYLKNNKPTTLFTQIPLVDLSKPDSKHQIIKACEEFGFFKVINHGVPMESISMLESEATKFFSLPLCEKQKTGQPQPYGYGHKRIGIHGDVGWVEYLLLTTNQDPSLHSFQTFRVALNSYMKSVKKMACEILEMMADGLKIQPRNVLSKLLMDEESDSVFRVNHYPPCPNVQPLNGNGNGNGDVIGFGEHTDPQIISVLRSNNTSGLQISLREGSWISVPPDQTSFFINVGDSLQVMTNGRFKSVKHRVVTNSVKSRLSMIYFCGPPLSEKIAPLPSLMRGDQQSLYKEFTWFEYKKSAYNSRLADNRLIHFEKIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q687</accession>
    <name>A0A0D2Q687_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fibronectin type-III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G004900</name>
        <name evidence="9" type="ORF">Gorai_010784</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0593856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q687"/>
    <dbReference type="STRING" id="29730.A0A0D2Q687"/>
    <dbReference type="Gramene" id="KJB53787">
        <property type="protein sequence ID" value="KJB53787"/>
        <property type="gene ID" value="B456_009G004900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010048">
        <property type="term" value="P:vernalization response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15521">
        <property type="entry name" value="PHD_VIN3_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058585">
        <property type="entry name" value="Fn3_VIN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032881">
        <property type="entry name" value="Oberon-like_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044514">
        <property type="entry name" value="VIN3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056990">
        <property type="entry name" value="VIN3-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286:SF2">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46286">
        <property type="entry name" value="VIN3-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23376">
        <property type="entry name" value="Fn3_VIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07227">
        <property type="entry name" value="PHD_Oberon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23380">
        <property type="entry name" value="VIN3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="7">
        <location>
            <begin position="341"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="449"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="591"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0593856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="717" mass="79508" checksum="8A2EAB557DB23E0A" modified="2015-04-29" version="1">MFCYLAIGVALDPSKCSKLSMDEKRELVYELSKRTSRAPEMLQSWSRQEILQILCAEMGKERKYTGLTKLKIIENLFKIVAEKNSGDHESVMDPEMQSSPTNGQRTAKRQRKADHPCRLPVPVNDFATNNGGDDMTNAIYCKNSACKASLRQEDTFCKRCSCCICYKFDDNKDPSLWLICSSEPPFQGNSCGMSCHLECALKHEKSGFLKDKRHAGLDGIFYCVPCGKVNDLLGCWRKQLMAAKDTRRVDILCYRVSLGQKLLNGTQKYQKLSEIINEAVKKLEAEVGPLTGVPVKMGRGIVNRLSSGPEVQKLCSSAVELLDKMIFDMISNSLPGSSPKPPSIIRFEDVRPTSVTVIVGSEETLPGVNVGYTLCYRKVHDMEYPEKPISTMLVPNMRYVATGLTPATEYRFKIVSFNGTRWEIPISTACIGDEVPSCPVMGISQSPTTNCSSLSNPSSVEDETNNVTPYSDQNDDRADNYLTYCKDTDKIVSTNLCEGGPNTGEVSLLGMDRAIVGPLPDSDVVNVEKKHTLDDPITEDTSTDNGSDALVQIGTECVPFVGCSEAALPVTPCRMEIVKDGQGRSGRSKTSNKDLENQTGNAEDHQDGSSSKKRSGERRDEECVENGLSEMDFKHCVKVIRWLECEGHIEKNFRQKFLTWYSLRATTQEVRVVKVFIDILNADPASLAEQLVDTFSDCISSKKSSVVPAGLCMKLWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8S6</accession>
    <name>A0A0D2Q8S6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G1906002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8S6"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8S6"/>
    <dbReference type="Gramene" id="KJB15679">
        <property type="protein sequence ID" value="KJB15679"/>
        <property type="gene ID" value="B456_002G1906002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDHEMRA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12203">
        <property type="entry name" value="GT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000162">
        <property type="entry name" value="trihelix transcription factor GT-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654">
        <property type="entry name" value="FI21293P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654:SF84">
        <property type="entry name" value="SI:DKEY-66I24.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB15679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="231" mass="26287" checksum="32AB1B2F93D88C37" modified="2015-04-29" version="1" fragment="single">MARDMIIEVTTNGGFPDHLHHHHPHSLQQQQQMILGESSGDDPEVKAPKKRAETWVQDETRSLIGFRKEMDGRFNTSKSNKHLWEKISAMMRKKGFDRSPTMCTDKWRNLLKEFKKAKHPDRGSGSVKMCYYKEIEEILRERTQKSYKAPTPPPKLDSFMHFSDKGLCFEDTSITFGPLEGMLLLLLPSGRPALNIEQGLDYDGHPLAITTANAVAASGVPPWNWRETPGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAX5</accession>
    <name>A0A0D2QAX5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_002G231900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="19">Acts as a catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CCR4/nocturin family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QAX5"/>
    <dbReference type="STRING" id="29730.A0A0D2QAX5"/>
    <dbReference type="Gramene" id="KJB16479">
        <property type="protein sequence ID" value="KJB16479"/>
        <property type="gene ID" value="B456_002G231900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB16480">
        <property type="protein sequence ID" value="KJB16480"/>
        <property type="gene ID" value="B456_002G231900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786258"/>
    <dbReference type="eggNOG" id="KOG0620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRPANTH"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09097">
        <property type="entry name" value="Deadenylase_CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000016">
        <property type="entry name" value="Carbon catabolite repressor protein 4 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="17" id="KW-0804">Transcription</keyword>
    <keyword evidence="16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="20">
        <location>
            <begin position="256"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00054840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="602" mass="66842" checksum="B1FCFD78CE679276" modified="2015-04-29" version="1">MLSVLRVHLPSDIPIVGCELSPYVLLRRPDKTFTTDDVPESAPLDGHFLRYKWYRIQSDRKVAVCSVHPSEQATLQCLGCVKAKIPVAKSYHCSPKCFSDAWQHHRVLHDRAASAVNENGNEEEEIFGRFNSTGAGVISASLTGSASSTSLINGSTPLYPTAVTQRSGGETWFEVGRSKTYTPTTDDIGHVLKFECVVIDAETKLPVGHPNTLLTSRVIPAPSPSPRHLISVGGADMMGQLDSDGRLSSSGTFTVLSYNILSDSYASSELYSYCPSWALSWPYRRQNLLREIVGYRADIVCLQEVQCDHFDEFFAPELDKHGYQALYKRKTNEVYSGNIHTIDGCATFFRRDRFSHVKKYEVEFNKAAQSLTEVAVQTTQKKVALNRLVKDNVALIVVLEAKFTNQGADNPGKRQLLCVANTHVNVQQELKDVKIWQVHTLLKGLEKIAASADIPMLVCGDFNSVPGSAPHSLLAMGKVDPLHPDLLVDPLAILRPHSKLTHQLPLVSAYSAFLRGIGLGSEQQRRRMDPATNEPLFTNCTRDFIGTLDYIFYTADSLTVESLLELLDEDSLRKDTALPSPEWSSDHIALLAEFRCVPKTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QDP7</accession>
    <name>A0A0D2QDP7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">60S acidic ribosomal protein P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G203500</name>
        <name evidence="8" type="ORF">Gorai_001435</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QDP7"/>
    <dbReference type="STRING" id="29730.A0A0D2QDP7"/>
    <dbReference type="Gramene" id="KJB37418">
        <property type="protein sequence ID" value="KJB37418"/>
        <property type="gene ID" value="B456_006G203500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37419">
        <property type="protein sequence ID" value="KJB37419"/>
        <property type="gene ID" value="B456_006G203500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37420">
        <property type="protein sequence ID" value="KJB37420"/>
        <property type="gene ID" value="B456_006G203500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800177"/>
    <dbReference type="eggNOG" id="KOG1762">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB37418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0588325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11305" checksum="EFCB731509530A5E" modified="2015-04-29" version="1">MATGELACTYAALILHDDGISITAEKIATLVKAANLSVESYWPSLFAKLLEKVNVDDLITSVGSGGGAAPVAVAAASGTAGGGAAAAAPAVEEKKEEEKEESDDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QF25</accession>
    <name>A0A0D2QF25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G032600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QF25"/>
    <dbReference type="STRING" id="29730.A0A0D2QF25"/>
    <dbReference type="Gramene" id="KJB18069">
        <property type="protein sequence ID" value="KJB18069"/>
        <property type="gene ID" value="B456_003G032600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787699"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MINIMGR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF9">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="207"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="381"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="451"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="523"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="610"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB18069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="636" mass="72979" checksum="C66E419A1DA64657" modified="2015-04-29" version="1">MRRFSSKSFSLIPKHRFLSLSSYPNTHHFIPSNNDDGFSTSSKPRFGLVTLRTPQPEFEPENDRRVDDFASDVEKIYRILRKFHTRAPKLNLALQQSGVVFRHGLTERVLNRCGDAGNLGYKFFTWASKQPGYHPSYEIYKAMIKILGKMRQFGAVWALLEEIRNENPHFITAELFVVLIRRFASSRMVKKAIEVFDEMPKYGCPQDEAVFGALLDALCKNGDVKEAALVFEEMKVRFKPNLKIFTSLLYGWCKEGKILEAKHVLIQMKEAGFEPDIVVYNNLLSGYVLGNKMGDAFDLLKEMRSKGIDPNACSYTIVIQGLCKADRMVEAMRVFDEMEKNGCQGDVLAYTTLISGFCKWGKLERAYELLDRMKTEGLVPNSLTYLHIMVAHEKKEELEKCLELIEEMRKIGCVPDAGIYNVVIRLACKLEEVKEAARVWDEMERSGFSPGVDSFIVMIHGFIAQGCLVEACELFKEMVGRGLFCVPQYGVLKDLLNSLLRAEKLEMAKDLWSCIVSKGCELNVSAWTIWIHALFSEGLVKEACSYCMEMMDADLMPQPDTFAKLMKGLRKLYNRQIAAEITEKVRKMAADREITFKMYKRRGERDLKEKIKEKTDGRKRRARRRRWGPARSRSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGC0</accession>
    <name>A0A0D2QGC0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G062400</name>
        <name evidence="3" type="ORF">Gorai_024225</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGC0"/>
    <dbReference type="STRING" id="29730.A0A0D2QGC0"/>
    <dbReference type="Gramene" id="KJB18599">
        <property type="protein sequence ID" value="KJB18599"/>
        <property type="gene ID" value="B456_003G062400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788026"/>
    <dbReference type="eggNOG" id="ENOG502S2IV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSNHRYA"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34776:SF1">
        <property type="entry name" value="F17F16.3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0582073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="316" mass="35569" checksum="C787BFC9250B5681" modified="2015-04-29" version="1">MGQGQEHKTRDDPQLEIQERGEIFFFYRPKVNKEEVHSVDDVQRLYIVLRPESGERGVEEKQDPHSGKEGAKSRSSDQPQTGSSMNKTEGGQGSQEVNIEEEPLLRFIVMGRKRLPDPGKKSQTFWGFVELVTTKVEDVKDALKGEEYDTSSRGYRYQPPARAVGEGVYRIVRHNSSKNKMHTHLIYKLEFPPPKEENEPQESLNIEPEGSFLIQIKNPSQASNSQFRGVGNKRKAAFPAHLQGQLGKTRYHPADPPDFLNYEGCEFLLISASDDIDKELGLELGTEGEADPSCSDLVRTFGDTASTTPLFKGIWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QH60</accession>
    <name>A0A0D2QH60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
            <ecNumber evidence="4 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_006G260900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
            <location evidence="12">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 12"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QH60"/>
    <dbReference type="STRING" id="29730.A0A0D2QH60"/>
    <dbReference type="Gramene" id="KJB38563">
        <property type="protein sequence ID" value="KJB38563"/>
        <property type="gene ID" value="B456_006G260900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAGANKH"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="12" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112709" description="Pectinesterase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="13">
        <location>
            <begin position="39"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB38563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="561" mass="61090" checksum="8277659458A8CB59" modified="2015-04-29" version="1">MANNAIIGICAVFLVALVVAVVVGVTHIKNKNDGEEISSSNKAVQALCQPTNYKETCQKSLASSNSSDVKELIRTGFQAGLVEIKNVLAHSVTVQELIKDENNKAALGVCQEVLDLAIDDFQKSFDMLGEYDMSKIGKYLLELKTWLSGAFTSQQTCIDSFAESSNESSQKMQSILKTSMEITSNALAMLNGLSTIVKELNIPNIGNIDTTGVNRKLLSAEDMPEWISQADRKLLQAKPMDLKPNVVVAKDGSGKYDTINKALAEVPVKSPDRFVIHIKAGTYKEQINLTKKMTNVVFIGDGPTKTIITNDISVVKNPPVRTYRTATVAADGAGFMAKDIGFDNSAGPEGHQAVAFRATADRVIMFNCHFTGCQDTLYAHRERQLYSNCLITGTVDFIFGDAASIFQNCMLVVRKPGPGQNCMVTAQGRNDLGTNSAIVLQNCTISGAPDYIPVKDTNKAYLGRPWKQFARSIIMQSRIDDIIQPEGYAPMTGTIGIDTSFIAEFGNRGPGADTSRRVAWKGIKKIDINEANKWTPRVFLESETWIPSSGVPYSPDMVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMS0</accession>
    <name>A0A0D2QMS0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 85A1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G090300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QMS0"/>
    <dbReference type="STRING" id="29730.A0A0D2QMS0"/>
    <dbReference type="Gramene" id="KJB08575">
        <property type="protein sequence ID" value="KJB08575"/>
        <property type="gene ID" value="B456_001G090300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIAQPFM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF169">
        <property type="entry name" value="CYTOCHROME P450 85A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266266" description="Cytochrome P450 85A1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="56848" checksum="AE553D9CE98C83F4" modified="2015-04-29" version="1">MALFMVVLVLLFILALSICTALLRWNELKFSKKGLPPGTMGWPIFGETTEFLKQGPNFMKNQRARYGSFFKSHILGCPTAVSMDPELNRYILMNEAKGLVPGYPQSMLDILGKCNIAAVHGSTHKQMRGALLALISPTMIKQQLLPKIDEFMRNFVSDWDNKIIDIQEKTKQMAFLSSLKQIATVESTSIAQEFMPEFFKLVLGTLSLPIDLPGTNYRRGLKVKYPSAFRFSLHSIVSSRLSCSFITLQARKIILTILKQLIEKRRGNQESHKDMLAYLMSKDDNNRYKLSDDEIIDQIITILYSGYETVSTTSMMAVKYLHDHPSILEELRKEHMAIREKKRPEDPIEWNDLKPMKFTRAVIFETSRLATIVNGVLRKTTEEMELNGFVVPKGWRIYVYTREINYDPFIYPDPLAFNPWRWMDKSLESQSNFLIFGGGTRQCPGKELGIAEISTFLHYFITRYRWEEIGGEKLMKFPRVEAPNGLHIRVSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QN26</accession>
    <name>A0A0D2QN26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G185900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB21169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QN26"/>
    <dbReference type="STRING" id="29730.A0A0D2QN26"/>
    <dbReference type="Gramene" id="KJB21169">
        <property type="protein sequence ID" value="KJB21169"/>
        <property type="gene ID" value="B456_003G185900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAKIEMW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF2">
        <property type="entry name" value="OS09G0309100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="78019" checksum="EA75D0E5A3FCBBBF" modified="2015-04-29" version="1">MEIVKSILDIPVQDPQAEFSSADLTWKKFGTVEHQDDVALIPYTRVNDFIIGECCNVECPKRFHIERGRKRSKGSVKEYKNDDYLEYKLYWCSFGPENYGEGGGILPSRKYRLNTRFKHPIRAARPQSMRGCTCHFVVKRLYTRPSLVLIIYNVKCHINKSGFVCHGPLDKDTIGPIQQQTMSMIYQGIPKENVLGKNIECIQQYCGSDATFDTLASEYVRKLGMIIKRSTHELDRDDQASIRMWVERNKKSIFFYQDTSKMDPFILGIQTEWQLQQMARFGRHNLVAADSTFGIKKLKYPLCTLLVFDSRHHALPVAWIITPSVVKSDMSKWKKALNTFCPILFSLWRLRSSWLRNVVKKCSNIEVQREIFKRLGKIVYGTWSSVNTSVALEECIQDFVDQTAFVDYFRSSWMAKIEMWLLTLKSFPLASQAASGAIEAYHVKLKTKLFDDSHLGALLRVDWLVHKLTTELYSTYWLNRYADESNSFQNVKEEYIASTSWHRALQIPDSAVTLDDKYNLFAKVASLKGSSITHIVWNPGSDFAFCDSAWSMQGNFCKHVIKVNMMCDNDKACEPSMSSRSFGEIPMDLWKKPMDDSILLDESVAWSHQMLDQIKQLVELNSSNDIGIVVNNMPLKWISKKGRKFVGIPASFPALPSTSKSNLQKKNRKWKRLSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNF2</accession>
    <name>A0A0D2QNF2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G104700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the CemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNF2"/>
    <dbReference type="STRING" id="29730.A0A0D2QNF2"/>
    <dbReference type="Gramene" id="KJB08800">
        <property type="protein sequence ID" value="KJB08800"/>
        <property type="gene ID" value="B456_001G104700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QV51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WISFSIN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004282">
        <property type="entry name" value="CemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33650:SF2">
        <property type="entry name" value="CHLOROPLAST ENVELOPE MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33650">
        <property type="entry name" value="CHLOROPLAST ENVELOPE MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03040">
        <property type="entry name" value="CemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1001">Plastid inner membrane</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="153" mass="18354" checksum="47FAF1A7970AC9AA" modified="2015-04-29" version="1">MPVSSDRVQLKIWNRPCPSPVFLPWWISLSFNKSLKSWITNWWDTRQSKIFLNDIQEKSILEQFIEVGEFFLLDEMIKEYSKTHLQKLRIGIQKETIQLIKLYNEDHIHTILHFSTNLICFIILSGYSILENKHLLILNSWVQEFLYNLIDTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNL8</accession>
    <name>A0A0D2QNL8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G264100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNL8"/>
    <dbReference type="SMR" id="A0A0D2QNL8"/>
    <dbReference type="STRING" id="29730.A0A0D2QNL8"/>
    <dbReference type="Gramene" id="KJB59617">
        <property type="protein sequence ID" value="KJB59617"/>
        <property type="gene ID" value="B456_009G264100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769944"/>
    <dbReference type="eggNOG" id="KOG0557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAMAQNM"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000018">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.320.10:FF:000019">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF75">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT 5 OF PYRUVATE DEHYDROGENASE COMPLEX, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="182"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB59617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="462" mass="48346" checksum="CB1267B564E00239" modified="2015-04-29" version="1">MANVLQTSFLPSTSSLRRPSISGSKGKSQSLQVKAKIREIFMPALSSTMTEGKIVSWMKSEGDKLSKGESVVVVESDKADMDVESFHEGFLAAIMVEEGGVAPVGSAIALLAETEDEISEAKAKSQSSSSSTPQVVEEKPKQIEEAAPDVPAAAAAPSVPVAKAVTLGSAVHPASEGGKRIVASPYAKKLAKELKVDLGTVVGSGPLGRIVAKDVEAAAVAVPVAASPAKPDPVAPGIELGTVVPFTTMQGAVSRNMVESLSVPTFRVGYTITTNALDALYKKIKSKGVTMTALLAKATALALVQHPVVNSCCRDGNSFTYNSSINIAVAVAIDGGLITPVLQDADKVDIYTLSRKWKELVDKARAKQLQPHEYNTGTFTLSNLGMFGVDRFDAILPPGTGAIMAVGASQPTVVASKDGRIGMKNQMQVNVTADHRVIYGADLAAFLQTLAKIVEDPKDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QP37</accession>
    <name>A0A0D2QP37_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_003G064800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18681">
        <property type="protein sequence ID" value="KJB18681"/>
        <property type="gene ID" value="B456_003G064800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788059"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMNGIYM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000157">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000179">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013581">
        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="609"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1186"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1264"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1302"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1330"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="164"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="843"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="811"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB18681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1443" mass="162755" checksum="ECC5948964FB1D18" modified="2015-04-29" version="1">MAQLVGSDEIESLRFELAQIGRSIRSSFRSRTSSFRDGDHSEYELQWAEVQRLPTFERINTALFDDEEENGTSGSGNYVKGKRVVNVTKLGADERHMFIEKLIKQIEHDNLGLLKKLRHRIDKVGVKLPTVEVRYKNLHVEAQCELVRGKPLPTLWNTTKSLLSGLTNLPGSKQEAKISILNDVSGIIKPGRMTLLLGPPGCGKSTLLLALSGKLSHSLKVAGEITYNGYRLEEFVPQKTSAYISQYDLHTPEMTVREILDFSARFQGIGSRAEIMKEVSRREKQPGIVPDPDIDAYMKAISVKGQESTLQTDYILKILGLDICADTKVGDAIRRGISGGQKKRLTTGEMIVGPAKALFMDEISNGLDSSTAFQIVSCLQHLVHITDATALISLLQPAPEIFDLFDDVILLAEGKIVYQGPRTNICKFFEECGFKCPERKGIADFLQEVISRKDQEQYWYHKQQPYSYVSVDHFIKKFKEHHIGQNLDEELSKPFDKSQSHKDALSFKPYSLSKWELFKACSMRELLLMKRNSFTYVFKSVQLVIIASITMTTFLRTRMVVDVIHSSYFMGSLFYALVILHVDGFPELSMTVSRIAVFYKQRELCFYPAWAYAIPAAILKVPLSLLESFVWTSMTYYVIGYSPEVGRFFRQFLIYFGVHLTSISMFRCIASLFQTIVASTTVGALAIMIVLLFGGFILPRPSLPSWLEWGFWLSPLTYGEIGLSFNEFLAPRWEKVMSGNTSIGQQTLESRGLSFDGYFYWISVAALFGFILLFNAVFTLALTFLNPPGKSRTMISFERYSQLQRKDDKEGLHEESKHAVNDPGTVAGPKTGQTVLPFEPLTVTFQDVQYYVNIPQEMKERGYKHKKLQLLSGITGAFRPGVLTALMGVSGAGKTTLMDVLSGRKTSGIIEGDIRIGGYPKVQDTFARVSSYCEQNDIHSPLITVEESVVYSAWLRLPSQIDSKTKDEFVNKVIETIELDRVRDCLVGIPGVNGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRAVKNVVEMGRTVVCTIHQPSIDIFEAFDELILMKTGGHVIYCGPLGQNSMRVVEYFQNIPGVPKIKDNYNPATWMLEVTSTSVEVGNGIDFAQIFKGSTLCKENKELVKQLSSPTPGSKDLYFPTRFPQNGLEQFKACLWKQCLSYWRSPAYNLTRIVFMTASSLMFGVLFWQQGKNINNQQDLFSIAGSMYAVIIFFGINNCSTVLPLVSTERTVLYRERFAGMYSSWAYSFAQVLVEIPYLLTLAITYVIITYPMIGYEWSAYKLFWALYSMFCTLLYFNYLGMLLVSLTPNIQVASIVASSAYTMLNLFAGFIIPKPQIPKWWIWLYYICPTSWAMNGMLTSQYGDVDKQILAFGETKTVAAFIEDYFGFHHSSLGIVAIFLFIFPVICATLFAYFIGTLNFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSC8</accession>
    <name>A0A0D2QSC8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G184900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 5">Golgi apparatus membrane</location>
            <topology evidence="1 5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSC8"/>
    <dbReference type="STRING" id="29730.A0A0D2QSC8"/>
    <dbReference type="Gramene" id="KJB10120">
        <property type="protein sequence ID" value="KJB10120"/>
        <property type="gene ID" value="B456_001G184900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798897"/>
    <dbReference type="eggNOG" id="ENOG502RXRG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQSVYIV"/>
    <dbReference type="OrthoDB" id="10249988at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000017">
        <property type="entry name" value="SNARE-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF1">
        <property type="entry name" value="TSET COMPLEX MEMBER TSTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB10120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="109" mass="12486" checksum="641C379DD9CEBF48" modified="2015-04-29" version="1">MILAVLFANSEGNILVEQSVYIVYTVLGDVNVYVVGKDGYDELALAEVIFVITSAVKDVCGKLPTERLFLDKYRRICLTLDEIIWKGYLENTDKDRIRRLVRLKPPTEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSJ1</accession>
    <name>A0A0D2QSJ1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G126100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSJ1"/>
    <dbReference type="STRING" id="29730.A0A0D2QSJ1"/>
    <dbReference type="Gramene" id="KJB19961">
        <property type="protein sequence ID" value="KJB19961"/>
        <property type="gene ID" value="B456_003G126100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB19961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7286" checksum="8FD0494D8E073E24" modified="2015-04-29" version="1" fragment="single">WGDKDPWESIELERAYGDFDTVEDFVVLPNVGHCPQNEAPHLVNPLVESFVSHHSRSPANASKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVB6</accession>
    <name>A0A0D2QVB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein ENHANCED DISEASE RESISTANCE 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G241100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVB6"/>
    <dbReference type="STRING" id="29730.A0A0D2QVB6"/>
    <dbReference type="Gramene" id="KJB11110">
        <property type="protein sequence ID" value="KJB11110"/>
        <property type="gene ID" value="B456_001G241100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB11111">
        <property type="protein sequence ID" value="KJB11111"/>
        <property type="gene ID" value="B456_001G241100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766481"/>
    <dbReference type="eggNOG" id="ENOG502QQV7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIWSENG"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009769">
        <property type="entry name" value="EDR2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558">
        <property type="entry name" value="CW14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31558:SF16">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (DUF1336)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07059">
        <property type="entry name" value="EDR2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein ENHANCED DISEASE RESISTANCE 2 C-terminal" evidence="2">
        <location>
            <begin position="297"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="553" mass="62911" checksum="657EAD3FA7FB8C9C" modified="2015-04-29" version="1">MGSCVSTSDKRITTQKRNRPWSKKCRGKLSGSVSDGSKKRKSNGCVTDIAVSEYVRMDFEKGATTTCRRSEVSNSTFHLTQLQWHLSQMDAKVSCHEDTWFDSVSIMESESDEEFISVFGDGFPTMGTAIGNISSAQVLQYGASSCFVEGKCKYEQYHESYLKIDGGRLSKEETRESNARFSTMSSHGHELSRFGKEADDWKKKKLLDCSHGSFKSVKDERRSGFCKMLPSINFNEKILATNMASQSQRRKSAVYRLSVKRTSCDAEEYSSKQFLYRPRAGYAIPCSKDEKANRDCWSQIPSSKFQLRGETYFKDKRKCPASDFSPYTPIGVDLFICPRKINHIAQHVELPYFKPNGKIPPLLIVNIQLPTYPAAMFLGDGDGEGMSLVLYFKVSEDFDNNISPQCLETIKKFVDDEVEKVKGFTKDSNVLFRERLKIMAGLVNPDDLNLNSTEKKLVNAYNEKPVLSRPQHNFFKGSNYFEIDLDIHRFSFISRKGLESFRDRLKNGILDLGLTIQAQKQEELPEQVLCCLRLNKMDFSDNGQIPTLMTMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVN1</accession>
    <name>A0A0D2QVN1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_004G109700</name>
        <name evidence="16" type="ORF">Gorai_014542</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the MICU1 family. MICU1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVN1"/>
    <dbReference type="STRING" id="29730.A0A0D2QVN1"/>
    <dbReference type="Gramene" id="KJB23684">
        <property type="protein sequence ID" value="KJB23684"/>
        <property type="gene ID" value="B456_004G109700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791055"/>
    <dbReference type="eggNOG" id="KOG2643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRTEVWK"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15900">
        <property type="entry name" value="EFh_MICU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039800">
        <property type="entry name" value="MICU1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294:SF1">
        <property type="entry name" value="CALCIUM UPTAKE PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12294">
        <property type="entry name" value="EF HAND DOMAIN FAMILY A1,A2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="14">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB23684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0583695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="490" mass="55079" checksum="0FA64D4BAC538406" modified="2015-04-29" version="1">MFSLPSLRKSSPLIKQVVANQRSNSVRPVFNQSKDSSSSFLSLLKKPSSAGGSTAAGDKNSGGDQLLRSVSTGVLIAGSTLGFCYFSRSSFDSNYWVSFADAPNGATWAPDSVADQFEHGIPDKKSKYLFGESYRRRVFFNYEKRIRLQSPPEKVFDYFASYRTPEGDVLMTPGDLMRALVPVFPPSGSNRVREGSLRGEWVKPGELHCPPSKFFMLFDTNNDGLISFPEYIFFVTLLSIPESSFSVAFKMFDLDHNGEIDREEFKKVMTLMRSQNKQAARHRDGLRLGLKVAEPVENGGLVEYFFGQDGKTCLKHDTFVQFLRDLHEEILKLEFSHYDYKVHGTISAKDFALSLVASADISDISKLLDRVDEIDKESHLKDVRITFEEFKSFAELRKKLQPFSLAIFSYGKVNGVLTKKDFQRAASKVCEVSLTDNVVDIIFHVFDTNRDGSLSSDEFVKVVQRRERDDSQPKAESKGLISCLLSCAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXS1</accession>
    <name>A0A0D2QXS1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G226200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXS1"/>
    <dbReference type="Gramene" id="KJB43958">
        <property type="protein sequence ID" value="KJB43958"/>
        <property type="gene ID" value="B456_007G226200"/>
    </dbReference>
    <dbReference type="OMA" id="SAGNMKH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33696:SF20">
        <property type="entry name" value="DUF688 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33696">
        <property type="entry name" value="T22J18.15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="196" mass="22268" checksum="1A1261A33B07A4D8" modified="2015-04-29" version="1">MCGLCDKFILQNHHFQCIKYKQNNKQMLHFNTDKMSYGRKYTLSWEDKPGVSKSEPKVNHYDQDCPIGLELYDLNQKNYVSDPSGSSSILVLEKKVPPPPPLSVQLKGSPSGKGGLKWWQEDPFLLAYKECTKSGGNMKHLSSEAKESTGSSKLSRKKKITFSCKKSCDVSNDNFVRLSNLPPLPKRRIRGLHEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZ31</accession>
    <name>A0A0D2QZ31_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_004G045000</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZ31"/>
    <dbReference type="Gramene" id="KJB22386">
        <property type="protein sequence ID" value="KJB22386"/>
        <property type="gene ID" value="B456_004G045000"/>
    </dbReference>
    <dbReference type="OMA" id="RATETHN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000007">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001019">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF814">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250701" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="133"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="260"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="371"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="582"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB22386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="747" mass="83833" checksum="3EB75523942FB636" modified="2015-04-29" version="1">MWVKFTALSSILSHLLLSISLVEAFIRCYDTGNFTINSTYGKNRDLILASLPPNVSAKGGFFTANVGQNAYKVYALGMCRGDSSRDDCYKCVNSTIHDLKANCPNQKEALSWEGQPCHVHYADRSFYGTLEELGNPEAGYNTGDIKSNLTEFDTIWESLMDTVVRNASNGSSTRKYATREADFTVFQKIYALMQCTPDLSHEDCDSCLRQSVSNYESCCHGKQGGYVTRPSCYFRWDLYPFYSITTPSPSPDIKGINLTYQSFRCYNDSGSFTTSSTYGKNLDHILDSLPHNVSENGGFYEAIGGQDSNKAYALGMCRGDLSKGDCYRCVSSSVNDLRVKCFHWKEAVSLAVLRPCIVHYANRTFFGNLEVEPTDAAHNNESIKSDVLTKFEMAWDGLVVSLRRNASNGSSKFYATEEAKFTESQTIYALMQCTPDLSQENCWTCLKRATETHNDCCRAKQGGFVQKPNCYFLWDLHPFYALGPDNTFTKDETKQNKPIWIPLGASLSATLGLALFSACGFFIWRRRNGQEDKGQEVQLLDLVMGSVPRGNSSENFDLQNIGRSQEFPSIQLNILQAATNNFCDENKLGQGGFGPVYKGTLADGKEIAVKRLSRTSGQGLLEFKNEVMLIAKLQHRNLVRLLGCCLEKNEKLLVYEFMPNKSLDMFLFDSSLPAQLVWQKRFNIIKGTARGIMYLHEDSRLRIIHRDLKASNVLLDHEMNPKISDFGMAKIFGRDQNEANTNRVVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R033</accession>
    <name>A0A0D2R033_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_002G034900</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="18"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R033"/>
    <dbReference type="Gramene" id="KJB12755">
        <property type="protein sequence ID" value="KJB12755"/>
        <property type="gene ID" value="B456_002G034900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYEMEGR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000001">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000145">
        <property type="entry name" value="receptor-like serine/threonine-protein kinase SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1113">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE SD1-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250722" description="Receptor-like serine/threonine-protein kinase" evidence="20">
        <location>
            <begin position="23"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="22">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="23">
        <location>
            <begin position="339"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="511"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="820" mass="91987" checksum="E23356FDF9D707BC" modified="2015-04-29" version="1">MRLPKAEDPALISCFYLLFATALDTITPSKSIKDPDVIISQNGVFRLGFFSLANSSNRYVGILYNQIPVQTVVWVANRNRPLKDSSGILTISDDGNLVVSNGKAEVLWSSHVNNTAPNATTAQLLDSGNLVLSNGEDGASSLWESFEDPSNAFIETMKISTDVKTGRKVELKSWKSIDDPSDGNFSLSLEPFNSPEVIIRKNNQLYHRTGPWNGNSFIGLIDEYTAYLEGFDVVADNPQQAYYMTYDFSNDSMLIYIELDSQGKFIERKWDEGKGNWINKYSSYQTNCDVYGYCGAFGICDSSKRPICSCLKGFKPRNIEEWSRGNWSSGCFRTTPLQCKRDNNNGSGAGQGDDGFLEMKMMKVPAFPHPSSISNGQCKDQCMNMKNCSCVAYAHDDGIGCMLWSGDLIDVQKFSASGVDLYIRLPSSELDKGKSSKVIVITTVTAGIVAITISALFLWCGMAKQRGTNKRHKQIKHKSYSENVGESLIGVKLQQLPLFNFEELATATNNFHPEKKLGQGGFGPVYKGTLDDGKEIAVKRLSKASGQGLEEFMNEVVVMSKLQHRNLVRLFGCCVEAEEKILVYEFMPNKSLDAFLFDPVKRRLLDWRKRFNIIEGISRGLLYLHRDSRLRIIHRDLKASNVLLDQDLNPKISDFGMARIFGGGENQANTKRVVGTYCNWCCFSEKSDVFSYGVLLLEIVSGRRNTSFYNKDDLSLLGYAWRLWREGNIWRLVDEVIFESESDSNNEKEIWRCIHVGLLCVQEYTKDRPTISTVISMLNSEISDLNTPKQPAFTQAPLMSHNVKDRGSLNDVTLTNLDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1J4</accession>
    <name>A0A0D2R1J4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">soluble epoxide hydrolase</fullName>
            <ecNumber evidence="2">3.3.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G091300</name>
        <name evidence="10" type="ORF">Gorai_014415</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Epoxide hydrolase involved in the biosynthesis of cucurbitacin and mogroside tetracyclic triterpene natural products (e.g. siamenoside I and mogrosides IV, V and VI). Cucurbitacins have cytotoxic properties and exhibit deterrent taste as a defense barrier against herbivores. Mogrosides are nonsugar highly oxygenated compounds used as high-intensity zero-calorie sweeteners; they also possess pharmacological properties such as regulating immunity, lowering blood sugar and lipid levels, protecting the liver, and acting as antioxidants and antitumor agents. Catalyzes the hydrolysis of aromatic epoxide-containing substrates, such as the conversion of 24,25-epoxycucurbitadienol to 24,25-dihydroxycucurbitadienol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(24S)-24,25-epoxycucurbitadienol + H2O = (24R)-24,25-dihydroxycucurbitadienol</text>
            <dbReference type="Rhea" id="RHEA:81855"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:229949"/>
            <dbReference type="ChEBI" id="CHEBI:229950"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:81856"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19038"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1J4"/>
    <dbReference type="STRING" id="29730.A0A0D2R1J4"/>
    <dbReference type="Gramene" id="KJB23306">
        <property type="protein sequence ID" value="KJB23306"/>
        <property type="gene ID" value="B456_004G091300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790838"/>
    <dbReference type="eggNOG" id="KOG4178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSINWYR"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000161">
        <property type="entry name" value="Epoxide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="8">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00051067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB23306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0583564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="316" mass="35824" checksum="CDE6C0839925C697" modified="2015-04-29" version="1">MEKIEHTTVTTNGIKMHVASIGSGPIILFLHGFPELWYTWRHQLLSLSSLGYRCVAPDLRGYGDSDAPPSPESYTVFHIVGDLVGLLDALGVDKVFLVGHDWGAMIAWNFCLFRPDRIKALVNLSIPYHPRNPKVKTVDGYRALFGDDFYICRFQVPGEAEAHFAQMDTAKVMKKFLTTRDPNPPCIPRETGLKALPDPPALPSWLSEDEINYFATKFSQKGFTGGLNYYRAMNLNWELMAPWTGLQIQVPVKFIVGDLDITYHIPGVKEYLQNGGFKKNVPFLQELVVMEGVAHFINQEKPQEISMHIYDFIKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1T5</accession>
    <name>A0A0D2R1T5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tubby C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G095500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1T5"/>
    <dbReference type="STRING" id="29730.A0A0D2R1T5"/>
    <dbReference type="Gramene" id="KJB23391">
        <property type="protein sequence ID" value="KJB23391"/>
        <property type="gene ID" value="B456_004G095500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790888"/>
    <dbReference type="eggNOG" id="ENOG502QUU9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PICTLRP"/>
    <dbReference type="OrthoDB" id="97518at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.200">
        <property type="entry name" value="LURP1-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007612">
        <property type="entry name" value="LOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038595">
        <property type="entry name" value="LOR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31087:SF160">
        <property type="entry name" value="PROTEIN LURP-ONE-RELATED 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04525">
        <property type="entry name" value="LOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24135" checksum="55B298135DCFD39F" modified="2015-04-29" version="1">MEHVQAYPPPAAPSAYPPLATPVPVIGPQYCYPQPVDLAVVRKVLTITEGNFAVTDINGNIMFKIKGKFFSIHDRRLLTDAAGNPVCTLRPKIMTVHDRWQVFRGESTEEKDLIFTVKRSSMIQLKTKLHVFLATNPKEDVCDFRVEGSWLERSCIIYSGESNTILAQMHKKHSVESILLGKDKFMVTVYPNVDYAFVVALIAILDGINQDDDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R380</accession>
    <name>A0A0D2R380_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rapid alkalinization factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G239600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant rapid alkalinization factor (RALF) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R380"/>
    <dbReference type="Gramene" id="KJB26394">
        <property type="protein sequence ID" value="KJB26394"/>
        <property type="gene ID" value="B456_004G239600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792505"/>
    <dbReference type="eggNOG" id="ENOG502S1TF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDHHYHN"/>
    <dbReference type="OrthoDB" id="1613518at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008801">
        <property type="entry name" value="RALF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136:SF107">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05498">
        <property type="entry name" value="RALF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249913" description="Rapid alkalinization factor 1" evidence="7">
        <location>
            <begin position="28"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB26394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="13612" checksum="CEF66F6B024F1F7B" modified="2015-04-29" version="1">MAVLNSCKLVWICAVIVAAALMVAVDASGDHHYHNQKILGWIPTPTRSSCNGSIGECLGGEEEFELDSEISRRVLQTTRYISYGALQRNTVPCSRRGASYYNCQPGAQANPYNRGCSRITRCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R508</accession>
    <name>A0A0D2R508_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G365900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB46403">
        <property type="protein sequence ID" value="KJB46403"/>
        <property type="gene ID" value="B456_007G365900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEKWENW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Apaf_helical"/>
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    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
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        <property type="entry name" value="Rx_N"/>
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    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="188"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="431"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="567"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="7">
        <location>
            <begin position="925"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="7">
        <location>
            <begin position="1072"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB46403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1286" mass="147457" checksum="D1283821D07BF373" modified="2015-04-29" version="1">MAEAIAFDLALELITKLSSRALSQVGMWWNLKHDLDDLKRTVRTIKAVLLDAEEKSVTDNLVKVWLEELKDVLYDADDLLDDFSTEALRKDLMGGNKLTKEVRLFFSSSNQFAYGLKMGRKIKTIKARLFSIASEAKVFNLVERHRPMETSFMTKKRQQTHSFVPKDKIIGRDDDKAALLKLVLEFESEETVYIIPIVGFGGLGKTALAQFVYNDEMVKNHFELMMWVCVSDVFDVKIIVENMIKSATGQAPDQNLEMDQLQKQLREKIGGKKYLLVLDDIWNEKWENWVSLKELLVGGAKGSRIIVTTRSLGVAKITSKCQPYVLKGLSDNDAWSLFKEIAFEQRSADSTDSGFVEIGKLILERCCGVPLVIRTIAGTLSFKETKSEWLSFKDKELARISQNEGEILPTLKLSYDHLSSHLKHCFAYCRLYPKDHEIDVRTLVQFWIAQGFVKQLNPSQSLEEIGFGYFKDLVERSFFQEVEEYGIGDMRCKMHDLMHDLAESVAGMESSIVDSNNIASDGGEKCRHISINPSLIPLFKGKKLRTLLRYPNKFSAHLSEETWEFVITNCRCLRVLDFRWLGIQMISPSIYKLKHLRYLDLSANYNIKILPESICKIQNLLALKLDSCHRLKELPKKIEKLVNLTHLACYFCDRLTHMPRGIGKLTSLETLSMFVVDKDGSHGGADLSELRLLNNLRGRLTITNLGFVKNAKEKFKAANLNEKQHLRWLGLEWGGGNHDDEKSLEDLQPHPNLKQLCIGGWRGDAKFPSWISFLTNLVKIFISGGNFKYFPSFAQLPRLELLDISFCTKLEYIDDNSLKGSQGEPQSFFPSLKHLRLSQCLHMKSWWRMTKPINDDSNQDDTTVMGTSTMAFPCLSSLWIQNCPLTLMPLYPSLDEDLILLNTSSRPLKQTIKMNINAKAPSTSTSSLPLSKLKSFHVHTIEGLDTHTLYECLQHLTSLKSLTIRDCKEVDLEGMQWEPLKNLSHLEIDNIPKLVSLPIGLQHLLQLKTLKIHNCNGLRSLLPVFQHLTFLEEFEVKDCKEVDLEGMQWEPLKNLSHLEIDNIPTLVSLPIGLQHLLQLKTLKIHNCNGLRSLLPVFQHLTFLEEFEVKDCKEVDLEGMQWEPLKNLSHLKIDNIPKLVSLPIGLQHLVQLKRLKIHNCNGLRSLFPVFQHLTFLEEFEVEDCKELELSGAGIQIFQDHTSLHSLRLQNIPKCRHLPDWLQHLTNLQRLYLVNLPNLTSLLDEMRCLTSLEYLHIREIPQLEERCRKDIGADWQKIAHVPNIVLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R659</accession>
    <name>A0A0D2R659_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G167900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R659"/>
    <dbReference type="Gramene" id="KJB24921">
        <property type="protein sequence ID" value="KJB24921"/>
        <property type="gene ID" value="B456_004G167900"/>
    </dbReference>
    <dbReference type="OMA" id="SIIECFE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB24921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="112" mass="13107" checksum="7FB9C92501D307C8" modified="2015-04-29" version="1">MPPHTSRKCLAPKHARGESSSAPLDHPSIIECFEDSDFFEKFNTYFATCTVQISRLADLNFLANTLKFKYLDQLRYWGWLECLQLRGPCYDNLVRAFYSNAKLNFQSFSIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R732</accession>
    <name>A0A0D2R732_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_005G005600</name>
        <name evidence="18" type="ORF">Gorai_015858</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R732"/>
    <dbReference type="STRING" id="29730.A0A0D2R732"/>
    <dbReference type="Gramene" id="KJB27704">
        <property type="protein sequence ID" value="KJB27704"/>
        <property type="gene ID" value="B456_005G005600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796298"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KMEGCQE"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000653">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF28">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="12"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="16">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="420"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB27704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0585067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="450" mass="50900" checksum="622F7F4C1C007B78" modified="2015-04-29" version="1">MEPKGVVLMGRYEIGRLLGQGTFAKVHRARNLETGMNVAIKIVDKEKVLKVGMIDQIKREISVMRLVRHPNVIELYEVMATKTKIYFVMEYAKGGELFNKVVKGKLKEDAARKYFQQLISAVDFCHSRGVCHRDLKPENLLLDENCNLKVTDFGLSALAESKQQDGLLHTTCGTPAYVAPEVINRRGYDGCKADIWSCGVILYVLLAGYLPFQDSNLMEMYRKIGKGEFKFPNWFAPDVRRLVSKILDPNPKTRISMEKIMENPWFRKGLDPKPELVDPEVKEPAIGLQTGTPCNLNAFDIISLSAGFDLSGLFREQEQKKEVRFTSNKTASTIISKLEDVAKRLRLKIKKKGGGLMKMEGCQEGRKGVLGIDAEIFEITPFFHLVEVKKSNGDTLEYQKVMQQDIRPALSDIVWAWQGEPLPQQLPPPPPTEEQHHESHPFHVVSTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RC19</accession>
    <name>A0A0D2RC19_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="10">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_010G221800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="10"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RC19"/>
    <dbReference type="STRING" id="29730.A0A0D2RC19"/>
    <dbReference type="Gramene" id="KJB68007">
        <property type="protein sequence ID" value="KJB68007"/>
        <property type="gene ID" value="B456_010G221800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHDMYER"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010227">
        <property type="term" value="P:floral organ abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010229">
        <property type="term" value="P:inflorescence development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000350">
        <property type="entry name" value="Mitogen-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000388">
        <property type="entry name" value="Mitogen-activated protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF762">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0381">Hypersensitive response</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="72"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB68007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="349" mass="38875" checksum="4FFBAB0A05F39335" modified="2015-04-29" version="1">MRPNQHSQPPAVGGSSSANRNRPRRLAELTVPLPQRTVSLPVPLPLPPASSAAQSTCSNGNANSKQVNLSEIDRVNRIGSGAGGTVYKVIHRPSSRLYALKVIYGNHEETVRRQIRREIEILRDVNHPNVVKCHEMYDQNGEIQVLLEFMDVGSLEGTHISHESNLSDLARQILNGLNYLHRRHIVHRDIKPSNLLINSKKKVKIADFGVSRILDQTMHPCNSSVGTIAYMSPERINTDLNQGQYDGYAGDIWSLGVSILEFYLGRFPFAVGRQGDWASLMCAICLSQPPEAPPTASYEFRHFISCCLQKDPTRRLTAAQLLQHPFIIRGQNQVAQNLHQLLPPPPLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RE72</accession>
    <name>A0A0D2RE72_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G130900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RE72"/>
    <dbReference type="STRING" id="29730.A0A0D2RE72"/>
    <dbReference type="Gramene" id="KJB30129">
        <property type="protein sequence ID" value="KJB30129"/>
        <property type="gene ID" value="B456_005G130900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794063"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRTAPGM"/>
    <dbReference type="OrthoDB" id="962189at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13a-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF39">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB30129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23616" checksum="1632EDCD5275F06E" modified="2015-04-29" version="1">MVSGSGICAKRVVVDARHHMLGRLASILAKELLNGQKVVVVRCEEISMSGGLVRQKMKYMRFLRKRMNTKPSHGPIHFRAPAKILWRTIRGMIPHKTKRGAAALARLKAYEGIPAPYDKIKRMVIPDALKVLRLQKGHKYCLLGKLSSEVGWNHYDTIKELERKRKERAQVAYERRKQLTKLRVKAEKVAEEKLGTQLEVISPIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RL20</accession>
    <name>A0A0D2RL20_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G136200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RL20"/>
    <dbReference type="SMR" id="A0A0D2RL20"/>
    <dbReference type="STRING" id="29730.A0A0D2RL20"/>
    <dbReference type="Gramene" id="KJB30296">
        <property type="protein sequence ID" value="KJB30296"/>
        <property type="gene ID" value="B456_005G136200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794133"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDIFTRW"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010182">
        <property type="term" value="P:sugar mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000281">
        <property type="entry name" value="E3 ubiquitin-protein ligase SIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044793">
        <property type="entry name" value="SIS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47179">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47179:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB30296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="42561" checksum="68D56648F9620546" modified="2015-04-29" version="1">MAIRGVDFKWYDGFFLSMLATSVIIVAINWKRYHHCTYPLHIWIVVDYSTVFIFRLLMFVDNGLAAGMGLDFGWQQRYARFCGRIVVLSILSMLLYPFLWAWTVIGTLWFTSARNCLPKEGQKYGFLIWLLFSYCGLLCIACMSVGKWMTRRQAHLLRAQQGIPISEYGVLVDMIRVPDWAFEAAGQEMRGMGQDTAPYHPGLYLTPAQREAVEALIQELPKFRLKAVPTDCSECPICLEEFHVGNEVRGLPCAHNFHVECIDQWLRLNVKCPRCRCSVFPNLDLSALSNLRSADSERSSASIVTTTQYVRTQPLSQSYLLRLQGLLRPVRTGNAGAPSDADVALDTAENGAFNVATQDSTGREAVGHALGGLSTPPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RL97</accession>
    <name>A0A0D2RL97_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G139700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RL97"/>
    <dbReference type="Gramene" id="KJB30371">
        <property type="protein sequence ID" value="KJB30371"/>
        <property type="gene ID" value="B456_005G139700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794178"/>
    <dbReference type="eggNOG" id="KOG0637">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQAFAMF"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17313">
        <property type="entry name" value="MFS_SLC45_SUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000366">
        <property type="entry name" value="Sucrose transport protein SUT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000182">
        <property type="entry name" value="Sucrose transporter SUC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="8" id="KW-0769">Symport</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="469"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="65751" checksum="95471DAE33046EF1" modified="2015-04-29" version="1">MAGMSDSVPIRFPYRNLNKELEVEMIDDPHFRIDLNSSPNSPSASSSSPASRVPNGNANLSSPIHAGSKDCSLITLVLSCTVAAGVQFGWALQLSLLTPYIQTLGIEHAFSSFIWLCGPITGLVVQPCVGIWSDKCTSKYGRRRPFILAGALMISLAVIIIGFSADIGYLLGDTKEHCSTFKGTRTRAAFVFVIGFWMLDLANNTVQGPARALLADLSGPDQHNSSNAIFCSWMAVGNILGFSAGASGSWHRWFPFLENRACCEACANLKAAFLVAVVFLLFCTVVTVCFAKEVPLPLPADQPTRLSDSAPLLDGSTQKGFQHSKSKADASIVPNDNRNIAENGYEWVSNSKLANSKDNNSQNEVFSDGPGAVLVNLLTSLRHLPPAMHSVLIVMALSWLSWFPFFLFDTDWMGREVYHGDPKGNASETKLYDQGVREGAFGLLLNSVVLGISSFFIEPMCQRIGSRLVWAMSNYTVFACMGVTAIISLVSVTEYSEGIEHVFGGGGAIKIAALVVFALLGFPLAITYSVPFSVTAELTADSGGGQGLAIGVLNLAIVIPQMIVSLGAGPWDALFGGGNIPAFILASFCALAAGIIATLRLPDLASSFKSSGFHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQK5</accession>
    <name>A0A0D2RQK5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G051200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQK5"/>
    <dbReference type="Gramene" id="KJB34164">
        <property type="protein sequence ID" value="KJB34164"/>
        <property type="gene ID" value="B456_006G051200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46667:SF6">
        <property type="entry name" value="OS01G0185100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46667">
        <property type="entry name" value="OS05G0182700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB34164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="153" mass="16571" checksum="9FAA140A9657FF3C" modified="2015-04-29" version="1">MINFFENTVMAMQTGVGLSKILILAGAGYTGTVLLKNGKLLDILGELQSLVKGLEKSGEQANDSDALLAQVRRLSTGMGILAEKYFFKHTRPKRPKSLRIYESHVGMSSPGLGPYSTSIKKVEKEIKEMAKKVNDLCGTEVSSFKCKMVAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RR20</accession>
    <name>A0A0D2RR20_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="7">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_011G219600</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="7"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RR20"/>
    <dbReference type="STRING" id="29730.A0A0D2RR20"/>
    <dbReference type="Gramene" id="KJB73162">
        <property type="protein sequence ID" value="KJB73162"/>
        <property type="gene ID" value="B456_011G219600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776856"/>
    <dbReference type="eggNOG" id="KOG2292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TKELWSP"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000002">
        <property type="entry name" value="dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="20">
        <location>
            <begin position="28"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="21">
        <location>
            <begin position="543"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB73162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="720" mass="81433" checksum="E75F752EE9F70D9A" modified="2015-04-29" version="1">MATMPASASDLLKSFKLKTKQQELLIRVSILCLVYILAFITRLFSVLRYESMIHEFDPYFNYRTTLYLTENGFYDFWNWFDYESWYPLGRIVGGTLYPGLMVTAVLIYRILRFLRFAVHIREVCVLTAPFFASNTTLVAYFFGKEIWDSGAGLVAAILIAVCPGYISRSVAGSYDNEGVAIFALLFTFYVFVKAVNTGSLAWSLASAFGYFYMVSAWGGYVFIINLIPLYVLVLLITGRYSMRLYVAYNCMYILGMLLAMQIRFVGFQHVQSGEHMAAMGVFFLMQVFYFLDWVKHMLSDTKLFQAFLRITVTSAVAVGGIALGLGMVSGYISPWTGRFYSLLDPTYAKDHIPIIASVSEHQPTAWSSFMFDFHILLFLFPAGLYFCFKRLSDATIFIVMYGLTSMYFAGVMVRLILVATPAVCLISAIAVSATVKNLTVLLRSKNKVVQTGSTKGSGGSKSSSKALLDQSQPFQKNGAIALLFGAFYLLSRYATHCTWVTSEAYSSPSIVLAARGAHGNRVIFDDYREAYFWLRQNTPQDAKVMSWWDYGYQITAMGNRTVIVDNNTWNNTHIATVGRAMSSYEDEAIEIIRSLDVDYVLVVFGGVTGYSSDDINKFLWMVRIGGGVFPVIKEPDYLVNGEYRVDKGAAPKMLNCLMYKLCYYRFGEMMTEYGKPPGYDRARGVEIGNKDVKLEHLEEAFTTSNWIVRIYRVKPPNNRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RR31</accession>
    <name>A0A0D2RR31_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_005G217300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">May be involved in plant defense signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RR31"/>
    <dbReference type="STRING" id="29730.A0A0D2RR31"/>
    <dbReference type="Gramene" id="KJB31971">
        <property type="protein sequence ID" value="KJB31971"/>
        <property type="gene ID" value="B456_005G217300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="141"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="427"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="437"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="474" mass="53186" checksum="63CA24D3F903635C" modified="2015-04-29" version="1">MSPQKKGWWIKAEKKVEFFEHQLVKRYICFSFYGLEILCFAIADLCVWLCSNEVGKGKGKRFFKMGICWGSSADNPTPTTTGCLSSVISQTTSNTASTSISRGSRFSASSGDEVFPNGQILPAPDLRIFSFAELKSATKNFRPEMVLGEGGFGKVFKGWLDEKSPGKSGSGTLIAVKKLNSESLQGFEEWQSEVNFLGRFSHPNLVRLLGYCWEDQELLLVYEFMQKGSLENHLFGRGSTVQSLEWSIRLKIAIGAAKGLSFLHTSDKQVIYRDFKASNILLDGSYTAKISDFGLAKLGPSASKSHVTTRVMGTYGYAAPEYVATGHLYVKSDVYGFGVVLVEILTGLRALDQNRPSGQHTLVDWVKPHLSERRKLKNIMDHRLEGKYPSKAAFRIAQLALKCLEPEPRNRPSMKEVVETLEQIESINEKPTEPKNRSTHHTTRRRRQQPFHQRSPLAPKHEVGHGYQTPPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRQ2</accession>
    <name>A0A0D2RRQ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G070900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRQ2"/>
    <dbReference type="STRING" id="29730.A0A0D2RRQ2"/>
    <dbReference type="Gramene" id="KJB34534">
        <property type="protein sequence ID" value="KJB34534"/>
        <property type="gene ID" value="B456_006G070900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEKWGIN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF884">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE OXIDASE HOMOLOG 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="168"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB34534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="242" mass="27136" checksum="1035A2518AC1EBBF" modified="2015-04-29" version="1">MAEISLERAQESIVDRQQELKALDETKSGVKGLVDSGLHRRTKVGEACEKWGINHGIPLATTDEMINGLRRFHEQDDEAKKEIYSRDYSKKVYYNSNIDLYKAEATSWRDTLCCVMAPRHPLPQELPAVCRDIVIEYSSKMMKLGQTLLELISEALGLNRSYLEDIGCGEGMLVKCHYYPPCPEPDLTLGSSSHTDTGFCTVVLQDEIGGLQILYQNQWLDVNPVRGALVVNLADMMQASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSK6</accession>
    <name>A0A0D2RSK6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G029900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSK6"/>
    <dbReference type="STRING" id="29730.A0A0D2RSK6"/>
    <dbReference type="Gramene" id="KJB22110">
        <property type="protein sequence ID" value="KJB22110"/>
        <property type="gene ID" value="B456_004G029900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSN2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TPNFREG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040356">
        <property type="entry name" value="SPEAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33388">
        <property type="entry name" value="OS01G0212500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33388:SF1">
        <property type="entry name" value="PROTEIN SPEAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB22110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="427" mass="46763" checksum="4F9C3F596AD388EA" modified="2015-04-29" version="1">MAQEDQMTQRYSDSNSNSGSGIGIGSNNNGRYSKKQRPKKVPQRGLGVAQLEKIRIEEQQKKDAAILPFQSPVVNVNLHHHHHKPSASASISPSCFPLPIPTFLPSNQSCSSLASADISPPNSMFRPPNGDIVSTANTVPLTCNIGQNKTWGSCDYEYNNIEKECCGLDPGLAFRTNLSLPYESEPIWPLPCLMQRAQQQQPFQQPSSSLVNLSSRTSSTSILNFQIEPPSNQSYYGNCTPLFPEDDKVVGMKRSYPFSLDNAPGPPIYTKYPPIVHFINGQVEAASSSNGSTFNFEPGTPNFREGPSCSTSNMESKSKKSIKQNGVYDGDFLTLAPPTTTMCSSSKFKHPSSILTYYNCELPDLESLASFDDSIVRQGGASGFNQSYRPYYSFLPPALVQIDQATTISMANCKGGEVEHVDLDLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUN4</accession>
    <name>A0A0D2RUN4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein kinase BSK1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G2959001</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUN4"/>
    <dbReference type="STRING" id="29730.A0A0D2RUN4"/>
    <dbReference type="Gramene" id="KJB74447">
        <property type="protein sequence ID" value="KJB74447"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74448">
        <property type="protein sequence ID" value="KJB74448"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74450">
        <property type="protein sequence ID" value="KJB74450"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74451">
        <property type="protein sequence ID" value="KJB74451"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74452">
        <property type="protein sequence ID" value="KJB74452"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74453">
        <property type="protein sequence ID" value="KJB74453"/>
        <property type="gene ID" value="B456_011G2959001"/>
    </dbReference>
    <dbReference type="OMA" id="ACERPNA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000016">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045845">
        <property type="entry name" value="BSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863:SF8">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine/threonine-protein kinase BSK1-like TPR repeats" evidence="9">
        <location>
            <begin position="87"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB74452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="236" mass="26429" checksum="BEE6EDC25F89EE79" modified="2015-04-29" version="1" fragment="single">ALDLIREKNLLLLMDSSLEGQYANEDARELVELASKCLQYEARDRPDTKFLHSAVAPLQKQEVASHILMGLSKTPVVLPTMISPLGKACARMDLTAVHDILLKTGYKEEEGAENELSFQEWTQQVQDMLNTKKFGDIAFRDKDFKNAIDYYSKLVAMMSVPSGTVFVRRALSYLIIGQPELALRDAMQAQVCLPECPTAFYMQALALSKLGMETDAQDMLNDGASFEAKKQNGWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUS9</accession>
    <name>A0A0D2RUS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="MBA0586912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2RUS9"/>
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    <dbReference type="eggNOG" id="KOG0907">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="match status" value="6"/>
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        <location>
            <begin position="200"/>
            <end position="233"/>
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        <location>
            <begin position="576"/>
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            <begin position="87"/>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0586912.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_012G043400"/>
    </dbReference>
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002250563" description="Cathepsin propeptide inhibitor domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
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            <begin position="41"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB75477.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="98" mass="11547" checksum="DA3F63C20A0C1166" modified="2015-04-29" version="1">MASKNQLHHHFTCLALLIFILGVCEATSRAALEDASMYERHQQWMVQFGRVYKDTNERQKRFQIFKQNMARIDSFNAANNKPYKLGMNQFADLTNQEF</sequence>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYL2"/>
    <dbReference type="STRING" id="29730.A0A0D2RYL2"/>
    <dbReference type="Gramene" id="KJB24145">
        <property type="protein sequence ID" value="KJB24145"/>
        <property type="gene ID" value="B456_004G129800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR9B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HECSREA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053277">
        <property type="entry name" value="Endomembrane_traffic_mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45005">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45005:SF2">
        <property type="entry name" value="PROTEIN HLB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06552">
        <property type="entry name" value="TOM20_plant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB24145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59940" checksum="0E264239B4B1366C" modified="2015-04-29" version="1">MSETTEGSELQNGFQPQPRPEPEPESELKVESQPEQQPEEELKPEPVVTDADPKPEPNNESSIQSNETTKQASTDQVAPPGRRKDEENRTFTMRELLSELKSDEDDAGSPYSQENTQRQSYQNNAAMELINSVTGTDEEGRSRQRILVYAARRYATALERNPEDYDALYNWALVLQESADNVSPDSTSPSKDALLEEACKKYDEATRLCPTLHDAFYNWAIAISDRAKMRGRTKEAEELWEQKSLVFSKECLAVVIKALSFTLIEPNPIVMGFQATKNYEKAVQLNWNSPQALNNWGLALQELSAIVPAREKQKIVRTAISKFRAAIQLQFDFHRAIYNLGTVLYGLAEDTLRQGSPNLKEVSPDELYSQSAIYIAAAHALKPNYSVYSSALRLVRSMLPLPHLKDGYLTAPPVGNSMAPHGAWKRTEFFLNHEALQQVIRVDQRQITRSLSGRTSDVTDMDKRAIRVDIPDIVSVSACADLTLPPGAGLCIDTTSGPVFLVADSWESLDGWLDAIRLVYTIYARGKTDILAGIITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S491</accession>
    <name>A0A0D2S491_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_006G161000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S491"/>
    <dbReference type="SMR" id="A0A0D2S491"/>
    <dbReference type="STRING" id="29730.A0A0D2S491"/>
    <dbReference type="Gramene" id="KJB36476">
        <property type="protein sequence ID" value="KJB36476"/>
        <property type="gene ID" value="B456_006G161000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799735"/>
    <dbReference type="eggNOG" id="KOG0227">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2690:FF:000002">
        <property type="entry name" value="Splicing factor 3a subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="216"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="233"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB36476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="37693" checksum="FEABFFA7111CE7F4" modified="2015-04-29" version="1">MDRDWGSKPGSGGAASAQTEAMDRRERLRRLALETIDLAKDPYFMRNHLGSYECKLCLTLHNNEGNYLAHTQGKRHQTNLAKRAAREAKEAPAQPQPHKRKVSVRKTVKIGRPGYRVTKQYDPETKQRSLLFQIEYPEIEDNTKPRHRVMSSYEQRVQPFDRRYQYLLFAAEPYEIIAFKVPSTEIDKSTPKFFSHWDPDSKMFTLQVYFKTKPLEVNKPPPPPAVNGTAAPGAPPRPLPPPPHAPAPPPPPPPQGLPNPPRGPPPPAPGSLPPPPPPMGNGPRPMPPGGNPIAPPPPPGGSGTMGNFTPRPPTNPPPQGFPGHQMQGQGMHPPPPPPNMGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S632</accession>
    <name>A0A0D2S632_GOSRA</name>
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        <recommendedName>
            <fullName evidence="19">SET domain-containing protein</fullName>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
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    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
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    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <location evidence="1">Centromere</location>
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        <subcellularLocation>
            <location evidence="9">Nucleus</location>
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        <property type="protein sequence ID" value="KJB78527"/>
        <property type="gene ID" value="B456_013G003600"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="H3-K9-MeTrfase_plant"/>
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        <property type="entry name" value="H3K9_HMTase_SUVAR3-9"/>
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        <property type="entry name" value="PUA-like_sf"/>
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        <property type="entry name" value="SRA_YDG"/>
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    <dbReference type="PANTHER" id="PTHR45660">
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    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
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    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="205"/>
            <end position="352"/>
        </location>
    </feature>
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        <location>
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            <end position="488"/>
        </location>
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        <location>
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        </location>
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        <location>
            <begin position="651"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="10">
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="667" mass="74090" checksum="335F444F46473598" modified="2015-04-29" version="1">MEGGVAGNSVPPNSFDKSKVLDVKPLRSLLPVFPEAPNGPPFVCAPPNGPFPTGFSPFFPFSGPQGSPLTPGLNQNLFNSTAMPIRSFRAEPPPASNGENVQSSNKRKSVGPSSVKKKVKRSNDSELALAALTNFKPGISAAEKDDGNRELVENVLMRFEALRRKLSQMEDAKESHSDIFKRANLKAGNIMFTKGVRTNGKKRIGVVPGVEIGDIFFFRMELILIGLHSQSMAGIDFMPMKADIEGERVAISIVSSGGYEDNAEDPDVLVYTGQGGNASADKEASDQKLVRGNLALERSLHRANEVRVIRGFKDATHQTSKVYVYDGLYKVQESWMEKGKTGCNMFKYKLVRLPGQTGAFSTWKSIRKWKEDPSSRDGLILPDLTSGAESIPVSLVNEVDDEKGPAYFTYVSTVKYPKSFKLVQPSYGCNCRDACQAGNSNCSCIQKNGGDFPYITTGILACRMPMIFECGSSCPCFRNCKNRVLQTGFKVHFEVFKTRDKGWGLRSWDPIRAGTFICEYAGEVIEKIKEKADGDDGENNDYVFNTNRVYESFKWNHETESAEERSDTSEKFDIPSPLIISSKNSGNIARFMNHSCSPNVFWQPIMYENNNEAFLHIAFFAKKHIPPMTELTYDYGIPRSDETESNNMEHGKKKCLCGSPKCRGYFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S8D0</accession>
    <name>A0A0D2S8D0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G250300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S8D0"/>
    <dbReference type="STRING" id="29730.A0A0D2S8D0"/>
    <dbReference type="Gramene" id="KJB27495">
        <property type="protein sequence ID" value="KJB27495"/>
        <property type="gene ID" value="B456_005G250300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SVUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITMAICM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB27495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="113" mass="12992" checksum="B9EC7DDC1B2F39CA" modified="2015-04-29" version="1">MFIGNTYLHILKVLQFSEIFLFFLFRSIHLSKITMAICMPRIISSKKVPKGYFAVYVGENQKRFVIPVSFLNQPLFQDLLGMSEQEFGYSPLTGGITIPCNEDIFLVVTSRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAF5</accession>
    <name>A0A0D2SAF5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G034500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAF5"/>
    <dbReference type="Gramene" id="KJB28210">
        <property type="protein sequence ID" value="KJB28210"/>
        <property type="gene ID" value="B456_005G034500"/>
    </dbReference>
    <dbReference type="OMA" id="NCICSAK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB28210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="386" mass="40509" checksum="84B652FDC34369F8" modified="2015-04-29" version="1">MSTTCINTTTANTSTLPSYITSNTSATTSTTISTNLSLSSYFTFKTNFSLALTSVTSFFITTLCCAKSTTCTSCSTTNTFGMACSPSTNISATTSTTISTKACSHSASKPKLKTTPTSYTTTTTFVPSYFTFRPIFSFTLTSSTNFSITIFFTAMSATCINTTTTKSSTLPSYLTSNTSATTSTNLSLSSPFTFSSHTTTTTTFSSSSSCTNNVSTTLKSASYSCVWSYFTFKTSFSLTLSRITSFAIITLCSTKTTTCTSCTTTNTFEMASCPSTNISATTSNPISTKSCSYSTSKPKMKSTPSSHTTTATTTCTSTTTTTVTATCTSTTTTAASYTFTTATFTSCACCSSCASNVSTTLKSTSYSCVCSFTTMPSFTSGPRTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAT3</accession>
    <name>A0A0D2SAT3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G101700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAT3"/>
    <dbReference type="Gramene" id="KJB41379">
        <property type="protein sequence ID" value="KJB41379"/>
        <property type="gene ID" value="B456_007G101700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802723"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAHDQRT"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000497">
        <property type="entry name" value="RING-H2 finger protein ATL73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF10">
        <property type="entry name" value="BRASSINOSTEROID-RESPONSIVE RING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="90"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB41379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="168" mass="19444" checksum="1BBD1E509DE509EA" modified="2015-04-29" version="1">MGFPVGYTEVFLPKLFVHMLWFLGFIRCLIVTLFSYLGLSDFLEPDTVWPDNRTRITPENPPVSALLIREILPVIKFEELVVVGDPPESCAVCLYEFEGGEEIRWLRNCRHVFHRACLDRWMDHDQKTCPLCRTPFVPDELQDEFNQRLWSASGVGDLHSEYVSVPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDN3</accession>
    <name>A0A0D2SDN3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G150700</name>
        <name evidence="11" type="ORF">Gorai_018778</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB42399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDN3"/>
    <dbReference type="STRING" id="29730.A0A0D2SDN3"/>
    <dbReference type="Gramene" id="KJB42399">
        <property type="protein sequence ID" value="KJB42399"/>
        <property type="gene ID" value="B456_007G150700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RANYNAY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF94">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="200"/>
            <end position="223"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="244"/>
            <end position="262"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="344"/>
            <end position="364"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="50"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB42399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0590059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="499" mass="53354" checksum="99740227EDDF3E0F" modified="2015-04-29" version="1">MAGFTCSAADLRPLLGTAANATAAAEYICNAFDTVSNKLVAATYAIDNTYLLFSAYLVFSMQLGFAMLCAGSVRAKNTMNIMLTNVLDAATGSLFYYLFGFALAFGSPSNGFVGRHFFGLEKYPSPSGDYSFFLYQWSFAIAAAGITSGSIAERTQFVAYLIYSSFLTGLVYPIVSHWFWSTDGWASPVREGHLLFGSGVIDFAGSGVVHMVGGIAGLWGALVEGPRMGRFDGDGKPVLLRGHSGTLVVLGTFLLWFGWYGFNPGSFLSILKTYEHTNYSSYYGQWSAIGRTAVTTTISGSSAALTTLFGKRLLTGHWNVTDVCNGLLGGFAAITGGCSVVDPWAAIICGFIAAWVLIGCNKLAEMLKYDDPLEAAQLHGGCGAWGIIFTALFAKKDYVNEIYPGKPGRPHGLLMGGGARLLAAHLIQILVVIGWVSVTMGSVFWLLKVFGLLRISADEEMAGLDVTSHGGLAYAYHDENNDQSEKNSFPIANMDGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SEH2</accession>
    <name>A0A0D2SEH2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="13">Photosystem II CP47 reaction center protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G110500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2SEH2"/>
    <dbReference type="Gramene" id="KJB29615">
        <property type="protein sequence ID" value="KJB29615"/>
        <property type="gene ID" value="B456_005G110500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRV6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLAAIWH"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.680.10">
        <property type="entry name" value="Photosystem II CP47 reaction center protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000932">
        <property type="entry name" value="PS_antenna-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036001">
        <property type="entry name" value="PS_II_antenna-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00421">
        <property type="entry name" value="PSII"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF161077">
        <property type="entry name" value="Photosystem II antenna protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-0157">Chromophore</keyword>
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    <keyword evidence="3" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="9" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB29615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="52414" checksum="749FC07B79503E96" modified="2015-04-29" version="1">MGLPWYRVHTVVLNDLGCLLFVHIMHTALVAGWVSSMALYELVIFYPSDHVLDPMWRQGMFVLPFMTRVAGAHILFSSLCFLAAIWHWVYWDLEIFCDKRTGKPSLDLPKIFEIHLFLSGVACFGFGTFHVIGLYGPGIWVQPVNPVWGVEGFDHFVPRGIASHHIAARTLGILAGLFHLSVRPPQRLYKGLRMGNIETVLSISIVVIFFAAFVVAETMWYGSETTPIKLFGPSRYQWDQGYFQQEIYRRVSAGLAENQSLLEAWSKIPEKLAFYDYIGNDPAKGGLFKMGSMDNGDVIAVGWLGHPIFRDKDERELFVHCMPTFVFETFLVVLVEGDRIVRADTPFKRAESKYSVEPVGVTTEFYYGELNGVSYSDPATVKKYARHRATLKSDGVFRNSSTNWFTFGHASFALLFFFGHIWHGARTLFKDIFDGIDPNLDAQVEFGAFQKLGDPTTRRQVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJZ8</accession>
    <name>A0A0D2SJZ8_GOSRA</name>
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        <recommendedName>
            <fullName evidence="14">Peptidase M50 domain-containing protein</fullName>
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        <name evidence="15" type="ORF">B456_007G256500</name>
        <name evidence="16" type="ORF">Gorai_019518</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJZ8"/>
    <dbReference type="STRING" id="29730.A0A0D2SJZ8"/>
    <dbReference type="Gramene" id="KJB44504">
        <property type="protein sequence ID" value="KJB44504"/>
        <property type="gene ID" value="B456_007G256500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804416"/>
    <dbReference type="eggNOG" id="ENOG502QUAP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAIDPPD"/>
    <dbReference type="OrthoDB" id="195057at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06160">
        <property type="entry name" value="S2P-M50_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044838">
        <property type="entry name" value="EGY1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31412:SF0">
        <property type="entry name" value="ZINC METALLOPROTEASE EGY1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="14">
        <location>
            <begin position="312"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="69"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB44504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0590826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="559" mass="60533" checksum="8E488C3EFB8E90E7" modified="2015-04-29" version="1">MGTLTSFSFNAVNLRFTSSSIFRQRVGVQVFGSRKLNTKLCYLIPKEVSREKFLKFRCFCATNNSNNDADYTQNDGEIKEDSSNTASSTESTVTTASPPEDKAVQEKRTSNELPPSLSSRPPNIAPLGSVYNDFQIDSFKLMELLGPEKVDPADVKLIKDKLFGYSTFWVTKEEPFGDLGEGILFLGNLRGKREDVFTKLQTQLAEIVGDKYNLFMVEEPDSEAPDPRGGPRVSFGLLRKEVSEPGPTTLWQYVIAILLFLLTIGSSVELGIASQINRLPPEVVKYFTDPNAVDPPDMELLYPFVESALPLAYGVLGVLLFHELGHFLAAFPKKVKLSIPFFIPNITLGSFGAITQFKSILPDRSTQVDISLAGPFAGAALSFSMFAVGLLLSSNPDAAGDLVQVPSMLFQGSLLLGLISRATLGYAAMHAATVSIHPLVIAGWCGLTTTAFNMLPVGCLDGGRAVQGAYGKGALVGFGLTTYTLLGLGVIGGPLSLPWGLYVLICQRTPEKPCLNDVTEVGTWRKTAVTVAVFLVVLTLLPVWDELAEELGIGLVSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLD0</accession>
    <name>A0A0D2SLD0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Snakin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G024200</name>
        <name evidence="5" type="ORF">Gorai_006995</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GASA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLD0"/>
    <dbReference type="SMR" id="A0A0D2SLD0"/>
    <dbReference type="STRING" id="29730.A0A0D2SLD0"/>
    <dbReference type="Gramene" id="KJB63918">
        <property type="protein sequence ID" value="KJB63918"/>
        <property type="gene ID" value="B456_010G024200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774703"/>
    <dbReference type="eggNOG" id="ENOG502S46W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICCEACH"/>
    <dbReference type="OrthoDB" id="847210at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003854">
        <property type="entry name" value="GASA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201">
        <property type="entry name" value="EXTENSIN, PROLINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23201:SF141">
        <property type="entry name" value="GIBBERELLIN-REGULATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02704">
        <property type="entry name" value="GASA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989129" description="Snakin-1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB63918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0597180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9646" checksum="BC7B4B76186B45B1" modified="2015-04-29" version="1">MKMVLVLFLLVSLALSSCFFEVSIAGSDFCDSKCAVRCSKAGVQDRCLKYCGICCEKCHCVPSGTFGHKDECPCYRDMKNSKGKSKCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUH7</accession>
    <name>A0A0D2SUH7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G323300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUH7"/>
    <dbReference type="Gramene" id="KJB45726">
        <property type="protein sequence ID" value="KJB45726"/>
        <property type="gene ID" value="B456_007G323300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTHYINS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF217">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RPS2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="7">
        <location>
            <begin position="134"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="375"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="8">
        <location>
            <begin position="767"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB45726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="933" mass="107194" checksum="92834748BF3D49C5" modified="2015-04-29" version="1">MDFISRNASKYLKYQREFTEYVDDFKQAQADLHAKEVDIQQQLKDEHHFGKMPKLEVERWFKKVEEKLTHAQHVEDKVSKGKYLFRSCLGKLVDESTQAMKEVHAEGRFSGSLMVNDPSTIAVNLPTPENLSYLMGDEVGMIGVCGMGGIGKTTIMKDVHNRLLKESKFRKLIWVTVSQNFDIQRLQKNITCQLKGNLSDDEDTIIRAGKLWEMLKGQGSYVLILDDVWKSFSLEDVGILKPTSNNGCKLVLTTRSERVVRSMGFKKVQVPCLSMEEAMDLFLSKVGLDILADPTLESFLKIVVRECDGLPLAIVTLAGCMRGVTDPHVWENAIDELRGYIRNIHDVEDKVYGCLKFSYDRLKQRDQECFLYCALYPEDYAIIKEELIEHWLIEGLIDEMESRKSMESSGYSILQNLEENCLLERAERDSYNSRFIYKKTAHMHDVVRDMALHITRKKFMVKARMQLKELPKEEEWSEDLEKVSLMHNFISTIPQTIKFPKFPKLTTMLLSHNSLKEIPESFFHHFPNLMILDLSHNPFESLPESISTLEKLTALLLIGCYNLESLPSVLKLQALKKLDLEGSGVKEIPQDLEMPVNLRYLNLKGTLHLKEIPKGLLSKLWRLQFLAIRSTLINADDMRELNKLEVFEGCFFNVGDLSKYAAQRKMLYKYSILVCPWNNPMLYQHVVLPYDIQQLNLKLCKGVRSLEDIGLRDATDLKECEVDCCDKLEAVFSSKCHQLQTLESLILIRLRNLNVIVGAGVEESSVGTFSSLKVITLVKCEKIKKMFSADWVLPNLENLTVSTCSKLKEIIAEPQKEGTGAFKFSVPKLKRLTLCSLPELKSICGENGVIVCDSLECIEIVCEQVKRIPLYLPQLQIDDEGKPTPSNPLKEIRVHSTYWWESVEWDHPNFDVKKVVKPLVLNWLDRSLDWRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SYG4</accession>
    <name>A0A0D2SYG4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G103700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="D-ALANYL-D-ALANINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21581:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB49164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="363" mass="41726" checksum="11C5F6AC220E2EC2" modified="2015-04-29" version="1">MDEPSPTVDPLTNQFGSLNDLSHELASLQDLAMRGSWRSILDKVSGARSLDLLAKPHDHLIYLSYNVLALTKLRRFSDASNELDSLHDFNSHHYKYETYPKLYHTRSGSMVPFSLRFINAQLPFKLGNRQEGLDRFYLLLNFIRQKIKDKGIHSLQESVKIWRKREVFVLHCLIGHHLGAKEFNLCLDLIRDLINHDYLDPVLVSKLGYIQMQIGDFEGAKGSFHRVETMLNERKNDDSSALSEVEFRNLVNRNKALVFLVGKDYVSAVREYEECMERDPADVVAVNNKALCLMYLRDLSDSIKVLENSLERVPTVALNETLVVNLCSMYELAYVNHSEIKRTLSNWIARVALDDFDASCTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2Y4</accession>
    <name>A0A0D2T2Y4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZF-HD dimerization-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G092000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2Y4"/>
    <dbReference type="STRING" id="29730.A0A0D2T2Y4"/>
    <dbReference type="Gramene" id="KJB48886">
        <property type="protein sequence ID" value="KJB48886"/>
        <property type="gene ID" value="B456_008G092000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763549"/>
    <dbReference type="eggNOG" id="ENOG502QRG0">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000257">
        <property type="entry name" value="Zinc-finger homeodomain protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006455">
        <property type="entry name" value="Homeodomain_ZF_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006456">
        <property type="entry name" value="ZF_HD_homeobox_Cys/His_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01565">
        <property type="entry name" value="homeo_ZF_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01566">
        <property type="entry name" value="ZF_HD_prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948:SF157">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04770">
        <property type="entry name" value="ZF-HD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51523">
        <property type="entry name" value="ZF_HD_DIMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZF-HD dimerization-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB48886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="231" mass="26132" checksum="454D63F144BB7AE5" modified="2015-04-29" version="1">MEFEEQEEEMGLAPSYNSLVNSTAVKMSDAEPGSITPTGQQQQQQRKRRYRECLKNHAVGIGGHAVDGCGEFMPAGTEGTLDALKCAACNCHRNFHRKETEPNSPNTFPSTDLYFHQPTQFTPYFRAPTGYLHVAGQQRLLALPSTSGGGGGHSREDQEDVSNQGSSRKRFRTKFTHDQKEKMLELAERIGWRIQKHDELLVQQFCNENGVKRQVFKVWMHNNKHTLGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5B5</accession>
    <name>A0A0D2T5B5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Calnexin homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_006G273500</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5B5"/>
    <dbReference type="STRING" id="29730.A0A0D2T5B5"/>
    <dbReference type="Gramene" id="KJB38815">
        <property type="protein sequence ID" value="KJB38815"/>
        <property type="gene ID" value="B456_006G273500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38822">
        <property type="protein sequence ID" value="KJB38822"/>
        <property type="gene ID" value="B456_006G273500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800852"/>
    <dbReference type="eggNOG" id="KOG0675">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000048">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073:SF1">
        <property type="entry name" value="CALNEXIN 14D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11073">
        <property type="entry name" value="CALRETICULIN AND CALNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00804">
        <property type="entry name" value="CALRETICULIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00805">
        <property type="entry name" value="CALRETICULIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="14 17" id="KW-0143">Chaperone</keyword>
    <keyword evidence="12 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 17" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354298" description="Calnexin homolog" evidence="17">
        <location>
            <begin position="25"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="207"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="490"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="509"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR601580-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB38815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="60684" checksum="4D27676DE97976C1" modified="2015-04-29" version="1">MMIMTRYALLLLLAFASLQLLCFAADDDVVFYDSFEESFDGRWIVSDKDDYKGVWKHSKSEGHDDYGLLVSEMAKKYAIVKELDEAVNLKDGTTVLQFETRLQGGLECGGAYLKYLRPQDAGWKPKEFDNESPYSIMFGPDKCGATNKLHFILKHKNPKSGEYIEHHLKYPPSVPSDKLTHVYTAILKPDNEVSILIDGEEKKKASFLSAEDFEPPLIPSKTIPDPDDKKPEDWDERAKIPDPDAVKPEDWDEDAPMEIEDEEAVKPESWLDDEPEEIDDPEATKPEDWDDEEDGEWEAPKIENPQCEIAPGCGEWKRPMKRNPAYKGKWSPPLIDNPSYKGIWKPQEIPNPNYFELEKPDFDPIAAIGIEIWTMQDGILFDNILIAKNDKVAESYRETTWKPKFEVEKEKQKAEDEAADSARLAGFQRKVFDVLYKVADIPFLSKYKHQILDLIEHAETQPNLTIGVLVSIVVIILTIFFKLIFGGKKQPRVEKKPEVAKTSNGEGSSGEKAEEAEKEEAAAAPRRRRRDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB44</accession>
    <name>A0A0D2TB44_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G007000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TB44"/>
    <dbReference type="STRING" id="29730.A0A0D2TB44"/>
    <dbReference type="Gramene" id="KJB53834">
        <property type="protein sequence ID" value="KJB53834"/>
        <property type="gene ID" value="B456_009G007000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHIHELR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1185">
        <property type="entry name" value="DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="4">
        <location>
            <begin position="188"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="477" mass="54401" checksum="3847394AD6450898" modified="2015-04-29" version="1">MAGVGKTTLAKVIYQTSEQKFKNRAWIFVPSKYRMRELLLGLLENLMSVGEETLKLDDVKLAEKLRKLLLGKRYLVVIDGVEKAQLWQEFEKNKVFPDHQNGSRVLLTTCSNGVALLASSSPIRTHHLQSLGGKERSELLEKLVFKDGSCPEHLVNKLQPSVMSSHLPLSLWLHTDHLKECFLYLGAYPSDCEIPARQIINLWIAEVLAKGNNEASAEQIAERYLDELIDLCLIEDHIHELRYILSDPNYLSHLHSLLCFHNNSSLDSDEFTLKFDHLQNISALDLGSTYVTKLGGSIKGSLVLKYLTINHPSLKRLPSSLCNLSDQQTLDIKNTCVKCLQCGIWEMQKLRHLSVPHQTTLPKSSDNGTFPTRLVKVTLVRTGLVADDVMRTLEKLGHLQVLRLQQEIFIQTWRMGDGAMGSLEELTLSRCHEQKSLPHQLWQLHDMHQIKVNSPSHCLERELEQLRAEQRKVHIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TBD9</accession>
    <name>A0A0D2TBD9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G012900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TBD9"/>
    <dbReference type="Gramene" id="KJB53929">
        <property type="protein sequence ID" value="KJB53929"/>
        <property type="gene ID" value="B456_009G012900"/>
    </dbReference>
    <dbReference type="OMA" id="FFSNFPC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB53929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="8432" checksum="7F5F34E9D0130730" modified="2015-04-29" version="1">MDEACVARDDDLDHLVLAVAHGGLVQEEEHGLEEDDQHVADLEAEHGVADVGGGDDEDGGGLVVVDYAFFLFFSNFPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCF4</accession>
    <name>A0A0D2TCF4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G256100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCF4"/>
    <dbReference type="Gramene" id="KJB52215">
        <property type="protein sequence ID" value="KJB52215"/>
        <property type="gene ID" value="B456_008G256100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB52216">
        <property type="protein sequence ID" value="KJB52216"/>
        <property type="gene ID" value="B456_008G256100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765321"/>
    <dbReference type="eggNOG" id="ENOG502S3KG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSSRWSY"/>
    <dbReference type="OrthoDB" id="421474at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47721">
        <property type="entry name" value="OS01G0235100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47721:SF2">
        <property type="entry name" value="OS01G0235100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB52216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="170" mass="18050" checksum="99C16A42CE603A8B" modified="2015-04-29" version="1">MAMALLSAPPPPSHKTSFFQPPYTTSFRSIAFIKYPYKLTAASSTTPTAEDKPTASPDGVAVESESATMVAVEDPPFRGCKACGKEELERGCNGEGRIQGGIATVPGFGWWPIKAYRPCPAFVASGGRYTRRGQSMDEVASGGGGRVSSIGISDEAESSKIKQGRKKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TE93</accession>
    <name>A0A0D2TE93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_011G267200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TE93"/>
    <dbReference type="STRING" id="29730.A0A0D2TE93"/>
    <dbReference type="Gramene" id="KJB74013">
        <property type="protein sequence ID" value="KJB74013"/>
        <property type="gene ID" value="B456_011G267200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QU9Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REFSACE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090447">
        <property type="term" value="F:glycerol-3-phosphate 2-O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010143">
        <property type="term" value="P:cutin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056462">
        <property type="entry name" value="HAD_RAM2/GPAT1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486">
        <property type="entry name" value="ANCIENT UBIQUITOUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15486:SF54">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23270">
        <property type="entry name" value="HAD_RAM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="12">
        <location>
            <begin position="221"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB74013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="405" mass="45575" checksum="7C55B9385FDBD938" modified="2015-04-29" version="1">MKYSIVSEFEGTLLKDQDPFSYFMLVAFEASGFIRFTLLLLTWPVIWFLDVLGVGDVGLKLMVFVATVGLQFYMDDVDMEAWRVFSRYDKRVVVTKMPRIMVERFVKEYLRADVVVGSELVVNRFGFATGFIDSDISSISSKVAKLFVNDEPSLGLGRATSSFQFFSICKMPFIILLSLIRIIIGEMLPLRIMLYLAPLTGCKIVVKGKPPSPISSSNSGVLFVCTHRTLMDPFVLSIVLMRKIPAVTYSLSRLSEILSPIPTVRLTRIKEVDAQKFKQELSKGDLVVFPEGTTCREPFLLRFIPVAMNNKVGFFHATTASGWKALDPIFFFMNPRPFYEVTFLDQLPAKATCSSGKSPHDVANYVQRILAATLGFECTNFTRKDKYIALAGNDKTVSCTSLETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TEF2</accession>
    <name>A0A0D2TEF2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G057600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. In addition to ssRNA and dsRNA, binds dsDNA, but not ssDNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with ALY2 and MOS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TEF2"/>
    <dbReference type="SMR" id="A0A0D2TEF2"/>
    <dbReference type="STRING" id="29730.A0A0D2TEF2"/>
    <dbReference type="Gramene" id="KJB54999">
        <property type="protein sequence ID" value="KJB54999"/>
        <property type="gene ID" value="B456_009G057600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769340"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="279"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB54999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="428" mass="48488" checksum="87DC9FD9EA3B492E" modified="2015-04-29" version="1">MGETRDNDAYEEELLDYEEEEEKAPDSVTAKVNGEGGKKGYVGIHSSGFRDFLLKPELLRAIVDSGFEHPSEVQHECIPQAILGMDVICQAKSGMGKTAVFVLSTLQQIEPSPGQVIALVLCHTRELAYQICHEFERFSTYLPDIKVAVFYGGVNIKVHKDLLKNECPHIVVGTPGRILALTRDKDLSLKNVRHFILDECDKMLESLDMRRDVQEIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDPMEIYVDDEAKLTLHGLVQHYIKLSEMEKNRKLNDLLDALDFNQVVIFVKSVNRAAELNKLLVECNFPSICIHSGMSQEERLTRYKGFKEGHKRILVATDLVGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLAITFVSSASDSDVLNQVQERFEVDIKELPEQIDTSTYMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2THI1</accession>
    <name>A0A0D2THI1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G107000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2THI1"/>
    <dbReference type="STRING" id="29730.A0A0D2THI1"/>
    <dbReference type="Gramene" id="KJB56124">
        <property type="protein sequence ID" value="KJB56124"/>
        <property type="gene ID" value="B456_009G107000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770591"/>
    <dbReference type="eggNOG" id="ENOG502S9SR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFGKQFR"/>
    <dbReference type="OrthoDB" id="1895233at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37720">
        <property type="entry name" value="OS10G0481400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37720:SF2">
        <property type="entry name" value="OS10G0481400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB56124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="117" mass="13454" checksum="B0244C697DBD2E4A" modified="2015-04-29" version="1">MVLDIQKENPKFIFLRLIMKSKKISSNAKFLTMISVLAQERLLGAALGTALTGIVVFEQRKRIYESISDYQSQLAFQSQIKEPIFGKKSRSEFALLWNKAVDQIFVPVIESISSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKG5</accession>
    <name>A0A0D2TKG5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G078300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKG5"/>
    <dbReference type="Gramene" id="KJB76223">
        <property type="protein sequence ID" value="KJB76223"/>
        <property type="gene ID" value="B456_012G078300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781010"/>
    <dbReference type="eggNOG" id="ENOG502QS03">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWDRHLM"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050898">
        <property type="entry name" value="Plant_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147:SF1">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB76223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="442" mass="48315" checksum="D45AFFFCC7676840" modified="2015-04-29" version="1">MGSSSVHVNEATIVTPSEPTPTGVLSLSALDSQLFLRFTIEYLLVYKPHPASDPRATTARLKAALAKALVPYYPLAGRVRASSADASTGLEVVCRAQGALFIEAVSDLNVHEFDNAPRFVTQWRKLLSFHVADVLKGAPPLVVQLTWLKDGNAALGVGFNHCLCDGIGSAEFLNSFADFASTSQSKFPPNPIWDRHLLNPPPFKPSTDNNNNSSSHPEFNRVPDLCGFMSRFSNERLVPTSFIFDKTSLNELKKIVFSTSRVGESNYTSFEVLSAHIWRSWARALNLPSNQILKLLFSINVRERVKPSLPSGYYGNAFVLGCAQTSVKDLTEKGLGYAAMLVKRAKERVDGEYVKSVVESVSQEGASPDSVGVLVLSQWSRLGLEKVELGGMGKPIHVGPICCDRYCLLLPVFNQTDAVKAMVAVPTTAAQRYEDLLRSFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPU4</accession>
    <name>A0A0D2TPU4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glabrous enhancer-binding protein-like DBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G233500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GeBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPU4"/>
    <dbReference type="STRING" id="29730.A0A0D2TPU4"/>
    <dbReference type="Gramene" id="KJB58974">
        <property type="protein sequence ID" value="KJB58974"/>
        <property type="gene ID" value="B456_009G233500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RQE9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHGMALN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007592">
        <property type="entry name" value="GEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053932">
        <property type="entry name" value="GeBP-like_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31662">
        <property type="entry name" value="BNAANNG10740D PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31662:SF33">
        <property type="entry name" value="DNA-BINDING STOREKEEPER PROTEIN TRANSCRIPTIONAL REGULATOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04504">
        <property type="entry name" value="GeBP-like_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glabrous enhancer-binding protein-like DBD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB58974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="280" mass="31138" checksum="F0BCBFD61FAB6F53" modified="2015-04-29" version="1" fragment="single">EVTSSEEEEGSSTEEDDEEDPKTQSTPLIQKSRPTRKPDSESESDTAVPIIKPIAIATKPMKGILSAKKCRSSKPLASLVRASSSKRAGEFAKEKRPKKKVRKEGLAIAPVVEEVKKTGEDAKKLLFQRLFSEDDEIALLKSMLAYSAKKGADPCADMNGFYDFVKKLIHIDKKKFKNNAGKDKGEDRTFSKAHEQNAFELSKNIWGKEGISGKVESSTDKKIDELSKSFNSLLDKKFGVFDMEVEVVEVGLDMVDGEKKTALEAKWRKLQMVQLAGFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTY3</accession>
    <name>A0A0D2TTY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G057100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTY3"/>
    <dbReference type="STRING" id="29730.A0A0D2TTY3"/>
    <dbReference type="Gramene" id="KJB46840">
        <property type="protein sequence ID" value="KJB46840"/>
        <property type="gene ID" value="B456_008G057100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763157"/>
    <dbReference type="eggNOG" id="ENOG502S4G0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIAVFAI"/>
    <dbReference type="OrthoDB" id="665742at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01959">
        <property type="entry name" value="nsLTP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033872">
        <property type="entry name" value="nsLTP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33214:SF44">
        <property type="entry name" value="NON-SPECIFIC LIPID TRANSFER PROTEIN GPI-ANCHORED 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252037" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="3">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB46840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="96" mass="9997" checksum="46B65F0FF049861A" modified="2015-04-29" version="1">MKRVSFVALCVVALAVVLFSGESRTAEAVTCNPVELAPCSPALTSSSPPSSACCSKLKAQQPCLCGYLKNPSLKQYVNSPNAKKVASTCGVPYPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TV54</accession>
    <name>A0A0D2TV54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G248300</name>
        <name evidence="8" type="ORF">B456_009G315000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB11229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB60609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TV54"/>
    <dbReference type="SMR" id="A0A0D2TV54"/>
    <dbReference type="STRING" id="29730.A0A0D2TV54"/>
    <dbReference type="Gramene" id="KJB11229">
        <property type="protein sequence ID" value="KJB11229"/>
        <property type="gene ID" value="B456_001G248300"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB60609"/>
        <property type="gene ID" value="B456_009G315000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767318"/>
    <dbReference type="KEGG" id="gra:105770983"/>
    <dbReference type="KEGG" id="gra:105799810"/>
    <dbReference type="eggNOG" id="KOG1749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWHDNDY"/>
    <dbReference type="OrthoDB" id="939188at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00077543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB11229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB60609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="15737" checksum="D687DA460E0811F0" modified="2015-04-29" version="1">MGKTRGMGAGRKLRTHRRRQRWADKAYKKSNLGNEWKKPFAGSSHAKGIVLEKIGIEAKQPNSAIRKCARVQLIKNGKKIAAFVPNDGCLNYIEENDEVLIAGFGRKGHAVGDIPGVRFKVVKVSGVSLLALFKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZI0</accession>
    <name>A0A0D2TZI0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">L18 ribosomal protein Heart Stopper</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G116100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
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        <property type="gene ID" value="B456_013G116100"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000004">
        <property type="entry name" value="50S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899:SF5">
        <property type="entry name" value="RIBOSOMAL L18P_L5E FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002253030" description="L18 ribosomal protein Heart Stopper" evidence="4">
        <location>
            <begin position="17"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB80808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23171" checksum="25DA737A10AC0AFC" modified="2015-04-29" version="1">MLLYTICFWFSGGVVCKMLKQAIWKVLSKRVVSESGDKLLLPCLYLPTTSFHAGQVHCSPRSFFGVEDFLDDDNSKPYTYQKGKKSKNPNKHVSFKQRTEAYMEPFTLDVFISKRFVSASVTHRVTCKQVAVAGTNSKDIKAVLRSRSDIPACLAIGRILAERAREADVYTASYTPRERDKFEGKIRAVVQSLIDNGIDIKVYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7Q3</accession>
    <name>A0A0D2U7Q3_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G2727001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7Q3"/>
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        <property type="protein sequence ID" value="KJB83878"/>
        <property type="gene ID" value="B456_013G2727001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB83878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="60" mass="6762" checksum="C9620078E572954B" modified="2015-04-29" version="1" fragment="single">PERIQRHYIVILSTISVFGIFGLPCLISVLSNKPLPLPLPLHTFQRLTSDQASFLPSFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCT6</accession>
    <name>A0A0D2UCT6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G141500</name>
        <name evidence="2" type="ORF">Gorai_011835</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCT6"/>
    <dbReference type="STRING" id="29730.A0A0D2UCT6"/>
    <dbReference type="Gramene" id="KJB53420">
        <property type="protein sequence ID" value="KJB53420"/>
        <property type="gene ID" value="B456_009G141500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7T9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1002043at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36755:SF1">
        <property type="entry name" value="OS06G0149300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36755">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB53420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0594952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="92" mass="9435" checksum="46EE91BD9E12196E" modified="2015-04-29" version="1">MTVTVIQLCSEFRQLNQNFFDGYLNKMAVKPTVALRAFLVGGVAVFAKVAGAMKAAGGAKLGAAAAAMTVAASAAMTGSKQEQKDGSKQPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFQ1</accession>
    <name>A0A0D2UFQ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G195600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2UFQ1"/>
    <dbReference type="Gramene" id="KJB67529">
        <property type="protein sequence ID" value="KJB67529"/>
        <property type="gene ID" value="B456_010G195600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771528"/>
    <dbReference type="eggNOG" id="KOG2824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLHENGE"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669:SF36">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23733">
        <property type="entry name" value="GRXCR1-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB67529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="256" mass="28146" checksum="62D19C794E4E0FD5" modified="2015-04-29" version="1">MFPHWLLRSPPNTATSTPKSPSHFSSSSLKDINAILQEDQPFQSYSKSPQKPSIFHRVTLSTSVLRAWAAAAASAAQTHYHAPLSPQPSVTLPYADHRVVLYFTSLRVVRRTFEDCKAVRSILRGFGVPIDERDLSMDSDFIGELQGISGQNEIKSFTLPLVFIGGKYVGGAEEIKRLHECGELKNLIGGSPVAVGSSVCDLCQGMRFVVCRQCNGSHKIYFEKSGFRSCNDCNANGLVRCPSCSPGHRRVSYSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJD3</accession>
    <name>A0A0D2UJD3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF679 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G182100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant DMP1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJD3"/>
    <dbReference type="STRING" id="29730.A0A0D2UJD3"/>
    <dbReference type="Gramene" id="KJB68814">
        <property type="protein sequence ID" value="KJB68814"/>
        <property type="gene ID" value="B456_011G182100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775798"/>
    <dbReference type="eggNOG" id="ENOG502RXHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFACHAT"/>
    <dbReference type="OrthoDB" id="1928191at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009838">
        <property type="term" value="P:abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010256">
        <property type="term" value="P:endomembrane system organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007770">
        <property type="entry name" value="DMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621:SF34">
        <property type="entry name" value="DOMAIN MEMBRANE PROTEIN 2, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31621">
        <property type="entry name" value="PROTEIN DMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05078">
        <property type="entry name" value="DUF679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB68814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="190" mass="20981" checksum="7CE0538D013AB610" modified="2015-04-29" version="1">MAFDLLCSKMGNLVKFLPTGTVFIFNFLNPVLTDNGNCKTPLNKQSAAILIVLCGFTCSFSCFTDSYKDRDGKTHYGIATFKGLWPSPSSFESDLVNLSSYKLRLSDFVHAFFSSMVFAVLVLLEPNTVKCFYPSLSTNSKALICLIALPPIALVVSLAFMWFPNKRHGIGHPSIEHSSNKTNLLLPHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJK3</accession>
    <name>A0A0D2UJK3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G232600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJK3"/>
    <dbReference type="STRING" id="29730.A0A0D2UJK3"/>
    <dbReference type="Gramene" id="KJB68216">
        <property type="protein sequence ID" value="KJB68216"/>
        <property type="gene ID" value="B456_010G232600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774108"/>
    <dbReference type="eggNOG" id="ENOG502S28R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPQNDVE"/>
    <dbReference type="OrthoDB" id="431691at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_bL34_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF12">
        <property type="entry name" value="RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16198" checksum="22C292BEA1AAF846" modified="2015-04-29" version="1">MATKSLIRNGAMLMNRVLVKQALNPNPITNNRVLNQGIQITPQLFPSLSKPKLEIPHLPRNDVDSLSEVSSTGFLYPFGLPSLRFFLPDGDSSSEPMLLFPKRTYQPSTIRRKRNHGFFARKATKGGRRVIARRIAKGRSRITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKN6</accession>
    <name>A0A0D2UKN6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_011G014200</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKN6"/>
    <dbReference type="STRING" id="29730.A0A0D2UKN6"/>
    <dbReference type="Gramene" id="KJB69279">
        <property type="protein sequence ID" value="KJB69279"/>
        <property type="gene ID" value="B456_011G014200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776092"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFDGQQD"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000015">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000056">
        <property type="entry name" value="calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="94"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="431"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="503"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB69279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="551" mass="61955" checksum="5CCD1006A953D088" modified="2015-04-29" version="1">MGCFSSKHKPSDPPSMPTTQPKQVQTQEVSMPQTRQPQQVQTQKVSVPEAQVPQTRQPQAVSVPLKPSAASTRPIQTMEDTVLGKPLEDIKQYYKLGKELGRGQFGITYLCTENSTGNTYACKSILKRKLRSKQDREDIKKEVQIMQHLSGQPCIVEFRGAYEDRQSVHLVMELCAGGELFDRIIAEGHYSERAAAGIFKSVVNVVHICHFMGVIHRDLKPENFLLSSKDAGAMLKATDFGLSVFIEEGKRYRDIVGSAYYVAPEILRRSYGKEVDIWSAGIILYILLSGVPPFWAETEKGIFDAISEGKLDFESQPWPSISETAKDLVRKMLTKDPKKRLTSAQVLEHPWMREDGEASDKPIGSAVLSRLKQFRAMNKLKKLALKVIAENLSEEEIKGLKVMFTNMDTDKSGTITYEELKTGLARLGSKLSEAEVKQLMEAADVDGNGTIDYIEFISATMNRYRLDRDELLYKAFQYFDKDNSGYITKDELETAMKEYGMGDEASIRAVISEVDTDNDGRINYEEFCTMMRGGTQQTEKAFLDTINSSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULB9</accession>
    <name>A0A0D2ULB9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G024500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULB9"/>
    <dbReference type="Gramene" id="KJB69459">
        <property type="protein sequence ID" value="KJB69459"/>
        <property type="gene ID" value="B456_011G024500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777888"/>
    <dbReference type="eggNOG" id="ENOG502QUCU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPPLQGW"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000062">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000125">
        <property type="entry name" value="Protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF44">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE CLAVATA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253566" evidence="12">
        <location>
            <begin position="25"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="14">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="479"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="416"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB69459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="756" mass="82195" checksum="08757FC3002B5FD6" modified="2015-04-29" version="1">MGFVSWGIVRVGLLLVLTLPFSTGDTDPRDVSAINSLYTSLGSPPLLGWIPAGGDPCGEGWQGVSCVFSNITELRLSGLNLGGILDEGIGGFESILIMDLSHNQIGGSIPSNIPLTIKNLFLSGNQFNGSIPVTLSALTQLTQLFLDDNRLSDNIPDSFQELRSLVDLDLSGNNLTGQLPPSFGNLSSLTTLHLQNNKISGVLDVLQDLPLSDLNVENNILSGPIPPKLLNIPNFRKDGNPFNTTILPSPPAALPPFIAWAPSPLHGPPRGRPADGPSSSLVLPQWSKGRVFWTNKRVIVIAAAGIVTLIVLGVVLLLVLRCFRGNKDSNKHGANAYNSSSKKLNQVQKSSSQPAYQTEKVDKATVTRPMDGYGLESGDTGISPNLHDEQLLDANTRPASSRHQKNHEINKGGLDVKSLSIRPPLPPPLLPTVEEASVSPIMPTEVNGPGRSSRGRDSCSLDVTAFTIASLQQYTNSFAEENFIGEGMLGGVYRAELPDGKLLAIKKLDTRASRWKTDAEFLQLISTISKLRHPNIVELVGYCNEHGQRLLVYQYCRNGTLYDALHIDDEMHKKLSWNARVRVALGVARAIQYLHEACQPPIMHKNIKSVNILLDDKLAVRVSECGLAPLLSSGSTSEFSGSLFVSYGYAAPEIEFGSYTCQSDVYSLGVVMLELLTGRESFDRSRPLGEQFLVIWAIQQLHDIDALARMVDITLNGVYPVKSLSRFADIISRCVQSEPGFRPPISEIVQDLLHMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URU2</accession>
    <name>A0A0D2URU2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G097900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URU2"/>
    <dbReference type="STRING" id="29730.A0A0D2URU2"/>
    <dbReference type="Gramene" id="KJB70975">
        <property type="protein sequence ID" value="KJB70975"/>
        <property type="gene ID" value="B456_011G097900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB70976">
        <property type="protein sequence ID" value="KJB70976"/>
        <property type="gene ID" value="B456_011G097900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777475"/>
    <dbReference type="eggNOG" id="ENOG502QTVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEMQAIN"/>
    <dbReference type="OrthoDB" id="1926336at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160:SF1">
        <property type="entry name" value="PROTEIN GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23160">
        <property type="entry name" value="SYNAPTONEMAL COMPLEX PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01465">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00755">
        <property type="entry name" value="Grip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="4">
        <location>
            <begin position="719"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="102"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="357"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="670"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB70976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="796" mass="90975" checksum="DB4452DD66524F53" modified="2015-04-29" version="1">MSGEGVEEVIQVPETREDESLKPEAQFSETNGDLSKENAELDANLSSDDAHDKLLQTVTELKFENEVIKSQLESFKNFQSENDVPSQQTNVSGKETKFSADVKELHDRIESLSRELNEEKQTRVAAEEALKHLREVYTEADAKAQDLSGKLAEAQKKLDQEIKEREEKYNELDSKFNRLHKRAKQRIQEVQKEKDDLEARLREVNETLEQASSQQSGLQQELERTRQQANEALKAMDAERQQLRSANNKLRDNIEELRRSMQPKEDAIEALQQSILEKDQMLEDLQGLLQLADEKRQASLAEAAAKHQKNIESLEAQLADALSDRSKATETISSMQVLLAEKESKIAEMDAASTGEAARLRAVVESIKGELAHLKHEHEKEKESWEAASLAFKTKLEVAESNCIRAEIEAAKMRSQLELEASLQTQMLSTREAELAAAKEEVSRLEREFSSYKIRAHALLQKKDAELAAAKESEQTKALEDALKEVERELSLVSAERDTVRQELQDILRNHDKEIAERDAALENTKQQIKSLESNLHSANARHQSEKAAWEIDLKNLEETWRYRCEALTAENEASSGEDTRKELEETKLQYKRLKEEHASLRDLADKMIEEKDKEISRLLDDNKNLQRSLESRQLVDHTENYNTATQKQDAPNLNTSAAEQQILLLARQQAQREEELAQSQRHILALQEEIEELERENRLHSQQEAMLKEELRNMERSKRREGVDMTYLKNVIIKLLETGEVEALLPVVGMLLQFSPEEMQKCQQAYRTYTDVPSSPANEASGGPTLSLFSRFSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2US76</accession>
    <name>A0A0D2US76_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G227100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2US76"/>
    <dbReference type="Gramene" id="KJB58810">
        <property type="protein sequence ID" value="KJB58810"/>
        <property type="gene ID" value="B456_009G227100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VQICGRE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253699" evidence="10">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB58810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="139" mass="15257" checksum="46DDB539019A0895" modified="2015-04-29" version="1">MWFLGLFSCILLSFLNQFFGYRTEPLVITQITVQVATLPIGRFMASALPTAKFRIPGFGSRKFSLNPGPFNMKEHVLITIFANAGSAFGNGTVYAVLIVTIIKAFYGRSISFFGSWLLIITTQVGLLDVFLASGFNGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USS6</accession>
    <name>A0A0D2USS6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G138300</name>
        <name evidence="13" type="ORF">Gorai_005943</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0599736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USS6"/>
    <dbReference type="STRING" id="29730.A0A0D2USS6"/>
    <dbReference type="Gramene" id="KJB71709">
        <property type="protein sequence ID" value="KJB71709"/>
        <property type="gene ID" value="B456_011G138300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATHTIQD"/>
    <dbReference type="OrthoDB" id="4691307at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
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        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051502">
        <property type="entry name" value="RLP_Defense_Trigger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062:SF37">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0599736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="44298" checksum="76F28C26771C656D" modified="2015-04-29" version="1">MGLCNLVNLEFLDLSLNHLSGTIPSCSNLQKVLHVHLAKNELGGTLSDALFINSSLVTLDFSENNLTGRIPDWISTLPALSVFLLKANQLEGEFPVHLCRLQSLSILDLSQNKLSGHIPSCLSNLTLKPRSEKSYTGSTDFGLLLFDKIIVDMGLTIYNLIGDSETVKDYPFTFQEEEVEFSTKGARYTYKGNILELLSAIDLSCNQFTGIIPPGLGNLSEIRGLNVSHNNLTGPIPSTFSKLKQIESLDLSYNNLNGRIPPQLTEVTTLEVFSVAHNNLSGPLPDRKNQFETFEERSYKGNPLLCGPPLNKSCNECDSLGTPSASSSEEEHGFIDMGDFYISFGVSYAIIFLATIIVLYIDPYWRLACFHCVEDYSIACYFFIVDSLRRLLYFKRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTP9</accession>
    <name>A0A0D2UTP9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G251700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTP9"/>
    <dbReference type="Gramene" id="KJB59365">
        <property type="protein sequence ID" value="KJB59365"/>
        <property type="gene ID" value="B456_009G251700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771341"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNFASVP"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000060">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000356">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF221">
        <property type="entry name" value="MYB DOMAIN PROTEIN 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="18"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="65"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB59365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="339" mass="38267" checksum="510795C2B3001D87" modified="2015-04-29" version="1">MEDSGAASSDDVNKTCPRGHWRPAEDEKLRQLVEQYGAQNWNSIAEKLQGRSGKSCRLRWFNQLDPRINRRPFTEEEEERLLAAHHIHGNKWALIARLFPGRTDNAVKNHWHVIMARKQREQSKLCGKRSFQDAFSDSKLSSTGFSTSRKLARCQEAFSSRFGFGDSRFFDQFQNQGKDKIFSVSSTSTTSSPSWNFASSTMVASNNPSSAQLSIRDGKNHLLRSGSSYYSMDTSKLLDQSLYKYHSNASAYCSSFRNSSAFGIHNYRRVVPSPFGYLKLGDTFESNNGVMTKEFLSITDNAPKSANLRVSNSQQEQEDESDKPKDVPFIDFLGVGISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3H0</accession>
    <name>A0A0D2V3H0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BUB1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G078400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V3H0"/>
    <dbReference type="STRING" id="29730.A0A0D2V3H0"/>
    <dbReference type="Gramene" id="KJB76224">
        <property type="protein sequence ID" value="KJB76224"/>
        <property type="gene ID" value="B456_012G078400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779838"/>
    <dbReference type="eggNOG" id="KOG1166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQTFETD"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.430:FF:000005">
        <property type="entry name" value="Mad3/BUB1 homology region 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013212">
        <property type="entry name" value="Mad3/Bub1_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF2">
        <property type="entry name" value="OS11G0128700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08311">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00777">
        <property type="entry name" value="Mad3_BUB1_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51489">
        <property type="entry name" value="BUB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BUB1 N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB76224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="524" mass="60122" checksum="3D3DEEFADED6AFBE" modified="2015-04-29" version="1">MAEKSETMNSNLFSSIISEIKSYSGKDPLLPWLRGIKKIKDSLPPQILAEKLPRFLQKCTQTFEADRRYHDDLRYLRVWLQLMDFMDDPRLLLRRMEMNQIGTKRSLFYQAYALYYEKIKKFDEAEKMYHLGVQNLAEPVDELQKSYEQFLNRMERHKKKKIQRQEQKIARKPLQCTEFKENSEAVRMVEDSHKRSSALHTGKKVESKKGRALMERVLDEPRKVGNDDTVVVKFVDTAIVGKSEAEDACHHGLVDPTINMKEAMNAINSMFREPIETAPIGRRSSQRQLKEDCSLDIGFKVFDENLDSGINSSIQHQEKGLQGKAQICRPQEESFQIYIDDDEGNSEAGEGNDEIDNLEHIEVQNSGRVCNVFVFPNPNDLSPERSDDIGAKSSRRPKIQEDTVVHRFVGSTISDEPVVENVCHHGLVDPTINLKEAMQDINNMFGKPIDFVRAKRKKQDKAPVKQQDLGGFSILPDDDLEHQKPQSPSKSSGKLSDCDLFEPTMFTKEAMDDINKMFGMPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3X5</accession>
    <name>A0A0D2V3X5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_012G105000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V3X5"/>
    <dbReference type="SMR" id="A0A0D2V3X5"/>
    <dbReference type="Gramene" id="KJB76746">
        <property type="protein sequence ID" value="KJB76746"/>
        <property type="gene ID" value="B456_012G105000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778802"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGCACVG"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000047">
        <property type="entry name" value="Amino acid transporter AVT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="138"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB76746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="527" mass="57066" checksum="07FD92948E1077F4" modified="2015-04-29" version="1">MKIDEDLGLDREDAFQTDDEENRAERVCCHVEDDTESDFTFPSRNSSNNCIGANNSKWPQSYRKSMDMLKGTTPQSLSFLKRSGATGSMGSSSCNNDESSLGTPLIFDTILDEEVHTPILLTSEQSVSVNGSIPSEKQCSFTQALINGINVLSGIGLLTTPYAVKEGGWLSLTLLIIFGIIACYTGVLLKRCLESSPGLQTYPDIGQAAFGVAGRLMISVILYAELYAACVEYVIMMSDNLSMIFPTTNIHFAEIYLDAPQVFAIIGTLIILPTVWLRDLSLLSYISVGGVGASILMVLCLLWVGVDQVGFHRGGTAVNLANLPISVGIYSFCYAGHSVFPNIYSSMREPSLFPFVLIGSFMFCWTVCTGVAISGFLIFGDSVESQFTLNMPMKFLASKIAVCTVVIITVSKYALTLTPIALSLEELVSSTWFRSYGVSILIRTALVISTLVVAMTVPFFAFVMALAGSLLAMLITIIFPCACYLSILGDRLNKLQITACICIAVLGLVIACLGTYSSIIRIVGRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5W3</accession>
    <name>A0A0D2V5W3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="7">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G158500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5W3"/>
    <dbReference type="Gramene" id="KJB77811">
        <property type="protein sequence ID" value="KJB77811"/>
        <property type="gene ID" value="B456_012G158500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIATECS"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000167">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000169">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB77811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="517" mass="58527" checksum="90F609F0739A9044" modified="2015-04-29" version="1">MDRKVAIIGAGISGLLACKYTLSKGFHPIVFESQSTVGGVWTKTVETTKLQTPKPVYQFSDFPWPESVSEDFPDGQKVFDYVNGYAKHFDLVKHIKFNTKVVGIEFEGPNDEEIQAWSLWGCNGEPFGSKGKWKVVVEDLVTLSTEIYNVDFVIVCVGRFSGLPNIPEFPPKKGPEAFDGKVIHSMEYAAMDHKQAAEFVKGKRVIVVGFQKSALDIAVECSAANGKEDPCTVLYRTAHWNVPDYLPWGFSLAHMYLSRFSELMVHKPGEGLLLSLLATILTPLRYAYSKFVESDIKKKLRLEKHGMVPTHSFLKEISSCLISTVPEKFYDKVENGEIKLKKAPSFSFCNNGVLVEGETSPIEADLVILATGFKGEKKLKHIFMSQTFQDYITGSPDAALPLYRECIQPRIPQLAVIGFSESISNIFTSEMRCRWVAELLDGTFKLPSIKDMEKNIKEWDEYLKQYSGGYYRRKCIGALHIWYNDQLCKDMAWKPRRKKGFFAELFEPYGPMDYVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF79</accession>
    <name>A0A0D2VF79_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G2515001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF79"/>
    <dbReference type="Gramene" id="KJB68575">
        <property type="protein sequence ID" value="KJB68575"/>
        <property type="gene ID" value="B456_010G2515001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB68575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="25" mass="3009" checksum="142C54652DBA3ED2" modified="2015-04-29" version="1" fragment="single">MLDAIIEFEFERVYLHTELGLRGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGI0</accession>
    <name>A0A0D2VGI0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G005700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the terpene synthase family. Tpsa subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGI0"/>
    <dbReference type="STRING" id="29730.A0A0D2VGI0"/>
    <dbReference type="Gramene" id="KJB69110">
        <property type="protein sequence ID" value="KJB69110"/>
        <property type="gene ID" value="B456_011G005700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SHPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIAVMFQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.130:FF:000001">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF93">
        <property type="entry name" value="ALPHA-HUMULENE_(-)-(E)-BETA-CARYOPHYLLENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="6">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="7">
        <location>
            <begin position="253"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB69110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="462" mass="54108" checksum="097D128CC31A80AA" modified="2015-04-29" version="1">MAVQVQGSVSSPMDRPLANYPPDVWGDRFLTLSFDISELESCSRQVEVLKETVKDMLMASTTDPIRNIFLIDSLCRLGVSYHFETEVEQQLAHRFDTLSQLIHNNNYDLHTIAVMFQVFRFHGYNMSSHAFNKFKYENGKFNVSDTKGMISLYEATQFRINGENILDEAFTFTTSHLKSMASQSNPHYAQYIENALYRPYHRGVPRLEARQYICFYEKNEGSNDTLLKFAKYDFNRIQMILQQELSNLRSWWKEGNLESKLPYVRHRIVEFFFYAAGFNFEPRYACARNIQTKLTFIIGIIDDTYDAYGSYEELQHFTDAMRRFDIGVMDKLPTDNFKFVYETILKFHDEAEEKVRKEGRSYGVFYTKNEFKKLAEAYFVEASWAHRSYVPTFDEYMDTALKSSAAIVAVCQAFIGMEEADETAYQWLINTDNKVHKALNIISRLYDDIATNEVYIYILFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MMZ6</accession>
    <name>A0A0D2MMZ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_003G124400</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Probable ATP-dependent zinc metallopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Plastid</location>
            <location evidence="19">Chloroplast thylakoid membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
            <orientation evidence="19">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MMZ6"/>
    <dbReference type="STRING" id="29730.A0A0D2MMZ6"/>
    <dbReference type="MEROPS" id="M41.A04"/>
    <dbReference type="Gramene" id="KJB19912">
        <property type="protein sequence ID" value="KJB19912"/>
        <property type="gene ID" value="B456_003G124400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPRIHGF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000006">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000352">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 7, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF49">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="372"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00060401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB19912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="826" mass="90094" checksum="5E55EB19DA352E67" modified="2015-04-29" version="1">MSSTEFLRPATITFHGKFSTNSYSNLLYLHGLNFKAIRFRVLQQKTNRFFPNSITSTLKNVAVVGNHERLKLYGRGKLRFKESKILANCTDSSDSKASSGEKNESEGGQGVTQKQSPSNSGGSTNQRGEKGGRSGLWRSKGKKWQWQPIVQAQEIGVLLLQLGVVMFVMRLLRPGIPLPGSEPRTPTTFVSVPYSEFLNKINSNQVQKVEVDGVHIMFKLKNEGSVQESEIGKFQESESLLRSMAPTKRIVYTTTRPSDIKTPYEKMLENDVEFGSPDKRSGGFFNSALIALFYVAVLAGLLHRFPVNFSQHTAGQIRNRKARSSGGSKVSEQGETITFADVAGVDEAKEELEEIVEFLRNPDRYIRLGARPPRGVLLVGLPGTGKTLLAKAVAGEAEVPFISCSASEFVELYVGMGASRVRDLFARAKKEAPSIILLMRSAYEHYNFIDAVAKSRDGKFRIVSNDEREQTLNQLLTEMDGFDSNSAVIVLGATNRSDVLDPALRRPGRFDRIVMVETPDRIGREAIIKVHASKKELPLGDDVDLGDIASMTTGFTGADLANLVNEAALLAGRNNKVVVERIDFIQAVERSIAGIEKKTAKLKGCEKAVVARHEAGHAVVGTAVANLLHGQPRVEKLSILPRSGGALGFTYIPPTNEDRYLLFIDELRGRLVTLLGGRAAEEVIYSGRVSTGALDDIRRATDMAYKAVAEYGLNQTIGPLSLATVSGGGMDESGGGVPWGRDQGHLVDLVQGEVKALLQSAHEVALSVVRANPTVLEGLGAHLEENEKVEGEELQKWLKLVVAPKELIIFVEGKQESLLPVQAGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MY86</accession>
    <name>A0A0D2MY86_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_004G144100</name>
        <name evidence="20" type="ORF">Gorai_014776</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="20 22" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
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    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
        </source>
    </reference>
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        <text evidence="13">Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi.</text>
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            <text>GTP + H2O = GDP + phosphate + H(+)</text>
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            <topology evidence="1">Peripheral membrane protein</topology>
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        <subcellularLocation>
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            <location evidence="11">Golgi stack membrane</location>
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        <text evidence="2 18">Belongs to the small GTPase superfamily. SAR1 family.</text>
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    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="8 18" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
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    </evidence>
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    </evidence>
    <sequence length="193" mass="22037" checksum="19259D5576FC67B0" modified="2015-04-29" version="1">MFLVDWFYGVLASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQYPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYDKERFAESKKELDALLSDEALANVPFLILGNKIDIPYAASEDELRYHLGLTNFTTGKGKVNLADSNVRPLEVFMCSIVRKMGYGDGFKWMSQYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N3X3</accession>
    <name>A0A0D2N3X3_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G260500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N3X3"/>
    <dbReference type="STRING" id="29730.A0A0D2N3X3"/>
    <dbReference type="Gramene" id="KJB26792">
        <property type="protein sequence ID" value="KJB26792"/>
        <property type="gene ID" value="B456_004G260500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792697"/>
    <dbReference type="eggNOG" id="ENOG502QQQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGSHCAC"/>
    <dbReference type="OrthoDB" id="1909934at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37254">
        <property type="entry name" value="OS01G0100500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37254:SF1">
        <property type="entry name" value="OS01G0100500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB26792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="606" mass="68092" checksum="5ABAE85FD0162564" modified="2015-04-29" version="1">MASCPQNSILYNGTRCACQVGRFLNVAANSCITYAGNSAIKTDSGIDYYAISIPKNILSFDSIKKFTQSQAVFLEATLVMLLSWLVFCFFLRFMKLGDGRNVWFKIRCWISRLDVCFATRHWLDDQKLVVKRKTELGGTFSIASWILFTGLFAALLYQLIAKRTIEVHNVIATNAPDLASFRNDVEFNMTPVSSMSCSNLRSPTTLLSGSSGFLEDKVLPISDILNVSCHNTSLGPTITLKCSNCRLNQDFMSISWQFVDLPNSPASAVGFQFNVTAKDHIRRDHVSFVSGTLMNGSNFDNSPVTFRGTDTNILIFNLFPRIYRSAKNLRLIQPLFHEFVPGSSLRDTSQLRASLENANDGLINTTLYVNYLSSYIIETENQNIIGAVGFLADLGGLYCISMGIFFYLLVQCEFRIKRLRNEDSILRRIRNRRKAQEHWDKVRKYVMYTWNCSALDVDNHSKAEPGHGCFQLPLGPGNGSVRGGGSSRKRKQLRETELSFHKQVSSEKALKHNTRGSAKAETKHCIGSKDAVAIQHQAFALDDDIIPPPPTLELKSGSEIELSDIQKNFQRLYDYNVMLREKFVATQSLLRDLAAKSPSPTTERQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N7Y3</accession>
    <name>A0A0D2N7Y3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G105300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N7Y3"/>
    <dbReference type="STRING" id="29730.A0A0D2N7Y3"/>
    <dbReference type="Gramene" id="KJB08813">
        <property type="protein sequence ID" value="KJB08813"/>
        <property type="gene ID" value="B456_001G105300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12438">
        <property type="entry name" value="RRM_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000161">
        <property type="entry name" value="RNA binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034261">
        <property type="entry name" value="CNOT4_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF36">
        <property type="entry name" value="RNA BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="110"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1045" mass="113987" checksum="B2411040CDF7BE56" modified="2015-04-29" version="1">MSDEGEKTCPLCAEEMDLTDQQLKPCRCGYEICVWCWHHIMDMAEKDDTEGRCPACRSAYDKERIVGTAAKCERMVAEINMERKMKSHKAKTKSSEGRKQLSSVRVIQRNLVYIVGLPLNLADEDLLQRRDYFGQYGKVLKVSMSRTAAGVIQQFPNNTCSVYITYSKEEEAVRCIQSVHGFVLDGRPLKACFGTTKYCHAWLRNVPCSNPDCLYLHEIGSQEDSFTKDEIISAYTSRVQQITGATNNMQRRPGNMLPPPADDYCPNSSASAAKLITKSSPNNTIVTVPKSSPPNGSSGRSIALPAGASWGMRALNQPQPVSLACTNGPPKQNSDTVSSTLPFSSAVTNTNLACSLHTDVIKKPSEEIHPMHTKGKPDLLKPLKQSAGLDCRIATLEKPTSPERVTVSKSLSNQLSCTAAANHDDQGTNIPSTITSTTFGNGGQTLISSGEKAVIISNTDGDTQRLCSDMSTLTLEGNVLNGHSDEVRPSSSSSEHGCSSSPSNQGLRQSHIDYYREPLNTAAAGSSVTSPNGVCVSKEQSVWKTDARIQAEKNTSSEVEEDVLSFDNQRLKDPEVITRSSYVPNSPISLHLSNHSRSHSLQHNEAFGAVNLNADTLLVDDKAGDNSCLQGANVSSLSNGCLDKYISSSIGSDITIEGPPLLSNEEKGKQLGRILANSQSNDANDTGESNIISNILSLDFDTWDESLTSPQNLAKLLGDNDKQANPLKLSSSWKAPNHNQSRFSFARQEDSKYRLADVESPFNIYGQMPQNHPSGQDFTDNRDSYLSKFGVSNGLYSCNFEESDNFSSSPSVFSNKLSASRAQIPVPPGFSVPSRAPPPGFSSIERVNHAFDATSGNHLMDSQSLLRNSYQAPQSGGISGPGDIEFIDPAILAVGKGRIQGGLNNSGLDMRSNFLQQLGPYENEARFQLLMQRSLSPHQNLRYDVGDSFSSLNDSYGIPSRLMDQSQVNNMSAFAQLNLQQSRNTHNMSNGQWDGWNEVQGGNGLGVAELLRNERLGFNKFYSGYEDSKYRMAASGDLYNRTFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8T6</accession>
    <name>A0A0D2N8T6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G1256002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8T6"/>
    <dbReference type="Gramene" id="KJB09143">
        <property type="protein sequence ID" value="KJB09143"/>
        <property type="gene ID" value="B456_001G1256002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="26" mass="2888" checksum="9E516AEDF521ACC7" modified="2015-04-29" version="1" fragment="single">GQSYTSFDESIGWFLSQTNVQHGLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9D0</accession>
    <name>A0A0D2N9D0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G081000</name>
        <name evidence="13" type="ORF">Gorai_016278</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9D0"/>
    <dbReference type="STRING" id="29730.A0A0D2N9D0"/>
    <dbReference type="Gramene" id="KJB29042">
        <property type="protein sequence ID" value="KJB29042"/>
        <property type="gene ID" value="B456_005G081000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797063"/>
    <dbReference type="eggNOG" id="ENOG502S23U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFIMMDK"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF316">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="11">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="101"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB29042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0585504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="261" mass="29470" checksum="97AD7B0AA4A4E7CF" modified="2015-04-29" version="1">MFILGDQMLQSDPRVPILPIERKWKSNVETAPNCPRCASANTKFCYYNNYSLSQPRYFCKGCRRYWTKGGSLRNVPVGGGCRKSRRGKSRRERVEKRDQISMTDSKNSTSSSDGDSGNQPDIDLALVFAKFLNHNTSFDQPEVDEIATQESPNEENNSQKPVVGSIPGSYILQEMPETSQMEAFGLQNLLTGDEMVLHEDLWSDHDVATTTPDMEWQPLVQLQQYESFPVDEQLKVSANLMNEDWGSFDLSGFGIFSKPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NEM1</accession>
    <name>A0A0D2NEM1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Plant intracellular Ras-group-related LRR protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G178200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Leucine-rich repeat protein that likely mediates protein interactions, possibly in the context of signal transduction.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NEM1"/>
    <dbReference type="STRING" id="29730.A0A0D2NEM1"/>
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        <property type="protein sequence ID" value="KJB31127"/>
        <property type="gene ID" value="B456_005G178200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFPNSIC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055046">
        <property type="term" value="P:microgametogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000405">
        <property type="entry name" value="Plant intracellular Ras-group-related LRR protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF54">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="52323" checksum="5C57AD5C55227837" modified="2015-04-29" version="1">MDPNLSKFPILSYIFSQQDPYNYPSLPPQIRQDLLTRFPHLPDPSILASLSRSIPTSVTQTHSLLRSLGPRPDPSAVSAARSKITHIQETQSSLQEADIYKTVLRLEGLHEDYERQLTEVEENLGRLYCSAVEQMNGDDEVNEDVVRILKEAENGVVERVELSGRQLRLLPEAFGKLHGLVYLNLSNNQIEVIPDSIGGLKKLEELNASSNHLQHLPDSVGLLLNLRILDVSGNKLNALPESIARCSPSFFCSSLVELDASFNNLTFLPNNIGYGLLNLEKLSIQLNKIHFLPSSICEMRSLRYLDAHFNELHGLPQVIGRMTKLEVLNLSSNFNDFTELPDTISDLTNLRELDLSNNQIRALPCTFGRLGKLVKLNLDQNPLIVPPIEIANKGADAVKDYMSKKWLDIITEEQRRINLEASNQQGQMGWLSWGTSLVSNAISGVSQSVGEYLSGPKAPRDPYLDQQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NEZ0</accession>
    <name>A0A0D2NEZ0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G272000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NEZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2NEZ0"/>
    <dbReference type="Gramene" id="KJB11688">
        <property type="protein sequence ID" value="KJB11688"/>
        <property type="gene ID" value="B456_001G272000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769675"/>
    <dbReference type="eggNOG" id="ENOG502QSPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MITEENY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000446">
        <property type="entry name" value="Nodulin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF73">
        <property type="entry name" value="F1C9.29 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="489"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="7">
        <location>
            <begin position="358"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB11688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="591" mass="64524" checksum="4426DB6FA47205E8" modified="2015-04-29" version="1">MMGKLKERIQAFVNNRWLVFVAAIWIQSCAGIGYVFGSLSPVIKRSLNYNQRQLSKLGVAKDLGDSVGFLAGSLSEILPLWGALLVGALQNLIGYGWVWLIVTGRAPVLPLWAMCILIFVGNNGETYFNTAALVSCVQNFPKSRGPVVGILKGFAGLSGAILTQIYTMINFPDQAALIFMVAVGPAMVVVALMFIIRPVGGHRQVRPSDGFSFTFIYSVCLLLAAYLMGVMLLEDLVDVSHTLIIIFTVILFLLLVAPVVIPVKLSFSDEPKDLAVEEVLLPKPEQQEAGKSEQDEVIFSEVEDEKPKEVDLLPATERHKRIAQLQAKLCQAAAEGAVRVKRRRGPHRGEDFTLMQALIKADLWLIFFSLLLASGSGLTVIDNLGQMSQSLGYDNTHIFVSMISIWNFLGRVGGGYFSEIIVRDYAYPRPIAMAVSQLVMAVGHVFFAMGWPGAMYIGTLLIGLGYGAHWAIVPAAASELFGLKKFGALYNFLTLANPAGSLIFSGVIASSIYDREAEKQAHQHHIPPQISGSIFSGMFAVDEPLKCEGSICFFLTSMIMSGFCIIAGVLSLILVYRTKTVYANIYGKSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGX1</accession>
    <name>A0A0D2NGX1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Ubiquinol oxidase</fullName>
            <ecNumber evidence="17">1.10.3.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_005G220400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30255"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="EC" id="1.10.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.11" evidence="17"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGX1"/>
    <dbReference type="STRING" id="29730.A0A0D2NGX1"/>
    <dbReference type="Gramene" id="KJB32047">
        <property type="protein sequence ID" value="KJB32047"/>
        <property type="gene ID" value="B456_005G220400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSB5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106292">
        <property type="term" value="F:superoxide-generating NADPH oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102721">
        <property type="term" value="F:ubiquinol:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000001">
        <property type="entry name" value="Ubiquinol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF6">
        <property type="entry name" value="UBIQUINOL OXIDASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 17" id="KW-0408">Iron</keyword>
    <keyword evidence="16 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="380" mass="43929" checksum="46E749A68FAE94F6" modified="2015-04-29" version="1">MRLTNINYFPFFAPYYITSTLLFDFHKFIIIIKRNEKREKKMNRFIVRSVMQSHLSNGRSISNGHVCSSAIVGRSLELSGQHNVVMLVRFEWRRMMSSTPASVEKASSGREEKMENSVTEETKGKDSSALSYWGISRPKITRADGTDWPWNCFMPWETYSAELSIDLKKRHVPKNFVDKFAFRIVKLLRLPTDIFFQRRYGSRAMMLETVAAVPGMVGGMLLHLKSLRKFQQSGGWIKALLEEAENERMHLMTMVELVKPKWYERLLVLTVQGVFFNAFFVLYMLSPKLAHRIVGYLEEEAIHSYTEYLKDIESGAIENVAAPAIAIDYWRLPKDARLKEVITVIRADEAHHRDVNHFASQDIHFAGKELKDAPAPLGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NI30</accession>
    <name>A0A0D2NI30_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_002G042600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NI30"/>
    <dbReference type="STRING" id="29730.A0A0D2NI30"/>
    <dbReference type="Gramene" id="KJB12883">
        <property type="protein sequence ID" value="KJB12883"/>
        <property type="gene ID" value="B456_002G042600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTKNFND"/>
    <dbReference type="OrthoDB" id="544400at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000590">
        <property type="entry name" value="PR5-like receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="30"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="315"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="38534" checksum="F7681676C729D5B2" modified="2015-04-29" version="1">MDGMIEEFLQSQNNFVPIRYSYREIKKMTKNFNDKLGEGDYGSVFKGKLRSGHHVAIKLLGKSKGNGQDFINEVASIGRIHHANVAKLIGFCVEGSKQALVYDFMPNGSLDKIIFTEENKNTLSWKKMFDIVLGVAQGIHYLHQGCDMQILHFDIKPHNILLDEHFNPKVSDFGLAKLYSVDDSIVSLTAARGTIGYIAPELVYKNLGGISYKADVYSFGMLLMEMVGRRKNVNAFADHTSQIYFPSWIYDRLDQGEDIELGDVSDDEKVMVKKMIITAFWCIQLLPSDRPSMNKVLKMLESNVELLEMPPKPFHQLPLDENSNDEPSTPLDSVTIASSNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NI51</accession>
    <name>A0A0D2NI51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alkaline/neutral invertase</fullName>
            <ecNumber evidence="6">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G252100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Invertase that cleaves sucrose into glucose and fructose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.</text>
            <dbReference type="EC" id="3.2.1.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 100 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="6"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NI51"/>
    <dbReference type="Gramene" id="KJB32627">
        <property type="protein sequence ID" value="KJB32627"/>
        <property type="gene ID" value="B456_005G252100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32628">
        <property type="protein sequence ID" value="KJB32628"/>
        <property type="gene ID" value="B456_005G252100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795385"/>
    <dbReference type="eggNOG" id="ENOG502QPS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSQNGNI"/>
    <dbReference type="OrthoDB" id="585877at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033926">
        <property type="term" value="F:endo-alpha-N-acetylgalactosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000001">
        <property type="entry name" value="probable alkaline/neutral invertase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024746">
        <property type="entry name" value="Glyco_hydro_100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31916">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31916:SF40">
        <property type="entry name" value="ALKALINE_NEUTRAL INVERTASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12899">
        <property type="entry name" value="Glyco_hydro_100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="577" mass="66281" checksum="32FB5252FB6027AB" modified="2015-04-29" version="1">MSTPDVDVNQNQNQNKNVKAEDILCPLAEYEECDFSKLLEKPRLLNIDRQRSLDERSLSELSIGISPRHATRAIDPNSYRFFEQLDSICSPVGRRSGFSTPRSQIGFDPHPMVAEAWEALRRSLVYFRGQPVGTIAALDNTEENLNYDQVFVRDFVPSALAFLMNGEPEIVKNFILKTLRLQSWEKKIDRFQLGEGVMPASFKVLHDPVRNNETLIADFGESAIGRVAPVDSGFWWIILLRAYTKSTGDTSLAELPECQKGMRLILSLCLSEGFDTFPTLLCADGCCMIDRRMGVYGYPIEIQALFFMALRCALLLLKQDDEGKEFIERIVKRLHALSYHMRSYFWLDLKQLNDIYRFKTEEYSHTAVNKFNVMPDSLPEWVFDFMPVYGGYFIGNVSPARMDFRWFCLGNCIAILSSLATPEQSTAIMDLIESRWEELVGEMPLKVCYPAMETHEWRIITGCDPKNTRWSYHNGGSWPVLLWLLTAACVKTGRPQIARRAIEIAEARLLKDHWPEYYDGKLGRYIGKQSRKAQTWSIAGYLVAKMMLEDPSHLGMIAIEEDKQMKPILRRSYSWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJR5</accession>
    <name>A0A0D2NJR5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G006500</name>
        <name evidence="3" type="ORF">Gorai_000079</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0586939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJR5"/>
    <dbReference type="STRING" id="29730.A0A0D2NJR5"/>
    <dbReference type="Gramene" id="KJB33322">
        <property type="protein sequence ID" value="KJB33322"/>
        <property type="gene ID" value="B456_006G006500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798066"/>
    <dbReference type="eggNOG" id="KOG1685">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PQRAYKN"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000012">
        <property type="entry name" value="Ribosomal protein L1p/L10e family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="39825" checksum="ADEA6280D48D3B65" modified="2015-04-29" version="1">MAKNMGVAVAAALSELNVEKAVNALLKWRDSQSQAQKPQLLEQDEFLYLIVSLKKIPQKARVNPIKVPLPHPIIDDPAELCLFIDDRSKSGITKDAASKKIKSENIPINKVIKLSKLKTDYKPFEAKRKLCDSYDMFFADKRIIPLLPRLLGKQFFKKKKIPVPVDLKHNNWKEQIHNACSSAMLFLGSGTCCVVKVAKLSLEKKEIVENVIAAINGIAERVPSKWGNIRSFHLKLLDSLALPLFQAMPDLRLKILADADHHTSSKEEKQEVEEEEDDTSHQKTKKKKNKGRIHDVQYMDDREHINDSNSEADGKHEINANISTKKKKTALKKLCSIDIKVKDKKKKKSLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKF7</accession>
    <name>A0A0D2NKF7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G014700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <location evidence="1">Nucleus</location>
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        <property type="gene ID" value="B456_006G014700"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of flower development"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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        <property type="entry name" value="KH domain-containing protein"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
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        <location>
            <begin position="137"/>
            <end position="211"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="365"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="565" mass="62100" checksum="746821F884539FD2" modified="2015-04-29" version="1">MAGQRNSYGKRSHSQSDYSENGSNKRRNAGDDREQFVIDSDDTVYRYLCPARKIGSIIGRGGEIVKQLRADTKSKIRIGETIPGSDERVVTIYSSRDERNALEDGDSFVSPAQDALFRVHDRVVAEDLHSDEDSEGRQITARLLISSDQIGCVIGKGGQIVQNIRSETGAQIRILKDDLPSCALSTDELVQISGEAAVVKKALHQIASRLHENPSRSQHLLASAVSNAYPAAGAMLGPAAGARIVGVTSLVGPYGRYKGDTGEWPRSMYSAPRDEMSSKEFSLRLVCPTANIGGVIGKGGAIINQIRQESGAAIKVDSSTTDGDDCLITISAKEFFEDWYSPSIEAAARLQPRCSEKVEGDSGIVSFTTRLFVPTSRIGCLIGKGGAIVTEMRRITKANIRILSKENLPKIASEDDEMVQIAGDLDVAKDALVQITTRLRANLFDREGAVNALVPVLPYLHVPTEGTDNLSYESREGKRHGRVHSFSGGYGSSDLSSSDSYGSYGGLQYYWCSWSLFCRTWWSFWVIKPYLCFPALKLWLLKFRYWYLRLMKPESSLLPTLMKPA</sequence>
</entry>
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    <accession>A0A0D2NLU3</accession>
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        <name type="scientific">Gossypium raimondii</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_002G119800"/>
    </dbReference>
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        <property type="entry name" value="ADENINE NUCLEOTIDE ALPHA HYDROLASES-LIKE SUPERFAMILY PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31964:SF122">
        <property type="entry name" value="OS02G0760500 PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="70" mass="8054" checksum="99F24BB393D2FE2E" modified="2015-04-29" version="1">MNYEFGIFLTQANVKTQVVIGDPKEKICEVIENVHADLLVMGSRAFGPIKRYFPHCNVTFLESRLVELFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NNG6</accession>
    <name>A0A0D2NNG6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G080200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NNG6"/>
    <dbReference type="STRING" id="29730.A0A0D2NNG6"/>
    <dbReference type="Gramene" id="KJB34707">
        <property type="protein sequence ID" value="KJB34707"/>
        <property type="gene ID" value="B456_006G080200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S30Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAFIITI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34188">
        <property type="entry name" value="OS01G0299500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34188:SF20">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="239" mass="25987" checksum="4EC51BF291E55C8F" modified="2015-04-29" version="1">MATREKNTELDLEKGLTISEEEDQIKNPFSSLKNKAQMLLSKFSFSDNVSSDERVSLSGDASDSGSTEAVNKEGQDNKGVIGKESNNDNKINNNNKVGKEKRNKKAPKPPRPPKAPTLDAADRRLIKELAELARLKRARIERMKAMEKMKATKGISSNTTILAMVLIIILLIVIIYHGMESRGTSTKSGGSEMGVGGVLSLELFGDPSSSISNTGSPLYVLLVIAISICCSCFLKWVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NSZ6</accession>
    <name>A0A0D2NSZ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_002G257100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NSZ6"/>
    <dbReference type="STRING" id="29730.A0A0D2NSZ6"/>
    <dbReference type="Gramene" id="KJB16963">
        <property type="protein sequence ID" value="KJB16963"/>
        <property type="gene ID" value="B456_002G257100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786494"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMAARPY"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF493">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113157" description="Laccase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="162"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="424"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB16963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="573" mass="63842" checksum="49D1C3314074E0D4" modified="2015-04-29" version="1">MAETSHLSSMAMLFISFFVVLMGNAEGETRHYTFNIRYHNVTRLCHTRTILSVNRRYPGPPLVAREGDRVIVKVVNHVANNVSIHWHGIRQLTTGWSDGPSYVTQCPIQTNQSYIYNFTITGQRGTLLWHAHISWLRATIHGPIIILPKLNQSYPFQKPHKEVTIILGEWFNEDPEAIISQALRTGGGPNVSDAYTINGLPGLLYNCSSKDTYKLKVKPGKTYLLRLINAALNDELFFTIANHTLTVVEGDAIYTKPFDTDKLLITPGQTTNVLLKTKPEYPNATFLIAARPYSTGQGTFDNSTTMGVLEYEHPFKKPSKNPTLIQPNLPQINDTQFVSNFTMKFRSLANDEFPANVPKTVDKRFFFTVGLGTSPCPKNTTCQGPTNSTKFAASVNNVSFTLPSVAILQAYYFGQSNGVYTTDFPVEPMVRFNYTGIAPNNTNVMNGTRTVVLPFNTSVELVMQDTSILGAESHPLHLHGFNFFVVGQGFGNFDPVKDPAKFNLVDPMERNTAGVPAGGWIAIRFLADNPGVWFMHCHLDVHTSWGLKMAWLVLDGPEPNQKLQPPPSDLPQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1A3</accession>
    <name>A0A0D2P1A3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G014900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P1A3"/>
    <dbReference type="STRING" id="29730.A0A0D2P1A3"/>
    <dbReference type="Gramene" id="KJB39467">
        <property type="protein sequence ID" value="KJB39467"/>
        <property type="gene ID" value="B456_007G014900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2887">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISCCDTE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF29">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB39467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="178" mass="20102" checksum="2BB9FDFFD49F24A5" modified="2015-04-29" version="1">MWKMGNDEEDRAESFLDEDSEGICSLSTTQRIYASAACLLSGLVLMFLSLIVFAIPIKFALLFTFGNVLAVGSTAFLMGPEQQLRMMFDSVRVYATVIYIGFVVLALICALWCFTVSELSGLTFHFLKLVIWQIQSKILTLLAIICEICALIWYCLSYIPFARRIVSDLMVRFCDTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1E6</accession>
    <name>A0A0D2P1E6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G144600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P1E6"/>
    <dbReference type="STRING" id="29730.A0A0D2P1E6"/>
    <dbReference type="Gramene" id="KJB20358">
        <property type="protein sequence ID" value="KJB20358"/>
        <property type="gene ID" value="B456_003G144600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788978"/>
    <dbReference type="eggNOG" id="KOG2468">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWLAYHC"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB20358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="567" mass="63251" checksum="B74F3CF3FF8D9845" modified="2015-04-29" version="1">MAISPSKAMNGERAVVLIFVLRVLFSLPLALLPHALSLSLLSLFSLVVEIRVDDSPSLFKTRPGASSGIILGAVTLPTVMLSKLIQLSRAVSLQQIEIGELEHMTMQFWAASACSCGVLIFLFIVTWCAANNKNPHFSCSVWDAKFSLSCVILYSAVCCISLATISHTGFNTALKLLWLLCHGFATVKLIQHLLSTFPFCASIGEANLVTSGLVLYFGDMLACTISKVCRLLIPPELVSIRYGIKRSEIGIVIQGVLLGLLIFSAVFKFLIHLWEYFWGANNSESRERKEIWRSLIFLTSLGFIMIAVAPSWMMIVLDFDVHPVLWIFQFIFSEPFKRLSLCIYWLVLIYASVLRFYHISKNSKIERILLRKYYHLLAVLMFLPALIYQPKFLDLAFSAALAVFLVLEIIRVWRIWPLGQLVHQFMSAFTDHRDSDLIIVSHFSLLLGCALPIWMSSGFNDRPLTPFSGILSLGIGDTMASMVGHKYGVLRWSKTGKKTIEGTAAGITSVLAACSVLLPLLASTGYFLTQHWFPIFIAVTTSGLLEAYTTQLDNAFIPLVFYSLLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P3B2</accession>
    <name>A0A0D2P3B2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G180400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">The glycine decarboxylase (GDC) or glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="9">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB21048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P3B2"/>
    <dbReference type="STRING" id="29730.A0A0D2P3B2"/>
    <dbReference type="Gramene" id="KJB21048">
        <property type="protein sequence ID" value="KJB21048"/>
        <property type="gene ID" value="B456_003G180400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789337"/>
    <dbReference type="eggNOG" id="KOG3373">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EKISCKR"/>
    <dbReference type="OrthoDB" id="10264154at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000011">
        <property type="entry name" value="Glycine cleavage system H protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002270">
        <property type="entry name" value="PRK01202.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715:SF27">
        <property type="entry name" value="GLYCINE CLEAVAGE SYSTEM H PROTEIN 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="56"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="8">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB21048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="165" mass="17591" checksum="5BAAFB5DF7DCEC70" modified="2015-04-29" version="1">MALRMWASSTANALKISCSSKPNVSLAFSLSRCFSTVLDGLKYANSHEWVKHEGPVATIGITDHAQDHLGEVVFVELPEPGGSVSQGKGFGAVESVKATSDINSPISGEVVEVNSKLSETPGLINSSPYADGWMIKVKPSSPSELESLMGSKEYTKFCEEEDASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P5N7</accession>
    <name>A0A0D2P5N7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CCR4-Not complex component Not1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G0881001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2P5N7"/>
    <dbReference type="Gramene" id="KJB41042">
        <property type="protein sequence ID" value="KJB41042"/>
        <property type="gene ID" value="B456_007G0881001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41043">
        <property type="protein sequence ID" value="KJB41043"/>
        <property type="gene ID" value="B456_007G0881001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41045">
        <property type="protein sequence ID" value="KJB41045"/>
        <property type="gene ID" value="B456_007G0881001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000002">
        <property type="entry name" value="Transcription regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000003">
        <property type="entry name" value="Transcription regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="27"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="343"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="690"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="1411"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="209"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="879"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1213"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="884"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB41042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1795" mass="197242" checksum="8E88E5952AB5C2D6" modified="2015-04-29" version="1" fragment="single">VLKANTGVIASTQLLEEMERLHVTIMDSTQKLQNGGTTESSTSDGYGDDIEAEANSYFHQMFSEQLTTDAMVQMLARFKDSSVRREQLIFECMIANLFEEYRFFPKYPERQLKIAAVLFGSVIKHQLVTHLTLGIALRCVLDALRKPADSKMFLFGTKALEQFVDRLIEWPQYCNHILQISHLRATHSELVAFIERALVRISSGHLESDGSNNLSAHHQASSQVTPVNGELNSSGIAQPGPQLSSQLQLPRHDSSHDDRIKAPAASSNDVKPLVSSVGQPSVAPLSDASSIQKVSQSVGSGSSMLSASPGFVRSSRGVTSTRFGSALNIETLVAAAERRETPIEAPASEIQDKISFIINNISVANIEAKGKEFTEILKEQYYPWFAQYMVMKRASIEPNFHDLYLKFLDKVNSKALTKEIVQATYENCKVLLGSELIKSSSEERSLLKNLGSWLGKLTIGRNQVLRAREIDPKSLIIEAYEKGLMIAVIPFTSKILEPCQSSLAYQPPNPWTMGILSLLAEIYSMPNLKMNLKFDIEVLFKNLGVDMKDISPTSLLKDRKRELEGNPDFSNKDVGVSQAPMVAEVKSGIISPLNHVDLSLEGASPPNSGGPTHLLSQYAGPLRLSSGALMEDEKLAALGLSDQLPSAQGLFQATPSQSPFSVSQLSTSIPNIGTHVIINQKLSSLGLHMHFQRVVPIAMDRAIKEIVAGIIQRSVSIATQTTKELVLKDYAMESDETRIYNAAHLMVASLAGSLAHVTCKEPLRGSISSQLRNSLQGLSVGSDLLEQAVQLVTNDNLDLGCAVIEQAATDKAIQTIDGEIATQLSLRRKHRDPTFFDPSMYGQGSVGVVPEALRPKPGHLSLSQQRVYEDFVRLPWQNQSGQNSHSMSASPSSLSGDAGLTGTFGSTSGQGTPGYTSGPGTLGQLDVTSEAIETSSAALLSASSIHIGAGAALTQQTTENDPLNASFPSTTLAPELHSVDTTDAVKELGPTPQPLPSSAVTERLGSSISEASLSTRDALDKFQLVALKLESLVTTDGREADIQGLISEVPEIILRCVSRDEAALAVAQKVFKGLYENASNSLHVNAYLAILAAVRDVCKLAVKELTSWVIYSDEERKFNKDITVGLIRSELLNLAEYNVLMAKLIDGGRNKAATEFAMSLLQTLVTDESRVISELHNLVDALAKVASKPGSSESLQHLIEMIGNPSASMAVLSSASIGKEDKTRQSRDKKAPGHTPASREDNSNIEALEPDPAGFKEQVSMLFAEWYQICELPGANDGPCNHYIVQLHQNGLLKGDDTTERFFRIIMELSVAHCLSSEVMNSGTLQSPQQVQTLSFLAIDIYAKLVVSILKFCPVEQGSSKLFLMSKILTVTVRLIQKEAEDRKAAFNPRPYFRLFINWLLDLGSLDPVPDGANFQILTAFANAFHALHPLKVPAFSFAWLELVSHRSFMPKLLTWNGQKGWPYIQRLLVDLLQFLEPFLRNAELGVPVHFLYKGTLRVLLVLLHDFPEFLCDCHFTFCDVIPPSCIQMRNIILSAFPRNMRLPDPSTPNLKIDLLPEIREPPRILSEVDAALKAKQMKADVDEYLKMRPQGGSTFLTELKQRLLLSPSEAASAGTRYNVPLINSLVLYVGMQAIQQLQSRVPHAQSAASTAPMSVFLVSAALDIFQTLIADLDTEGRYLFLNAIANQLRYPNNHTHYFSFILLYLFAEANQEIIQEQITRVLLERLIVNKPHPWGLLITFIELIKNPRYNFWNRSFIRCAPEIEKLFESVARSCGGLKPVDDSIVSGWVSDNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PC11</accession>
    <name>A0A0D2PC11_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G195000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PC11"/>
    <dbReference type="STRING" id="29730.A0A0D2PC11"/>
    <dbReference type="Gramene" id="KJB43337">
        <property type="protein sequence ID" value="KJB43337"/>
        <property type="gene ID" value="B456_007G195000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803718"/>
    <dbReference type="eggNOG" id="ENOG502QR7K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSTIQVI"/>
    <dbReference type="OrthoDB" id="162989at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47512:SF3">
        <property type="entry name" value="CHALCONE-FLAVONONE ISOMERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47512">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="301" mass="32873" checksum="7C65FE16BB7AA271" modified="2015-04-29" version="1">METLAASNNGIPVSKVKTEGSEKSASKTRTRNGKQQQQEEERSALIDITNDSPIVGVAMKTPSSAVVGKGKTNMMTMMTSGSGEALLRGQVKTLLQKVEEEAEVSKVPLESRPFVHLQSPMALLAPTPANTPQVPNLSEDGGLASMLMDLPVVEEELNISEMVSANIEGQKCVITRSLLLDFAEKSECRSDNGVIITDSSASNEKTSAFHNDDIDSASIWSIQLNASTQDEYEDKETFEEMGAEYYDHEEDGGLVDDLCKCISKISMTEMFTGKHTRFIYDSDDKIGEEESGENWSTIQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PE14</accession>
    <name>A0A0D2PE14_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G181600</name>
        <name evidence="6" type="ORF">Gorai_015053</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PE14"/>
    <dbReference type="STRING" id="29730.A0A0D2PE14"/>
    <dbReference type="Gramene" id="KJB25218">
        <property type="protein sequence ID" value="KJB25218"/>
        <property type="gene ID" value="B456_004G181600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHCALLR"/>
    <dbReference type="OrthoDB" id="736572at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000196">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At4g14850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000184">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000576">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="DYW_dom"/>
    </dbReference>
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        <property type="entry name" value="E_motif"/>
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    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF400">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="165"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="298"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="513"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB25218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0584230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="605" mass="68698" checksum="C1D1B3A778B2B7FC" modified="2015-04-29" version="1">MAGTSVLQQTNFFSPPADPPQFSELNLRLKEQQCLSLLKRCKNLEDFKQAHAQIIKWGFFWNSFSASNLVAACALSDWGSLDYACSIFQQFHEPGTFEFNTMIRAHVKDMNFQDALVFYYEMLERGVEPDNFTYPALFKACAWLKAREEGMQIHGHVFKFGFESDLYVQNSLINMYGKCGEIQHSCAVFEQMDEKSVASWSAIIAANASLGMWYECLMVFGNMSSEGCWRPEESTLVTLLSACTHLGALDLGKCTHGALLRNISELNVIVQTSLIDMYVKCGYLEKGLSLFKKMTKRNQMSYTVMISGLAMQGHGEEALGIYSMMLEEGLDPDDVVYVGVLSSCSHAGLVDEGFNCFDRMKSEHGIEPTAQHYGCMVDLMGKAGMINEALEFINSMPIKPNDVVWRSLLSACRVHCNLEIGEIAAKHLFESNSQNAGDYVILSNMYARAEKWVEVAKIRTEMARKGFNQVPGFSLVEVGRRIHKFVSQDTSHPRCGNVYEMIHQMEWQLKFEGYSPDTSQVLLDVDEEEKRQRLKGHSQKLAIAFALIHTSKGTPIRIARNLRMCSDCHTYTKLISIIYEREITVRDRNQFHHFKNGTCSCRDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PFJ1</accession>
    <name>A0A0D2PFJ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G205900</name>
        <name evidence="12" type="ORF">Gorai_015224</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PFJ1"/>
    <dbReference type="STRING" id="29730.A0A0D2PFJ1"/>
    <dbReference type="Gramene" id="KJB25723">
        <property type="protein sequence ID" value="KJB25723"/>
        <property type="gene ID" value="B456_004G205900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792153"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGMRILH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009813">
        <property type="term" value="P:flavonoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046148">
        <property type="term" value="P:pigment biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000009">
        <property type="entry name" value="Flavonol synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0284">Flavonoid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="206"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB25723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0584409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="354" mass="40298" checksum="1A7FA5BCA8536DB6" modified="2015-04-29" version="1">MVTSVLPRVESLASSGIQSIPKEYIRPQEELTSIGNVFEEEKKEEGPQVPTIDLTEIESEDKEVRERCRQELKNAAMEWGVMHLVNHGISEELMDRVRKVGQKFFELPVEEKEKYANDQSSGNVQGYGSKLANNASGQLEWEDYFFHLIFPEDKRDLSIWPKIPSEYTEVTSEYARQLRGLASKILSALSICLGLEEGRLEKEVGGLEELLLQLKINYYPKCPQPELALGVEAHTDISALTFILHNMVPGLQLFYQGKWVTAKCVPNSIIMHIGDTIEILSNGKFKSILHRGLVNKEKVRISWAVFCEPPKDKIILKPLPETVSETDPPLFPPRTFAQHIEHKLFRKTQDNLSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PFT7</accession>
    <name>A0A0D2PFT7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribulose bisphosphate carboxylase large chain</fullName>
            <ecNumber evidence="3">4.1.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G279500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 (2R)-3-phosphoglycerate + 2 H(+) = D-ribulose 1,5-bisphosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="4.1.1.39"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>D-ribulose 1,5-bisphosphate + O2 = 2-phosphoglycolate + (2R)-3-phosphoglycerate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36631"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57870"/>
            <dbReference type="ChEBI" id="CHEBI:58033"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuBisCO large chain family. Type I subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PFT7"/>
    <dbReference type="STRING" id="29730.A0A0D2PFT7"/>
    <dbReference type="Gramene" id="KJB44917">
        <property type="protein sequence ID" value="KJB44917"/>
        <property type="gene ID" value="B456_007G279500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SANPYCL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016984">
        <property type="term" value="F:ribulose-bisphosphate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019253">
        <property type="term" value="P:reductive pentose-phosphate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.150">
        <property type="entry name" value="RuBisCO large subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033966">
        <property type="entry name" value="RuBisCO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017443">
        <property type="entry name" value="RuBisCO_lsu_fd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036422">
        <property type="entry name" value="RuBisCO_lsu_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42704:SF15">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02788">
        <property type="entry name" value="RuBisCO_large_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54966">
        <property type="entry name" value="RuBisCO, large subunit, small (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0113">Calvin cycle</keyword>
    <keyword evidence="13" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribulose bisphosphate carboxylase large subunit ferrodoxin-like N-terminal" evidence="16">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB44917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="152" mass="17086" checksum="6D19B221EBD431BE" modified="2015-04-29" version="1">MSCREGLMSPQTETKASVGFKAGVKEYKLTYYTPEYAVKDTDILEAFRVTPQPGVSPEEAGVTVAVESSTGTWTTVWTDGLTSLDRYKGRCYHIEPVPREEDQYICYVAYPLDLFEEGFGLLTCLLPLWVMYWVQSPACSTCRGSANPYCLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PIQ5</accession>
    <name>A0A0D2PIQ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G337700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PIQ5"/>
    <dbReference type="STRING" id="29730.A0A0D2PIQ5"/>
    <dbReference type="Gramene" id="KJB45917">
        <property type="protein sequence ID" value="KJB45917"/>
        <property type="gene ID" value="B456_007G337700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801643"/>
    <dbReference type="eggNOG" id="ENOG502RXRA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVPGPNI"/>
    <dbReference type="OrthoDB" id="935488at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008190627" description="Dirigent protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB45917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="194" mass="21584" checksum="954A34218173ED96" modified="2015-04-29" version="1">MKNRMIFAWAMIFCLAVAPIYGQYYSKTIKAGPRVEKMTRLRFFYHDIPVGKDPTTFLIAQANITRKFFSPSPYGSLYSMDDPLTLGPNRTSKMVGNAQGLYLALSRDPTKFSAVFYADFAFTTGKFKGSSFSLFSRYPLTDFVPGPNIIREMAIVGGTGAFRMAKGFALFRASSSSAKTGDASLKVDVTLYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PKR0</accession>
    <name>A0A0D2PKR0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4408 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G022700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PKR0"/>
    <dbReference type="STRING" id="29730.A0A0D2PKR0"/>
    <dbReference type="Gramene" id="KJB07424">
        <property type="protein sequence ID" value="KJB07424"/>
        <property type="gene ID" value="B456_001G022700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RYM2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQKPHEI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025520">
        <property type="entry name" value="DUF4408"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098:SF53">
        <property type="entry name" value="OS05G0540900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14364">
        <property type="entry name" value="DUF4408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4408" evidence="3">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB07424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="296" mass="33184" checksum="9C6DFFF6F1E0AAF8" modified="2015-04-29" version="1">MLEESMSTVPSSSLWASIFSWFTPTVFFVFLNITIGTIFFTSTFSSNNSGAAASGGVGDGPSLHEGDETNDPRLLPSPSVLQRLKSINLYSYRSQQPFTTTTAAAEIPDSGADFHISFQQQTSETETTPEPVPTHLDRSPSVLHRLKSINLYGYFSPGQKPREISSHYTPEEEEIKEPEQVEQTQGEERGFDEIYSELNRNNQVTRTKSDAEPASGEVPTKLPKKMKKSASAKSPFSHFEEDDILEARRPATMREGKGKATEEDDEVDAKADDFINKFKEQLKLQRMDSRLGTRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PQC4</accession>
    <name>A0A0D2PQC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G072100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PQC4"/>
    <dbReference type="STRING" id="29730.A0A0D2PQC4"/>
    <dbReference type="Gramene" id="KJB48497">
        <property type="protein sequence ID" value="KJB48497"/>
        <property type="gene ID" value="B456_008G072100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009532">
        <property type="term" value="C:plastid stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF12">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB48497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="145" mass="16524" checksum="CE8D47B69A3A769E" modified="2015-04-29" version="1">MFLGYHVIKTRTDTHKKKVRNLEERHANLVMDLDQMQWVAWKRLLAFENMGAFLLSAGTKGKQYSLPNSRVMIHQPLGGAEGGQIDIDIQANEMLHHKADLNLNIFLTHAALLLNSACFVFFFVFPITAAVVMQREWGLPIIMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRX1</accession>
    <name>A0A0D2PRX1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G151500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRX1"/>
    <dbReference type="STRING" id="29730.A0A0D2PRX1"/>
    <dbReference type="Gramene" id="KJB09594">
        <property type="protein sequence ID" value="KJB09594"/>
        <property type="gene ID" value="B456_001G151500"/>
    </dbReference>
    <dbReference type="OMA" id="LAFKIMP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="1">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB09594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16603" checksum="FC0CDDBF39BDCFC9" modified="2015-04-29" version="1">MIILVFLVFQNSKTLPLPTLSLAFTFSSFFCTLTPESFTKMAQNDGGSSGGSNPVDNLASRPKRKRITIHIQSQDENRLAFKIMPNLKLSKMFHEYCQRKQYDLRTVRFFHEGRRLLGKYTAAKVPFFASFPCSPICYKDFFCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTD8</accession>
    <name>A0A0D2PTD8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G183300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2PTD8"/>
    <dbReference type="Gramene" id="KJB10079">
        <property type="protein sequence ID" value="KJB10079"/>
        <property type="gene ID" value="B456_001G183300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798699"/>
    <dbReference type="eggNOG" id="KOG2956">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000580">
        <property type="entry name" value="Protein peg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="3"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="83"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="282"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="779"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="7">
        <location>
            <begin position="1194"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1432" mass="158590" checksum="E6B1B9FD11BF16ED" modified="2015-04-29" version="1">MEEALELARAKDTKERMAAVERLYHLLEGSRKSLTYSEVTSLVDCCMDLLNDNNFRVSQGALQALASAAVLSGDHLKLHFNALVPAVVERLGDAKQPVRDAARRLLLTLMEVSSPTIIVERAGSYGWTHRSWRVREEFAQTVTSAISLFASTELPLQRAILPPILQMLHDSNPGVREAAILCIEEMYMQAGTQFRDELHRHQLPASMVRDINARLEKTEMLVRPSNGTLGGLAAGDRKPVIYNVKKSSPRAKSSSRETYLLGGEIDVTEKSTDPIKVYSDKELIREFEKIASTLMPEKDWSIRIAAMQRVEGLVSGGAADYPCFRGLLKQLVGPLSTQLSDRRSSIVKQACHLLCFLSKEFFGEFESCAEMFIPVLFKLVVITVLVIAESADNCIKMMLHNCKVARVLPRIADCAKNDRNAVLRARCCEYALLILEHWPDAPEIQRSADLYEDLIRCCVADAISEVRSTARMCYRMFTKTWPDRSRRLFSSFDPAIQRIINEEDGGMHRRHASPSLRDRNVKISFTSQTSATLNVPGCGTSAIVAMDRTSSLSSGTSLSSGLNFSQSKPVGKGAERTLESVLHASKQKVSAIESMLRGLDISEKQRSTSLALGVDPPSFRDPPFPAAVSASNSLTSSLGLESITSTVGKSGNHNGDLILSDIITQTSKDSGKLSYRSNVATESFPVLSSYSPRRAAVRPDRGSIEDNTDIREASRFIKPHIDRQYFEMPYRDVNSRHSQNNNIPNFQRPLSRKHVSGRISAERRKIFDDNQPSLGEISNYVDGPASLTEALSEGLSPSSNWCARVAAFMYLQSLLQQGPKGVLEVNQNFMKVMKLFFQHLDDPHHKVAQAALSTLADIIPSCRKPFESYMERILPHVFSRLIDPKESVRQPCSTTLGIVSKTYSIDSLLPALLRSLDEQRSPKAKLAVIEFSISSFNKHATNSEGSSNIGILMLWLAKLKPLVHDKNTKLKDAAISCIISVYSHFDAIAVLNFILSLSVEEQNSLRRALKQYTPRIEVDLISYLQNKKERQRSKSSYDPYDAVGTWSEEGYVGVSKKSLLLGRYSSGSVDSEGGRKGSTQDSTLITGPIGQETSDETQVNLFQNFGISSNADVLPSKTKELSYMVNSNDQNLGSQMGQVENLESSVNMEGLSTPHLETNGPSRFDSLVDVKGVACDHDISSELDLNHLKPAPVKIGSMPDTGPSIPKILHLFCNGIDESSTASKRGALQQLIEISVANDISIWTKYFNQILTTLLEVLDDSDSSIRELALSLIVQMLKNQKDAMEDSVEIVIEKLLHVTKDIVPKVSNEAENCLNTVMSQYDPFRCLSVIVPLLVTEDEKTLVICINCLTKLVGQLSQEDLMSLLPSFLPAIFEAFGNQSADVRKTVVFCLVDIYIMLGKAFLPHLEGLNSTQLRLVTIYANRISQARLGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUP5</accession>
    <name>A0A0D2PUP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G140900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUP5"/>
    <dbReference type="STRING" id="29730.A0A0D2PUP5"/>
    <dbReference type="Gramene" id="KJB49847">
        <property type="protein sequence ID" value="KJB49847"/>
        <property type="gene ID" value="B456_008G140900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764074"/>
    <dbReference type="eggNOG" id="KOG0825">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEMPKAT"/>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17711">
        <property type="entry name" value="BRCT_PAXIP1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17738">
        <property type="entry name" value="BRCT_TopBP1_rpt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044254">
        <property type="entry name" value="At4g02110-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47181">
        <property type="entry name" value="BRCA1 C TERMINUS DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47181:SF2">
        <property type="entry name" value="BRCA1 C TERMINUS DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="109"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="7">
        <location>
            <begin position="936"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="1194"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="488"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="565"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="739"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="784"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="848"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB49847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1264" mass="138223" checksum="C9AD8426CD98BA51" modified="2015-04-29" version="1">MLESDTPSKTFLGVRFCLYGFDPVNEHNVRVKLINGGGVGVGQYSQSCTHVIVDKIVYDDPVCVAARNDGKTVVTGLWVDHSFDIGMPVDATSIMYRPLRDLNGIPGAKSLIICLTGYQRQDRDDIMTMVGLMGAQFSKPLVASKVTHLICYKFEGEKYELAKKIKKIKLINHRWLEDCLRDWELLSEANYSKSGYELEVMEAEAKDSDEEAEETTLKHSGQGSLNRSPHSLKAGMTSSGELLSTVEVSTSTVPRHSPNTKEVLVMPGKSHLGTSFDDVNDPELNSFQNSGLKNGSSIKLAQPGNRGSNTTNMDSNLASTSKSPSLSNDLFTAISYSRKTPRNATPPNLSGEVSGNISGSPQAMKIQDVSGISSSKIQQPEKRICASFVRSPRKGSDLCHGEDSAGILPQKRALELSGSSSKSRKMSYNAKGSIKGSALDTVQLEPTSSVGDQLQINDYPVNETGYPNVLHSSCAGYVTTKLSTDLFSSKSVTPDDRQNVRDEKSPNMSPRGYRGSTLAGKLDMQNENAYEKSPQMSFKGLRESTSASRSNIGDYGLERLQVVGEPGELQNKQQDVQVPSLDRKLGKDNSHSPSKLDVLEGGNDESVTNSVSNKQQDVQVPSLDGKLGKDNVDIPLNLDVVEGGNGKSVTKPISKKKLAKKTLGSRPKLSNIANRKGSIYSSKIASDNHSTISMDGDNERAAHKGASELETCPPTINLDAAKDVEKVTKCQNIGTSKTQFMDDETQAPDEEDDNGSKKVTGVEKSELVEVMHKADMLVETEHVRHDPKVAVHASPVASENATNGADPERAVGSKNSEFGEPTLKSGGLRKTNKRKKQLSGKARMKAVPSNSKNDLAGENTSVEKNADDKDNEKENFMPHPDDKPSGANASSKVEISGAAGKGDTVGLKEIARKSVGKPNNKTLKTKEKSQKVDMQPVQKVFKRVKIEPTCFILSGYRQQRKEFQLVIKRLKGKFCRDSHQWSYQATHFIAPDPIRRTEKFFAAAASGRWILKPEFLSACNEAGNFLAEEPYEWHKNGLSEDGAINLEAPRKWRQLKERTGHGAFYGMRIIVYGECIAPPLDTLKRVVKAGDGDILATCPPYTRFLKSGVDFAVVSPGMPRVDIWVQEFLKHEVPCVVADYLVEYVCKPGYSLEKHVLYDTHEWAEKSFTNLTTRAEEIVDDLTHESPGSSESNDITCQVCGSGDREDVMLICGNESGSVGCGIGIHIDCCDPPLDNVPEEDWFCPKCNKSSINNTSSKRRKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYC6</accession>
    <name>A0A0D2PYC6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">COBRA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G200100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COBRA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYC6"/>
    <dbReference type="STRING" id="29730.A0A0D2PYC6"/>
    <dbReference type="Gramene" id="KJB51072">
        <property type="protein sequence ID" value="KJB51072"/>
        <property type="gene ID" value="B456_008G200100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB51073">
        <property type="protein sequence ID" value="KJB51073"/>
        <property type="gene ID" value="B456_008G200100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQYT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNCIMGD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052324">
        <property type="term" value="P:plant-type cell wall cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056900">
        <property type="entry name" value="COB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006918">
        <property type="entry name" value="COBRA_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673:SF68">
        <property type="entry name" value="COBRA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673">
        <property type="entry name" value="PROTEIN COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25079">
        <property type="entry name" value="COB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04833">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038122">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395308" description="COBRA-like protein" evidence="8">
        <location>
            <begin position="43"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="COBRA C-terminal" evidence="9">
        <location>
            <begin position="238"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="434" mass="48984" checksum="D72E410EF526E453" modified="2015-04-29" version="1">MRFNQSTQTRYYGCRKCCLFPGMKSICILVVVFLLMLPNADAFDPLDPTGNITIKWDIVSWTADGYVAAVTMSNFQMYRSIMNPGWTLGWQWAKKEVIWSMVGAQTTEQGDCSKFKGNVPHCCKKNPIVVDLLPGVPYNQQFSNCCKAGVMSAWGQDPTGSVSAFQVSVGLAGTSNKTVKLPKNFNLLGQGLGYTCGPAKVVPSTVYLTPDRRRKTQALMTWNVTCTYSQYLASRNPSCCVSFSSFYNETITPCPTCACGCQNKNNCVMSDSKQAHRKGINTPRKDNAPLLQCTHHMCPIRVHWHVKLNYKDYWRVKIAIMNFNYRMNYTQWTLVAQHPNLNSVTQVFSFDYKPLVPYESINDTGMFYGMKFYNDLLMQACLKEMFSQRCSLGKTRIHLPSSRGGHFLGKSTLTAMNACCHLQIPTLFYQTLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYJ9</accession>
    <name>A0A0D2PYJ9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G204900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
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                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
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                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Frelichowski J.E."/>
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                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
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                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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    </evidence>
    <sequence length="1363" mass="152144" checksum="CB878C9598CFC4F8" modified="2015-04-29" version="1">MAFSDDEEEEALIHSVSNYYFNDEKDEAVCFSQLPLQFGGKECLSGGSKKKIFLRGIADDGLLTICKHVTAWKFDLSNVGKPDISVLSKDIGWLKLQKPRKSFEPVIRSVLISVHCLHLITWNPDLSGKSLWDQLAKIFSLYEVKPSQNDLVDHMDLIAEAVKSDDSLAKSKFLHSFLEEKPKKRKLVNENARGTSISGFIVDDAVDGPELDDSNNDDDEDDLYDSVCAFCDNGGSLICCDGRCMRSFHATEDDDSARESACESLGFTPNQVKALETLLCKNCEYNQHQCFSCGKLGSSDKSSGAEVFRCSNATCGHFYHPHCVAKLLHKGDKVAAEEHAKRISSGEFFTCPTHKCCVCQQGENKKVEELQFALCRRCPTSYHRKCLPREIAFDDIEEEGIITRAWDGLLVNRVLIYCFKHEIDEDLGTPIRDHIKFPFDESKKRKASDVLTSHEKVGSKKKTLALEGTSQERTAMKAAKQSSSVVKADQTSKKSEKVTPRTNALKKVKATGPSKKPLRQNSKSLPMDAGKSSADDGNKTSLGGRLFSLMNQESEQQIKPGRQDNLKGGLSKAAVVNSTATSKSSDMPSLDADSERRLLNLMKEAESSVTLEDIITKPKVLSTHGYSSRSVIDRTITLGKIEGLVEAVRMALAKLEDGCSIEDAQAVCEPEVLNQIFKWQNKLRVYLAPFLYGMRYSSFGRHFTKVDKLEEIVDRLHWYVQDGDTIVDFCCGANDFSLIMKRKLEETGKKCSFKNYDIFQAKNDFNFERRDWMSVQQKELPTGSQLIMGLNPPFGVKAALANKFIDKALEFNPKLLILIVPPETERLDKKKSLKYPYELVWEDNNLLSGKSFYLPGSIDANDKQMDQWNVMVPPLYLWSRSDFSAKNKSIAEKHGHVPREPASSNQEMNIDETRRSDFELPLEDDGLRDDATELKDHMQNHVIEECKKEKSVEVTPKECSPRQQSDEKNQSKETSSNKKRKHSEENNGRKTDKKSGGRTPRSETHDGIPHSSPSNVMGSSRSSVEGASSKLHSEENLVRKTDIKGGGRIPRSEMHSGIPHPSPSNVIGSSRSSVKGASPKLHSEENLGRKTDKMSGGRTPRSETHGGIPHSSPSNVMGSSRSSVEGASKLHSEENLGRKTNKKSGRTTRSETYSGIPHSSPSNVMASSRSSVECASRSPNQHRIPNMRSSQTALRTSYGDTRTSVGDDMGRRYNMNYDPYSAGTHSHGYRPYPNEMNREFNLRSQVHLYGQEPGLFPRRNDLAGLNSLYGPTTPSYGQHNGATVNPSYRMNMSAMQRYAPRLDELNYTRMGGAGPEPPLMGNRNTFYDPRPPFMIDPRAPRPPYTLGFSPGPYHPYSHHNSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5P7</accession>
    <name>A0A0D2Q5P7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_006G084600</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q5P7"/>
    <dbReference type="Gramene" id="KJB34803">
        <property type="protein sequence ID" value="KJB34803"/>
        <property type="gene ID" value="B456_006G084600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000002">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000343">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1083">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 18" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249506" description="Protein kinase domain-containing protein" evidence="18">
        <location>
            <begin position="24"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="109"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="306"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="578"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB34803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="606" mass="67155" checksum="72E4499699E422A9" modified="2015-04-29" version="1">MGWSVPLFSYSLVLSFLPTLIVAQLNPVYFEHDCNQGSGNYTPNNTYEANLNSIISRFATLSYFNYGFFNLSAGESPNKFCPRNKVAIAWSELCLVRYANRDLYGLLENDPRTCKYNPMNASNPAQFNRALSELLNNLSSEAAASGPLRKYAAGNALTGILQMVYATVQCTPDMDQQNCTACLNYGRSELGGCCYGRMGCRILRPNCVLRFESNPFYNETAVPLPSPPTTSSPTPSPGNGNNTTRTVIIVIASVVGLLILIIIAICIFKRPKRNKDISIKDADNEMSGADSLQFGFDSVLVATDNFSDANKLGQGGFGAVYKGQLPNGEEIAVKRLSKGSGQGDLEFKTEVQLVAKLQHRNLVRLLDRIRRAELDWETRFKIIHGIVRGLLYLHEDSRLRIIHRDLKASNILLDAEMVPKIADFGMARLFGQDETQGSTSRIVGTHGYMAPEYVFHGQFSVKSDVFSFGVLLLEIISGQRNNSFRYDEQYEYILGFAWRSWREGTALNLVDPTLGDSSRNEIMRCIHIALLCVQEKVAARPTMASVVLMLNSFSTTLALPAQPAFVMRSNFNFDMSTSSASASNQSNTELPPLPRNEVSISELSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q9Z1</accession>
    <name>A0A0D2Q9Z1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Peroxidase</fullName>
            <ecNumber evidence="4 19">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_006G143400</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="16 19">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 19">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="16 19">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 19"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q9Z1"/>
    <dbReference type="SMR" id="A0A0D2Q9Z1"/>
    <dbReference type="STRING" id="29730.A0A0D2Q9Z1"/>
    <dbReference type="Gramene" id="KJB36143">
        <property type="protein sequence ID" value="KJB36143"/>
        <property type="gene ID" value="B456_006G143400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799557"/>
    <dbReference type="eggNOG" id="ENOG502QVXS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF139">
        <property type="entry name" value="PEROXIDASE 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 19" id="KW-0349">Heme</keyword>
    <keyword evidence="13 19" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 16 19" id="KW-0408">Iron</keyword>
    <keyword evidence="20" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 19" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0964">Secreted</keyword>
    <keyword evidence="20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="21">
        <location>
            <begin position="35"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="17">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="45"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="78"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="131"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB36143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="339" mass="35973" checksum="BE858158FD0907F5" modified="2015-04-29" version="1">MKSSTTMLPSNIANYASFFLLIISIILLIVGSKAQLNSTFYDNTCPNASSIVRGVIQQALQSDVRIGASLIRLHFHDCFVNGCDGSILLDNSANIQSEKDAAPNTNSTRGFNVVDNIKTALENSCPGIVSCADILALAAEASVSLQGGPSWTVLLGRRDSLTANQAGANSSIPTPFESLTNITAKFTAVGLNTNDLVALSGAHTFGRAQCRLFSSRLYNFSGTGNPDPTLNSSYLTTLQQICPQSGSGFNVANLDPTTPDTFDNNYFTNLQNNQGLLQSDQELFSTSGAPTISIVNTFSSNQTAFFQSFAQSMINMGNISPLTGSNGEIRSDCKKVNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBW3</accession>
    <name>A0A0D2QBW3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRISC and BRCA1-A complex member 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">BRCA1-A complex subunit BRE</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">BRCA1/BRCA2-containing complex subunit 45</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_002G123300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the BABAM2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QBW3"/>
    <dbReference type="STRING" id="29730.A0A0D2QBW3"/>
    <dbReference type="Gramene" id="KJB14391">
        <property type="protein sequence ID" value="KJB14391"/>
        <property type="gene ID" value="B456_002G123300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784414"/>
    <dbReference type="eggNOG" id="ENOG502QUU0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGSTWRH"/>
    <dbReference type="OrthoDB" id="538811at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070552">
        <property type="term" value="C:BRISC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010358">
        <property type="entry name" value="BRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15189:SF7">
        <property type="entry name" value="BRISC AND BRCA1-A COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06113">
        <property type="entry name" value="BRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB14391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="43581" checksum="E73B3D539CF25828" modified="2015-04-29" version="1">MSLDGFPPFISAQLHYLINHFPDKIKVEQVLSGGKTYTGGLDRFTLLIPYCLDYIKWDIIYNAEFPLAPPDIIFGTEDEDFHPLHMTGRVGEGDLKFRNILSDWNYKDPTRLLALIQELRDRYMAYQKKRVGEVDDDRLTFEISTICSREGIEMQISSGAEKPEEVKFAVPLMDMNINKMVHGCPWRHPQKIYLQVIYPVGKKYASTPSAPRLKLMSTTELRALFTIEDVKLPSWLDGMCMAEYLPHLEESLQKQVLEAVSLIDIRRHFIEALAPLLGRPLEADPVFCRKATFLASSGSFVFLVHFHISTLFPKQQPALMLQSSQHISPQGIPKKSPLLAEYPWSPRWEASQMAERIFDFLADESLNFKRFCNESQPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCW5</accession>
    <name>A0A0D2QCW5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G188200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QCW5"/>
    <dbReference type="STRING" id="29730.A0A0D2QCW5"/>
    <dbReference type="Gramene" id="KJB37063">
        <property type="protein sequence ID" value="KJB37063"/>
        <property type="gene ID" value="B456_006G188200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000024">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 5, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="10">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB37063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="247" mass="28635" checksum="C10088CFF92745FA" modified="2015-04-29" version="1">MCVFVRARAFLMLYFSISRMPSICFQCFKEENGDPYESQFFFSLFRLGYILRVVWSLQYWLKMSSPSKRREMDVMKLMMSDYNVETINDGLNEFNVKFHGPKESLYEGGVWKIRVELPDAYPFKSPSIGFVNKIFHPNVDELSGSVCLDVINQSWSPMFDLLNIFEVFLPQLLLYPNPSDPLNGDAASLMMKDRKQYDQKVKEYCERYAKKEDITKSAADKETDDEDDITDEDTGSSDDEIAGHADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFL9</accession>
    <name>A0A0D2QFL9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G232500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QFL9"/>
    <dbReference type="STRING" id="29730.A0A0D2QFL9"/>
    <dbReference type="Gramene" id="KJB38013">
        <property type="protein sequence ID" value="KJB38013"/>
        <property type="gene ID" value="B456_006G232500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38015">
        <property type="protein sequence ID" value="KJB38015"/>
        <property type="gene ID" value="B456_006G232500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800461"/>
    <dbReference type="eggNOG" id="ENOG502QS91">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GASYWLF"/>
    <dbReference type="OrthoDB" id="551300at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071277">
        <property type="term" value="P:cellular response to calcium ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009704">
        <property type="term" value="P:de-etiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090333">
        <property type="term" value="P:regulation of stomatal closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044690">
        <property type="entry name" value="CAS_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34209">
        <property type="entry name" value="RHODANESE/CELL CYCLE CONTROL PHOSPHATASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34209:SF3">
        <property type="entry name" value="RHODANESE_CELL CYCLE CONTROL PHOSPHATASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="381"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="605"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB38013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="652" mass="71086" checksum="239AD04524DF0672" modified="2015-04-29" version="1">MLPVCSAAAGCSSHSQISFHGGFRPFTPYEKDFQFRCSSQDKSALGMSNGNHLHRMYFKPQATKSFYSDFVESTEQRVSMDLINSYSSPDELVDVKCKISNAWSSSVEAIMSPTDVELKYVENSSISSAEEKLVDLSNQSVENVNNYTGMEGPETISTIDTIPETPTAASSSVNFDNDSLSSVKTGLDDFLAGVNKSVNSSLDKGENAVKNLLEKITSSITSVKTSTSEAVDNAQVLVNNKLSNLSNDMKEASSKANIFAVDLLRRTIVVVEDSLSNGASTFVYYYASAKERLPPEIKDTLTLYEERTGKALKPIGDALQQVYIGIEGLERSLGFDPNDPVVPFFLLTGTSATLWVFYRVWAYGGYSGDLSPQLTLELLSGKENVLLIDVRPEVLRERDGIPDLRRAARSRYASVSLPEVNGSIRKLLKSGRDLDDTLIATVIRNLKIVEDRSKVIIMDADGSRSKGIARSLRKLGVKKPYLVQGGFQSWVNQGLRIKELKPETALTILNEEAEAILEEISPSPVQVLGYGVGLVAAIYALLEWEKSLQLIGILGLVLTIYGRVSSYESSEDLKKDIRLLLAPVTFGAQAFSWVSGKLETNGIGLPTSPSSSDVQSRVLQAAAKHESKPSDSEDPSADAMAPRNEKADLSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QI12</accession>
    <name>A0A0D2QI12_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G095100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QI12"/>
    <dbReference type="STRING" id="29730.A0A0D2QI12"/>
    <dbReference type="Gramene" id="KJB19319">
        <property type="protein sequence ID" value="KJB19319"/>
        <property type="gene ID" value="B456_003G095100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB19320">
        <property type="protein sequence ID" value="KJB19320"/>
        <property type="gene ID" value="B456_003G095100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788397"/>
    <dbReference type="eggNOG" id="KOG2680">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGMRYAI"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB19319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="465" mass="51553" checksum="5206DEFA0D00F310" modified="2015-04-29" version="1">MTELKLSESRDLTRIERIGAHSHIRGLGLDSSLEPRDVSEGMVGQAQARKAAGVILQMIKDGKIAGRAILLAGQPGTGKTAIAMGMAKSLGLETPFSMLSGSEIFSLEMSKTEALMQAFRKSIGVRIKEETEIIEGEVVEIQIDRPAVSGAASKTGKLTLKTTDMETVYDLGAKMIEALGKEKVQSGDVIAIDKASGKITKLGRSFSRSRDYDAMGPQTKFVQCPDGELQKRKEVVHSVTLHEIDVINSRTQGFLALFTGDTGEIHAEVREQIDTKVAEWREEGKAEIVPGVLFIDEVHMLDIECFSFLNRALENEMAPILVVATNRGITSIRGTNYKSPHGIPIDLLDRLLIITTQPYSEDEIRKILDIRCQEEDVEMFEDAKQLLTKIGHETSLRYAIHLITASALNCRKRKGMVVEVQDITRVYSLFLDVRRSTQYLMEYQKEYMFNEASIVDGGDADAMHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNV8</accession>
    <name>A0A0D2QNV8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G083300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNV8"/>
    <dbReference type="Gramene" id="KJB40933">
        <property type="protein sequence ID" value="KJB40933"/>
        <property type="gene ID" value="B456_007G083300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHRMRRW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057291">
        <property type="entry name" value="CHX17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057290">
        <property type="entry name" value="CHX17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF18">
        <property type="entry name" value="CATION_H(+) ANTIPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23256">
        <property type="entry name" value="CHX17_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23259">
        <property type="entry name" value="CHX17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="39"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter central" evidence="12">
        <location>
            <begin position="461"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter C-terminal" evidence="13">
        <location>
            <begin position="604"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB40933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="779" mass="86815" checksum="FC0A1C2B7B14042E" modified="2015-04-29" version="1">MEAAEKATCRSVDNFNPLITTIFQVSCILVISHMFHILLKPLGQPGPFAGVVVGPTLLSRIRRVEDFFIQASSAEYYMFFSFLCRMLFMFSIGLETDIPYLKRNIRVVSIVAGGGIILSSICAAPLLWLLIKVFTVTKSRFPFYLLIFTVLANSASPVVIRMIAESKFDNADLGRLAIYSSLISEMSCVAFVATLTACSSTIRLVGAIIATLVTVLLIFLNNYLPFVFNKRNRHNRFLTNSELFLIIFILLAISLLVESAGYTAITCCFLAGLMFPREGKTCRTLLHKLTYAVNTFVLPVYFGYTGFQFNISKIFNKLTLILTVLIILLSAGTKIVATLAACYYLKIPRNESLILSFLLNMKGNYDLIIINSPPVPKMLWENDIHDLFLSVVVLKTLILAPVVAIWLNRGEFCGHYPTTLEILNPESELRMMACAYIPRHVSGYLSLISALSGCPNATLNPYVAHLVELRKKKKSKLMYHQLEDGDQYSDEEEYGGNDVVQITNALDSFISETKIPVHEAKIVSSFLTINQDVCNGAVDLRVSIIFLPFHKHQRVDGKMENSMEGIRTINQKVIRHAPCSVGIFLDRGQTGFQQPHGSLSVQNIATFFFGGPDDREALACSKRILMHSQVSLTVFRFIQANSSIQNSWISDASHKDEEVVMAISSIGTENEMDNVFVDSFYNRYVAQGKASLIEKYVSDGAETLVALREILDNMYSLVIVGKGGRENSSLTIGMSDWEECPELGLVGDLLASSEMNFSGSLLVIQQHRHSEEDEAFITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRC0</accession>
    <name>A0A0D2QRC0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G165300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRC0"/>
    <dbReference type="STRING" id="29730.A0A0D2QRC0"/>
    <dbReference type="Gramene" id="KJB09780">
        <property type="protein sequence ID" value="KJB09780"/>
        <property type="gene ID" value="B456_001G165300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3291">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="316" mass="35340" checksum="7FCD0995DFEF0D24" modified="2015-04-29" version="1" fragment="single">MPLPKAKQEETYGGPRSPLGRRQKSLPLKTEGTSDYSKPKRTRRGIGSPFTLFLGRNSGNGNSKPLSGWLNGFGRILNKRVCEIPVPLFFAARPFNQQISDVMKQLSKKAASNCSEILSYMGGLDGEQKQLIKKLVNFRMKEENIKPICEVEKVRIAGTIYDVPGIVAKDRQQTLAIRWILEAAFKRRISYRISLEKCSFAEILDAYRKRGIARKKRENLHGLSSTNRIGPFTPFRLTRGADLINALQREGSQVSHVVNFWGQAKVRARHLAMNSVTGSLSLCLTLASQVGIDSSERWACHVKAGPSNDCTKSLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QST0</accession>
    <name>A0A0D2QST0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G129600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QST0"/>
    <dbReference type="STRING" id="29730.A0A0D2QST0"/>
    <dbReference type="Gramene" id="KJB20031">
        <property type="protein sequence ID" value="KJB20031"/>
        <property type="gene ID" value="B456_003G129600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788793"/>
    <dbReference type="eggNOG" id="ENOG502QV99">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTFAECV"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06544">
        <property type="entry name" value="GH18_narbonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000677">
        <property type="entry name" value="Chitinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476:SF13">
        <property type="entry name" value="2, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46476">
        <property type="entry name" value="CHITINASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00551">
        <property type="entry name" value="2SGLOBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250560" description="GH18 domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="6">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB20031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="306" mass="34031" checksum="AB7619362F1294D7" modified="2015-04-29" version="1">MEFSKLLISLFIFQVFFPCHMSIQAAPANSDLFREYIGAEFNNVKFSDVPINSNVEFHFILSFAIDYDSTTGSPSPTNGKFNVFWDSDNLSPSQVSSIKSTHSNVKVALSLGGDSVGDGYAYFDPSSVDSWVSNAVSSLTNIIQEYHLDGIDIDYEHFNADPDTFSECIGELIKTLKNNGVISFASIAPFDDDDVQSHYKALWKSYGDLIDYVNFQFYAYDQGTTVSQFMNYFNTQSSNYNGGKVLASFISDGSGGLTPENGFFTACSRLKSENKLHGIFVWSADDSKRNGFRYEKQSQALLAISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QT59</accession>
    <name>A0A0D2QT59_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G151200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QT59"/>
    <dbReference type="STRING" id="29730.A0A0D2QT59"/>
    <dbReference type="Gramene" id="KJB42408">
        <property type="protein sequence ID" value="KJB42408"/>
        <property type="gene ID" value="B456_007G151200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803255"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVWFGSN"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20618">
        <property type="entry name" value="CYP71_clan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000038">
        <property type="entry name" value="Cytochrome P450 84A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944">
        <property type="entry name" value="CYTOCHROME P450 98A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47944:SF4">
        <property type="entry name" value="OS09G0441700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="58404" checksum="D7E3B9BC5435C86D" modified="2015-04-29" version="1">MESPSWVSYLTAWLATLALILLSLRFRPRRKLNFPPGPKPWPVIGNLDLICSLPHRSIHALSQKYGPLMQLKFGSFPVVVASSVEMAKAFLKTHDVIFAGRPKIAAGEYTTYNYSDITWSPYGPYWRQARKMCMTELFSAKRLESYEYIRREEMKLLLKGLYESSGVPIVLKDRLSDLSLNVISRMVFGKKYTEGTGENEIVTPKEFKEMLDELFLLNGVLDIGDSIPWLRFLDLQGNIKRMKALSKKFDKFLEHVLDEHNARRRDVKDYVAKDMVDVLLQLADDPNLDVKLERHGVKAFSQDMIAGGTESSAVTVEWAISEMLKKPEIFAKATEELDRVIGRERWVEERDIENLPYIDSIAKETMRLHPVAPMLVPRMTREDCQVDGYDILKGTRALVNVWTIGRDPTVWDNPNEFCPERFIDKTIDVKGHDFQLLPFGAGRRMCPGYPLGIKVIQASLANLLHGFTWKLPGNMTKEDLDMEEIFGLSTPKKCPLQAVAVPKLPLHLYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVU1</accession>
    <name>A0A0D2QVU1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G112700</name>
        <name evidence="13" type="ORF">Gorai_014562</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVU1"/>
    <dbReference type="STRING" id="29730.A0A0D2QVU1"/>
    <dbReference type="Gramene" id="KJB23744">
        <property type="protein sequence ID" value="KJB23744"/>
        <property type="gene ID" value="B456_004G112700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791096"/>
    <dbReference type="eggNOG" id="ENOG502S5ED">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NANMSAC"/>
    <dbReference type="OrthoDB" id="664243at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220038" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="10">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="114"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB23744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0583716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="192" mass="19713" checksum="BFED2392B46C40A3" modified="2015-04-29" version="1">MAALAFTPILMLLLLVASLPTSLSQDPITPGPTVSDCSPRLVALMPCAPFVQGNAPRPAQSCCDNLNQLYGLQPGCLCLLLNDTTLSAFPINRTLAQQLPVLCKLQANSSSCSGLPSPPGSSGSQVSLGTNHNSSVAASSPMGNPNVPVAPRPSIMGLGFGRSKAGRLKAQGLLAMVAAAVILCSRLALPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R500</accession>
    <name>A0A0D2R500_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G365200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R500"/>
    <dbReference type="STRING" id="29730.A0A0D2R500"/>
    <dbReference type="Gramene" id="KJB46393">
        <property type="protein sequence ID" value="KJB46393"/>
        <property type="gene ID" value="B456_007G365200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYAQMIL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF51">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB46393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="192" mass="22102" checksum="DAEC87BA1C6A7E59" modified="2015-04-29" version="1" fragment="single">MGRNPSKVFYCPNIIQCYGGFTTLEREQGMIYNILDEKYDVKIPERDVNYYAQMILEVLLDIHEKRFIHSDLKPGNILVFPPQHGANLSTLKTADFGLAKQLGVKDTRFEFQGIRYYMSLGSIFEEVSGALDIWSLGCIEVQMIMGKLPWDTRDRDELRDKFLRGESANILEDMSKLGNSFLKECFAIDPNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R513</accession>
    <name>A0A0D2R513_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HTH cro/C1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G271900</name>
        <name evidence="9" type="ORF">Gorai_015679</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MBF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R513"/>
    <dbReference type="SMR" id="A0A0D2R513"/>
    <dbReference type="STRING" id="29730.A0A0D2R513"/>
    <dbReference type="Gramene" id="KJB26999">
        <property type="protein sequence ID" value="KJB26999"/>
        <property type="gene ID" value="B456_004G271900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792813"/>
    <dbReference type="eggNOG" id="KOG3398">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKICERQ"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.40:FF:000018">
        <property type="entry name" value="Multiprotein bridging factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF117">
        <property type="entry name" value="MULTIPROTEIN-BRIDGING FACTOR 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="7">
        <location>
            <begin position="86"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB26999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0584884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="142" mass="15529" checksum="11120E5B104FEEEE" modified="2015-04-29" version="1">MAGIGPLTQDWEPVVIRKKAPTAAAKKDEKVVNAARRAGAEIESVKKSNAGTNRAASSSTSLNTRKLDEETENLAHDRVPTELKKAIMHARVEKKLTQAQLAQLINEKPQIIQEYESGKAIPNQQIIGKLERALGAKLRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFC5</accession>
    <name>A0A0D2RFC5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G021800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the C-terminally encoded plant signaling peptide (CEP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFC5"/>
    <dbReference type="Gramene" id="KJB17885">
        <property type="protein sequence ID" value="KJB17885"/>
        <property type="gene ID" value="B456_003G021800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S95G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902025">
        <property type="term" value="P:nitrate import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901371">
        <property type="term" value="P:regulation of leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033250">
        <property type="entry name" value="CEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348">
        <property type="entry name" value="PRECURSOR OF CEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348:SF44">
        <property type="entry name" value="PRECURSOR OF CEP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250135" evidence="8">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB17885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="88" mass="9649" checksum="A1B5E9CCEF1C7415" modified="2015-04-29" version="1">MANLRCNCLFFLLMILVLSHETLLFTEGRSLELKTRLGHGNLFGHGEGNGKSINVAIPSPLHHVFRSLEGYIDAFRPTTPGHSPGVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHL6</accession>
    <name>A0A0D2RHL6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G083600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHL6"/>
    <dbReference type="STRING" id="29730.A0A0D2RHL6"/>
    <dbReference type="Gramene" id="KJB29086">
        <property type="protein sequence ID" value="KJB29086"/>
        <property type="gene ID" value="B456_005G083600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797102"/>
    <dbReference type="eggNOG" id="KOG2248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTQFSKL"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF157">
        <property type="entry name" value="SMALL RNA DEGRADING NUCLEASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="7">
        <location>
            <begin position="208"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB29086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="564" mass="62953" checksum="9BE7E71B3199384F" modified="2015-04-29" version="1">MASLKEKSEEAIPEEEKKESSNYFDIYGPQAKAELVFKTPEADSTLNLQDVQGLVTWVLADGFMPSWVFIKNKPLIPKVVMLYVPGLDAALYIAQSMKLSGFKQSCGNPRALLALSCVSDGMQTIDALLTCKVKRKRNVIDSARDVSQSAEQETSISSMDSAEILKDIPFPISYYTLTAKELEDNGFCYDQPGFIPTRPAPDGSSPYEMLALDCEMCITSEGFELTRVTLVDIKGQVVLDKLVNPSNPITDYNTRFSGITYEMLSGVTTTLQNVQEDFLMLVHKDTILVGHSLENDLLALKISHDLIIDTSVLYKHPRGGSYKSALRVLAKRFLSREIQQSGSGHDSIEDARAAMDLALLKIRNGPDFGSPPSFMRRKLLTLLGECGKTSSFIDDISIVKRYASESSHAIPVCSDDEALLKARKEVKNDRVHFVWTQFSELNSYFRKQAEDDVKLNGKLAEMISLLTCDKKPAKRKGVKYNISTELKEILTRIDARVRSLHTALPTNSMFIICTGHGDIAIVHRLRKMLTEQSETMIPREKLIKVLEELQAQAEVALCFVGMKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIL5</accession>
    <name>A0A0D2RIL5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G102200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIL5"/>
    <dbReference type="ESTHER" id="gosra-a0a0d2ril5">
        <property type="family name" value="Triacylglycerol-lipase-OBL1-like"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB29466">
        <property type="protein sequence ID" value="KJB29466"/>
        <property type="gene ID" value="B456_005G102200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796133"/>
    <dbReference type="eggNOG" id="KOG4569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKHYGSC"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044819">
        <property type="entry name" value="OBL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46086">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46086:SF4">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="202"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB29466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="471" mass="55078" checksum="FB2DD13CCB162EBD" modified="2015-04-29" version="1">MASNKNRFYDDCFIINSEKASYLDLLGLLVSSKLKQRRFIDAPEQHNHRFRRRLVVFGMVLLQKLLSLVRIPLALTEIVVVTLLNLLTYNGGLSGLLLNLMKGKLVWPEKSSEMYRSMLGNVDTRVELDNNIKPGDPKYKALLSMMASKLSYENEAFIKTVIIQHWKMKFLKFYSFWNDFEERSTTQAFMMQDTQSNPNLIVVAFRGTQPFSAYDWKTNVDISWYELKDMGKGKIHSGFMKALGMQKTKGWPKEIQQSTHQNQFAYYTLRQKLREVLQENQDARLIVTGHSLGSALAVLFVAVLMLHEEEWLLEKLEAVYTFGQPRVGDHKFGEFMIDKLRKFDVKYFRYVYSNDMVARIPPDDDTFLSKHFGPCFYFNSFYNGKVLSEEPNKNYFSWLWEIPKRMIAVWELIRAFILPYMKGPEYKENWVMITLRIMGLVTPGMSAHMPQDYVNSIRLGTLPSVHQLKRD</sequence>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Mansoor S."/>
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                <person name="Rainville L.N."/>
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                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Dennis E.S."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB20905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0582845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="67755" checksum="9EDB45EDD4DD899F" modified="2015-04-29" version="1">MIMKWKLHKTVLPRFHQIGNHYSLLHIKTNSSSSSSSSSFNGVYSTTNSSEKGNRKKYEFHNIVDALTLFNKMTHASPKPCIVEFNKLLGSIVGMKHYAIVVSLCKQMELLGIRHDVYTLNILMNCFCLSNCVSFGFSVLGKMLKLGYRLNLVTYSTLIKGFCTQGKVGQAGKLFDEMVLMGFRPDLYLYTIMVNGYCKMGNSDGAVRMLREMKERGFRLDLVAYTSVIDCLFKTKYISEALDIVDEMKGKGIQLDVVTYSSLIRAMCSLGNWSEVKRLLNEMESNDLKLNVVTFNILVGGFCKEGKISEALGVVAMMTRKGVWPNVITYSELINMYCLQGELDEARKVFDSMVNLGCERNVFSYNIMINGYCKTNKIEEALKLFHEMTQKGPAPDVATYTSLMRCMFQVGRLSDAEELFENMRACGQVPNHITYSVLLDGLCKRGQIDVALELFHAVQNNELEPYIFHYNILLDGLIEAKHFEAATRLFSHVFAIGLKPSLPTYNIMIKGLCNEGLPEKAYDLFRKMEEDDCFPNNISYNITIRGFLQRNDMSKAMKILHEMVDKGFSADSLTVVKLVTLLAVTEEDQPTYEIRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQI2</accession>
    <name>A0A0D2RQI2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B456_005G210100</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="21">Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells. Required for the normal functioning of the plasma membrane in developing pollen. Involved in the regulation of cell expansion and embryo development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2RQI2"/>
    <dbReference type="Gramene" id="KJB31831">
        <property type="protein sequence ID" value="KJB31831"/>
        <property type="gene ID" value="B456_005G210100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794950"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000372">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000278">
        <property type="entry name" value="MAP3K epsilon protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000304">
        <property type="entry name" value="MAP3K epsilon protein kinase 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052441">
        <property type="entry name" value="Armadillo-Ser/Thr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46618:SF1">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="20"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="394"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="830"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00054419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJB31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1428" mass="156986" checksum="57D8DAC9D99F5C4B" modified="2015-04-29" version="1">MSRQAASSAFHKSKTLDNKYMLGDEIGKGAYGRVYKGLDLENGDFVAIKQVSLENIAQEDLNIIMQEIDLLKNLNHKNIVKYLGSSKTKSHLHIILEYVENGSLANIIKPNKFGPFPESLVAVYISQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLTEADVNTHSVVGTPYWMAPEVIEMSGVCAASDIWSVGCTVIELLTCVPPYYDLQPMPALFRIVQDEHPPIPDSLSPDITDFLRQCFKKDARQRPDAKTLLSHPWICNCKRALQSSLRHGGTIRNISEDIAANAESSGGDNQSAGESLPVEKVEASETSSGKEFLLAEVTHQQSAYQERVLEETANNLDNDLLSDQVPTLAIHESLSLQSSSGRLSVKNVVAAHASDQLHDTSNQDEVTINGDVGSPESRRKHTEKGHGGKGSSIDIEDASFGFGPITQDAGLQKAVKASVISTGNELSRFSDSPGDASLDDLFHPFDKNLVESAAEASTSAAASNVNKATLPDTGKNDLAKKLRDTIAKKQMEEQMGQSNGGGNLLRVMMGVLNDDVIDIDGLVFGDEKLPADNLFPLQAVEFSRLLSSLRPEEPEDAIVTACQKLIAIFHLRPEQKVAFVSQHGLLPLMDLLDVPRTRVICYVLQLINQIVKDNTDFQENACLVGFIPFVMSFAGPDRPREIRMEAACFLQQLCLSSSLTLQMFIACRGIPVLVGFLEADYAKYREMVHLAIDGMWQVFKLQRSTPRNDFCQIAAKNGILLRLINTLYSLNEATRLATISVGGGFAVDGSAQRKRSGPLDSSHPLFAQNDTPLSLTDQSDLKVRHGIIDHSFPTVPQEPSRASTSLSQRSDANLPDSRYLAIDSNKPQFSNGVLDVSVGSKLAELTSLEKLSNLATKEASTISRDRENSDRWKLDSARAELDFRHQRTSTSASRTSTDRPPKLIEGISNGFPTSVTTQAQQVRPLLSLLANEPPSRHISDQLEYVRHLPGSERRESILPLLHANNDRKTNGELDFLMAEFAEVSGRGRENGVVDPTPRISNKTVSKKVGQLGFSEGVASTSGIASQTASGVLSGSGVLNARPGSTTSSGLLSNMVSTMNADVAREYLEKVADLLLEFAQADTVVKSYMCSQSLLNRLFQMFNRIEPPILLKILKCINHLSTDPNCLENLQRADAIKYLIPNLELKDGPLVSQIHHEVLNALFNLCKINKRRQEQAAESGIIPHLMNFIISDSPLKQSALPLLCDMAHASRNSREQLRAHGGLDVYLSLLDDELWSVTALDSIAVCLAHDNDNRKVEQALLKKDAVQRLVKFFQCCPEQHFVHILEPFLKIITKSSRINTTLAVNGLTPLLISRLDHQDAIARLILLKLIKAVYEHHPRPKQLIVENDLPQKLQNLIEERRDGQRSGGQVLVKQMATSLLKALHVNTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQQ9</accession>
    <name>A0A0D2RQQ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G163400</name>
        <name evidence="5" type="ORF">Gorai_014922</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQQ9"/>
    <dbReference type="STRING" id="29730.A0A0D2RQQ9"/>
    <dbReference type="Gramene" id="KJB21445">
        <property type="protein sequence ID" value="KJB21445"/>
        <property type="gene ID" value="B456_004G163400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791660"/>
    <dbReference type="eggNOG" id="ENOG502S3J8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFCHEGG"/>
    <dbReference type="OrthoDB" id="1026046at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374">
        <property type="entry name" value="AUXIN-INDUCED PROTEIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374:SF388">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN SAUR36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB21445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0584092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19629" checksum="1056FDF2076228E5" modified="2015-04-29" version="1">MRKIRGFKIGKRLVRISRWFIRKARHPRGYCRLTQSESKSFCKSKSFSKLISWGQCLTKRAKSICSSKPGLGYVPIGQDPINEKLTEVPKGHLAIYIGQKDGDYHRVLVPVIYFNHPLFGELLREAEEEYGFSHQGGITIPCRFSEFERVQTRIAAGTGGRKMVWKRHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRG8</accession>
    <name>A0A0D2RRG8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_009G004400</name>
        <name evidence="18" type="ORF">Gorai_010781</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADAGIO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0593851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRG8"/>
    <dbReference type="STRING" id="29730.A0A0D2RRG8"/>
    <dbReference type="Gramene" id="KJB53773">
        <property type="protein sequence ID" value="KJB53773"/>
        <property type="gene ID" value="B456_009G004400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767369"/>
    <dbReference type="eggNOG" id="ENOG502QQR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REICGIF"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22154">
        <property type="entry name" value="F-box_AtADO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000021">
        <property type="entry name" value="Adagio protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000041">
        <property type="entry name" value="Adagio protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000005">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000062">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175:SF5">
        <property type="entry name" value="ADAGIO PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB53773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0593851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="610" mass="66390" checksum="7C6CC88794B49E76" modified="2015-04-29" version="1">MEWDSNSDLSGDEDEGFLLNDGAPVPFPIPTSLQTAPCGFVVTDALESDHPIIYVNTVFEMVTGYRAEEVLGRNCRFLQCRGPFAKRRHPLVDSTVVSEIRRCLDEGIEFQGELLNFRKDGSPLMNRLRLTPIYGDDETITHVIGIQFFTEANIDLGPVSVSSIKESLKSSDRSRTGFSAFCPVVVGDRNVSRGLCGILQLSDEVLSLKILSRLTPRDIASVGSVCRRLYELTKNEDLWRMVCQNAWGCETTRVLETVPGAKRLGWVRLARELTTLEAAAWRKLTVGGAVEPSRCNFSACAVGNRVVLFGGEGVNMQPMNDTFVLDLNSSNPEWQHVQVSSPPPGRWGHTLSCVNGSHLVVFGGCGRQGLLNDVFVLDLDAKPPTWREISGLAPPLPRSWHSSCTLDGTKLIVSGGCADSGVLLSDTFLLDLSMEKPVWREIPVAWTPPSRLGHTLSVYGGRKILMFGGLAKSGPLRFRSSDVFTMDLSEEEPCWRCVTGSGMPGAGNPGGIAPPPRLDHVAVSLPGGRILIFGGSVAGLHSASQLYILDPTDEKPTWRILNVPGRPPRFAWGHSTCVVGGTRAIVLGGQTGEEWMLTELHELSLASSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RWP5</accession>
    <name>A0A0D2RWP5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G086400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RWP5"/>
    <dbReference type="STRING" id="29730.A0A0D2RWP5"/>
    <dbReference type="Gramene" id="KJB55638">
        <property type="protein sequence ID" value="KJB55638"/>
        <property type="gene ID" value="B456_009G086400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767458"/>
    <dbReference type="eggNOG" id="KOG2692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVCNSSH"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19952">
        <property type="entry name" value="GT29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46779">
        <property type="entry name" value="BETA-1,6-GALACTOSYLTRANSFERASE GALT29A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46779:SF1">
        <property type="entry name" value="BETA-1,6-GALACTOSYLTRANSFERASE GALT29A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB55638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="447" mass="51134" checksum="4AF2B4BAAD4E3C25" modified="2015-04-29" version="1">MVSFLCLNPSSLFGIPNEPEDGSESDTDLLKIRTFFLFWPYLANPIYRPPNVILLMKRSFRPLISILMLVALTATLSCRIASPRRGVFTVSAELESTPVLIQPPQIQVFNSTLLKFASIDIGEAKSKLEIKQLLERDFPNQGRQRNFATSRSSSHHDAKSKNSNGLPVLLRSPKFYRYWLDFRRNLQLWARKKTFQPDIMMDLVSLVKTPIDRHNGLMSSARKYKSCAVVGNSGILLNRDYGELIDGHEIVIRLNNARTEKFEEQVGSKTSISFVNSNILHLCARREGCFCHPYGRNVPMIMYICQPVHFMDYTVCNSSHKAPLLITDPRFDVLCARIVKYYSAKRFLEETRKALGEWASTHDGSMFHYSSGMQAVMLALGICDKVGIFGFGKSTSAKHHYHTNQKSELRLHDYEAEYAFYHDLVKNPQAIPFISDRFRFPPVVIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RWY0</accession>
    <name>A0A0D2RWY0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G041800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RWY0"/>
    <dbReference type="Gramene" id="KJB33981">
        <property type="protein sequence ID" value="KJB33981"/>
        <property type="gene ID" value="B456_006G041800"/>
    </dbReference>
    <dbReference type="OMA" id="QCEESIR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052929">
        <property type="entry name" value="RNase_H-like_EbsB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074">
        <property type="entry name" value="BNAC02G40300D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074:SF61">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB33981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="15841" checksum="13B2B02841E7B484" modified="2015-04-29" version="1">MVHERKITSGRDLSHKIQSYLLELEGVREKKLTFTSARTQGQGGESMREIIQFDAAFDIINSRSTSGLVVRDQKGVIKASKSILHSNVSSPFVADACACLEATKLGIEMGLRSITIMGDLKTVTNKCQMTVRDKSIIGKIIKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S196</accession>
    <name>A0A0D2S196_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G235900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S196"/>
    <dbReference type="SMR" id="A0A0D2S196"/>
    <dbReference type="STRING" id="29730.A0A0D2S196"/>
    <dbReference type="Gramene" id="KJB38069">
        <property type="protein sequence ID" value="KJB38069"/>
        <property type="gene ID" value="B456_006G235900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38070">
        <property type="protein sequence ID" value="KJB38070"/>
        <property type="gene ID" value="B456_006G235900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800490"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPNINDR"/>
    <dbReference type="OrthoDB" id="581196at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB38069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="148" mass="16489" checksum="4D286C88D13BD04B" modified="2015-04-29" version="1">MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPSDSPFAGGVFLVNIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYEATARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S859</accession>
    <name>A0A0D2S859_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G230500</name>
        <name evidence="6" type="ORF">Gorai_001651</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB37916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588555.1"/>
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        <property type="entry name" value="Allene oxide cyclase-like"/>
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            <begin position="29"/>
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            <dbReference type="ARBA" id="ARBA00010746"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022525"/>
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        <source>
            <dbReference type="RuleBase" id="RU363099"/>
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    <sequence length="192" mass="20951" checksum="73E20061E546DDD9" modified="2015-04-29" version="1">MPKTFSKLSSSTFFFHFTLLFFSATSSGSFSNILSPKKFGLKREKLTHLHFYFHDIVSSRNPTAIPVASAASTNKSHTGFGVVMMADDPLTAAPDPNSKLVGKAQGIYASAAQDEVGLLMVMNLAFTEGKYNGSSLSLLGRNTVFSRVREMPLVGGSGLFRFARGYAQAKTHTLDLKTGNAVVEYNVYVFHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAU2</accession>
    <name>A0A0D2SAU2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G155000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
    <sequence length="2013" mass="218316" checksum="A1109617209C2C92" modified="2015-04-29" version="1">MHGCNSGSALLVNAEVDSMGGVVDGGVGIGVKTSPRRVAIEKAQAELRQEYDVREERRRELEFLEKGGNPLDFKFGNAASVSVQSTSLTDQQAEHFAISEAKGSFGLTASPHGDSVESSGRPGIPAVCEPNSADNLLLFHGENELPEGERKSMHPRKKNTVVPSEQSSQMGRTQNAKESEDSAIFRPYARRNRSKLNRDAARSSSTEMGQGRGGHGPSLPARVSSKDEKVLTNNQKDKNMPSVNIAKSATSNGNLASKVITSGNLLNMELDGGQAAEATTDQSKGDLSKSKVDATVPNEPVQVDVHKSAVNLASEEPDLVGGKEQAISTGFECPADSGANKAENETISNKLNGFGDAKRDGKNIRVEGQNSSAARGVKGLDSESSCTENSLSLDVNNDNDACINPKNVDSNGKPMEQTSEKEESLNLAVGELAKEKNEIVAADNVAIIWDAQTSKNQNHSLTDSIVKVEEEVRSELQNEVSCPSNKEVQQSSPPVSEADRKTNTVLGDNSNSKNENICASGLLGTMGNFICEIPERTLLGRTSTANTDVQTNMDGHVKVVDKAHEDSILEEARIIEAKRKRIAELSVGALPLENRRKSHWDFVLEEMAWLANDFAQERLWKMTAATQLCRRAAFTSRLKYEEQNQFWKLKRVALTLANAVMEFWHSAELLRNSKDRSLGPNNCGHDLVGSRANEVTENKNAELDMDIHEEQQEHPGKNNEFAIQAYAVRFLKYNSSPVPTLQAEAPATPDRISDSGITDISWNEHLTEESLFYSVPSGAMETYRRSIESYLVQTEKTGSSAQEEVETSAYDDGAEFGYGDFVYDEDEGETSTYYLPGAFEGRKSSKLNKKKRKNPMKSYPARPYEMDADLPYGSCAQQSVLIGKRPGSSLNVGPIPTKRVRTGSRQRVISPFGSAAAAGGLQAPMKTDASSGDTNSFQDDQSTLHGGFQMQKSNEVESIGDFERQLPYDCAETPTKPKKKKKAKNLLSAYDQGWQLESTVHSEQRDYSKKRSESHHFDSNGSSVLYGQQNAKKLKLMKQQPDNAFDINPSGSIPSPVGSQMSNMSNPNKIIRLIHGRDRGRKAKTLKMSAGEPGSGCPWSLFEDQALVVLVHDMGPNWELISDAINSTLQFKCIFRKPKECKERHKILMDRSGDGADSADDSGSSQPYPSTLPGIPKGSARQLFQRLQGPMEEDTLKSHFEKIIHIGKKQHYRRNQHDNQDPKQIVPVHNSHVIALSPVCPNKLNGGVLTPLDLCDATASSQDVLPLGNLASNTSGLAISNQGAAGSMLPASAANSSLQGSSGMVLGSNLASLSTPLNSSVRDGRYGVLRTSLPADEQHRMQQYNQMLSGRNVQQSNLSLPGAVSGSDRMVRVLSGNNLGMMCGINRSMPISRPGFQGMTSSAMLNSGSMLSSNLVGGMQNPVNMHSGTGSGQGNSMLRPRDTKHMMRPGHSPELQMQAQGNGQGISAFNGLNSAYPNQSTAPSVQSYPGHPQQQQQMPQQQSHALSNSHHPQHQGSNHASGPQQQAYAMRVAKERQMQQQRLMQQQQPQQQQQKQFTASSALMSHVQPQTQLPISSSLQNSSQIQSQASTQPVSLPAPSSPMTPMSLQHQQKHHLAPHGLGRNPQTGASGLNNQIGKQRQRQPQQQQQQFQQSGRHHPQQRQPPQSQQQTKLLKGVGRGNMLVHQNLSADPAHLNGLSMASSNQAAEKGEQIMHLMQGQGLYPGPGTGPVQQSKPLVSQPQQKLFSGATPPSTKQPQQMASHSDNSSQGQVSTVPSGHIPSAGNQCVLPASVGPNHQHLQLQSQPHQKKVNQNQSTVQRVLQQNRQVNSDPLSKPQAEPAQADQQPMNNASQMGTTTTAAVSEVGIDSANNTVQNVPSAGSQWKSSDPVYNPGMPTLATQVGSIGSPPLTNSAASVPLPSFNQGLGQRQLPGGLPLHGSKAGAQRPQLPQIQQSSTPAPSQQHYQPQEQLQQDLHNSPPQQLPLQQQSQQQTPHLQAVQGSLYHRPSNSKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBW7</accession>
    <name>A0A0D2SBW7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G006300</name>
        <name evidence="12" type="ORF">Gorai_017658</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0588880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBW7"/>
    <dbReference type="STRING" id="29730.A0A0D2SBW7"/>
    <dbReference type="Gramene" id="KJB39321">
        <property type="protein sequence ID" value="KJB39321"/>
        <property type="gene ID" value="B456_007G006300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0920">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000480">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000526">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF229">
        <property type="entry name" value="DEXH-BOX ATP-DEPENDENT RNA HELICASE DEXH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="308"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="564"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB39321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0588880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1196" mass="134441" checksum="46B847276ACD764A" modified="2015-04-29" version="1">MSCYSAIFQGYLRTTAMSLRPASLQLNNSPKILLKPCSFSFVPRTQSPGSFRRLHLRNGLVRCSKSGTAASSSRTIALDWRNVALPYSELQSSNYGRYAYQDVSGDDSDHEFGSPQSQSQMGASTLDNIDEWRWKLTMLLRNKDEQEVVSRERKDRRDFEQLSALATRMGLNSRQYAKVVVFSKLPLPNYRSDLDDKRPQREVVLPFGLQRDVDLHLKAYLSHKAMSSGRSLDKPLIRSNSGGIPAADEVPVNPEPFAQNSVALERILRRRSLQIRDKQQEWQESPEGQKMLEFRRSLPAYKERDALLNAISQNQVVVVSGETGCGKTTQLPQYILESEIEAARGASCSIICTQPRRISAMAVSERVAAERGEKLGESVGYKVRLEGMKGRDTRLLFCTTGILLRRLLVDRDLRGVSHVIVDEIHERGMNEDFLLIVLKDLLPRRPELRLILMSATLNAELFSSYYGGAPTIHIPGFTYPVRAHFLENILEMTGYRLTPYNQIDDYGQEKMWKMQKQAQSFKKRKSQLTSAVEDVLEDADFRGCSLRTRESLSCWNPDSIGFNLIEHVLCHIVRKERPGAILVFMTGWDDINSLKGQLQAHPLLGDPSKVLLLACHGSMPSSEQRLIFEKPEDGVRKIVLATNMAETSITINDVVFVVDCGKAKETSYDALNNTPCLLPSWISKAAARQRRGRAGRVQPGECYHLYPKCVYDTFADYQLPELLRTPLQSLCLQIKSLELGGITEFLSRALQPPELLSVQNAVEYLKIIGALDENENLTVLGRNLSMLPVEPKLGKMLILGAIFNCLDPIMTVVAGLSVRDPFLMPFDKKDLAETAKAQFAGQEYSDHIAVIRAYEGWKEAEREQSGYEYCWKNFLSAQTLKAIHSLRKQFFYLLKDAGLVDQNVENCNKWSHDEHLVRAVICAGLFPGICSVVNKEKSIAMKTMEDGQVLLHSNSVNAEVPKVPYPWLVFNEKVKVNAVFLRDSTGVSDSILLLFGGNISRGGLDGHLKMLGGYLEFFMKPALAVMYLSVKRELEELIQRKLLDPTLDMHSSNELLSAVRLLVSEDRCEGRFVFGRQVTLSSKKTATVKTPGKSEADNSKNHLQTVLTRAGHGPPTYKTKQLKNNQFRSTVIFNGLDFVGQPCSSKKLAEKDAAAQALLWLRGEDHSTSRDIDHASLLLKKSKSRRKTSVSDAKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBW8</accession>
    <name>A0A0D2SBW8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G119700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBW8"/>
    <dbReference type="STRING" id="29730.A0A0D2SBW8"/>
    <dbReference type="Gramene" id="KJB41769">
        <property type="protein sequence ID" value="KJB41769"/>
        <property type="gene ID" value="B456_007G119700"/>
    </dbReference>
    <dbReference type="OMA" id="QIESSHI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704:SF37">
        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB41769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="183" mass="21241" checksum="ACE3819D025B6BE1" modified="2015-04-29" version="1">MSTSAVEVSGKKVKSMWDKRLTEKFCDICIKEILKGNSPGTHFTKDGWLKIMTNFEKETGKGFSQRQLKNRWDALKKEWKAWKKFKGENTGLGWNLIKRTVDASDDWWESRLQVVSEAQKFQISSIDPEFEGKLDQMFMGIVATGDKAWAPSSGTLRTDFFEDVTNEIPEENEEENMRMMFTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SH81</accession>
    <name>A0A0D2SH81_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G101500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Vesicle trafficking protein that functions in the secretory pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the t-SNARE complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SH81"/>
    <dbReference type="STRING" id="29730.A0A0D2SH81"/>
    <dbReference type="Gramene" id="KJB41296">
        <property type="protein sequence ID" value="KJB41296"/>
        <property type="gene ID" value="B456_007G101500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802721"/>
    <dbReference type="eggNOG" id="ENOG502QS7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEVDRMI"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000037">
        <property type="entry name" value="Putative syntaxin-71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF264">
        <property type="entry name" value="SYNTAXIN-73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="173"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB41296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="267" mass="30176" checksum="08617FB12F5981A3" modified="2015-04-29" version="1">MTVIDLITRVDAICKKYDKYDIDKQKAVNVAGDDAFARLYGVVDSEIDAALQKSEAAATEKNRATAVAMNAEIRRTKARLLEELPKLQRLALKKVKGISKEELEARNDLVYSLKDRVDSIPDGSSTATKQSTGGWATSTSSTGIKFDSSSDERFTSEYFQQTEESDRFRQEYEMRRMRQDQGLEVIAEGLDTLKDMAHDMNEELDRQVPLMDEIDDKVDRATSDLKSTNVRLKDTVHKLRSSRNFCIDIILLCIILGIAAYLYNALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLU0</accession>
    <name>A0A0D2SLU0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G224800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLU0"/>
    <dbReference type="Gramene" id="KJB32110">
        <property type="protein sequence ID" value="KJB32110"/>
        <property type="gene ID" value="B456_005G224800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502T1KB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGSNVFI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251445" evidence="1">
        <location>
            <begin position="26"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB32110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="111" mass="11816" checksum="83C32010A00AD5B2" modified="2015-04-29" version="1">MGSNVFILLACFILLGFSSMEVSLAARNLQQVTTLPPFPRVPIPPLPNLTPILPPLPSVPIPPLPRVPIPPLPRLPIPPLPNLTPILPPLPSLPIPPLPSLPIPPLPPILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMW9</accession>
    <name>A0A0D2SMW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G309500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMW9"/>
    <dbReference type="Gramene" id="KJB45509">
        <property type="protein sequence ID" value="KJB45509"/>
        <property type="gene ID" value="B456_007G309500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLEPNCI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251888" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="440"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB45509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="57353" checksum="F9E2F56B22543CE5" modified="2015-04-29" version="1">MFYFSLGLLALGAGGVKGALPALGGDQFDHKDPKEAKALARYFNWLLLSTTLGACVGVTGIVYLTTEKHKWYWGFFISTVATFIGFTVLALGKPFYRLREPKMADSPIIRITQVIVVAINNSKLALPDSPDELYEIRKTENDFREEIISHTNQFRFLDKAAIVPKDSKTTPWTVCTVTQVEEVKILTRMLPILFSTVIMNTCLAQLQTFSVMQGNFMNRKIGNFNVPAASIPIIPLVFMSILVPIYEFFFVPFARKITKHPSGITQLQRVGVGLVLSAISMAIAGIVEVKRRDQAHRDIMKPISLFWLSFQYGIFGIADMFTLVGLLEFFYREAPIGMRSLSTSFTWLTLSFGYFLSTVFVNVINAITKRTSSSKQGWIHGLDLDSSHLNLFYWFLAILSCLNFLNYLYWASWYKYKTEEPDHSEPKPIDMTTEQLPMEEVPDPTEAKGEDLSTRPLVAEEEPEHTEAKAKDLSTGPLLVKEGSTVDGGVTEVHEGPSSVQTEDSKQQPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SP97</accession>
    <name>A0A0D2SP97_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G078600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">May function as somatic storage protein during early seedling development.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the APS1/VSP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SP97"/>
    <dbReference type="Gramene" id="KJB65053">
        <property type="protein sequence ID" value="KJB65053"/>
        <property type="gene ID" value="B456_010G078600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS0C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYEMSAV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07535">
        <property type="entry name" value="HAD_VSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014403">
        <property type="entry name" value="APS1/VSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284">
        <property type="entry name" value="ACID PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284:SF10">
        <property type="entry name" value="ACID PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002674">
        <property type="entry name" value="VSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267401" description="Acid phosphatase" evidence="4">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB65053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31074" checksum="3D704792F5CE9284" modified="2015-04-29" version="1">MASQPLTFLFLLLLTASVLESSTSFEPNIRLPTTATIVPRSDIDDDLYCASWQLAVETNNAGSWAAIPSRCVPFVRDYMTGQRYASDCEVVANYSLAYASTVKIASDGKDAWVFDVDETLLTNLPYYRDHGFGINGIEKNTHPDLSWLGRSEIFNESCWDEWVAEAKAPAIPSSLKLYNGLKQMRFKIFVLTGRSEHQRNDTRKNLELAGYTGWEGLILRGASDGGTPATIFKSERRSVLVNEGYRIHGNSGDQWSDLLGFAVAKRSFKLPNPMYYIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SU31</accession>
    <name>A0A0D2SU31_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G164100</name>
        <name evidence="3" type="ORF">Gorai_007949</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SU31"/>
    <dbReference type="Gramene" id="KJB66903">
        <property type="protein sequence ID" value="KJB66903"/>
        <property type="gene ID" value="B456_010G164100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773755"/>
    <dbReference type="eggNOG" id="ENOG502S15Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRECYEH"/>
    <dbReference type="OrthoDB" id="1930727at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37187:SF19">
        <property type="entry name" value="(RAPE) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37187">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0598173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="316" mass="33745" checksum="D64187CF1E4404A9" modified="2015-04-29" version="1">MPSGAKKRKAAKKKKEQAANNINPSTNNNPLGNDDPRSQDERDSDGGDAGSPASHDGHSHQHSFGQGGDEERSQSHLTEKSVEEAAKDAKSTERSGLDDVDVKIVKEWEPNKDLESTHVSIQHVDHDKSSSTSSNSSSDDESQAFEKKSNEETCNLGSDAASYSTEDKSATVLSEEVLTVAENNTLKNADSNSAVETVAVDNLVKNMSLVPEEVEFSAKSSVPDVVESGMKENEEKLLPSSNGASGVELEGVERKNFPSSGIPTAETSNVAEKNHASGPHGYPKKQPLVAPTPPPVRRTSWLSCCGLFEVFTGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUT0</accession>
    <name>A0A0D2SUT0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G046900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUT0"/>
    <dbReference type="STRING" id="29730.A0A0D2SUT0"/>
    <dbReference type="Gramene" id="KJB47904">
        <property type="protein sequence ID" value="KJB47904"/>
        <property type="gene ID" value="B456_008G046900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763046"/>
    <dbReference type="eggNOG" id="KOG4189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSHACTL"/>
    <dbReference type="OrthoDB" id="116883at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000005">
        <property type="entry name" value="Accelerated cell death 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF43">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB47904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="22606" checksum="96EFBBC0F1FF29C5" modified="2015-04-29" version="1">MANSENEKILRKMADAFKELAATVNSQTADMEVAPFSRACSFVSPLFGCLGIAFKFAEMDYVAKVGDLAEASKSIATLKVMLDRDIEGNCVRKAGSHTRNLLRVKRGLDMVRVLFEQILATEGDSLKDPASKAYAQVFAPHHGWAIRKAVAAGMYALPTKAQLMKKLNEDEASARIQMQHYVAASSSVILYIDKLFLSRELGIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVI6</accession>
    <name>A0A0D2SVI6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G345200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The PPC domain mediates interactions between AHL proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVI6"/>
    <dbReference type="STRING" id="29730.A0A0D2SVI6"/>
    <dbReference type="Gramene" id="KJB46031">
        <property type="protein sequence ID" value="KJB46031"/>
        <property type="gene ID" value="B456_007G345200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB46034">
        <property type="protein sequence ID" value="KJB46034"/>
        <property type="gene ID" value="B456_007G345200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVTT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039605">
        <property type="entry name" value="AHL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500:SF68">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31500">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="7">
        <location>
            <begin position="118"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB46031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="345" mass="36075" checksum="B583BAFBF4CD0205" modified="2015-04-29" version="1">MELNETQQHYFTSNNSNTVTATPSPANGFLLPNDGGGSHHMVYPHSVPSAVTSAMEPARRKRGRPRKYGTPEQAMAAKKTASLSSKVQREQQQQQQLGLGGGGRGSSKKPQLVALGNAGQGFTPHVVNVVAGEDVGQKLMMFIQQSKREVCILSASGTISNVSLRQPATSGGNIAYEGRFEIVSLSGSYVRNETGGRTGGLSVCLSSGDGQIIGGGVGGPLKAAGPVQVIVGMFTIDNKKYVSAGAKGEASGSKLPSPVGGTSISNIGFRATFETSGRNPIVGNDDHQSFGGSHFMMQPRGMHMAAQSTDWRIALDDRTGFELTGKTGHGAHQSPENGDYDQITG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZF7</accession>
    <name>A0A0D2SZF7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G121800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SZF7"/>
    <dbReference type="STRING" id="29730.A0A0D2SZF7"/>
    <dbReference type="Gramene" id="KJB49489">
        <property type="protein sequence ID" value="KJB49489"/>
        <property type="gene ID" value="B456_008G121800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763875"/>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:002723">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000180">
        <property type="entry name" value="serine/threonine-protein kinase STY46-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF62">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="135"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB49489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="414" mass="46615" checksum="03FE55B449F12858" modified="2015-04-29" version="1">MEDFRPSHSSSTKLVGQKVDSGGLYRLLQCASKGDKAGVIQELDKGVEPNGADYDRRTALHLAACEGWIEVVDLLLEKGADVNSLDRWGRTPLSDAHSFRHHEVCKILEARGGIDPVGMDSQAPCFEIDHSEVDMEEATRIGEGAYGEVFLVNWRGTEVAAKTIRSTIASNPKAKNTFLKELALWQQLRHPNIVQFLGVLKHSDRLIFLTEYLRNGSLYDILKKKGRLDTKTAISYALDIARGMNYLHQHNPHAIIHRDLTPRNVLQDEAGRLKVTDFGLSKIAQEKDSYGYKMTGGTGSYRYMAPEVYRRESYGKSVDVFSFALILHEMFQGGPSNRAETAEQIADKRAYEDSRPPLSSFLYPEPIKMLLKECWHKNPDCRPTFGEIISQLEVIEQDFQNEKAMKACCCCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T0R2</accession>
    <name>A0A0D2T0R2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G051100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T0R2"/>
    <dbReference type="Gramene" id="KJB48036">
        <property type="protein sequence ID" value="KJB48036"/>
        <property type="gene ID" value="B456_008G051100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HAKHAIS"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000056">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF81">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB48036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="495" mass="54723" checksum="1A94069A0D79003D" modified="2015-04-29" version="1">MAMDKYEAVFISTPSIGNLVPTVEFAHHLTRHDPRFSATLLIITVPERTIVNLYTQSLATAISHSHSHVNFIHLPTIQPPTPDQYQSSLGYTSLLIDKHKPHAKHAISTLMSTTSVAALFVDMFTTSMIDVAQDLGIPCYLFFASPASFLGFMLHLPALDTQLAVDFVDSDSQSGFIVPKDSAVELIVPTFSKPLPPSMLPSHVLKRNKDGYFCFLENARRYTETIGIVVNTFLELEPHAIESLSISGLPPVYPVGPILDHAGASRWHPDGAQQQDSIMEWLDQQPPSSVVFLCFGSMGSLEGPQLREIAIGLESSGYRFLWSIREPPKGKLDLPGEYTNVEAALPAGFLDRTAGLGIVCGWVQQVRVLSHQAIGGFVSHCGWNSILESVWHGVPIATWPVYAEQQMNAFELVKELGLGVEIRLDYREGSDLVVAEELERGLRRLMDGEDEVKAKVREMEAKSRMALMENGSSYKSLTSLIQEISCRIQGSEVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2Z2</accession>
    <name>A0A0D2T2Z2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G190000</name>
        <name evidence="8" type="ORF">Gorai_009944</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2Z2"/>
    <dbReference type="STRING" id="29730.A0A0D2T2Z2"/>
    <dbReference type="Gramene" id="KJB50854">
        <property type="protein sequence ID" value="KJB50854"/>
        <property type="gene ID" value="B456_008G190000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764611"/>
    <dbReference type="eggNOG" id="ENOG502QQE4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFQGVIV"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF133">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="318"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB50854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0592985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="530" mass="58378" checksum="E26435191B13B07D" modified="2015-04-29" version="1">MERLNLKHKLGDKWISTLASIWIQCTSGSLYTFSIYSPILKSTQRYDQSTLDTVSVFKDIGANCGVLSGFLYTFATPSNRRNAYFGGPCLVLAAGAIQCFMGYFLIWASVVGLIPRPPVVGMCFFVLLAAHAQTFFNTANVVTAVRNFPDYSGTAVGIMKGFVGLSGAILIQFYETIFHNKPTSYLLILALLPTINSLLLMWFVRIYDTKEQEEKKLLNAISCVALLLAAYLMAVIIVDHLFTFQLLVRIATFVVLLLLLSSPLCIVPSLRAREKDSSVIHQSLISEGQRSDQEMEVHDTRDSLEEDNLNLLQAMASVYFWILFFGMACGMGSGLATVNNLGQIGESLGYSNFETNTLVSLWSIWNFLGRFGAGYVSDHFLYVKGWARPLFMVLTLSSMSVGHAVIASGMPGALYAGSILVGVCYGSQWSLMPTIASEIFGVKHMGTIFNAITIASPVGSYIFSVRVVGFIYDKEAWGSGCSGTHCFMLSFLIMASATLLGSLAALALFFHTKNFYNQVILRRLLHSLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T3Z6</accession>
    <name>A0A0D2T3Z6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G106300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T3Z6"/>
    <dbReference type="Gramene" id="KJB49201">
        <property type="protein sequence ID" value="KJB49201"/>
        <property type="gene ID" value="B456_008G106300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SYWD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRNIPCS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB49201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="125" mass="13756" checksum="AA7EEDFA31482099" modified="2015-04-29" version="1">MGIGELSWKEGGKEKWSLVELTLLISSMVNSAATVFLNIPFTGSVATIIAPFCSFVSSLSSSMGNNTSSMVFSHSLTRFETRSVVKNGCFSTFWMKGNRNNPPVRLSYFFNIFANPTNSQPLLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T4C5</accession>
    <name>A0A0D2T4C5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-methionine-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G213400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T4C5"/>
    <dbReference type="SMR" id="A0A0D2T4C5"/>
    <dbReference type="STRING" id="29730.A0A0D2T4C5"/>
    <dbReference type="Gramene" id="KJB51364">
        <property type="protein sequence ID" value="KJB51364"/>
        <property type="gene ID" value="B456_008G213400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764866"/>
    <dbReference type="eggNOG" id="KOG1635">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYRCGRD"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000002">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050162">
        <property type="entry name" value="MsrA_MetSO_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42799:SF2">
        <property type="entry name" value="MITOCHONDRIAL PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="8">
        <location>
            <begin position="92"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="256" mass="28735" checksum="1E3FEB41FE0C3B8E" modified="2015-04-29" version="1">MLRSLALVATTSTSTISKPLLFSPSPKLTLFFSPFSLPFPQTKRSLSLHRSPMNILKSFGFGANNKPTPSMQNSAVAQGPDDDVPAPAQQFAQFGAGCFWGVELAFQRVPGVTKTEVGYTQGFRDNPSYEDVCSGTTNHNEVVRVQYDPKECSFDTLLDVFWARHDPTTLNRQGNDVGTQYRSGIYYYTPEQENAARESMEKQQKLLNRKIVTELLPAKKFYRAEKYHQQYLAKGGRFGFKQSAEKGCNDPIRCYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T695</accession>
    <name>A0A0D2T695_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine racemase</fullName>
            <ecNumber evidence="9">4.3.1.18</ecNumber>
            <ecNumber evidence="10">5.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">D-serine dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_008G246100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="9"/>
    <dbReference type="EC" id="5.1.1.18" evidence="10"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T695"/>
    <dbReference type="STRING" id="29730.A0A0D2T695"/>
    <dbReference type="Gramene" id="KJB52084">
        <property type="protein sequence ID" value="KJB52084"/>
        <property type="gene ID" value="B456_008G246100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765212"/>
    <dbReference type="eggNOG" id="KOG1251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030378">
        <property type="term" value="F:serine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018114">
        <property type="term" value="F:threonine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070179">
        <property type="term" value="P:D-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006563">
        <property type="term" value="P:L-serine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000007">
        <property type="entry name" value="L-threonine dehydratase catabolic TdcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050">
        <property type="entry name" value="SERINE / THREONINE RACEMASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43050:SF1">
        <property type="entry name" value="SERINE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="22"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB52084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="329" mass="35157" checksum="4ABFBDC5E3682D89" modified="2015-04-29" version="1">MEVNKEKYAADLSSIKEARARISSFINKTPLMTSESLDAISGRRLFFKCECFQKGGAFKFRGACNAIFSLDDQQAAKGVVTHSSGNHAAALALAAKLRGITSYIVIPKNAPQCKVQNVVRYGGQVIWSETTIKSREETATTVQQETGAALIHPYNDGRIISGQGTISLELLEQAPHIDTIIVPISGGGLISGVALAAKSINPAIRVLAAEPKGANDAAQSKAAGRIVTLPETNTVADGLRAFLGEFTWPIVRDLVDDVITVDDTEIIKAMRLCYEILKVAVEPSGAIGLAAVLSDSFRTNPAWKDCNQIGIILSGGNVDLEVLWNSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCY5</accession>
    <name>A0A0D2TCY5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G035400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCY5"/>
    <dbReference type="STRING" id="29730.A0A0D2TCY5"/>
    <dbReference type="Gramene" id="KJB54479">
        <property type="protein sequence ID" value="KJB54479"/>
        <property type="gene ID" value="B456_009G035400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768288"/>
    <dbReference type="eggNOG" id="KOG0134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIGFGRP"/>
    <dbReference type="OrthoDB" id="1663137at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016629">
        <property type="term" value="F:12-oxophytodienoate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
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    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000073">
        <property type="entry name" value="12-oxophytodienoate reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF112">
        <property type="entry name" value="12-OXOPHYTODIENOATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="7">
        <location>
            <begin position="18"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB54479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="402" mass="44761" checksum="901B800F03DFFC84" modified="2015-04-29" version="1">MEHGEKVKMADSQGTPTLFSPYKMGKFNLSHRVVLAPMTRCRALNGIPRPALAEYYTQRSTPGGFLITEGTLISDTGAGFPHVPGIYNEEQVEAWKMIVDAVHAKGGIIFCQLWHVGRASHTVYQPGGVAPISSTNKPISKRWRILMPDGSYGIYPKPRPLETSEIQEVVEHYHKAALNAIRAGFDGIEIHGAHGYLIDQFLKDGINDRTDEYGGSLANRCKFLMQIVQAVASAIGIDRVAIRMSPAIDHLDATDSNPLNLGLAVIERLNKLQLQLGSKLAYLHVTQPRYHAYGQTESGKHGNEDEEAYLLKELKRTYQGTFMCSGGFNRELGMQAVAEGDADLVSYGRLFISNPDLVLRLKVNAPLNRYIRKTFYTHDPVVGYTDYPFLNEEKGRQVQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJF2</accession>
    <name>A0A0D2TJF2_GOSRA</name>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G219300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJF2"/>
    <dbReference type="STRING" id="29730.A0A0D2TJF2"/>
    <dbReference type="Gramene" id="KJB43845">
        <property type="protein sequence ID" value="KJB43845"/>
        <property type="gene ID" value="B456_007G219300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803978"/>
    <dbReference type="eggNOG" id="KOG0273">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TITSCEM"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000001">
        <property type="entry name" value="F-box-like/WD repeat-containing protein TBL1XR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="LISH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB43845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="161" mass="18664" checksum="1D51EFC2D7787C6A" modified="2015-04-29" version="1">MTSITSVELNYLVFRYLQESGFTHSAFTLGYEAGINTCSIDGNLIPPGALIRFVQKGLQYLEMEANLSNSDVETDEDFSFLHPLDIITKDVNQLQQLVKERRKNRDKDRDREVEREYEGERGQVIEKEIQEKEKEHDKDRKKELADSDMVTNQEENDSSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKL1</accession>
    <name>A0A0D2TKL1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Knottin scorpion toxin-like domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G080900</name>
        <name evidence="3" type="ORF">Gorai_004377</name>
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    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKL1"/>
    <dbReference type="Gramene" id="KJB76263">
        <property type="protein sequence ID" value="KJB76263"/>
        <property type="gene ID" value="B456_012G080900"/>
    </dbReference>
    <dbReference type="OMA" id="CTQENCN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036292382" description="Knottin scorpion toxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB76263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0601191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8874" checksum="BFA5E8BD2FD55C75" modified="2015-04-29" version="1">MDAMKRPSFSFSAVFLLLLFLSSGNRVTMGQNSDCDLQSFASPGCNQDGCNNLCIQHFGKTGKFGPVYGVCFASAICMCRQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TP42</accession>
    <name>A0A0D2TP42_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G135400</name>
        <name evidence="12" type="ORF">Gorai_004751</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TP42"/>
    <dbReference type="STRING" id="29730.A0A0D2TP42"/>
    <dbReference type="Gramene" id="KJB77394">
        <property type="protein sequence ID" value="KJB77394"/>
        <property type="gene ID" value="B456_012G135400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77395">
        <property type="protein sequence ID" value="KJB77395"/>
        <property type="gene ID" value="B456_012G135400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77396">
        <property type="protein sequence ID" value="KJB77396"/>
        <property type="gene ID" value="B456_012G135400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77397">
        <property type="protein sequence ID" value="KJB77397"/>
        <property type="gene ID" value="B456_012G135400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77398">
        <property type="protein sequence ID" value="KJB77398"/>
        <property type="gene ID" value="B456_012G135400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780507"/>
    <dbReference type="eggNOG" id="ENOG502QVVU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHHFRDC"/>
    <dbReference type="OrthoDB" id="414641at2759"/>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF20">
        <property type="entry name" value="FAD SYNTHETASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAD synthetase" evidence="10">
        <location>
            <begin position="144"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB77398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0601577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="419" mass="46477" checksum="9289D7B17E8B2C82" modified="2015-04-29" version="1">MPQKPYPLLLTVTSSSSVRCSFAAKHILHFVYLFILTIITIKVRQKMLACGGSRISHQNLGSRFCSTGIFHLSSFTVKPPSYATATVAAIVDNNSHNPRFHPRFVSSSSLQSKSPGDIPFPPVSFSQREDEHEKPSEALSSVAGGIVALGKFDALHIGHRELAIQASKVGTPYLLSFVGMAEVLGWDPRPPVVAQCDRERVLSSWAPYCGNVAPKEFQVQFMSVRHLSPRQFVEKLARELGVCGVVAGENYRFGYKAAGDASELVRLCDEFGMGAYIINSVMDRHQDARNMNRLDLKDRGQVSSTRVRQALAEGDMKYVSELLGRPHRLLLTIKDWESLTSTSSTQRMSAPRSSLLNLPPKDGFYENCSLLFGEQNAVTCRVSIDTSHIHLEMDRVDFCDNDYSQKSQVLGIEFGELKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQB5</accession>
    <name>A0A0D2TQB5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_012G158300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQB5"/>
    <dbReference type="STRING" id="29730.A0A0D2TQB5"/>
    <dbReference type="Gramene" id="KJB77798">
        <property type="protein sequence ID" value="KJB77798"/>
        <property type="gene ID" value="B456_012G158300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780570"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANHTTVM"/>
    <dbReference type="OrthoDB" id="10051137at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF2">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE 4, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="165"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB77798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="378" mass="43414" checksum="05D6E27B68BA22A3" modified="2015-04-29" version="1">MNSSEGKLKSSSSELDLDRPNIEDYLPSGSSIQEPHGKLRLRDLLDISPALTEAAGAIVDDSFTRCFKSNPPEPWNWNVYLFPLWCCGVVFRYLILFPMRALVLTIGWIIFLSCFIPVHFLLKGNDNLRKKMERALVELICSFFVASWTGVVKYHGPRPSMRPKQVFVANHTSMIDFIILEQMTAFAVIMQKHPGWVGLLQSTILESVGCIWFNRSEAKDREIVTRKLREHSQGADNNPLLIFPEGTCVNNQYSVMFKKGAFELGCTVCPIAIKYNKIFVDAFWNSRKQSFTMHLLQLMTSWAVVCDVWYLEPQNLRPGETPIEFAERIRDIISVRAGLKKVPWDGYLKYSRPSPKHRERKQQSFAESVLRGLELEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSI7</accession>
    <name>A0A0D2TSI7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">procollagen-proline 4-dioxygenase</fullName>
            <ecNumber evidence="4">1.14.11.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_009G191400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:18945"/>
            <dbReference type="Rhea" id="RHEA-COMP:11676"/>
            <dbReference type="Rhea" id="RHEA-COMP:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:61965"/>
            <dbReference type="EC" id="1.14.11.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the P4HA family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSI7"/>
    <dbReference type="STRING" id="29730.A0A0D2TSI7"/>
    <dbReference type="Gramene" id="KJB58041">
        <property type="protein sequence ID" value="KJB58041"/>
        <property type="gene ID" value="B456_009G191400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58042">
        <property type="protein sequence ID" value="KJB58042"/>
        <property type="gene ID" value="B456_009G191400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58043">
        <property type="protein sequence ID" value="KJB58043"/>
        <property type="gene ID" value="B456_009G191400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768940"/>
    <dbReference type="eggNOG" id="KOG1591">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000002">
        <property type="entry name" value="Prolyl 4-hydroxylase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF169">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="17">
        <location>
            <begin position="159"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB58041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="287" mass="32495" checksum="C24FA88AF94F8C68" modified="2015-04-29" version="1">MAKLRHSRLQAKKLSTVTLVLSMLFMLTVVLLMLLGLGIFSLPINGDDSPPNDLTSYRRMASERGKGLGKRGEQWTEVLSWEPRAFLYHNFLSREECEYLINLAKPYMKKSTVVDSKTGQSKDSRVRTSSGMFLRRGQDKIIMDIEKRIADYTFIPVENGEGLQVLHYEVEQKYDAHFDYFLDEINTKNGGQRMATVLMYLSDVEEGGETIFPAAKGNVSAVPWWNELSECGKKGLAVKPKMGDALLFWSMRPDATLDPSSLHGGCPVISGNKWSSTKWLHVEEYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSQ8</accession>
    <name>A0A0D2TSQ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pectate lyase superfamily protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G004800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSQ8"/>
    <dbReference type="STRING" id="29730.A0A0D2TSQ8"/>
    <dbReference type="Gramene" id="KJB78513">
        <property type="protein sequence ID" value="KJB78513"/>
        <property type="gene ID" value="B456_013G004800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRPESCI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265176" description="Pectate lyase superfamily protein domain-containing protein" evidence="9">
        <location>
            <begin position="27"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB78513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="40741" checksum="4B6A6990CA9E48CE" modified="2015-04-29" version="1">MMNLTRPSHSILLILFFMLAINSTSALTKYNVLNFGAKPNGKTDSTKAFLMAWKAACASADSTIIYVPKGRYLLGSMAFQGGCKSPQIIFRIDGTLVAPQDYRVLGKSTDWLSFQGVNGVSILGGALDAKGPSLWACKASHSNCPSGATTLSFTNSKNIRIRSLLSLNSQMFHIVINGCENVNVQGVRIIAAGNSPNTDGIHVQLSKNVNIIKCSIKTGDDCISIGPGTKNLWIEQITCGPGYGISIGSLAKDLKEEGVQNVTSWARPSTGFVQGVRFMDSLMRNVQNPIVIDQNYCPHNLNCPNQVSGIKIKDIIYEGIRGTSSTEVAIKFDCSPKNPCTGIRLQNVNLSYLNKPAQSSCSNVRGKALNLVRPESCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZT2</accession>
    <name>A0A0D2TZT2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="5 12">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G407400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="5 12"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZT2"/>
    <dbReference type="STRING" id="29730.A0A0D2TZT2"/>
    <dbReference type="Gramene" id="KJB62229">
        <property type="protein sequence ID" value="KJB62229"/>
        <property type="gene ID" value="B456_009G407400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766717"/>
    <dbReference type="eggNOG" id="KOG1557">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGSCHAY"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000068">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="8 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0702">S-nitrosylation</keyword>
    <keyword evidence="11" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB62229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="358" mass="38637" checksum="9CAFB81E3E4CDE05" modified="2015-04-29" version="1">MSCFISKYADELAKNAAYIGTPGKGILAADESTGTIGKRLSSINVENIEENRRALRELLFTAPGALQYLSGVILFEETLYQKTASGKPFVDVLKEGGVLPGIKVDKGTVELNGTNGETFTQGLDGLAQRCQKYYEAGARFAKWRAVLKISANEPTELAVQENANGLAMYAAICQQCGLVPIVEPEILVDGSHDIQKCAAVTERVLAACYKALNDHHVMLEGTLLKPNMVTPGSDSPKVAPDVIAEYTVRALQRTVPAAVPAIVFLSGGQSEEEATLNLNAMNKLQTKKPWSLSFSFGRALQQSTLKTWAGKEENVKKAQDALLVRCKANSEATLGTYKGDAELCEGAAESLHVKDYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5U6</accession>
    <name>A0A0D2U5U6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YLP motif-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G191000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5U6"/>
    <dbReference type="STRING" id="29730.A0A0D2U5U6"/>
    <dbReference type="Gramene" id="KJB50875">
        <property type="protein sequence ID" value="KJB50875"/>
        <property type="gene ID" value="B456_008G191000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764621"/>
    <dbReference type="eggNOG" id="KOG2400">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032204">
        <property type="term" value="P:regulation of telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000978">
        <property type="entry name" value="YLP motif-containing protein 1 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026314">
        <property type="entry name" value="YLP_motif_con_p1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413">
        <property type="entry name" value="YLP MOTIF CONTAINING PROTEIN NUCLEAR PROTEIN ZAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13413:SF0">
        <property type="entry name" value="YLP MOTIF-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="307"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="734" mass="82483" checksum="C56C179D4817B86A" modified="2015-04-29" version="1">MDQYYHHHQPHSQWRQPPPPQQPSPCPVCSIPHFPFCPPYPPYHHQNPNYPQHPNYARPGFDPFQPPAPPPPPPPPQPAPALPLPPPPYINGFADPRSWHTNPNYGYDYATAGGGDIDRSYKRPRIEEGCSGPARILTEDERRLKLIRDHGAASFSGFNQENKSLHNNINNNNNVNLMPPRSSEMYNIEDSLNNYTDYYGNNNYNYNQPQQIQHTDSVPTAVNHWQGYEQRLGGYLPHPGGNHMSQPPPPPLPASPPPPLPVEAYSSSSNSSVSLFPIGVSSSVTAHSTYPVVTEPYYQNKPPPHAFHREDPQVTHRTSSVKYAANPQKELSSDKAKFVDASELFKMPHRASRPDHIVIILRGLPGSGKSYLAKMLRDLEVENGGDAPRIHSMDDYFMTEVEKDEEIEVSKSSSSVRSKKTVKKMVMEYCYEPEMEEAYRESMLKAFRRTLEDGIFSFVIVDDRNLRVADFAQFWAIGKRSGYEVYVLEATYKDPVGCAARNVHGFTLDDIQQMAGQWEEAPSLYLQLDIKSLFHGDDLKESGIQEVDMDMEDGDREEGLSGQEEQKTEKVNLPTLGDHVPEDSSKDEKRWDAEGDYLVEVKELSRSKWSNNLDEDETEGSEAIKGNLNALSGLIQAYGNKGKSVRWSDQGGDTGFLIGAAKKAKMLSLVIGPGAGYNLKSNPLPKEESHTSNSIGNSKKQSSFQERLRAEHESFKAVFDRKKRIGGLDLDEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U913</accession>
    <name>A0A0D2U913_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="5">HMG-CoA synthase</shortName>
            <ecNumber evidence="5">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G243100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="5"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U913"/>
    <dbReference type="STRING" id="29730.A0A0D2U913"/>
    <dbReference type="Gramene" id="KJB52035">
        <property type="protein sequence ID" value="KJB52035"/>
        <property type="gene ID" value="B456_008G243100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765184"/>
    <dbReference type="eggNOG" id="KOG1393">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVESSTW"/>
    <dbReference type="OrthoDB" id="1269963at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00102"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000590">
        <property type="entry name" value="HMG_CoA_synt_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01226">
        <property type="entry name" value="HMG_COA_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="5" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxymethylglutaryl-coenzyme A synthase C-terminal" evidence="7">
        <location>
            <begin position="175"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR610122-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB52035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="465" mass="51479" checksum="86F04E928A525B4E" modified="2015-04-29" version="1">MAKNVGILAMDIYFPPTFVQQETLEAHDGVSKGKYTIGLGQDCLAFCTEVEDVISMSLTVVTSLLEKYKIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKCGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGIVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKFRGSHMSHAYDFYKPNLASEYPVVDGKLSQTCYLMALDTCYKYFCHKYEKQEGKQFSLSDADYFVFHSPYNKLVQKSFARLVFNDFVRNASSVDDIAKEKLAPFSTLTGDESYQSRDLEKASQQVSKPLYDAKVQPTTLIPKQVGNMYTASLYAAFASLLHSKNSELAGKRVILFSYGSGLTATMFSLRLHEGQHPFSLSNIATVMNIAGKLKSRHEFAPEKFVETMHLMEHRYGAKDFVTSKDCSLLSPGTYYLTEVDSKYRRFYAKKDGNCTGNENGSVVNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE43</accession>
    <name>A0A0D2UE43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G153500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE43"/>
    <dbReference type="STRING" id="29730.A0A0D2UE43"/>
    <dbReference type="Gramene" id="KJB66331">
        <property type="protein sequence ID" value="KJB66331"/>
        <property type="gene ID" value="B456_010G153500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774490"/>
    <dbReference type="eggNOG" id="KOG1686">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYFPWYS"/>
    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_bL21_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB66331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="28686" checksum="A42B1F8D4AB44D13" modified="2015-04-29" version="1">MAHRRCLHSALLHATALISLKKSPSLSIVKALTSKPNPGITTSNLEPSWFIPWSYIRHFSSRKSDDSENEAEMEESSDGEGESDEMASDMVRDYSPEEKEAEAAAIGYKVVGPLQRSDRVFKDYEPVFAVVQIGSHQFKVSNGDSIFTERLKFCEVNDKLILNKVLLLGSPTQTIIGRPILPDAAVHAVVEEHALDAKVIIFKKKRRKNYRRTKGHRQELTKLRITAIQGIEKPEIKTDGKPLKAAVKKPEKIAATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ34</accession>
    <name>A0A0D2UJ34_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G099800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ34"/>
    <dbReference type="STRING" id="29730.A0A0D2UJ34"/>
    <dbReference type="Gramene" id="KJB55859">
        <property type="protein sequence ID" value="KJB55859"/>
        <property type="gene ID" value="B456_009G099800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB55860">
        <property type="protein sequence ID" value="KJB55860"/>
        <property type="gene ID" value="B456_009G099800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769616"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23144">
        <property type="entry name" value="RING-HC_XBAT31-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056760">
        <property type="entry name" value="RING_XB3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24921">
        <property type="entry name" value="RING_XB3-XBAT31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 11" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="157"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="11">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="321"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB55860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="445" mass="47943" checksum="8D5B9DBF02941513" modified="2015-04-29" version="1">MGQGLSCGASQENVLFSAVQGGDLETVEALLRRESNLLHHTTVYDRHSALHIAAAYGQIEILAMLLEKSVNPDVVNRQKQTPLMLAAMHGNISCVKKLIEAGANILMFDSIHGRTCLHYAAYYGHSDCLQAILSAAQSSPVAVSWGYARFVNIRDAKGATSLHLAARQRRPDCVHILLDNGALVCASTGGYGCPGSTPLHLAARGGSLDCIRKLLAWGADRLQRDASGRIPYVVALKHKHGACAALLNPSSAEPIVWPAPLKFISELNEEAKTLLEQALMDANREREKNILKGTAYSIPSPSQSDSGLDDNISEASDTELCCICFEQICTIEVQDCGHQMCAQCTLALCCHNKPNPTTASLTPPACPFCRSPIVRLVVAKIKNHDDVDHDIGDVSSSKLRKTRKSRNFSEGSSSFKSLSAVGSFSKISGRGSGRIAAENEWIDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULC9</accession>
    <name>A0A0D2ULC9_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G134600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="KJB56750">
        <property type="protein sequence ID" value="KJB56750"/>
        <property type="gene ID" value="B456_009G134600"/>
    </dbReference>
    <dbReference type="OMA" id="AHEMVIH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35737">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35737:SF1">
        <property type="entry name" value="CRYPTIC LOCI REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB56750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9274" checksum="B4BCC20F72DF14C1" modified="2015-04-29" version="1">MQEKALDFQFQQQERRKSREKEEEKGIASFSGSENIDKDKKDNDFGSLVDELLLLTEAHEMVIHDVSNLCDIAEAVCDAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTW3</accession>
    <name>A0A0D2UTW3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G156900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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        </lineage>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB72074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_011G156900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1959">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Golgi alpha-mannosidase II"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
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    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050843">
        <property type="entry name" value="Glycosyl_Hydrlase_38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048534">
        <property type="entry name" value="Man2a1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11607:SF60">
        <property type="entry name" value="ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21260">
        <property type="entry name" value="Laman-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Lysosomal alpha-mannosidase-like central" evidence="3">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 38 C-terminal" evidence="2">
        <location>
            <begin position="124"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB72074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="214" mass="24256" checksum="4220670C67EE082A" modified="2015-04-29" version="1">MIHRHDIESKYWICVYWWLRIWKASLTCTCMRVVVKDSEGREIESQLIPLSNSTLCIRSQYIKAYLGKKPREIAKYWVAFSVLVPPLGFSTYIVATTKETEGRSPTISTMNTYEASENNTIEVGQGSLKLLYSADEGKLTRYVNTRNSVTAFAEKSYGYYSGNDGTDKDPQASGAYVFRPNGTFSIKSENQTPLTVVRGPLLDEVYQQLHFSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UW41</accession>
    <name>A0A0D2UW41_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G300900</name>
        <name evidence="2" type="ORF">Gorai_013025</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36482">
        <property type="entry name" value="OSJNBA0024J22.15 PROTEIN"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
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        <property type="gene ID" value="B456_011G229300"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="238" mass="25620" checksum="39188A6E679992AB" modified="2015-04-29" version="1">MAEVTKRYAVVTGGNKGIGLEICKQVASKGTMVVLTARDEKRGLEAVEKLKDLGLSGNVVFHQLDVADPASVASLVDFVKTQFGKVDILVNNAGIGGVKGDFEALRAAAFGKVNVSNEWAKAVLSDAGNLTEDKVDEILSQYMKDFKEGSLQGKGWPAFMSAYILSKAAMNAYTRILAKKYINFIINCVCPGFVKTDINFNSGIISVEEGAESPVRLALLPNNGPSGLFFVRKEESEF</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Romanel E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Plant_NBS-LRR"/>
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        <property type="entry name" value="AND NB-ARC DOMAINS-CONTAINING DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0611">Plant defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="19678" checksum="24B2FAD3C7DE8847" modified="2015-04-29" version="1">MEYVQPVLGIANCLGTPACKYLQYLRKLNDYVRNFKRMRDELICKMEDTELQLKEELLRPLGKIPKKRVENWLKAVKEMIKEAQVVENKVSNGRYLCRACNGKLVDEKTREMKEFLDNAPNASEGLAMDGPSAGLLLPTSELVGEEAVRNEIWACLMQEEVSKIGVRGMGIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UZP3</accession>
    <name>A0A0D2UZP3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indole-3-acetic acid-amido synthetase GH3.17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G387200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAA-amido conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UZP3"/>
    <dbReference type="Gramene" id="KJB61865">
        <property type="protein sequence ID" value="KJB61865"/>
        <property type="gene ID" value="B456_009G387200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPMU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRCIKFT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF95">
        <property type="entry name" value="INDOLE-3-ACETIC ACID-AMIDO SYNTHETASE GH3.17-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH3 middle" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="4">
        <location>
            <begin position="106"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="26854" checksum="63E89A6B91505D6C" modified="2015-04-29" version="1">MAYFEFLPVDKDWEEKARESNLDGVSSQWLSEMTNVNGNVEPVDFANVKLGQYYEVVVTTLTGLYRYRVGDVLKLTGFHNNSLQFQFVERRNTVLSIDMDKPSEADLLKAIRNAKRHREPLGFVLMTFSSYAETSSIPGRYVLFWELKFKERNRCLKLDAKIMEQCCSIEEESLDFTYKCLREANKIAALELRVVKHGTFDAVMDFYVSKGASINQYKTPSCIQSEEAVMPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V687</accession>
    <name>A0A0D2V687_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G169100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V687"/>
    <dbReference type="Gramene" id="KJB77941">
        <property type="protein sequence ID" value="KJB77941"/>
        <property type="gene ID" value="B456_012G169100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB77941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="150" mass="17294" checksum="401006678173146E" modified="2015-04-29" version="1">MAAHSGIIFFKELTDTDVKKRLVVPKEYQDFFLPSYGRLPAKIKLMYDGKIWEVKCTVRTKGFLRPVLTVGWKMFVVANELKVGDRITMYKDEDGFSHYMVEVEKPPAGNQHGTLPNSPAPSFIHHEPDETTVEYRREVPKNTTSLILHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA09</accession>
    <name>A0A0D2VA09_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="14">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_013G033600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the minichromosome maintenance (MCM) complex, a heterotetramer composed of MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7. Interacts with ETG1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="14"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VA09"/>
    <dbReference type="STRING" id="29730.A0A0D2VA09"/>
    <dbReference type="Gramene" id="KJB79104">
        <property type="protein sequence ID" value="KJB79104"/>
        <property type="gene ID" value="B456_013G033600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783654"/>
    <dbReference type="eggNOG" id="KOG0478">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFFKCNV"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000347">
        <property type="term" value="C:THO complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="16">
        <location>
            <begin position="429"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00064407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB79104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="839" mass="92900" checksum="35732EEA52DEF2E1" modified="2015-04-29" version="1">MASGSSPSNFNNGPSSPDDSFSSPIANTSSPAHRRRRGRRQASTPSSAAGTPPPNPSRFANSASTPTPARSTRRGRRPGPAKSTSPAVAATPSSTDDFSMPSSEGGEDMEEATPTFVWGTNISVQDVKNAIQMFIKHFRDPQELSNDIYGEGKYTRLIHRVLEVEGEWIDVDAHDVFNYDSDLYNKMMRYPLEVLAIFDIVLMDIVSVINPLFDKHVQVRIHNLKSSTSMRNLNPSDIEKMVSLKGMVIRCSSIIPEIREAVFRCIVCGYHSEPVVVDRGRISEPTSCLKQECLAKNSMALVHNRCRFADKQIVRLQETPDEIPEGGTPHTVSLLMHDKLVDAGKPGDRVEVTGIYRAMSVRVGPTQRTVKSLFKTYIDCLHIKKTDKSRMTAEDPMEVDKGSQRVDDDVQFDEDKVEELKELSKQPDIYERLTRSLAPNIWELDDVKKGLLCQLFGGNALKLLSGASFRGDINILLVGDPGTSKSQLLQYIHKLAPRGIYTSGRGSSAVGLTAYVAKDPETGETVLESGALVLSDRGICCIDEFDKMSDNARSMLHEVMEQQTVSIAKAGIIASLNARTSVLACANPSGSRYNPRLSVIDNIHLPPTLLSRFDLIYLILDKADEQTDRRLAKHIVSLHFEDTEIAEHDVIDLATLTAYVSYARKNIHPKLSDEAAEELTRGYVEMRKRGNFPGSSKKVITATPRQIESLIRLSEALARIRFSETVEMRDVTEAFRLLEVAMQQSATDHSTGTIDMDLITTGVSASERMRRESVLSATRNVIMDKLQLGGPSMRLLELLDEMKKQNSGSEIHLHDLRTAVATLASEGFVVLHGDSVKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI56</accession>
    <name>A0A0D2VI56_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF538 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G208000</name>
        <name evidence="3" type="ORF">Gorai_003419</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0603268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI56"/>
    <dbReference type="STRING" id="29730.A0A0D2VI56"/>
    <dbReference type="Gramene" id="KJB82664">
        <property type="protein sequence ID" value="KJB82664"/>
        <property type="gene ID" value="B456_013G208000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783545"/>
    <dbReference type="eggNOG" id="ENOG502RYFH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYTGDEI"/>
    <dbReference type="OrthoDB" id="1878965at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.240.10">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036758">
        <property type="entry name" value="At5g01610-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007493">
        <property type="entry name" value="DUF538"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676:SF10">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31676">
        <property type="entry name" value="T31J12.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04398">
        <property type="entry name" value="DUF538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141562">
        <property type="entry name" value="At5g01610-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0603268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18505" checksum="7757539F82E9D7F0" modified="2015-04-29" version="1">MSLVTEEIKASASEIYHGDEICQEKSKFLLEEVGMPRGLLPLRDIEECGYVKDTGFVWLKQKKSITHKFEKIGKLVSYATEVTAVVEKGKIKKLTGVKTKELLVWITLSDIQVDDPPTGKITFKTPSGLFRTFPVSAFEIEGEQVKGSKGKDEEKQVNGAVEVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKX3</accession>
    <name>A0A0D2VKX3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Patatin</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G105000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Lipolytic acyl hydrolase (LAH).</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the patatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKX3"/>
    <dbReference type="Gramene" id="KJB71085">
        <property type="protein sequence ID" value="KJB71085"/>
        <property type="gene ID" value="B456_011G105000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0513">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EGMKNMD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1090.10:FF:000005">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176:SF99">
        <property type="entry name" value="PATATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32176">
        <property type="entry name" value="XYLOSE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 6 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="6">
        <location>
            <begin position="18"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="6">
        <location>
            <begin position="172"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB71085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="356" mass="39166" checksum="1859A6D3AFE4A920" modified="2015-04-29" version="1" fragment="single">ELDGPNARIADYFDLIAGTSTGGLIATTLTTPNQQSRPSFAAKDISNFYLEHSPKIFPQHSRFNFLASMGNSIKATFSGPKYDGKYLRSLTNQLLQDTTLKQTLTNVLIPAFDIKLLQPVIFSTNDAKSDVAKNARLADVCMSTSAAPTYLPAHYFETKDADGKTRTFDLIDGGVAANNPTLLAINQITKDMWKEKSEIVGNEAIDCRRMLVLSLGAGAAKHEEKYNAAAASKWGRIDWLYNGGKTPIIDVFFDASSDMVDFHTATLFHSFQSECNYLRIQDDTLTGDASSVDIATEKNLKNLVQIGAKLLKKPVSRVNWVTGKYEAVEGESSTNEEALVDFAKKLSQERKLRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLA3</accession>
    <name>A0A0D2VLA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 19a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_N001700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLA3"/>
    <dbReference type="STRING" id="29730.A0A0D2VLA3"/>
    <dbReference type="Gramene" id="KJB84067">
        <property type="protein sequence ID" value="KJB84067"/>
        <property type="gene ID" value="B456_N001700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB84069">
        <property type="protein sequence ID" value="KJB84069"/>
        <property type="gene ID" value="B456_N001700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB84070">
        <property type="protein sequence ID" value="KJB84070"/>
        <property type="gene ID" value="B456_N001700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R8JR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MDHESKN"/>
    <dbReference type="OrthoDB" id="1920814at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019403">
        <property type="entry name" value="Mediator_Med19_met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536">
        <property type="entry name" value="LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22536:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="99"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB84069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="24266" checksum="44996D06D571F66E" modified="2015-04-29" version="1">MDAGGNKFGGGPRELSGVVDLISRYKLLPHHDFFCKRPLPLSIADTHYLHNVAGDTEIRKGEGMQLDQLNQNTSHNRDTNARIQPFDFDILKEAFQLRETTPVELPPTEKGMPTIAGKSKGEVKDKERKHKKHKDRDKEKDKEHKKHKHCHKDKDRSKDKDKEKKKDRSGHHGSGADHLKKHHEKKRKHDGDEVRNDINRHKKSKSKLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLM1</accession>
    <name>A0A0D2VLM1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_N012900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204151">
        <property type="protein sequence ID" value="KJB84244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLM1"/>
    <dbReference type="STRING" id="29730.A0A0D2VLM1"/>
    <dbReference type="Gramene" id="KJB84244">
        <property type="protein sequence ID" value="KJB84244"/>
        <property type="gene ID" value="B456_N012900"/>
    </dbReference>
    <dbReference type="OMA" id="DSNGATC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009717">
        <property type="term" value="P:isoflavonoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000213">
        <property type="entry name" value="Coniferyl alcohol 9-O-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="4">
        <location>
            <begin position="22"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB84244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="104" mass="11812" checksum="70E8DFB9846E19A7" modified="2015-04-29" version="1">MNMGNANGEHAIEALQAQAHIWRHAFNFVSFMSLKCALDLGILDIIHDHGKPMTITELVSALQMLNPAKACDIYRLMRILVHSDFFARQKLDNDAQEEVLTPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LTB9</accession>
    <name>A0A0D2LTB9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G014900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LTB9"/>
    <dbReference type="SMR" id="A0A0D2LTB9"/>
    <dbReference type="STRING" id="29730.A0A0D2LTB9"/>
    <dbReference type="Gramene" id="KJB07307">
        <property type="protein sequence ID" value="KJB07307"/>
        <property type="gene ID" value="B456_001G014900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770230"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEAWNSN"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF107">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB07307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="88" mass="9856" checksum="C11DDE2C9627C0AD" modified="2015-04-29" version="1">MGLVEDFQEYANKAKTLPPSTKDADKLILYGLYKQAMVGNVNTDRPGMLSPTDRAKWDAWKAVEGKTKEQAMTEYIAKVKEFLGQSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LX73</accession>
    <name>A0A0D2LX73_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
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        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
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        <text evidence="4">Belongs to the glycosyl hydrolase 18 family.</text>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUH4"/>
    <dbReference type="STRING" id="29730.A0A0D2MUH4"/>
    <dbReference type="Gramene" id="KJB22737">
        <property type="protein sequence ID" value="KJB22737"/>
        <property type="gene ID" value="B456_004G063500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790549"/>
    <dbReference type="eggNOG" id="KOG0765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPSGILM"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000148">
        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080:SF3">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46080">
        <property type="entry name" value="MITOCHONDRIAL SUBSTRATE CARRIER FAMILY PROTEIN J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="122"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="230"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB22737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="34596" checksum="D21E5D7C9D589E94" modified="2015-04-29" version="1">MEASNSRMQTFGQTEINWDKLDKTKFYVVGAGIFTGVTVALYPVSVVKTRLQVASKDTAERSAFSVIRGILKTDGIPGLYRGFGTVITGAIPARVIFLTALETTKVAAFSMVEPFKFSEPTQAAIANGIAGMTASLFAQAVFVPIDVISQKLMVQGYSGHAKYNGGLDVARKVLKSYGIRGLYRGFGLSVMTYSPSSAVWWASYGSSQRVIWRFLGQGTDLKEVAPSLSTIVAVQAAGGIIAGATASCITTPLDTIKTRLQVMGHEKRPSTRQVIKNLIADDGCKGFYRGLGPRFFSMSAWGTSMILAYEYLKRLCVKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MXT7</accession>
    <name>A0A0D2MXT7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G133800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MXT7"/>
    <dbReference type="STRING" id="29730.A0A0D2MXT7"/>
    <dbReference type="Gramene" id="KJB24227">
        <property type="protein sequence ID" value="KJB24227"/>
        <property type="gene ID" value="B456_004G133800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791351"/>
    <dbReference type="eggNOG" id="ENOG502QTDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEYARPN"/>
    <dbReference type="OrthoDB" id="785956at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051758">
        <property type="entry name" value="ERF/AP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657:SF20">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB24227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="298" mass="33304" checksum="A282F98E5F55F3AD" modified="2015-04-29" version="1">MQEINHPLGFNDIVNIGSSLSQLILSGGSNTLDSIFSHCAPSTTTTSTAITTNCIYEPIGSSVYLRQRELLQKFSQENNGNASFSCNSLMNRIPSYPNPASTSNFYLSPEKKKQYRGVRQRHWGKWVAEIRLPQNRMRIWLGTYETAEAAAYAYDRAAYKLRGEYARLNFENIKDPSKLGFGDGARLSALKNSVDAKIQAICQKVKRERAKKKAKKDRPAEAEKTVKVTESCSSSSSLSPVVFSDSVSDGGFWRCENSPSSVSNDYPMMMAEEPQFEDCLLARMPSFDAELIWDILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NAA1</accession>
    <name>A0A0D2NAA1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_001G162900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NAA1"/>
    <dbReference type="STRING" id="29730.A0A0D2NAA1"/>
    <dbReference type="Gramene" id="KJB09763">
        <property type="protein sequence ID" value="KJB09763"/>
        <property type="gene ID" value="B456_001G162900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002432">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="16">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="17">
        <location>
            <begin position="118"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00037296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="243" mass="26784" checksum="EF0BC6E859AF0610" modified="2015-04-29" version="1">MHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSLTALPVIETQAGDVSAYIPTNVIPITDGQICSETELFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSLKLELAQYREVAALAQFGSDLDAATQALLNRGARLTEVPKQPQYSPLPIEKQILVIYAAVNGFCDRMPLEKISQYERAIPKSIKPQLLQSLLEKGANERKIEPDTFLKESALPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NE05</accession>
    <name>A0A0D2NE05_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G251900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NE05"/>
    <dbReference type="STRING" id="29730.A0A0D2NE05"/>
    <dbReference type="Gramene" id="KJB11291">
        <property type="protein sequence ID" value="KJB11291"/>
        <property type="gene ID" value="B456_001G251900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB11293">
        <property type="protein sequence ID" value="KJB11293"/>
        <property type="gene ID" value="B456_001G251900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767621"/>
    <dbReference type="eggNOG" id="ENOG502QSH7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MPERRCE"/>
    <dbReference type="OrthoDB" id="778365at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18915">
        <property type="entry name" value="bHLH_AtLHW_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043561">
        <property type="entry name" value="LHW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH155-LIKE ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46196:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR EMB1444-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23176">
        <property type="entry name" value="bHLH_LHW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="536"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB11293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="716" mass="78852" checksum="30428DA6677928AA" modified="2015-04-29" version="1">MGSSTTSSGLYQILRSLCLNTEWKYAVFWKLKHRARMVLTLEDAYYDNHDQRGPSENNCFRDTLQNLHTGCYSHDPLGLAVANMSYHVYSLGEGIVGQMAVSGKHQWIFADEHVNSSCSSFEFRDGWQSQFEAGIRTIVVVAVVPQGVVQLGSLNKVVEDVKLVSHIRDVFFALQDSSVGHIANPIECSMKSSVFEPELHTKLLESEIISLDKAVDKEGPDFLLPEFSHHQKCSDSSFVFPLSSNPQKGLELSAAGRDESAKLLTPRSNVSNLEHLNQLGRNLINNVVCKGETSGWKSARMGPENVYASHPVVGSTTCGSNFLQPAVSDTVKLGGLNSYQNEVLDIPESSDVKFLKDLKFGNLNDLSDLDSINTSSKFSAGYELYEALGPAFLRKSIYTDWQVEKTEAGTEMLEGMSSSQLTFESGSENLLEAVVANVCHSGSDIKCERSFCRSAPSLVTTVNTPDLSSQTNFTISSAGYSINQSSLVENNTQQFLNSSKLCGAMSSNGFSSAGPSNCSEQLERSSEPAKNNKKRARPGENPRPRPRDRQLIQDRIKELRELVPNGAKCSIDSLLERTIKHMVFLQGITKHADKLSKCAESKMHHKGAGMLGSSNYEQGSSWAVEVGSHLKVCSIVVENINKNGQMLVELLCEECSHFLEIAEAIRSLGLTILKGVTEAHGEKTWICFVVEGQNRVMHRMDILWSLVQILQPKATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKI2</accession>
    <name>A0A0D2NKI2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_006G017100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKI2"/>
    <dbReference type="STRING" id="29730.A0A0D2NKI2"/>
    <dbReference type="Gramene" id="KJB33552">
        <property type="protein sequence ID" value="KJB33552"/>
        <property type="gene ID" value="B456_006G017100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RERPGHK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823:SF3">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB33552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11195" checksum="AF2A2BAA36C0CCD5" modified="2015-04-29" version="1">MVNLKVLLMQLRYFSKYIQPTPIILPINILEDFTNPLSVSFQLFGNVLVDELIVVFPVSLVPSVVPILIMFLGLFTSGIQALIFATLVAVYVGEFMEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKJ0</accession>
    <name>A0A0D2NKJ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc transporter 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_002G098900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKJ0"/>
    <dbReference type="STRING" id="29730.A0A0D2NKJ0"/>
    <dbReference type="Gramene" id="KJB13868">
        <property type="protein sequence ID" value="KJB13868"/>
        <property type="gene ID" value="B456_002G098900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781650"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEMSHTH"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF217">
        <property type="entry name" value="ZINC TRANSPORTER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248106" description="Zinc transporter 11" evidence="6">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB13868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="37680" checksum="3E16B8BB23AC460B" modified="2015-04-29" version="1">MKLSRFLFFFFLCLSLFISVTCHGGSHADGDDDDDDKAGERNEPHDLRSKSLILVKVWCLILVFVGTFVGGVSPYFLKWNQGFLVLGTQFAGGVFLGTAMMHFLSDANETFGDLTTKEYPFAFMLACAGYLLTMLADCVISYVYGKGKNSCNNGDLELQGAERSKTNPHGQGDPPVGNGTDTTCAQSLSLTSASSFGDSVLLIVALCFHSVFEGIAIGVAETEADAWKALWTISLHKIFAAIAMGIALLRMIPDRPLLSCIAYAFAFAISSPVGVAIGIIIDATTQGAVADWIFAISMGLACGVFIYVSINHLLAKGYAPQKTVSVDRPHHKFLSVLLGVGVIAVVMIWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NMQ0</accession>
    <name>A0A0D2NMQ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G135300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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                <person name="Gundlach H."/>
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                <person name="Duke M.V."/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="TRL33"/>
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    <dbReference type="PANTHER" id="PTHR47571">
        <property type="entry name" value="THIOREDOXIN-LIKE 3-3"/>
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        <property type="entry name" value="THIOREDOXIN-LIKE 3-3"/>
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    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
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        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="18"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB36502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="87" mass="10236" checksum="07A05DDEBE8AEC78" modified="2015-04-29" version="1">MVCTQSVWCKVSVTKESVCSQILPAFCKLSNQFPKLSFVYADIDECPETRKHIRYTSTFHFYRDGERVDEMFGAGEERLHDRLWLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NZ27</accession>
    <name>A0A0D2NZ27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G269400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2NZ27"/>
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        <property type="protein sequence ID" value="KJB38727"/>
        <property type="gene ID" value="B456_006G269400"/>
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    <dbReference type="KEGG" id="gra:105800810"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="601405at2759"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:protein heterodimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Histone, subunit A"/>
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        <property type="entry name" value="PROTEIN DR1 HOMOLOG"/>
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        <location>
            <begin position="14"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB38727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="156" mass="17443" checksum="838D54A62610AD2D" modified="2015-04-29" version="1">MEPMDIVGKSKEDASLPKATMTKIIKEMLPPDVRVARDTQDLLIECCVEFINLISSESNEVCNREEKRTIAPEHVLKALEVLGFGEYIEEVYAAYEQHKIETMHDSLKGGKWSNGAEMTEEEAAAEQQRMFAEARARMNGGAVVPKQPESDPSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NZP5</accession>
    <name>A0A0D2NZP5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G112000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_003G112000"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 3"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZnB-Zn_EMF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056068">
        <property type="entry name" value="EMF2-like_DUF7651"/>
    </dbReference>
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        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057540">
        <property type="entry name" value="Znf_SUZ12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF22">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN EMBRYONIC FLOWER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24663">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23320">
        <property type="entry name" value="Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUF7651" evidence="9">
        <location>
            <begin position="71"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein SUZ12-like zinc finger" evidence="8">
        <location>
            <begin position="285"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="7">
        <location>
            <begin position="489"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB19638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="629" mass="71440" checksum="643318DAC017E56B" modified="2015-04-29" version="1">MPGIPLVARETSSYSRSTDQMCREDSRLHLSAEEEIAAEESLSIYCKPVELYNILQRRAVRNPLFLQRCLRYKIQAKHKMRIQMSVSISRIVNEGVLTQSLFPLYILLARVVSDVAVAEYSAVYRFRRACILTSFTGIEGSDQAQANFVLPEINKLAMEAKSGSLAILLVSFANGGCCLWGRIPLESLYLSWEKAPNLSLGQRAEMIFPVDMHSCLLKLTSLNEDKCILIQNSSNSLLMNESLQLQVIISAEEVGAKENSPYNSYTCSGVSSSSSLSHIIRLRAGNVIFNYRYYNNKLQRTEVTEDFSCPFCLVKCASFKVGLRHHLPASHDLFNFEFWVTEEYQAVNVSVKTDSWRSEIVADGVDPKQQTFFFCSKQLRRRRPKNLDQNARRLHPVFMESKLPAGGCELLDKAHGGTILRNATIGALEYAQHVPSSFNVPGVSGAAGQLYSDSEHVQSVSGNNLAPPALLQFAKTRKISMERSDPRNRTLLQKRQFFHSHRAQPMAMDQVVSDRDSEDEVDDDVADFEDRRMLDDFVDVTKDEKQIMHLWNSFVRKQRVLADGHIPWACEAFSNLHGRNLVKAPALIWCWRLFMIKLWNHGILDARTMNNCNIILEQYEKQDLHPIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4X2</accession>
    <name>A0A0D2P4X2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G009900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4X2"/>
    <dbReference type="STRING" id="29730.A0A0D2P4X2"/>
    <dbReference type="Gramene" id="KJB21713">
        <property type="protein sequence ID" value="KJB21713"/>
        <property type="gene ID" value="B456_004G009900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790018"/>
    <dbReference type="eggNOG" id="KOG0037">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYNILMH"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16180">
        <property type="entry name" value="EFh_PEF_Group_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044590">
        <property type="entry name" value="CML48/49/50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46824:SF2">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN CML48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="67"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB21713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="235" mass="26520" checksum="19F277AFF7D3F7C4" modified="2015-04-29" version="1">MATSRPYSSHSTAPSAPELPPQSYDHHHQPPQQHQQHQSYYGQYPTPSPPPSSSSSYGPSGGGFPAGTSPDVIRAFQMVDRDRSGFIDEYELQQALSSGYQRFNLRTIRLLMFLFKNPYDSLRIGPMEFAALWSCLGHWRAVFERFDRDRSGKIDLMELRDALYSLGYAIPPSVLQLLISKYDNGLNFDSFVECGMIIKGLTEKFKEKDPGYTGSATLSYDSFMSLVIPFLVSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P560</accession>
    <name>A0A0D2P560_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G016700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P560"/>
    <dbReference type="STRING" id="29730.A0A0D2P560"/>
    <dbReference type="Gramene" id="KJB21833">
        <property type="protein sequence ID" value="KJB21833"/>
        <property type="gene ID" value="B456_004G016700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0331">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7650" checksum="638F5F8E384896B2" modified="2015-04-29" version="1">MLDMGFEEDVRFILGKTCSARQIVMFSATWPVAVHRLAQEYMDPNPVKVVIGSEDLAANHDVMQIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PI59</accession>
    <name>A0A0D2PI59_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G324800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PI59"/>
    <dbReference type="STRING" id="29730.A0A0D2PI59"/>
    <dbReference type="Gramene" id="KJB45742">
        <property type="protein sequence ID" value="KJB45742"/>
        <property type="gene ID" value="B456_007G324800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IRMGHEN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004:SF439">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB45742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42765" checksum="DAB5309562B2A87B" modified="2015-04-29" version="1" fragment="single">RLPTPPPSLLCYFVSRNKLVGDIPSSICNASSLEVLTLWNNSINGTIPECIGNLSSSLSHIDLGNNNFHGGSLPRSLGNCKDLNLLDVGNSNLNDTFPNWLGNLDHLQVLVLRSNKFFGQMDNSDVTVPFPRLRVIDLSHNNFSGYLPTNFFKNLQSIRMGHENKLEPEYMEDVSDYIAFNYAYGLSFTVKGSETEFQSVLTSWMVIDFSDNQFFGELPKTLGELHSLIVLNLSHNCLTGPIPSSLGDLSELESLDLSSNKFQGRIPTELTNLGFLEVLNLSQNNLKGPIPQGKQFDTFTNDSYKENLGLCGLPLSKRCDNDRGTLVKFDTDDELNWKFSILMGYGCGLVLGLNMGYIVFATGKPWWLIRIVERVQQRFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PKS9</accession>
    <name>A0A0D2PKS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein EARLY FLOWERING 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G024100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PKS9"/>
    <dbReference type="STRING" id="29730.A0A0D2PKS9"/>
    <dbReference type="Gramene" id="KJB07439">
        <property type="protein sequence ID" value="KJB07439"/>
        <property type="gene ID" value="B456_001G024100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804396"/>
    <dbReference type="eggNOG" id="ENOG502QSB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPWSFNQ"/>
    <dbReference type="OrthoDB" id="1939092at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039319">
        <property type="entry name" value="ELF3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34281">
        <property type="entry name" value="PROTEIN EARLY FLOWERING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34281:SF2">
        <property type="entry name" value="PROTEIN EARLY FLOWERING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="704" mass="76543" checksum="E9E45269549D3DD3" modified="2015-04-29" version="1">MKRGKDDEKNMEPMFPRLHVNDTEKGGPRAPPRNKMALYEQLSIPSQRFNPGLLPLNTSNSSSLVPPTSSSQGSCLQNRLFPSRVSNSASTNQAEKIHTRQHGGASVNAPMARLEPRKKVGDEDDFLVPVFVNSETGLQHCKNKEGFDGEKVCNVRDNDTNRCSSSGVGSRKEVRNQSEGSFQVCSSRERSIKPAANSSTRETIDGYAKEDNVSPDQYCEEIPASRLSGSREIDACLVEKLRADRQPVDNGCADDASLMKENGEGTLSRKRSLSYSEGNRSVPDETNNDSECHEDKTCGSLQWANGDKSDDVSETSAVDIVSGLDISADDVVGIIGQKRFWKARRAIVNQQRVFAVQVFELHRLIKVQRLIAGSPHILLEDAAYLSKPSFKDSPVKKLPQELIVKPVPQNNRKDDAEKISCKMECSAENAVGRTSLSSVKNGSQPSNNGPFLGNSPLSPANGDNKMNPWCFNQMLGHQWLVPVMSPSEGLIYKPYPGPGFMESACGGCGPFGQNPMTGNFMTSAYGVPTPHQGLGALPGTPLGGHSYFPPYGMPVMNPAFSGSAMEQMTQFAGVGSHAQSVQLSGSGANFNMQQQSSSNLPNEKNGAIPPVTKYQASKDAEQQRCNASSPSERTEKDGTRSTSEGKNTPSLLPTAPANLEGALKPRETDQRTRVIRVVPHNPRSATESAARIFQSIQKERKQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PU64</accession>
    <name>A0A0D2PU64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_001G198100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PU64"/>
    <dbReference type="Gramene" id="KJB10379">
        <property type="protein sequence ID" value="KJB10379"/>
        <property type="gene ID" value="B456_001G198100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800492"/>
    <dbReference type="eggNOG" id="ENOG502QSFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWETRCG"/>
    <dbReference type="OrthoDB" id="652551at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000307">
        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000585">
        <property type="entry name" value="Probable inactive receptor kinase At1g48480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000234">
        <property type="entry name" value="Probable inactive receptor kinase RLK902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050994">
        <property type="entry name" value="At_inactive_RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF32">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249218" description="Protein kinase domain-containing protein" evidence="15">
        <location>
            <begin position="27"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="236"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="338"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB10379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="630" mass="68785" checksum="F5FB01298D05F19B" modified="2015-04-29" version="1">MKLNSSIFCLCLFWTTLFVSMNSDLASDRAALVGLRAASGGRTLLWNLSRSPCNWTGVRCVQNRVVELRLPGVGLSGPLPIAIGNLAQLHTLSLRFNALSGSIPYDFAKLTSLRKLYLQGNRFSGEIPAFLFTLQKLIRLNLANNNFTGTIPESINNLTRLGTLYLENNHLSGSIPDIDLPALVQFNVSFNQLNGSIPKGLSGKPKTAFEGNSLCGKPLVSCNGTENSSSSSGDKWSSGVIAGIVVGCVTAVLLILIILVFLCKRKGSKKMETRDIAPPKQAEVEIPAADKAAGESDNTSNRLSGVVKKDAIAKSSGSKKLVFFGNRSRVFYLEDLLRASAEVLGKGTFGTAYKATLELGMVVAVKRLKDVTVSEKEFKEKMEVVGAMDHPNLVPVRAYYFSRNEKLLVYDYMPMGSLSALLHGNRGAGRIPLNWETRCGIALGAARGIAYLHSKGPEISHGNIKSSNILLTTSYEARISDFGLAQLAGPTSAPDRVNGYRAPEVTDVRRVSQKADVYSFGILLLELLTGKAPRHALLNEDGVDLSRWVQSVVPEEWTTEVFDHELLRHQNVEEDMVKLLQLAIDCTAQYPDKRPSLSEMTTRIEELHGPTTEKEIHQIHEAENGSSEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PX68</accession>
    <name>A0A0D2PX68_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribosomal protein L7/L12 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G263100</name>
        <name evidence="12" type="ORF">Gorai_021933</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PX68"/>
    <dbReference type="STRING" id="29730.A0A0D2PX68"/>
    <dbReference type="Gramene" id="KJB11499">
        <property type="protein sequence ID" value="KJB11499"/>
        <property type="gene ID" value="B456_001G263100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768770"/>
    <dbReference type="eggNOG" id="KOG1715">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHRATFV"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_bL12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF26">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12CX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="10">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Xu C."/>
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                <person name="Wang Z."/>
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                <person name="Reddy U.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
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    <feature type="DNA-binding region" description="Homeobox" evidence="2">
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
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            <position position="167"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="167" mass="19133" checksum="2822D2BB429B0F3C" modified="2015-04-29" version="1" fragment="single">MVALLSVSPKLRSYWNPGVFEISMETVLQEHHNQMPAREILESLAEKFSESTERKGRTIVQFKQVWNWFQNRRYAIRAKSSKVPGKLNVTSMPRDDSNPVRNVLQPVAAPMPPPMAAPMSTAMPATTGRMDFDSVFEVLKASFLFPKFGINNWMLHSPFSYLSEIWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
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                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q803"/>
    <dbReference type="STRING" id="29730.A0A0D2Q803"/>
    <dbReference type="Gramene" id="KJB15379">
        <property type="protein sequence ID" value="KJB15379"/>
        <property type="gene ID" value="B456_002G174200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785658"/>
    <dbReference type="eggNOG" id="ENOG502R97J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEECGGC"/>
    <dbReference type="OrthoDB" id="10044893at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF16">
        <property type="entry name" value="F-BOX PROTEIN SKIP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB15379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0580926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="316" mass="36147" checksum="7ECFC5D6DEBE72B5" modified="2015-04-29" version="1">MEIAKSMELATLSHKQSSFAGPPHEALFLVLAYLPLFELLSMSEVCRSLRDAVEKDVLPWLNVIVERPLSLRLSDEILMKIASKANGRLRTLVLMYCAKITDDGLQRVIDQNPLISKLHIPGCTGLTPDGVIRALQKLSDCQDGLKSLWINGIANMKKEHLERLQFYLQTNQKLPQIQQTRQPLLYHNYRRLRAYRWEELGRVIDVELCPKCNEVRVVFDCPREECKRKRENSMTGCRMCMFCIPRCEECGKCVENGDLEETVCADTLCLDCWIQLPKCNFCNKPCCTQHANMQIASTGSIGWICSVCHDKSDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QB00</accession>
    <name>A0A0D2QB00_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="7">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G108700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QB00"/>
    <dbReference type="STRING" id="29730.A0A0D2QB00"/>
    <dbReference type="Gramene" id="KJB14046">
        <property type="protein sequence ID" value="KJB14046"/>
        <property type="gene ID" value="B456_002G108700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCQMIRL"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000020">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="8">
        <location>
            <begin position="90"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="426" mass="45273" checksum="D4A951796DC3A7C1" modified="2015-04-29" version="1">MAFSSLIRSTAAVSPLLQASARSDLSPSPSYRLKVSSIGFGGNLNSFFGAAVSTKSSSLQKCNSRSIQPIKATATEIPPTIARSRSSGKTKVGINGFGRIGRLVLRVAIARDDFDVVAVNDPFIDANYMAYMFKYDSTHGGFKGTIRVVDDSTLEINGKQIQVVNKRDPAEIPWGDYGAEFVVESSGVFTTLAKASAHLKGGAKKVVISAPSADAPMFVVGVNEKTYKPSMDIVSNASCTTNCLAPLAKVVHEEFGIIEGLMTTVHATTATQKPVDGPSMKDWRGGRGAGQNIIPSSTGAAKAVGKVLPQLNGKLTGMAFRVPTPNVSVVDLTCRLQKSASYDDVKAVIKYAAAGPLNGILGYTEEDVVSNDFVGDSRSSIFDAKAGIGLSDSFMKLVSWYDNEWGYSNRVLDLIEHISLVLATHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QB51</accession>
    <name>A0A0D2QB51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G235500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QB51"/>
    <dbReference type="Gramene" id="KJB16559">
        <property type="protein sequence ID" value="KJB16559"/>
        <property type="gene ID" value="B456_002G235500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786295"/>
    <dbReference type="eggNOG" id="ENOG502SKZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034432">
        <property type="term" value="F:bis(5'-adenosyl)-pentaphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008893">
        <property type="term" value="F:guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="NUDIX_Ap4A_hydrolase_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000032">
        <property type="entry name" value="Nudix hydrolase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00298">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022927">
        <property type="entry name" value="RppH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001936">
        <property type="entry name" value="PRK00714.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001938">
        <property type="entry name" value="PRK00714.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF21">
        <property type="entry name" value="NUDIX HYDROLASE 27, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="219"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="265" mass="30112" checksum="1BCBA7D90930F758" modified="2015-04-29" version="1">MAGCQLVGNSVFYGTERRNCHCQLVKFSGVPLFYPLLNVPLTNISASLSNEGPPDGYRKNVGICLVNPSKKIFTASRIYIPNTWQMPQGGANKGEDLRKAAMRELREETGVTSAEFLAEAPYWLTYDFPIKVKDKLNRRWGTNYKGQAQKWFLFKFTGNEEEINLLGDGSEKPEFKEWSWRLPEQVVELAVDFKKPVYEQVLKVFSPYFSSDADKEQCLTKNERNGGKIHKQTTKRSSTKNKPNGGKKIHKQTKRCSTSLQGQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBY9</accession>
    <name>A0A0D2QBY9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_002G253900</name>
        <name evidence="16" type="ORF">Gorai_023663</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H2B family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB16909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QBY9"/>
    <dbReference type="Gramene" id="KJB16909">
        <property type="protein sequence ID" value="KJB16909"/>
        <property type="gene ID" value="B456_002G253900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHKIVKT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 12" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="117"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB16909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0581486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="217" mass="24202" checksum="358F167E32A5226D" modified="2015-04-29" version="1">MVNCPYLFPHGASNLTNSKDSTSSIRVKHNQPIRNHLSSICKQSHLPLNPQVTHSPIPRVLSFLIPFSKNPRFPHSLYPMAPKVGEKKPAEKKPAEKAPAEKRPKAEKKISKEGGADKKKKKVKKSVETYKIYIFKVLKQVHPDIGISSKAMGIMNSFINDIFEKLAQEASRLARYNKKPTITSREIQTAVRLVLPGELAKHAVSEGTKAVTKFTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCX9</accession>
    <name>A0A0D2QCX9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase ATM</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_006G189100</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QCX9"/>
    <dbReference type="Gramene" id="KJB37088">
        <property type="protein sequence ID" value="KJB37088"/>
        <property type="gene ID" value="B456_006G189100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0892">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000015">
        <property type="entry name" value="Serine/threonine-protein kinase ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000023">
        <property type="entry name" value="Serine/threonine-protein kinase ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057445">
        <property type="entry name" value="ATM_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25360">
        <property type="entry name" value="TPR_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="17">
        <location>
            <begin position="1957"/>
            <end position="2623"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="16">
        <location>
            <begin position="2729"/>
            <end position="3042"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="18">
        <location>
            <begin position="3054"/>
            <end position="3086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1908"/>
            <end position="1927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2063"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="2485"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1916"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2063"/>
            <end position="2081"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB37088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="3086" mass="351376" checksum="400878C35276A58C" modified="2015-04-29" version="1">MVTSSDVQEIVSKLSSDKAKAREDGIKLLSMWLEGERSIGFCKVIGQHTAKLKPNEIPQSETWPFLIKLLTQCVSLEISTSKRRPPKLIFAKTLRTAIQRAEDTKFPGNVYPLLSVVKTLFSHILDVINNVPSFQSEYGIILRHLLLVKEYRFHMRKNIYSGLMVFYLEKVATTLTEKNNTQYSQKEEIFRSILALHSLLENPAGDFPDHLREDIVKGFVKIFSYIRDEGKVSRKLIECINTYLLKDGPNLSCQSLEIHNAVQQFVFRCWLMTHDKGLKDALVLYARLQLNLVRGVTEGSLLVEQLLDVISKELDQSNSSIPGTSWRDGTKDDKFGTLSSSQQHLVELAALVLYRACATTSRATSNEKRAKRESTAARLKEELVKGKWLWNVTFCYLIRNYYTRISKDLFIYWFEGICASFERILNDANVEHAYDGLLWTLRSLQELSLMELPSNAQVEISLRSSLISKEFDCGWQLIWSHLMHGLPTFSNVTPVVDAALALLGSIISNDLSNTCVVPHDAWDLRLFKGMPSLCTLYFIACYFSRKGSQGDLRDILHLRKYLLRATLGSLSWNEPSLLNERLVLLLPAAVYALCAGCEPFTQCYKEIHLLQSFVDVIEVADDWIKADEYDHEKQLENFECSIEVLANIDLDSIIQVSSSHFHQSLRLPRQLRESLMQEMESCILGLLADLKFEKKPLSDIFFICALLCNFIYGLYFTRNREEVSSFLSKLGQILLELLNYAVNVIQENKNDSRSLGFLGFTSSFNQKSAIVVSFKTFVLGPLFTQRRDDDALDVVLYDAVKQSLQKLLKAFTELYDEYTESITNLRSELLASDSSGSDSSIRISNHADSNKSRIMDMELDVDEDGKDMTIQTSSGKTPSGGSFSAVKWKLGMVSLISSFFLVLHDKTWDVLSNLLGKELDFKVYEVILCNLCRRLPSLYSSKLTDLVNLIDNRIGVQVSQKLDCFNILAAIGYLLDTLLSLDVEKDKHGVVALEEREAKQSLVCLGELVGKVAEFDLLNWFGRVKLIDCICNFVLLSPEVGQTMIGKLLSMLHDPDYRVRFILSRRIGVLFQTWDGHGELFHDICSNFGIELIFYSKEKLVTAREVLAAGPQPRQKVETVIITLMQLALHSENIELEAVFMMCAVSSIDPCQRELVNAALDNLARKLKYMSRMKYLEELIGSILFCWVACGVSIAALVEIRQLFVLDAEPSYFLQYCFHWLLPALFIHEDNSNLNWISKIAGQPLTVVVKDHFVPIFSVCMTLHCSKSSGFEKGAMVLQNSILHFAEISESERDKLIKKNMVSIVSHILSLASCASDPIIPFFSRDTIARAIQTVVDGFLEMDDHCASISVVDKINIFRPDRVFMFIVEMHYKIAAAIHHRHRCHRLASIEVLITVLGHRAALSSTSNYLFNLIGQYIGCHALQDQCCCIISSLLKTFKSNPSKEIVGVLGEQLQFLVSKLVACCIPLEAEGQRSATVSSLFLSLLLELTVESDPSLYDYIRELEPFPEVDIFERIRNFHHDLCRAYSPRDHLLKVLQPSTKITFMEKPINTKSLPVHYEVIFYKVIVFKMLKVLHSIFRLGSAEISDMLLLLRCFMFLGPCSLQALHKKLLAGETFQGGKTTKEFVDDTYWHGDGEIVHAVWTLVRMCASDDSSRIRGLVSDLISRVGIGDPYSVVFHLPGDSNHMHVHGPISHNGASEIMGSSVSEELLIALLKVLKKYLMDDSVKIVDITSQTLRGILSTERGQKAILSFDSYERSLIEVHSKGINSELVEKLLMDLEKKFKAEDIFLEKSTTWVTHGKTFEMWICPVVYSLVGCCSDVILRLCQDVVLLKPEVAELLLPSVVVNLAGRKDIGVNIQSLISDQVQEHIFVKSNKLIKSIQVWLNALNELRICYVLERSSGPLRKENSKHCRPSNFSSRSHSSMKPRDSVATLSAVTMSTSSWAKVYWLSIDYLIVARSAITCGSYFTSMMYVEYWCEEHFHGLTLGNPDFSNLEMLPQHIEILISAITQINEPDSLYGIIQSHTLTSQIITFEHEGNWNKALEYYDLQVRSEATAHMDGSSRTLSLTETQSLSQPHLSTSDDEAKWKPYKGLIRSLQQIGCRHMLDLYCQGLTSGKGQFQQDLEFTELQYEAAWRAGNWDFSLLSAGPIPQSSEQHTKTHHFNENLHCCLRALQEGDSDEFQRKLKHSKEELVWSVSCASEESTEFIYSTIIKFQILYHLGIAWEMRWPTSSFDRIELQKHKQKMFSDPVIPTMDQLLWLNKDWSSMLTKSQLHMSLLEPFIAFRRVLLQILNCHDCTMQHLLQSASTLRKGSRFSQAAAALHEFKFLCVRTGEQGSSAYWLGRLEEAKLLRAQGQREMAIGLGKYILQTNRLDEEASDVYRLVGKWLAETRSSNSRTIFEKYLKPAVSLAEGDKTADKKSAERKSQTHFRLAHYADALFRSYEERLNSNEWQAAMRLRKHKVTLELEALMRRLKGSTKGDKIDYSMKIQELQKQLAMDKEEAQKLQDDRDNFLNLALEGYKRCLVIGDKYDVRVVFRLVSLWFSLSYRQDVVNNLLKTIDEVQTYKFVPLVYQIASRMGNIRDGIVPNNFQFALVSLLKKMAIDHPYHTIFQLLGLANGDRIKDKQRSRNSFVVDLDKKLAAENLLEELSAYHGPVIRQMKQMVEIYIKLAELETKIEDTSRKVPLPREIRSVRQLELVPVVTASFPVDRSCRYCEGSFPYFRGLADSVMVMNGVNAPKVVECLGSDGHKYKQLAKSGNDDLRQDAVMEQFFGLVNTFLQNHRDTWKRRLVIRTYKVVPFTPSAGVIEWVDGTLPLGEYLIGSNRNGGAHGRYGIGDWSFLKCRVHMSNEKDKRKAFQEVCENFRPVMHYFFLERFLQPADWFEKRLAYTRSVAATSMVGYIVGLGDRHTMNLLIDQATAEVVHIDLGVAFEQGLMLKTPERVPFRLTRDIIDGMGVAGVEGVFRKCCEETLSVMRTNKEALMTIIEVFIHDPLYKWALSPLKALQRQKETDYDLDTSIEGSQDDYEGNKDAARALLRVKQKLDGYEEGEMRSVHGQVQQLIQDAIDPERLCQMFPGWGAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QD27</accession>
    <name>A0A0D2QD27_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G032200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QD27"/>
    <dbReference type="Gramene" id="KJB17314">
        <property type="protein sequence ID" value="KJB17314"/>
        <property type="gene ID" value="B456_003G032200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S5G0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSKVTHY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33696:SF20">
        <property type="entry name" value="DUF688 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33696">
        <property type="entry name" value="T22J18.15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="153" mass="17127" checksum="3109EAA4BFDE0EDA" modified="2015-04-29" version="1">MNHRKVHSQGNIPFSWEDKPGVSKPSKVTHYGCPIDGGLYGDGGLLTDIAVRNNNEVPPPPPCSIRLPPPRRSTSLKGLRWWLDDPFLAAYKECTKSGEIKTGGSILPVRKKKIGFSCKNACDVRDDNLARLSNLPTLPKRKELVLERNWFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEL6</accession>
    <name>A0A0D2QEL6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G218300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEL6"/>
    <dbReference type="STRING" id="29730.A0A0D2QEL6"/>
    <dbReference type="Gramene" id="KJB37731">
        <property type="protein sequence ID" value="KJB37731"/>
        <property type="gene ID" value="B456_006G218300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37733">
        <property type="protein sequence ID" value="KJB37733"/>
        <property type="gene ID" value="B456_006G218300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800329"/>
    <dbReference type="eggNOG" id="ENOG502QTQ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTRAINW"/>
    <dbReference type="OrthoDB" id="2019294at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16914">
        <property type="entry name" value="EcfT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33514">
        <property type="entry name" value="PROTEIN ABCI12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33514:SF13">
        <property type="entry name" value="PROTEIN ABCI12, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB37733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="398" mass="44104" checksum="C06E4EB0611974E0" modified="2015-04-29" version="1">MNRTHSPIPTVKSPFHFVLSPNFKSLIHPTATRILNFPPKHPNRLPLLSYCSKSPNFRFISKKRNFEVKASTGSNNGEAGNWVRWLPTGGLAADKVLRLISTATSSPICQFISSPTTFLHSVDPRIKLVWLLALVVLPARAQIAVRFGLVAYIALLSMLFLPKNVWMDQLGRVSLLCGILFVLSGLGTDGVPQLLQSRTPPSSLTGLPDLPKSLSGYSYLIMKLGPLQFTRKGLSVASTASCLTFIIFQSASLCLATTTPEQLAFALRWFMLPLRYIGVPVAEIVLTLMLSLRFINLVFDEVRNVALGIVSRRINWQHLTMKETIDIFASYIQRIFKNIFKHAEQISQAMIVRGFRGDSNAHKLYFLSDSSIGMADLIAVVCLIGVTSVALLSEYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QH73</accession>
    <name>A0A0D2QH73_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G161700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
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    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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            <end position="81"/>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="compositionally biased region" description="Basic residues" evidence="9">
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            <end position="230"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB19979.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0582552.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
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    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45399" checksum="921864B5EB0C1102" modified="2015-04-29" version="1">MDHERAPILRSKDQKKIEMPLALVSEESNIILIPAELKCFSVSTSRQENITLESKERQKSASQLSGLIIFYLVVMLVEIVGGMKANSLAVLTDAAHLLTDVAGFSISLFTVWASAWKATSNHSFGFSRLEVLGALISVQLIWLVSALLIYEALNRLLHDKQKVDGALMFAIAAFGFFINLIIVLWLGHDHSHHVFGNNHHHHHHHHHHVHLHDHHHHHEHLHDHHHHHEHHDHEGGKPCDLTEEDETSLVTSTPKTKILNINLQGAYLHVMADLIQSVGVMIAGAVIWLKPNWLIVDLLCTLIFSTFALSTTLPMLRDVFDILMGRTPRDINIDMVEDGIKGINGVESVHDLHVWAITVGKLVLSCHVVAKPGVESKEMISKIRDYCESTYKIHHITVQIEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKM2</accession>
    <name>A0A0D2QKM2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G045600</name>
        <name evidence="10" type="ORF">Gorai_020535</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QKM2"/>
    <dbReference type="Gramene" id="KJB07810">
        <property type="protein sequence ID" value="KJB07810"/>
        <property type="gene ID" value="B456_001G045600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782472"/>
    <dbReference type="eggNOG" id="ENOG502QQH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWILTIQ"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20404">
        <property type="entry name" value="Tudor_Agenet_AtEML-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Tudor" evidence="8">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="442"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="916"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1073"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1144"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0578239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1686" mass="190403" checksum="363815761CABEB99" modified="2015-04-29" version="1">MRKVGDFVFPVWIEGLLMENRIGNSHGAEIPKKSRSLDLKSLYKSGDSKESSENRSLKRKESSQEGDGEKRSNNNNKRKKSRKSLPLSSFRTVHDSDSSKSLTEVYNGGFSSKLHDPKSLKKLGLSQKSNNGCTADGISVSLGNNGTKIPRRKRRFVGRKKFEDGQALKLAGRSNCKEVVNEEVKLVSEDSGIQNESLKVKQDKIDDFKENRNSESISIQHLKEEDGVAGYSAVNDGDSLLRKPQRKPRKRKDSVKSDKSVANMAESLVETCDAFQEDDEENLEENAARMLSSRFDPCCTGFSSNSKVSVAPSDNGLSFLLSSGQNASSGSKNLSGSESASVDASGRILRPRKSHKEKVNSRKRRHFYEIFSGDLDADWVLNRRIKVFWPLDKNWYYGLVYDYDKERKLHHVKYDDRDEEWIDLRNERFKLLLFPSELPCKSQRKRTRRDRGSDDRIRNVKLNKENGKKNFMTEDDSSNGSYMDSEPIISWLARSTHRVKSCPLRSMKRQKTSASSLSSPGQPLSCDEAVDENGCLYEGSLKGSKVKLFNSTALPGKTVGSRRVQDSSLGSTSYPNRKHPIVYFRRRFRRTDNVLCQASKGNFIASSASESISSFVCVDEFQDLGVVDACLGRLDPERDLLFSDNAGQLQLNISLIHSKQFRLGLSFPVPSVSNNLFGTKCLWLVRTFLLLQCGTVMTVWPMVHMEILFVDNEVGVRFFLFEGSLKQAIAFVFQVLMVFYRPTEQGKYTDMQLPVTSIRFKFSCSQDFRRQIVFAFYNFHDVKHSKWMSLDSKLKKHSLLNRQLPLSDCTYDNLKALQNGTNQLLGSPACKVSSSVEGLSRRKYRQGISLMGVSRESSFLKLGQFSCNSEKLRNLPRFALSFGAAPTFFLSLHLKLLMERSLARISFGDHDSIEQPGSSGNLLLDDSSSREDSMNNNSESSVEKNLKASSKEVASDAELTSDLSVCGNGCLKKSSREYKNNDQIVDGTFAGSHESEVGAIAFVPLQKQQCDNSETQQFVLSSKSPFDADKETASSGSILSGIRVEIPPFDQYGKHVDSELPSTRQSTDLTLNMNGGIIPSPNPTAPRSTWHRNRSSSSIGFHARGWSDGKADFFHSNFGNGPKKPRTQVSYSMPLGSLDYSSKSKGLQQRVLPHKRIRRANEKRSSDVSRGSQRNLDLLSCDANVLITIGDRGWRECGVQAVLELFDHNEWKLAVKVSGSTRYSYKAHQFLQPGSTNRFTHAMMWKGGKDWILEFTDRSQWALFKEMHEECYNRNVRAASVKNIPIPGVSLIEEYDENAVEVAFVRSSSKYLRQVETDVEMALDPSRVLYDMDSDDEQWISIIQKSSGSDIGNSLELSDEMFEKIMDMFEKAAYTQQCNEFTSEEIQEVTAGVGSMKVITAIYGHWKQKRQRVGMPLIRHLQPPLWERYQQQVREWELAMSKANSKSIEKPPMFAFCMKPRGLELPNKGSKHRSQRKISVSGQSQHALGDHEGCHSFGRRSNGFLFGDEKVLYPAHNYESLEDSPLSQASPRSRDAGNMAYFPMGSDRFDKNHIKKLQRSKSKKYGSFLPSNGPQMMDSYNHRLIGKRNGIHQWNRGICEWSSQRHYFPDSLQRHGPEQWDNSDIDEFTLRDASSAAQHALKMAKFKRERAQRLLFRADLAIHKAMVALATAEAMKESSEDLNGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLI7</accession>
    <name>A0A0D2QLI7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G046800</name>
        <name evidence="4" type="ORF">Gorai_017961</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">8</strain>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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    <accession>A0A0D2QMS1</accession>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
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    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
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    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the thioredoxin family. Plant M-type subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB59367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QMS1"/>
    <dbReference type="Gramene" id="KJB59367">
        <property type="protein sequence ID" value="KJB59367"/>
        <property type="gene ID" value="B456_009G251900"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Thioredoxin"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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        <property type="entry name" value="Thioredoxin_CS"/>
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        <property type="entry name" value="Thioredoxin_domain"/>
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        <property type="entry name" value="GEO12009P1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN M5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="THIOREDOXIN"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="67"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023284"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
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    </gene>
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB21099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QMV8"/>
    <dbReference type="STRING" id="29730.A0A0D2QMV8"/>
    <dbReference type="Gramene" id="KJB21099">
        <property type="protein sequence ID" value="KJB21099"/>
        <property type="gene ID" value="B456_003G183100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789364"/>
    <dbReference type="eggNOG" id="ENOG502QQRT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYMVTIR"/>
    <dbReference type="OrthoDB" id="664300at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB21099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30479" checksum="47E488F6E2090A82" modified="2015-04-29" version="1">MALSNNVIGAINFVAMLLSIPILGAGIWLSNQPADSCLKILLWPIITLGVLILVMALAGFVGAFWRIPWLLMAYLVGMLVLIILLACLVIFMYMVTIRGSGHIVPNRAYLEYHLEDFSIWLQRRVRGSYKWERIETCLSTTQICPDLNQTYTMAMDFFRAYLTLIESGCCKPPTECGYTFVNPTNWISPINNIADPDCIQWNNDQTKLCYSCNSCKAGLLASLKQEWRRADIILLVTLIALICVYLVGCCAFRNAQTEDIFRKYRQGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNB6</accession>
    <name>A0A0D2QNB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="7">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G075600</name>
        <name evidence="15" type="ORF">Gorai_018181</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="7"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0589434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNB6"/>
    <dbReference type="STRING" id="29730.A0A0D2QNB6"/>
    <dbReference type="Gramene" id="KJB40737">
        <property type="protein sequence ID" value="KJB40737"/>
        <property type="gene ID" value="B456_007G075600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40738">
        <property type="protein sequence ID" value="KJB40738"/>
        <property type="gene ID" value="B456_007G075600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40741">
        <property type="protein sequence ID" value="KJB40741"/>
        <property type="gene ID" value="B456_007G075600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40742">
        <property type="protein sequence ID" value="KJB40742"/>
        <property type="gene ID" value="B456_007G075600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802433"/>
    <dbReference type="eggNOG" id="KOG0581">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06623">
        <property type="entry name" value="PKc_MAPKK_plant_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000432">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000012">
        <property type="entry name" value="Mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000527">
        <property type="entry name" value="mitogen-activated protein kinase kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="83"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="NTF2" evidence="13">
        <location>
            <begin position="366"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB40738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0589434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="518" mass="57653" checksum="E27FE750E530A90C" modified="2015-04-29" version="1">MSGLEELRKKLAPLFDAEKGFSAGSTLDPYDSYMLSDSGTVNLLSRSYGVYNINELGLQKCTSSPVDETDQGEKTYRCASHEMRIFGAIGSGASSVVQRAMHIPSHRILALKKINIFEKEKRQQLLTEIRTLCEAPCSEGLVEFHGAFYSPDSGQISIALEYMDGGSLADILRLKKSIPEPVLSSMFQKLLQGLSYLHGVRHLVHRDIKPANLLVNLKGEPKITDFGISAGLDNSMAMCATFVGTVTYMSPERIRNESYSYPADIWSLGLALFECGTGEFPYMANEGPVNLMLQILDDPSPSPPKHKFSPEFCSFIDACLQKDADARPTAEQLLSHPFIKKHEHDTVDLAAFVRSVFDPTQRLKDLADMLTLHYYLLFDGPDENWQHARTLYNEDSTFSFSGKQFVGPNDIHAKLSSIRGTLAGDWPPEKLVHVVEKLQCRAHGQDGVAIRVSGSFIIGNQFLICGDGLQVEGMPNFKDLSIDIPSKRMGTFQEQFIMEPGNVIGRYFIAKQELYIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNQ1</accession>
    <name>A0A0D2QNQ1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G057200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2QNQ1"/>
    <dbReference type="Gramene" id="KJB18481">
        <property type="protein sequence ID" value="KJB18481"/>
        <property type="gene ID" value="B456_003G057200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXIP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SVCAEYC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040377">
        <property type="entry name" value="Ssl2009-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34048">
        <property type="entry name" value="LOW-DENSITY RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34048:SF3">
        <property type="entry name" value="LOW-DENSITY RECEPTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="154" mass="17093" checksum="810B5C62408F30A2" modified="2015-04-29" version="1">MTSSFTPGSIDCSHLKAHDVWFTKSNNFRKTPSLAVRRKVIPSNCQFSVCAEYCRGGASDFAAGFLLGGAIFATIAYVFAPQIRRSLLNEDEYGFRKAKRLIYYDEGLEQTRQTLNKKISQLNSAIDNVSSRVRGGNNSPTVLVETEPEVEATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSE7</accession>
    <name>A0A0D2QSE7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G055000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSE7"/>
    <dbReference type="STRING" id="29730.A0A0D2QSE7"/>
    <dbReference type="Gramene" id="KJB22574">
        <property type="protein sequence ID" value="KJB22574"/>
        <property type="gene ID" value="B456_004G055000"/>
    </dbReference>
    <dbReference type="OMA" id="CNKFAIL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06222">
        <property type="entry name" value="RNase_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044730">
        <property type="entry name" value="RNase_H-like_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052929">
        <property type="entry name" value="RNase_H-like_EbsB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074">
        <property type="entry name" value="BNAC02G40300D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074:SF48">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="120" mass="13204" checksum="EA05FC2F196F888C" modified="2015-04-29" version="1" fragment="single">VKINVDATVSNGRMGFGVIARDDEGFVVGGCGGSKESTLNSEWAELLALEEGVQLARKLKLQRVVFESDNASIVNKIRRNGQDFTILGQRAYDTCMQLKTFEAADVTWAPRSCNKFAILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QX29</accession>
    <name>A0A0D2QX29_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Vacuolar protein sorting-associated protein 41 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_004G007900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QX29"/>
    <dbReference type="STRING" id="29730.A0A0D2QX29"/>
    <dbReference type="Gramene" id="KJB21666">
        <property type="protein sequence ID" value="KJB21666"/>
        <property type="gene ID" value="B456_004G007900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LSLCNCY"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16687">
        <property type="entry name" value="RING-H2_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000545">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000554">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057779">
        <property type="entry name" value="Znf_RING_Vps41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23555">
        <property type="entry name" value="zf-RING_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="12">
        <location>
            <begin position="41"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="10">
        <location>
            <begin position="610"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 C-terminal RING finger" evidence="13">
        <location>
            <begin position="870"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="904"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB21666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="950" mass="106653" checksum="FAAC603740F118E4" modified="2015-04-29" version="1">MSPFPSENGAEGEDERDEEEEDDVEDEEEEEEEEEEEEPRLKYQRMGGSVPSFLSNEAASCIAVAERMIALGTYDGTIHILDFLGNQVKAFAAHSAAVNELSFDKEGEYLGSCSDDGSVVINSLFIDEKLKFEYHRPMKAIALDPDYARKSSRRFVAGGLAGHLYFNTKKWLGYKDQVLHSGEGPIHAVKWRTSLVAWANNVGVKVYDAANDQRITFIERPRCSPHPEVLLPHLVWQDDTLLVIGWGTSVKIAAIRTNLNNGANGTYRHVSMSNMNQVDIVASFQTSYFISGIAPFGDALVLLAYIPSEEDGENGFSSTIPSRQGSAQRPEVRVVTWNNDELATDALPVHGFEHYKAKDYSLAHSPFSGSSYAGGQWAAGDEPIYYIVSPKDVVIAKPRDAEDHIAWLLQHGRHEKALAAAEAGQGRSELLDEVGSKYLDHLIVERKYTEAASLCPKLLRGSATAWERWVFHFAHLRQLPALVPYIPTENPRLRDTAYEVALVALATNPAFHTDLLSTVKSWPPVIYSALPVISAIEPQLNTSSMTDALKEALAELYIINGQYEKAFSLYADLMKPDIFDFIERHNLHDSIREKVVQLMMLDCKHAVSLLIQNRDLITPSEVVSQLLSSGNKCDSRYFLHLYLHSLFEVNPHARKDYHDMQVELYAEYDPKVLLPFLRSSQHYTLEKAYEICVRRDLLKEQVFILGRMGNSKQALAVIINELGDIEEAVEFVSMQHDDDLWEELIQQCLHKPEMVGVLLEHTVGNLDPLYIVNIVPNGLEIPRLRDRLVKIITDYRTETSLRHGCNDILKADCVDLLVKYYKEARRAVYLSNEEDDTRSKRDASGASLPIEKTSSVRNTVVKSKTRGGGRCCLCFDPLSIQNVLVTVFFCCHAYHTTCLTDSTYSNSNKKGTGPTSQEPYGYDNDDDEDEEDDQAGDARMRCILCTTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R063</accession>
    <name>A0A0D2R063_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe-S cluster assembly protein SufD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G186900</name>
        <name evidence="4" type="ORF">Gorai_015091</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R063"/>
    <dbReference type="STRING" id="29730.A0A0D2R063"/>
    <dbReference type="Gramene" id="KJB25344">
        <property type="protein sequence ID" value="KJB25344"/>
        <property type="gene ID" value="B456_004G186900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791947"/>
    <dbReference type="eggNOG" id="ENOG502QSI1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEMDNKP"/>
    <dbReference type="OrthoDB" id="2510at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055346">
        <property type="entry name" value="Fe-S_cluster_assembly_SufBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000825">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037284">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011542">
        <property type="entry name" value="SUF_FeS_clus_asmbl_SufD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045595">
        <property type="entry name" value="SufBD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01981">
        <property type="entry name" value="sufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575">
        <property type="entry name" value="PROTEIN ABCI7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43575:SF1">
        <property type="entry name" value="PROTEIN ABCI7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19295">
        <property type="entry name" value="SufBD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="Stabilizer of iron transporter SufD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD N-terminal" evidence="2">
        <location>
            <begin position="67"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SUF system FeS cluster assembly SufBD core" evidence="1">
        <location>
            <begin position="229"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB25344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0584269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="54209" checksum="D87CAD22BD1DC367" modified="2015-04-29" version="1">MAALTFIHQNLLHSTPKLTTSKPNLKPKRTKTKLSIQTIRESPQASFTDQFVLQLADSLEDSLPSSSSSSLPLQKLRDNSSETLLSTQWPSRKDESFRFTDTSFIKNSDINPISHPPNSLDLLEVSRDTQFEIFNFVDGFLVDSSFSSSNLPDGVYVGSLSKLSSEGILKRVCELLGDFEWGDLFWSVNGLGAPDLMVVYVPEGCRVENPIYLKYIAVEGADKGSKKMPLSNPRVFVLVEKGGEVGIVEEFVGKVGSECYWTNSVLEVVVGEGGKVSHSYLQKQSLSAAHIKWTSVRQEKTSTYELVEVSTGGKLSRHNVHVQQLGSDTVTELTTFHLSVGDQTQDLHSRIVLDHPRGYSQQVHKCIVAHSSGQAVFDGNVKVNRYAQQTDAGQLTRSLLLEPRATVNVKPNLQIIADDVKCSHGAAISDLEDSQLFYFQARGIDLEIAREALVFSFGAEVIDKLPYSFVQKQVKDHVKALLKSRRKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3P4</accession>
    <name>A0A0D2R3P4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G126900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family. NIP (TC 1.A.8.12) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R3P4"/>
    <dbReference type="SMR" id="A0A0D2R3P4"/>
    <dbReference type="STRING" id="29730.A0A0D2R3P4"/>
    <dbReference type="Gramene" id="KJB24068">
        <property type="protein sequence ID" value="KJB24068"/>
        <property type="gene ID" value="B456_004G126900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB24069">
        <property type="protein sequence ID" value="KJB24069"/>
        <property type="gene ID" value="B456_004G126900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB24070">
        <property type="protein sequence ID" value="KJB24070"/>
        <property type="gene ID" value="B456_004G126900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB24071">
        <property type="protein sequence ID" value="KJB24071"/>
        <property type="gene ID" value="B456_004G126900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791267"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSCFTDF"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046715">
        <property type="term" value="F:active borate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000013">
        <property type="entry name" value="Aquaporin NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724">
        <property type="entry name" value="AQUAPORIN NIP2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45724:SF11">
        <property type="entry name" value="AQUAPORIN NIP5-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="31130" checksum="9E8B3A23CB181209" modified="2015-04-29" version="1">MPDEETATPTASAPATPGTPGGPLFNSMRVDSLSYDRKSMPRCKCFPVTAPTWGQPHTCFTDFPAPDVSLTRKLGAEFVGTFILIFAATAGPIVNQKYSGAETLLGNAACAGLAVMIIILSTGHISGAHLNPSLTIAFAACRHFPWTQVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSVSHGQAFALEFLITFNLLFVVTAVATDTRAVGELAGIAVGATVMLNILVAGPSSGGSMNPVRTLGPAVAAGNYRALWIYLIAPTLGAVIGSATYTLVKLREDEVDAPRQVRSFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5M1</accession>
    <name>A0A0D2R5M1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 14 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G375700</name>
        <name evidence="8" type="ORF">Gorai_020173</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Gong L."/>
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                <person name="Grover C."/>
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                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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                <person name="Scheffler B.E."/>
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                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
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                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB46583.1"/>
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        <source>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
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                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
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        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
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        <location>
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        <location>
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            <end position="73"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB25276.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0584239.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="80" mass="9109" checksum="3E8E6B3412B12426" modified="2015-04-29" version="1">MELADRAVGFLLSITSLSIFTYYTFWVIILPFVDSDNFIHNYFLPQEYAILIPVCAGVVLLCLLCIFIGFVLLKSKKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R763</accession>
    <name>A0A0D2R763_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G017100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R763"/>
    <dbReference type="STRING" id="29730.A0A0D2R763"/>
    <dbReference type="Gramene" id="KJB47233">
        <property type="protein sequence ID" value="KJB47233"/>
        <property type="gene ID" value="B456_008G017100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053052">
        <property type="entry name" value="Imprinting_Balance_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45496">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45496:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB47233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="410" mass="45019" checksum="42E88215D0E39930" modified="2015-04-29" version="1">MLPTCQAAPAATFLSFFVDWFGSFNSIVLLIGSVPLTQSMEVVTTQYRKLAPPLNPAALFPFRSLESLQTQMLPPLPKGTQPQVAQPLSVVRSSSGDGYATLQGGQFSLNTNLPESTRPTLCVALDQLVSNTLILPWINRLGPIPMSQMDQSGNATSSQFDQTESTRMGQINQATPPSTEHSETDTTDVTWKTDSTRPSKPPDSESLTFWTACPYCYVLYEYPKVYEDCTLRCQAENCRRAFHAVVIPSPPPVDGKETYLCTMGFFPLGFSGNGENMGGNFPRWSPVSTMFACPNNKNAGKQTSAQKSAPRVFYDEDDIYIEISSAEDTNNDDDDDKWQKERRKKKAKGEGSVVRNAKTQRSERVNGNGRGVSMVPEAEPSKRGVTNSGYVEGLEEFLSSLHMLAVGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RM51</accession>
    <name>A0A0D2RM51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOX high mobility group box family member 4-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G136700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RM51"/>
    <dbReference type="STRING" id="29730.A0A0D2RM51"/>
    <dbReference type="Gramene" id="KJB20155">
        <property type="protein sequence ID" value="KJB20155"/>
        <property type="gene ID" value="B456_003G136700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788888"/>
    <dbReference type="eggNOG" id="ENOG502R3H5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CESGMIT"/>
    <dbReference type="OrthoDB" id="778241at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012862">
        <property type="entry name" value="DUF1635"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431">
        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431:SF12">
        <property type="entry name" value="HIGH MOBILITY GROUP BOX PROTEIN, PUTATIVE (DUF1635)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07795">
        <property type="entry name" value="DUF1635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB20155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="30686" checksum="B320BEEE8107CA9F" modified="2015-04-29" version="1">MEELGYLWNYQENLDELKLKLQYSSIQLESVKMEANEQIRKYKEEQKLMVNLLNLAYQERDEARDQLQKLLNKFMPCPPPQPETPLMVAAKTNSSITESNSLSHGSPPVDSFFDAVTSPDFPTIKMPADSTGMGLLNNQPFVQNGCGFVPSMVSPKPDGETAVIDKLAKGKTLPEKGKLLQAVMEARPLLQTLLLAGPLPQWRNPPPSNTFKIPPVSLNVCDSKPVVAPKRVNSSQYLEMSRGTRQMCSTAMLSFASSGAGAGVNNQITVTKRQRFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RN57</accession>
    <name>A0A0D2RN57_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G152800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RN57"/>
    <dbReference type="STRING" id="29730.A0A0D2RN57"/>
    <dbReference type="Gramene" id="KJB20515">
        <property type="protein sequence ID" value="KJB20515"/>
        <property type="gene ID" value="B456_003G152800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789719"/>
    <dbReference type="OMA" id="VFGHGAW"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080030">
        <property type="term" value="F:methyl indole-3-acetate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080032">
        <property type="term" value="F:methyl jasmonate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080031">
        <property type="term" value="F:methyl salicylate esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009696">
        <property type="term" value="P:salicylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045889">
        <property type="entry name" value="MES/HNL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992:SF1010">
        <property type="entry name" value="METHYLESTERASE 17-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10992">
        <property type="entry name" value="METHYLESTERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB20515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="126" mass="14224" checksum="C0682FFA45D892C0" modified="2015-04-29" version="1">MSETTEKLHFVVVHVFGHGAWCWYKIRSLLEASGYKVSCIDLKGSGMDPSDPNTIFSFQDYNKPLIDLLSNLPHNEKVILVGHSAGGMSLTYAIHRFSKKIRMAIYVAATMLKHGCQNHLLKNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RPQ9</accession>
    <name>A0A0D2RPQ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G189900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RPQ9"/>
    <dbReference type="STRING" id="29730.A0A0D2RPQ9"/>
    <dbReference type="Gramene" id="KJB72677">
        <property type="protein sequence ID" value="KJB72677"/>
        <property type="gene ID" value="B456_011G189900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTNYFEM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB72677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="269" mass="31498" checksum="C1B5D1BD34CADA92" modified="2015-04-29" version="1">MVDQSPADQTPPSSGMQMSLEEKFKIIRSVGEECIQEDELLNLLNHKPEPICYDGFEPSGRMHIAQLLRNLLCFFLNVEFLWSSDEINSRASEYWPLVMDIARRNKLPRIMRCCQITGRSEQDELSAAQILYPCMQCADIFFLKADICQLGMDQRKVNVLAREYCDDIKRKNKQIILSHRIALFQYLFWFLRSIECGEKLCRFKSLTKTNYFEMLEELDISDNQIRVLPESFRLLSKLRVFRADETALEVPPREVINLGAQVMLIWLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQR4</accession>
    <name>A0A0D2RQR4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G055400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the plant self-incompatibility (S1) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQR4"/>
    <dbReference type="Gramene" id="KJB34244">
        <property type="protein sequence ID" value="KJB34244"/>
        <property type="gene ID" value="B456_006G055400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502STNF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LALCIMY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060320">
        <property type="term" value="P:rejection of self pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010264">
        <property type="entry name" value="Self-incomp_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31232">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31232:SF164">
        <property type="entry name" value="S-PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05938">
        <property type="entry name" value="Self-incomp_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0713">Self-incompatibility</keyword>
    <keyword evidence="5 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025090874" description="S-protein homolog" evidence="6">
        <location>
            <begin position="25"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB34244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="146" mass="17652" checksum="94D52EB7788AB7F8" modified="2015-04-29" version="1">MFNLKEMLLPLTLALCIMYPLAFSISEDVLLINYHIHIINDLPLEPPTNVPSLNLHCKSKDKDLGERAMFQHQDYAWDSKINLFRTTLFFCNARWRNKKQRYFEAFRATRDEDRCLDYHFSCIWSVRYDGIYFSSDNYTWTMQYPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQW4</accession>
    <name>A0A0D2RQW4_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G058100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQW4"/>
    <dbReference type="Gramene" id="KJB34299">
        <property type="protein sequence ID" value="KJB34299"/>
        <property type="gene ID" value="B456_006G058100"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1001122at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250707" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11878" checksum="97C664850D3CD769" modified="2015-04-29" version="1">MGLSSFLRPLIVFLIFIISVLAIQITPVSAELKVSTQPQGDKRMPNPPPTPARNMLNRIHLLLIITIPNGHLLLYVWHLSLQLEYGLFHYLVQRGMMIRLSFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RS28</accession>
    <name>A0A0D2RS28_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cas1p 10 TM acyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_006G080500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. CASD1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RS28"/>
    <dbReference type="Gramene" id="KJB34729">
        <property type="protein sequence ID" value="KJB34729"/>
        <property type="gene ID" value="B456_006G080500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1699">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEVPWNP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009834">
        <property type="term" value="P:plant-type secondary cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012419">
        <property type="entry name" value="Cas1_AcylTrans_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF48">
        <property type="entry name" value="PROTEIN REDUCED WALL ACETYLATION 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07779">
        <property type="entry name" value="Cas1_AcylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cas1p 10 TM acyl transferase" evidence="9">
        <location>
            <begin position="15"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010666"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB34729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="181" mass="21529" checksum="1CAEBA7EE7ACB43F" modified="2015-04-29" version="1">MYHDKSPFSGKSILHLNRHQTEEWKGWMQVLFLMYHYFAAKEIYNAIQVFIAAYVWMTGFRNFSYYYVGKDFSLARFAQYKEKGSVIALKHIAYFLVVILVWEVPGVFEVPWNPFTFSLGYTDPAKPNFPHLHEWHFRSGLERYIWIIGMIYAYYHPTVSSDAIIFPLLVVFSGYEIMQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUX2</accession>
    <name>A0A0D2RUX2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Chaperonin-like RbcX protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G128600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUX2"/>
    <dbReference type="STRING" id="29730.A0A0D2RUX2"/>
    <dbReference type="Gramene" id="KJB35679">
        <property type="protein sequence ID" value="KJB35679"/>
        <property type="gene ID" value="B456_006G128600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799405"/>
    <dbReference type="eggNOG" id="ENOG502QRY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRTIIIS"/>
    <dbReference type="OrthoDB" id="546456at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110102">
        <property type="term" value="P:ribulose bisphosphate carboxylase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.210">
        <property type="entry name" value="Chaperonin-like RbcX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038052">
        <property type="entry name" value="Chaperonin_RbcX_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003435">
        <property type="entry name" value="Chaperonin_RcbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33791">
        <property type="entry name" value="CHAPERONIN-LIKE RBCX PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33791:SF16">
        <property type="entry name" value="CHAPERONIN-LIKE RBCX PROTEIN 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02341">
        <property type="entry name" value="RbcX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158615">
        <property type="entry name" value="RbcX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB35679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23985" checksum="FC62F99828496681" modified="2015-04-29" version="1">MVGALSVVDSHTGPCLCSTSMNLKTGGELVSQMKRKQGVGRAGWLELGSSFVDSCHDWRLSSKMIPGVVDKKSSRKARTLVVVNELGGQYEETFGDVKTQLVNYFTYKAVRTVLTQLYEMNPPKYTWFYQYVAANQPTDGKSFLRILGKENQELAERVMITRLHLYGKWIKKCDHAQIYKEISDENLELMRERLMETVVWPSDDSNTDTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RV86</accession>
    <name>A0A0D2RV86_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent protein kinase inhibitor SMR13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G128400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RV86"/>
    <dbReference type="Gramene" id="KJB35784">
        <property type="protein sequence ID" value="KJB35784"/>
        <property type="gene ID" value="B456_006G128400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799403"/>
    <dbReference type="eggNOG" id="ENOG502S7SX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PKIEGCA"/>
    <dbReference type="OrthoDB" id="1840446at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040389">
        <property type="entry name" value="SMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33142:SF8">
        <property type="entry name" value="CYCLIN-DEPENDENT PROTEIN KINASE INHIBITOR SMR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB35784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="122" mass="13615" checksum="B18AD5C8787C12EB" modified="2015-04-29" version="1">MAPTSRRGKTTRKASKPRRGHYKRKLVKPTIQKASVLEELPSNSSTITSDNLSKMEGSTTTASPCSTPKAQRFRIPEMDTCPPAPKKQRVLSNCSLQRTPVAFFSPPDLDLFFFFALRDISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S0M6</accession>
    <name>A0A0D2S0M6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_012G099600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S0M6"/>
    <dbReference type="STRING" id="29730.A0A0D2S0M6"/>
    <dbReference type="Gramene" id="KJB76617">
        <property type="protein sequence ID" value="KJB76617"/>
        <property type="gene ID" value="B456_012G099600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780091"/>
    <dbReference type="eggNOG" id="KOG2936">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDCEVNQ"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF8">
        <property type="entry name" value="AHA1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB76617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="39631" checksum="909822CD2270BFEA" modified="2015-04-29" version="1">MAKYGEGDKRWIVEERPDGANVHNWHWAETDCLPWSKMFFTKSLSDLTILDGQGNLRIKTKKVEKVDGEAYVNIRKGKVIPGYEISLSVSWEGEAKDGEGKTLLKAEGNLEIPYISDENADEDPEVKVTVKDEGPIGKALKEAMLAKGKPLVLEKVRDFVQAMAKGGPVKDELEAKKSAPKTNTTTSNSNSAAVSKEKVGVEKEPKKEVEKEGKKGFKTITMLEKFNCRAKDMYEILMDENRWKGFTQSNARISKEVGGQFSIFDGSVTGINLELQEGKLIAQRWRFGSWPDGIDSTVRLVFNEPEPGVTIIKLTHLDVPEEDRYGNATVVENTERGWRDLIFNKIRAVFGFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S256</accession>
    <name>A0A0D2S256_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G126700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S256"/>
    <dbReference type="Gramene" id="KJB77237">
        <property type="protein sequence ID" value="KJB77237"/>
        <property type="gene ID" value="B456_012G126700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB77237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="68" mass="7967" checksum="CEDDBF3C410B27E2" modified="2015-04-29" version="1">MVTRNAITSRIHSIPNTPTSRNRHSPIERRLGITYLFLIFVSFFCPHRFLLLLPSILQRCGMFVNHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S272</accession>
    <name>A0A0D2S272_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Ent-kaurenoic acid oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_004G187300</name>
        <name evidence="19" type="ORF">Gorai_015093</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes three successive oxidations of ent-kaurenoic acid giving gibberellin 12 (GA12), a key step in gibberellins (GAs) biosynthesis. GAs, which are involved many processes, including stem elongation, play a central role in plant development.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S272"/>
    <dbReference type="SMR" id="A0A0D2S272"/>
    <dbReference type="STRING" id="29730.A0A0D2S272"/>
    <dbReference type="Gramene" id="KJB25350">
        <property type="protein sequence ID" value="KJB25350"/>
        <property type="gene ID" value="B456_004G187300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791951"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051777">
        <property type="term" value="F:ent-kaurenoic acid monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016132">
        <property type="term" value="P:brassinosteroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000052">
        <property type="entry name" value="Ent-kaurenoic acid oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF199">
        <property type="entry name" value="CYTOCHROME P450 88D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB25350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0584271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="55690" checksum="1D61C16FF119EC54" modified="2015-04-29" version="1">MGLYLNILALILAVLLGTYVFVFGFLKKINEWRYVSSLGEKKHSLPPGDMGWPIIGNMWSFLKVFRSNDPDTFIYNLVKRYGRTGMYKTYLFGSPSIIVSIPETCRKVLADDEQFGLGYPLSTKQLTGKKSFHSIPNSEHKRLRRLTTAPINGHEALSMYIGYIEEIVVNSLDEWSSMKEPIELLNEIRQFTFKVITHIFLGSTAESVMGSVEKRYADLTYGMKSAAINIPGFAFYKALKARKMLVKILQGVLDERRVNDPNGKKGMIDLLMEIEDENGQKLPDEDIIDLLLMFLLAGHESSAHVAMWAILYLHNNPEILKKAKEEQEEILKNRQSTEKGLTLKDIREMYYLQKVIDETLRRASVSFCNFREAKVDVNINGYLIPKGWKVLVWNRGVHMDPQVYSNPKEFLPQRWENHQPRAGSFLPFGAGSRICPGADLAKLEISIFLHYFLLNYKLEQINPGGPIVYLPLPRPVDNCLAKVMKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2P2</accession>
    <name>A0A0D2S2P2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G195100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2P2"/>
    <dbReference type="STRING" id="29730.A0A0D2S2P2"/>
    <dbReference type="Gramene" id="KJB25505">
        <property type="protein sequence ID" value="KJB25505"/>
        <property type="gene ID" value="B456_004G195100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792034"/>
    <dbReference type="eggNOG" id="ENOG502QRIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RADIKYE"/>
    <dbReference type="OrthoDB" id="1911211at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF378">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="139"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB25505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="274" mass="30095" checksum="B6D70E8C02E56208" modified="2015-04-29" version="1">MEMYPSSNDSDLAVLDSIRRHLLGDSSDFRLDATIDCTTTTTTALPMVCRTSSFNRLYPCLTETWGALPLKENDSEDMLVFGFLRDALTVGWAPSDNSSMNLPPIKPEPQEILFEGPVRKVDRAVNTVVPAAVPAKAGHYRGVRQRPWGKFAAEIRDPAKNGARVWLGTFETAEDAALAYDKAAYRMRGSRALLNFPLRVNSGEPDPVRVTSKRASPEPSNSSSFGAENGSPKRRRKVAPSAPVVAQAGLDTGSRADIKYEVRSCRHDNQRLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2Z7</accession>
    <name>A0A0D2S2Z7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">STI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_004G201800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2Z7"/>
    <dbReference type="STRING" id="29730.A0A0D2S2Z7"/>
    <dbReference type="Gramene" id="KJB25645">
        <property type="protein sequence ID" value="KJB25645"/>
        <property type="gene ID" value="B456_004G201800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792110"/>
    <dbReference type="eggNOG" id="KOG1308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPRKYER"/>
    <dbReference type="OrthoDB" id="533763at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14438">
        <property type="entry name" value="Hip_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000112">
        <property type="entry name" value="FAM10 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3420:FF:000001">
        <property type="entry name" value="Hsc70-interacting protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034649">
        <property type="entry name" value="Hip_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45883:SF2">
        <property type="entry name" value="HSC70-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18253">
        <property type="entry name" value="HipN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="155"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="5">
        <location>
            <begin position="334"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="253"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="289"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB25645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="384" mass="42049" checksum="05040E528427CE75" modified="2015-04-29" version="1">MDAAKLNELKKFIQLCKSSPSILDDPSLSFFRDYLQSLGAKIPSSADTAADSKSKSYVVEESDEELADAGVKINIEEEEEEDEIIESDIELEGDTVEPDNEPPQKMGDPSVEVTDDNLDASHSAKAKAMDAISEGKFEEAIENLTQAILLNPTSAIMYGTRASVYIKMKKPNAAIRDANAALEINPDSAKGYKSRGIARAMLGQWEDAAKDLHMASKLDYDEEIKNWLKKVEPNAHRIEEHRRKYDRLHKEREDRKIERERRRRRAQAQAEYEKAKKQEQSSSSRKPGGMPGGFPGGMPGGFPGGMPGGMPGGMPGGMPGGMPGNVDFSKILSDPELMAAFSDPEVMAALQDVMKNPANLAKHQANPKVAPVIAKMMSKFAGPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S4W9</accession>
    <name>A0A0D2S4W9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G237200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB26325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S4W9"/>
    <dbReference type="Gramene" id="KJB26324">
        <property type="protein sequence ID" value="KJB26324"/>
        <property type="gene ID" value="B456_004G237200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26325">
        <property type="protein sequence ID" value="KJB26325"/>
        <property type="gene ID" value="B456_004G237200"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG4727">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDHRRKW"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000491">
        <property type="entry name" value="zinc finger matrin-type protein 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
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        <location>
            <begin position="130"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB26325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="202" mass="23469" checksum="036863A3904D3584" modified="2015-04-29" version="1">MAANNNTLGVDNTFRKKFDREEYLERAREREKQEAEGRNKSKAKGPPVQRKPLKHRDYEVDLESRLGKTQVVTPVAPLSQQAGYYCSVCECVVKDSANYLDHINGKKHQRALGMSMRVERASLKQVQERFEQLKKRKPPGSFTEQDLDERIIKQQEEEEERKRQRRERKKEKKKEKAAEEEPEIDPDVAAMMGFGGFGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7Z0</accession>
    <name>A0A0D2S7Z0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G0003003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7Z0"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB27370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="16" mass="1808" checksum="6AE1626B7D8B22FD" modified="2015-04-29" version="1" fragment="single">KTKVSLLWTSAIHINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S8Z8</accession>
    <name>A0A0D2S8Z8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inactive heme oxygenase 2, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G275400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heme oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S8Z8"/>
    <dbReference type="STRING" id="29730.A0A0D2S8Z8"/>
    <dbReference type="Gramene" id="KJB59737">
        <property type="protein sequence ID" value="KJB59737"/>
        <property type="gene ID" value="B456_009G275400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59738">
        <property type="protein sequence ID" value="KJB59738"/>
        <property type="gene ID" value="B456_009G275400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59741">
        <property type="protein sequence ID" value="KJB59741"/>
        <property type="gene ID" value="B456_009G275400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770093"/>
    <dbReference type="eggNOG" id="KOG4480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLEGEWM"/>
    <dbReference type="OrthoDB" id="652091at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010024">
        <property type="term" value="P:phytochromobilin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016951">
        <property type="entry name" value="Haem_Oase_decyc_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35703">
        <property type="entry name" value="HEME OXYGENASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35703:SF1">
        <property type="entry name" value="INACTIVE HEME OXYGENASE 2, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF030219">
        <property type="entry name" value="Heme_Oase_decyc_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB59738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="37414" checksum="605E1E96D96CD86A" modified="2015-04-29" version="1">MMRLSCFCQHLSMDSAFKSPIFHPTASFSHSQVSFPFFSFQAQYLSLNKPPTILRCSNSSTISSTTNGNNNNMAGLPVKKKRKRYRKQYPGENEGITEEMRFVAMRLRNIKGKKVSSDSVSDSETDTENNPSDQEKDDSETVKSGENGSGGEAETWSPTMEGFLKYLVDSKFVFNTIERIVDESDDVAYAYFRKTGLERSAGLSKDLEWFSQRDLVVPEPSNPGVSYVNYLKELAEKSAPLFLSHFYNIYFSHIAGGQVIARKVSDQLLEGTELEFYKWEGDVQESLKDVRKNLNMLGEHWSRDDRNKCLKEAAKSFKFLGQIVRLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SIP8</accession>
    <name>A0A0D2SIP8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G448200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SIP8"/>
    <dbReference type="STRING" id="29730.A0A0D2SIP8"/>
    <dbReference type="Gramene" id="KJB62998">
        <property type="protein sequence ID" value="KJB62998"/>
        <property type="gene ID" value="B456_009G448200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CETENCF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF46">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002264046" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="14">
        <location>
            <begin position="19"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="978"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="15">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB62998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1038" mass="114714" checksum="E5B6746A47C2F991" modified="2015-04-29" version="1">MASYLFLCLFLFFPHLYASSSGSHSCSHPEAASLIQFKNSFSITQTEDAFFYCDEIAGLKSYPKTNSWKEGTDCCSWDGVTCDHLNAHVIALDLSCSWLYGNFPSNTTLFLLPHLQKLNLAYNDFNLSRIPSEFGRFTSLLYLNLSRTGFAGEVPSQVSRLSKLVSLDLSALIYVHEQFTIDKHDLKGLVHNLSEVRHLFLDGMDMSSVNAHVFMNLSSSLRSLSLAYCDLQGKFPKNIFELPNLNLLNLGGNPVLNLDPLKLNRSNNLEHLDLSWMSPTTEFIDSVDNLQALKYLDLSGNFFFQGLSVSITNLSSLEQLIISGANDFGGLPDLMGNLVSLKFLDLSFSDLSGPVPISLGNLLQLTYLDLSGNKLSGQIPLSILNLTQLEYLEISNNCLEGSIPDDVTAFPNLISLALSDNLLNGTLPSWLYAAPSLKTIDLSQNQFSGHIKEFQSKSLELIRLENNKLQGPLPSSISQLLNLTGLSLSSNTLSGVIEFSMFSNLPNLKYLDLSYNSLSLTSNTTSTINLTRLFLSSCNLSEFPQFLKGLKSLESLDLSCNKIEGKIPQWMQEVGNGSLTYLNVSHNSLTEVEHFPWKNIAVLDLSSNLIRGNLPIPASTIDVFLISNNSFNGEVSSVICNVTSLRILDLSHNNLSGTIPQCFGNLSNSLEFLNLKKNKFYGTIPPTFAKGCRLSNFNLNGNLLEGPLTPSILNCNGLEVLDLGNNKINDTFPHWLGSLPQLQVLVLKSNHMRGSLCVNSSKSSPFFSKVQIFDLSSNYFSGPLPVRYINSFKAIINLEKIGIIESYMGVNDPGGRGFYTYSIGIVMKGQYMELVKIFTMWMIIDLSNNQFEGCIPEVFGKLNLLKGLNLSHNNLNGGIPTSIGNLTSLEWLDLSSNSLSGRIPNRLVDLPFLSSFNVSENQLHGQIPQGKQFNTFGNDSYEGNKGLCGFPVSKGCNIIKPAPPNVLEKDGSKSNIAFGWKVGLIGYGCGVVFGMSVGFVVFQTGKPKWLVNLVENQQEKRRRRKSNKGNRSNRRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJA5</accession>
    <name>A0A0D2SJA5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G4199002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJA5"/>
    <dbReference type="STRING" id="29730.A0A0D2SJA5"/>
    <dbReference type="Gramene" id="KJB63203">
        <property type="protein sequence ID" value="KJB63203"/>
        <property type="gene ID" value="B456_009G4199002"/>
    </dbReference>
    <dbReference type="OMA" id="QPRECET"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001283">
        <property type="entry name" value="Eukaryotic translation elongation factor 1 alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB63203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="86" mass="10001" checksum="0D9CA32577534F4C" modified="2015-04-29" version="1" fragment="single">MGKEKVHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKE2</accession>
    <name>A0A0D2SKE2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Filament-like plant protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G005400</name>
        <name evidence="6" type="ORF">Gorai_006870</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SKE2"/>
    <dbReference type="STRING" id="29730.A0A0D2SKE2"/>
    <dbReference type="Gramene" id="KJB63542">
        <property type="protein sequence ID" value="KJB63542"/>
        <property type="gene ID" value="B456_010G005400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB63543">
        <property type="protein sequence ID" value="KJB63543"/>
        <property type="gene ID" value="B456_010G005400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772989"/>
    <dbReference type="eggNOG" id="ENOG502QU34">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KERGSEY"/>
    <dbReference type="OrthoDB" id="1926355at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008587">
        <property type="entry name" value="FPP_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580">
        <property type="entry name" value="FILAMENT-LIKE PLANT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580:SF4">
        <property type="entry name" value="FILAMENT-LIKE PLANT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05911">
        <property type="entry name" value="FPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="975"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="146"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="774"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="977"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1013"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB63543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0597054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116351" checksum="133FCB4A5C151109" modified="2015-04-29" version="1">MDRHWPWKKKSSDKAHKAAAAAATTTVDAAANVAAPAAAQGNEDVPKKPKYVQISVESYSHLTALEDRVKLYDERVRSLEEEIKDLNEKLDAANSEISTKEDMVKQHAKVAEEAVSGWEKAEAEALALKNHLESVTLSKLTAEDRASHLDGALKECMRQIRNLKEEHEQKVQDVVASKNKQCEKIKLEFEARISNLDQELLKFEADNAAITRSLQERSNMLVKISEEKSRAEAEIELLKGNIESCEREINTLKYEIHVVSKELEIRNEEKNMSMRSAQVANKQHMEDVKKIAKLEAECQRLRGLVRKKLPGPAALAQMKLEVESLGRDYGDTRLKRSPVRPSTPHLPAVSEFSLDNVQKFQKENEFLTVRLLAMEEETKMLKEALAKRNSELQASRSLCAKTSSKLQSLEAHLSRSPSKAEVYSSQNASTPPSGTSVSEDGNDDDRSCAESWATALVSELSQFKKEKGTDTPNKNENSKHLDLMDDFLEMEKLACSSNDSTTNGAINISGCTNDKVSETVNGDASGEITCKEPDVDELPAMKLRAKLSMVLESISKDADVQKILEDIKCAMQDSENGVLEQLHDSDVTCSDQACPGDASLTAEKEIAMSAGDKLTSENVQTLSRDLAAAVLQIHDFVLPLGDEARAVDDISFDGNGLSHKIGEFSVTYNKVLCGNVSLDDFVLDLSSVLVRASELRFNVLGYKGNEVEINSPDCIDKVALPENKVTQNGSLGGIYENGCAHISSPTSNPEVPDDGNLVSDFESKQLSKFSLEEFEELKLEKESLAMDLSRCTENLEITKSKLHETELLLTEAKSQLASAQKSNSLAETQLKCMAESYRSLEKHAEELATELNIFRVKTETFENELQDEKKGHHDALARCKELEEHLQSKEICSVCSSAANIDRTSKQEKELAAAAEKLAECQETIFLLGKQLKAFRPQTETKGSPYNERIPGFHEDETVTSSINLHDLNQAEIETAGSGNASRSCAESPMESSFNTPCSPSDTEANLLRSPINSNNSNHRSTMSSSESSSSTPTPEKQSRGFSRFFSSKAKNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKT7</accession>
    <name>A0A0D2SKT7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G268900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SKT7"/>
    <dbReference type="STRING" id="29730.A0A0D2SKT7"/>
    <dbReference type="Gramene" id="KJB83872">
        <property type="protein sequence ID" value="KJB83872"/>
        <property type="gene ID" value="B456_013G268900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF136">
        <property type="entry name" value="ABC TRANSPORTER F FAMILY MEMBER 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB83872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45214" checksum="3A2B9514DD273E8E" modified="2015-04-29" version="1">MVSDARKKKAAQKKADNGVDNVSDGDSALQISDRTCTSDLCSHPVSRDIRIESLPVTFHGHDLILSHTTLLRYYSVERDYSQDRHDPFLHHLLSVIKPTHLFGSLEDVLFIPLICNNVNFNNAANPFSIARFIMNDALVQGLLDCMDAKNSKWRTVPLPHETLGRPFWLLDWRLNQAYAWFPQEGHFSKEDLIAAQILGIPCTPRLGPCEVDDWQFFAGNALPAQLNVANYKRATPRRFYGAAERYGLLGLNGCGESTLLAAIELPELPVPEHMDIYHLTREIEASDMSALEADDGDGEQLERIYERLDAMDASTAEKLAAEILFGLGFNKMMQEKKTRLGNTIDSLAEALNEWDIGGLVLVSHDFRLINQVAEEIWVCENQTLTRWEGNIMDSKAQATSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMD7</accession>
    <name>A0A0D2SMD7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G182100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMD7"/>
    <dbReference type="STRING" id="29730.A0A0D2SMD7"/>
    <dbReference type="Gramene" id="KJB43066">
        <property type="protein sequence ID" value="KJB43066"/>
        <property type="gene ID" value="B456_007G182100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801013"/>
    <dbReference type="OMA" id="EKKFCIE"/>
    <dbReference type="OrthoDB" id="943542at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34567">
        <property type="entry name" value="FK506-BINDING-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34567:SF7">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="165" mass="19600" checksum="EDBA388E5F8420F3" modified="2015-04-29" version="1">MSYRQRGNRRSSYYRQRITHPKPEPLPTWEKKFCIEVGAMPWERFVEAKKNLYENDKVFEWDDSAGLTAFQEAKQRFWEIYHGFPCENKLPSNVADLYIDNIDWNSKIDPELFSEIKSLTDNENEEKDNTKEIDWFSIPLEEIQATGWDEYEEPSPRLPSIVGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SR16</accession>
    <name>A0A0D2SR16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Translation factor GUF1 homolog, mitochondrial</fullName>
            <ecNumber evidence="8">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor 4 homolog</fullName>
            <shortName evidence="8">EF-4</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GTPase GUF1 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ribosomal back-translocase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_006G025800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="8"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SR16"/>
    <dbReference type="STRING" id="29730.A0A0D2SR16"/>
    <dbReference type="Gramene" id="KJB33674">
        <property type="protein sequence ID" value="KJB33674"/>
        <property type="gene ID" value="B456_006G025800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB33675">
        <property type="protein sequence ID" value="KJB33675"/>
        <property type="gene ID" value="B456_006G025800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB33676">
        <property type="protein sequence ID" value="KJB33676"/>
        <property type="gene ID" value="B456_006G025800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB33677">
        <property type="protein sequence ID" value="KJB33677"/>
        <property type="gene ID" value="B456_006G025800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798269"/>
    <dbReference type="eggNOG" id="KOG0462">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HADVFHQ"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="58"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="67"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="143"/>
            <end position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="663" mass="73619" checksum="D93557389C00757B" modified="2015-04-29" version="1">MGSLFRASKTLKPRKYLSPFYSIKNPFDSFGLSQRFCSHSRQNSKESAPIDLSRYPIEKIRNFSIIAHVDHGKSTLADRLLELTGTIKRGHGQPQYLDKLQVERERGITVKAQTATMFHKYKLHGCNDGNIDEPSTFLLNLIDTPGHVDFSYEVSRSLAACQGALLVVDAAQGVQAQTVANFYLAFESNLTIIPVINKIDQPTADPDRVKAQLKSMFDLDPSDALLTSAKTGQGLEHVLPAVIERIPPPPGSSSSPLRMLLLDSYYDEYKGVICHVAVVDGALRKGDKISSAATGQAYEVLDIGIMHPELTPTGALLSGQVGYVVTGMRSTKEARIGDTLYHTRTTVEPLPGFKPAKHMVFSGLYPADGSDFDALNHAIERLTCNDASVSITKESSTALGLGFRCGFLGLLHMDVFHQRLEQEHEAHVISTVPTVPYIFEYSDGSKVEVQNPAALSSDPKKRVTACWEPTVIATIIIPSEYVGPVITLCSERRGQQLEYSFIDSQRAFMKYRLPLREIVVDFYNELKSITSGYASFDYEDSEYQQSDLVKLDILLNGKPVDAMATIVHSLKAQRVGRELVDKLKKFIDRQMFEIIIQAAIGSKVIARETISAMRKNVLAKCYGGDVTRKRKLLEKQKEGKKRMKRVGSVDIPQEAFHQLLKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSN6</accession>
    <name>A0A0D2SSN6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G139900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSN6"/>
    <dbReference type="SMR" id="A0A0D2SSN6"/>
    <dbReference type="Gramene" id="KJB66433">
        <property type="protein sequence ID" value="KJB66433"/>
        <property type="gene ID" value="B456_010G139900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774438"/>
    <dbReference type="eggNOG" id="ENOG502S19D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEWCRCT"/>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000820">
        <property type="entry name" value="RNA recognition motif-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF37">
        <property type="entry name" value="BINDING PARTNER OF ACD11 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB66433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="302" mass="31947" checksum="1309FCF2614A5537" modified="2015-04-29" version="1">MATQSVKVGNVSLGASEKDLKEFFSFSGEIAYVEMNGDNEQSQVAYITFKDSKGAETAVLLSGATIVDQSVTIELAPDYKPPASATLATENKGSANAESAVQKAEDVVSDMLARGFILGKDALNKAKTFDEKHGLTSTATATVASLDEKIGFTEKINVGTTIMNEKVREMDQKYQVSEKTKSALTAAEQTVSNASSALMKNQYVLTGATWAMGAFNKVAKAAGDVGQKTREKVLAEEQAKNPEGNAQVNEAESVKAAEPAEGGKQPSNPPSTQDKVVGEQQAQKPEGNAEIKEAESIKVTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SST1</accession>
    <name>A0A0D2SST1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein PsbN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G061700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SST1"/>
    <dbReference type="STRING" id="29730.A0A0D2SST1"/>
    <dbReference type="Gramene" id="KJB34355">
        <property type="protein sequence ID" value="KJB34355"/>
        <property type="gene ID" value="B456_006G061700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042170">
        <property type="term" value="C:plastid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00293">
        <property type="entry name" value="PSII_PsbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003398">
        <property type="entry name" value="PSII_PsbN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35326">
        <property type="entry name" value="PROTEIN PSBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35326:SF3">
        <property type="entry name" value="PROTEIN PSBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02468">
        <property type="entry name" value="PsbN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB34355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="43" mass="4893" checksum="573F217104170D8E" modified="2015-04-29" version="1">METATLVAISIFVLLVSFTGYALYTAFKLPSQQLRDPFEEHED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXG0</accession>
    <name>A0A0D2SXG0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G088700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXG0"/>
    <dbReference type="STRING" id="29730.A0A0D2SXG0"/>
    <dbReference type="MEROPS" id="M03.A01"/>
    <dbReference type="Gramene" id="KJB48824">
        <property type="protein sequence ID" value="KJB48824"/>
        <property type="gene ID" value="B456_008G088700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045666">
        <property type="entry name" value="OpdA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF83">
        <property type="entry name" value="LD37516P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19310">
        <property type="entry name" value="TOP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Oligopeptidase A N-terminal" evidence="9">
        <location>
            <begin position="139"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="342"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF19310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB48824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="457" mass="51599" checksum="7A68506E8E557770" modified="2015-04-29" version="1">MRLIRHIPNRVLFNTIFVSVNILMASTRFSLSRSVQPILKRPPFSSSPRFAPKALLKSYPCPLWSSSFSFCLQTLHHSTSPYLSSSSSSSSFSSCSSFSPPSMASSFTVDDSIGSNPLLQDFDFPPFDIVEAKHVRPGIRALLKKVESDLDELENTVEPSWPKLVEPLEKIVDRLTVVWGMVNHLKAVKDSAELRAAIEEVQPEKVKFQLRLGQSKPIYNAFKAIKESPDWQSLSEARKRIVDAQIKEAVLNGVSLEDDKREQFNKIQQELERLSHKFSENVLDATKKFEKLVTDKKEIDGLPATALGLAAQTAVSKGHENATAENGPWMITLDAPIFISAMQHARNRALREEVYRAYITRASSGDLDNTPIINQILKLRLEKAKLLNYNNYAEISMATKMATVDKAEELLEKIRSASWDAAVQGIMLNLVYFWLKRLPIFRSLIYHMNLFPQCLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZL9</accession>
    <name>A0A0D2SZL9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G032800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SZL9"/>
    <dbReference type="Gramene" id="KJB47596">
        <property type="protein sequence ID" value="KJB47596"/>
        <property type="gene ID" value="B456_008G032800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTFSFMH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000525">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000755">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF386">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB47596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="52610" checksum="0DD43A23EC7666D4" modified="2015-04-29" version="1">MSFNSITKFLQTCSQIKSLIATKILHAALLRKGLFFVSPNIHSELIFTYAACLESKTIIKILTNYFKSINPPNPLPFNVIISDFSKNGFSFFALKTFSFMHFNGISLDTYALCSSISASSSLKKAEFGKQIHCHVTKSGWTSSVFVGSALVDLYAKSSLIADAAVMFDEIPFKNSVCANALLSGFCEAKLWIQGLVLVRKMPGLNLDYDHFTSSAMLRACAGLSAIELGRQVHGYLFRKFYNLVEDVFLQSSLIEMYGKCGLVMKAFQVFSLAGLRLGREKRRDVVLWTSMLGVYGRNGHYEDLILLFKEMLREGIKPDEVAFVTVISACGHTGQIRLGLEYFDSMTHVYKLIPGPEHYSCVVDLLCRAGELEKAMKVVNEMMLQKGHNNGSVSLWVALLSACSDHENVELGKFAAQKALELDPQNVGVYVKLSNLYARLRMWDEIGQLRETMKQRGLKKDTAFSWVEVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T349</accession>
    <name>A0A0D2T349_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G059000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T349"/>
    <dbReference type="STRING" id="29730.A0A0D2T349"/>
    <dbReference type="Gramene" id="KJB70123">
        <property type="protein sequence ID" value="KJB70123"/>
        <property type="gene ID" value="B456_011G059000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777610"/>
    <dbReference type="eggNOG" id="KOG1571">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWPQSDY"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23145">
        <property type="entry name" value="RING-HC_SPL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022170">
        <property type="entry name" value="MUL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044247">
        <property type="entry name" value="SPL2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47355:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SPL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12483">
        <property type="entry name" value="GIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="334"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB70123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="386" mass="43142" checksum="B73888E0D19DA01E" modified="2015-04-29" version="1">MSSHEQAVASLISQLALSFDGAVLGAALAYAALRTIFRFKATSTALRKIRGAPYFRVADLRSLLEEDRSDSHEEPIVVIRGAVEARSATDLRSLKSLKSNVLVSQESGDKAVIIQRTQTYIYHEWRGLFGWTSDLRAIIGRSWNKKESTSMRTVPFILVEGGQWPQSDFVIVNMNGSKHPLPLTTVYHQLHPINASPYTFLQALFGHEYPVGLLDEEKILPVGKEISAVGICGFSNGVPEVKACKELPYFLTDMTKDQMLLDLAFKTKILFWSGVVLGSLSIGILGYAFVRNWNKWKERRLRRFQQAANAATDDSTLQMDLDEELGDVPDGELCVVCLMRRRRSAFIPCGHLVCCQHCAVSVERELVPKCPVCRMAIRSSVRIYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TAC9</accession>
    <name>A0A0D2TAC9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_011G190700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TAC9"/>
    <dbReference type="STRING" id="29730.A0A0D2TAC9"/>
    <dbReference type="Gramene" id="KJB72688">
        <property type="protein sequence ID" value="KJB72688"/>
        <property type="gene ID" value="B456_011G190700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB72689">
        <property type="protein sequence ID" value="KJB72689"/>
        <property type="gene ID" value="B456_011G190700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777398"/>
    <dbReference type="eggNOG" id="KOG0246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PFIPKEM"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903338">
        <property type="term" value="P:regulation of cell wall organization or biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="203"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="607"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="724"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="665"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="687"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="292"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB72688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="807" mass="89870" checksum="CFAAFCB492A01307" modified="2015-04-29" version="1">MQQSNAAATALYDHAGVGSLHNAGPTGGDAGDAVMARRLQSAGLQHLASPLASTGIDQRLLPNLLMQGYGAQSTEEKQRLFKLMRNLNINGESGLEPYKPTAQNSGGPAASDGFYSPEFRGDFGAELLDLHAMDDTELLSEHVTSEPFEPSLFIPGVNKAFENDFNATTNWQQKEQSDADASASLFSANEKEISSTRENNVAKIKVVVRKRPLNKKEISRKEDDIVTVSENALTVHEPKLKVDLTAYVEKHEFCFDAVLDEHVNNDEVYHATVEPIIPIIFQRTKATCFAYGQTGSGKTFTMQPLPLRAAQDLVRFLHQPIYRNQRFKLWLSYFEIYGGKLFDLLSDRKKLCMREDGRQQVCIVGLQEFEVSDVQVVKEYIERGNSARSTGSTGANEESSRSHAILQLVIKKHPEIKESKRNNDVNESKAGKVVGKISFIDLAGSERGADTTDNDRQTRIEGAEINKSLLALKECIRALDNDQIHIPFRGSKLTEVLRDSFVGNSRTVMISCISPNAGSCEHTLNTLRYADRVKSLSSSRSGNPKKDQTVNSLPPSNRDVSSLSLLATADVEDVYERQPEVEVVDTGRRPVEKDVYTFDFDKQPSTFIGREESGMASGPTDREKIEVNNSYGGSRSLRVYSSNSQNSADMEEKVRKVSPPRRKVTREEKPEKMGNRTKKDGGGSDLSTQNSMQSNSNNHNSTNDVGRRRYNPEPPTDGNINAILEEEEALIAAHRKEIEDTMEIVREEMKLLAEVDQPGSLIDNYVTQLSFVLSRKAAGLVSLQARLARFQHRLKEQEILSRKRVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TD72</accession>
    <name>A0A0D2TD72_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G110600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TD72"/>
    <dbReference type="STRING" id="29730.A0A0D2TD72"/>
    <dbReference type="Gramene" id="KJB41583">
        <property type="protein sequence ID" value="KJB41583"/>
        <property type="gene ID" value="B456_007G110600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41584">
        <property type="protein sequence ID" value="KJB41584"/>
        <property type="gene ID" value="B456_007G110600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41585">
        <property type="protein sequence ID" value="KJB41585"/>
        <property type="gene ID" value="B456_007G110600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802819"/>
    <dbReference type="OMA" id="ISNDCYP"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="274"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="378"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="418"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB41585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="754" mass="83368" checksum="BC09CD9298D1A50C" modified="2015-04-29" version="1">MMGSLTEEEDQFFDTREDITSVSDSGSDCPENSDSEHATSINSVPSNVGFEIWVKNPSSIRERRDKFLKWMGLSIDQIAREGASNVWCDEIEVETDRILEKSGAALGSSSFNDGCSSSQSSVSCSSSDARELLDRALDDNLVCRIKNLDDGTEFIVDELSQDGKFRKLREVGSNHLLTVNEFERKLGLSPVIQQAMRREVKDVSDLGPERKQGKRGWLRRLGTVACVVDRQVESACTISNDCYLNAEARIQLVRVRSYKKRSKEFSALYKGQEIQAHEGSILTMKFSPDGQYLASAGEDGVVRVWQVLESELSGNSDIHDVNPSCVYFTVNNFSELVPLHVDKEKNGKSKRVKKVSGSTCVVLPQKVFRILDKPIHEFRGHCGEVLDLSWSKSKHILSSSVDKTVRLWQVGYDECQKVFSHNNYVTCVQFNPVDDDYFISGSIDGKVRIWVIPGCQVVDWIDVTDIVTAVCYRPDGKGAVIGSINGDCRFYDASDNHLQLKAQICLQSKKKSACSRITGFQFAPGDPDKLMVTSANSQVRILHNVDVVCKFRGLRNAGSQISASFTSDGMWIVSASEDSNVYVWNNISQDGLVPQAKNNWSCERFFSNNASVAIPWCGMTSINSIFSTMAGGMPSPKVSSSTWTCNGNAGVLQSESGESSLHKSPFSTSERSSLGHGFFSESLSRGTATWPEEKLPPPNSLVVSSAMCKSHYKLLKTSCQSALDSSHSWGLVIVTAGWDGRIRSFQNYGLPIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TET3</accession>
    <name>A0A0D2TET3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexosyltransferase</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_007G142400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2 13">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TET3"/>
    <dbReference type="STRING" id="29730.A0A0D2TET3"/>
    <dbReference type="Gramene" id="KJB42215">
        <property type="protein sequence ID" value="KJB42215"/>
        <property type="gene ID" value="B456_007G142400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803158"/>
    <dbReference type="eggNOG" id="ENOG502QT8Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DSENNHD"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000056">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF0">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25557">
        <property type="entry name" value="GAUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="93"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="597" mass="68816" checksum="56C468260AE62897" modified="2015-04-29" version="1">MKKCHRWQRILILSLLSFSVFAPIVLVSQRLKTLTSFGGKEFAEDLPSVNYMRDVLRLNSIEQEAAEGLKGPKLVVFNDKDISSVVRRSSYEDRDSDQFRNAQDDSKLLEANETNGNGKDEHQIQQTIIQMNSREKGQFNQEKGRDDQRLQSPFNVVDEKVKQMRDQLITAKAYLSFEPPGSNSRLMKELRARIRELERVVGEVSRDSDLPMSASQKMRSMELSLAKASRVFPDCSAMATKLRAMAYNAEEQVQVMRNQESHLLQLAGRTTPKGFHCLSMRLTAEYFLLRPEERQFPNQQNVNDPDLYHYAVLSDNVLAASVVVNSTISSAKEPEKIVFHVMADSLNLPAISMWFLLNPPGKATIHVQSIENFDWLSTKYNSTLNEQKSYDPRYSSALNHLRFYLPDIFPALNKIVLFDHDVVVQRDLTEIWSIDMKGKVNGAVETCLESEASFRSIRMFMYFSDPFLARRFNANVCTWAFGMNLFDLHEWRRKNLTMLYRNYLQLGLKRSLWKGGSLPIGWITFYNQTVALEKRWHTLGLGYNSDVPPGDIENAAVIHYDGVMKPWLETGIAKYKGYWSKHLLHDHPYLQQCNIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TG97</accession>
    <name>A0A0D2TG97_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G008100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0593882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TH02"/>
    <dbReference type="Gramene" id="KJB53851">
        <property type="protein sequence ID" value="KJB53851"/>
        <property type="gene ID" value="B456_009G007800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767599"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FELAYIL"/>
    <dbReference type="OrthoDB" id="1938353at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057291">
        <property type="entry name" value="CHX17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468">
        <property type="entry name" value="CATION/H + ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32468:SF17">
        <property type="entry name" value="CATION_H(+) ANTIPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23256">
        <property type="entry name" value="CHX17_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="72"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter central" evidence="12">
        <location>
            <begin position="505"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB53851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0593882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="792" mass="88628" checksum="E8E9D68B03FE953C" modified="2015-04-29" version="1">MAYSNSGSYTTGNSTKSEAQVCLKFPPKVSSPGLMALWSAKGQNKGKLRMLMEYSGPRLQIQMVVTFVLTQAIHSVLKHLRLPMFISQILAGMILGPMVFRGKRSLITSSDQSVAVLGTVGAIGYMFFLFLSGVKMDVGMTFRSGKKVICIGVLTVVVPLMACLITAKSLNQESQFFTNKRVFLAVTYSATSFPVIHCLLSELKLLNSELGRLGLSAALIGEIVALFLLTICQWVVDGLENGWKVVVSNFGFFTVYFVIVVFWFRPVMKWMVRKTPEGGQIKNSYLYIVIGAFMVSHKLAELLKVYIVFAPFLVGLAVPDGPPLGSALVEKLEPIVEGLFMPLFVTTCGMRIDFSYLKNYGSFAKDQVISAVVTNFVKFGVSFLLPFLWNIPIRDSLAFAFIMLNKGIVEMASYSFMNDTLVISQDMFAFVTIIVILIASIVPIFVKTLYDPSSKHVRYLKKSIMDCKLNDELRIIGCIHVPANVNSIIDILNASCPTRQSPIALSVLHLIKLSGRATPLFIAHEKQSKSPSNNSYSENVVLAFNRLERDNWGAVSVKSFTAVSPPNLMHEDICNLVMDQFTSFLILPFHRRRHVDGSIESEDQTVRRLNFNILQKPPCSVGILVEGQRHVKCINSRDHMHDQYPLANSSTYTIAMIFMGGKDDWEALALAKRMSRDKSVKLTVIQFKAVDGFQDDDGDRMMDKQLLRNVKENTSTTYIEKEVKDGPETLTYLRSIVDDYKLFIVGRRYKREDPQTVGLHEWSEFQDIGIIGELLSSPDFGGKHSVLIVRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZJ7</accession>
    <name>A0A0D2TZJ7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G084300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZJ7"/>
    <dbReference type="Gramene" id="KJB48750">
        <property type="protein sequence ID" value="KJB48750"/>
        <property type="gene ID" value="B456_008G084300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF450">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB48750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="189" mass="21987" checksum="6EF480EEA569C879" modified="2015-04-29" version="1" fragment="single">WLQSHPKYDSNPLYVAGDSYSGMIIPKCYNFSSNYCSLLLGNPFTDAKFDGNSKIIYYNQMALISDELYESAKSNCKQEYIDVEISNRMCAKDLQTISVTRLITVLAFAFLMHCTYKLVRKYLLETREDFLHLSAEYPQFGCRNYYCYLCKVWATDINVQKALHIRKGSIKQWVKCNKSMDYDDDVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZV0</accession>
    <name>A0A0D2TZV0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-structural maintenance of chromosomes element 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G346200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the SMC5-SMC6 complex.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="1">Belongs to the NSE4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2TZV0"/>
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        <property type="gene ID" value="B456_009G346200"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027786">
        <property type="entry name" value="Nse4/EID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16140:SF18">
        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="29"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="201" mass="22519" checksum="BC121D6FB8B74012" modified="2015-04-29" version="1" fragment="single">MVRNVNKEKQTGKGDASAEPVRTKVAGVARDESTDVELNKPNREEDAADRRVLRSKYLVVMTKISDAREEISNVDSNKFNIIINEVDNLHQQVSKPREQVADAEALLGLTNTLATSVKSLETQENEQISIDWKEIGVAVSPFFRTCKGICTMLGPMSNELRQRKSMVTRKRAVRPTDTSRPDEVDETGVEEKTDTDRNMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U059</accession>
    <name>A0A0D2U059_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">DUF4283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B456_009G414700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2U059"/>
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        <property type="gene ID" value="B456_009G414700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLENDYC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
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        <property type="entry name" value="DUF4283"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF99">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14111">
        <property type="entry name" value="DUF4283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB62389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="417" mass="46817" checksum="A161E39B92DADD63" modified="2015-04-29" version="1">MEFGNGRRSAKTIRQRLEDPLDLDNPIVNDKCMKAVSICVRMVSWKYKLLGATAERINLQNEEDFELLKGEAEKEIIDDILSITFFERPLKVIGLENDYCSVNFQDDDEYLHAVSGGPWTIFGQYLTVRPWTPSFTTDQDFPTSLLVWIRLPGLWEGMYTRSLLKFIARAIGRLARLAVYIDLGKLLVPKLQIDKRVQCVEYETIPLVCFRCGRFEHSSDACLHRTEKKETIEGVTVENLDNDTTAQGGAADWSSNKDAMTHSSDKGDQFGPWMLVERKLHWTPLTAMKPIVNSIDEVEEVKSAALNGSTGIKGSDKGILGKALPVRGKLLSNPQIKTKVFKKGSEKNKCKVVVLMNGSKTNSNVLKPVNNQRSSFRPIDNPFNDGSKMGLKLLNNGSDPIRFRAVGHGLDKGEICY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U953</accession>
    <name>A0A0D2U953_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G093400</name>
        <name evidence="9" type="ORF">Gorai_007481</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U953"/>
    <dbReference type="STRING" id="29730.A0A0D2U953"/>
    <dbReference type="Gramene" id="KJB65399">
        <property type="protein sequence ID" value="KJB65399"/>
        <property type="gene ID" value="B456_010G093400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773797"/>
    <dbReference type="eggNOG" id="KOG1361">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="260"/>
            <end position="323"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="14"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="384"/>
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            <begin position="24"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="6">
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            <begin position="58"/>
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            <begin position="169"/>
            <end position="185"/>
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            <begin position="397"/>
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="PROSITE" id="PS50105"/>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="752" mass="84076" checksum="B4376C00A1F0D12E" modified="2015-04-29" version="1">MLSRSTASQLIYAASGDDDDFQIPPTQTLSASLKPNSHKTPLKPSNPPHPSFKKRNHAANSGKENAVVSTVPATRSDDLPVLRDICGLDLIPSSIDSSFDSTSAQNKESDTVKCDEKKMESLELTKGYMCNSVESRLIRPISELSEGFCEVCEEDEELDELLKLCDEVEEKEEETSREEEEDNGIEQERNAEDNGSVPCPLCGVDISNLNEEQRLVHTNGCLDKVENPPPKVVIPSSVDSELHSLPEVVDGPLLSPRQVVDVSPVVNWLSGLGLAKYAAAFVQEEVDWDTLKWLTEEDVFSIGVTALGPRKKIVHALSELRKGGSCAAEPHLDHPKHEKGSAKSNKRKMQTKLSNVADDETTKPAANKLITDYFPGYVSDRKKVCTPTRGQNRSDKGQSSAGRRPVQKNNVKNGKLKDIPSWCCIPGTPFRVDAFKYLRGDCSHWFLTHFHMDHYQGLTKSFRHGKIYCSSITARLVNLKLGIPWAMLQVLPLNEKINISGIYITCLDANHCPGSIMILFEPPNGKAILHTGDFRYSEEMGGLSLLHACPIHTLILDTTYCNPQYDFPKQVAVIQFVIEAIQAEAFNPKTLFLIGSYTIGKERLFLEVARVLRRKVYITAAKLRLLECLGFSKEDMQWFTSNDQESQIHVVPMWTLASFKRLKHISNHYARRFNLVVAFSPTGWTFGKGKKKSPGRRWQQGTIIRYEVPYSEHSSFTELREFVKLVSPENIIPSVNNEGPDSAKAMISHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9C8</accession>
    <name>A0A0D2U9C8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Intracellular protein transporter USO1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G251400</name>
        <name evidence="4" type="ORF">Gorai_010409</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9C8"/>
    <dbReference type="STRING" id="29730.A0A0D2U9C8"/>
    <dbReference type="Gramene" id="KJB52230">
        <property type="protein sequence ID" value="KJB52230"/>
        <property type="gene ID" value="B456_008G251400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765272"/>
    <dbReference type="eggNOG" id="ENOG502QSIG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYQFDKS"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043424">
        <property type="entry name" value="BLT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071:SF59">
        <property type="entry name" value="INTRACELLULAR PROTEIN TRANSPORTER USO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB52230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0593466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="680" mass="77563" checksum="D98320ACB3F88B2D" modified="2015-04-29" version="1">MKREEKSEEGLAEKEENLCEKLSRRILLVGNSKTEGPCTPCPSWKLYDPQPQPQALSHHSYIFPRPPAAVSARKLAASLWEFHQYLHHHHHSQPKMHRGGFNNTNGRYHQRHHRNSLLKNKAIDFSQFLDDPCPSSDPDQPESASGLRRHIAQTLMKHHRSFEKNNQALQPVSPSSYGSSMEVAPYNPAVTPSSSLDFRGRIGESHYNLKTSTELLKVLNRIWSLEEQHVSNISLIKALKMELDHARVRIKELLRDQQAGRHEIDNLMKQIAEDKLVRKSKEQDRVHAAVQSVRDELEDERKLRNRSENLHRKLARELSEAKASLSNALKDLERERKSRKLLEDLCDEFARGIKSYEQEVHTLRQKSDEEWTGVADHDHLILHISESWLDERMQMKLEEAQSGFAEQNPAIDRLGFEIETFLQAKSIGTSVSKRTDYLSQKDRRKSLESVPLNEAVTVGKDVLDEEDSASSDSNCFELNEPSSVDLKSHEDEALTHYSEKKVSSDEKIKSRHPSSLQVKFEEKMARAMNNGNKKSQLEDSGQEIIGVGNTTEATISQKLENDEAAQYGYKGRKNKLDEIHGISSNYVMDNLIRNHIALTEGRNINVENNSGEASSSYPLLKNQPSPVRQWMTKFTPPDLDVPESSTKLPPAMKDNTLKAKLLEARSKGQRSRLKIFKGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9N2</accession>
    <name>A0A0D2U9N2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G099600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9N2"/>
    <dbReference type="STRING" id="29730.A0A0D2U9N2"/>
    <dbReference type="Gramene" id="KJB65544">
        <property type="protein sequence ID" value="KJB65544"/>
        <property type="gene ID" value="B456_010G099600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773562"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QEQCFVP"/>
    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000554">
        <property type="entry name" value="protein indeterminate-domain 12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000131">
        <property type="entry name" value="protein indeterminate-domain 5, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055186">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF218">
        <property type="entry name" value="C2H2-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22996">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="504" mass="55048" checksum="C5E18680E4E2095E" modified="2015-04-29" version="1">MDESMSNLTSTSGEFSASSGTVLYPPQQSFASTNQAPAAAKKKRNLPGNPDPDAEVIALSPKTLLATNRFMCEICNKGFQRDQNLQLHRRGHNLPWKLKQRTNKEVVRKKVYVCPETTCVHHDPARALGDLTGIKKHFCRKHGEKKWKCEKCSKTYAVQSDWKAHSKICGTREYRCDCGTLFSRRDSFITHRAFCDALAEESARAITGPAQQVPGGSSVSHMNNLQSQLHSHDFHGLSVKREEHPFNARPTTEDSLNPPWPGPPSINLLDHPLSQNENPSQNTGSNTLLPPFQTQTASPHMSATALLQKAAQMGVTMSQPLQSPVAAMASMQRPYMSGGTSGSTSFALSTAGSGLGLFPREDLGSGSPHGLASLGNKAAAAITSRFMEQSPTAAPNSLLHDMMCSLSTGFDGSSLFEQSFNRVWNTKGNPIDFQEPTTDHLSKAKESHSQGNNMGGNDGMTRDFLGLKAFPHRDFPNLAALNHRLNPSSRFGQQNQHSQTPWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFK4</accession>
    <name>A0A0D2UFK4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glycosyltransferases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G033400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFK4"/>
    <dbReference type="Gramene" id="KJB54425">
        <property type="protein sequence ID" value="KJB54425"/>
        <property type="gene ID" value="B456_009G033400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSAMDYP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000037">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000088">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48049:SF60">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 91B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB54425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="86583" checksum="480AB310D6C5F490" modified="2015-04-29" version="1">MDRTKKLHIAMFPWLAYGHTMPFLEVSKFLAQKGHRISYISTPKNISRLPKLPPLLSSNITFVEFSLPQVDGLPPGVESTAEVPIENVPYLKNAYDKLQGPLTEFLKNSNVNWLIHDFEPYWLPGVAAPLGINLVLFCLFNATALAFMGPPSALLGEFRKRPEEFTVVPEWIDYPCNVALKHHEIVNHIKCMDDVSDFQRMGQLIQGSQFVTTRACFEFEPDEIKLLIKLYQKPVVPVGLLPPSLPSNEDKRDDKWEATKSWLDSKGEKSVFYIALGSEVSLSEESMRQLAFGIEKSNLPFIWAVRKRPMGEGLIDNIIPPGFEERVSNRGLVLRDWAPQLRILAHSSVGGFLTHCGWSSIIEALKFGRALIVFSGASADQGLNARLLHGRKVGIEIERNEMDGSFTSDLVAKTIRQVLVEPEGEAIRANAWAMKEIFDNEELSNNYLDGFTRFIEDISFVEFSLPQIQGLPAEAESISELPIDQIPSLKKAYDKLQDPLTEFLKNSNVNWIIHDFAPYWLPRVATLLGINLVFFSTFNATSFVSMGPPSALLGDLQQRPEDFKAVPENLCNIAMKLHETVNYQQCMDDVSDFQRVGLLIEGCQVVTMRTCFEFEPDEVKLLIKVFQKPVVPVGLLPPSLQCHKTRIKEMINGCFLSHCGWSSIIGALKFGRALIVFSGASADQGLNARLLHGRKVGLEIERNETNCSFTSDLVAETIRQVMMEPKGEAIRANAWELREIFDNEELSNNCLDGFTRFIEEFAPSGCHSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UH89</accession>
    <name>A0A0D2UH89_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G223700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB68069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_010G223700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
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            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253445" description="Secreted protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="9153" checksum="DB7640280338481A" modified="2015-04-29" version="1">MFLYLFIFAFMNLIVLSFQRKLSSAFKPPFPVQNKTLIKPPTYLPHPSLSPSTQKTDCTVHKNLIKYKNAASLTSEDDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMW7</accession>
    <name>A0A0D2UMW7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">Anther-specific protein BCP1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B456_011G020900</name>
    </gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="OMA" id="MARQMIV"/>
    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252771" description="Anther-specific protein BCP1" evidence="2">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB69386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="8435" checksum="AA439698D2C9FDFD" modified="2015-04-29" version="1">MARQLVVLALVLIALTGVVSAAAPASDSKAAASSPGSSPAGAPAGASVDGNAAGSSPPSLATAPSPSGGVALEVSASTIVGVGAATVAGYVMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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    </protein>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant ACBP60 protein family.</text>
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        <property type="protein sequence ID" value="KJB69416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2UMZ4"/>
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        <property type="gene ID" value="B456_011G022600"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QQ42">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="512636at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080142">
        <property type="term" value="P:regulation of salicylic acid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
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        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046831">
        <property type="entry name" value="Calmodulin_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012416">
        <property type="entry name" value="CBP60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31713:SF18">
        <property type="entry name" value="OS02G0177800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07887">
        <property type="entry name" value="Calmodulin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Calmodulin binding protein-like N-terminal" evidence="9">
        <location>
            <begin position="90"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein central" evidence="10">
        <location>
            <begin position="249"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Calmodulin binding protein C-terminal" evidence="11">
        <location>
            <begin position="320"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB69416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66776" checksum="9B03B895801D926B" modified="2015-04-29" version="1">MAREKRCLDSMSSGDEGPAMKKPALASVIVEALKVDSLQKLCSSLEPILRKVVSEEVERALAKLGHPKLNNAKSSSSSPKRIKGHDGRNLQLKFKSKLSLPLFTGGKVEGEQGAAIHVSLIDANTGHVVTGSPESWATLDVVVLEGDFNNEDGDNWTQEEFDSHVVKEREGKRPLLTGDLQVILKEGVGTLGELTFTDNSSWIRCRKFRLGLKVASYSCEGIRIREAKTEAFTVKDHRGELYKKHYPPALNDEVWRLEKIGKDGSFHKKLNKAGIFTVEDFLILVVRDSQRLRNILGSGMSNKMWDVLVEHARTCVPSGKVYVYYPDNWRILGIVFNSIHEFSGLISNGQYCAAGSLSDNHKVYVDGLVKKAYENWMHVIEYDAKSSPGSNEDDNTGCSKANVPMDLQAYPSHHQVLPSLLVPEQPPMDSGLNVGDPMAASQLPMQSQNARLNAQTTQLNGALFTELNDNELTHHCPSHSSSKPGFHGVAASNIPPFKAEADDFLSEEEIIMRSNEVLENEDMQHLLRVINMGSHGHGASNPCSSTYMPTAPSLNCGFNKEEALSSSGKAVVGWLKLKAALRWGVFTRKKVAERLARLVELDEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UWE9</accession>
    <name>A0A0D2UWE9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_011G222200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">May function in the depolymerization of the pectin in its walls during pollen tube elongation, or in that of the pistil during pollination.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UWE9"/>
    <dbReference type="STRING" id="29730.A0A0D2UWE9"/>
    <dbReference type="Gramene" id="KJB73194">
        <property type="protein sequence ID" value="KJB73194"/>
        <property type="gene ID" value="B456_011G222200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775934"/>
    <dbReference type="eggNOG" id="ENOG502QTIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPRNINC"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000004">
        <property type="entry name" value="Pectin lyase-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253117" description="Polygalacturonase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB73194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="396" mass="42696" checksum="7776725EFFFE3E96" modified="2015-04-29" version="1">MKLSGCNFHGVIVIVFVMLRISSTSAMTNFNVLNFGANPIGRTDSTDSFLKAWNAACSTADSTFIYVPKGRYLVGSLAFKGQCKSPQIIIRIDGTIVAPSDYGVLGKWENWVSFERVSGVSIIGQGAFDAKGPSLWACKASSSNSCPLGTTTLRFTNSNNITINGLTSLNSQMFHIAINGCQNVQIQGVKIIAAGNSPNTDGIHVQLSTNVEIFNSSIKTGDDCISIGPGTKNLWIEQVTCGPGHGISIGSLAKDLEEEGVQNVTVKKTIFSGTQNGLRIKSWARPSSGFVQGVRFIDSVMRNVQNPIVIDQNYCPHSENCPGQVSGIKIKDIRYENIRGTSSTPIAIKFDCSPKNPCTEISLRNVNLTYLDKDAQSFCCNVVGKVFDLVRPNSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UWG2</accession>
    <name>A0A0D2UWG2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G211500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UWG2"/>
    <dbReference type="STRING" id="29730.A0A0D2UWG2"/>
    <dbReference type="Gramene" id="KJB73031">
        <property type="protein sequence ID" value="KJB73031"/>
        <property type="gene ID" value="B456_011G211500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEIRECG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HIG1" evidence="5">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB73031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="8795" checksum="69CEA5DFE2A963C5" modified="2015-04-29" version="1">MEAFQSWVSEHKLTSIGAVWASAIGASLAYNSRGKSTLKPSLRLIHARMHSQALTLAVLSGAAAYHYYEKSTSNQEKVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UY43</accession>
    <name>A0A0D2UY43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_011G259500</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UY43"/>
    <dbReference type="Gramene" id="KJB73894">
        <property type="protein sequence ID" value="KJB73894"/>
        <property type="gene ID" value="B456_011G259500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRMKKEQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF610">
        <property type="entry name" value="SERINE-THREONINE_TYROSINE-PROTEIN KINASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="684"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="713"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB73894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="986" mass="108643" checksum="D739A4CC84F5DB43" modified="2015-04-29" version="1">MEYMRLGSPPLDEGTDQFRGLNLLRLATASPLVRGNDTDQQALLQLKAKITGDQLNIMESWNSSIHLCQWIDVTCGRKHPRVTKLKLRVLKLSRSLSPYIGNLSFLRELNLTGNSFYNQIPQEIGGLRRLEALHLANNSISGEVPSNLSACSKLILVDMSNNQLTSEIPSLLDLLSNLKVLGFINNNLKGSIPPSLGNLSSLEKLGLEDNALSGIIPEAFGRLSNLSFFAISGNAISGIVHVPMFNLSNIRAFDIGINKIQGTLHSDLEINMLYVEFFSVMENQISRQIPISLSNATYLHVLEFSGNRFTGNVPSLEKLDKLSNLELGKNYLGHGREGDLNFLCSLFNNTKLSFLSIGKNNFGGEFPKCISNFSRTLRGLAMGENNILGKIPDGIGNLINLEVLVFSINQLSGPIPFNIGRLQKLKRFFANSNFLSGTIPHSIGNLSELIELNLNFNNLQGSIPSGLVLGLPSLSILLNLSSNYLTGELSVGVEKLKILSILDVSQNRLSGLLPKNLCSCVSLEKLFLEGNLFEGPIPLSLSSLRGLEALDLSDNNLSGGIPKFLMRFGALKYLNLSFNDLEGLIPSEGVFKNTSATFVEGNSKLCGGIPELHLSRCNSKKSSKTSLKLKITIMVVISGVTSVFSIFFIIWFRMKKEQKPMTTHVENSLLQLPYQSILRTTNGFCPQNLVGSGSFGSVYKGILEANGAVIAVKVFNLLNHRASRSFLVECEALKNIRHRNLVKFMENGSLEDWLHPSVGMNKPETMRNLNFFQRLNVAIDVAHALEYLHHRCETPIIHCDLKPSNVLLDGEMVGHISDFGLAKIHSVDKLNYSTNESSSLGLRGTIGYAPPEYGTGSELSTNGYVYSYGILLLEMLTGQRPTNERFKEGLSLNNFVKTALPDRVVEIIDPVLLQENVRGGTAAYITLNENNLGNDIHLQCLNSIFEIGLACSTESPSERMNMSNVITKLCSIRDKLLRPTRLRRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYT7</accession>
    <name>A0A0D2UYT7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G2779002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_011G2779002"/>
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        <property type="gene ID" value="B456_011G2779002"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB74184"/>
        <property type="gene ID" value="B456_011G2779002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74185">
        <property type="protein sequence ID" value="KJB74185"/>
        <property type="gene ID" value="B456_011G2779002"/>
    </dbReference>
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        <property type="component" value="Chromosome 11"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB74184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="20" mass="2333" checksum="D68BD3461B193EE3" modified="2015-04-29" version="1" fragment="single">CGFGLLMYEFEVHFYSSICS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A0D2V1N0_GOSRA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="3" type="ORF">B456_009G433500</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Malvales</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V1N0"/>
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        <property type="protein sequence ID" value="KJB62745"/>
        <property type="gene ID" value="B456_009G433500"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253912" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB62745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A0D2V4C2_GOSRA</name>
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    </protein>
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        <lineage>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_012G115400"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF7">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="7">
        <location>
            <begin position="134"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VBN4</accession>
    <name>A0A0D2VBN4_GOSRA</name>
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            <fullName evidence="11">MADS-box protein FBP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G069000</name>
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    <organism evidence="9 10">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_013G069000"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB79843"/>
        <property type="gene ID" value="B456_013G069000"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB79844"/>
        <property type="gene ID" value="B456_013G069000"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="K_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="K-box" evidence="8">
        <location>
            <begin position="85"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="119"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB79844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27738" checksum="0D59F7917CB95D2D" modified="2015-04-29" version="1">MGRGKIAIKRIENQTTRQVTFSKRRAGLLKKTHELSVLCDAQIGLIIFSSTGKMCQYCTQPYRMEQIIERYQKVTGTRIPEHDNREHLYNELAVLRKETRLLQLSMRRYTGEDMSSIPYEELDQLEQELERSVNKVRERKNELLQQQLDNLRRKERMLEEENNNMYRWIQEHRAAIEYQQQGGLEAKPVEHHQQVLDEFPFYGEPSSVLQLATIPQQFSYQLQLAQPNLQDSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQA1</accession>
    <name>A0A0D2VQA1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G223200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2VQA1"/>
    <dbReference type="Gramene" id="KJB73220">
        <property type="protein sequence ID" value="KJB73220"/>
        <property type="gene ID" value="B456_011G223200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047627">
        <property type="term" value="F:adenylylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="138" mass="15357" checksum="65A35F639D7C9714" modified="2015-04-29" version="1">MNSFYFACLYSCYFGFAGILCCELIMQRLERLLQLYLCRASPTHDEEAAKKAAAINSDSGAPTMYIIAKEIPSTIVYEDDKVLAFKDISPQAPVHVLVIPKFRDGLTQLGKVEQRHGEVLGQLLLLDAPLLKLSYPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQU5</accession>
    <name>A0A0D2VQU5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G234300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Intracellular vesicle trafficking and protein transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQU5"/>
    <dbReference type="SMR" id="A0A0D2VQU5"/>
    <dbReference type="STRING" id="29730.A0A0D2VQU5"/>
    <dbReference type="Gramene" id="KJB73470">
        <property type="protein sequence ID" value="KJB73470"/>
        <property type="gene ID" value="B456_011G234300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778195"/>
    <dbReference type="eggNOG" id="KOG0080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HECIKIL"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000456">
        <property type="entry name" value="Ras-related protein RABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB73470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="218" mass="24154" checksum="067EE3AD6FB71FF5" modified="2015-04-29" version="1">MLGSSSSSSKGGGNNNCDYSFKILLIGDSGVGKSSLLVTFISNFVHDLSPTIGVDFKIKMVTIGGKRLKLTIWDTAGQERFGTLTSSYYRGAHGIILVYDVTRRETFTNLSEVWAKEVELYSTNQECIKVLVGNKVDRDSERAVTQEEGMALAQQLKCSFLECSARTRANVHQCFKDLVLKILEVPTLLEKGSTAVKKQILQQKQVRKPPESNTCCFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VTI0</accession>
    <name>A0A0D2VTI0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alliinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_012G1724003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alliinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTI0"/>
    <dbReference type="STRING" id="29730.A0A0D2VTI0"/>
    <dbReference type="Gramene" id="KJB74515">
        <property type="protein sequence ID" value="KJB74515"/>
        <property type="gene ID" value="B456_012G1724003"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTGD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPADYDI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006948">
        <property type="entry name" value="Alliinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF15">
        <property type="entry name" value="TRYPTOPHAN AMINOTRANSFERASE-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04864">
        <property type="entry name" value="Alliinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alliinase C-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB74515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="260" mass="29109" checksum="D8EC399249D99975" modified="2015-04-29" version="1" fragment="single">SYPEETKFLRSELYKWAGDANCYDKDEPYIEVVTSPNNPDGSIRGTVVNREGGKAIHDLAYYWPQYAPITSKADHDAMLFTFSKATGHAGTRIGWAIVKDKVIAAKMVKFIEVSSIGVSREAQLRAAKVLGVIADDCRNPDVKGENFFEYGRRLMSERWGKLREVGMKSNGVFSLPKYPRDYCKFTGEYTDSNPAFAWLKSKEGLNCENLLRDESKIITRAGPSFGGDSTYTRVSMLSRDVEFELLLERLAAVKGTVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VV06</accession>
    <name>A0A0D2VV06_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G037100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
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                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Walford S.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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                <person name="Duke M.V."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Romanel E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
            <location evidence="2 14">Extracellular space</location>
            <location evidence="2 14">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W7F7"/>
    <dbReference type="SMR" id="A0A0D2W7F7"/>
    <dbReference type="Gramene" id="KJB82340">
        <property type="protein sequence ID" value="KJB82340"/>
        <property type="gene ID" value="B456_013G190600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783221"/>
    <dbReference type="OMA" id="PMEVNTD"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019612805" description="Germin-like protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="15">
        <location>
            <begin position="63"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB82340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="220" mass="23654" checksum="8AEDF27FBE76E881" modified="2015-04-29" version="1">MEALQIIVAIFILALASSLTFASDPSPLQDFCVAINDPKGSLFVNGKFCKDAKLAKADDFYFSGLHIRKNTSNTFGSTVTPVNVAQMPGLHTLGISMVRIDYAPNGGLNPPHTHPRASEILVVLEGTLHVGFVTSNPDNRLISKVLYPGDVFVFPVGLIHFQYNIGNTYAVAFAGLSSENPGVITIANAVFGSNPSINADILAKAFNLDRKMVKNLQSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M1R3</accession>
    <name>A0A0D2M1R3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G225400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M1R3"/>
    <dbReference type="STRING" id="29730.A0A0D2M1R3"/>
    <dbReference type="Gramene" id="KJB10802">
        <property type="protein sequence ID" value="KJB10802"/>
        <property type="gene ID" value="B456_001G225400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803860"/>
    <dbReference type="eggNOG" id="ENOG502QSCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="971472at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051942">
        <property type="entry name" value="DENN_domain_containing_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288:SF29">
        <property type="entry name" value="DENN (AEX-3) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15288">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="284" mass="32180" checksum="964A9BFF36474DE0" modified="2015-04-29" version="1">MTTRRCYCILSRLPFFELHFGVLNSIFDEERLERLTKSIGDMDLELSESYSNEANIDDVLTDQVALEDMQNTMTEPSEISSGDSKLGGNDDGNGLEHQMLESDFDSNKAVNHDTVVPVDLETESFKRGRESSGANPEDCDTDVDDFTTNKQAAERHLPNAVLPFLRYYQYESSESSCSFQGSPCDDRNLRSDVDDTETEEASISGQEDSSDHLDILEWAKANNHGSLQILCEYYRLPCPERGSKLRFHPLEHLHPLEYQRPDEKVLHIAGSTIDLRSCSFRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M2M5</accession>
    <name>A0A0D2M2M5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="19">1.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_001G243900</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="19"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M2M5"/>
    <dbReference type="STRING" id="29730.A0A0D2M2M5"/>
    <dbReference type="Gramene" id="KJB11177">
        <property type="protein sequence ID" value="KJB11177"/>
        <property type="gene ID" value="B456_001G243900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766797"/>
    <dbReference type="eggNOG" id="KOG2333">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000067">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000029">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 19" id="KW-0288">FMN</keyword>
    <keyword evidence="6 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 19" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="9 18 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="21">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="18">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="283"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB11177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="726" mass="80766" checksum="8437C6C4DCE397E7" modified="2015-04-29" version="1">MDDCPKDICAVTDSSTEGVPASQPPSDPDGTTQRSLEELVARAIAPVKREFLRPPPSSRTTQNNPASDANVKQPQANLVQEKKSKRQLKRERRQEQKSPLNLCPEIAKTGDVNACSYKDKCRFSHDIEAFMAQKPADLEGDCPFIKADAPCPYGLACRFAGTHKDNAPAATSNLLKKSSEVNGLNKDVQKLLWKNKMRFTKADVVVKSLGLAGPNWKVKKLVDKEEDEVGLDGSHAADKTDCKKVVDDSVDCSECPSTFPAAVNAEEACETDELRPLKKAKLVVDEKSSDEGEGATVLEKDNEKNSAETEPADNVLAEPDRSPKISNLKDATVLEKYNEKKSAETEPADDVHAEPDKSLKIHPREKMLIDFREKLYLAPLTTVGNLPFRRVCKTLGADVTCGEMAMCTNLLQGQASEWALLRRHSSEDLFGVQICGAYPDTIARTVELIEKECTVDFIDINMGCPIDIVVDKGAGSFLLTKPLRMKGIIQAASGTVDKPITVKVRTGYFGGKNRIDSLIADIGSWGATALTIHGRSRQQRYSKLADWDYIYQCAQKAPCTLQVLGNGDIFSYLDWNNRKTDCPELSTCMIARGALIKPWLFTEIKEQRHWDISSQERLNILKEYVRFGLEHWGSDKKGVETTRHFLLEWLSYACRYIPVGLLDVIPQRLNWRPPSYYGRDDLETLMASDSAADWIRISEMLLGKVPDGFTFAPKHKSNAYDRAENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MBD7</accession>
    <name>A0A0D2MBD7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G153200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MBD7"/>
    <dbReference type="STRING" id="29730.A0A0D2MBD7"/>
    <dbReference type="Gramene" id="KJB14981">
        <property type="protein sequence ID" value="KJB14981"/>
        <property type="gene ID" value="B456_002G153200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB14982">
        <property type="protein sequence ID" value="KJB14982"/>
        <property type="gene ID" value="B456_002G153200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785412"/>
    <dbReference type="eggNOG" id="KOG0719">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPTWREY"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042977">
        <property type="entry name" value="AtJ6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="34"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="287" mass="33084" checksum="3BF5917CB7A3DE6D" modified="2015-04-29" version="1">MGKRKKSRVSRDEDEEDEVVQEEEGNHSSSNEKSLYEILGVEKVASQQEIKKAYYKLALRLHPDKNPGDEEAKEKFQQLQKVISILGDEEKRAVYDQTGCVDDTDLAGDVVENLKSFFRTMYKKVTDADIEEFEANYRGSDSEKKDLIDLYRKFKGNMNKLFCSMLCSDPKLDSHRFKDMLDEAIAAGELKESKAYKKWAKKVSEMKPPTSPLRRKGKSNKQPESDLFAIISQRRNERKDRFDSMFSSLVSKYGGNAESEPTEEEFEAAKRKVESKKASNNSKRKRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MHJ7</accession>
    <name>A0A0D2MHJ7_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">B456_003G005600</name>
        <name evidence="3" type="ORF">Gorai_023800</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0581625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MHJ7"/>
    <dbReference type="Gramene" id="KJB17562">
        <property type="protein sequence ID" value="KJB17562"/>
        <property type="gene ID" value="B456_003G005600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787429"/>
    <dbReference type="OMA" id="RIKLCHN"/>
    <dbReference type="OrthoDB" id="997029at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038796">
        <property type="entry name" value="At1g76070-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34779">
        <property type="entry name" value="OS09G0542900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34779:SF10">
        <property type="entry name" value="SYRINGOLIDE-INDUCED PROTEIN 14-1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0581625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="160" mass="18290" checksum="5062BB9417E5A787" modified="2015-04-29" version="1">MVKPVKHRSKIILTFRLSPPVITGGKRISGHTVPLIPRNASFELREPVSPKVSCMGQIIKKKKIRSLKKLKQRSSSSSRPSQAFAEKIKSKVLKRIKLCHNNHHTLIDDYEVSAVEEDDDDDERSAPSLLQMRRFNNVRSTLSDFDWTTSEEKGVKRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MKD6</accession>
    <name>A0A0D2MKD6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_003G070100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MKD6"/>
    <dbReference type="Gramene" id="KJB18812">
        <property type="protein sequence ID" value="KJB18812"/>
        <property type="gene ID" value="B456_003G070100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788109"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPRVNMY"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000632">
        <property type="entry name" value="RING-H2 finger protein ATL73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044602">
        <property type="entry name" value="ATL10/ATL72-79-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46905:SF7">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="128"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB18812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="215" mass="23407" checksum="7FD4E795F2C80A5A" modified="2015-04-29" version="1">MSISIPTQVLPGLLGEFHCRRLLLTPTTASPPSPEIHHNSSDLYTRNNSFDANIVMVLSVLLCALICSLGLNSIIRCALRCSSLVASESGATTSSRLANKGVKRKALKTFPTVNYSADLKLPGLDSECIICLSDFTAGDRVRLLPKCNHGFHVRCIDKWLSAHSSCPKCRHCLVDTCQKIVGCTQASSSEPPPVQETILSIITPVDREGFIHSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MWK3</accession>
    <name>A0A0D2MWK3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CCR4-NOT transcription complex subunit 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G107500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MWK3"/>
    <dbReference type="STRING" id="29730.A0A0D2MWK3"/>
    <dbReference type="Gramene" id="KJB23622">
        <property type="protein sequence ID" value="KJB23622"/>
        <property type="gene ID" value="B456_004G107500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791028"/>
    <dbReference type="eggNOG" id="KOG2471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25157at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039740">
        <property type="entry name" value="CNOT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12979:SF5">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="778"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="588"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB23622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="93637" checksum="4D567C3F5AA03093" modified="2015-04-29" version="1">MDLRDSSPSSTPNRDGNAGDDDGVLSATSALAKDAALYFQSRKFAECVDVLNQLNSKKENDPKVLHNIAIAEFFRDGCSDPKKLLEVLNNVKKRSEELALLAFGEQVESGSNIGNNITSGSKGCGTTTSLPASNCASIIYTDEFDTSVASLNIAVIWFHLHEYSKALSVLEHVYQNIEPIDETTALHICLLLLDVLLACRDVSKSADVLNYLEKAFGVGNVSQGENGNTAPQQSLNVVGKSSSDPNSSLISDVSCSDLVASVNASESPLSRTLSEDPLDEMFSTLDIGGQNFARHTGLTSANDLPRITVDRSISGVDLKLKLQLYKVRLLLLTRNVKLAKREVKHAMNIARGRDSSMALFLKAQLEYARGNHRKAIKLLMASSNRTDAAMSSMFNNNLGCIYYQLGKYHTSAVFFSKALSNCSSLQKEKPLKLLTFSQDKSLLLTYNCGLQYLACGKPLLAAHCFQKASLVFYRRPLMWLRLAECCLMAVEKGIVKGSWAPSDRSEVRVSVIGKGRWRRLLIENGISRNRHVDSVEREVWALGGDGQPKLSLPLARQCLYNALHLLNCSELCNSKSIVCSDSSLEENESSDGASSKNSNYKNLPCNDSKASTMPAALINLNGDLKEPKGGTNQEGIQNSISYYEDICRRENQMIKQALLANLAYVELELENPLKALSAAQALLELPDCSRIYVFLGHVYVAEALCLLNKPKEAAEHLSIYLSGESNIKLPFGLEDCEQWRVKKHIDCEEANVGAAAAKNSSPEGLEDFMFLKPEEARGTLYANLAAVSAIQGDLERAHHFVTQALSLVPNSSEATMTAIYVDLILGKSQEAVYKLKHCSHVRFLPSNQQFNKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N4M9</accession>
    <name>A0A0D2N4M9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G022600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N4M9"/>
    <dbReference type="STRING" id="29730.A0A0D2N4M9"/>
    <dbReference type="Gramene" id="KJB07423">
        <property type="protein sequence ID" value="KJB07423"/>
        <property type="gene ID" value="B456_001G022600"/>
    </dbReference>
    <dbReference type="OMA" id="CYTAPYS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021899">
        <property type="entry name" value="DUF3511"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33193">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF3511)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33193:SF62">
        <property type="entry name" value="FAMILY ABC TRANSPORTER, PUTATIVE (DUF3511)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12023">
        <property type="entry name" value="DUF3511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB07423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="12904" checksum="368874315CE6CC2F" modified="2015-04-29" version="1">MADYKSSRSYGNGMMMQLETYHEPPPPASNYDLWCYTAPYSQSHMADNYYPNNGNCSKPWNFGELEFQRKKRVATYKMYSAESKVKGSLKRSFRWLKHKYIQVVYGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8F7</accession>
    <name>A0A0D2N8F7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G064500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8F7"/>
    <dbReference type="STRING" id="29730.A0A0D2N8F7"/>
    <dbReference type="Gramene" id="KJB28667">
        <property type="protein sequence ID" value="KJB28667"/>
        <property type="gene ID" value="B456_005G064500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXTQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTYAKHR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010427">
        <property type="term" value="F:abscisic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038023">
        <property type="term" value="F:signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000007">
        <property type="entry name" value="Major pollen allergen Bet v 1-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024949">
        <property type="entry name" value="Bet_v_I_allergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050279">
        <property type="entry name" value="Plant_def-hormone_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213">
        <property type="entry name" value="OS08G0374000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31213:SF55">
        <property type="entry name" value="STRESS-INDUCED PROTEIN SAM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00634">
        <property type="entry name" value="BETALLERGEN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="4">
        <location>
            <begin position="2"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB28667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="175" mass="19163" checksum="8CD56058DDC61DF3" modified="2015-04-29" version="1">MGVFAKEAEVSTPLPPAKAFKAFVVDLDTLMPKVAPQAINSVELLQRDGGPGTIKKITFAEDKDNLLYTYVVIESDFFNNVVEKISYETKFVAVADGGTSIKVTTTFYTIGDIQISPDLMLQIKEASEKRALVLKAIENCAGQSVEVGQHAALFSQKQLEPVKLLQSKLLFCFVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NAB6</accession>
    <name>A0A0D2NAB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G100800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NAB6"/>
    <dbReference type="STRING" id="29730.A0A0D2NAB6"/>
    <dbReference type="Gramene" id="KJB29442">
        <property type="protein sequence ID" value="KJB29442"/>
        <property type="gene ID" value="B456_005G100800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YIPSIGH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB29442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="15098" checksum="56757E9BB08DE54B" modified="2015-04-29" version="1">MESVQLEHENVTEFVLVTLRDRVEEGRRFSNEEKDPMTSKELNEEPKGDLSVNFSTITPKKPNSALRKVAKVRLTSGFEITAYIPGIGHNSQEHSVVLVRGGRVEDLPSVRYHIVRGTLDAVGVKDRQQGRSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NAP5</accession>
    <name>A0A0D2NAP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_005G109600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NAP5"/>
    <dbReference type="STRING" id="29730.A0A0D2NAP5"/>
    <dbReference type="Gramene" id="KJB29602">
        <property type="protein sequence ID" value="KJB29602"/>
        <property type="gene ID" value="B456_005G109600"/>
    </dbReference>
    <dbReference type="OMA" id="ANQPIMT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF38">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="53"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB29602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="173" mass="20156" checksum="6B66D786DE42EA11" modified="2015-04-29" version="1">MSPVVSEILRSGFIINSSLRRRTHLVQSFSVVFLYCGNSNSNSSGSTQHQLMDQRKRKRMESNRESARRSRMRKQKHLDDLVGQITELKKDNNQILTSINFTTHRYLNIEAENSVLRAQMTELSQRLDSLNDILQYLNREGIEYTPDCFTNPFNVPYLNQQPPIMASAHIFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NAW9</accession>
    <name>A0A0D2NAW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G115700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the major facilitator superfamily. Phosphate:H(+) symporter (TC 2.A.1.9) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NAW9"/>
    <dbReference type="STRING" id="29730.A0A0D2NAW9"/>
    <dbReference type="Gramene" id="KJB29717">
        <property type="protein sequence ID" value="KJB29717"/>
        <property type="gene ID" value="B456_005G115700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793869"/>
    <dbReference type="eggNOG" id="KOG0252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKVARFQ"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000175">
        <property type="entry name" value="Inorganic phosphate transporter 1-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="478"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="21"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB29717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="524" mass="58195" checksum="5A6FA344B6C7DF11" modified="2015-04-29" version="1">MALKVLSALDAAKIQLYHFKAIIIAGMGLFTDAYDLFCIPPIMKLIGRIYYLDHHNSDKCSVMPKETQYKTTPTAVVSTLVSIALLGTAVGQLVFGRLGDRAGRRRVYGLSLGMMVLSSLACGFSICKTRNCVLVSLGFFRFLLGVGIGGDYPLSATIMSEFANKKTRGAFIAAVFSMQGLGILASSIVTMVVCRIFAVSSNEAKSETPDEADLAWRLILMMGAVPAALTYYWRMMMPETARYTALVEQNVVQAAIDMKKVLDVPMSEIAEDSPIRLKPPALPHPSYPLLSKRFLRRHGVDLFCCAATWFLVDVVFYSSNLLQSQIYHRFIKDNNDVNGYKLAFKVARFQAILAISSTIPGYWVTVYFIDRIGRVKIQMLGFLFMALVYFAIGIPYKYYWSENISVGFMALYSLSFFFSNFGPNTTTFIVPAELFPARFRSTCHGIAGAVGKVGAIIGTIGFFWASRNEKDSGKPNPVRMTVALVILGVVCLVGLLLTYFLTRETMGRSLEDNEIYEDELIYNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJ81</accession>
    <name>A0A0D2NJ81_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">IBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G074100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJ81"/>
    <dbReference type="STRING" id="29730.A0A0D2NJ81"/>
    <dbReference type="Gramene" id="KJB13367">
        <property type="protein sequence ID" value="KJB13367"/>
        <property type="gene ID" value="B456_002G074100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB13368">
        <property type="protein sequence ID" value="KJB13368"/>
        <property type="gene ID" value="B456_002G074100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB13369">
        <property type="protein sequence ID" value="KJB13369"/>
        <property type="gene ID" value="B456_002G074100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0166">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFNININ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="42671" checksum="4B50AC5917631DA6" modified="2015-04-29" version="1">MKWLFKFDKDKWQKRQRQMQKNLRSMESIRKINRELILFFKRNHEFFHVERCIEDAAGDPIAIQKMFDSIPVMASDLMSGNESFQFAATARLSFLLSTENPPIDVVIQSGVVPHFVRFLNEQYGLQHKLYSVRALYAIGKGSLEQAVVVIKHGAIPMFIRLLCCSEECYQLKELVAAALGSLANQSPDFRDYVLQFGTLTPLLSLLDNHLEPPMLHEKIALLRTCSNTLAIFCQGNPAPSFNQIRSALPILRRLIHLNPPVGVIGEVCEDACLCLSYLSNGSAEQIQALIDADVCARLVMLLGLSDGKIVEHVLRTVGNIFKGVDSQIQILINNGVFFRLNAILMHGSNSSVLRKTCSAISTLTARDRNQIQVGIYYGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKD7</accession>
    <name>A0A0D2NKD7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G095400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKD7"/>
    <dbReference type="STRING" id="29730.A0A0D2NKD7"/>
    <dbReference type="Gramene" id="KJB13808">
        <property type="protein sequence ID" value="KJB13808"/>
        <property type="gene ID" value="B456_002G095400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31208:SF11">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31208">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="306" mass="34078" checksum="E19503A0FF34BEAE" modified="2015-04-29" version="1">MGFALLGSLGSFVSVRDSHHWNVRFQSFTLKERFVVGFNLAKNFRAYKKFGRVSLCKSEFVDFEERTSPNEVRKEIEQCYELIHRLGRGVVYLGSSRMGPGHPHYAQTLELAREIANLLDCTTWTGAGPGLMDAAIKGAQEAGKAVGGFKIGKEAGEWTTSKFHPYLPSETYLTCRFFSARKHGLVDAAVRSSSSDKTAVVALPGGVGTLDEMFEILALIQLERIGSELPVPFIVMNYDSFYAKLLDFLDDCEDWGTVSKGEVSSLWKICNTNSDALAYLAEFYDLPFLDEQKHGTEARSARKQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NSM9</accession>
    <name>A0A0D2NSM9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G251500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. AP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NSM9"/>
    <dbReference type="STRING" id="29730.A0A0D2NSM9"/>
    <dbReference type="Gramene" id="KJB16843">
        <property type="protein sequence ID" value="KJB16843"/>
        <property type="gene ID" value="B456_002G251500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786446"/>
    <dbReference type="eggNOG" id="ENOG502QSBE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWAWQLQ"/>
    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000002">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000004">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF226">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="149"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="241"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB16843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="53242" checksum="1FC319C968BDBF8F" modified="2015-04-29" version="1">MVLDLNLTVISDGDDNSMAGGFSGYNNNQMDSSGGSFGSSVVNADTATTAGDDDSSSNAAATDTFGYSFDILKASREEEQDKYNNRTTIPLFPVDVEGNGWKSTGWLDLAGSGEVAAEQRVVPHQHQQQVQLRQQVKKSRRGPRSRSSQYRGVTFYRRTGRWESHIWDCGKQVYLGGFDTAHAAARAYDRAAIKFRGTDADINFNVSDYDDDIKQMSNFTKEEFVHILRRQSTGFSRGSSKYRGVTLHKCGRWEARMGQLLGKKYIYLGLFDSEIEAARAYDKAAIKCNGREAVTNFEPSTYEGELISESENGDQNRVLDLNLGIAPPCTSNLQKENENSSNFPFQRGYDGLPVASGARFENSAPATMRVQPSLGQATAFKHVPNWNVANPSFFPVYRERAIEKRIEVDSPPWQIQGPYGGTKEMPLFPSAASSGFSSSIITSPSAAAGQLRVPNATFLQHHFPPVIMNSNTPHFYCRTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P365</accession>
    <name>A0A0D2P365_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G176300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P365"/>
    <dbReference type="STRING" id="29730.A0A0D2P365"/>
    <dbReference type="Gramene" id="KJB20983">
        <property type="protein sequence ID" value="KJB20983"/>
        <property type="gene ID" value="B456_003G176300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2350">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMSHNPR"/>
    <dbReference type="OrthoDB" id="166746at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21553">
        <property type="entry name" value="VEFS-box_EMF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21749">
        <property type="entry name" value="ZnB-Zn_EMF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019135">
        <property type="entry name" value="Polycomb_protein_VEFS-Box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057540">
        <property type="entry name" value="Znf_SUZ12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF0">
        <property type="entry name" value="POLYCOMB PROTEIN SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09733">
        <property type="entry name" value="VEFS-Box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23320">
        <property type="entry name" value="Zn_SUZ12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Polycomb protein SUZ12-like zinc finger" evidence="9">
        <location>
            <begin position="65"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Polycomb protein VEFS-Box" evidence="8">
        <location>
            <begin position="286"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB20983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="426" mass="48763" checksum="62D06F03109D059C" modified="2015-04-29" version="1">MCRQNSCLHLSAEETDTTVENLLVYCKPVELYNILRCRALHNPSYLRRCLKYKIQARRKRRLRAGIVIFNYKDYGNMLQKTEVTEDFSCPFCLMQCASFKGLRYHLCSSHDLFNFDFWVTEEYQAVNVSVKIDSLVSETLANGVDPRVETFCFCSKSRRRRSTSPLQCVKNVSVQFLEMDSPKIVSENRQNGSLENDGERASKSIPLEKDLQNGYNGLENYGSDYASATECLARVANSCDGPGVSIAMAHSPLDPDCIKTVSGTDIAAPPAKTRKIAVDRSEPRNRLLLLRRQFFHSHRVQPMEMDQVMSDRDSEDEVDDDIADLEDRRMLDDFVDVSKDEKQLMHLWNSFVRKQRVLADGHVSWACEAFSKLHGLDLVKSPALFWCWRLFMIKLWNHGLLDAGAMNNCSMILQRCQNEGSDAMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P7A8</accession>
    <name>A0A0D2P7A8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G112900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Tetramer of 2 alpha and 2 beta subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="8"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P7A8"/>
    <dbReference type="STRING" id="29730.A0A0D2P7A8"/>
    <dbReference type="Gramene" id="KJB41627">
        <property type="protein sequence ID" value="KJB41627"/>
        <property type="gene ID" value="B456_007G112900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802846"/>
    <dbReference type="eggNOG" id="KOG0225">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPYRRMW"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="10">
        <location>
            <begin position="93"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB41627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="432" mass="47434" checksum="B7B8592AC2CC3EB8" modified="2015-04-29" version="1">MNSASCAAKISTQPFSLNPTSPTSHDRPLVSPKPTSLFLGSTRKLRLSSSSKLNLHRRSGTVVAVSDVVKQKKSKSTHSLLITKEEGLELYEDMILGRAFEDMCAQMYYRGKMFGFVHLYNGQEAVSTGFIKLLKQQDSVVSTYRDHVHALSKGVPARAVMSELFGKTTGCCRGQGGSMHMFSREHNLLGGFAFIGEGIPVATGAAFTSKYKREVLKEADCDHVTLAFFGDGTCNNGQFFECLNMAALWKLPIVFVVENNLWAIGMSHLRATSDPQIYKKGPAFGMPGIHVDGMDVLKVREVAKDAIGRARRGEGPTLVECETYRFRGHSLADPDELRDPAEKAHYAARDPITALKKYLIENSLASEADLKAIDKKIDEVVEDAVEFADESPVPSQSQLLENVFADPKGFGIGPDGRYRCEDPKFTEGTAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PAD6</accession>
    <name>A0A0D2PAD6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phytochrome</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_007G166300</name>
        <name evidence="16" type="ORF">Gorai_018890</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Contains one covalently linked phytochromobilin chromophore.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phytochrome family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PAD6"/>
    <dbReference type="STRING" id="29730.A0A0D2PAD6"/>
    <dbReference type="Gramene" id="KJB42732">
        <property type="protein sequence ID" value="KJB42732"/>
        <property type="gene ID" value="B456_007G166300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB42734">
        <property type="protein sequence ID" value="KJB42734"/>
        <property type="gene ID" value="B456_007G166300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803411"/>
    <dbReference type="eggNOG" id="ENOG502QT1B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017006">
        <property type="term" value="P:protein-tetrapyrrole linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009585">
        <property type="term" value="P:red, far-red light phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16932">
        <property type="entry name" value="HATPase_Phy-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000039">
        <property type="entry name" value="Phytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000001">
        <property type="entry name" value="Phytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000064">
        <property type="entry name" value="Phytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044767">
        <property type="entry name" value="Phy_HATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013516">
        <property type="entry name" value="Phyto_chromo_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012129">
        <property type="entry name" value="Phytochrome_A-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47876">
        <property type="entry name" value="OS08G0260000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47876:SF3">
        <property type="entry name" value="PHYTOCHROME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000084">
        <property type="entry name" value="Phytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00245">
        <property type="entry name" value="PHYTOCHROME_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0157">Chromophore</keyword>
    <keyword evidence="3 9" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="8 9" id="KW-0675">Receptor</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="12">
        <location>
            <begin position="219"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="613"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="755"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="897"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="10">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>phytochromobilin</name>
            <dbReference type="ChEBI" id="CHEBI:189064"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000084-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0590174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125395" checksum="48A9602B23C92565" modified="2015-04-29" version="1">MSSMSTNKSNCSRSSSARSKQNARVIAQTTIDAKLHVDFEESKRLFDYSTSIDFNISSSTSNVPSSTVSAYLQKMQRGSLIQPFGCLIAVDEQNFTVLAYSENAPEMLDLAPHAVPNIEQQEALTYGSDVRTLFSSPGATALQKAANFGEVNLLNPILVHCKTSGKPFYAILHRIEAALVIDLEPVNPAEVPVTAAGALKSYKLAAKAISRLQSLPSGNISLLCDVLVKEVSDLTGYDRIMVYKFHEDEHGEVIAESRRPDLEPYLGLHYPATDIPQASRFLFMKNKIRMICDCSAQPVKVIQDKGLAQPLSLCGSTLRSPHGCHAQYMASMGSIASLVMSVTINENDDEMDSEQDKGRKLWGLVVCHHTSPRFVPFPLRYACEFLIQVFGVQINKEVDLAAQMREKHILQTQTVLCDMLLRDSPVGIVTKSPNVMDLVKCDGAALYYRQKFWLLGVTPTKAQIRDIAEWLLEYHSSSTGLSTDSLMEAGYPGASVLGEAVCGMAAVKITSKDFLFWFRSHTAKEIKWGGAKHDPGGKDDGRKMHPRSSFKAFLEVVKWRSLPWEDIEMDAIHSLQLILKGSLQDEVADDSKMIVNVPSIDDRIQRVDELRIVTNEMVRLIETAAVPIFAVDSSGNINGWNSKAAELTDLTIEQAIGMPLFDLVEDDSVDVVKNMLSLALEGIEERSIEIKLRTFGCQENNGPIILVVNACCSRDLKENVVGICFVGQDLTSQKMAMNKYTRVQGDYVGIMRNPSALIPPIFMIDEVGRCLEWNDAMQKLTGMKREEAIDRMLLGEVFTVDKFGCRVKDHDTFTKLRILFNGITAGEDADKLLFGFFDQEGKFVEVLLSASRRTDANGRITGILCFLHVASPELQYALQVQKISEQAAASSLNKLAYIRQELRKPLKGIVLMQGLMGDSDLSSNQRQLLRTSVMCREQMAKIVDDTDIESIEECYMEMDSGEFNLGEALEAVLKQVMLMSQERQVQVIQDLPPEVSSMYLYGDNLRLQQVLSDFLTNALLFTPVFEESSVSFRVIPRKERIGTKIQIVYLEFRITHPAPGIPEDLIREMFHQRQGVSREGLGLYISQKLVKIMNGTVQYLREAERSSFIIFLEFPLARLLGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PKI6</accession>
    <name>A0A0D2PKI6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G374700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PKI6"/>
    <dbReference type="STRING" id="29730.A0A0D2PKI6"/>
    <dbReference type="Gramene" id="KJB46567">
        <property type="protein sequence ID" value="KJB46567"/>
        <property type="gene ID" value="B456_007G374700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761815"/>
    <dbReference type="eggNOG" id="KOG1475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYLEFEN"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB46567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="406" mass="44828" checksum="363F21701B979F38" modified="2015-04-29" version="1">MAAAAARPLVSVQTIESDMATDATPTVPLADVMKASIRPDIVTFVHDNISKNSRQPYAVSKRAGHQTSAESWGTGRAVSRIPRVPGGGTHRAGQGAFGNMCRGGRMFAPTKIWRRWHRKINVNQKRYAVASAIAASAVPSLVMARGHRIESVPEMPLVISDAVESVEKTSAAIKVLKQVGAYPDVEKAKDSQGIRPGKGKMRNRRYISRKGPLIVYGTEGAKLVKAFRNIPGVEVANVERLNLLKLAPGGHLGRFIIWTKSAYEKLDSIYGSFEKPCEKKKGYILPRSKMVNADLGRIINSDEVQSVVKPIKKEIKRAPLKKNPLKNLNAMLKLNPYAKTARRMSLLAEAQRVKAKKEKLDKKRKPISKEEATAIKSAGKAWYQTMISDSDYTEFENFSKWLGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRV5</accession>
    <name>A0A0D2PRV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_001G008900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(S)-malate + NADP(+) = pyruvate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18253"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.40"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="1.1.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRV5"/>
    <dbReference type="STRING" id="29730.A0A0D2PRV5"/>
    <dbReference type="Gramene" id="KJB06731">
        <property type="protein sequence ID" value="KJB06731"/>
        <property type="gene ID" value="B456_001G008900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789558"/>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQANNCY"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004473">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000002">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000067">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF89">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="13">
        <location>
            <begin position="116"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="12">
        <location>
            <begin position="307"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00051384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB06731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="591" mass="65225" checksum="59C2D18D31A8EC30" modified="2015-04-29" version="1">MESTLKEMRGGESVLDLSPKATVGGGVEDVYGEDFATEEQLVTPWTYSVASGYSLLRDPHHNKGLAFTEKERDSHYLLGLLPPAVVTQQLQEKKLMDNLRKYEVPLQKYMAMMELQERNERLFYKLLIDNVEELLPIVYTPTVGEACQKYGSIFRRPQGLYISLKEKGKVLDVLKNWPERNIQVIVVTDGERILGLGDLGCQGMGIPVGKLSLYTALGGVRPSAGLPVTIDVGTNNEQLLKDEFYIGLRQRRATAQEYADLLHEFMSAVKQNYGEKVLIQFEDFANHNAFTLLAKYGTTHLVFNDDIQGTASVVLAGVVAALKLIGGTLADHKFLFLGAGEAGTGIAELIALEMSKQTKIPVEETRKKIWLVDSKGLIVNSRKESLQHFKKPWAHDHEPVKDLLGAVKAIKPTVLIGSSGVGRTFTKEIIETVTSFNEKPLIMALSNPTSQSECTAEEAYTWSQGRAIFASGSPFDPFEYNGKVFVPGQANNAYIFPGFGLGLVISGAIRVHDDMLLAASEALAKQVSDENYNKGLIYPPFSNIRKISANIAANVAAKAYELGVATRLPRPANLVKYAESCMYSPVYRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTL9</accession>
    <name>A0A0D2PTL9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-related protein 123</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G020600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTL9"/>
    <dbReference type="STRING" id="29730.A0A0D2PTL9"/>
    <dbReference type="Gramene" id="KJB07406">
        <property type="protein sequence ID" value="KJB07406"/>
        <property type="gene ID" value="B456_001G020600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801260"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMINATW"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000302">
        <property type="entry name" value="Transcription factor TT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999:SF86">
        <property type="entry name" value="MYB-RELATED PROTEIN MYB4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB8-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="271" mass="30481" checksum="9667D8647B557FB8" modified="2015-04-29" version="1">MGRSPCCSKEGLNKGAWTALEDKILTSYIHVHGEGKWRNLPKRAGLKRCGKSCRLRWLNYLRPDIKRGNISHDEEELIIRLHNLLGNRWSLIAGRLPGRTDNEIKNYWNTTLGKRAKAQASIEAKTIPTESRLNKPSKSSTKIEVIRTKAIRCSSKVMVPLQPPATHQHGQHHYTNNNEEMGGGISTIEAHNGIQMLESLYSDGGSNLLSFEINELLKSHDGGEFEENPMQQHFPLGEAMLKDWSTCPCLDDNGATDLESLAFLLDTDEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PU10</accession>
    <name>A0A0D2PU10_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Flavin-containing monooxygenase</fullName>
            <ecNumber evidence="11">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G028900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>indole-3-pyruvate + NADPH + O2 + H(+) = (indol-3-yl)acetate + CO2 + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:30854"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.13.168"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Plant hormone metabolism; auxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PU10"/>
    <dbReference type="STRING" id="29730.A0A0D2PU10"/>
    <dbReference type="Gramene" id="KJB07541">
        <property type="protein sequence ID" value="KJB07541"/>
        <property type="gene ID" value="B456_001G028900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764574"/>
    <dbReference type="eggNOG" id="KOG1399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVQGPIV"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103075">
        <property type="term" value="F:indole-3-pyruvate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009851">
        <property type="term" value="P:auxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000100">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF38">
        <property type="entry name" value="INDOLE-3-PYRUVATE MONOOXYGENASE YUCCA6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00469">
        <property type="entry name" value="PNDRDTASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0073">Auxin biosynthesis</keyword>
    <keyword evidence="5 11" id="KW-0274">FAD</keyword>
    <keyword evidence="4 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB07541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="434" mass="48523" checksum="883AD92EC83421B6" modified="2015-04-29" version="1">MDYLSEIEGKQAHDPMFLEKMKESSSSSSSSCLCVPGPVIVGAGPSGLATAACLKEKGVPSVILERSNCIASLWQLKTYDRLRLHLPKQFCELPLMGFPTGFPTYPSKQQFVDYLEAYARKFDIKPRFNETVSQAEYDPTLGFWRVTSVGVKGKEMEYVCRWLVVATGENAEAMMPEMEGMGEFSGDIRHTSLYKSGEEFRGKRVLVVGCGNSGMEVCLDLCNHNARPSLVVRDTVHVLPQEMLGTSTFGLSMWLLRWFPLRLVDRFLLIVSWLMLGDTARFGLARPHLGPLQLKNLSGKTPVLDVGTLAKIKSGDIKVRPSIKSLKRHAVEFVNGTTENFDAIILATGYKSNVPSWLKEKVMFSEKDGYPRRPFPNGWKGEYGLYAVGFTKRGLLGTSMDAIRIAEDIQRCWKEEAKHRLAFTNSLLHQSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PX38</accession>
    <name>A0A0D2PX38_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial import receptor subunit TOM40-1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G213300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Directly involved in the pore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PX38"/>
    <dbReference type="STRING" id="29730.A0A0D2PX38"/>
    <dbReference type="Gramene" id="KJB31898">
        <property type="protein sequence ID" value="KJB31898"/>
        <property type="gene ID" value="B456_005G213300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794994"/>
    <dbReference type="eggNOG" id="KOG3296">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISGRMNH"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000010">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="34540" checksum="89C15EAA9A53508C" modified="2015-04-29" version="1">MAGLVPPGTSSDASKPAHSKADEKTDYMNLPCPIPYEELHREALMSLKPETFEGLRFDFTKGLNQKFSLSHSVFMGPTEIPSQSAETIKIPTAHYEFGANFIDPNLMLIGRVLTDGRLNARLKWDLSDNFTVKANAQLSNEPHMSHGMFNFDYKGKDFRSQFQMGNGALFGASYIQSITQHLSLGGEVFWAGQHRKSGIGYAARYETDKMVATGQVANTGIVALSYVQKVSDKVSLATDLMYNYMSRDVTASVGYDYILRQCRLRGKIDSNGCTTSYLEERLNMGLNFILSAEIDHRKKDYKFGFGLTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PXT4</accession>
    <name>A0A0D2PXT4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G224300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PXT4"/>
    <dbReference type="STRING" id="29730.A0A0D2PXT4"/>
    <dbReference type="Gramene" id="KJB32108">
        <property type="protein sequence ID" value="KJB32108"/>
        <property type="gene ID" value="B456_005G224300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1PH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRQPECL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18917">
        <property type="entry name" value="bHLH_AtSAC51_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037546">
        <property type="entry name" value="SAC51-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36066">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH145"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36066:SF8">
        <property type="entry name" value="TRANSCRIPTION FACTOR SAC51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23173">
        <property type="entry name" value="bHLH_SAC51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="5">
        <location>
            <begin position="293"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="38577" checksum="B161BC7FDAF5F36D" modified="2015-04-29" version="1">MSASLEPRQPECLPACINPSSHMLSASVSKLGSLVPGMNYGTHLLPAKIAMPGSADISVLKTEQKYQPHGLLQQLYPSFPTSLPCRGSFLNEQQFKIANGHTGRAAANFVSGSLQKGLIIFDHSGSQTRLICGSFRSPHQHAATAITELASSLDIHEGVQAVKTNSLIPTPPALQKEYDENHLGVEGSEMREDTEELNALLYSDEEEEDFGVGDDDCDDDEVMSTAHSPIGIKRSYQNQGHDYDVIEQVASSDGPNKRQKLLNGGHKQLIMVDGACSVKLEGSHEYDSNAESSYRGEILHTEQSMKDKIHLTLKILESIIPGTKGKDPLLVLDESVDYLKSLKLEAETLGVNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5N4</accession>
    <name>A0A0D2Q5N4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G132800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q5N4"/>
    <dbReference type="STRING" id="29730.A0A0D2Q5N4"/>
    <dbReference type="Gramene" id="KJB14594">
        <property type="protein sequence ID" value="KJB14594"/>
        <property type="gene ID" value="B456_002G132800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ84">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECFIPPD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006873">
        <property type="entry name" value="DUF620"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31300">
        <property type="entry name" value="LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31300:SF31">
        <property type="entry name" value="PUTATIVE (DUF620)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04788">
        <property type="entry name" value="DUF620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB14594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="442" mass="48801" checksum="AE858E16ABC95D8D" modified="2015-04-29" version="1">MERKQESRSRAKSPARTASPMSNLLRRRRKNYSHHPEPFFFRSGGLRPAEALSPLKEGPDPDGTDAENSRMEGRWAQWMKGQLARGGPSVSTSTCKRSDLRLLLGVLGAPLAPVHVSALDSFSHLTIKDTPIESSSAQYILQQYTAASGGQKLQNSIHNAYAMGRVRMIASEFQTANKVTKNRNSTKVAESGGFVLWQMNPDMWYVELALGASKVHAGCNGKLVWRHTPWLGAHATRGPVRPLRRALQGLDPRTTASMFTNARCSGEKQINGEDCFILKLCADPATLKARSEGPAEIVRHVLFGYFSQKTGLLVHLEDSHLTRIQNNGGDAVYWETTIDSSLEDYRLVEGIMIAHSGRSVVTLFRFGDTAMSHTRTRMEEAWAIEEVAFNVPGLSAECFIPPDEIRLASMDEACEFSQGPTLKTSLATAPYRPKVGKLDKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q758</accession>
    <name>A0A0D2Q758_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G104700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q758"/>
    <dbReference type="STRING" id="29730.A0A0D2Q758"/>
    <dbReference type="Gramene" id="KJB35213">
        <property type="protein sequence ID" value="KJB35213"/>
        <property type="gene ID" value="B456_006G104700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799141"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDHRYKS"/>
    <dbReference type="OrthoDB" id="8113227at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010447">
        <property type="term" value="P:response to acidic pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010044">
        <property type="term" value="P:response to aluminum ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000145">
        <property type="entry name" value="Zinc finger protein 574"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044300">
        <property type="entry name" value="STOP1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058196">
        <property type="entry name" value="zf-C2H2_STOP1/2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059161">
        <property type="entry name" value="Znf-C2H2_STOP1/2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46352">
        <property type="entry name" value="PROTEIN SENSITIVE TO PROTON RHIZOTOXICITY 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46352:SF8">
        <property type="entry name" value="PROTEIN SENSITIVE TO PROTON RHIZOTOXICITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23115">
        <property type="entry name" value="zf-C2H2_STOP2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23118">
        <property type="entry name" value="zf-C2H2_STOP2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB35213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="376" mass="41767" checksum="6E2865EB661C29D8" modified="2015-04-29" version="1">MISDTIPSSFPNASQALPMYPMTDHQDHINVPYSCLEAPGSGSDLAPSTSLLYNLSILEDKVNQLQSLVSNLISPDQIHPESTGSLAIASMDSLVQEIIGAASSMGLVSQHMSLGTTSGNNNGISKQPNFTDDFAGGNLVQERGQGSYPSVDQTFSWYDRNSIHNNRSLQVGNADKLKERKELGEMVQRSEISEGSQGDAGTNYDIVELDAEDLLAKYTHYCQVCGKGFKRDANLRMHMRAHGDEYKTNAALVNPMKSHEGSSNGMGNCSTKFPKRYSCPYEGCRWNQKHANFQPLKSMICVKNHYKRSHCPKMYVCKRCNRKQFSLLSDLRTHEKHCGDLRWQCSCGNTFSRKDKLMGHVALFVGHRPVVAHSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q796</accession>
    <name>A0A0D2Q796_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Photosystem II 10 kDa polypeptide, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G032900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Associated with the oxygen-evolving complex of photosystem II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the psbR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q796"/>
    <dbReference type="STRING" id="29730.A0A0D2Q796"/>
    <dbReference type="Gramene" id="KJB12726">
        <property type="protein sequence ID" value="KJB12726"/>
        <property type="gene ID" value="B456_002G032900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775584"/>
    <dbReference type="eggNOG" id="ENOG502RZG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWMIFAG"/>
    <dbReference type="OrthoDB" id="496093at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009654">
        <property type="term" value="C:photosystem II oxygen evolving complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006814">
        <property type="entry name" value="PSII_PsbR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34369">
        <property type="entry name" value="PHOTOSYSTEM II 10 KDA POLYPEPTIDE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34369:SF2">
        <property type="entry name" value="PHOTOSYSTEM II 10 KDA POLYPEPTIDE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04725">
        <property type="entry name" value="PsbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="11" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="143" mass="14665" checksum="15B0D11A0CF0A6BD" modified="2015-04-29" version="1">MAASVMASSSSVRLKPNFNVDKSGGSRGVPSLARVPSSFKVEAGSGKKKIKTDSPYGINGGLNLKDGVDASGRRAKGKGVYQFVDKYGANVDGYSPIYDPNDWSPSGDVYTGGTTGLAIWAVTLAGILAGGALLVYNTSALAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q798</accession>
    <name>A0A0D2Q798_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_006G106900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Magnesium transporter that may mediate the influx of magnesium.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q798"/>
    <dbReference type="Gramene" id="KJB35251">
        <property type="protein sequence ID" value="KJB35251"/>
        <property type="gene ID" value="B456_006G106900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35252">
        <property type="protein sequence ID" value="KJB35252"/>
        <property type="gene ID" value="B456_006G106900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35253">
        <property type="protein sequence ID" value="KJB35253"/>
        <property type="gene ID" value="B456_006G106900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35254">
        <property type="protein sequence ID" value="KJB35254"/>
        <property type="gene ID" value="B456_006G106900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35255">
        <property type="protein sequence ID" value="KJB35255"/>
        <property type="gene ID" value="B456_006G106900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799167"/>
    <dbReference type="eggNOG" id="KOG2662">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QNSSPDY"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000009">
        <property type="entry name" value="Magnesium transporter MRS2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000001">
        <property type="entry name" value="Magnesium transporter MRS2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF26">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB35253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="49554" checksum="368A05C018E37FA6" modified="2015-04-29" version="1">MADLKERLLPLKPQSAINLRGTTSQASASGRQPFQGLDLSGLKKRGQGLRSWIRVDTSGNSQVIEVDKFTMMRRCDLPARDLRLLDPLFVYPSTILGREKAIVVNLEQIRCIITADEVLLLNSLDSYVLQYVVELQRRLTSGVGEVWQPEGPELNRRSCRNFDNVYGSPSPDYLPFEFRALEVALESACTFLDSQAAELEVEAYPLLDELTSKISTLNLERVRRLKSRLVALTRRVQKVRDEIEQLMDDDGDMAEMYLSEKKSRMECDQSMMGFRSNDGLSVSAPVSPVSSPPESRRLEKSLSMARSRHESTKSSESATESIEELEMLLEAYFVLIDSTLNKLTSLKEYIDDTEDFINIQLDNVRNQLIQFELLLTTATFVVAIFGVVTGIFGMNFAIPFFDDPGAFKWVLIITGVCGIIIFCAFVWFFKYRRLMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8U8</accession>
    <name>A0A0D2Q8U8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G191400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8U8"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8U8"/>
    <dbReference type="Gramene" id="KJB15694">
        <property type="protein sequence ID" value="KJB15694"/>
        <property type="gene ID" value="B456_002G191400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785858"/>
    <dbReference type="eggNOG" id="KOG3353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVNHAPC"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000005">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_uL22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057265">
        <property type="entry name" value="Ribosomal_uL22_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003260">
        <property type="entry name" value="PRK04223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF47">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="20187" checksum="0B8C3C12CD83ADFA" modified="2015-04-29" version="1">MVKYSKESDNPTKSCKARGSDLRVHFKNTRETAFAIRKLPLGKAKRYLEDVMAHKQAIPFRRFCGGVGRTAQAKNRHSNGQGRWPVKSAKFILDLLKNAESNAEVKGLDVDALYISHIQVNQAQKQRRRTYRAHGRINPYMSSPCHIELILSEKEEPVKKEPETQLAASKSKKSQVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QC16</accession>
    <name>A0A0D2QC16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G255400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QC16"/>
    <dbReference type="Gramene" id="KJB16934">
        <property type="protein sequence ID" value="KJB16934"/>
        <property type="gene ID" value="B456_002G255400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0626">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MITHYVD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF196">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB16934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="33376" checksum="12EB4323EE77D7A0" modified="2015-04-29" version="1">MITHYVDFCFKTFGDRVKTWMTFNEPRVVVALGFDNGINPPNRCSKQFGNCTNGNSATEPYIAAHHLILSHAEAVERYREKYQAKENGRIDIFLDFVWYEPLTRSKADYYAAQRAKDFHVGWFWHPLVYGKYPRTMQKIVRERLSKFTKSEVEKVKNSFDILCLNHYTSYHIYDPHRPPSNVTDYQQDWNVGFVYERNGVPIDQAHSKWLYEVPWGMYKAVTYVKERYGRMDDPDNLTFPKSLHDSNRVNFYKSYLKDLKRAMDDGANITGYFAWSILVNFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCC0</accession>
    <name>A0A0D2QCC0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G260700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QCC0"/>
    <dbReference type="Gramene" id="KJB17019">
        <property type="protein sequence ID" value="KJB17019"/>
        <property type="gene ID" value="B456_002G260700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB17019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="71" mass="8111" checksum="5C2F83C360ACB612" modified="2015-04-29" version="1">MFPNMILPKMNPIEPINATNTGCNKLTPKYKIKTKLATLKHNRKVTGILGLHLLVQPFNKALYQIFKLFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCJ1</accession>
    <name>A0A0D2QCJ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G265900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QCJ1"/>
    <dbReference type="STRING" id="29730.A0A0D2QCJ1"/>
    <dbReference type="Gramene" id="KJB17109">
        <property type="protein sequence ID" value="KJB17109"/>
        <property type="gene ID" value="B456_002G265900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR08">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNQANEP"/>
    <dbReference type="OrthoDB" id="523541at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037471">
        <property type="entry name" value="TIC56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37755">
        <property type="entry name" value="PROTEIN TIC 56, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37755:SF1">
        <property type="entry name" value="PROTEIN TIC 56, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14237">
        <property type="entry name" value="GYF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="2">
        <location>
            <begin position="241"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="509" mass="59616" checksum="F467429C3D2249B1" modified="2015-04-29" version="1">MASIKFDAFESWFRKPQNPIQPINLLSLTQSFLPTTSSNSPNFASISSSGFFSRKPKKPGLDSDKPGPYKQMVDQFFWECENLPDYRHTPEVENFLNEDPFFENKENPTEDELKENEKWWQDFRASPVVQFLARAEEIADEINRIELKENEEPFRKEDKKLWQAVPHVIGLDGRPMPRKAIKTREESDDKFWDFTKQFFFGLWGFRQRPYPPGRPIDVAQAIGYKRLEKRYYDFIMRSGGWYYKDRLGRTRGPCELITLKTAWGGGIIDKHTFIWGEDMDEWAPIHMVYGLEPAIATWEVRLGAAATAFLHKLQKGIPPWVPLKGHEEKTYKQLQEEAIESKRRDLAVLKANDGIWPGVRIPSHALFLWASGSEMTTLLESDHMPNKYISKDLRRKLAKVIPGLRPWEVLSVEQAMDDITYSGEWYREPLGTYTTGPPYIRHWNKDVKRIFRIFYNLSHQVYNKLERTIPGFNAIMEKVQADANARETRRKEKREAQKKVKDAAIYNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEU6</accession>
    <name>A0A0D2QEU6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G126700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEU6"/>
    <dbReference type="STRING" id="29730.A0A0D2QEU6"/>
    <dbReference type="Gramene" id="KJB56597">
        <property type="protein sequence ID" value="KJB56597"/>
        <property type="gene ID" value="B456_009G126700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768850"/>
    <dbReference type="eggNOG" id="ENOG502S77S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWKGPGQ"/>
    <dbReference type="OrthoDB" id="1676631at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="126"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB56597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="241" mass="26622" checksum="6D7F0AC4F42AA956" modified="2015-04-29" version="1">MLSMSLGVSFSGLLHCIAESVDLVLSELIDQNSVKLLRKFLPRKKIELASPEMGLDSEFKNFKAAYSSSCKHATSSSADSIMKQEHLFPDLRNEGSWSSKEELNQSGVIISHPRKRVCSNFCKGKAVLQASEAEDLNTRLEILEEESQIMKQALLETMAERKKLVNEIYKLLETRRYTLLPKAQEDGHTFSSGSLIIKPWKGPGQGTAESSLLHALLENPRSGDPNANALAILGQSCTSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QG87</accession>
    <name>A0A0D2QG87_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G251400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QG87"/>
    <dbReference type="STRING" id="29730.A0A0D2QG87"/>
    <dbReference type="Gramene" id="KJB38358">
        <property type="protein sequence ID" value="KJB38358"/>
        <property type="gene ID" value="B456_006G251400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800627"/>
    <dbReference type="eggNOG" id="ENOG502QSDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENFRVME"/>
    <dbReference type="OrthoDB" id="767438at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021916">
        <property type="entry name" value="DUF3527"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31390">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31390:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12043">
        <property type="entry name" value="DUF3527"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB38358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="618" mass="68078" checksum="093407BAC0EAA59C" modified="2015-04-29" version="1">MDGMLVTDRKDEQGNDDSLQNGDLSVGENGMNNSELKLKKLARKVNPWHALMLNVKRLQGRKNLIKDLLQRSIFDISHKIPRHVVTLDERYLRRCLELIHINAAKAARCNISVNLSSLNMGVLSDGLNSTKIRDEDTCDFDRFVFDCPLAVETGSVVLGPADPWVVGSIMGSNSMANILKSPLLQKLGVSNVDSSLMDIKGSKISSDFTNSLGGFMNYSSNKLGSETPVLDTRNGSETVQKRLVSVSSSNSSCSDQSFSSNSTTISQGMLQCTWKGGILYFVFSLDNQRVVYVANLLKDGSARNRGLGYTYLFRSSKGGHKEHGINDNDLHLVGKMKVSTSFTIGPLDSKVMETEFVLFDGNQTFNLEPQTSSHNHGKNKGISKKVAEVFKNTHLSKQRTISRYRRSISLIEDSSSDPINNSDALDRLNLLDEQLPPNFESLAIITRDHFPENPHSEVGGWGLKFLKKTGVKQKIDPSDCYTGDCSTSMDIIVPAGIHGGPRIQNGGPSSLIERWRSGGHCDCGGWDLGCPVKVLQARSSKKDGIPPTEIFEACKLFDFFIQGSEHGSPTLSISNVHDGLYFIHFQPSLSALQSFSIAVAYIHTRSPTLRPKNVQRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGF0</accession>
    <name>A0A0D2QGF0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G064200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGF0"/>
    <dbReference type="STRING" id="29730.A0A0D2QGF0"/>
    <dbReference type="Gramene" id="KJB18639">
        <property type="protein sequence ID" value="KJB18639"/>
        <property type="gene ID" value="B456_003G064200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
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        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF257">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB18639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="346" mass="37848" checksum="7D773FEF3B70E698" modified="2015-04-29" version="1">MSTPLEHDYIGLSETSSVERSSDKIPSSSSSSSSSTHPNEDKTTRTSLNLKGTELRLGLPGSQSPERKVSLFCKDLESNERSNGFAVSPLKNLMSGAKRGFSDAIDGPNGKWVFPMNGKCDVELAKGAILASPRAVLEGKNKLPSGREVGGLPQSPKPVQDKNILVPSANEHSNAPASKAQVVGWPPIRSFRKNTMASNSAKNSEDAAGCLYVKVSMDGAPYLRKVDLKTYKTYKEISSALEKMFTCFTLGHCSSNGLAVRDGLSESRLMDLLHGSEYVLTYEDKDGDWMLVGDVPWEMFIDTCKRLRIVKGSEAIGLGIWFRSSLFLDQLFRCILMVDIDDFMNS</sequence>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001741">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0581353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QHY0"/>
    <dbReference type="Gramene" id="KJB16506">
        <property type="protein sequence ID" value="KJB16506"/>
        <property type="gene ID" value="B456_002G235600"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33356:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33356">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB16506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0581353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="229" mass="26292" checksum="D0B36F92E0A9BB51" modified="2015-04-29" version="1">MANNFSNSPPNLDDGELWLPSDIFVHEPPSKFNPRLHHHHLPFTCMDELAPRFAALSLPKHHQKLPKVTNFQRLKEPVRYGSVHGAGLGQNSYGFRNGPFLAGTKPVYEFQFLKPTQAQVESYVEARVRSLQRQQQNRLFQNRGLPFEANGFNNYKLGLGGGLVRESGGTGVFHPRIVNTPFDSTKKQSMRNRQPQEMMKSMKRVGVVKQEDCYYNLPPEMGFHRDRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIX6</accession>
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        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="8" type="ORF">B456_001G007000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QIX6"/>
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        <property type="protein sequence ID" value="KJB07195"/>
        <property type="gene ID" value="B456_001G007000"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000978">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000092">
        <property type="entry name" value="transcription factor bHLH68 isoform X1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
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    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF342">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="216"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB07195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="386" mass="42289" checksum="A1352F1C188D9276" modified="2015-04-29" version="1">MNQGVLQSSPVQQLMAGNPDWWSINNAMRPPSTHHHHHHQQTASPFFPFPPPQPPPPPAAAAAAATFFPQLIPTSTSSSSSWHDNNNQEVPEPWSQLLLGGLVGEEQATALQHQASTGNNNIMKQENYVYGHANEDYHHHHHHHYQGSKATTNWSMATASSSPKSCVTTSFNNNMLDFSSNIKVDTATRQHPPLMDPSPECNSSTASGGALKKTRVQPSATQSTFKVRKEKLGDRITALHQLVSPFGKTDTASVLLEAIGYIRFLQSQIEALSLPYLGSDGSSGNMRQQQQSVQGERNCIFPEDPGQLLNEKCMKKRKGGPADLQDSNEEPKKNLKSRGLCLVPISCTLQVGSDNGADYWAPPSLGFLGKAIAKHTLKEKKKQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLJ2</accession>
    <name>A0A0D2QLJ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Sucrose synthase</fullName>
            <ecNumber evidence="2 6">2.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G047100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Sucrose-cleaving enzyme that provides UDP-glucose and fructose for various metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an NDP-alpha-D-glucose + D-fructose = a ribonucleoside 5'-diphosphate + sucrose + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16241"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:76533"/>
            <dbReference type="EC" id="2.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyltransferase 1 family. Plant sucrose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.13" evidence="2 6"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLJ2"/>
    <dbReference type="STRING" id="29730.A0A0D2QLJ2"/>
    <dbReference type="Gramene" id="KJB40108">
        <property type="protein sequence ID" value="KJB40108"/>
        <property type="gene ID" value="B456_007G047100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802152"/>
    <dbReference type="eggNOG" id="KOG0853">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DPNNGDQ"/>
    <dbReference type="OrthoDB" id="937291at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016157">
        <property type="term" value="F:sucrose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005985">
        <property type="term" value="P:sucrose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.330:FF:000001">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000006">
        <property type="entry name" value="Sucrose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000368">
        <property type="entry name" value="Sucrose_synth_GT-B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012820">
        <property type="entry name" value="Sucrose_synthase_pln/cyn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056736">
        <property type="entry name" value="SUS_EPBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056735">
        <property type="entry name" value="SUS_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02470">
        <property type="entry name" value="sucr_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45839:SF24">
        <property type="entry name" value="SUCROSE SYNTHASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00862">
        <property type="entry name" value="GT-B_Sucrose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24862">
        <property type="entry name" value="SUS_EPBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24861">
        <property type="entry name" value="SUS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase EPBD" evidence="12">
        <location>
            <begin position="159"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose synthase first GT-B" evidence="10">
        <location>
            <begin position="269"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="568"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="817"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB40108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="886" mass="100318" checksum="880BA5D015282B29" modified="2015-04-29" version="1">MASRQSLKRSDTIAESMPDALMQSTSHMKICFSRLVESGKRLLKRQQLMDEVENSIEDKAERSKILEGLIGFILVSTQEAAVIPPYVAFAVRPNPGFWEFVKVNSENLLVDEIKVSEYLKCKEMVFDQNWAKDENALEIDFASINHSTPHLTLPSSIGNGASYISKFMFSKLYESCDGEKQVLDYLLSLNHQGEDLLINGNLNTVDKLKTALRAAISIISELPKTTPYENFEPRLKELDFEKGWGDNAERAKESMMTLYEVLQMPEPANFESLFSWLPAVLRIVILSPHGYFGQSDVLGLPDTGGQVVYILDQVRALEEALLRRIKSRGMTVKPQIVVVTRLIPDARGTKCNQEIEPIINTKHSHILRVPFRTDKGVLQQWVSRFDIYPYLETFAQDAQAKVLQHMGCKPDLIIGNYSDGNLVASLMASNLGITQGTIAHALEKTKYEDSDVKWKEVDAKYHFSCQYTADILAMNAADFVITSTYQEIAGSTEKPGQYESHTAFTMPGLCRVVSGINIFDPKFNIVAPGADQSVYFPYTEKNRRLSSFYPAIEELLYSQDDNNEHIGYLADRRKPIIFSMARLDTVKNITGLTEWYGKNKRLRDLVNLVVVAGFFDPSKSNDREEQAEIKKMHSLMEQYQLRGQFRWIAAQTDRHRNGELYRCIADTKGAFVQPALYEAFGLTVIEAMNCGLPTFATNKGGPAEIIVDGVSGFHIDPNNGDQSSNTIADFFEKCKMDAQHWNRVSTQGLHRIHECYTWEIYANKLLNMGSMYGFWRQLNKEQNLAKQRYIQLLFNLQFRKLSKTVPVPREQALVSVPVPPETPKPDTVPAPAPDAGQPKSQPAVPGPKRSPSLRNMDGSLMELCVIVGFFYLVYYFIKKLFYGLMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNI8</accession>
    <name>A0A0D2QNI8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G261600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNI8"/>
    <dbReference type="Gramene" id="KJB59572">
        <property type="protein sequence ID" value="KJB59572"/>
        <property type="gene ID" value="B456_009G261600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769903"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASHFACF"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF258">
        <property type="entry name" value="LACCASE-12-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249549" description="Plastocyanin-like domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB59572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32571" checksum="F9912130A0B62DA4" modified="2015-04-29" version="1">MGSEKQGFIWLSGLLFLNIFVLSTADVHYYEFSLQESPFTKLCSTKIILTLNGSFPGPEIRVRRGDTVFVNVHNQGNHAVSLKWEGVKGSIDGSNELIQPGRNFTYKIELKDEIGTLRWHATSAWAAATVHGAFVILPVATEDYPFPAPTSDQTIILGEWFREELTEANQTITPGSADAYTINGHPGETYGCSNDTTFEMQVDYEGLYLVGVINAVANETMVFDIENHRLTIVGQNGTYTNRSFTNSLTLAPGQVIDVLLLPNQNVGHYYITARSSSGTHITNGILRYTTTTTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNR0</accession>
    <name>A0A0D2QNR0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G267200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNR0"/>
    <dbReference type="STRING" id="29730.A0A0D2QNR0"/>
    <dbReference type="Gramene" id="KJB59677">
        <property type="protein sequence ID" value="KJB59677"/>
        <property type="gene ID" value="B456_009G267200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59681">
        <property type="protein sequence ID" value="KJB59681"/>
        <property type="gene ID" value="B456_009G267200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59682">
        <property type="protein sequence ID" value="KJB59682"/>
        <property type="gene ID" value="B456_009G267200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="3">
        <location>
            <begin position="675"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="878"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="801"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB59682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="934" mass="105967" checksum="640C856F99AD6660" modified="2015-04-29" version="1">MAESVANPTVVGASTVEETSPDLLKNTPSNIARLEDVIEHCKGRRKYLAQTRSPSDGGDVRWYFCKVPLAENELAASIPRTEIVGKSDYFRFGMRDSLAIEASFLQREEELLSSWWKEYAECCEGPRGRSSSGKKLDLGEDSSSSKGLQSAQLYGFEEERVGVPVKGGLYEVDLVKRHCFPVYWNGENRRVLRGHWFARKGGVDWLPLREDVAEQLEIAYSNKVWHRRTFQPSGLFAARVDLQGSTPGLHALFTGEDDTWEAWLNVDASGFSSVISFGGSAIKLRRGYSASHSPKPTQDELRQRREEEMDDYCSEVPVRHLVFMVHGIGQRLEKSNLVDDVGNFRHITATLAEKHLTSHQRRTQRVLFIPCQWRKGLKLSGEAAVEKITLDGVRGLRVMLSATVHDVLYYMSPIYCQSIINSVSNQLNRLYLKFLKRNPGYDGKVSIYGHSLGSVLSYDILCHQENLSSPFPMEWVYEKHSKDVGCPVDTNNQSSNPSSLDNLEENNINVRMKDAVDCVGEDMLVSQPTALVIEGNVEDESLVNSEIDVSAEDSIQKSCEEDVHRLLNDFSGTLLLDEGGLGKATDVAGLSEKVTEEESEEARDKDKEIKMLREEVNSLEAKIAELQSHKSEDTTENKEMLVRKPPSLQKFDQKLVVTLDDAPQRYTPYIRYTKLEFKVDTFFAVGSPLGVFLALRNIRIGLGKGQDYWDEENISEEMPACRQMLNIFHPYDPVAYRIEPLVCKEHITKRPVIIPYHKGGRRLHIGFQEFTEDLAARSQGVMDRLSFIRAKVLTVCQSRNTDDLEGPKNMEEKEERPYGSQMIERLTGSEEGRIDHMLQDKTFEHPYLQAIGAHTNYWRDYDTALFILKHLYRDIPEDPDSSMESNGDSSKDKSVFTGWSDHRGSPDEESPLTFSDRIMVKSFSREAKKFVKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSE5</accession>
    <name>A0A0D2QSE5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_001G186000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the targeting and/or fusion of transport vesicles to their target membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Early endosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSE5"/>
    <dbReference type="SMR" id="A0A0D2QSE5"/>
    <dbReference type="STRING" id="29730.A0A0D2QSE5"/>
    <dbReference type="Gramene" id="KJB10140">
        <property type="protein sequence ID" value="KJB10140"/>
        <property type="gene ID" value="B456_001G186000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799042"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YSCDSHT"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000002">
        <property type="entry name" value="Vesicle-associated membrane protein 722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000010">
        <property type="entry name" value="Vesicle-associated membrane protein 726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="14">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB10140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24544" checksum="AA749E5EECC0390F" modified="2015-04-29" version="1">MGQQSLIYAFVARGTMVLADYTEFTGNFTGIASQCLQKLPASNNKFTYNCDGHTFNYLVDNGYTYCVVAVESVGRQVPIAFLERIKEDFTKRYGGGKAATASANSLSKEFGPKLKEHMEYCIDHPEEISKIAKVKAQVSEVKGVMMENIEKVLDRGGKIEILVDKTENLRSQAQDFRQQGTRMRRKMWLQNMKVKLIVLGILIALILIIVLSICGGFHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QTP0</accession>
    <name>A0A0D2QTP0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G158700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QTP0"/>
    <dbReference type="STRING" id="29730.A0A0D2QTP0"/>
    <dbReference type="Gramene" id="KJB42583">
        <property type="protein sequence ID" value="KJB42583"/>
        <property type="gene ID" value="B456_007G158700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803334"/>
    <dbReference type="eggNOG" id="KOG0554">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REQYEWY"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF36">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class II (D/K/N)" evidence="9">
        <location>
            <begin position="360"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="627" mass="69733" checksum="2B7A270EC5223389" modified="2015-04-29" version="1">MESQEPQVKNSPLMPSMYTNRVALKTILESGDGETGLIGTTVVVGGWVKSSKEVKKEPLPPPQSPPPAAADAFPAASHGTKDVNCVEILQSRIPFFRTIIRVLGGSASSPAVRQKLESLIPKPPPPSIFFLDINDGSCVSSLRVVIDSAIVPVSAGQILPTGTCILAQGVLGNPSALGKQTIELTVEKILHVGTVEQDKYPLSRKRLPLDSLRDYPHIRPRTTTVASVARIRNTLDFASHTFFQNRGFLHVQVPIMTTTDPEGFSEKFQVTTLLGETSKKESPVGVSDADGVNPETVKAAIQEKSSLVEQLKRSDSNREALAAAVQDLKKTNELAQQIETREKSKPVTAVKPDLVSFNADFFGRQIYLTVSGRLHLESYACALGHVYSFGPRFRADKTVSAKHVAEMWTVEAEMAFAQLEDAMKCAEDCFKFLCRWILDNCSEDMKFVLKRIDKTVAHRLEYMASSSYDRISYREAVEILRKVTDKAFETQLQWGVPLTDEHLSYLADDHYRRPVIIYDYPKAVKPFYVRLNDDGKTVAAFEMVVPKIGTVIIGSQNEERFDMLNARIKEFDLSKDQYEWYLDLRRHGTVKHSGLSLGFDLMVLLATGLTDVRDVIPFTRTHGKANN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QU11</accession>
    <name>A0A0D2QU11_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">UDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="12">4.2.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G362500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:21500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:85329"/>
            <dbReference type="EC" id="4.2.1.76"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">In the C-terminal section; belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.76" evidence="12"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QU11"/>
    <dbReference type="STRING" id="29730.A0A0D2QU11"/>
    <dbReference type="Gramene" id="KJB61502">
        <property type="protein sequence ID" value="KJB61502"/>
        <property type="gene ID" value="B456_009G362500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766306"/>
    <dbReference type="eggNOG" id="KOG0747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050377">
        <property type="term" value="F:UDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010280">
        <property type="term" value="F:UDP-L-rhamnose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010253">
        <property type="term" value="P:UDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000236">
        <property type="entry name" value="Bifunctional dTDP-4-dehydrorhamnose 3,5-epimerase/dTDP-4-dehydrorhamnose reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="15">
        <location>
            <begin position="10"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RmlD-like substrate binding" evidence="14">
        <location>
            <begin position="384"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="357"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB61502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="667" mass="75123" checksum="AA4B613C9D6D39EF" modified="2015-04-29" version="1">MATYTPKNILITGAAGFIASHVANRLVRNYPDYKIVVLDKLDYCSNLKNLIPSQSSPNFKFVKGDIGSADLVNYLLITESIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFIHVSTDEVYGETDEDAVVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKLIPKFILLAMRGKVLPIHGDGTNVRSYLYCEDVAEAFEVILHKGEVGHVYNVGTKKERRVIDVAKDICKLFSMDPETSIKFVENRPFNDQRYFLDDQKLKNLGWSEQTVWEDGLKKTIEWYTQNPDWWGDVSGALLPHPRMLMMPGGRQFDSEEGKDTSYISSPNQTQMVVPTSKSSVSSQKPALKFLIYGRTGWIGGLLGQLCDKQGIPFEYGKGRLEDRSSLTADIRNIKPTHVFNAAGLTGRPNVDWCESHKTETIRTNVAGTLTLADVCREHGLLMLNFATGCIFEYDAGHPQGSGIGFKEEDIPNFTGSFYSKTKAMVEELLKEYNNVCTLRVRMPISSDLNNPRNFITKISRYSKVVNIPNSMTILDELLPISIEMAKRNLTGIWNFTNPGVVSHNEILEMYKKYIDPKFQWANFTLEEQAKVIVAPRSNNEMDASKLKKEFPELLPIKESLIKYVFEPNKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYB0</accession>
    <name>A0A0D2QYB0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">Peroxidase</fullName>
            <ecNumber evidence="4 18">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_007G238800</name>
        <name evidence="21" type="ORF">Gorai_019411</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 18">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYB0"/>
    <dbReference type="STRING" id="29730.A0A0D2QYB0"/>
    <dbReference type="Gramene" id="KJB44183">
        <property type="protein sequence ID" value="KJB44183"/>
        <property type="gene ID" value="B456_007G238800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804216"/>
    <dbReference type="eggNOG" id="ENOG502R50X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
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    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
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    <dbReference type="FunFam" id="1.10.520.10:FF:000009">
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    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
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    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
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    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
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    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
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    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF147">
        <property type="entry name" value="PEROXIDASE 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="18" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="7 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0964">Secreted</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
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    <feature type="chain" id="PRO_5034010806" description="Peroxidase" evidence="18">
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            <begin position="23"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="23"/>
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    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="68"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="70"/>
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        <ligand>
            <name>Ca(2+)</name>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="83"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
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        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="33"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="115"/>
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        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="193"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB44183.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0590717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="321" mass="34996" checksum="B9FF889878900F49" modified="2015-04-29" version="1">MSSFQMITTLFLLAMMVGTSNSQLSATYYAKTCPNASSIVRSVLQQAEQNDIWIFPKLIRLHFHDCFVHGCDASLLLNGTDSEKTATPNLSTDGYAVIDDIKTALEKACPRVVSCADILALAAQISVSLGGGPTWKVPLGRRDSRTAHREGTGTIPTGHESLANIATLFKSMGLDSTDLVALSGVHTFGRARCAAFMDRLYNFNNVSGKIDPILNGTYAKTLRQLCPKGGDVTSLIDLDEQTSLTFDNKYFLNLQNRRGLLQTDQELFSTKGAETVAIVNRFASSQSQFFNSFAKAMIKMGNINPLTGTNGEIRLDCRKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYG2</accession>
    <name>A0A0D2QYG2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="12">MICOS complex subunit MIC60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G242500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB44253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QYG2"/>
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        <property type="protein sequence ID" value="KJB44253"/>
        <property type="gene ID" value="B456_007G242500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804263"/>
    <dbReference type="eggNOG" id="ENOG502QTA5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10261039at2759"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="144"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="378"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB44253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="679" mass="74120" checksum="D6A4B75EF0135663" modified="2015-04-29" version="1">MLRRSILELSRHRGSPRRIPRQIISQCSSPFLYSRKQFSTSPGENPTPKPGSAGGPPESNSGFSRVVLGSAVIVGAALVAYQAGYLDQYFGQVPNDSVDSAKIGFDSKDENDVQVVTSHDEEIKGQTTHLDLHEQEDATRISLPPQLETSSETPSVNHPNVEVKSNDSNETLGNSSTSGPEKPLPEYSQSSLPSADHSADAAVSAEGNVEKAGSETAPIPDKEIHDIQLDTQSSASLGEKETKAVEPHSHATEDRPQDETSKGAEAPSFALEESEIKAVPFLHPSIADISQAKPTEDKGAPSSLLDAYHLRDKADDSYLSSLNRKYEQLSKETEGFGTAVEELNEGYLSKDGKLILGFLQAIHAAEKWQAELDAHAFAQEKEVLKEKYEKELRNSRARELMRTEEAAILDKELKRERTKAAAALKSLQEKMEEQLRMELEEKEREAELKLQKAQELGKAELAAAIANEKAAQIEKLAEANLNINALCMAFYARSEEAHKSHSVHKLALGALALEDALSKGLPIQKEIDALRTYLEGTEKDSVLDLVLSSLPEETRYHGTDTVLQLNQKFNALKGTLRHFSLIPPGGGGILTHCLAHIASWLKVKEVDQSGEGIESLISRVDKYLAEGKLAEAATALEQGVKGSQAEEIVNDWVKQARNRAITEQALTALQSYATCISLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYG3</accession>
    <name>A0A0D2QYG3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G157300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYG3"/>
    <dbReference type="STRING" id="29730.A0A0D2QYG3"/>
    <dbReference type="Gramene" id="KJB24709">
        <property type="protein sequence ID" value="KJB24709"/>
        <property type="gene ID" value="B456_004G157300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791592"/>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCACDKT"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09440">
        <property type="entry name" value="LIM1_SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="102"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB24709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="207" mass="23087" checksum="EFD81B93D292216F" modified="2015-04-29" version="1">MAFTGTLDKCKACDKTVHVVDMLTLEGVPYHKTCFKCSHCKGNLVMSTYSSMDGVLYCKPHFEQLFKESGNFSKNFQTSKERQIDQVKTPNKLSSLFCGTQDKCAACHKTVYPLEKVTMEGECFHKTCFRCAHGGCALTHSSYAALDGVLYCKHHFAQLFMVKGNYAHVLQAASHKRNNSSASPKLAENQADQRETATDEDDSEDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYX6</accession>
    <name>A0A0D2QYX6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zinc-ribbon 15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G017300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYX6"/>
    <dbReference type="STRING" id="29730.A0A0D2QYX6"/>
    <dbReference type="Gramene" id="KJB12425">
        <property type="protein sequence ID" value="KJB12425"/>
        <property type="gene ID" value="B456_002G017300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787140"/>
    <dbReference type="eggNOG" id="ENOG502S6S3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYCRSWR"/>
    <dbReference type="OrthoDB" id="1872195at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33320">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33320:SF2">
        <property type="entry name" value="OS07G0564200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7645" checksum="13D226A23111A8A6" modified="2015-04-29" version="1">MVFFCFLVDQTKKVSTTKPAAGICSRCGGGARVADMKTSTRFCYVPFYKKSWRAIICTFCGAILRSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZ82</accession>
    <name>A0A0D2QZ82_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G1391002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZ82"/>
    <dbReference type="STRING" id="29730.A0A0D2QZ82"/>
    <dbReference type="Gramene" id="KJB63237">
        <property type="protein sequence ID" value="KJB63237"/>
        <property type="gene ID" value="B456_010G1391002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB63238">
        <property type="protein sequence ID" value="KJB63238"/>
        <property type="gene ID" value="B456_010G1391002"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773459"/>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEELRCF"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051106">
        <property type="entry name" value="RNA-bind/splicing_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48028:SF2">
        <property type="entry name" value="GLYCINE-RICH RNA-BINDING PROTEIN RZ1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="6">
        <location>
            <begin position="124"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="71"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="189"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB63237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22451" checksum="C0F210E7F92CC71C" modified="2015-04-29" version="1">MSEDVEYRCFIGNLSWATTDRGLKDAFEKFGNLLDAKVAVDKFSGRSRGFGFVSFDDKAAMEEAIEGMNGMDLDGRNITVDKAKPHQGSDRDSDGDRSRDHGRDHDRDRNWGYDGGRGSHGGECFKCGKPGHFARECPSDGGKYGGRVDRYGGGGGSSGRYGPDRNGDRFGGRSRDAGSRGGAGAGGDRYNRDRSGPYERRGTGGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0I0</accession>
    <name>A0A0D2R0I0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G278800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0I0"/>
    <dbReference type="STRING" id="29730.A0A0D2R0I0"/>
    <dbReference type="Gramene" id="KJB44898">
        <property type="protein sequence ID" value="KJB44898"/>
        <property type="gene ID" value="B456_007G278800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2190">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009911">
        <property type="term" value="P:positive regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22461">
        <property type="entry name" value="KH-I_PEPPER_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22459">
        <property type="entry name" value="KH-I_PEPPER_rpt1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22460">
        <property type="entry name" value="KH-I_PEPPER_rpt2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.210:FF:000002">
        <property type="entry name" value="KH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000127">
        <property type="entry name" value="RNA-binding KH domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="160"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="252"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="431"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="419"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB44898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="550" mass="59653" checksum="546F1CF4539497EF" modified="2015-04-29" version="1">MDFDEFVRTTLMAEVGQSYGENEVEQVQEHVDLEQNLNLGHDLNLEHSANLEQNANLEHIANLEHMANLEHNANLEHIANLQQIANLEHNANLEHIANLEHNANLEHSVDSEQNLNLEEEPEENLEEQKLQQESQHQPKQDHENEAVVGGGEKKWPGWPGESVFRMLVPAQKVGSIIGRKGEFIKKIVEETRARIKILDGPPGTTERAVMVSGKEEPDSSLPPAMDGLLRVHKRLIDGLEGDSSHAPSAVGTKVSTRLLVPAPQAGSLIGKQGATVKTIQESSNCIVRVLGSEDLPVFALQDDRIVEVVGEAADVHKALELIASHLRKFLVDRSIIPLFEMHMQKSNPQMDHMPPRQTWAPPQGVPPNAGGGGFGHNPQYMPPPRQLENYYPPADMPPMDKQPHQGISAYGREAPTGAHGSSNPNAPSMITQVTQQMQIPLSYADAVIGTAGASISYIRRVSGATVTIQETRGVPGEMTVEISGTASQVQTAQQLIQNFMAEAAAPAQAQVGGAADQAYNPYAAHGSLYASPPSNPGHAGGYGYGSNYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4E2</accession>
    <name>A0A0D2R4E2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Catalase</fullName>
            <ecNumber evidence="4 15">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_002G115900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="4 15"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4E2"/>
    <dbReference type="SMR" id="A0A0D2R4E2"/>
    <dbReference type="STRING" id="29730.A0A0D2R4E2"/>
    <dbReference type="Gramene" id="KJB14250">
        <property type="protein sequence ID" value="KJB14250"/>
        <property type="gene ID" value="B456_002G115900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783611"/>
    <dbReference type="eggNOG" id="KOG0047">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNSYGRW"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009514">
        <property type="term" value="C:glyoxysome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009845">
        <property type="term" value="P:seed germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08154">
        <property type="entry name" value="catalase_clade_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000002">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF23">
        <property type="entry name" value="CATALASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="9 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="7 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 15" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="17">
        <location>
            <begin position="18"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
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            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB14250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="492" mass="56817" checksum="9BF9BA3FD5A2BA1D" modified="2015-04-29" version="1">MDPYKHRPSSAFNSPFWTTNSGAPVWNNNSSLTVGPRGPILLEDYHLVEKLANFDRERIPERVVHARGASAKGFFEVTHDISHLTCADFLRAPGVQTPVIVRFSTVIHERGSPETLRDPRGFAVKFYTREGNFDLVGNNFPVFFIRDGMKFPDMVHALKPNPKSHIQENWRILDFFSHHPESLHMFTFLFDDLGVPQDYRHMEGSGVNTYTLINKAGKAHYVKFHWKPTCGVKCLLEDEAIKVGGANHSHATQDLYDSIAAGNYPEWKLFIQTIDPDHEDKFDFDPLDVTKTWPEDILPLQPVGRLVLNKNIDNFFAENEQLAFCPAIVVPGIYYSDDKLLQTRIFSYSDTQRHRLGPNYLQLPANAPKCAHHNNHHEGFMNFMHRDEEINYFPSRYDPVRHAEMFPIPPAVCTGRREKCIIEKENNFKQPGERYRSWAADRQERFICRWVDALSDPRVTHEIRSIWISYWSQADKSVGQKLASRLNVRPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5I3</accession>
    <name>A0A0D2R5I3_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G135700</name>
        <name evidence="3" type="ORF">Gorai_022861</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5I3"/>
    <dbReference type="STRING" id="29730.A0A0D2R5I3"/>
    <dbReference type="Gramene" id="KJB14650">
        <property type="protein sequence ID" value="KJB14650"/>
        <property type="gene ID" value="B456_002G135700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3J5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITQCAGN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016972">
        <property type="entry name" value="UCP031279"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33526">
        <property type="entry name" value="OS07G0123800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33526:SF13">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031279">
        <property type="entry name" value="UCP031279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB14650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0580652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="166" mass="18561" checksum="697BB48857663750" modified="2015-04-29" version="1">MSRKGHSHNKLVRFITIPFRALGKARDLYVKSMTSCASRVSFGQGSGDYSGQYSGLPRSFSASSATSSHDNEDLRDLIRAASVRSLGHRNEIEMFMQEQLKQMRSSKGLPKSSSVGMGRIDEDKPCDDFEEKDEAPVDNKKQDSLFKRSKTYASVTKRTSVAFDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5K0</accession>
    <name>A0A0D2R5K0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G136600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5K0"/>
    <dbReference type="STRING" id="29730.A0A0D2R5K0"/>
    <dbReference type="Gramene" id="KJB14665">
        <property type="protein sequence ID" value="KJB14665"/>
        <property type="gene ID" value="B456_002G136600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2142">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIWFSVK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB14665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="131" mass="15390" checksum="9F2D9A20321708DE" modified="2015-04-29" version="1">MSLQNPHSEAGIHAVKIYGPKVMFDRGPTVAFNVFDWKGERIDPALVQKLTNRNNISLCIGCLQHIWFSVKHEEIKEKDEFQPRIDVTATIGFLTSFEDIYRLWVFVSRFLDANFLEKEKWRYKAINKKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAS3</accession>
    <name>A0A0D2RAS3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peroxisomal nicotinamide adenine dinucleotide carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G199000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAS3"/>
    <dbReference type="STRING" id="29730.A0A0D2RAS3"/>
    <dbReference type="Gramene" id="KJB67547">
        <property type="protein sequence ID" value="KJB67547"/>
        <property type="gene ID" value="B456_010G199000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774573"/>
    <dbReference type="eggNOG" id="KOG0769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TLFRGCP"/>
    <dbReference type="OrthoDB" id="965223at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="109"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="232"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB67547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37791" checksum="65ABBBB927EC86BB" modified="2015-04-29" version="1">MSDALINGLAGAGGGIIAQLITYPLQTVNTRQQTERDLKKEKRKLGTIEQMCQVVKQEGWERLYGGLTPSLVGTTASQGVYYYFYQIFRNKAESKALERQKKGIGDGSVGMLSSLIVAALSGCVNVLLTNPIWVVVTRMQTHTNILRKDHSNRLATPALEETVLSAIEPFSYSTGHAIQEVYDEAGFWGFWKGVFPTLIMVSNPAMQFMLYETMLKKLKKQRSLSKPDNNGVTALEIFLLGALAKLGATVVTYPLNVVKARLQAKQVATGDRRHQYKGTMDAILKMIRYEGFYGFYKGMSTKIVQSVLAAAVLFMIKEELVKGARLLLVKDGIHTVKSKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAX7</accession>
    <name>A0A0D2RAX7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chaperone DnaJ C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G200700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Vaslin M.F."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12996" checksum="E1372D06992B9D96" modified="2015-04-29" version="1" fragment="single">MEINEGLKAYCGGCGELLSAPCFTCSHCNYHLHKQCAEAPLSLPSHPSHPRHSYYGLFHQQRPYPSDHNVCGCAVCKEKPNTFFYECHFCYFSLDIKCAHLSSSCKFNQQSKYH</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="310" mass="34525" checksum="58A35DCD12DAA0F7" modified="2015-04-29" version="1">MPGDLAKTDSEASSLSQSSPPRSPRRQMYYVQSPSRDSHDGEKTTNSFNSTPVLSPTHSHSNSSLGPHSSRESSSTRLSKHHGSRKPRTNKQSWKEFDAIEEEALLDGEAAHHALHRRRCYFLSFLVGFFVLFTTFSLILWGASRPQKPKITMKSISFNEFVVQAGADFSGVSTEMVSMNCTVKLTYRNTATFFGVHVTSTPLHLSYSQLTVATGSIHKFYQSRKSQRALIVMMEGSHIPLYGGGASLASLNGAPTQPVPLTLDFMVRSRAYVLGKLVKPKFYKRIQCWVTMDPKKMSKAISLKNKCSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF13</accession>
    <name>A0A0D2RF13_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G034800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF13"/>
    <dbReference type="Gramene" id="KJB28216">
        <property type="protein sequence ID" value="KJB28216"/>
        <property type="gene ID" value="B456_005G034800"/>
    </dbReference>
    <dbReference type="OMA" id="RAVHQHH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01228">
        <property type="entry name" value="EGGSHELL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB28216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="475" mass="41096" checksum="BE1EA1C4232F0F55" modified="2015-04-29" version="1">MAENKRNRRSLTFLPLVGLGAVGAAATGAAALKGASALKRAVHQHHVVEGGGKGVGVGGKIGGQVEFGGKGSGIGSGNIAGGKSVGFGGNIGGQGEFGGKGSGSGSSNIASDKSIGFGGNIEGQGGFGGKGGGSGSSNIAGGVGGQGGFEGKGGGSGSANVVGGVGGQGGFVGKGDGSGSANVAGGVGGQGGFGGKGGGSGSPNVAGGVGGQGGFGGKGGGSGSGSANVDGGFRGKGEFGGKGGGTSSTNFAGGFVGQGGFKGKGGGTGSASDSANVAGGVGGQGGFKGKGGGTGSASDSANVAGGVEGQGGFGGKGGGSGSANVVGGVGGQGGFGGKGGASGSANFAGGVGGQGGFGGKGGGSSSANVAGGIKGKGGFGGSGSTNVIGGVRGQGGFDGKGGGSGSANVAGGAGGEGGFSGKGGGSGTANVAGGARGEGGFSGKGGGSGSGNLHFGGSGKFHFGLGRGGGFGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RG94</accession>
    <name>A0A0D2RG94_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G059000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RG94"/>
    <dbReference type="STRING" id="29730.A0A0D2RG94"/>
    <dbReference type="Gramene" id="KJB28626">
        <property type="protein sequence ID" value="KJB28626"/>
        <property type="gene ID" value="B456_005G059000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHPRAFV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000001">
        <property type="entry name" value="Mitochondrial transcription termination factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF166">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF15, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB28626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="417" mass="47934" checksum="C6B3381EFE1AD255" modified="2015-04-29" version="1">MFNPYSKNIIDFFKLLYNVTNNPLSNNPSLFFTIRSFSNASLDQSRSFTVSYLTNNLGFSPESALKASKCVRFKTPQNADTVIAFLEKYGFSDTQIRKIIEVRPHLLRSDLEKTILPKIHFFQSKGGANPDISKLLLHNPRLFSHSLKKLIIPCFNQLSSFLQSDSKAIIALRRNPFLIPCNFDVYMLPNVKTLLDNGVPESNITTMFNYHPRAFVMSPDQFKEIVKDVKEMGFNPLLLKFLHAVILFRKVSKSAMEGKFDVYKKWGWSDEEIWEAFRKFPGVLEPSKEKITAIMDFLVNEMGFESLIIANHPSIVSRSLEKLIVPRALFARELLSKGLIKDLRFTVVFGTSEKLLSKGLIKDLKFSVVFGTSEKLFVQRFVNQYKDKAPELLKLYEEKLKFAVRGKYKSNRASCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RMK3</accession>
    <name>A0A0D2RMK3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G163100</name>
        <name evidence="8" type="ORF">Gorai_016886</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RMK3"/>
    <dbReference type="SMR" id="A0A0D2RMK3"/>
    <dbReference type="STRING" id="29730.A0A0D2RMK3"/>
    <dbReference type="Gramene" id="KJB30835">
        <property type="protein sequence ID" value="KJB30835"/>
        <property type="gene ID" value="B456_005G163100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB30836">
        <property type="protein sequence ID" value="KJB30836"/>
        <property type="gene ID" value="B456_005G163100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794450"/>
    <dbReference type="eggNOG" id="KOG2722">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSWGYHI"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080162">
        <property type="term" value="P:endoplasmic reticulum to cytosol auxin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039305">
        <property type="entry name" value="PILS2/6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419">
        <property type="entry name" value="PROTEIN PIN-LIKES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31419:SF2">
        <property type="entry name" value="PROTEIN PIN-LIKES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0586133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="451" mass="49802" checksum="39E418F31DAAC3CE" modified="2015-04-29" version="1">MNRYLAEFYKNDMKSNSEDLLSAILPLLKLLSLTVIGLFLAHPKTQIIPRATFKLLSKLVFALFLPCLIFTELGESITIDSIARWWFIPVNVLISTFVGCLLGLLVVIICRPPPEYKRFTIVMTAFGNTGNLCLAIVGSVCHTSNSPFGPHCHSRGVAYVSFAQWVAVILVYTLVYHMMEPPLQFYEVLEEGTEIEEQRPVNDISRPLLIEAEWPGIEEKETEHSKTPFIARIFNSISSRSTSTFPDIDINGDTSGSSPMSIRCLAEPRVVRKIRIVAEQTPIQHILQPPTIASLLAIIVGTVPQLKSYVFGYDAPLSFITDSLQIVAGAMVPSVMLILGGMLAEGPNDSKLGLRTTIGIIVARLLVLPLLGIGIVTLASKLDLLVADDAMYRFVLLLQYTTPSAILLGAIASLRSYAVREASALLFWQHLFALFSLSVYVVVYFKLLPAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RP63</accession>
    <name>A0A0D2RP63_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Galectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_005G189000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Possesses hydroxyproline O-galactosyltransferase activity. Transfers galactose from UDP-galactose to hydroxyproline residues in the arabinogalactan proteins (AGPs). Is specific for AGPs containing non-contiguous peptidyl hydroxyproline residues. Utilizes UDP-galactose solely as sugar donor. The addition of galactose onto the peptidyl hydroxyproline residues in AGP core proteins represents the first committed step in arabinogalactan polysaccharide addition. AGP glycans play essential roles in both vegetative and reproductive plant growth.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RP63"/>
    <dbReference type="STRING" id="29730.A0A0D2RP63"/>
    <dbReference type="Gramene" id="KJB31391">
        <property type="protein sequence ID" value="KJB31391"/>
        <property type="gene ID" value="B456_005G189000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794725"/>
    <dbReference type="eggNOG" id="KOG2287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CDGWISK"/>
    <dbReference type="OrthoDB" id="2139606at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990714">
        <property type="term" value="F:hydroxyproline O-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010405">
        <property type="term" value="P:arabinogalactan protein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00070">
        <property type="entry name" value="GLECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000005">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000071">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase GALT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000199">
        <property type="entry name" value="Hydroxyproline O-galactosyltransferase GALT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001079">
        <property type="entry name" value="Galectin_CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF286">
        <property type="entry name" value="HYDROXYPROLINE O-GALACTOSYLTRANSFERASE GALT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00337">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01762">
        <property type="entry name" value="Galactosyl_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00908">
        <property type="entry name" value="Gal-bind_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51304">
        <property type="entry name" value="GALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Galectin" evidence="17">
        <location>
            <begin position="178"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00059439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="666" mass="76183" checksum="5C7AB4FF5FF48274" modified="2015-04-29" version="1">MKLAKFDSLVSLSRLRLVQFLMGVLFLYLLFISFEIPLVFKTTSAGFYTDALPRPLFLESEEDFTDKSAPARPTDDPELVRLAGSRTPPRRMWEYKEVSGLLFNESSFDSNDSKDEFSVLHKTARHAFVLGKKLWDDLQSPQNKSDSEPERQNQKQNRTGSCPESISLSGSEFVNRSRVLVIPCGLTLGSHITVIGMPHWAHAEYDPKIAILKEGDESVMVTQFMMELQGLKTVEGEDPPRILHFNPRLKGDWSGKPVIEQNTCYRMQWGTALRCEGWKSRAAEETVDGQVKCEKWIRDDDNGSEESKATWWLKRLIGRKNKVALDWPYPFAEGRLFVLTLSAGLEGYHVNVDGRHVTSFPYRTGFVLEDATGLSLKGDLDVHSVFAAALPTSHPSFAPQKHLERLSKWKAPPLPEGNVELFIGVLSAGNHFAERMAVRKSWVQHKLIKSSKVVARFFVALNGRKDINVELKKEAEYFGDIVIVPYMDNYDLVVLKTVAICEYGIRTVAAKYIMKCDDDTFVRVDPVIKEAKKLGGRSLYIGNMNYYHKPLRNGKWAVTYEEWPEEEYPPYANGPGYIVSSDIAQFIVDEFENHKLRLFKMEDVSMGMWVEKFNSSKAVEYQHSLKFCQFGCIEDYYTAHYQSPRQMLCMWDKLQKQGKPQCCNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRQ3</accession>
    <name>A0A0D2RRQ3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G008300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRQ3"/>
    <dbReference type="Gramene" id="KJB53858">
        <property type="protein sequence ID" value="KJB53858"/>
        <property type="gene ID" value="B456_009G008300"/>
    </dbReference>
    <dbReference type="OMA" id="CEIANHE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012438">
        <property type="entry name" value="DUF1639"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33130:SF43">
        <property type="entry name" value="OS01G0688600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33130">
        <property type="entry name" value="PUTATIVE (DUF1639)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07797">
        <property type="entry name" value="DUF1639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB53858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="177" mass="20225" checksum="BBBACF2EF0A4F945" modified="2015-04-29" version="1">MGSTNPYLSKPLHNFSLPPFSDNLVICKQRSKNRKKIIKDPQETEGSDQPNSDATQTPVSERKQKIVLNLKVRLKNSICEIANHEEPKASDQLNPHKASDVTQRRKTDHHHQPEIIVPTKKNAAALTNKKRRRVSVTLSREEIEEDIAEIAKLAGKKLQRRNPEKRPRINLDHLFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVP6</accession>
    <name>A0A0D2RVP6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_006G134300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVP6"/>
    <dbReference type="STRING" id="29730.A0A0D2RVP6"/>
    <dbReference type="Gramene" id="KJB35919">
        <property type="protein sequence ID" value="KJB35919"/>
        <property type="gene ID" value="B456_006G134300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799466"/>
    <dbReference type="eggNOG" id="KOG2788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Rambani A."/>
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                <person name="Saranga Y."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 18">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYS0"/>
    <dbReference type="STRING" id="29730.A0A0D2RYS0"/>
    <dbReference type="Gramene" id="KJB37049">
        <property type="protein sequence ID" value="KJB37049"/>
        <property type="gene ID" value="B456_006G187600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTNHFVD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000008">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF17">
        <property type="entry name" value="PEROXIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 18" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112777" description="Peroxidase" evidence="18">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="22"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="32"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="65"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="119"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB37049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="328" mass="36061" checksum="9434562796B88DA4" modified="2015-04-29" version="1">MVSPSSLFLILLFLSIPSSESNLTTDYYKNSCPHLENIIRETVTSKYISVPAAAAGTLRLFFHDCMVGGCDASVLISSNPFTKAERDADINLALPGDAFDVIVRAKTALELSCPGIVSCADILALATRNFVSMAGGPVYTVMLGRKDSLESNISSVEGNIPRANTTMDEIIRMFESKNFTVGEMVALSGAHTIGFSHCKEFAYRLFGYSRSTPTDPSYHPKFSAALKTLCANYKNDSDMAAFNDPMTPSKFDNMYYQNLKRGMGLLESDNGLLRHPRTNHFVDLYAFNQTAFSNDFARAIEKLSLSGIKTGNQGEVRRKCDAFNTFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RZ60</accession>
    <name>A0A0D2RZ60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G195000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Zhang D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB78417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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</entry>
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        <lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2SA23"/>
    <dbReference type="Gramene" id="KJB41144">
        <property type="protein sequence ID" value="KJB41144"/>
        <property type="gene ID" value="B456_007G092900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802618"/>
    <dbReference type="eggNOG" id="KOG1787">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEDTEAC"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01201">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1540.10:FF:000001">
        <property type="entry name" value="neurobeachin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046851">
        <property type="entry name" value="NBCH_WD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031570">
        <property type="entry name" value="NBEA/BDCP_DUF4704"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF157">
        <property type="entry name" value="BEACH DOMAIN-CONTAINING PROTEIN C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15787">
        <property type="entry name" value="DUF4704"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20426">
        <property type="entry name" value="NBCH_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14844">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="6">
        <location>
            <begin position="2098"/>
            <end position="2208"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="5">
        <location>
            <begin position="2223"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2669"/>
            <end position="2702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="976"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1401"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2033"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2709"/>
            <end position="2736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="976"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1401"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="2046"/>
            <end position="2059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2710"/>
            <end position="2730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB41144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2977" mass="325158" checksum="A9FC49226BBA6160" modified="2015-04-29" version="1">MEEEEEKKFGETSVKSFDTHEIGAVEDRIGGSHQDNATGGEESILKNNNAVSQEVHSATPIGDEDQFEPVSLENQDKAAGEFQDDQVDSNRSSSSDYQRQFSVMEYDSSSMSGPRHDSSASSPGPERQTDYQIKQSISETGLDSVFYADSRGSPLGSPTTSKPKAAMPNVSPELLHLVDSAIMGKSEGLDKLKNIVSGAETFESVEDMESIPFLVVDSLIATMGGVESFEENEDDNPPSVMLNSRAAIVAGELIPWLPWEGDSDILMSARTRMVRGLLVILRACTRNRAMCSTAGLLGVLLRSAENIFAQDVGSIEPMKWDGTPLCYCIQHLAGHSLSVSDLHRWLQVITKTLTTIWAPRLMLALEKAVSGKESRGPACTFEFDGESSGLLGPGESRWPFTNGYAFSTWIYIESFADTLNAATAAAAIAAAAAAKSGKSSAMSAAAAASALAGEGTAHMPRLFSFLSADNQGIEAYFHAQFLVVECVSGKGKKASLHFTHAFKPQCWYFIGLEHVCRQGLIGKAESELKLYIDGSLYESRPFEFPRISKPLAFCCIGTNPPPTMAGLQRRRRQCPLFAEMGPVYIFKEPIGPERMARMASRGGDMLPSFGNGAGLPWLATNDHVQKMAEESSLLDAEIGGCIHLLYHPCLLSGRFCPDSSPSGAAGIIRRPAEVLGHVHVAMRMRPVEALWALAYGGPMSLLPLAVSNVCKDNLELEQGSLPLSLATAALAAPIFRIISVAIHHPGNSEELCRMSGPEILSRILNYLLQNLSYLCSGKHDGVGDEELVAAVVSLCQSQKHNHALKVQLFSTLLLDIKIWSLCSYGLQKKLLSSLADMVFTESSVMRDANAMQMLFDGCRRCYWTIREKDSLDAFSLNDAMRPMGEVNALVDELLVVIELLIGASPPSLAADDVRCLLGFMVDCPQPNQVARVLHLIYRLVVQPNTTRAQTFAQAFMGSGGIETLLVLLQREAKAGDHHIPETSTKTEESLAVERSEPELDTCVPEGSQDEGSLKEKDQISQKRDFHGISGLVASSSLKVERVSSVSENAFMKNLGGISLSISADNARNNVYNVDNDDGIVVGIIGLLGALVAYGHLKFGSRVSSEMTSNLFGGALNDAAGSMFEDKVSILLFALQKAFQAAPNRLMTSNVYTALLGASINASSPEDGLNFYDSGHRFEHLQLLLVLLRSLPYASRSFQSRALQDLLFLACSHPENRNSLTKMEEWPEWILEVLISNYEMDARKKSDSASLGDIEDFIHSFLIIMLEHSMRQKDGWKDIEATIHCAEWLSIVGGSSTGDQRIRREESLPIFKRRLLGGLMDFAARELQAQTQVIAAVAAGVAAEGLSPEDAKAETENAAQLSVFLVENAIVILMLVEDHLRLQSKLSCASCKVDGNKSPLSFASAPNSQSSSAASISRESTEAVDDSRSGNSGGLALDVLASMADANGQISATVMERLTAAAAAEPFDSVSSAFVSYGSCAMDLAEGWKYRSRLWYGVGLPSKPIDIGGGGFGWESWNAALQKDANGNWIELPLVKKSVSMLQALLLDDSGLGGGLGIGGGSGTGMGGMAALYQLLDSDQPFLCMLRMVLLSMREEDNGEDNMIMRNVGVEDGMSEGLYRGNIISLDNSGRMAARKPRSALLWSVLSPVLNMPISDSKRQRVLVASCVLYSEVWHAVGRDRKPLRKQYLEAIVPPFVAVLRRWRPLLAGIHELATADGLNPLNVDDRALAADALPLEAALAMISPSWAAAFASPPAAMALAMIAAGASGGEIPAPTATQLKRDSSILERKTTKLQHFSSFHKPLDMPNNSPSLPKDKAAAKAAALAAARDLERNAKIGSGRGLSAVAMATSAQRRHDSDVERVKRWNDSEAMAVAWLECLQPVDTKSVYGKDFNALSYKFIAALVASFALARNIQRSEIDRRAQVDLVARHRLFTGIRAWRKLIHCLLDTSCLFGPLVDQIPSKVFWKLDFMESSSRMRPFLRRNYTGTDHFGAAADFEEQNDVKKIQEDVISSSNTPILAAEAISTVFVNEDDEHPETDNVDSRGYVNNQSEEGQQRLSGITEQTLEKSIEPKDTKLASEQNLVQSSTIVAPGYVPSELDERILFELPSSMVRPLRVIRGTFQVTSKKINFVVDKTECNISMDGSEDNSEAKNDEKDRSWLMTSLHQMYSRRYLLRRSALELFMVDRSNFFFDFRSSEGRRNAYRAIVQARPPHLNNIYLATQRPEQLLKRTQLMERWARWEISNFEYLMQLNTLAGRSYNDITQYPVFPWILSDYSSKSLDLSDPSAFRDLSKPVGALNPERLKKFQERYTSFDDPVIPKFHYGSHYSSAGTVLYYLVRVEPFTTLSIQLQGGKFDHADRMFSDVGATWNGVLEDMSDVKELVPELFYLPEMLTNENSIDFGTTQLGGKLDSVKLPSWAQSSVDFIHKHRMALESEHVSAHLHEWIDLIFGYKQRGKEAISANNMFFYITYEGTVDIDKISDPVQQRATQDQIAYFGQTPSQLLTAPHMKKIPLSEVLHLQTIFRNPREVKSYAVPSPDRCNLPAAAIHASSDSVIIVDTDAPAAHIAQHKWQPNTPDGQGAPFLFQHGKAMTSSAGGALRRMFRGPAAAGSGSVDWHFPQALAFSSSGIRNSSIVSITCDKEIITGGHADNSIKLLSSDGAKTIEMAFGHSAPVTCLALSPDSNYLVTGSRDSTVILWRIHRAFTSRPSSTSEPTAGTGTPTSTSSGTLANTLADKSRKHRIEGPIYVLRGHQREILCCCVSSDLGVVVSCSHSSDVLLHSIRRGRLMRRFAGVEADAVCLSSEGVILTWNQSQHTLSTFTLNGVLVARAQLPSLGGVSCMEISVDGENALIGMNSSLGNNGMSNSNQDLSLKKPVADNLDLESEETNKSNKLDIPSPSICFLNLHTLKVFHVLELGEGQDITAFALNEDNTNLLVSTADKQLIIFTDPALSLKVVDQMLKLGWEGEGLSPLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAB9</accession>
    <name>A0A0D2SAB9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G095900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAB9"/>
    <dbReference type="STRING" id="29730.A0A0D2SAB9"/>
    <dbReference type="Gramene" id="KJB41229">
        <property type="protein sequence ID" value="KJB41229"/>
        <property type="gene ID" value="B456_007G095900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41232">
        <property type="protein sequence ID" value="KJB41232"/>
        <property type="gene ID" value="B456_007G095900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802655"/>
    <dbReference type="eggNOG" id="ENOG502QU6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWKATIN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000165">
        <property type="entry name" value="probable methyltransferase PMT13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF763">
        <property type="entry name" value="PECTIN METHYLTRANSFERASE QUA3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB41229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="597" mass="67060" checksum="14DD17F3E6A5944B" modified="2015-04-29" version="1">MGHLNLPASKRNPRQWKLLDIITAIFFGLVLLFFLLVFTPLGDSMAASGRQALLLSTSDPRQRHRLVSLVELGHHHKPIEACPANSVDHMPCEDPRRNSQLSREMNLYRERHCPLPDEMPLCLIPPPPGYKIPVQWPESLHKIWHSNMPHNKIADRKGHQGWMKEQGPHFIFPGGGTMFPDGAAPYIEKLGQYIPLTGGTLRTALDMGCGVASFGGSLLSEGILALSFAPRDSHKAQIQFALERGIPAFVLMLGTRRLPFPAFAFDFIHCSRCLIPFTAYNATYFIEVDRLLRPGGYLVISGPPVQWPKQDKEWADLQAVARALCYELIAVDGNTVIWKKPDGDSCLPNQNEFGLESCDESNDPSNAWYFKLRRCVTSTSSVNGEHPVGIIPKWPDRLTRAPSRALVVKNGIDLFRADTRRWTRRVAYYKNTLNLKLGSPAVRNVMDMNAFFGGFAAALVSDPVWVMNVVPARKPLTLGVIYDRGLIGVYHDWCEPFSTYPRTYDFIHVAGIESLIKLPGSSKSRCNLVDLMVEMDRMLRPEGTVVIRDSPEVIDKVARIAHAVRWTATINDKEPESHGREKILVATKTFWKLTSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDC3</accession>
    <name>A0A0D2SDC3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Ribophorin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_007G147600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the SWP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDC3"/>
    <dbReference type="STRING" id="29730.A0A0D2SDC3"/>
    <dbReference type="Gramene" id="KJB42299">
        <property type="protein sequence ID" value="KJB42299"/>
        <property type="gene ID" value="B456_007G147600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2447">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055375">
        <property type="entry name" value="Ribophorin_II_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055374">
        <property type="entry name" value="Ribophorin_II_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055373">
        <property type="entry name" value="Ribophorin_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008814">
        <property type="entry name" value="Swp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12640">
        <property type="entry name" value="RIBOPHORIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05817">
        <property type="entry name" value="Ribophorin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23861">
        <property type="entry name" value="Ribophorin_II_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23860">
        <property type="entry name" value="Ribophorin_II_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019610713" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2" evidence="10">
        <location>
            <begin position="29"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="637"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II N-terminal" evidence="11">
        <location>
            <begin position="35"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II second" evidence="13">
        <location>
            <begin position="319"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II third" evidence="12">
        <location>
            <begin position="433"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="14">
        <location>
            <begin position="590"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF23860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB42299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="698" mass="75742" checksum="B307AAEA8BC6C751" modified="2015-04-29" version="1">MPTNLNFEMARSLVGFTVLLLFLSICESTSFFQPISDSHRSAAVELFSPDHGSFKSLEETYEALRTFDVLGIEKKPDVTATACRLVSETVGSSSSTLKDLFYALKANSIVKCKINDKAYQGIITRLNAAVDGASSLPDFYYSVGGLLLVKGSKGDVHLADADGIFRSVKAFRQSDGRWRFSSNSPESSAFAAGIALETLAGVVSLASPELDQSLISTLNSDISKLFDSIEKYDDGALYFDDKLVDGHDHQGPLATTSSVVRGLTAFAAVTDERLNIPSNKIFGLANFFLGIGVPGDAKDLFNQIDSLACLESNRVSIPLILSLPSTVLSVTKEDSLQVNVNTVLGSNAPPLTVKLVGVFTSGSKAASLVESQELVFDDGTGMYNLNNLPKSIDVGSYTFVFEIVLHEPEHEKIYVTGGQKKVPIFASGLIKIENAEIAVLDSDLGSIETQKKLDLAGQNAVSLSANHLQKLRVSFKLTTPHGLAFKPHQALLKLRHESKVEHIFVVGNSGKQFEIVLNFLGLVEKFFYLSGRYDIELAVGDAVMENSLLRAIGHIELDLPEPPEKATRPPPQPVDPYSRYGPKAEITHIFRAPEKRPPKELSLAFLGLTFLPLLGFLIGLLRLGVNLKNFPSNTVPATFATLFHVSIGAVLSLYVLFWLKLDIFQTLKLLGFLGVILVLVGHRVLSYLAATSAKLKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDQ7</accession>
    <name>A0A0D2SDQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G350900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KJB61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_009G350900"/>
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    <dbReference type="eggNOG" id="KOG2507">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="WSPPGME"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
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        <property type="component" value="Chromosome 9"/>
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        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Ubiquitin-like_dom"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47770">
        <property type="entry name" value="PLANT UBX DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47770:SF1">
        <property type="entry name" value="PLANT UBX DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
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        <location>
            <begin position="308"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="3">
        <location>
            <begin position="310"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="509"/>
            <end position="523"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB61308.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="56638" checksum="E8306165F487A6B0" modified="2015-04-29" version="1">MERSESFSSLTFKGSIPEAILEAKIQKKLFVVYISGEDSESKNMEDSTWTDLKLKESLSKYCVLLHICGGSTDAANFSAIYPQKSVPCITAIGYNGVQVWQSEGSISAEVLASSLEKAWLSLHIQETTAAVLSAALASKKYESSSSGSSTVSQSEQGSSSSASVPSTTMANVVQTLESNPSVMSVVMEENRDCEQTVKEKNPELVENGSSESFSTDNLANIVDEQCDITNEEMRTVVSSVTSSLAVHASSHPEDDCLIPVKGTDHQPSCPAGSMPVSAAEAEKDMQHVKDKVDGALENTTTANIPTDVHLNIRLPDSSSLQEKFPVTYTLSMIKDYVDRNQSNGMGSYDLAIPYPRRLFGDQDLIKSLLDLGLFNRQALIVVPRRRTAGFQGQRPSDDNRNLTPIEDSAGSSGGYFSYIKSFLSYVNPFAYLGGGASSSTTGQESQSSIWEYSPNPTVQNNLGGRNRSTSTASDGGRNRRPVTTQHGSNIHTLKRDEDDDSFTDRNPFWNGNSTQYGGSSDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKG3</accession>
    <name>A0A0D2SKG3_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G268000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_007G268000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB44714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="107" mass="12716" checksum="DD019834BA6D0903" modified="2015-04-29" version="1">MKDLYFPKSFNLLLLLSTVVSFLSILISWTFPLHCSTDDIRNRPNQLLCWYGLLILKPKSPLPHLEQSNLKQILHVADRKLHQRRLTHSFFFLQFSDHHFLPNYQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLR6</accession>
    <name>A0A0D2SLR6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Senescence-specific cysteine protease SAG39-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_N010800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB204132">
        <property type="protein sequence ID" value="KJB84212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2SLR6"/>
    <dbReference type="MEROPS" id="C01.104"/>
    <dbReference type="Gramene" id="KJB84212">
        <property type="protein sequence ID" value="KJB84212"/>
        <property type="gene ID" value="B456_N010800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784778"/>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRGKNFC"/>
    <dbReference type="OrthoDB" id="10253408at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000023">
        <property type="entry name" value="Senescence-specific cysteine protease SAG39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018761043" description="Senescence-specific cysteine protease SAG39-like" evidence="8">
        <location>
            <begin position="27"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="10">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="9">
        <location>
            <begin position="125"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB84212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37461" checksum="B64EA9FBC0F8BD99" modified="2015-04-29" version="1">MASKNQLHHHFTCLALLIFILGICEATSRAALEDASMYERHQQWMVQFGRVYMDTNERQKRFQIFKQNVARIDSFNAANNKPYKLGVNQFADLTNQEFTASRNGFKGHMCSNTATTFKYENATALPSTVDWRKKGAVTPIKDQGQCGCCWAFSAVAAMEGVTKLTTGKLISLSEQELVDCDTKGEDQGCEGGLMDDAFQFIEKNKGLTTESIYPYKGVDGTCNTNEEANHAAKINGFEDVPANSEDALQKAVANQPVSVAIDAGGFDFQFYSGGVFTGSCGTDLDHGVTAVGYGEDGGTKYWLVKNSWGSSWGEEGYIRMQRDVDAKEGLCGIAMQASYPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNY1</accession>
    <name>A0A0D2SNY1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G334500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the purine permeases (TC 2.A.7.14) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNY1"/>
    <dbReference type="STRING" id="29730.A0A0D2SNY1"/>
    <dbReference type="Gramene" id="KJB45869">
        <property type="protein sequence ID" value="KJB45869"/>
        <property type="gene ID" value="B456_007G334500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRUH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTIDNYL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015211">
        <property type="term" value="F:purine nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030182">
        <property type="entry name" value="PUP_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376">
        <property type="entry name" value="OS09G0467300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376:SF101">
        <property type="entry name" value="PURINE PERMEASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16913">
        <property type="entry name" value="PUNUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB45869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="336" mass="37264" checksum="FFA5AAF4FFC6A397" modified="2015-04-29" version="1">MSSHAIAEPQTPHPEESTTTTTGQPPIFSPDNRWKPWLLIALNILFLLAGQSAAVLLTKFYFNNGGKSKWMASLMQTAAIDNFMYTVGVKPLSISTYSLLCASQLVFNAIFLVVINCEKLGILTLNLIIFITVSASMVAIHPDSSETKRDEKNPVRKNEHSIGFISIVGASAGYALLLSLTQFSFDKILKKDTFSVVFEMQIYTSLVSSFVCLLGLFLSLEFMDLKSEMEKFDEGKVIYVVSLIGIALAWQICTVGVVGLIYLVSSLFSNVVSMLSLPFVPVIGVLLYKEKMDASKVLAMLFTLWGFASYIYQQYLDDKKSKKKESQEIEASKSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNZ9</accession>
    <name>A0A0D2SNZ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G212600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNZ9"/>
    <dbReference type="Gramene" id="KJB43706">
        <property type="protein sequence ID" value="KJB43706"/>
        <property type="gene ID" value="B456_007G212600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYTNCGI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001093">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At2g34400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000343">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g58590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF544">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="173"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="375"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="476"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="577"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="675"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="776"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="811"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB43706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="107052" checksum="AE71F4B1228B5001" modified="2015-04-29" version="1">MVLKLPCGSFSSFMHLLKHCQSIQDLKPLKSLLIVQGLIRNNLLLGHFLKSCFYLGAPNLALSTFYKIQNPNLFCQNLMLKGLSSYGLYGDLLSVYTKCRVLNCPSDDFTFPFVIKACSALGASGIGQQIHCVVLRKGYERNVVIMTSFIDFYARNVDIGIARKLFDRISDPDLVSWNALLSGYCFNGLDKEALGVFGEIQGMNIKPNVSTLASIIPACTRLGYFYFGKSLHGLAVKCGYFFNDFLVPAFISMYKSEVDLSSARKLFYFAVERNVSVWNALINSYTQNERFFEGFEMFREMLRNDVQPNSVTFVSTVPFCENYFDISYGGSLHCCVIKHGFGSQVSVLTALMSTYAKLGEISSSEMLFDQIPNKTQLSWNVLISGYVNNGLPDESLVAFRKMQLEGFSPDAISIVSILSACSNLGDILLGQSIHAFVVRRSFETNINVSNAVLAFYSDCPLLSTCFRLFKRMATKNTVSWNTLISGYVHSGQKDKANVILHQMQKEGGKLDSVTLLSILSSYSESENFRKGTILHGYAIKTGWDSDVSLTNALISMYCNCEELDAGSLLFDAMPERSVVSWNSLMTGFRHYNLSNDVLVLFAQMVKENQRPNQVSILNLLPMCSMLSQGKSIHAFALRTGMIEETTVLTSLIFMYARFGKIKLSLLVFQTGKRCDISLWNAIMSVHVDTKNAKQAVAVFCEMLQISLEPDNITVLSLISSCVLLNSLNLADSVMAYIICKGFDKDVVVSNALIDLYARCGSIVVARLLFDYLFEKDAVSWSVMINGYRLHGDAEGALKLFSRMRLSGVSHDAITYLSLLSVCSHAGLVEEGQRVFNCMVEDGLSPRTEHYACMVDLLARAGHLHEAYNIVNRQPFKPSLGMLESLLGACKMYGNIEIGQRIFQMLFEMYPQNSESYVMLHNIYAAAGKWEDANTVRSIMEGRLLRKLPGFSLVGDNFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQ09</accession>
    <name>A0A0D2SQ09_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G354700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB46259"/>
        <property type="gene ID" value="B456_007G354700"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31549">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF247)-RELATED-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB46259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="372" mass="43305" checksum="4434134FD3BC86B4" modified="2015-04-29" version="1">MSSTEEGGGAVGAVSTDQTITNNNDFVSICIDLLRWKGELANLESLVKASNGTCNPLIRKVPSTLGRHEDFTHFVKKIGVDKHTLYNNMKTEWLEKCFDPKELEKYSNHNEKLAWMFFVDGCAIFQAVYMRYNLGHAIIRFINGTVKDPQSHQHFGVAGKTVFLTIFVDNKEPIHLLHLLRVRLLFKKEKPWHSRFCISFTNRRNHTRIKPHHSHPFRNVKELKNAGIWLEASETSCLTDISFNHYFFVGKLRLPPLTVDDSTMNLIAYEMCPDFYNNFTVTSYMGFLDSLIDEAEDWLIKKMNMDLVPSLMIYRHVKLQIHDHHNNMWIRYPAQVYRTFFRTRWTFFAFVGAIGALFIGALQAYYTIHQPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSN2</accession>
    <name>A0A0D2SSN2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G285200</name>
        <name evidence="4" type="ORF">Gorai_019701</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSN2"/>
    <dbReference type="STRING" id="29730.A0A0D2SSN2"/>
    <dbReference type="Gramene" id="KJB45016">
        <property type="protein sequence ID" value="KJB45016"/>
        <property type="gene ID" value="B456_007G285200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3KI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SLMTEIM"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574:SF12">
        <property type="entry name" value="CALCIUM-BINDING EF HAND FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="130" mass="14716" checksum="FEF4AD71FE703F1E" modified="2015-04-29" version="1">MSVAVLDSKTVTRFVEAKEAFKKCVEKYFKMVDSNGNGVICRRKLREGLDLLFTVEHESTVSKEDIDNFHSMIFDKFDEDRNGKLDLYEFAALVKEIMMAMARGMGSLPVIVALDQDSLLMMAVQHEIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Das S."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_011G1561001"/>
    </dbReference>
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            <begin position="20"/>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <location evidence="1">Cytoplasm</location>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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    </evidence>
    <sequence length="423" mass="47799" checksum="A7B9CD83B97AACE0" modified="2015-04-29" version="1">MKGVSLAPGDYIHFKSQVPLHKIPIGTKQWRYYDFGPKVVPPLICLPGIAGTADIYYKQIMSLSMKGYRVISVDIPQVWNHQEWIQSFEKFLDVINVHHIHLYGTSLGGFLAQLFAQHRPRRVKSLILSNAFLETRSFAAAMPWAPIVGWSPSFLLKRFVLTGIRDGPHEPFIADSVDFVVSQVETLSRDDLASRLTLTVDTATVEPLLLSDSFITIMDTNDYSAIPQQLKDQLSERYPGARRAYLKTGGDFPFLSRPDEVNLHLQVYLTYIVLLIHRANCFFQLVYRTWQLHLRQVGVEARPDLVQSIPKGGTGGSPSKESDKKKDPDDQPKDNGGNPESTSEESQLPPSSEIHSLDDQLLSDAKICSMGHKDAIILMQSQYTVVNRILQSACELFIFSLLPIYVESSYVTSNNVWKFRQLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T694</accession>
    <name>A0A0D2T694_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T694"/>
    <dbReference type="Gramene" id="KJB71203">
        <property type="protein sequence ID" value="KJB71203"/>
        <property type="gene ID" value="B456_011G1101002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB71204">
        <property type="protein sequence ID" value="KJB71204"/>
        <property type="gene ID" value="B456_011G1101002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB71203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="23" mass="2459" checksum="26D1DF1682E859C6" modified="2015-04-29" version="1" fragment="single">MTLLTSSLFPLSTPLPLLMASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T6M4</accession>
    <name>A0A0D2T6M4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G117000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T6M4"/>
    <dbReference type="SMR" id="A0A0D2T6M4"/>
    <dbReference type="STRING" id="29730.A0A0D2T6M4"/>
    <dbReference type="Gramene" id="KJB71328">
        <property type="protein sequence ID" value="KJB71328"/>
        <property type="gene ID" value="B456_011G117000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777023"/>
    <dbReference type="eggNOG" id="KOG0364">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000034">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000037">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="528"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB71328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="557" mass="60400" checksum="85ECE44F12CAE147" modified="2015-04-29" version="1">MHAPVLVLKDSLKRESGTKVHHANIQASKAVADIIRTTLGPRSMLKMLLDASGGIVVTNDGNAILRELDLAHPAAKSMIELSRTQDEEVGDGTTSVIVLAGEMLHVAEAFIEKNYHPTVICRAYNKALEDAIAVLDKIAMSIDVKDRATMLGLVKSCIGTKFTSQFGDLIADLAIDATQTVGVDLGQGLREVDIKKYIKVEKVPGGQLEDSKVLKGVMINKDVVAPGKMKRKIVNPRIILLDCPLEYKKGENQTNAELVKEEDWEVLLKMEEEYIESLCLQILKFKPDLVVTEKGLSDLACHYLSKAGVSAIRRVRKTDNNRIAKASGAVIVNRPDELQESDVGTGAGLFEVKKIGDEFFAFIVDCKDPKACTVLLRGASKDLLNEVERNLQDAMSVARNIIKNPKLVPGGGATELTVSATLKQKSSSVEGIEKWPYEAAALAFEAIPRTLAQNCGVNVIRTMTALQGKHANGENAWIGIDGNTGAIADMKERKIWDAYNVKAQTFKTAIEAACMLLRIDDIVSGIKKKQAPGAGQGPTKPKVETEADADGEQILPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TLT6</accession>
    <name>A0A0D2TLT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stigma-specific STIG1-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G180500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TLT6"/>
    <dbReference type="Gramene" id="KJB57784">
        <property type="protein sequence ID" value="KJB57784"/>
        <property type="gene ID" value="B456_009G180500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1NG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEICCNG"/>
    <dbReference type="OrthoDB" id="5421723at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227:SF32">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252681" description="Stigma-specific STIG1-like protein 1" evidence="3">
        <location>
            <begin position="19"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB57784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14658" checksum="B69DD54D89DA757B" modified="2015-04-29" version="1">MKFLKLFFMLAMVMALEAITLSTSISENSDHRRLADSQMPTSFGGAGGFRPFFTCDKRPEICSIKGQFCCNRRCVDLKTDQYNCGRCGRTCNYSKICCEGKCVSPLSNEKHCGGCNNNCGKGSSCLYGMCSYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TT93</accession>
    <name>A0A0D2TT93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G019400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TT93"/>
    <dbReference type="STRING" id="29730.A0A0D2TT93"/>
    <dbReference type="Gramene" id="KJB78793">
        <property type="protein sequence ID" value="KJB78793"/>
        <property type="gene ID" value="B456_013G019400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782678"/>
    <dbReference type="eggNOG" id="KOG2975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="21"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB78793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="286" mass="31324" checksum="5054BB9DE7CCD2D6" modified="2015-04-29" version="1">MAAGDHTVLQLSTPSTANLSAKVHPLVIFNICDCYVRRPDQAERVIGTLLGSVLPDGTVDIRNSYAVPHTESAEQVALDIEYHHNMLVSHQKVNPKEVIVGWYSTGLGVTGGSALIHDFYSREVPNPIHLTVDTGFRNGEGTIKAYVSVNLALGDRQLAAQFQEIPLDLRMVEAERLGFDILKTTAVDKLPNDLEGMEVTMQRLLALIDDVYKYVDDVVEGRVAADNSIGRFISDTVASLPKLSPSVFDKLVNDSLQDQLLLLYLSSITRTQLGLAEKLNTAAQIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TVC4</accession>
    <name>A0A0D2TVC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_009G253700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TVC4"/>
    <dbReference type="STRING" id="29730.A0A0D2TVC4"/>
    <dbReference type="Gramene" id="KJB59416">
        <property type="protein sequence ID" value="KJB59416"/>
        <property type="gene ID" value="B456_009G253700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769822"/>
    <dbReference type="eggNOG" id="KOG4282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AKTDNGD"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12203">
        <property type="entry name" value="GT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000061">
        <property type="entry name" value="Trihelix transcription factor GT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000092">
        <property type="entry name" value="Trihelix transcription factor GT-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654">
        <property type="entry name" value="FI21293P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21654:SF59">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR DF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="420"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="596" mass="65897" checksum="184F2CEE2825C76A" modified="2015-04-29" version="1">MLGGGGDTTASVLGSGGGGTDGNVTTTAGGGGAVTMGRSGGARDGGSSEGGGVAANNMFGSNGNNNNNSGDEDRVRVDEGDRCFGGNRWPRQETLALLKIRSDMDVTFRDASVKGPLWEEVSRKLAELGYHRSAKKCKEKFENVFKYHKRTKDVRTGKSDGKTYRFSNQLLALETHPSFQSPPATAAVAAPTSPPQAQPQATMPAPSLPNVTVPSAAALPSLPQNIVPTNINPTPTLPSFPNVSADQMSNSTSSSTSSDLELEGRRKKKRKWKGFFERLMREVVHEQEEMQKKFLEALEKREQERMAREEAWRMQEMARINRERELLAKERSVAAAKDAALMSLLQKLSEQKNPGQPQSNPLQQPQPPVSVVAAAATPAAALSVPAPQPPPPLVPQQPMLNLEVASKSDNGDHSCTPSSSRWPKVEVQALIELRTRLDAKYHDNGPKGPLWEEISAAMKKLGYNRNAKRCKEKWENINKYFKKVKDNHKKRPEDSKTCPYFHQLDALYREKNKHDSSSTQFKPQNSVPLMVRPEQQWPPLPPSDPDHQHRRDPEDLESYQNHQDEDGNDEYEDEDEDERGEYEIVASKPVSMGTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2Y5</accession>
    <name>A0A0D2U2Y5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G412300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thaumatin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2Y5"/>
    <dbReference type="Gramene" id="KJB62331">
        <property type="protein sequence ID" value="KJB62331"/>
        <property type="gene ID" value="B456_009G412300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767831"/>
    <dbReference type="eggNOG" id="ENOG502QQ6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSQYCCT"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000002">
        <property type="entry name" value="Thaumatin-like protein 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017949">
        <property type="entry name" value="Thaumatin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00316">
        <property type="entry name" value="THAUMATIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252278" description="Thaumatin-like protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="31"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="92"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="149"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="25347" checksum="BBE9954D574CE858" modified="2015-04-29" version="1">MMKAQLIFAVSLAAIFFSGTKAATFTLSNNCPSTVWPGILTSSGPPLSTTGFELPSKPSSVLSVPATWSGRIWARTQCTNVNGKFQCQTGDCASGQVPCNGAGGIPPVTLSEFTLAPNNGKDFFDISLVDGFNLPVSIAPQSADGSGNCIPVSCTDNVNAVCPNELQVKGSDGGVIACNSACLAFNQSQYCCTGSFGTPQTCPPTNYSNFLKSQCPQAYSYAYDDKSALVSCTGGANYLITFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5M8</accession>
    <name>A0A0D2U5M8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_013G225800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5M8"/>
    <dbReference type="STRING" id="29730.A0A0D2U5M8"/>
    <dbReference type="Gramene" id="KJB83023">
        <property type="protein sequence ID" value="KJB83023"/>
        <property type="gene ID" value="B456_013G225800"/>
    </dbReference>
    <dbReference type="OMA" id="SMMMPEV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009518">
        <property type="entry name" value="PSII_PsbX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34455">
        <property type="entry name" value="OS07G0673550 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34455:SF1">
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    </evidence>
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    <accession>A0A0D2UCV6</accession>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Mansoor S."/>
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                <person name="Reddy U.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
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                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Vaslin M.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
            <begin position="358"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB57565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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        </source>
    </evidence>
    <sequence length="402" mass="44088" checksum="85C1FCD4E3035214" modified="2015-04-29" version="1">MAVSLLTRQVSDLCLGKPALKSLSISSTIGDALLALKRLGENFISIWNCDHHHYNLSAVDRGFKECQCVGKVCMVNIICFLCKEEHLSNPATALQTPLSVLIPKSPCLVRHLEPNASLLDAIDLIQEGAQNLVIPLESSSKTSSRKKLVQGTLSNISTLHNNNRQYCWLTQEDIIRYLLNSIGLFCPTAANPINSLDIIDTRNKMALHYDDPASSALPFISRSLEIQASVAIVDSDRKLVGEISPFTLNYCDEDVAAAIATLSAGDLLAYVDCGGPPEDLVQLVKKRLQERNLEQALELVEEYSSGASIPTSYSSSSSDDEFGMGRSARWMGYSARVVRRSEAIVCYPWSSLVAVMIQALSRRVSYVWVVDDDGTLAGIVSFAGMMKVFRERSRTMGEGCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UT18</accession>
    <name>A0A0D2UT18_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G123800</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UT18"/>
    <dbReference type="STRING" id="29730.A0A0D2UT18"/>
    <dbReference type="Gramene" id="KJB71441">
        <property type="protein sequence ID" value="KJB71441"/>
        <property type="gene ID" value="B456_011G123800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778313"/>
    <dbReference type="eggNOG" id="ENOG502S4K3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MCCDGDC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055283">
        <property type="entry name" value="TAXIMIN_1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33834:SF2">
        <property type="entry name" value="SIGNALING PEPTIDE TAXIMIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33834">
        <property type="entry name" value="SIGNALING PEPTIDE TAXIMIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="76" mass="8305" checksum="FB899E19E403E6D2" modified="2015-04-29" version="1">MCCDGDCRPLGFLLGLPFAFLSLIISIVGVVVWIVGLLLTLICPCCLCVTVLVEIALELVKAPIHVMEWFTEQIPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UVU3</accession>
    <name>A0A0D2UVU3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G195000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M67C family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UVU3"/>
    <dbReference type="STRING" id="29730.A0A0D2UVU3"/>
    <dbReference type="MEROPS" id="M67.A06"/>
    <dbReference type="Gramene" id="KJB72756">
        <property type="protein sequence ID" value="KJB72756"/>
        <property type="gene ID" value="B456_011G195000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777932"/>
    <dbReference type="eggNOG" id="KOG2880">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.80:FF:000020">
        <property type="entry name" value="AMSH-like ubiquitin thioesterase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000024">
        <property type="entry name" value="AMSH-like ubiquitin thioesterase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF18">
        <property type="entry name" value="AMSH-LIKE UBIQUITIN THIOESTERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="14">
        <location>
            <begin position="333"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB72756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="507" mass="57248" checksum="0C28A11E2CF03E3F" modified="2015-04-29" version="1">MKLDVNAMARRVEVDNRIPLRYYYRIADSLLKQANIYREEKNIVDLYIILLRYSSLVSETIPFHRDYQVLLPKEKAVYRKRLLAVLDELESLKPEVQQRVEELNKAHTGARLVDLDDHEGPFHGSDKMSPSDWNPENRRLNMSLDIKQPANMEVQSSWKYNDNHNQIDRQFQKLSLNKPLPNKETLSRHSFLGPNGFHGQWLGPSAEIKVQYPSNKDLAPAENSSLNQAEQYGPLAVKDGEPGGVGSAMDSVLSLDDGRWLHPAEESCTSLTSEANQDLFQFVGMKQPSPPPVIAQVQPEFTPIHPSKVADPRPGPAKSSQDGLPNSSSFQHLHVPVQMMEDFLRLARANTEKNLETCGVLAGSLKNRVFHITALIIPKQESTSDSCSTLNEEEIFEVQDKLSLFPLGWIHTHPTQTCFMSSVDLHTHYSYQIMLPEAIAIVMAPTDTSSPHGIFHLSDPGGVSIIRNCQQRGFHPHEEPSDGTPIYEHCSHVFMNPKIKFDVVDLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V262</accession>
    <name>A0A0D2V262_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L34e superfamily protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G053800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V262"/>
    <dbReference type="STRING" id="29730.A0A0D2V262"/>
    <dbReference type="Gramene" id="KJB75731">
        <property type="protein sequence ID" value="KJB75731"/>
        <property type="gene ID" value="B456_012G053800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RM6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPTVKDG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996">
        <property type="entry name" value="OS05G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996:SF4">
        <property type="entry name" value="RIBOSOMAL PROTEIN L34E SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25564" checksum="11AE2D97B3E395AB" modified="2015-04-29" version="1">MVYFHRSISACNSADQASPMANSGNSSDLMMNPKSASSKGNFCKKQKVFNPPSCLKIPSCERSRSAAVDVVILIAVIAAFGILLFPTIKCISLKVIEFIEAAYDLVRDEMMISPMIYGSIGLGFSCSAIAAWILLLCTTRKCGNPHCKGLNKATEFDIQLETEECVKNLCPTVKDGVSKGLLQLLHNRHKELEAELKRLAPVNGRAVLVFRAKCGCSVGRLEVPGLKKQRKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4W5</accession>
    <name>A0A0D2V4W5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRONE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G108700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V4W5"/>
    <dbReference type="STRING" id="29730.A0A0D2V4W5"/>
    <dbReference type="Gramene" id="KJB76824">
        <property type="protein sequence ID" value="KJB76824"/>
        <property type="gene ID" value="B456_012G108700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779660"/>
    <dbReference type="eggNOG" id="ENOG502QPIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1053009at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000004">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000001">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1310:FF:000003">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2010">
        <property type="entry name" value="PRONE domain, subdomain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005512">
        <property type="entry name" value="PRONE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038937">
        <property type="entry name" value="RopGEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101:SF14">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03759">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51334">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRONE" evidence="5">
        <location>
            <begin position="189"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="650"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB76824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="696" mass="78345" checksum="D482573061842E20" modified="2015-04-29" version="1">MDGPFIHREQIGSTQQQDYQFKLCLPVPKLKASSFWVPKSVKSLCYRAIEPNVCCLERLDYGGTIVNNSAVRDSPGVLEEKRADMEGLVEKKERIEEKIKSFGENGVQMGTFAVLLEDKGRESSSSSDLFTSETTVHEEEHSHSSSEEDLYSPPSLDWHGHEIAETEDSSICSSFSEDRKKPPMDDRKLEKQGSTVSEIELMKERFAKLLLAEDMSGCGNGVCTALAISNAITNLCATLFGQIWRLEPVPLEKKAKWQREMEWFLSVSDHIVELIPSWQTFPDGSKLEVMTCRPRSDLYVNLPALRKLDNMLLEILDSFVDTEFWYVDHGILAQEAAGSTPFRKALQRQEEKWWLPVPRVPAGGLDENSRKQLQHRRDCANQILKAAMAINNITLADMEVPESYFESLPKNGRASLGDLIYRYVSSDLFTPECLLDCLDLSSEHQAIDIANRVEASIYLWRRKTNPKPVNNTSRSSSKSSWDMVKDLMVDAEKREILADRAESLLLCLKQRYPDLPQTTLDMSKIQYNKDIGKSILESYSRVLESLAFNIVARIDDLLYVNDLTKHSDQFSSPTRVGVISWKSLSIPYSVPFSSTPYRTAFTTPNFSPAHLVSPVKGESSPLFSSNKIPHHGMGVKKVLLTDYLGIDLRDKEHSSPNEGTESGSTSSIARESRVSFEGLKEAVSLPKPEPAPENEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V6G7</accession>
    <name>A0A0D2V6G7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G172800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB78016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V6G7"/>
    <dbReference type="STRING" id="29730.A0A0D2V6G7"/>
    <dbReference type="Gramene" id="KJB78016">
        <property type="protein sequence ID" value="KJB78016"/>
        <property type="gene ID" value="B456_012G172800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THGTFPK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF45">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="170" mass="18847" checksum="6AB006B51B26E624" modified="2015-04-29" version="1">MAAITAQLASFKFFSSLLNDRKCSRFCCQIKSFENQHSNWSVEFLSGKESIVCNKVRIGDQRIVRIKEGDATGRHVVIVDDLVQSGGTLIECQKVLAANGATKISAYVTHGTFPKSSWQRFEHDNGGQTEKGLTYFWITDSCPHTVKEVKCKRPFEILSLSGSIAAALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V887</accession>
    <name>A0A0D2V887_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi to ER traffic protein 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G025000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V887"/>
    <dbReference type="STRING" id="29730.A0A0D2V887"/>
    <dbReference type="Gramene" id="KJB78901">
        <property type="protein sequence ID" value="KJB78901"/>
        <property type="gene ID" value="B456_013G025000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3024">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000387">
        <property type="entry name" value="Golgi to ER traffic protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41988" checksum="562D831B90007D29" modified="2015-04-29" version="1">MSREKLRRAALPPVQENIDKLEKAINEGNFYGAQQMYKSISARYVSAERYSEALDLLESGACLQLKHGQVTCGAELAFLFVDTLVKGKIPYNEDILDRVRKIYEVFPKVPLPSNMSDDEDVREFTEALGAAKTRLEGCSSFIRAAIKWSAEFGASRNGDPQLHAMLAEYIYSESTELNMAKVSYHFVRGNNPKKFASTLVNFMSKCYPDEDDIAIARAVLMYLSMGNLRDANCLMNELKRQVESQELDFPESDLVQFITFLLLTLERDALPLFNMLRVNYKSSIDREPAFNELLDEIAEKFYGVQRRNPLQGMFGDLFKVIIDISVHLLFSIIRNSWHKKTIIYRIISENQKHSLGHLVQCNLFAMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V8V6</accession>
    <name>A0A0D2V8V6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G050800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V8V6"/>
    <dbReference type="Gramene" id="KJB79221">
        <property type="protein sequence ID" value="KJB79221"/>
        <property type="gene ID" value="B456_013G050800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502T2I2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="157" mass="17814" checksum="242408058AF78AE9" modified="2015-04-29" version="1">MILQSHVHLVLRLLQCFATLLSQGREIFVFCWPFLFPSFLSLNWLLLINCFIPLFSQGSAELDFLATIIPGQGREIFVFCWPFLFPSFLSLNWLLLINCFIPLFSQGSAELDFLATIIPVHNIDNQKEKSAGAFRESNSGPLAPKARIIPLDQMPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF94</accession>
    <name>A0A0D2VF94_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
            <ecNumber evidence="7">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G177400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Is involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GST superfamily. Tau family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="7"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF94"/>
    <dbReference type="STRING" id="29730.A0A0D2VF94"/>
    <dbReference type="Gramene" id="KJB82121">
        <property type="protein sequence ID" value="KJB82121"/>
        <property type="gene ID" value="B456_013G177400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYIDMVW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000018">
        <property type="entry name" value="Glutathione S-transferase U20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF781">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE U19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0216">Detoxification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB82121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="215" mass="24893" checksum="57E2E08C05194B2D" modified="2015-04-29" version="1">MAEEVVLLDFWPSPFGMRSRIALAEKGIKYEHKEEDLRNKSALLLQMNPVHKKIPVLIHNGKPVCESLIQVQYIDEVWHDKAPLLPSDPYQKATARFWADYIYELGGRVWKTKGEEQATAKKELIETLKLLEKELGDKPYFGGESLGYVDVAFIPFYSWFYALEKCGNFSIEAECPKLIAWAKRCMQKESVAKSLPDQQKVYDFILEMKKHFGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH84</accession>
    <name>A0A0D2VH84_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G185000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH84"/>
    <dbReference type="STRING" id="29730.A0A0D2VH84"/>
    <dbReference type="Gramene" id="KJB82248">
        <property type="protein sequence ID" value="KJB82248"/>
        <property type="gene ID" value="B456_013G185000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82249">
        <property type="protein sequence ID" value="KJB82249"/>
        <property type="gene ID" value="B456_013G185000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783356"/>
    <dbReference type="eggNOG" id="ENOG502SC9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RADCLWD"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12988" checksum="6E9097885DFFE4DA" modified="2015-04-29" version="1">MATPSKNMKAFYKQKKKNTTGGITKSKSSKSTKPAATDIAQLPHGVSLDFEDADIEEEERALREFDMNMAYGPCIGITRLGRWERAQRLGLNPPKEIEKLVKSGKVKLQSLFDGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHR1</accession>
    <name>A0A0D2VHR1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">S-acyltransferase</fullName>
            <ecNumber evidence="15">2.3.1.225</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Palmitoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_013G236500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="15"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHR1"/>
    <dbReference type="SMR" id="A0A0D2VHR1"/>
    <dbReference type="STRING" id="29730.A0A0D2VHR1"/>
    <dbReference type="Gramene" id="KJB83231">
        <property type="protein sequence ID" value="KJB83231"/>
        <property type="gene ID" value="B456_013G236500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783084"/>
    <dbReference type="eggNOG" id="KOG0509">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINAHHG"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000300">
        <property type="entry name" value="S-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF17">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="428"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="110"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="177"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="16">
        <location>
            <begin position="383"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB83231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="609" mass="67309" checksum="7A517664D771E275" modified="2015-04-29" version="1">MSSEIKVVEKVQPLKQLGGVVTNGNGNGQGYNGVVGDYAYYASLRNDVYCAAAYGDLGRLRMLVEHLGFSLKERDALGYYALQWAALNNRTDITQYIIEHGGDVNAKDQSGQTALHWSAVRGLIQVAEVLLQGGAWVDAADVNGYRITHVATQYGQTAFLYYVVSKWNADPDVPDNEGRSPLHWAAYKGFMDCIRLLLYLDANRGCQDREGCTPLHWAAIKGNLEACTLLLQGSQEGLAVTDNSGLTPAQLASEKNHRKIAFLLGNTRRLHEYRSNRNSCLGKLPKLGLAPVLCCVIVVHLTTYIHSVIMASNLPKLTAGFGILAWLGVFLSSAGLIWFYRCSSKDPGYIKMNVSDHQNLKEDEPLLKIEANHPALLAGNWSQLCTTCKIIKPLRAKHCSTCDRCVEQFDHHCPWVSNCVGKKNKWDFFLFIVLEVMAMVITGVVAMTRILTDPMAPAGFSPMFSHASTHHIGALTFLIMDIFYFFGASAFVVSQATQISRNITTNEMANIMRYSYLRGADGQLRNPYDHGCWKNCSDFVINGYNEDVPIAEDSANSEETGMIQIPRDSNLQNSNSHAPTDRNGHIAVHVNSSNINAHHGPVHSLVQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPC5</accession>
    <name>A0A0D2VPC5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G199100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPC5"/>
    <dbReference type="STRING" id="29730.A0A0D2VPC5"/>
    <dbReference type="Gramene" id="KJB72815">
        <property type="protein sequence ID" value="KJB72815"/>
        <property type="gene ID" value="B456_011G199100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777130"/>
    <dbReference type="eggNOG" id="KOG1238">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SDHMIFF"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051871">
        <property type="entry name" value="GMC_Oxidoreductase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968">
        <property type="entry name" value="OSJNBA0019K04.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968:SF20">
        <property type="entry name" value="PROTEIN HOTHEAD-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266076" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="28"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="513"/>
            <end position="514"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="553"/>
            <end position="554"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="450"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB72815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="574" mass="63203" checksum="432BCC29D35FF627" modified="2015-04-29" version="1">MGLKYSWRFLALVFMVVIANFHGLNYAEKGIKFEEKQIVTFSHSDMPAPKYSFIQEATSAPEVSFYDYIVIGGGTAGCPLAATLSARDAKVLVLERGGSPYTNTTKIRMENVISTLTDDSPNSISQSFISEDRVPGNRARVLGGGTVINLGFYSRAETLFLKEAGIDEALANESYEWVEKKIVYKPGAFQWQTAVRNGLLEVGVLPDNGFTYAHLNGTKTSGTIFDKNGNRHTAADLLEYANPTMIKVYLHAVVHKITFTIKDGQRPKADGVIFYDANGGRHIAYLKHESNNRSEIILSAGAIGSPQLLMLSGIGPTARLRSLGIKVVLDQPMVGREMADKPLNGLIIPYPTHIPLSLATVVGINKTSNYFESLNGFDLSALSGSGGAQPQTSNPSQEAMANSTRNQAFLVQTIFGPISKGYLELQNTNASDNPKLRFNYFQAAVDLRRCVSGMQTVINVVNSDSLSRFRFRNMTTQDLINMTVNRAGNLRRRNPNATTSLEQYCIDTVMTFWHYHGGCQIGKVVDKDYKVLGLDQLRVIDASTFSFSPGTNPQAAIMMLGRSMGRRILQSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VR82</accession>
    <name>A0A0D2VR82_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G2412001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VR82"/>
    <dbReference type="STRING" id="29730.A0A0D2VR82"/>
    <dbReference type="Gramene" id="KJB73625">
        <property type="protein sequence ID" value="KJB73625"/>
        <property type="gene ID" value="B456_011G2412001"/>
    </dbReference>
    <dbReference type="OMA" id="QPRECET"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16048" checksum="13CF7BCA08A3309A" modified="2015-04-29" version="1" fragment="single">MGKEKVHINIVVIGHVDSGKSTTTGHLIYKLGGIDKRVIERFEKEAAEMNKRSFKYAWVLDKLKAERERGITIDIALWKFETTKYYCTVIDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W3B1</accession>
    <name>A0A0D2W3B1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G069600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W3B1"/>
    <dbReference type="Gramene" id="KJB79660">
        <property type="protein sequence ID" value="KJB79660"/>
        <property type="gene ID" value="B456_013G069600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="129" mass="15521" checksum="97D080318ED02F9E" modified="2015-04-29" version="1">MLYCWFRFIRHLLSISRRFIRCRGHTSLPCMSIVSTVVAIVRERFVLHPLRMVFHTDLQYQRLSQIETHCQPSKLTYRPVFSIIINLDNPSNRFTNGLQNTLLIHATRKANPNHQRRREHLRCRERRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LUC4</accession>
    <name>A0A0D2LUC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G036700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LUC4"/>
    <dbReference type="STRING" id="29730.A0A0D2LUC4"/>
    <dbReference type="Gramene" id="KJB07672">
        <property type="protein sequence ID" value="KJB07672"/>
        <property type="gene ID" value="B456_001G036700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXWM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009788">
        <property type="term" value="P:negative regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001366">
        <property type="entry name" value="Zinc finger protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044246">
        <property type="entry name" value="ZFP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287">
        <property type="entry name" value="C2H2 AND C2HC ZINC FINGERS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47287:SF17">
        <property type="entry name" value="C2H2 AND C2HC ZINC FINGERS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB07672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="29717" checksum="5F8F8948F134FD3E" modified="2015-04-29" version="1">MESVRKEPSPSESTSCVISAPDAPSISDEQLKKPKPRLQLDLKLSTSDSDVPAFNFNQELNLIGSLNTPETPQPADSEQRVFSCNYCQRKFYSSQALGGHQNAHKRERTLAKRAQRIGVHAAFGGHPYFHHNHCSSLASFPLQGPHNRSLGIEVHSSMIHEPSRMISSSAGFGNVYGHPSWSRLPINQQPAIGKLSTENSHAISRPGSTSRASLGRFDNVMRSRMMGLGSSADDGQVIGNSWWSNGGGGGGSLNRKTELQERPSDIKFQILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M715</accession>
    <name>A0A0D2M715_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_002G052600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M715"/>
    <dbReference type="STRING" id="29730.A0A0D2M715"/>
    <dbReference type="Gramene" id="KJB13032">
        <property type="protein sequence ID" value="KJB13032"/>
        <property type="gene ID" value="B456_002G052600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWKSIEL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF46">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="754"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="58"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="801" mass="89378" checksum="B0A96560F2395536" modified="2015-04-29" version="1">MSPIASQFGKLTSLTHLNISESGFKGKIPLAISYLSKLLSLDLSDNHGLIFEGHVFENIVENLTQLRHLHLSNIDMSSELPDSVGNLRSLEILDLGGGNLKGPIPASLGNLTQLEHLDLSHNNFDGPIPCSVFNFTQLQFLDLSKNKLVGSFPSKVSGLSQLSILRLHHNFLSGRVPSWFFTLPSLVELMLNSNKLNGNFELTKLSELSKLEVLSLSDNALSSFTSASNSNYSLPCLVSLQLSSCNISEFPNFVRNLEGLNFLNLSYNRIHVIEADMFLKFKGLQVLDLSHNIHLSVGNNSEVDLVLPWLSDLCMSSCNITELSNFLTTQESLMFLDLSNNNIQGRITEQENNWGSNLVNLDLSNNLLTALEYYPWKSIELLDLGSNLIEGPLLAPPPSTMAFLISNNRLNGEIPSSICNPESSYLILYLDLSYNNLSGAISKCLGLRYHSNLDLQMNKFYGNIPDFWVERNYGLQILNLNNNDFDGSLPKSLANCLGLEVLNLANNKINDTFPHWLGDLPRLKVLVLRSNYFHGQIAHSANESHFSTLQILDLSHNRFSGFLPTTYFRNFKGMMNLASVPMEYIGADRSYYIYSLALTMKGVEFMLERVLTIFAAIDMSSNRFEGTIPETVGNLISLKVLNLSHNHLTGHIPSSLGNLAQLESLDLSCNKLVGEIPSELTDLNFLEVLNLSENQLVGLIPQGKQFNTFLNDSYVGNTELCGFPVSKSCGHSDPPSAIFEEEEFDSAFGLDWKFVMMGYGCGLVFGFSAGYIMMTIRKPKWLVWMIQQAGNRVLRRFKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MJ26</accession>
    <name>A0A0D2MJ26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ras-related protein Rab11A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_003G040900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MJ26"/>
    <dbReference type="STRING" id="29730.A0A0D2MJ26"/>
    <dbReference type="Gramene" id="KJB18227">
        <property type="protein sequence ID" value="KJB18227"/>
        <property type="gene ID" value="B456_003G040900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787806"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYECVER"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB18227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24644" checksum="B6651508750CB103" modified="2015-04-29" version="1">MANADPSQKVDYVFKVVLIGDSGVGKSQILARFARNDFSLDSKSTIGVEFQTRTLLIEHKSVKAQIWDTAGQERYRAVTSAYYRGAAGAMLVYDVTKRQTFNHIARWLEELRGHADKNIVIMLVGNKSDLEKQREVSTEDATEFAQKEGLFFLETSALAAKNVETAFLTVLTEIFNIVNKKNLVAGENQGNGNSNPTSLAGKKIIIPGPAQEIPAKRNMCCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ML26</accession>
    <name>A0A0D2ML26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late embryogenesis abundant protein LEA-2 subgroup domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G084900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ML26"/>
    <dbReference type="STRING" id="29730.A0A0D2ML26"/>
    <dbReference type="Gramene" id="KJB19097">
        <property type="protein sequence ID" value="KJB19097"/>
        <property type="gene ID" value="B456_003G084900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788271"/>
    <dbReference type="eggNOG" id="ENOG502S144">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VNIMNIM"/>
    <dbReference type="OrthoDB" id="1894389at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055301">
        <property type="entry name" value="Lea14-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31852">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein LEA-2 subgroup" evidence="3">
        <location>
            <begin position="98"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB19097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="213" mass="23706" checksum="796F7D0B6CA266A9" modified="2015-04-29" version="1">MQEDPQAKSLAPIEDHPRSDMEFGGIKPKAFQRDEKSSKCLVYILVIMVIQGSILLVFASYFLRARTPGFEIGSVAVRNLKYGNSSAPSFNFTLVTQVTVENTNFGDFRFDNSTGSIWCGSEVVGLMKIPKGRAQARASERMKVSIQVSSVRLSDANNLASNMSYGLLELKSYVKLSGKVNIMNIMKRRRNPEMNCFMKLNLTGNTIQGLKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MUK2</accession>
    <name>A0A0D2MUK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_004G065500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 17">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Membrane</location>
            <topology evidence="17">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUK2"/>
    <dbReference type="STRING" id="29730.A0A0D2MUK2"/>
    <dbReference type="Gramene" id="KJB22784">
        <property type="protein sequence ID" value="KJB22784"/>
        <property type="gene ID" value="B456_004G065500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22787">
        <property type="protein sequence ID" value="KJB22787"/>
        <property type="gene ID" value="B456_004G065500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22788">
        <property type="protein sequence ID" value="KJB22788"/>
        <property type="gene ID" value="B456_004G065500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790568"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYQRHAT"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF47">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="12 15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="76"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="181"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="281"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB22787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="378" mass="41276" checksum="D9E0860AEFEA3948" modified="2015-04-29" version="1">MDQIQHPTVMQKVAGQLLSSSISRDFQGYDGSFRRPSLYQGHFAYGNYSNAGMHYPIVPSTATAICVQAPAEKGFTSFAIDFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKTGRLSEPYKGIADCFKRTMKDEGVVSLWRGNTANVIRYFPTQALNFAFKDYFKRLFNFKKDRDGYWKWFAGNLASGGAAGASSLLFVYSLDYARTRLANDAKAAKKGGERQFNGLVDVYRKTLKSDGIAGLYRGFNISCVGIIVYRGLYFGMYDSLKPVLLTGDLQDSFFASFALGWLITNGAGLASYPIDTVRRRMMMTSGEAVKYKSSLDAFSQILKNEGAKSLFKGAGANILRAIAGAGVLAGYDKLQLIVFGKKYGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N4H1</accession>
    <name>A0A0D2N4H1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G271400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N4H1"/>
    <dbReference type="STRING" id="29730.A0A0D2N4H1"/>
    <dbReference type="Gramene" id="KJB27007">
        <property type="protein sequence ID" value="KJB27007"/>
        <property type="gene ID" value="B456_004G271400"/>
    </dbReference>
    <dbReference type="OMA" id="YINVGTE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB27007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="480" mass="55530" checksum="A775585910AC0778" modified="2015-04-29" version="1">MENTGTKEWSKRDEEEPETSTNKRCCSPPFENLSVDELAQQIQSKLDSLNNVSQHVKPDYCIFRIPGKFSDENLAPYRPRYTVIGPLVYYYYFSGHQEEEKQIYVASLNDFIELIEKYLSKIHGFYEKMYYRCWDDSVGRARQDKRAGTQSHSSLLIGMILVDAGFILELLLRAYSEGLRAENDLIFAKSGTIHDLKRDLMLLENQLPFFLLKKMYKRALKCNPHYPSFLHLTCHFFSHYYNQSISIDEVLSPNNPRSSEYRSNLEDPKHFTDLIRTFSATILHDSEAAAEGKVQQQQQGAYLYSAVLLREAGVKFKVSLNTCLFDIEFDENNGELKIPPLKVDESTESFYGNLMVWEQCYYPNDTFICDYIFLIGYLIKSAEDVSILVRKRILINQLGSPIEIVAMFNRLCKYINVGTENRYSSLFMKLNAYNAVPHHSWIVILKLEYFSTPWRGVATIAAIILLVLTMIQTICALISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8A9</accession>
    <name>A0A0D2N8A9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G056300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8A9"/>
    <dbReference type="STRING" id="29730.A0A0D2N8A9"/>
    <dbReference type="Gramene" id="KJB28572">
        <property type="protein sequence ID" value="KJB28572"/>
        <property type="gene ID" value="B456_005G056300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2938">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEHINVM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46692">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46692:SF1">
        <property type="entry name" value="NUCLEOSIDE HYDROLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="40"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="2">
        <location>
            <begin position="510"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB28572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="889" mass="100011" checksum="0C5F01E0447F8EC2" modified="2015-04-29" version="1" fragment="single">FFSEKLRMFWLRKFWIIILVLVVDVFGARVHAVPAKPRRILLDTDVDTDDFFALLYLLKLNRSEFELEGITINTNAWTNAGHAVNQIYDILYMMGRDDIAVGVGGEGGILEDGTILPNVGGYLPIIEQGMTTAGGCRYRQAIPVGLRGRLDFDTNYGIRKSFLPQGSRKYSPLKQPTAQQVMIEKTSAGPITVFVTGAHTNFAVFLMKNPHLKRNIEHINVMGGGVRSNNPTGCCPKHGTPHCHPRQCGDPGNLFTDYNTNPYAEFNIFGDPFAAYQVFHSGIPVTLVSLDATNTIPITEEFFKAFEQSQWTYEAQYCFKSLKMARDTWFDDRFYTSYFMWDSFTSGVAVSIMRNYGKNNGENEFAEMEYMNISVVTSNEPYGICDGSNPLFDGRHFPKFKLNKSGLHSGHVQMGLRDPFCFVENGEGKCKDGYTEEGTGPDSVRVLVATKAKPNHDLTSKLNREFFTNFLDVLNRPENTARFNLTTEFPHFRQAFYEPDFKNKTLGKPVVFDMDMSAGDFMALFYLLKVPVELLNLKAILVSPTGWANAAAIDIVYDLLHMMGRDDIPVGLGDVFAMSQSDQIFHLVGDCKYAKAIPHGSGGFLDSDTLYGLARDLPRSPRRYTAENSVKFGAPRDTDQPELRQPLALEIWTSILKTMDLGSKITVLTNGPLTSLAKIITRTNSTSFIQNVYIVGGHISRSSLDEGNVFTIPSNKYAELNLFLDPIAAKTVFKSGLNITLIPLGTQRKVSRFIETIKRLQLTRTPEARFVKSLLSRLYTLKQAHHRYRHTDIFFGEILGAILMAGDQRKLKPTMQEMPIKVIAEGIEAIDGQILIDEKHGKLVQILKNIDPMAYYDQFADRLGDEKRSAVLGSYDEQRKMWNTPPNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NHZ7</accession>
    <name>A0A0D2NHZ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_005G243800</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NHZ7"/>
    <dbReference type="STRING" id="29730.A0A0D2NHZ7"/>
    <dbReference type="Gramene" id="KJB32507">
        <property type="protein sequence ID" value="KJB32507"/>
        <property type="gene ID" value="B456_005G243800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795306"/>
    <dbReference type="eggNOG" id="ENOG502QR5S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTATCAY"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000433">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000561">
        <property type="entry name" value="Probable LRR receptor-like serine/threonine-protein kinase At2g16250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000448">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051716">
        <property type="entry name" value="Plant_RL_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053">
        <property type="entry name" value="LEUCINE RICH REPEAT FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48053:SF141">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248062" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="29"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="417"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="492"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="815"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="854" mass="94512" checksum="F9CA06B7D176C115" modified="2015-04-29" version="1">MVDQRNIGVALVLFYLLLLSLLFKPTVEQRLSSSIEFTALFELRSSLGLKSRDWPRKVDPCSSWNGIRCENGSVFEINISGFRRTTVGRQNPRFAVDSLVNFTRLVSFNASKFLLPGSIPDWFGRRLLTLQVLDLRSCNITGVIPSSIGNLSNLSILYLSDNRLTGAIPSSLGRLLSLSVLDLSNNLLTGSIPPGIGALSQLQILNLSSNSLRFSIPAQLGDLDSLVDLDLSSNSLSGLVPEDLSGLRNLQRMVLGNNGLTGLLPVNLFRSPSLLQVIVLRNNSFTGELPEVIWSISGLNLLDISQNNFTTELPNFASYDNATAAVLDISGNKFYGSLTTVLRRFSSMNLSENYFEGSVPDFVLGNASLGTNCLQNVSNQRTLTDCVSFYGERGLSFDNFGPPPPESGKSNSNRNRIILAAVLGGAGFIMLLTLFLLLVLRVRTRRRVSHRGIDVGQVCAETTPPSPGLAINFSSLGDLFTYQQLLQATGNFTEANLIKHGHSGDLFKGILESGLPVVIKRVDLQSIKKEVYLSELDFFNRFTHTRLVPLLGHCLEKENEKFLVYKYMPNGDLLSSLYRKINSETDGLQSLDWITRLKIAIGAAEGLSYLHHECTPPIVHRDVRASSILLDDKFEVRLGSLSKFCLQEDDGRQNGITRLLQLPRSSSERGSSDSSTALCAYDVYCFGMVLLGLVTGNLDMNASSETEMKEWLEQTLPYISIYDKELVTKILDPSLLVDEDLLEEVWAMAIMARSCLNLKPSRRPLMRYLLKALENPLRVVREDHSSSARLRRTSSRGSWNAALFGSWRRSSSDIAASTTRAEGGADHTSSRKHHSKEIFIFPEPPPQETERLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJF6</accession>
    <name>A0A0D2NJF6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G013800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJF6"/>
    <dbReference type="STRING" id="29730.A0A0D2NJF6"/>
    <dbReference type="Gramene" id="KJB33157">
        <property type="protein sequence ID" value="KJB33157"/>
        <property type="gene ID" value="B456_006G013800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DFAWRGL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="137" mass="15048" checksum="3C9605AB1CD82CB7" modified="2015-04-29" version="1">MASRLFATATEKIGQLALRRQVLALTDAAASRIHHLLQQRQRSFLRLGAKARGCNGLSYTLNYADEKGKFDELVEDKGVKILIDPKALMHVIGTKMDFVDDKLRSEFIFINPNSKGQCGCGESFMTTVGSTAKQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NXC4</accession>
    <name>A0A0D2NXC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chitin-binding type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G230700</name>
        <name evidence="10" type="ORF">Gorai_001653</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 19 family. Chitinase class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NXC4"/>
    <dbReference type="STRING" id="29730.A0A0D2NXC4"/>
    <dbReference type="Gramene" id="KJB37992">
        <property type="protein sequence ID" value="KJB37992"/>
        <property type="gene ID" value="B456_006G230700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800450"/>
    <dbReference type="eggNOG" id="KOG4742">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYCDETR"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00325">
        <property type="entry name" value="chitinase_GH19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.20.10:FF:000001">
        <property type="entry name" value="Endochitinase (Chitinase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.20.10">
        <property type="entry name" value="Endochitinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018371">
        <property type="entry name" value="Chitin-binding_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016283">
        <property type="entry name" value="Glyco_hydro_19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000726">
        <property type="entry name" value="Glyco_hydro_19_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595">
        <property type="entry name" value="CHITINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22595:SF119">
        <property type="entry name" value="ENDOCHITINASE EP3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00182">
        <property type="entry name" value="Glyco_hydro_19"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001060">
        <property type="entry name" value="Endochitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="Lysozyme-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00026">
        <property type="entry name" value="CHIT_BIND_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00773">
        <property type="entry name" value="CHITINASE_19_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00774">
        <property type="entry name" value="CHITINASE_19_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3 5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715536" description="Chitin-binding type-1 domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="8">
        <location>
            <begin position="24"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5 6">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5 6">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="5">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001060-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB37992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0588557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="267" mass="28606" checksum="FAC21CC968BF7236" modified="2015-04-29" version="1">MATSTMKTSFIAIILAGMVAGMVKAQCGNTCSATECCSRFGFCGTGDDFCGVNCRGGPCVNNGVSIADIVTQEFFDGILNQAASTCVGRSFYSRGVFLDALNSFTQFARIGSVEDSRREIAAFFAHATHETGSFCHIEEDGGASKDYCDETRTDYPCNPSKGYYGRGPLQLTWNYNYGPAGSDIGFNGLDAPETVANDPLISFKAAIWFWMNNVAGVMNQGFGATIRAINGDLECNGVDPTKVQSRINYYTQYCSQLGVAPGDNLSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4P1</accession>
    <name>A0A0D2P4P1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine protein phosphatase 2A regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G074200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phosphatase 2A regulatory subunit B56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4P1"/>
    <dbReference type="STRING" id="29730.A0A0D2P4P1"/>
    <dbReference type="Gramene" id="KJB40702">
        <property type="protein sequence ID" value="KJB40702"/>
        <property type="gene ID" value="B456_007G074200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40703">
        <property type="protein sequence ID" value="KJB40703"/>
        <property type="gene ID" value="B456_007G074200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40704">
        <property type="protein sequence ID" value="KJB40704"/>
        <property type="gene ID" value="B456_007G074200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40705">
        <property type="protein sequence ID" value="KJB40705"/>
        <property type="gene ID" value="B456_007G074200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802421"/>
    <dbReference type="eggNOG" id="KOG2085">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCMSSSH"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000041">
        <property type="entry name" value="Serine/threonine protein phosphatase 2A regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF60">
        <property type="entry name" value="SERINE_THREONINE PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B' DELTA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB40702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="523" mass="59992" checksum="77BCC64587E5F391" modified="2015-04-29" version="1">MIKQILNRLPRKPSKSSDNREGGTSTSSSNAYTSSRNSDLASNHYANSSGASFSGFHSTNSGLNQGNKISQVVNAKLNGNTVATSFEPLPNFRDVPNSEKQNLFIRKLNICCIVFDFTDPTKNVKEKDIKRQTLLEIMDYVSSANGKFSEIVMQEIVKMVSINLFRALTSAPRENKVLLAFDLEEEEPSMDSAWPHLQVVYEFLLRFVASPETDAKLAKRYIDHSFVLRLLDLFDSEDPREREYLKTVLHRIYGKFMVHRPFIRKAINNIFYRFIFETEKHNGIAELLEILGSIINGFALPLKEEHKLFLVRALIPLHKPKCIPMYHQQLSYCITQFVEKDCKLADSVIRGLLKYWPITNSSKEVMFLGELEEVLEATQLAEFQRCMVPLFHQIGRCLSSSHFQVAERALFLWNNDHIETLIKQNRNVILPIIFPSLEKNARSHWNPAVQSLTLNVRKIFSDTDPELFEECLHKFEEDQAQENEVKSKREATWKRLEEIAAMKAASNEPVLVSPKATTRNPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4Z4</accession>
    <name>A0A0D2P4Z4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34e superfamily protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G079200</name>
        <name evidence="3" type="ORF">Gorai_018213</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0589466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4Z4"/>
    <dbReference type="STRING" id="29730.A0A0D2P4Z4"/>
    <dbReference type="Gramene" id="KJB40832">
        <property type="protein sequence ID" value="KJB40832"/>
        <property type="gene ID" value="B456_007G079200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802471"/>
    <dbReference type="eggNOG" id="ENOG502RM6V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVYMFIG"/>
    <dbReference type="OrthoDB" id="1865221at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996">
        <property type="entry name" value="OS05G0488500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46996:SF4">
        <property type="entry name" value="RIBOSOMAL PROTEIN L34E SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB40832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0589466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26160" checksum="61E8521B3702C3C3" modified="2015-04-29" version="1">MVYFRNSISVCNSVDQASSAPIMASSVNSNDLVMNNKSSSSSSRNNLYKKQKVFNSPSCLKIPSCERSRSAAIDVVILIAVIAACGFLLYPTIKCLSLKLIGFIGTAFYVIGEEIMRAPMIYGSIGLGFSCAAIAAWILLLCTTKKCRNPNCKGLRKAAEFDIQLETEECVKNSCTLVKDGVKKGLFELPRDHHKELEAELKKMAPVNGRAVLVFRARCGCSVGRLEVPGPKKQRKIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PAZ0</accession>
    <name>A0A0D2PAZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G1761002</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PAZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2PAZ0"/>
    <dbReference type="Gramene" id="KJB42947">
        <property type="protein sequence ID" value="KJB42947"/>
        <property type="gene ID" value="B456_007G1761002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCNHENE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF378">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248716" description="Protein kinase domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="282"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="599" mass="67333" checksum="94C24878D6343B5D" modified="2015-04-29" version="1" fragment="single">IILWLVSPGLLAFVGSICPCLKDHKPAALLGLHGLYGIECWLHADQLQQKALIRMDTRPAGTIGYVNPEYALYGELTEKSDVFSFGVVLFEVVFGKKAFNRRSFWNEKHMLELATESLWKGTIYHDIDPYLKGRIAPECLNKYLEIASSCVHRKGNERPSMGEVELALEMQERADSKMESINPCLHEEELFCGFVRNFSGLDSFLDYEFSYHNSFNFKDSDSNNSNHNTFFYKVFQKGTGDGKLEYSEGNEKRSKIRNPAALPEEINYKFSLALVKAATNNFDQGLIIGSGGFGHVYKGFLNDWNLVIAVKRLHPDSAQGFNEFQAELLLLCQLHHQHVVPLIGFCNEKAEMILVYEYMENGALRDLLYDSGCDPLPWKQRLEICIGAARGLRYLHTGAKQAIIHRDVKSSNILLDDKLVCKLSDFGLAKLRPRSNCKQKTLTRIDSMVKGTCGYADPEYVAGFGLTEKSDVYSFGVVLFEVLCGRQAFDMSLNANQAYLVHWARRSIGEGTIYNIIDPNLKGRIAAGCFKTFVDIACSCTCPEGNSRLEMGEVEVMLERALELQQKADSDMVRLASCGVYMFEEVSCCALVPEYSSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PN05</accession>
    <name>A0A0D2PN05_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor isoform 4E</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">eIF-(iso)4F 25 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">eIF-(iso)4F p28 subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G053200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners. In higher plants two isoforms of EIF4F have been identified, named isoform EIF4F and isoform EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has subunits p82 and p28.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PN05"/>
    <dbReference type="SMR" id="A0A0D2PN05"/>
    <dbReference type="STRING" id="29730.A0A0D2PN05"/>
    <dbReference type="Gramene" id="KJB28523">
        <property type="protein sequence ID" value="KJB28523"/>
        <property type="gene ID" value="B456_005G053200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796766"/>
    <dbReference type="eggNOG" id="KOG1670">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EEFWAIV"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF60">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR ISOFORM 4E-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB28523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="23225" checksum="E341388AFA22AECF" modified="2015-04-29" version="1">MASEAAVEVNAISAAAPEAEATTGAEKQPHKLERKWTFWFDNQSRPKQGAAWGTSLRKVYTFDTVEEFWCLYDQIFKPSKLPGNADFHLFKAGIEPKWEDPECASGGKWSVTSNRKANLENMWLETLMALIGEQFDEADEICGVVASVRQRQDKLALWTKTATNEAAQMGIGRKWKEIIGVNDKITYSFHDDSRRERSAKGRYNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PS26</accession>
    <name>A0A0D2PS26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G155600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PS26"/>
    <dbReference type="STRING" id="29730.A0A0D2PS26"/>
    <dbReference type="Gramene" id="KJB09674">
        <property type="protein sequence ID" value="KJB09674"/>
        <property type="gene ID" value="B456_001G155600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796043"/>
    <dbReference type="eggNOG" id="KOG1745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="74"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB09674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="168" mass="18587" checksum="4CFE4F5FAC616779" modified="2015-04-29" version="1">MSRTKHTAAKKPRRKPSAAAAASPATASPHTRSCKTNLSQIRNLLFLKVTAKKTGGPGTPTPGNLKRPHRFRAGTRALQEIRKYQKTSNLLVPAASFIREVRAISYRFAPDISRWQAEALVAIQEAAEDYLIQLFGDAMLCAIHAKRVTLMKKDIQLARRLGGMGQPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSH0</accession>
    <name>A0A0D2PSH0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G166800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSH0"/>
    <dbReference type="Gramene" id="KJB09794">
        <property type="protein sequence ID" value="KJB09794"/>
        <property type="gene ID" value="B456_001G166800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="116" mass="13333" checksum="E5C49ADDB4AAABB7" modified="2015-04-29" version="1">MICRRDCPSLMSLPKNGLKVALISRTWNSVIRLSGLTLRSRVNLPLAALFEREYALIDADDGVRRDSFKPRVWTVEKERAPSLEEFDHQRGFFNYSLKGGALPAKDLELEGRRMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PXA2</accession>
    <name>A0A0D2PXA2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Outer envelope pore protein 16, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G110700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PXA2"/>
    <dbReference type="STRING" id="29730.A0A0D2PXA2"/>
    <dbReference type="Gramene" id="KJB08881">
        <property type="protein sequence ID" value="KJB08881"/>
        <property type="gene ID" value="B456_001G110700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791378"/>
    <dbReference type="eggNOG" id="ENOG502RZS0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERICGTR"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF2">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 16-1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15435" checksum="565855B7B10FF223" modified="2015-04-29" version="1">MPSTRFLGSLSTPRVDITIDTGNLFFNHALEGFLKIGSVAATRSIAEDSFKAINGGKLSKHCLERSLKKMCKEGAYWGSVAGVYVGMEYGVGRIRGTWDWKNAMIGGALTGALVSAATNNNKDQIVSDALTGGAVATASVLLNYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q437</accession>
    <name>A0A0D2Q437_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G249000</name>
        <name evidence="12" type="ORF">Gorai_021833</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q437"/>
    <dbReference type="Gramene" id="KJB11236">
        <property type="protein sequence ID" value="KJB11236"/>
        <property type="gene ID" value="B456_001G249000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767414"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWKASSM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000530">
        <property type="entry name" value="ABC transporter G family member 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF126">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 20-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="50"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB11236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0579582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="685" mass="75722" checksum="3AB325C929F91232" modified="2015-04-29" version="1">MEIEELPCEEHHQILDIHIAGSSYPPFVLSFKNLTYDVKVSTKSGFPFRWKKPSVSSGNTTKSLLRGISGEAKEGETMAILGASGSGKSTLIDALANRISKQSLKGSITLNGEVLDSDVLKVISAYVMQDDLLFPMLTVEETLMFSAEFRLPRSVSKSKKKARVQGLIDQLGLRNAAKTVIGDEGHRGVSGGERRRVSIGIDIIHDPILLFLDEPTSGLDSTSALMVVKVLQRIAEGGSIVIMSIHQPSSRILGLIDRLIILSQGRTLYSGSPSNLPQFFSDFGHPIPNNENPSEFALDLIRELEGTSSGTQILFEFNKTWKASSMDDNGGDDTISNRRCTLPLKDAIAKSISRGKLVSGGNGANHSSSVPSFANPFYIELMVLSKRLLTNSRRMPAKFAVRLGTITVTGIVLATMFWQLDDSPAGVQERLGCISISIATIFFNCITEVPTFIQERYIFMRETAYNAYRRSSYVLARSLTHIPLLFNLSVTLSLITFWTVGLAGGVPGFLFFFVTILASFWAGSSFAAFISGVIPDVFLAFVSGIAIVSYYLFLCGFLVARDRLPKYWLWFHYISLVKYPYEAILQNEFLDPTKCFVLGVQLFDQSALATLPAPVKSELLESLGRVVGRNITRSTCLTTGKDILKQQGIVELSKWKCVWVTVAWGFFFRILFYLTLLFGSKNKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q4H3</accession>
    <name>A0A0D2Q4H3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G258100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q4H3"/>
    <dbReference type="STRING" id="29730.A0A0D2Q4H3"/>
    <dbReference type="Gramene" id="KJB11426">
        <property type="protein sequence ID" value="KJB11426"/>
        <property type="gene ID" value="B456_001G258100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768315"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEVWTNT"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001122">
        <property type="entry name" value="AAA-ATPase ASD, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="244"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="316"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="470"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB11426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="523" mass="60028" checksum="55BEF44D8CDE7BF2" modified="2015-04-29" version="1">MVMMKGEQWSNLGSTMAAIMFVYAMLRQYFPPQLQDYIFRYGKKLSNFMYPYIHVTFDEFIGERMKKSEAFSAIQNYLSDKSSANAKRLKADVVKDSQSLVLSMDYNEEITDEFNGIKLWWSAKRTTPKTQQFSFYPGADEKRFYTLKFHKRDRQVITGIYLSHVLKQGKAIAADNRQRKLYSNGAGQGWLGNRSSTTWTHVAFEHPATFDTLAMDEKKKREIKKDLVKFSNGKEYYAKIGKAWKRGYLLYGPPGTGKSTMVAVMANFLNYDVYDLELTTVKNNVELRRLLIETSNKSIIVIEDIDCSLDLTGQREEKKKKKKKDDKNEEGDPISAMSKNEERKESEVTLSGLLNFIDGIWSACGGERIIVFTTNHVEKLDPALIRRGRMDKHIEMSYCRFEAFKVLAKNYLDIDSHPLFGEIGNLLEETDMTPADVAENLMLKSDDDDDDDDDEVETCLKNLIEALKTAKDEASKKAEEDARLKAEKEQKEKEEAEKEQSVKEDVTQHAISAKEVKDNGVIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5C1</accession>
    <name>A0A0D2Q5C1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Knottins-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G029500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEFL family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB11911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q5C1"/>
    <dbReference type="STRING" id="29730.A0A0D2Q5C1"/>
    <dbReference type="Gramene" id="KJB11911">
        <property type="protein sequence ID" value="KJB11911"/>
        <property type="gene ID" value="B456_002G029500"/>
    </dbReference>
    <dbReference type="OMA" id="CHHHEEA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050832">
        <property type="term" value="P:defense response to fungus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00107">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.10">
        <property type="entry name" value="Knottin, scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008176">
        <property type="entry name" value="Defensin_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003614">
        <property type="entry name" value="Knottins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036574">
        <property type="entry name" value="Scorpion_toxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33147">
        <property type="entry name" value="DEFENSIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33147:SF39">
        <property type="entry name" value="DRO1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00304">
        <property type="entry name" value="Gamma-thionin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00288">
        <property type="entry name" value="PUROTHIONIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00505">
        <property type="entry name" value="Knot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57095">
        <property type="entry name" value="Scorpion toxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00940">
        <property type="entry name" value="GAMMA_THIONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0295">Fungicide</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249498" description="Knottins-like domain-containing protein" evidence="7">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Knottins-like" evidence="8">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB11911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8363" checksum="36CFB83F6FAEF254" modified="2015-04-29" version="1">MGQFSRSISAVVLLMLVLLATEMGPVTADGDKICESRSNAFKGLCLRDNNCDIVCKTEGFPNGGCKGFIRKCVCTKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q9Z0</accession>
    <name>A0A0D2Q9Z0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tunicamycin induced 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G211600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q9Z0"/>
    <dbReference type="STRING" id="29730.A0A0D2Q9Z0"/>
    <dbReference type="Gramene" id="KJB16074">
        <property type="protein sequence ID" value="KJB16074"/>
        <property type="gene ID" value="B456_002G211600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ67">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIMIADP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053283">
        <property type="entry name" value="TUNICAMYCIN_INDUCED_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454:SF2">
        <property type="entry name" value="PROTEIN TUNICAMYCIN INDUCED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34454">
        <property type="entry name" value="TUNICAMYCIN INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB16074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="61786" checksum="76F0F7DE3B386684" modified="2015-04-29" version="1">MAVMYIASAAKLWWCSKFVNDVKMKSEGAVRARSKKALLKYSHGLGAKVFTWFIAQHGNGAHANPNQSHFLFASFSASNWLCNATSPPLTSSTTHLLTSHTTHTFNPKDYRNIQPQSSNLDSDLGFLFSFTVVVCGGWTTIMIADPKSCDVLFVFVLFAIISSSNALVSTPYPKAISDLKEAVVKGLGFQADDFKISGFDLRDALVGHSVAYEFDIEIDNKVIPFKLLEDVNRWEYVDLPIFRVEEPARPGVENGLVEHKRISDNGLPVLAPFQLAGPMELWIQDAKDMRISLPHDVDAGVLKKVMLADGAVVTVKGARSVSLRHPIDLPLPLSRTHNGFASGLMAIAEHLRRASCSQDAPLLSLRIVGPTSLTVPSSSNNKLKLKRLAPGLVELSSMSKTKTMDALSTIDLQGEAATVLTPKHFSTMWPFASINGSNANLIGFERLLSSVLDSKANKKGYFKLLKADVSAQTFVKIGFGIEKMLKEGDGFNLEGFPEWRTKPEIVSMHFEVLAKVDGENVIPERIMQVNPVAVEDAIAPHVLARNMTMSSTPVVYTPSNPFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAA2</accession>
    <name>A0A0D2QAA2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G218900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QAA2"/>
    <dbReference type="STRING" id="29730.A0A0D2QAA2"/>
    <dbReference type="Gramene" id="KJB16234">
        <property type="protein sequence ID" value="KJB16234"/>
        <property type="gene ID" value="B456_002G218900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786124"/>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCGFNIP"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000001">
        <property type="entry name" value="Mitochondrial transcription termination factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF130">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF6, CHLOROPLASTIC_MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB16234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="43214" checksum="CFED5774C33540B0" modified="2015-04-29" version="1">MAPPIIRSLIAFSLNKSCRSQKPISGYSISSVFFSSSPTQESRASLPLADHLVEKHSFSPELAVKTASSLTYVKDPRKCDTIISFLKESGFSKSHIEAVVKRKPNLLYSSLEKTIKPKFKIFQDLGFSTHDVADIVASDPWILTRSVDDRIAPSISDLKTVLGSNDDVVKLLKTSAWFLKSDLQKTMMPNIEFLRNCGICSSQIVSYVFSFPRFFLLKPESIKQFVERADALGFDRKSNMFLAAIRMLSSMSEENWELKLKLFRKLGFSEDDIMSTFRRTPQVFAVSERKIKQVTDFLLNRTNVGISFIISHPMVLICSLERRLKPRLLVIKTLESKNSLRRKVSMTTIYKMPDKKFREKYVVPYLKELEEVSMSIVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QE80</accession>
    <name>A0A0D2QE80_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G208600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QE80"/>
    <dbReference type="STRING" id="29730.A0A0D2QE80"/>
    <dbReference type="Gramene" id="KJB37518">
        <property type="protein sequence ID" value="KJB37518"/>
        <property type="gene ID" value="B456_006G208600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800230"/>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTMGVDM"/>
    <dbReference type="OrthoDB" id="1923658at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051863">
        <property type="entry name" value="HIPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811:SF50">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="7">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB37518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="145" mass="15430" checksum="ED6B3463C4EA5294" modified="2015-04-29" version="1">MKKVVLKLDLHEGKEKQKAMKAVSGLSGVDSISMDMKDKKLTVIGDVDPINIVNKLRKQWHTEILTVGPAKEEKKDGGAKKDEGGGGGGGGGGGGGGGGKKEDDKKKESDQIAELVKAYKAYNPHMTTYYRVVSAEENPNSCIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFF8</accession>
    <name>A0A0D2QFF8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_003G041600</name>
        <name evidence="21" type="ORF">Gorai_024060</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0581898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QFF8"/>
    <dbReference type="Gramene" id="KJB18239">
        <property type="protein sequence ID" value="KJB18239"/>
        <property type="gene ID" value="B456_003G041600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787814"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPRRESK"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000020">
        <property type="entry name" value="ATP-dependent RNA helicase DEAH12 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001279">
        <property type="entry name" value="ATP-dependent RNA helicase DEAH12 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002114">
        <property type="entry name" value="ATP-dependent RNA helicase DEAH12 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000033">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056245">
        <property type="entry name" value="KH_DEAH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056246">
        <property type="entry name" value="KH_DEAH11/12_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056247">
        <property type="entry name" value="KH_DEAH11/12_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056248">
        <property type="entry name" value="RBD_DEAH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056244">
        <property type="entry name" value="RRM_DEAH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF81">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DEAH11, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24471">
        <property type="entry name" value="KH_DEAH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24638">
        <property type="entry name" value="KH_DEAH11_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24641">
        <property type="entry name" value="KH_DEAH11_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24475">
        <property type="entry name" value="RBD_DEAH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24637">
        <property type="entry name" value="RRM_DEAH11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="293"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="487"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="16">
        <location>
            <begin position="1048"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="1537"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB18239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="MBA0581898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1750" mass="196926" checksum="BF5E007FB3A60E82" modified="2015-04-29" version="1">MMNLTSSSNNRHPSPPSDGHKSFQLHSYSNNNHQKPTCPGVNNRYPPSPSTAVSSTDNNTLRPPNFMIQLLKDSPSFRSEPSNLQTLLSQLNPSPEKFHIDPTGKIAASLYFQEWTTTLFSIISLWRSRLEGSHNYTPNLISNVLVPSDNLELQQDLKTLFSNHIKGLMEGELVKEWQKKIDEKSDQIAEVSGQMGKRHYSMGRFFMLNDKKKALNEQSLMISKRLNEFKGGMRSLLRCLEDEKIGKEEQEESVDVFRVDGKLDWERIHQLILRECRRLADGLPIYAHRQEILTRIHGEQIIVLIGETGSGKSTQLVQFLADSGIAANESIVCTQPRKIATVSLAQRVTEESFGCYDDNFVTCYPTFSSAQQFDSKLIYMTDHCLLQHYMNDRNLSGISCIIVDEAHERSLNTDLLLALVKDLLGRRLDLRLIIMSATANADQLSDYFFCCPIFHVTGRNFPVDIQYVPCATEVTSGSGMVAPYVSDVLRMAAEVHKTEKEGNILAFLTSKIEVEWASENFEAPNAVALPLHGKLSFEEQFRVFQSYPGKRKVVFATNIAETSLTIPGIKYVIDSGLVKERKFEPGTGMNVLKVCWISQSSANQRAGRAGRTEPGRCYRLYAASDFESMPSNQEPEIRRVHLGVAVLRILALGVKKVQSFDFVDAPSSKAIDMAIRNLIQLGAIGENNGVFELTVEGRYLVKLGIEPRLGKLILSCFHYGLCREGLVLAAVMADASSIFCRVGNDRDKVKADCFKVQFCHRDGDLFTLLSVYKEWEALPANRKSKWCWENSINAKSMRRCQDTVTELEICLQKELAVVIPSYWFWDPDKTTEHDKCLKAIILSSLSENVAMYSGYNQLGYEVALTGQHIKLHPSCSLLIFGQKPHWVVFGEILSVTNQYLVCVTAFDFESLAILHPPPMFDASKMESQKLQVKAMAGFGNTLLKKICGKSNHNLQSLLSRIRTACMDERIGIEVNFDHNEIRLFALSVDMQKVLAFVNEVLECERKWLFNECMEKFLYHGPNASSSIALFGAGAEIKHLEVEKRCLTIDVFHSNVNTLDDKELLKFFERYSNGSICSVHKSQANGQESDDREKWGKITFLTPDAAQKAAELDGVDFAGSALKVLPSRTSFGGDHKMISFPAVKAKVYWPRRESKGFGFVKCDLLDVGFVIDDLDNLVVGSKTIRCDVSSKSNDAILIRGIDKELSEAEIWDTLQGATNRKIHDFFLVRGDAVENPSCGACEKALHREISHFMPKRNPHTNCCWVQVFQPEPKETFMKALITFDGRLHLEAAKALEHLEGKVLRRCLSWQKITCQRLFHSYISCSSFVYAVIKKQLDSLLASFKRVKGAGCSIEANGNGSYRVRISANATKTVAEMRRPLEELMNGRTIKHAGLTPSILQHLFSRDGIHLMRSLQRETRTYISFDRHSLGVRIFGSPDAAAVAEQKMIQSLLSYHESKQLEVCLRGPGLPPDLMKEVVKKFGPDLHGLKEKIPGSEFTLDSRHHVISIHGDKETKRKVELIVLDIAETGEDLAKKSDCDTTCPICLCEVEDGYWLEGCSHFFCRPCLVEQCESAIRNLDSFPICCAHQGCNVPILLTDLKSLLLSEMLEQLFRASLGAFVASSKGTYRFCPSPDCPSVYRVADPETPGELFVCGACYTETCTRCHGEYHPYLSCEKYREFKEDPDISLKEWCKGKEQVKTCPVCGYTIEKIDGCNHIECKCGRHVCWACLEVFTCSDDCYNHLRAVHMAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGT5</accession>
    <name>A0A0D2QGT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Extra-large guanine nucleotide-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G214300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGT5"/>
    <dbReference type="STRING" id="29730.A0A0D2QGT5"/>
    <dbReference type="Gramene" id="KJB16146">
        <property type="protein sequence ID" value="KJB16146"/>
        <property type="gene ID" value="B456_002G214300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRGPESC"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000013">
        <property type="entry name" value="Extra-large guanine nucleotide-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053057">
        <property type="entry name" value="XLG_GTP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36486">
        <property type="entry name" value="OS01G0977800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36486:SF4">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="498"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="667"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB16146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="720" mass="79986" checksum="C94AD044F05722A8" modified="2015-04-29" version="1">MAGILRKILHVGQSSPPKDDDSNVEYSFAIEYNGPPVSFDIPSAVPVDVDQLPTAATVSSSYVLNNSISLPVIQPVVNTNKMKQNLARHKKIGSGLSNEPSIQVVSLDSLGQTIDGIGSCGIMQNSHVHDSLADDCKQGLGLHNKYMDPPDSDATGSVLSSPSVSSSGVFSQKREDIHNNETTTRHVKRPSVVTFRGPESCDMVQGESNSNYSETQSMHTAEQSIERNGKKGSCYRCLEGNRFTEKEICIVCNAKYCCKCVLRAMGSMPEGRKCVTCIGKKINESRRESLGKCSRLLKQLLNELEVKQAMSSEKTSKANQLPPQLVLINGEPLNQYKLHVLQTCQNPPKKLKPGRYWYDKVSGFWGKEGHGPCQIITAQLNVGGRIKAKASNGNAKVLVNDREITRKELWMLQFAGVNCEGKPSFWLSADGYYQEEGQKNEKGPIWKKTRIKLFCALLSLPVPPNVVNPAGEDVSQRTLEQQVLLKLLLVGYQKSGTSTIYKQAKILYNVPFSEDERQNIKLKIQCNLYGYLAILLEGRERFEEVLLENRKLQFADGPGSSGGASQIDGKTKYSLSPRLKAFSEWLVQVMVSGNLEVIFPAATREYAPFIQELWNDAAFQATYNRRHELQMLPRIATYFLERAVEISRTDYEPSDMDILYAEGTQSSNGLSSMEFSFPTRERESFIDGTNLLDCIPVALGKAASGWECLKMSTWSYFASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGV8</accession>
    <name>A0A0D2QGV8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G216700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGV8"/>
    <dbReference type="STRING" id="29730.A0A0D2QGV8"/>
    <dbReference type="Gramene" id="KJB16186">
        <property type="protein sequence ID" value="KJB16186"/>
        <property type="gene ID" value="B456_002G216700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786100"/>
    <dbReference type="eggNOG" id="KOG1474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1913335at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004252">
        <property type="entry name" value="Probable_transposase_24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47809:SF3">
        <property type="entry name" value="CHROMATIN REMODELER BROMODOMAIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47809">
        <property type="entry name" value="DNA-BINDING BROMODOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03004">
        <property type="entry name" value="Transposase_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="186"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="63"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="491"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB16186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="941" mass="105901" checksum="9B4D8919B971A4E8" modified="2015-04-29" version="1">MRTKQKRACRKPPARKSAALAENVEAVKQGEKAVNQSEKAVNQNERIVNQSEEAFLSFINQNRKGDSVSADSNDLEVVDLDSDEAKSNSSLSSSSSDSDESFSAEESSTDDSSSVDRRSRKSTKRHGNVKQEASKLPNKGRKDDVNSSRVLHSFGKKHDECKMSEQDPRYNTKELKAALEVIKKIMKMDEAQPFSVPVDPVALGKSDYFNVIDTPMDFGTICSNLENSTKYMNTKDVFNDVQYIWENCCKCNQKGEYIVYLMKRVKKKFMKYWIAAGLSIGQSGKSNVGNLFEPSTTDYATRRRGHEPFYPVGSADGASQMQQGQLGFNQHHLYFPSSCYSQPHQLPQPPPSTTRPQFSQLSPVSYHQHHQSQHPPPSTNQPQFSQLQSHTGYSHFQPPGDIAPKHKKQASKKHKKNSSTGPAASILSGSPGQSQQPHLSYKLPYGLQQYQHSINRLQSSQLQGAVDGGHSHFLPQSDYTRSHGYVPYYPVDPMVVPGQSHPQQSRLSDGESSESQERQLKASHCQPQSSQLQHNVDIEHSHTSLTDSALRAIRCALRYSASPKTNKSNQENQGPLGCTKSQPEQSPQRPEQRQFTKKRKGRGPTRCLFLNDLADGERIFVRINKFGQPVGPNSSKLSSFLGTVARNGHRAPLNFIDWRALSDSYKDDMWEYVQTKFDIDPSGKSWVMQSIATKWRDWKADLKATYYDSLNTDEERLKVSDPRVVPDQWPSLISYWNSEDTKKHCARNRANRQKHTCGHSSGTKSYARICEEEQNKRPDGKEPTRAELYILTHTRKNGQPVDDTAAKLISKIREQEAKKQNTLQCSDESNDTLCQVMGEEQGKNVGPYGMGPNRTGIFGPRPGRVVLARMASKAKRSANEEVRKIAVKMEAMEEKYALMEKNIARMTSNMEKFLEKIGGSSNILGSEQRHHEEEDPEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QK06</accession>
    <name>A0A0D2QK06_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Two-component response regulator-like APRR5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G017100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARR-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QK06"/>
    <dbReference type="STRING" id="29730.A0A0D2QK06"/>
    <dbReference type="Gramene" id="KJB39508">
        <property type="protein sequence ID" value="KJB39508"/>
        <property type="gene ID" value="B456_007G017100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801851"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PDTSENH"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17582">
        <property type="entry name" value="psREC_PRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF95">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR-LIKE APRR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="56"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="12">
        <location>
            <begin position="578"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="502"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="553"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB39508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="70175" checksum="78DAFD4B905673E3" modified="2015-04-29" version="1">MGEVLMSSDEVKTESEIDRENGEFEGNKRRKKMSGGSFVSVEAVNWESFLPTMALRVLLVEADDSTRQIVTALLRKCNYRVSAVSDGLQAWEMLKAKPHNIDLILTEVDLPSISGFALLTLIMEHKICKSIPVIMMSSQHSISTVYKCMLRGAADYLVKPLRRNELRNLWQHVWRRQSLIASGNTPQDESVGQKKIEAISDNNAASNRSSGCLVGGERNKEQTEKGSEAQSTCTKPDVEAEDANMENMQEFLLLPSNSQKHEVQMDFNQRLLVHEKETGVDGACKDTKISVEAGDAVGDSPRKAIDFMGTFDRNCNSSSMNSTSKVGSSTHLDFSLGRCSPNAFENHATREKPTLWHPNSSAFTRYSSRPSQPLQSTLTSVSDQKKESGTDSEKMLPNSIDEYNSDTPSPKLTPQRNTNPLTTGSTGQLRQTEVAASCTQQVVLPVLVPSPSLANQKELACCVNPFHHPSFESNSSGQFYDRLASNTNQLTNQPLQKLDQKMNSTEDRGHISPTTDQSATSSFCNGSLSQLNGIAYGSTAASNNSNIDQEAVVRASADSKNDDVFPSPTGNSHRSIQREAALTKFRLKRKDRCFEKKVRYESRKKLAEQRPRVKGQFVRQPQADLSHYGNSSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QK11</accession>
    <name>A0A0D2QK11_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">(+)-abscisic acid 8'-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_003G129900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-cis-(+)-abscisate + reduced [NADPH--hemoprotein reductase] + O2 = (+)-8'-hydroxyabscisate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12897"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:37569"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58490"/>
            <dbReference type="EC" id="1.14.14.137"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Plant hormone degradation; abscisic acid degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.137" evidence="14"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QK11"/>
    <dbReference type="STRING" id="29730.A0A0D2QK11"/>
    <dbReference type="Gramene" id="KJB20034">
        <property type="protein sequence ID" value="KJB20034"/>
        <property type="gene ID" value="B456_003G129900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788803"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DDTRQMP"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010295">
        <property type="term" value="F:(+)-abscisic acid 8'-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000014">
        <property type="entry name" value="Abscisic acid 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF220">
        <property type="entry name" value="ABSCISIC ACID 8'-HYDROXYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB20034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="499" mass="56963" checksum="635B4A82342DC8D2" modified="2015-04-29" version="1">MQLLFSSLPLPPHTFLPTFTAFYGCHLPFLITPIVLFYLMVVLVVVTLLLLLSVHQWRRPKDKPLPPGSMGWPYIGETLKLYKENPNSFFANRQKRYGDIFKSHILGCPCVMISSPDAAKIVLVTKAHLFKPTYPPSKEKMIGPEAIFFHQGPYHSRLKKLVQASFLPSAIRGSVSEIEQIVLKFLPAWENTTLNTLQEMKRYAFDVAMISAFGHKQDKEINGIKQLYQCLEKGYNSMPLDLPGTPFNKAMKARKLLNETLRRLIKERRENEKQGGGGLLGVLLGDKNQKVDQLSDSQIADNVIGVIFAAHDTTASVLTWLLKYLHDNENLLEAVTREQEGVRREIIEANRRLMWDDTRHMPLTTRVIQETLRTASILSFTFREAVEDVEFEGYYIPKGWKVLPLFRTIHHCADFFPKPEKFDPSRFEVPPKPNTFMPFGNGVHSCPGSELAKLEMLVLLHHLTTKYRWQVVGDEDGIQYGPFPVPKKGLPVKVTPRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLY4</accession>
    <name>A0A0D2QLY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G234400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLY4"/>
    <dbReference type="STRING" id="29730.A0A0D2QLY4"/>
    <dbReference type="Gramene" id="KJB58992">
        <property type="protein sequence ID" value="KJB58992"/>
        <property type="gene ID" value="B456_009G234400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46281:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="191" mass="20784" checksum="37065C95544F3D79" modified="2015-04-29" version="1">MADAQTEKPLSLSEQYALQEKEEKSDVTTKPAEAKEVENPVNAATGSGDVVTEKLEETSADPVEGSTEAPPPAAEESTEANPATGNSGEDAAEENSGDSEETPEIKLETAPADFRFPTTNQTRHCFTRYIEYHRCVAAKGEGAPECDKFAKYYRALCPGEWIDGMSKGRMVLFQVLSRWDGTPIVAEKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNC2</accession>
    <name>A0A0D2QNC2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G047600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily. ABCF family. EF3 (TC 3.A.1.121) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNC2"/>
    <dbReference type="STRING" id="29730.A0A0D2QNC2"/>
    <dbReference type="Gramene" id="KJB18341">
        <property type="protein sequence ID" value="KJB18341"/>
        <property type="gene ID" value="B456_003G047600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787876"/>
    <dbReference type="eggNOG" id="KOG0927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000309">
        <property type="entry name" value="ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051309">
        <property type="entry name" value="ABCF_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42855:SF1">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="96"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="423"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="644"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00061344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB18341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="690" mass="78350" checksum="8BCFE5E49611D505" modified="2015-04-29" version="1">MDLSTKFHRLDLRSTFFTSLRPSLTRNSSSVVSPKTLKFRPTKVNAQVSTLSVETSVKEPQNDIESLFSTNTVEEIDRKRGNKQSNTGASGISSGVKLENISKSYKGVTVLKNVNWEVKKGEKVGLVGVNGAGKTTQMRIITGQEEPDSGNVIKAKPNMKVAFLNQEFQVSMSRTVREEFMSAFKEEMEISERLERVQKAIEGSTEDLELMGRLLDEFDLLQRRAQAVDLDEVDAKVSKLMPELGFSPEDSDRLVASFSSGWQMRMSLGKILLQEPDLLLLDEPTNHLDLDTIEWLEGYLKKQDVPMVIISHDRAFLDQLCTKIVETDMGVSRTFEGNYSQYVEAKAAWIETQYAAWEKQQKEIEQTRDLISRLGAGANSGRASSAEKKLERLQEEGQIEKPFQRKQMKIRFPERGRSGRSVVTIKNLEFGYEDELLFNRANLAIERGEKIAVIGPNGCGKSTLLKLIMHLEKPRGGEVILGEHNVLPNYFEQNQAEALDLDKTVLQTVEEVAEDWRIDDIKGLLGRCNFKADMLDRKVSLLSGGEKARLAFCKFMVKPSTLLILDEPTNHLDIPSKEMLEEAIREYSGTVITVSHDRYFIRQIVNRVVEVKDGHLQDYAGDYNYYLEKNLEARVKELEREADLEEKAPKLKAKSKMSKAEKEARKKQKMQAFQAAKQKSKGMKNSKRWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNR1</accession>
    <name>A0A0D2QNR1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G055700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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                <person name="Byers R."/>
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                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QV62"/>
    <dbReference type="Gramene" id="KJB11055">
        <property type="protein sequence ID" value="KJB11055"/>
        <property type="gene ID" value="B456_001G238300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766189"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LVLHIIV"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042937">
        <property type="term" value="F:tripeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17417">
        <property type="entry name" value="MFS_NPF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044739">
        <property type="entry name" value="NRT1/PTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67925" checksum="7EB243C064EB378D" modified="2015-04-29" version="1">MAKELAEEKGSANGRDDDYTEDGSVGLKGRPVLRSITGRWKACSFIVGYEVFERMAYYGIASNLVVYLTRELHEGTVKSSNNVNNWVGTVWITPVLGAYIADAHLGRYWTFLIASAIYLSGMCLLTLVVSVPALRPPSCGHGYKAINCNKRASGFQKGIFYCALYIIAVGTGGTKPNISTMGADQFDDFEPKERVQKLSFFNWWMFSIFFGTLFSNTFLIYIQDNVGWSLGYGIPTIGLLVSVLVFLVGTPFYRHKLPLGSPFTRIFQVLVAAVRKWNMPVPTDPKELHELSLEEYSKSKQFRIDYTPSLRFLDKAAVKTGPNSAWKLCPVTQVEETKQMVKMVPILVATFIPSTLVAQMGTLFIKQGTTLDRSMGPHFQIPPACLTAFVTIFMLISIVLYDRYFVPIVRRYTNNPRGITLLQRMGIGIILQIIVMIIACFAERKRLSVAREHQKLGAYDSIPLSIFILLPQFALVGVADAFVEVAKLEFFYDQAPEGMKSLGTSYFTSSIGIGHFLGSFILTTVSDMTKRHGHRGWILDNLNTSHLDYYFAFLAALGFLNFLIFLAVAKLFVYNADVKESDTGLQEATDASQNKASSKVEALRAGTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVZ2</accession>
    <name>A0A0D2QVZ2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G100600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVZ2"/>
    <dbReference type="Gramene" id="KJB21321">
        <property type="protein sequence ID" value="KJB21321"/>
        <property type="gene ID" value="B456_004G100600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB21321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="66" mass="7845" checksum="0159D1A8A22135B1" modified="2015-04-29" version="1">MQRNQNAIKKVKTSFFFSRTSNFSLIFLVRLSRPFVFHRLSCVARNIVFQCFCCKRGTHLSMQDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QWW2</accession>
    <name>A0A0D2QWW2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G002400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QWW2"/>
    <dbReference type="Gramene" id="KJB21601">
        <property type="protein sequence ID" value="KJB21601"/>
        <property type="gene ID" value="B456_004G002400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21602">
        <property type="protein sequence ID" value="KJB21602"/>
        <property type="gene ID" value="B456_004G002400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1927">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="70874at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21865">
        <property type="entry name" value="DEUBAD_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044867">
        <property type="entry name" value="DEUBAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024867">
        <property type="entry name" value="NFRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057748">
        <property type="entry name" value="NFRKB_WH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052:SF0">
        <property type="entry name" value="DNA-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13052">
        <property type="entry name" value="NFRKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25793">
        <property type="entry name" value="WHD_2nd_NFRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51916">
        <property type="entry name" value="DEUBAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEUBAD" evidence="4">
        <location>
            <begin position="94"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="899"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1236"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1276"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="579"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB21601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1339" mass="151084" checksum="16E017CB180F2C80" modified="2015-04-29" version="1">MMAIEKNNFKVSRFDSEFSSDSRDTTSSTDEDELQRPSSAINSDGAGDDDDEDDDDDEFDDADSGAGSDDFDLLELGEMGAEFCQVGNSTCSVPFDLYDLPGLEDILSLDVWNECLSDEERFSLTKFLPDMDQDTFMWTLNDLLKGNNFHFGSPIKKLFDILKGGLCEPRVALYREGLNFFQKRRHYHHLRMHQNNMVAKLCQTRDAWLNCRGYSIEERLRVLNIMRSQKILVYEKSEDEDSESSERGDFGEGLWTKRVKDQKALQKKGHHGVGPTLESVSRGQMVGLEPSEYRKQNPKGILKARGSKFPSAKEFGGGVYQGLDIDTEPYGLHGTLPRHKYKSGAANRTRDQMRLDDDGDPMFGTSIQQDRHAVHDSKSRKSGLLRAGKKYGLLRGEELAGDSFMALPLSSKHDSRAYGRNRNVNQFPDAKVYTSKPPNMRTPYDFAKTSKYSENHQQFAVGNQIKLMKGRTPQLPLKGSRFDLSERTELFWQNKNQGEDFSVDSSVRSDDWNIRSRKCKMGPQCPDKASLQQMNDRFLFSDNRIKSSQEKIRGSNVQNGGPLMAVSKGSRAFLKNEETESDSSEQFDDDDDSNPLMRSKFDYPSGVMEGSRLSSLKSGLDSRKIKSSKKDTMEDGWPLDGINRISEKSFGENVHVPGVESYYFKGKQKSKMHEISPLQNSASRALGKVDRKKVSKLSKTGQLGEKLGDRLKMSSTKAYPTEKRLKGEVVYDHPMSQRDYLLNYPVDEEDASPVTLPLADENNRRRTGKKGRSIETYDCGEKREASLLGCKTGKEYVGDVDRRGEDGNLQSNLQKRTDDSLSLKKKGKRKLEVDAVTSDMEALEPHGAEVQVTDVEMEIKPQKKPFTLITPTVHTGFSFSIIHLLSAVRMGMITPLPEDSLEVGRPRREQNGKQEGGVNGVLSCENTATDNPDQPVQRSIPSLTVQEIVNRVTVNPGDPCILETQEPLQDLVRGVLKIFSSKTAPLGAKGWKALVAYEKSTKSWYWVGPIMHSSIDHETIEEMTSPEAWGLPHKMLVKLVDSFANWLKNGQETLQQIGSLPAPPLELMQVNLDEKERFRDLRAQKSLNTIGPSSEEVRAYFRREELLRYSIPDRAFSYTAADGKKSIVAPLRRGGGKPTSKARDHFMLKRDRPPHVTILCLVRDAASRLPGSIGTRADVCTLIRDSQYIVEEVSDAQVNQIVSGALDRLHYERDPCVQFDGERKLWVYLHREREEEDFEDDGTSSTKKWKRQKKDTAEQSDQGAVIVAFHATGNQLGFDDDKKMETECEDRQNPEDNADDSHASEQGHPITWEPLDANLVQEDKLLCEENSTNEEFDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0J3</accession>
    <name>A0A0D2R0J3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G017500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0J3"/>
    <dbReference type="Gramene" id="KJB63807">
        <property type="protein sequence ID" value="KJB63807"/>
        <property type="gene ID" value="B456_010G017500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772498"/>
    <dbReference type="eggNOG" id="ENOG502QSAS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRFHINC"/>
    <dbReference type="OrthoDB" id="1883418at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34211:SF3">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="876"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB63807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117122" checksum="B2ED767CF4DD92EC" modified="2015-04-29" version="1">MGSDKRSAGLLPRMERVRTILTHKYRYPHEHSRHAIIAVVVGCLFFISSDNMHTLIEKLDNNIKWWSMYGCLLGFFYFFSSPFIGKTIKPSYSNFSRWYIAWILVAAVYHLPSFQSMGVDMRMNLSLFLSIYLSSILFLLVFHIIFFGLWYLGLISRVAGRRPEILTVVQNCAVISIACCVFYSHCGNRAMLKQKPSVRKNSIWFWEKGERNTWLANFLRMNELKDQVCSSWFAPVGSASDYPLLSKWVIYGEIACSGSCSGPSDEISPIYSLWATFIGLYIANYVVERSTGWALTHPLSVEEYEKLKKNQMKPDFLDMVPWYSGTSADLFKTVFDLLVSVTVFVGRFDMRMMQASMSRVHEGAQQYDLFYDHLSEREDLWFDFMADTGDGGNSSYAVARLLAQPSILLTKDDSLLTLPRGDLLLIGGDLAYPNPSRFTYERRLFCPFQYALQPPPWYKPDHIAVNKPELPEGVSELKEYNGPQCFIIPGNHDWFDGLNTFMRYICHKSWLGGWFMPQKKSYFALQLPKRWWVFGLDLSLHADIDVYQFQFFSELVKTKVGENDSVIIMTHEPHWLLDWYWNNVSGENVSHLICDYLKGRCKLRIAGDLHHYMRHSCVPSEGPVHVQHLLVNGCGGAFLHPTHVFSNFSQFYGKTYECKAAYPSFDDSSRIALGNILKFRKMNWQFDFIGGIIYFILVFSIFPQCQLDHILQDDSFSGHLRSFFGTVWNSFVYMLEHSFVSLAGVVLLLMLAFTFVPSKLALKKRAIIGILHVSAHLASAVILMLLLELGLETCIRHKLLATSGYHSLYQWYQSVETEHFPDPTGLRARIEQWTFGLYPACIKYLMSAFDVPEVIAVTRSNICKYGIQSLSRGGAIIYYASVFLYFWVFSTPVVSLVFGSYLYICINWLHIHFDEAFSSLRIANYKSFTRFHINCDGDLEVFTLAIDKVPREWKLDPDWDGEAKQPQQWSHRIKHPSKWSASVSHQDPLNTVRIVDRFIIKQTDNQDFASSNGSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1Z7</accession>
    <name>A0A0D2R1Z7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G071700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1Z7"/>
    <dbReference type="Gramene" id="KJB13385">
        <property type="protein sequence ID" value="KJB13385"/>
        <property type="gene ID" value="B456_002G071700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779189"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADYDIME"/>
    <dbReference type="OrthoDB" id="429961at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717">
        <property type="entry name" value="OS12G0527900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45717:SF7">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="383"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="58193" checksum="4322087709433F8A" modified="2015-04-29" version="1">MASRTLFTILNNKKTKTLTADWLVMTRAYCVAPNPANINSLYSRINAIGDPNCSVTPVLQQWVKGKNVKEFQLQRLIRDLRSRRRYTHALEVSKWMSSSDLEFSSSDYAVQLDLIGRVNGLTAAKNFFSSLRDQDKTVKTYGALLNCYVRVGLIDESLSLMKKMKEMGFLSSPLNYNNLMCLYTHRGQFEKVPDVLFEMKTNGVSPDKFSYKICINSYGARADYDIMEKVLQEMDSERDIQMDWCTYSLAANYYIKAGLKEKALHYLKECEKKVGNDAEGYDHLISFYARLGNKDELKRLWDLQKSKCRKQTNKNYIVMLGSLVKLGELEETEKLIDEWELSCKTYDFRVPNVLLIGYCQKDLVEKAEAKLQDIIKRRKIAIPNSWSIVATGYMNKNKMEKAFECFKEALAIQTQNRGWKPKAGLISSILSWLGENGEVEDAEAFVKLLRTKVPVNREMYHALLKAYIRNGKEVEGLLVSMKDDKIDENGDTMKILSLQDQNSEVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2X4</accession>
    <name>A0A0D2R2X4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G318300</name>
        <name evidence="3" type="ORF">Gorai_019906</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2X4"/>
    <dbReference type="Gramene" id="KJB45653">
        <property type="protein sequence ID" value="KJB45653"/>
        <property type="gene ID" value="B456_007G318300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761237"/>
    <dbReference type="OMA" id="NISAEHV"/>
    <dbReference type="OrthoDB" id="1577729at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB45653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0591224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="117" mass="13216" checksum="CBD41375A044124C" modified="2015-04-29" version="1">MVYISRNVSNTDRGLNIGSFLKNLSKFAVDSAINVSLKGFTGGKKLYQTFLQEKLKDEASNVKLMKEETQSTKMEDIANKAVGGTEPVKKKKMVPQDSKEMELEDPKRKTIFIRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5L1</accession>
    <name>A0A0D2R5L1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_002G137000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5L1"/>
    <dbReference type="Gramene" id="KJB14675">
        <property type="protein sequence ID" value="KJB14675"/>
        <property type="gene ID" value="B456_002G137000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF117">
        <property type="entry name" value="CSC1-LIKE PROTEIN RXW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="605"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="686"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="13">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="14">
        <location>
            <begin position="186"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="12">
        <location>
            <begin position="410"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB14675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="91773" checksum="909AB9FC408924E6" modified="2015-04-29" version="1">MDIGALLTSAGINIAICVVLLSLYSILRKQPSNVSVYFMRRLISEPIKHSDPFRFERLVPSASWIVRAWQATNEEILAAGGVDALVFLRIVVFSIRVFIIAAMICVFLLLPVNYYGQEMQHKQIHSESLEVFTIGNVKEGSKWFWTHCLALYVISCSACVLLHFEYKNITKMRLAHITGSPVNPSHFTVLVRSIPCSQNHSYSKSVEDFFSTYYPASYVSHQMVYRAGRVDKLMKDAEKMYRMLKTIESTTKKSYMPCCLCGKSTHSFEALNNDAESVEIKTSSDELQPSQREKKDVEKIYRKLKTIETQNKMSSTPGCLCGGIMHYFKMLKKEAESVECKTSSDRSQPSQTGKERPAAFVFFRTRYAAIVAAQVLQSSNPMLWVTQLAPEPNDVYWSNLSIPYKQVWLRKIATLLGAFVFMFVFLAPVTFVQGLTQLDQLRQTFPFLKGILKQKFMNQLVTGYLPSVILMLFMYAVPPTMMLFSTIEGNVSHSERKKSAGIKVLYFTIWNVFFVNVLSGSIIRQLSVFSSFRDIPTQLAKAVPTQATFFTTYVLTSGWASLSCEVIQLFPLLCNGFRRFILRRQEEPCSNHALTFPHHTEIPRLLLFGLLGFTCSIMAPLILPFLLVYFFLAFLVYRNQILNVYVPKYESGGQFWPVVHNTTIFSLVLTQVIALGVFGIKRSPVASGFTIPLIFLTLLFNEYCRQRFSPVFKRSPAQVLIEMDKQDENWGRAEEIYKLLRTAYCQFPLLSLDLSTSQELSMAGNSGQNKDEGSSKDQESHNPGMVVLVLAADSFHLQSISNCLNLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R6I4</accession>
    <name>A0A0D2R6I4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G122000</name>
        <name evidence="5" type="ORF">Gorai_007680</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R6I4"/>
    <dbReference type="STRING" id="29730.A0A0D2R6I4"/>
    <dbReference type="Gramene" id="KJB65947">
        <property type="protein sequence ID" value="KJB65947"/>
        <property type="gene ID" value="B456_010G122000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773979"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKSRSCY"/>
    <dbReference type="OrthoDB" id="696276at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF91">
        <property type="entry name" value="PROTEIN OXIDATIVE STRESS 3 LIKE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB65947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0597897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="232" mass="25327" checksum="5E6C550585EAF0FA" modified="2015-04-29" version="1">MEVLMGPTFAIDVAASAAAYTRDRSKDTIPSPCLFIKDDEACPGSDPRSPDLSSDSSSSIGSPGDSDVEEEDDGVVSSGESKGLSFDSLEDSLPIKRGLSNHYVGKSKSFANLSDINSVKELQKVESPFNKRRRLLLANKWSTRSRKSSFYSWQNPNSMPLLALVEDDEDTDNNSHNKQTPSSSPPSLSSSSSEYEKITSTKPKLQQSNLRASFKSQSCLSLTDLHVQVDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RA17</accession>
    <name>A0A0D2RA17_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G062800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BetVI family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB28689.1"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <location>
            <begin position="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009744"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00407"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB28689.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </location>
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            <begin position="48"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB16210.1"/>
        </source>
    </evidence>
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        <source>
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    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
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                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 16"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SBP-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB17520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0581603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="173" mass="20164" checksum="B7232BEB47852D3B" modified="2015-04-29" version="1">MEMAKRACKTTVNWVDDEEEEEQREERMVKIRVVPRERYERMNTFIHYSNSAAISGGGGGCQADECGADLKDAKQYHRRHKVCEPHAKDAFVLVKGIRQRFCQQCSRFHEISKFDGTKRSCRDRLAGHNLRRRKVVQSDQEAENDNSNNKNKASYGKGTDTPMLQQWYQEFTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGY8</accession>
    <name>A0A0D2RGY8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G050000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGY8"/>
    <dbReference type="STRING" id="29730.A0A0D2RGY8"/>
    <dbReference type="Gramene" id="KJB69887">
        <property type="protein sequence ID" value="KJB69887"/>
        <property type="gene ID" value="B456_011G050000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QST1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIVFERT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009875">
        <property type="term" value="P:pollen-pistil interaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044982">
        <property type="entry name" value="AtOFT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37220">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37220:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB69887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="433" mass="49016" checksum="AA91D900673E6A14" modified="2015-04-29" version="1">MDLSSNCKLSRLFACNLTSIICKCLALVTIALFFRAILYHLSSGDVLERDDLDLIPGRSMLSQSDEGIRRNKFLEIAFVRACLTTRMLNRTLLMPSLSASLFCKKINRLQPISFDKVFKFERFNTLCEGFVQLARYSDLKNRTGVYDLRKGSGRKWTVERDLEQLKQSIINGPIDMHEVIRMVGKNPFLWHGHWPVKDYARVFECLVLVDEISKEADKVVSKIRQIGRKLRSEPGMGSSLRPAPYVAVHIRVEIDWMIHCKKLEQRSGVSQICSSKQEIIERVGKIINLEAPIVVYLAVADNLLNDSSLLSGWNKGLVPCEKKNLGVDGIYKKHPYLIQSAIDNEVCSKADIFVGNSFSTFSSHIVFERTQKMMRMGSTSSCKNENEVDVQWPSYAYNIAAGESNGPQKWMTNMSDSSLRVISYDSNAISCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIP8</accession>
    <name>A0A0D2RIP8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G080000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIP8"/>
    <dbReference type="STRING" id="29730.A0A0D2RIP8"/>
    <dbReference type="Gramene" id="KJB70567">
        <property type="protein sequence ID" value="KJB70567"/>
        <property type="gene ID" value="B456_011G080000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778447"/>
    <dbReference type="eggNOG" id="ENOG502S79U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSSNPEY"/>
    <dbReference type="OrthoDB" id="1913905at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34198:SF1">
        <property type="entry name" value="OS01G0104300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34198">
        <property type="entry name" value="OS01G0175100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB70567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="150" mass="16952" checksum="E4FE05D304592597" modified="2015-04-29" version="1">MTLMLTPLYRRRSSLPHLYPQELIVAISLPLRLPKTLKSSMANALAFSFSAPIRASSESLKRPDPSRKNPVSSSSWWTPLFGWPSNPDYLNDSNAGNTSEAKPRCRYTLGSFTEEKARQLRKKTMENSSFHDMMYHSAIASRLASDISEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RL70</accession>
    <name>A0A0D2RL70_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G122400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Reddy U.K."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="entry name" value="BRCT DOMAIN DNA REPAIR PROTEIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR47576:SF2">
        <property type="entry name" value="BRCT DOMAIN DNA REPAIR PROTEIN-RELATED"/>
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    </evidence>
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    <sequence length="174" mass="20023" checksum="139E513F7098D14F" modified="2015-04-29" version="1">MELRWGVLVTLTANKITNRPFLISQSQSQIFSQIGKIHHFCYPFLFQHTKTQRLVRLSESLYTVKGAEDNAACVDELNRLAGSTASENSCLVADFHEAKKLDMIGKPNVWYSGRVLNRSMDSVLSGHTIYIDSDISVELNRLSRLSRLNRLNWLSRLNQLNRLSRLNRLIFNQK</sequence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Reddy U.K."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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        <location>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB21555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="385" mass="42410" checksum="5A6174835D3DAE99" modified="2015-04-29" version="1">MSENREFQLGTIGALSLSVVSSVSIVICNKALISTLGFTFATTLTSWHLLVTFCSLHVALWMKLFEHKPFDARAVMGFGILNGISIGLLNLSLGFNSVGFYQMTKLAIIPCTVLLETLFFRKKFSRNIQLSLAILLLGVGIATVTDLQLNILGSILSLLAVVTTCIAQIMTNTIQKKFKVSSTQLLYQSCPYQALTLFIIGPFLDGLLTNKNVFAFKYTPQVLVRIRSPPPQWVKRNISSTVFLLDFFNVQSLLQFFIVLSCLISVSVNFSTFLVIGKTSPVTYQVLGHLKTCLVLAFGYVLLHDPFSWRNILGILIAVVGMVIYSYYCTVESQQQKASEVSPQLPQVKESESDPLISVDNGSGMLSDGVGPKAPVWNTNKDLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RWF1</accession>
    <name>A0A0D2RWF1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G020900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RWF1"/>
    <dbReference type="Gramene" id="KJB75047">
        <property type="protein sequence ID" value="KJB75047"/>
        <property type="gene ID" value="B456_012G020900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250830" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="55" mass="6482" checksum="1F87347E38A93C4D" modified="2015-04-29" version="1">MKIRNSHRFTFFFVFVAKIGGCNGHSNPKEQLDLDLQICRYFRNLLIELTVFGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RYP1</accession>
    <name>A0A0D2RYP1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">DNA 3'-5' helicase MER3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Protein ROCK-N-ROLLERS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_012G063400</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYP1"/>
    <dbReference type="STRING" id="29730.A0A0D2RYP1"/>
    <dbReference type="Gramene" id="KJB75892">
        <property type="protein sequence ID" value="KJB75892"/>
        <property type="gene ID" value="B456_012G063400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEEVECQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18023">
        <property type="entry name" value="DEXHc_HFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001076">
        <property type="entry name" value="ATP-dependent DNA helicase MER3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000077">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000008">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052247">
        <property type="entry name" value="Meiotic_Crossover_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835:SF3">
        <property type="entry name" value="HELICASE FOR MEIOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47835">
        <property type="entry name" value="HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="34"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="275"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="881"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1108"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1165"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1131"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1170"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00093647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00093653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB75892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1210" mass="135503" checksum="AC91D0729E232FAB" modified="2015-04-29" version="1">MDSYSLKSVFDLPEPFRSIFNFRYFNSLQSECFPVCFLSDVNMVISAPTGSGKTVLFELCILRLLSRFISGDGRFVHIKGTLKTIYIAPSKALVQEKLRDWTQKFGSLGISCLELTGDNDSYSTRNIQEADIILTTPEKFDAVTRYRIKDGGLSFFSDISLLLIDEVHLLNDLRGATLEAIVSRIKMLARNPEMKSSALASVRFLAVSATIPNTEDLAEWLEVPVQGIKRFGEEMRPVKLTTKVFVNAFLAGYASAKNDFLFEKAKHIYNYWSKLIADILMQYSRGKSALVFCSTRSGAQEAAQRLSQIVMTFGYSNPFIKSSEQQERLREASLSCSDKQMQSYILYGVGYHNGGLSLKDRNLIEGLFLNGDVQVLCTTNTLAHGINLPAHTVVIKSTQHFNKEKGLYMEYDRSMILQMCGRAGRPPFEDTGMVIIMTRRETVHLYENLLNGCEMVESQLLSCLTEHLTAEIVQLTISDITKAIEWMKCSYLYVRMKKAFKKGIRREQVEKHMQEICVQNVNELSCHQMIQTDQDGFALKPQEPGRLMTKYYLKFNTMKHIMQAPSNCSLEEVLQIICHAEEIAWIQLRRNEKKILNDLNGDKDGRLRFHVTGDKGKRKKRIQTREEKIFVLANDCLTGDPLVPDLSMTQDANSICSNGARIAKCMKEYFIYKKNYRGALNSSLLAKSLYQKLWDDSPYLLKQLPGIGMVTAKALHSMGIKSFETLAEADPRRIELVTGRKFPFGNHIKESLTSLPPKVDIKIEVSECQRQGKSKLAVTLTRLSSQGVQSTKRHYADMCRMFGYTCSPYSTTTLVSNPLGKMTIKADLVFEEYIGVDLHEKLLLVKESNSNANLKRARKPTQFFAPEEVYVIEDDKAATHKSFAQRPPDSIGSKRESSSMPSFNLLDEELEGEFAAGIENDDCKIITEQSIFDHIREKAKNFPLLTPNNAYSPSSGGLILTRKRSSDQEKSKIRQHILLDPLPESTGHEQVANDHNNYLTGKHHVIAGSSVTINITDESGYLPSEPEAFSFKSLTEEAIFDHIRKKSKHFPVINTPKPVDTDCCICTEEHNSANQPESGNATLGTSKYAMVISEPEPGEVNRDACGTKVGTKTKNNVLQGSSGGANGESAVSPKVSSTKTATSSVQMLSFDISMAKNSKHLADLGSSIQDGRKDKPSPSDSKRQSRSLASTDQAREVGSFLGFQSVFSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S080</accession>
    <name>A0A0D2S080_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G103000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family. Ago subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S080"/>
    <dbReference type="STRING" id="29730.A0A0D2S080"/>
    <dbReference type="Gramene" id="KJB35161">
        <property type="protein sequence ID" value="KJB35161"/>
        <property type="gene ID" value="B456_006G103000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35166">
        <property type="protein sequence ID" value="KJB35166"/>
        <property type="gene ID" value="B456_006G103000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1041">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMNELMF"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000110">
        <property type="entry name" value="Argonaute 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000013">
        <property type="entry name" value="protein argonaute 10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PAZ" evidence="7">
        <location>
            <begin position="337"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="8">
        <location>
            <begin position="621"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB35166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="977" mass="108683" checksum="14D2D653414A4AAF" modified="2015-04-29" version="1">MSGRGGGERGSGRGGGRRGRGQGRGRGQPSQSSSRGGGGRARGRGSSGSTATYNPPPPQMAPAQPPPQMAVATPVPPSGAPFSHPSSSSGVGSLSREVSEKLTMEPVAVTTAPPLPPSSSKAIRFPPRPGFGTVGTKCVVRANHFLVDVANADLHHYDVTITPEVTAKKVNRAIMKQLIDVYKESHLGRRCPAYDGRKSLYTAGPLPFESKELVIKLPEEDRSAGSSRPARKERQFKVAIKLASKPDLHYLREFLSRKHFECPQEAIQVLDVVLRAKPSQTYTEVGRSFFHTSLGPRGELGNGIEYWSGYYQSLRPTQMGLSLNIDVSARSFYEPILVSEFVAKHFRRSNLSKPLSDQDRIKVKKALKGVRVKLIYMDYAKTCKIIGVSRDPISQLTFTHDDKRTNVSVVKYFREKYNVVLKYPSLPALQSGSEARPVYLPMELCSIVEGQRYTKKLNEQQVRSLLRATCQRPNIREGNITKMVQVNNFEVEELVTKEFGMHVRKELALINARVLNPPVLKYHDSGRDKIVNPSCGQWNMINKKMVNGGKVDFWSCVNFSSEYRNMSEDFCAGLVNMCNSKGMVFRQTPSIAMRSARADRIDQTLMDVYKESAGLNKPLKLLIIILPDQTGSYGKIKRICETELGIVSQCCKPAQASKFSNQYFENVALKINAKVGGRNTVLNDAVLRRIPLVTDVPTIIFGADVTHPPPGEDSSSSIAAVVASMDWPEVTKYRGIVSAQTHRVEIIEDLYKQTRDPQKGLVEGGMVRELLLAFYRSTKQKPSRIIFYRDGVSEGQFSQVLLYEMDAIRKACSSLQEGYMPRVTFVVVQKRHHTRLFPTDRNKTDRSGNILPGTVVDTSICHPTEFDFYLNSHAGIQGTSKPTHYHVLLDENGFSADILQVLTNNLCYTYARCTKSVSIVPPAYYAHLAAYRARYYIEDEMSDSGSTGGGRKPKDKVVEVRPLPSIKDNVKEVMFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S102</accession>
    <name>A0A0D2S102_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G144400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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            <taxon>Tracheophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">8</strain>
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        </source>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S749"/>
    <dbReference type="STRING" id="29730.A0A0D2S749"/>
    <dbReference type="Gramene" id="KJB27105">
        <property type="protein sequence ID" value="KJB27105"/>
        <property type="gene ID" value="B456_004G278200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792873"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IRCWKLD"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016131">
        <property type="term" value="P:brassinosteroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20639">
        <property type="entry name" value="CYP734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000029">
        <property type="entry name" value="Cytochrome P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF224">
        <property type="entry name" value="CYTOCHROME P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB27105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="517" mass="59202" checksum="2D5B1294CFAFD448" modified="2015-04-29" version="1">MEVMLQWPSKIVFITSMALLMVVMMMKVVVLLWWKPKKIESHFLKQGIKGPPYHFFIGNVKELVGMMLKASATPMPDFSHNILPRVLSFYHHWKKIYGTPFIVWFGPTVRVTVSDPDLIKEIFISKSELYEKNEAHPLIKQLEGNGLLSLKGQKWAHHRKIITPTFHMENLKLLVPVMTQRMTDMLDKWSAMSANGSRDVEIDVCEWFQTLTEDIITRTVFGTSYEDGKAIFCLQAQQMVLAAETFQKVFIPGYRFMPTRRNIRCWKLDKEIRKSLMKLIESRKSENRRREDGAKDLLGLMIESSYSSPDMSVDDIIEECKSFFFAGKQTTSNLLTWTTVLLAMHPQWQVQARDEVLKVCGSRDLPTKDDVVKLKTLTMILNESLRLYPPTIATIRRAKSDAELGGYMIPRGTELLIPILAVHHDQAIWGNDANEFNPGRFSEGVARAAKHPIGFIPFGLGVRTCIGQNLAVLQAKLALSIILQRFTFRLAPTYQHAPTVLMLLYPQYGAPIIFQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7F2</accession>
    <name>A0A0D2S7F2_GOSRA</name>
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        <submittedName>
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        </submittedName>
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    <gene>
        <name evidence="2" type="ORF">B456_009G244000</name>
        <name evidence="3" type="ORF">Gorai_012620</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7F2"/>
    <dbReference type="Gramene" id="KJB59178">
        <property type="protein sequence ID" value="KJB59178"/>
        <property type="gene ID" value="B456_009G244000"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QR6N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIYRPFM"/>
    <dbReference type="OrthoDB" id="2446218at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38542">
        <property type="entry name" value="OS04G0450500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38542:SF2">
        <property type="entry name" value="REPLICATION FACTOR A C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB59178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0595763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="435" mass="49221" checksum="7AF4C5F22C10258E" modified="2015-04-29" version="1">MTSSYGPLINLSEASNHMGHFVQLLVFVHRSTPVQYKLSKGGEIIRTDIQVGDDTRPFFSVSLWKKELRSIFAAGDIVLLRNVKITTFRDVFEARTVDWSSLLRLVHPCQSLVSKSAIELVAECRMGIVVKEKLSQVIEWVQRTGYIAIDNIEPNDCQKRRLSRNWKVPEPNKFRECPSLSEVLCLNSHCKAIFSASVGEIFLPITWRPIGESENENMFISRRLYRSADNNLAEDLICTGCRLCGSPLHQEQGSIVGTNSVPLYCEKSSDRLHAVSLIYRPFMLYLWDESEHMPLLVKNNAAEKLFGNIKAERVYLCYKEYKRDITLNPGCIAENGSHGCGTRIRSSPKAAGASDAEHCSSDAHEKQEGMRNPQCNKNINLFQIWLVVLKLLLQRGKNSPLKFEVAVNASLDTENGRFEMITVSTPCFKTIRCLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S9N3</accession>
    <name>A0A0D2S9N3_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deubiquitinating enzyme MINDY-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_009G285100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S9N3"/>
    <dbReference type="STRING" id="29730.A0A0D2S9N3"/>
    <dbReference type="Gramene" id="KJB59973">
        <property type="protein sequence ID" value="KJB59973"/>
        <property type="gene ID" value="B456_009G285100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770244"/>
    <dbReference type="eggNOG" id="KOG2871">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WTRWPKT"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Deubiquitinating enzyme MINDY-3/4 conserved" evidence="8">
        <location>
            <begin position="109"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB59973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="610" mass="66405" checksum="28DFF6E9D1648A89" modified="2015-04-29" version="1">MADQQEEEDLRMALRMSMQNSPPEPKRSKPREAANLATTTPEESRRLQRELMAAAAEKRMLATGKSVPASGSPLKSDSGGDIGTKEMEIKAKEVKLGNELSEKEAYQLFFMVFGNGVSKDILAQWSNQGIRFSPDPETSMILVQHEGGPCGVLAAIQAFVLKHLLFCPDDLVKAAQSTPQNSTPRRLSKNQYVASNNFAAFTENAKARALVKSMGEILFLCGNNKRAVIATLSSIGDGVEESEDSLTDVIIAQALEGLSIESASDLHEVLRVETYTTPASAYKRLEAIIPVFQSRMGALLFLISALLSRGLDCVQADRDDPSLPLVTAPFGHASQEIVNLLLCGQAVPNVFDGRMDLGGGMFLKGVSTNVEVGFLTLLESLNFCKVGQNLKCPKWPIWVVGSESHYTVLFALDTAVQDENELEARESQIRKAFDAQDQSGGGGFISVEGFHQVLRETNIRLPSEKLDSLCGSGFIVWSEFWQVILDLDKSLGGLKDSTGQMGQKIFDLYHFNGIAKSDLNGSQFSSGGETPMQRPRLTKLRVSVPPRWTPEEFMADVAVLPSGSAGAQPSGKDTEVAKPEPSQHAPLVDCIRTRWPRAVCNWVGDPPSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAD4</accession>
    <name>A0A0D2SAD4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G032800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAD4"/>
    <dbReference type="STRING" id="29730.A0A0D2SAD4"/>
    <dbReference type="Gramene" id="KJB28185">
        <property type="protein sequence ID" value="KJB28185"/>
        <property type="gene ID" value="B456_005G032800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796537"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPFHTGP"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF226">
        <property type="entry name" value="CYTOCHROME P450 CYP749A22-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
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                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Conover J.L."/>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="74" mass="8641" checksum="9D18251F6E548321" modified="2015-04-29" version="1">MDDYNCKRSGQIPAFGDWDHANEFPITQYFESAREAGLIRFNSSSAKPKPYLTVDLKTKHPRNHVPVRKDERFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <location>
            <begin position="94"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB82797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="188" mass="21453" checksum="65FD2556375DAF49" modified="2015-04-29" version="1" fragment="single">PSNYITGFQVLIEAVEQLIQDKPSEKMTSQQLVWLYTIMLTASAVKIVLWFYCRSSGSKIVRAYAKDHYFDVVTNLVGLIAAVLVSLVGQSAPPEVLQKLAYLVLRHHPQIKRVDTVRAYTFGILFFVEVDIELPEDLPLKETHAIGESLQIKIEQLQEVERAFVHLDFECRHKPEHSVLIRLPTTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKE5</accession>
    <name>A0A0D2SKE5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_007G267100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SKE5"/>
    <dbReference type="STRING" id="29730.A0A0D2SKE5"/>
    <dbReference type="Gramene" id="KJB44694">
        <property type="protein sequence ID" value="KJB44694"/>
        <property type="gene ID" value="B456_007G267100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804526"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGDPDYS"/>
    <dbReference type="OrthoDB" id="1918322at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000162">
        <property type="entry name" value="Adenine nucleotide alpha hydrolase-like domain kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000161">
        <property type="entry name" value="Wall-associated receptor kinase-like 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008">
        <property type="entry name" value="LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-LIKE 1.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008:SF2">
        <property type="entry name" value="LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-LIKE 1.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267323" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="29"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="343"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB44694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="636" mass="71044" checksum="5DBF17C7E76E7260" modified="2015-04-29" version="1">MVSITFQANPVFVYVFFLLFLGSHYCFSQKTCPRCGSMVVPYPLSTHPSCGDPSYSLRCDSQTHKLYFDALNGSSYPVIRIMASVYRMVVQPSPWLTGKCVTQDMGVSEGIWLNQTLPFNITSSNTIFLLNCSPRLLMSPLNCTPTSLCHHYLESSGHVEAKRALQCAEGVNPCCTFVAGGMPSAYKIRLHSSGCKAFRSILHLDPEKAAYEWEEGLEIEWRPPLEPVCKSQLDCFGASNCSPTSSNGLSRCLCNKGYKWDTVVGSCLRKKKKSRVSLKVSIGVISFFTLAMAIVAITSRKRWRNYNQAKLMKAREDMLKSSNGGKPAKIFRLKEVKKMTNDFSRNRFLGSGGFGEVYKGELPNGDIVAVKSAKVGNIKSTQQVLNEVGILSQVNHKNLVRLLGCCVEAEQPLMIYEYISNGTLSDHLHGKYSTFLDWKTRLKIALQTAEALAYLHSAAYTPIYHRDVKSANILLDYEFNAKVSDFGLSRLASPGLSHVSTCAQGTLGYMDPEYYRNYQLTDKSDVYSYGVVLLELLTSQRAIDFSRDQDDVNLAIYVNQRATNGAIMEVVDQQLLKDPSADMLKSFKLFSDLAFACLREKKSGRPAMKDVVQELHCIIQIIDQENVSKELSQEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SL23</accession>
    <name>A0A0D2SL23_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G161000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SL23"/>
    <dbReference type="STRING" id="29730.A0A0D2SL23"/>
    <dbReference type="Gramene" id="KJB42626">
        <property type="protein sequence ID" value="KJB42626"/>
        <property type="gene ID" value="B456_007G161000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB42627">
        <property type="protein sequence ID" value="KJB42627"/>
        <property type="gene ID" value="B456_007G161000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803358"/>
    <dbReference type="eggNOG" id="ENOG502QQAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDYKQGN"/>
    <dbReference type="OrthoDB" id="9985979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007877">
        <property type="entry name" value="DUF707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210:SF8">
        <property type="entry name" value="DUF707 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31210">
        <property type="entry name" value="OS06G0731900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05212">
        <property type="entry name" value="DUF707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB42626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="44416" checksum="B51474632AE2F18A" modified="2015-04-29" version="1">MKRRMSTSISTKTEPKRQRLFTHCFLPMILLLSAAFFIGSAFIITDYKEKILGWGSVMVLQYSRSKMCETQCRAYGSEALPRGIISETSDLEMRPLWGAQNKKKPKLSMNLLAIAVGIKQKENVNKMVKKFLESDFVVMLFHYDGIVDQWKDLEWNDRAIHVSAVNQTKWWFAKRFLHPDIVSEYGYIFLWDEDLGVDHFNAKRYLSIIKKEGLEISQPALDPEKSELHHPITARDKNSTVHRRTYKVIGRTKCNENNTGPPCTGFVEMMAPVFSRASWRCSWHMIQSDLVFGWGLDFQLGYCAQGDRTQKIGIVDSEYLIHDALPTLGGSAENKVSSPSSESGGRSEVKKQSYIELEIFKSRWKRAVNQDNCWSDPFEQSTKKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLG4</accession>
    <name>A0A0D2SLG4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stomagen C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_N003800</name>
        <name evidence="4" type="ORF">Gorai_002043</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000073">
        <property type="protein sequence ID" value="MBA0603742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLG4"/>
    <dbReference type="STRING" id="29730.A0A0D2SLG4"/>
    <dbReference type="Gramene" id="KJB84097">
        <property type="protein sequence ID" value="KJB84097"/>
        <property type="gene ID" value="B456_N003800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784657"/>
    <dbReference type="eggNOG" id="ENOG502S4I2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KCVCHNP"/>
    <dbReference type="OrthoDB" id="1893550at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000123">
        <property type="term" value="P:positive regulation of stomatal complex development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22743">
        <property type="entry name" value="stomagen-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.390:FF:000001">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-like protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.390">
        <property type="entry name" value="Stomagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031753">
        <property type="entry name" value="Stomagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044858">
        <property type="entry name" value="Stomagen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038572">
        <property type="entry name" value="Stomagen_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37239">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37239:SF1">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16851">
        <property type="entry name" value="Stomagen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220379" description="Stomagen C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Stomagen C-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB84097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0603742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="110" mass="12377" checksum="7D3A2C4519D76168" modified="2015-04-29" version="1">MGNIKISHLLLILFTFFLAAYVIQGSRTQVLLPCQHQASHSPPLNLQLRASNEAEKKKNSRRLMIGSTAPTCTYNECRGCKYKCRAEQVPVEGNDPINSAYHYKCVCHNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXM2</accession>
    <name>A0A0D2SXM2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G228100</name>
        <name evidence="5" type="ORF">Gorai_008337</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXM2"/>
    <dbReference type="Gramene" id="KJB68142">
        <property type="protein sequence ID" value="KJB68142"/>
        <property type="gene ID" value="B456_010G228100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68143">
        <property type="protein sequence ID" value="KJB68143"/>
        <property type="gene ID" value="B456_010G228100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772981"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKCKPTS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000530">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At1g74850, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="299"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="440"/>
            <end position="470"/>
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    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="475"/>
            <end position="509"/>
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    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="580"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB68143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0598580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="638" mass="71887" checksum="FC68765722CD45CD" modified="2015-04-29" version="1">MKTIMLPAFALRRCISTSACLCQRIKQTDNEIVQMFRLPVPMRDWAFNRNFPKKNAYARTLDKRFIRILKIFKWGPDAEKALEVLKLKVDHQLVREVLMIDVEINVKIQFFKWAGKRRNFEHDSTTYLALIHCLDEAGLVGEMWKTIQDMVRSTCVVGPAELSEIVRILGKAKMVNKALSIFYQIKSRKCKPTASTYNAIILMLMQEGHHEKVHELYNEMCNEGNCLPDTITYTALMSTFSKLGRHDSAIRLFEEMKENGLQPTPKIYTTLIEIYFKLGRTESALGLVQEMTGNGCSPTVFTYTELIKGLGKAGRVEDAYGIFMNMLKEGGKPDVVLINNMINILGKVGRLEDALKLFNEMKSWQCAPNVVTYNTIIKALFDNKAPISETSSWFEKMKADGVVPSSFTYSILIDGFCKANRVEKALLFLEEMDEKGFPPCPAAYCSLINSLGKAKRYEAASELFQELKENCGHSSARVYAVMIKLFGKCGHLSKAVDLFNEMKKLGCNPDVYTYNALMSGMIRAGMIDEAHSLLRTMEENGCTPDLNSHNIILNGLARTGGPKRAIEMLTKMKNLKIKPDAVSYNTVLGCLSRAGMFEEAAKLMKEMKASGFEYDLITYSSILEAVGKADEDNNLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SY53</accession>
    <name>A0A0D2SY53_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_010G239600</name>
        <name evidence="19" type="ORF">Gorai_008403</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the two pore domain potassium channel (TC 1.A.1.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SY53"/>
    <dbReference type="SMR" id="A0A0D2SY53"/>
    <dbReference type="Gramene" id="KJB68338">
        <property type="protein sequence ID" value="KJB68338"/>
        <property type="gene ID" value="B456_010G239600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772266"/>
    <dbReference type="eggNOG" id="KOG1418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEGRIFA"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000102">
        <property type="entry name" value="Two-pore potassium channel 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF282">
        <property type="entry name" value="TWO-PORE POTASSIUM CHANNEL 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="113"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="17">
        <location>
            <begin position="240"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB68338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0598647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="393" mass="43982" checksum="7A0EC6E08C7C630A" modified="2015-04-29" version="1">MENDQLLSYLSPRKKLRPPPVFLPSIVESLNSPKPPLPPSSSSDTILNLQESLLLQNQQNSPATRSDPNLTWRKINLHRCKTAPAMAVLMDAINPSIPKPKFGSESIVRQACILLILYLSLGVAIYWFNRHHFVGPKTNPVVDALYFCIVTMCTIGFGDITPNSNATKLFSILFVLVGFGFIDILLSGMVSYVLDLQENYLLKTVQHDGDKRDLATSYIIDVKKGRMRIRLKVGLALGVVVLCIGIGVGVMHFVEHLEWLDSFYLSVMSVTTVGYGDRAFKTMPGRLFAAIWLLVSTVAVARAFLYLAEARVDKRHRRMAKWVLGQDMTVSQFLAADIDNNGYVSKSEFVIYKLKELGKVSEKDIMQISQKFDRLDSGNCGRICLADLKDSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZ08</accession>
    <name>A0A0D2SZ08_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA uridylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_008G115100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14785"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17348"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173116"/>
            <dbReference type="EC" id="2.7.7.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.52" evidence="5"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SZ08"/>
    <dbReference type="STRING" id="29730.A0A0D2SZ08"/>
    <dbReference type="Gramene" id="KJB49359">
        <property type="protein sequence ID" value="KJB49359"/>
        <property type="gene ID" value="B456_008G115100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763809"/>
    <dbReference type="eggNOG" id="KOG2277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEWPHAK"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000018">
        <property type="entry name" value="Terminal uridylyltransferase cid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000067">
        <property type="entry name" value="Terminal uridylyltransferase cid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="13">
        <location>
            <begin position="375"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="12">
        <location>
            <begin position="594"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="193"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB49359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="694" mass="78575" checksum="05B8B7F14F96A770" modified="2015-04-29" version="1">MPGGGGDAPREPTANGGEFLLSLLQNPPQQQQQQRQSPLLSRVTPMLIPQPLQQQQLQQQPLPLDPAVAAVGRVFPLQSPSWPSNGRDLSTPWAQTISSPLVPNFLAFPQNPWSSSGNQFVGNRGDLNDDLRRLGFPSVDNNSNNLIQQKHPEQQQQQQQQKLVFGSFPSDIQILQKPEGLLNGNLFDKSNLDLSKPANSSPYAFQHQSERGKQQQHHVGNYRETLRPPPGFSGKPRGGGGSRDFGARRNHLEHNVDKLRAEYSQLSNDNEMGLRGQLDHPGPPAGSNLQSGTDIKESLMELHRFGGGQVDEVGERIVESLLIEEESEDKNDKKHHRHEKESRLDNRGQRLLSQRVRMLKRQMECRSDIHRLNAPLLAIYESLNPPKEEKTKQQQLLASLEKLVWKEWPQAKLFLYGSCANGFGVSRSDIDICLALNEDINNKSEILLKLADILQSDNLQNVQALTRARVPIVKLMDPVTGISCDICINNVLAVVNTKLLRDYAQIDARLRQLAFIVKHWAKSRGVNETYRGTLSSYAYVLMCIHFLQQRRPAILPCLQGMEKTYNVTVDNIECAYFDQIEKLLNFGSSNKETVAQLVWGFFNYWAYGHDYANSVISVRTGSIISKQEKDWTRRIGNDRHLICIEDPFETSHDLGRVVDKFSIRVLREEFERAADIMQFDPNPCVKLFEPYVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2Q3</accession>
    <name>A0A0D2T2Q3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G087000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2Q3"/>
    <dbReference type="STRING" id="29730.A0A0D2T2Q3"/>
    <dbReference type="Gramene" id="KJB48781">
        <property type="protein sequence ID" value="KJB48781"/>
        <property type="gene ID" value="B456_008G087000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S846">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQVRYKA"/>
    <dbReference type="OrthoDB" id="614712at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF7">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027160150" description="Epidermal patterning factor-like protein" evidence="7">
        <location>
            <begin position="32"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB48781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="128" mass="14722" checksum="A668097B262EFB18" modified="2015-04-29" version="1">MFYSHGFVLCQRHRYLFLIFLLILSTTQVRYKAEGRPNPKSDTFSKKVNEEKKILSAQIGSRPPRCDRRCSSCGHCEAIQVPTNPQVRNGNKNFSTLLFGVAYARRVDNSNYKPMSWKCKCGNVIFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2Q4</accession>
    <name>A0A0D2T2Q4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_006G224700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2Q4"/>
    <dbReference type="STRING" id="29730.A0A0D2T2Q4"/>
    <dbReference type="Gramene" id="KJB37880">
        <property type="protein sequence ID" value="KJB37880"/>
        <property type="gene ID" value="B456_006G224700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRYMQKK"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251425" description="glucan endo-1,3-beta-D-glucosidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="13">
        <location>
            <begin position="372"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB37880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="462" mass="50650" checksum="7206A2CBEB3C29C7" modified="2015-04-29" version="1">MALLPLLFSSLLVVSLAEMSGKIGVNYGREGDNLPSPYESIQIMKSIKVGQIKLNDSNPEILTLLSGTKIHVAVTVPNDDIIQIGSNDSMAEQWVRNNILPHYPDTMIRFVLVGDRVVNSNMDVNGTMEQSLVPAMRGIKSALTAHGVKNVKVSTTLGMDVVQTRFPPSNSTFQSDISDSVMPKLLKFVNGTKSVVFVDVYPYFAWSANPTNISLDFALFGGNITHTDPGSGLVYTNLLDQMLDSVTFAIEKLGFRNIRLAISRTGWPTAGDIDQVGANIYNAATYNRNLIRKMTSKQPLGSPKSPGLIIPTFISSLYDENRKIGPETERHWGMLHTNGTPVYEIDLTGNRKISEYKPLPPAVNNVPYKGKLWCEVAPWVNEMSLPAALSNVCSIDNETCAALAPGKDCYEPVSVVWHASYAFSSYWAKFRSQGAICSFNGLARETTVDPSRGRCNFPSVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T4N8</accession>
    <name>A0A0D2T4N8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G218400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T4N8"/>
    <dbReference type="STRING" id="29730.A0A0D2T4N8"/>
    <dbReference type="Gramene" id="KJB51479">
        <property type="protein sequence ID" value="KJB51479"/>
        <property type="gene ID" value="B456_008G218400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB51482">
        <property type="protein sequence ID" value="KJB51482"/>
        <property type="gene ID" value="B456_008G218400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764921"/>
    <dbReference type="OMA" id="RNVNTRH"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000018">
        <property type="entry name" value="ALKylated DNA repair protein AlkB homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB51479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="37948" checksum="0129093088120608" modified="2015-04-29" version="1">MVMPRFVRPKEGDSESSPDLYVANCGPAVGLQFDTIASAFSSFGEVKGVYAADESGARVIVSFLEPASAHSAFIALNDRPCPHLGGRSLHIRHSILQPPSSRGMASVPVSLNASDLNIPGLYLFHDFISAVEEEQLLQAVDTGSWISLSKRRVQHYGYKFCYDTRNVDTKQHLGALPSFVSFILERISLSPDIPEKLDLDQLTVNEYPPGVGLSPHIDTHSAFEGLIFSLSLAGPCIMEFRRYTAGSWAPKTASISDTEVENPNSCSEVSRKAIYLPPRSMLLLSGEARCAWHHYIPHHKIDKVNETMIRRGSRRVSFTFRKVRRGPCQCEFPQYCDSQSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T6L6</accession>
    <name>A0A0D2T6L6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF659 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G116500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T6L6"/>
    <dbReference type="STRING" id="29730.A0A0D2T6L6"/>
    <dbReference type="Gramene" id="KJB71318">
        <property type="protein sequence ID" value="KJB71318"/>
        <property type="gene ID" value="B456_011G116500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RJJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MENANAM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007021">
        <property type="entry name" value="DUF659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32166:SF81">
        <property type="entry name" value="OS06G0658400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32166">
        <property type="entry name" value="OSJNBA0013A04.12 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04937">
        <property type="entry name" value="DUF659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF659" evidence="2">
        <location>
            <begin position="139"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB71318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="600" mass="69434" checksum="80FA298C1DAC132D" modified="2015-04-29" version="1">MTSQSGSGSVDSSDNVTNASVSQDDISKTHFWRYVTKLPKTVERVTLQHLAEMQKIVEDVKLKSQQKIVSLLPIYSFGPNTTLLQRHSLDSKRRKCPLEQSFNLAARENLDSEIARMFYSGGLPFHLARNPHYVNAFTLASKNLISETSNIERLLQPIKGMWREKGISLICDGWTDAQRQPLINFMVVSEGGVVFLKAVNYEKEYKDKFYVTTLIKDAISEVGAQNVVQVITENASICKDVGSLVETQHPHIFWTPCVVHTINLALKNICAAKNIEKNEVTYDVLCWINNVGDDAIFIRNFIMNHSMRLAIFNSFVPLKLLTVVDTLFASTIVMLKRFKLIKRGLQNMVIGDEWSTYREDDISKAYLVKEKILDDLWCDKVDYILTFTEPINDMLRIMDTNKPTLHLVYEMWDEMIEKVNTSIYKHERKKGDKRSTFYEVVYDILIDRWTKSSTPLHCMAHSLNPSDWLNEVPNHLPPHKDVEISEERNKCLRRYFPSTEERNMRNWSTYSFIHSMRRNKINPQCTQDLVFVHTNLRLLSRKTLHYKRENKMWDIRGDVFDSFEGVGILGVASLSLDEPDMEMVIFANEEEDMENANAMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8U8</accession>
    <name>A0A0D2T8U8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G044400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T8U8"/>
    <dbReference type="STRING" id="29730.A0A0D2T8U8"/>
    <dbReference type="Gramene" id="KJB40050">
        <property type="protein sequence ID" value="KJB40050"/>
        <property type="gene ID" value="B456_007G044400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802127"/>
    <dbReference type="eggNOG" id="ENOG502R2X6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCRPNQA"/>
    <dbReference type="OrthoDB" id="1928604at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18919">
        <property type="entry name" value="bHLH_AtBPE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000002">
        <property type="entry name" value="Basic helix-loop-helix transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024097">
        <property type="entry name" value="bHLH_ZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565:SF431">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="170"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="52"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB40050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="333" mass="37300" checksum="75F59F8174242638" modified="2015-04-29" version="1">MATYSFQSHPFLLDSIFLPNTSTTKVSGLVEEGNIINPNCFPQFYQDSPVGSMLHQSSCLDHSSNEPSTVTKKQSTEDDSSTAVDKLESGEQVTQKKRTRNGTTSNSAQFKGAKEGKTKKQKKCNDGLKNEKKGCNSKADKKDQEKSTEQPPTGYIHVRARRGQATDSHSLAERVRREKISERMKTLQRLVPGCDKVTGKALMLDEIINYVQSLQNQVEFLSMKLASLSPTFYDFGVDLETLMIRPERVSSTETSPLPMPCPQQCNPIQTTIAPSHINYPLLDVSTALFLQQGLRPNLFSHSQDNGSVLWDVEDQRQKIFNSSQLNDNLCFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCW3</accession>
    <name>A0A0D2TCW3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial adenine nucleotide transporter ADNT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G106400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCW3"/>
    <dbReference type="STRING" id="29730.A0A0D2TCW3"/>
    <dbReference type="Gramene" id="KJB41485">
        <property type="protein sequence ID" value="KJB41485"/>
        <property type="gene ID" value="B456_007G106400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802779"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTFRREV"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000116">
        <property type="entry name" value="Mitochondrial substrate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="38"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="141"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB41485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38360" checksum="F54A8510781F20C1" modified="2015-04-29" version="1">MASEDVKTSESAVSTIVNLAEEAKLAREGVKAPSYAILSICKSLAAGGVAGGVSRTAVAPLERLKILLQVQNPHSIKYNGTIQGLKYIWRTEGFRGLFKGNGTNCARIVPNSAVKFFSYEQASKGILYLYQRQTGNEDAQLTPLLRLGAGACAGIIAMSATYPMDMVRGRITVQTESSPYQYRGMFHALSTVLREEGPRALYKGWLPSVIGVIPYVGLNFSVYESLKDWLIKSRPFGLVEDSELSVTTRLACGAAAGTVGQTVAYPLDVIRRRMQMVGWKDAASVVSGDGRNKASLEYTGMIDAFRKTVRHEGFGALYKGLVPNSVKVVPSIAIAFVSYEVVKDILGVEIRISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGA4</accession>
    <name>A0A0D2TGA4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G166600</name>
        <name evidence="12" type="ORF">Gorai_018893</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGA4"/>
    <dbReference type="STRING" id="29730.A0A0D2TGA4"/>
    <dbReference type="Gramene" id="KJB42745">
        <property type="protein sequence ID" value="KJB42745"/>
        <property type="gene ID" value="B456_007G166600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803419"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12458">
        <property type="entry name" value="RRM_AtC3H46_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000678">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 53-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056276">
        <property type="entry name" value="AtC3H46-like_PABC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034365">
        <property type="entry name" value="AtC3H46-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24009">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24009:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23182">
        <property type="entry name" value="PABC_AtC3H46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="HTH OST-type" evidence="10">
        <location>
            <begin position="233"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="339"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0590177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64781" checksum="59DCAD0C235D2773" modified="2015-04-29" version="1">MDFSESTKIVYNRIQKLEPENVSKIIGYLLLQDNGDLDMIRLAFSPDALLHSLIHKAKSQLSLNKPPVSQVSPTPVVDFPMQLTPFSRAVLTQRAAATPFWDPSVTAAEQHVNSLEFTPPGYSDAVAEDHSFQSQMHFLNMEDQLEPPNSVGSEFSSSYYYSEPALGARTSRRSPSLPEFPVKICHYFNKGFCKHGNNCRYFHGQPMPESFSQLFSSSSNEAGNEDNVVSPGTLEKLELELTELLKARRGLPVSIASLPTLYYEKYGRTLQAEGYLTESQRHGKAGYSLTKLLARLKSSIRLIDRPHGQHAVILAEDAPKYLEYASERNDPGAIVAGSRQIYLTFPAESTFTEQDVSHYFNKFGPVQDVRIPCQQKRMFGFVTFVYAETVKQILAKGNPHFVCGARVLVKPYREKSRLVDRKYPEKLQHPPMYYGPHFIDGDSELQSMPRVCDNSRPFRKQLIDDREQTLEFEGRRFSELQLAPKQYMTNHFYFGYSMDELKHTDVVACADQAVDFPTAERFNYLLDVLNTGSTSEDKVKHISTNYNDPDSSQGLNLPESPFASPIGSGISTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TLY6</accession>
    <name>A0A0D2TLY6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FRIGIDA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G263300</name>
        <name evidence="7" type="ORF">Gorai_019560</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Frigida family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2TLY6"/>
    <dbReference type="Gramene" id="KJB44650">
        <property type="protein sequence ID" value="KJB44650"/>
        <property type="gene ID" value="B456_007G263300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804490"/>
    <dbReference type="eggNOG" id="ENOG502QR8U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1166041at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012474">
        <property type="entry name" value="Frigida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791:SF33">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07899">
        <property type="entry name" value="Frigida"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1208"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1242"/>
            <end position="1257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB44650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0590871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1309" mass="146478" checksum="4BFF373E739614C1" modified="2015-04-29" version="1">MNDIDDISADLILLESQWKGLVNTLEKLQCEGGSSSVSLLALQCRKIQELSSSIQSGIRTRFDVLRYKEIEIGNRLKDLELRENELGKRSKFKLDEVLIGEGSSLLGLKFIVSDDGERLLMFLNAHENEHGKLADEVYNVLKMSNNPGKLVWQAVKRVFMEQRNVGVETNVERRSCLVLLEALMRARPGIKKGVQKQAIFAAKAWKIKKGMQGEDDMEILLFLMLVGAFGLLGQFKSNEIRSLFKRVAQHKQASLLGHSLGLFEKAAPDSCILHSQVKMEQLGEVSNVMSEAIDDTKINSSSPSSADLRFIASTDADRLLMFLTEHENDDRIGNDVYNALKTSGKPAKLVLNVVKAGISERANIGVQRGVVKNSCVILLEQLMRLRPVISQKLRKNALGVAQQWKGNIKDNGIYDKEILVFLMLVGAYGLTSEFNIKEIESLFKSVSLHKQAPILSPILGFVDQTFVRDIYHSQVKIEQSEADNFQLDSSIPSEPKFEQHVDSSSTRSWPELKFLSINMNARGLTLFLSERVEDHNLMRGEISNALLLAPDPAKLVLDASSFFYRSKSGDGFKGIALSNARKSCILLLEQLVTCSVQIEPHVNEEALKLAVEWKGRMDEKYPQGVMAYGFLQFIITYRLKSSYNVDELLFLLVTGSEYRQSPDLCLALGLADKTSILIETLINKNLRLEAITYICAFDLADKFPPALLLNAHLKYSKMRKYRKGKKSNMKLNETIDQEIAIMRRVIRCIADHKLESLYPPQDLENYILHLERQKELGNDTAQREKQKAEKKKDLPIPLTKAKMQQDGELNRPCINMSAEAAPSLFAGAGGNLHLKPSPLEQPIRPIADQSVPCSLSVSAAFCGDTSSFNWQYGCEIGDPWSLEHFTSTRAVNKAAPESSIHHAQVMIDQCQSDNFHSDAFVPSEAKFKHYTTCSSTSYGVDLQSYSTSMDAMGLILFLCKHVEDHNFMRCEISDALQLAPDPARLVLDAISTFNIPELSNTHEKKWNGSNSGNLCHVRKSCILLLEQLRTFPFQIDPHVNEEVLKLAFDWKERALKGVVAYGFLQLIVTYSLIFAYEADELFGLLVIASEYHQSPALCLALGLTDKIHVLIETLVKKNLRLEAIGYICALDLVDKFPPAQILKAHLEYLMQSVHQEAQKSHWKPRQIRDKKKGAVGKVIGCIADHKLEKLFPRKKLENYIRHLEKQNADANVAARKEKQKTGRKKTPKAPSANTKPQHESGTKLPSPTTSSTTGSTTKLSPLQLLETFFADQAVSHGLRDSATFSATSNLVSDNQQTDVAAINDDGNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQI8</accession>
    <name>A0A0D2TQI8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G239100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQI8"/>
    <dbReference type="Gramene" id="KJB59094">
        <property type="protein sequence ID" value="KJB59094"/>
        <property type="gene ID" value="B456_009G239100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769577"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YSFPQHI"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000001">
        <property type="entry name" value="probable beta-D-xylosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000004">
        <property type="entry name" value="probable beta-D-xylosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE III-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268038" description="Fibronectin type III-like domain-containing protein" evidence="9">
        <location>
            <begin position="42"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="10">
        <location>
            <begin position="715"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB59094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="831" mass="91807" checksum="4734086B11039402" modified="2015-04-29" version="1">MIVRYMLRINQNPMRHLSTRKMKLLNLSLLIHLCSLLLVSTQPTNQPPFSCDSTDPLTKSYKFCKTTLPINRRVEDLVSRLTLDEKISQLVNTAAAIPRLGIPGYEWWSEALHGVAFVANISQGIRFNGTIRSATSFPQVILTAASFDPYLWYRIGQAIGIEARGVYNAGQARGMTFWTPNINIFRDPRWGRGQETPGEDPLVTGKYAVSFVRGIQGDSFEGGKLGESLQVSACCKHFTAYDLDNWKGINRFVFDANVTLQDLADTYQPPFQSCIEKGKASGVMCAYNRINGVPNCADYNLLSKTARGQWGFNGYITSDCDAVSIIYDEQGYVKEPEDAVADVLTAGMDLDCGEYLKNYTGSAIEKKKVAVSDIDRALHNLFSIRMRLGLFNGNPAKQPFGNIGSDQVCSQEHLNLALEAARNGIVLLKNDNRLLPLAKTEITSLAVIGPNANSSETLVGNYAGPPCNPVTPLQGLQSYVKNINYHPGCSTVNCSSDLADEAMKIVKGTDQVVLVMGLDQTQEREAHDRVDLVLPGHQQKLVTRIASAANKPVILVLLCGGPVDITFAKNDQNIGSIIWAGYPGEAGGRALAEIIFGDHNPGGRLPITWYPQNLTKIPMTDMRMRPEPSSGYPGRTYRFYQGLKVFEFGYGLSYTNYSYEFLPLTKDKVYLNNQSSDKIALGYKSVSEMGTELCEKSKLPVTVRVQNNGEMDGKHAVLLFVRQAKTGNERPIKQLVGFNNVDLKAGEKAEIKLELSPCEHLSSAEGDGQMVVDEGSYFLSIGDKESEITVVFSEDTSDAATSKLMILPRILIFFYIYSFIHSFIPMHIVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQL0</accession>
    <name>A0A0D2TQL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF547 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G163400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQL0"/>
    <dbReference type="STRING" id="29730.A0A0D2TQL0"/>
    <dbReference type="Gramene" id="KJB77888">
        <property type="protein sequence ID" value="KJB77888"/>
        <property type="gene ID" value="B456_012G163400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778890"/>
    <dbReference type="eggNOG" id="ENOG502QRMJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PKEMRHE"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006869">
        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054:SF20">
        <property type="entry name" value="DUF547 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04784">
        <property type="entry name" value="DUF547"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ternary complex factor MIP1 leucine-zipper" evidence="2">
        <location>
            <begin position="40"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="1">
        <location>
            <begin position="289"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB77888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="58488" checksum="D78C8D0026D740CB" modified="2015-04-29" version="1">MQMEFMEEATTHKRSSSFPFHNTIKSHVDANKDQIFNPKVQHSLKQEILQLEEQLQDQFVVRRVLEKALSPRPFTYDVAVDEFHSSKFQAAKELIKDIAVLELEIAYLEKYLLSLYRKMFDRRFSCLNITEENPESTSVAHDIKECNNDVRGTETLLDSSIYRSHSSLSRQSAYAIASPQKTGVSYHIPETPNWLSEEMIKTVSNIYFELADPPLNNHDCFSSPISYPSSVNDTWSTPQCFHVDNNRGPYCKMVKVQGIYRDSNKLQDIEHKLQYYRSLVYQLEEIDVRTMKHEEKLAFWINVHNSLVMHAYLVYGIPKNSTKRFSLLLKAAYNVGGYTISIETIQGSILGCKLQRPGQWLWFLFALKTKFKVGDPRRNYAIESPEPLLHFALCLGSSSDPAVRIYTPKEVFQELEVAKEEYIQANFSVNKEEKIELPKIMDYFAKDSDVCSAGLLQMLHQFMPQPLKKNLQVQLSCNRKNGKCIEWIPHNFAFQYLFSKELSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TVZ5</accession>
    <name>A0A0D2TVZ5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G058600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TVZ5"/>
    <dbReference type="STRING" id="29730.A0A0D2TVZ5"/>
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        <property type="protein sequence ID" value="KJB79613"/>
        <property type="gene ID" value="B456_013G058600"/>
    </dbReference>
    <dbReference type="OMA" id="CKINFLA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48216">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48216:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252909" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="128" mass="13664" checksum="2A47069227FE6E07" modified="2015-04-29" version="1">MASFNCFALAFLMALSFASIDVGVAARHLLQQPQTPSLLKITFPPLPSFPKPSFPRPSIPSFPSIPSFPKPSIPSFPRPGVLPPLPSRLPSRPKATLPPLPSIPSVPQIPTAIPSIPFFSPPLSHSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXK6</accession>
    <name>A0A0D2TXK6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_013G083600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXK6"/>
    <dbReference type="Gramene" id="KJB80158">
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        <property type="gene ID" value="B456_013G083600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783614"/>
    <dbReference type="eggNOG" id="KOG0483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECFSNMF"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000200">
        <property type="entry name" value="Homeobox-leucine zipper protein ATHB-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF176">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN ATHB-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="13">
        <location>
            <begin position="79"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="81"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="184"/>
            <end position="214"/>
        </location>
    </feature>
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        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB80158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="289" mass="32950" checksum="15BEE5A6DDC372E3" modified="2015-04-29" version="1">MSCNGMAFFPANFMLQTPHEEDHHHHQPPTSINQMLPSCTPQDFHGVASFLGKRSISFSGIDHVCEEGNGEDDLSDDGSQAGEKKRRLNMEQVKTLEKNFELGNKLEPERKMQLARDLGLQPRQIAIWFQNRRARWKTKQLEKDYDLLKKQYEAIKADNDALQAQNQKLHAEILALKGKEPTESINLNKETEGSCSNRSENSSDVKLGMSRTPTVIDSHPTSCRTLFPTSIRPTTAVAQLFQTSSSRPDNHLQCQKMDQIVKEEGLGNMFCNIEDQTGFWPWLEQHHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TY46</accession>
    <name>A0A0D2TY46_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G310300</name>
        <name evidence="4" type="ORF">Gorai_013085</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJB60526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2TY46"/>
    <dbReference type="STRING" id="29730.A0A0D2TY46"/>
    <dbReference type="Gramene" id="KJB60526">
        <property type="protein sequence ID" value="KJB60526"/>
        <property type="gene ID" value="B456_009G310300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770884"/>
    <dbReference type="eggNOG" id="ENOG502QRJR">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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    <dbReference type="InterPro" id="IPR000157">
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    </dbReference>
    <dbReference type="InterPro" id="IPR058874">
        <property type="entry name" value="WHD_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32472:SF11">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN (TIR-NBS CLASS)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA REPAIR PROTEIN RADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25895">
        <property type="entry name" value="WHD_plant_disease"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="2">
        <location>
            <begin position="149"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB60526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0596256.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="986" mass="112633" checksum="7E3E3E7329643371" modified="2015-04-29" version="1">MDLGEGSGRLGSLPTTTSRTMSSSSSAFFSANQSPLFSPRSSTCQLSESARFDVQCDSTNLSADPSSSSSGIPDPECLANVGFAVSDESLMAAACVSSDFPKFDYSSCTYSHLHDNGFSGIIEKHRRHIRSHDMMFSPVPISLSSYQQSSYDVYIGLHGRKPSLLRFTNWLRAELEVQGMSCFVSDRARFRNSRKHGRIERAMDASSFGVLILTKKSFRNPYTIEELRFFSSKKNLVPIYFDLNMGDCLVRDIVEKRGELWEKHGGELWISYGGLEKEWKEAVNGLVRADAWKLEALEGCWRDCILRAVTYLAMRLGRRSVVDRLTKWREKVDKEEFPFPRNENFIGRKKELSELEFILFGDISGESERDYFELKARSKRKHLTIGWSKSRSLEERRRECNWENGSRKGKEPVIWKESEKEIEMQSTERQRYQRPRSSGRNSRRKRPAKFIYGKGIACVTGDSGIGKTELLLEFAYRYHQRYKMVLWIGGESRYIRQNYLNLWSFLDVDVRVENGIDKRRMKSFEEQEEAAISRVRKELMRNIPFLVVIDNLESEKDWWDQKFVMDLLPRFGGETHILISTRLPRVMNLEPLKLSYLSGVEAMSLMQGSVKDYPIAEIDVLRVIEEKVGRLTLGLAIVGAILSELPINPSRLLDTINRLPSRDFSWSGREAHSLRKNTFLLQLFEVCFSIFDHADGPRSLATRMVQVSGWFAPAAIPVSLLALAAHKIPEKHKGTRFWRKLLRSLTCGFSSCYSKRFESEASSMLLRFNLARSSTKEGYIHFNEVIRMYARRRGVTGVSHAMVQAVVSHASLSHHSEHIWAVCFLLFGFGNDPTVVELRVLELLYIVKEVILPLAIRTFMVFSRCSAALELLRLCTDALEAADQAFVTPVEKWLDKSLCWGPIRTNAQLNPCLWQELALTRATVLETRAKLMLRGGQFDIGDDLIRKAIFIRNSISGEDHPDTVSARETLSKLTRLLANVQAHTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1Q7</accession>
    <name>A0A0D2U1Q7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G150500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_013G150500"/>
    </dbReference>
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        <property type="gene ID" value="B456_013G150500"/>
    </dbReference>
    <dbReference type="OMA" id="SYKLTMG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132:SF135">
        <property type="entry name" value="OS02G0799700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132">
        <property type="entry name" value="OSJNBB0118P14.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB81573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="111" mass="11910" checksum="299CCCEDE44D8741" modified="2015-04-29" version="1">MGENTAEDVTKSRKTKQVYKGRLSYKLTMGEVNSVAMDRHPTTTLYGTPGEAAAKSSGSNSNCLCSPTTHAGSFRCRYHRAGFPRAASVGSKLSMLGDTKSHHISDSLQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8J7</accession>
    <name>A0A0D2U8J7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G083800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2U8J7"/>
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        <property type="protein sequence ID" value="KJB65189"/>
        <property type="gene ID" value="B456_010G083800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRDNIPR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="35"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB65189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="267" mass="29898" checksum="B0E8BF66C8C697E5" modified="2015-04-29" version="1">MAHTHSAQSPVIQQQRMIIPNKHGEKLVGLLHETESKEIVILCHGFKSTKDYNTLTNLAAALEKEGISVFRFDFAGNGESEGSFQYGNYYREADDLHAVLQHFSGENRVVSAILGHSKGGIVVLLYASKYQDIHIVVNVSGRYDLKRGIAERLGEDFMEIIKKDGHIDVKNKTGGVEYRVTEEALMDSLRTDMHEACLKIDKECRCQCQMNINSVEDALEFAKVIPNHQLHIIEGANHGYTSHQNELASTVVKFIKSALEQDKVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UML8</accession>
    <name>A0A0D2UML8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G013300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UML8"/>
    <dbReference type="Gramene" id="KJB69266">
        <property type="protein sequence ID" value="KJB69266"/>
        <property type="gene ID" value="B456_011G013300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R7U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB69266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="67" mass="7019" checksum="486B9AA67B75F041" modified="2015-04-29" version="1">MAFFSTSFVACFFSGSNKVASQGEDTQPSSSTVSKAGSDAKLKEGKAKNNPPIPITYFPIGSKLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQE3</accession>
    <name>A0A0D2UQE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G195100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Substrate-binding subunit of tRNA (adenine-N1-)-methyltransferase, which catalyzes the formation of N1-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQE3"/>
    <dbReference type="STRING" id="29730.A0A0D2UQE3"/>
    <dbReference type="Gramene" id="KJB58105">
        <property type="protein sequence ID" value="KJB58105"/>
        <property type="gene ID" value="B456_009G195100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770772"/>
    <dbReference type="eggNOG" id="KOG1416">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRCRPYQ"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038170">
        <property type="entry name" value="tRNA_m1A_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR038170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="489" mass="54137" checksum="C2D5B76004235CB7" modified="2015-04-29" version="1">MLLSELKLFQILVRKVQFFLTLCGIRANILFNKGSNMSENKPESGPTVNPRVTWEGCSVLLDINDGDRLLFARLSAGSTLKIGNKTFSLQPLIGCPFGSLFQVESGKEKPYLSRFIPPTEENNVQDEGGCQLQEESRDNRAIIDNNQAQSLTGDDIDAMRRQGATGNEIVEALIANSATFDKKTQFSQEKYRLKKQKKYAPRVLLRRPFSRSICEAYFKKYPARIGFLRVDALSLLLSMANVTANSDVLVLDMVGGLVTGAVAERLGGTGSVCNTYLGGTPYPMEIIRMFNFNNEICKRVLRCSVNDLCAVQNETSEQVSQHEDVCTMESQSDEKISLSVSTEEVHLSSKNGVSDLVPENELSTTGKTCKTPKAGEKAPKEAIQSWKENGFSSLIIAAPEQDAWSLVKDLLPLLTYSAPFAIYHQYLQPLATCMNNLQLEKMAIGLQLSEPWLREYQVLPSRTHPCMQMSGSGGYILSGTRAYSNTSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR22</accession>
    <name>A0A0D2UR22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HVA22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G102500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR22"/>
    <dbReference type="Gramene" id="KJB71049">
        <property type="protein sequence ID" value="KJB71049"/>
        <property type="gene ID" value="B456_011G102500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777570"/>
    <dbReference type="eggNOG" id="KOG1725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF150">
        <property type="entry name" value="HVA22-LIKE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB71049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="192" mass="21959" checksum="492B4B4D3AA8B27F" modified="2015-04-29" version="1">MAFLGSDLTSEVGLRLLLWPLGSNIVTRAACCSVGVVLPVYSTFRAIERKDENEQQKWLIYWAAYGSFTLVETFSDKLLSWFPYYYHFKFAFLVWLQLPSTEGAKQIYKNHLRPCLLKHQARVDQLMCIASTEMARFITAHQKEFRFVRAMIIKIIGSDPKVSGTELAEPRGLPAIDDETRTTANPESDNED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTF1</accession>
    <name>A0A0D2UTF1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G129500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTF1"/>
    <dbReference type="STRING" id="29730.A0A0D2UTF1"/>
    <dbReference type="Gramene" id="KJB71561">
        <property type="protein sequence ID" value="KJB71561"/>
        <property type="gene ID" value="B456_011G129500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774929"/>
    <dbReference type="eggNOG" id="ENOG502S1GQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMNTINA"/>
    <dbReference type="OrthoDB" id="691043at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33257">
        <property type="entry name" value="OS05G0165500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33257:SF58">
        <property type="entry name" value="REJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="181" mass="20078" checksum="4B3A2C02535C04B0" modified="2015-04-29" version="1">MFTTSPDHLPHNKSLEIKQDDKFFSRLLSKENSVANPSFRVSVANPSFRVYYGGLPGAVPFMWESQPGTPKYTFSDTSIPPLTPPPSYYSNSNSKPIKNKHSRSGLFQALFPKMISLKKTSSLVPTSPPPPPSSSPMFLAIRPKKYQKRSRFFTPDDEADTAAIGSPTSTLCSDIGRGKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UX58</accession>
    <name>A0A0D2UX58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G234200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UX58"/>
    <dbReference type="STRING" id="29730.A0A0D2UX58"/>
    <dbReference type="Gramene" id="KJB73469">
        <property type="protein sequence ID" value="KJB73469"/>
        <property type="gene ID" value="B456_011G234200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776768"/>
    <dbReference type="eggNOG" id="ENOG502QWS8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNNHCDE"/>
    <dbReference type="OrthoDB" id="645697at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000002">
        <property type="entry name" value="Nac domain-containing protein 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF210">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 86-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="8">
        <location>
            <begin position="32"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="252"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="313"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="400"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB73469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="449" mass="49852" checksum="CA4D92748DAB16EC" modified="2015-04-29" version="1">MGGETSLTLVPGPTSPPPSAAAAKTGGSATALAPGFRFHPTDEELVSYYLKRKISNKPVRFNAMAEVDIYKHEPWDLSDKAKLQTRDQEWYFFSLLDKKYGNGGRMNRATNQGYWKATGKDREVRHNTHLIGMKKTLVFHSGRAPDGMRTNWVMHEYRLVEEELEKIGALQGYVLCRVFHKNNIGPPNGNRYAPFIEAEWDDGSIPLVLGVDTGDDGVAGNDAIAGSDVATTENAAVENNADQMIGFEQETEHAGKDALPNDEVPRETLNDKTDDCPPLPPCKVERPDDCPPICMLNREASLPLLRYKRRRHTDLGPNHANASENSTRTTQDRCSSTTTTAAAATTTSPSSATTTAISALLEFSLMESLELKENNHRVPPPTFDIANLDSVVPPSCMKLINELQKEIRKISVERETLKLEMMSAQTMINILHSRIDFLSKENEELKRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2J0</accession>
    <name>A0A0D2V2J0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G060600</name>
        <name evidence="3" type="ORF">Gorai_004228</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Wang Z."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="5 13"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V604"/>
    <dbReference type="STRING" id="29730.A0A0D2V604"/>
    <dbReference type="Gramene" id="KJB77871">
        <property type="protein sequence ID" value="KJB77871"/>
        <property type="gene ID" value="B456_012G1621001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDIQHAC"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000074">
        <property type="entry name" value="Squalene monooxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF8">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Squalene epoxidase" evidence="14">
        <location>
            <begin position="131"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB77871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="450" mass="49780" checksum="4524F8D3846A7F71" modified="2015-04-29" version="1" fragment="single">DGRQVRVIERDLNPPDRIAGESLMPGGYLKLIELGLEDCVDEIDAQRNQGYILYKDGKNAPISYPLEKFHSHVVGKSFHNNRFVQKLRKKAASLHNVSLEQGTVTSLLEENGTIKGGHYKDKSSQMLTAYASLTVVCDGCFSNLRRSLCNPKVDVPSYFVGFILTNCKLSDQNHGAIILADPSPIVFYPISSTEIRCMVDVPSQNLPSLSNGEMSHYLKTLVAPKVFPETYDSFISAIEKKDNIKIMPNRIMADAPHRTPGALLIGDSLNMRHAITGGGMTVALSDVVLLRDLLRPLHDLSDASVVCKYLQSFYTLRKPMSSTINILASVLHKVFSSSSDPTIEDIQHACIGYLRLGGVFSSGLSAMISGLCPRPLSLAFHLFALAIYGVGRLLLPFPSPKRLWNGAKLFWVSSNIIFPILHSEGVRQMFFPLTVPAYYRTPPRSKDLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VC40</accession>
    <name>A0A0D2VC40_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cysteine synthase</fullName>
            <ecNumber evidence="9">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_013G113100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 9">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="9"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VC40"/>
    <dbReference type="STRING" id="29730.A0A0D2VC40"/>
    <dbReference type="Gramene" id="KJB80642">
        <property type="protein sequence ID" value="KJB80642"/>
        <property type="gene ID" value="B456_013G113100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80644">
        <property type="protein sequence ID" value="KJB80644"/>
        <property type="gene ID" value="B456_013G113100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80646">
        <property type="protein sequence ID" value="KJB80646"/>
        <property type="gene ID" value="B456_013G113100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783524"/>
    <dbReference type="eggNOG" id="KOG1252">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCIVADH"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031977">
        <property type="term" value="C:thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015979">
        <property type="term" value="P:photosynthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009643">
        <property type="term" value="P:photosynthetic acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010310">
        <property type="term" value="P:regulation of hydrogen peroxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090322">
        <property type="term" value="P:regulation of superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000006">
        <property type="entry name" value="Cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="5 7 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="92"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="264"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB80646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="394" mass="42840" checksum="A1535BE59797E3EC" modified="2015-04-29" version="1">MSLSSSLLHLPPPKPFLCIPKQYSFPPFNASLNFSFYDKPMLIVKSASFAATRRASSLIVEEEEEEEEEEDEEEQEQEQVEGFEAVNIAEDVTQLIGRTPMIYLNKVTDGCVANIAAKLESMEPCRSVKDRIGLSMVCEAEDSGAISPRKTILVEPTSGNTGLGIAFVAATKGYKLIVTMPASINLERRILLRAFGAEIVLTDPEKGLKGAVDKAEEIVLNTPNAFMLQQFDNMANTKIHFETTGPEIWEDTLGNVDIFVAGIGTGGTVTGTGQYLKMKNKEIKVVGVEPAERSIVSGENPGYVPSILDVKLLDEVVKVSNDEAVDMARKLALEEGLLVGISSGAAAAAAISLAKRPENAGKLIVVIFPSFGERYIPTVLFRSIHEEVQQMEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCN3</accession>
    <name>A0A0D2VCN3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_010G194900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VCN3"/>
    <dbReference type="STRING" id="29730.A0A0D2VCN3"/>
    <dbReference type="Gramene" id="KJB67520">
        <property type="protein sequence ID" value="KJB67520"/>
        <property type="gene ID" value="B456_010G194900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772891"/>
    <dbReference type="eggNOG" id="ENOG502QTQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THQKSID"/>
    <dbReference type="OrthoDB" id="1932925at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF349">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="8">
        <location>
            <begin position="75"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="7">
        <location>
            <begin position="129"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB67520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="422" mass="48899" checksum="9383D8725EF06AF7" modified="2015-04-29" version="1">MKPPLSSSSSAVLRKARLSPYLFTLLAFIVFVSILYGEDFMCTLGQLEPIPGRAMSKPVKRRGKLAFAIGKGEEGCDIFRGRWVRDELTRPLYEESECPYIQPQLTCQEHGRPDKDYQKWRWQPRGCDLPSFNATLMLETLRGKRMMFVGDSLNRGQYVSMICLLHKLIPNDQKSMKTHKNGSLTVFKARDYNTSIEFYWAPFLLESNADNAVVHRISDRVVRKGSINKHGKNWKGVDILVFNTYLWWMTGLEMKVLKGSFEEENKEIIKVSTEEAYGMGMRSMLRWVRKNMDRKKTRVFFTSMSPTHAKGIDWGGELGENCYNQTTMIEDPNYWGSDSRKSIMKVIGEVFSKSKYPITFLNITQLSNYRKDAHTSIYKKQWNPLTPEQLANPISYADCTHWCLPGLQDTWNELLFAKLFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJS3</accession>
    <name>A0A0D2VJS3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Syntaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G0776001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJS3"/>
    <dbReference type="STRING" id="29730.A0A0D2VJS3"/>
    <dbReference type="Gramene" id="KJB70530">
        <property type="protein sequence ID" value="KJB70530"/>
        <property type="gene ID" value="B456_011G0776001"/>
    </dbReference>
    <dbReference type="OMA" id="AFQINIA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000095">
        <property type="entry name" value="Syntaxin-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Syntaxin N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB70530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="8197" checksum="48CDE71E8DB3F9EB" modified="2015-04-29" version="1" fragment="single">MSFRDLEARRPLVSRQNLINGKQDATQAVASGIFQINTAVSTFQRLVNALGTPKDTPELREKLHKTRLHIGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VMG9</accession>
    <name>A0A0D2VMG9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G147100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_011G185200"/>
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        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB72565.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Romanel E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
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                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="match status" value="1"/>
    </dbReference>
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    </evidence>
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        <source>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Probable component of the PAM complex at least composed of a mitochondrial HSP70 protein, TIMM44 and TIMM14. The complex interacts with the TIMM23 component of the TIM17:23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXH1"/>
    <dbReference type="SMR" id="A0A0D2VXH1"/>
    <dbReference type="STRING" id="29730.A0A0D2VXH1"/>
    <dbReference type="Gramene" id="KJB76540">
        <property type="protein sequence ID" value="KJB76540"/>
        <property type="gene ID" value="B456_012G094000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780849"/>
    <dbReference type="eggNOG" id="KOG0723">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPRMNKR"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254580" description="J domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB76540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="112" mass="12120" checksum="C8F81C703B1887AA" modified="2015-04-29" version="1">MATPFFAGLAVAAAALAGRYGIQAWQAFKARPPKPRMRKFYDGGFQPTMTRREAALILGVRENATAEKVKEQHRKVMVANHPDAGGSHYLASKINEAKDVMLGKTKGSGSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W095</accession>
    <name>A0A0D2W095_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Potassium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G171200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Potassium transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W095"/>
    <dbReference type="Gramene" id="KJB77990">
        <property type="protein sequence ID" value="KJB77990"/>
        <property type="gene ID" value="B456_012G171200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHNFEDG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF98">
        <property type="entry name" value="POTASSIUM TRANSPORTER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="4">
        <location>
            <begin position="19"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU321113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB77990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="681" mass="76191" checksum="C5F937F21A802F64" modified="2015-04-29" version="1">MDLETGFHHKESWRTVLTLAYQSLGVVYGDLSTSLYVYKSTFDEDIHHSETNEEIYGVLSFVFWTLTLVPLLKYVFIVLKADGNGEGGTFALYSLLCRHARVNSLPNCQLADEELSEYKKDGGVNGLSPKSNLGSRLKSSLEKHRVLQRFLLVLALIGTCMVIGDGILTPAISVFSAVSGLELSVLKEHHKYVEVPVTCIILICLFALQHYGTHRVGYLFAPVILIWLLCISSIGLYNIMYWNPHVYRALSPFYMRLVVLGGILLCITGSEAMFADLGHFSQLSIKIAFTSLVYPSLILAYMGQAAYLSWHHNIKSDYQIGFYVSVPEKLRWPVLVIAILAAVVGSQAIITGTFSIIKQCSSLGCFPKVKIVHTSSKIHSQIYIPEINWLLMVLCLAVTVGFRDTRHMGNASGLAVITVMLVTSCLMSLVIVLCWQKSVFLAICFVFFFGTIEALYFTASLVKFLEGAWVPIALSFIFLIVMCVWHYGTLSPDLGMLVSGIPAIFSDFVTNFPAFHQVLVFLCIKECRLYRCIVRYGYCDFHKDDIEFEKDLVCSIAEFARSENGSPNDVKVDRETDNDDKMKVVGTCSTHLDGIQMSEDDSNDIEEASPLELKEIQSPPTIKPRKKSTDTCLRAKQGSILIKKLVIDFEYEFLQKNSRPSTLALTVPHVSTMEVGMVYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MT63</accession>
    <name>A0A0D2MT63_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G036800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB22240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MT63"/>
    <dbReference type="STRING" id="29730.A0A0D2MT63"/>
    <dbReference type="Gramene" id="KJB22240">
        <property type="protein sequence ID" value="KJB22240"/>
        <property type="gene ID" value="B456_004G036800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22242">
        <property type="protein sequence ID" value="KJB22242"/>
        <property type="gene ID" value="B456_004G036800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790286"/>
    <dbReference type="eggNOG" id="KOG3702">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKRTSHQ"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="RNA binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
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    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF32">
        <property type="entry name" value="RNA BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="521"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="111"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB22242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="693" mass="76341" checksum="07A3BBEBFCDEF3D2" modified="2015-04-29" version="1">MKMGSVDRVNDLTFKVNFSGDGAAKLKDRVKEKLKEFMGDYTDDTLVEYVIVLLRNGRRKGEAMNELNVFLGDDSESFVSWLWDHLASNLDLYAPSREPHLDEGTRTTVLGNQSIGAESHQLDTDSERGKSTKFPRNRHNRDWKGLVRDAAEPPPLRSSEVENIRFEEKSSRKVSRGRSTSPQPTQKKRSRPDERQPIKREAVPNIDAPRRLLQFAVRDAVGTSRAPISAKEPSSKRLRSVVSTSSGDLPARPRRIQSVARVPNPMATVIKAVAEAAEDVTKVKNAGSVFDRLGPGMDVLETGDLHPEFRESLTEDEEYGDLNQPLEKTHSAYYQREECAGRHVGNVTALESQTGLASESLSDNEWYGDVDVVGHGVMDESHTGHAGRSSGNKGDNSLMVQYNVAKDDEILQTRNKDQNQSTIATNTSRKIVNISVNVNTWKPPHYQEPREASELDSRKPLPESEAVANKANHRLMENGNPVNVGNGNVKGAAYNQELSQKAVQPSASYAAARPLEDADSRTIFVSNVHFAATKDSLSRHFNKFGDVLKVIIVTDAATGQPKGSAYVEFMRKEAADNALSLDGTSFMSRILKVVKKSSAPQEAAAPVMTWPRVARGSPFVAARFGRASFARGMPGAFRPHLPVKPGARSFQWKRDAQTTTTRTDAVTGTTVSSPTFRSLTYVRTEPKSAGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N1P4</accession>
    <name>A0A0D2N1P4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G213200</name>
        <name evidence="13" type="ORF">Gorai_015269</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N1P4"/>
    <dbReference type="STRING" id="29730.A0A0D2N1P4"/>
    <dbReference type="Gramene" id="KJB25877">
        <property type="protein sequence ID" value="KJB25877"/>
        <property type="gene ID" value="B456_004G213200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25878">
        <property type="protein sequence ID" value="KJB25878"/>
        <property type="gene ID" value="B456_004G213200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792229"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010229">
        <property type="term" value="P:inflorescence development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010103">
        <property type="term" value="P:stomatal complex morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010098">
        <property type="term" value="P:suspensor development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06632">
        <property type="entry name" value="STKc_MEKK1_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000186">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF17">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE YODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="405"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="284"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="718"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="50"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB25877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0584460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="897" mass="96454" checksum="F8B67E7DC837F415" modified="2015-04-29" version="1">MPPWWGKSSSKEDKKKASKESFIDAINRKLKITSDEKSTSRSGGSRRSRSGAVSQRGSLSRVPSRSPSPSTQVSRCQSFVERPHAQPLPLPGGNHANVLRSNSGINASIRPGFDRGSKPSPLPKPGQFSKKLDRVDGEGDFATASISSDSSIDSDDPSDSRLLSPLTSDYENGQRTAANSPSGTKHMDQLSDVNQESKEILKPSNISFNNQYLSTSPKRGSMTNHVQNLQIPQRGALSSAPDSSMSSPSRSPLRAFGLEQVWNSGPGTGKPFSDIVFLGSGQCSSPGSGHNSVGGDMSGQLLWPQSRCSPECSPLPSPRMTSPGPSSRIHSGAVTPLHPRAAGAAAESPTSRPDDGKQQSHRLPLPPITISNTCPFSPGYSAATSPSLPRSPGRAENPTSPCSRWKKGRLLGRGTFGHVYLGFNSESGEMCAMKEVTLFSDDAKSKESAQQLGQEIMLLSQLRHPNIVQYYGYETVDDKLYIYLEYVSGGSIYKLLQEYGPFGESAIRNYTQQILSGLAYLHAKNTVHRDIKGANILVDPNGRVKLADFGMAKHITGSSCPLSFKGSPYWMAPEVIKNSNGCNLAVDIWSLGCTVLEMATTKPPWSQYEGVAAMFKIGNSKELPAIPDTLSEEGKDFVRQCLQRNPLHRPTAAWLLEHPFIKNAAPLERPIFSADASDPSPAVANAMRTLGIGNARNFPCIDSEGTASLPCRALKTVSGSSDIHTPRNMSCPVSPIGSPLPHPRSPQNLSGRMSPSPISSPHALSGSSTPLTGGSGTIPFHHQKQPMAYLHEGLGIIPRSQTNFYGNANNPYQEPKPDMFRGISQASNVSQEMISSDTGAFGKQYGWPGHGDHRDFYNGQPALADHVSQQLLRDHVKLKPSLDLNPGSSMLGRNGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N5R3</accession>
    <name>A0A0D2N5R3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G165300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N5R3"/>
    <dbReference type="Gramene" id="KJB27482">
        <property type="protein sequence ID" value="KJB27482"/>
        <property type="gene ID" value="B456_005G165300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="entry name" value="MoeA, C-terminal, domain IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB27482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="80" mass="9132" checksum="0706C4C805278842" modified="2015-04-29" version="1">MMDRGMQDKFRVIVSLIIGLLTFSICCSVRSFLDLIYLFVAESTGHQMSSRLLSMKSANSLKLCLVIIRKETFLLNKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8W0</accession>
    <name>A0A0D2N8W0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G128900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8W0"/>
    <dbReference type="STRING" id="29730.A0A0D2N8W0"/>
    <dbReference type="Gramene" id="KJB09178">
        <property type="protein sequence ID" value="KJB09178"/>
        <property type="gene ID" value="B456_001G128900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1134">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WEFIHRV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF117">
        <property type="entry name" value="CSC1-LIKE PROTEIN RXW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB09178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="11711" checksum="6D1E7D92383F27ED" modified="2015-04-29" version="1">MQPSIHSIYVWEFIHRVVTGYLPSVILILFLYAVPPTMMLFSAMEGNISRSQRKRSACIKVLYFTIWNVFFVNVLSGSIIRQLTVFSIFKDAPKQLARAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NCD3</accession>
    <name>A0A0D2NCD3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G245300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NCD3"/>
    <dbReference type="STRING" id="29730.A0A0D2NCD3"/>
    <dbReference type="Gramene" id="KJB10623">
        <property type="protein sequence ID" value="KJB10623"/>
        <property type="gene ID" value="B456_001G245300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4NX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITSCLND"/>
    <dbReference type="OrthoDB" id="625231at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB10623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="95" mass="10699" checksum="B6720D1990197104" modified="2015-04-29" version="1">MGFRLPRIVNAKPSLKRTLSSSETIIIPKSHFPVYVGEVENKRFVVPISFLKHPSFQNLLSHAEKEFGFNHPMGALTIPCSEEAFIDLTCNLQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NHD1</accession>
    <name>A0A0D2NHD1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G025500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NHD1"/>
    <dbReference type="STRING" id="29730.A0A0D2NHD1"/>
    <dbReference type="Gramene" id="KJB12588">
        <property type="protein sequence ID" value="KJB12588"/>
        <property type="gene ID" value="B456_002G025500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774793"/>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGCSTFP"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19094">
        <property type="entry name" value="AKR_Tas-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000005">
        <property type="entry name" value="NADP(H)-dependent aldo-keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="79"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="420" mass="47544" checksum="098C66EE8E758B99" modified="2015-04-29" version="1">MAVSSSTVSASVPPFLCCNTTKIPSFKVPRHTPLRLCNAKRTQIWVKRSCFKSTITAKVAQQSDLQYRKLGDSDLQISEITLGTMTFGEQNTEKEGHEMLSYAFEHGINALDTAEHYPFPMKKETSGRTDLYIASWLKSQPRDKVILATKVCGYSERSAHLRDNAKVLRVDAVNIRESVEKSLKRLNTDYIDLLQIHWPDRYVPLFGEYFYDSSKWRPSIPFVEQLKALQEVIDEGKVRYIGVSNETSYGVMEFVHAARVEGLSKIVSIQNSYSLLVRRFEVDLVEVCHPKNCNIGLLSYSPLAGGALSGKYLDINSEAAKKGRFNLFPGYMERYNKSIAKEATVQYIEMAKKHGLSPVQLALGFVRDRPFMTSLIIGATSVEQLKEDIDAFLTTQRPLPPEVMEDIEAIFKRYKDPANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1W1</accession>
    <name>A0A0D2P1W1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G151300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2P1W1"/>
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        <property type="gene ID" value="B456_003G151300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789050"/>
    <dbReference type="eggNOG" id="ENOG502QS78">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDMDVGE"/>
    <dbReference type="OrthoDB" id="995650at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31934">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31934:SF2">
        <property type="entry name" value="RNA-DIRECTED DNA METHYLATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB20488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="357" mass="41250" checksum="0111724C74BBDD98" modified="2015-04-29" version="1">MASNGESSSTPPQSTTDKPVIVRVKRKVSQFRLDAFWLEINERPLKRPFSDFEKLSISESSQREELKSKKVFVRHVDTLTSSQATVDIVQSFIPNSADVTDGNTKSQEGRRPQKTNYRQEQLSKSIQKQEEMAKNARFEQIWRSRRGKKEAVDEMYHFYDVLRVEVEEKSNSMQIEEESLEDRELLSSYLPLLREFIPAAAAEIESDIRAYMFEKDADGYVYDYYTVKNDMDVGEEDMASNPFPLVKVDDEDFYDVPYESEYDSEDSNAEDNPRNDYPDESSEEEEEEEDEDEETKASDQSGEGSSKSSEVGSVSGYDEEVLYEVDPYDDINGDSNHLGHGNSDYDTDGEDWRWSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P831</accession>
    <name>A0A0D2P831_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G128500</name>
        <name evidence="11" type="ORF">Gorai_018608</name>
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    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0589882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P831"/>
    <dbReference type="STRING" id="29730.A0A0D2P831"/>
    <dbReference type="Gramene" id="KJB41927">
        <property type="protein sequence ID" value="KJB41927"/>
        <property type="gene ID" value="B456_007G128500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPEYWEK"/>
    <dbReference type="OrthoDB" id="951142at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033326">
        <property type="entry name" value="BAH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="9">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB41927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0589882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="208" mass="23959" checksum="75D2CCAACAF35612" modified="2015-04-29" version="1">MSDVVNCFNDCAQKLLELHLASGFRKYFIWFKAKLQGSHIALIQAGKDLVNYAMINAIAIRKILKKYDKVHYSKQGQAFRSQAQSMHIEILQSPWLCELMAFRVNLRETKAISGKAPALFEGCYLTFNDGKPFLSCELFDSVKLDTDLTCSISLAGVYEGAVHLDELSILLRRSYREYWEQRLEKERVERVRQAKQHWESQCQASIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PFE0</accession>
    <name>A0A0D2PFE0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G2708002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PFE0"/>
    <dbReference type="STRING" id="29730.A0A0D2PFE0"/>
    <dbReference type="Gramene" id="KJB44752">
        <property type="protein sequence ID" value="KJB44752"/>
        <property type="gene ID" value="B456_007G2708002"/>
    </dbReference>
    <dbReference type="OMA" id="HEQCFAL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248501" description="Cupin type-1 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="3">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB44752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="106" mass="11309" checksum="18912588C42EADCE" modified="2015-04-29" version="1" fragment="single">MKRLQLFVAAFAILASSSLLASASDPSPLQDFCVAINDTKNGVFVNGKFCKDPKLANAEDFFYSGLNIPRNTSNPVGSTVTPVNVAQIPGLNTLGISLVRIDYAPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PMJ4</accession>
    <name>A0A0D2PMJ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G042100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PMJ4"/>
    <dbReference type="STRING" id="29730.A0A0D2PMJ4"/>
    <dbReference type="Gramene" id="KJB28328">
        <property type="protein sequence ID" value="KJB28328"/>
        <property type="gene ID" value="B456_005G042100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796639"/>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052595">
        <property type="term" value="F:aliphatic amine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904585">
        <property type="term" value="P:response to putrescine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009751">
        <property type="term" value="P:response to salicylic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000004">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000012">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF71">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002260817" description="Amine oxidase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="30"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="13">
        <location>
            <begin position="127"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="249"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB28328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="683" mass="77643" checksum="8B81228E6AD7431D" modified="2015-04-29" version="1">MAHSSKIFCCFSFLFSTLSIIPLSHQLEQHPLDSLTPNEFIRVQAIVNQSHPTTTNDITFQYIGLNEPDKQALISWLQNHRTTPITAPPPRQAFVIARINHQTHELVVDLLYDNIVSDHIHHGFGYPLLTFEEQNGASQLVFNHAPFLAALNKRGLKVAEVICETFAIGWFGETKQNGRVVKVMCYYLDGTVNLYMRPIEAITVTVDLEAMKITHFRDRLVVPVPKAAGTDYRESEQKEPFGPELKGITVVQPDGPSFIIDGSRVRWANWDFHLSFDARVGPIVSLASIYDTEKQEFRRVMYRGFVSELFVPYMDLTEEWYYRTFFDAGEYGYGLCAVPLEPLRDCPANAVYMGAYVAAQNGMPIEMPNVFCIFERNAGDVMWRHTETMIPPDLITEVRPDMSLVVRMVSTVGNYDYINDWEFKQIGSIKVTVGLTGLLEVRGSKYTHKDQIDEEVYGTLLAENTLGAYHDHFITYHLDLDVDGESNSFVKSKLQTVKVTDQTSPRKSYWKVVSETAKTESDAKIKLGSDSAELLVVNPNKRTKMGNFVGYRLIPGSVASPLMTDDDYPQIRAAFTEYNVWVTPYNKSEKWAGGIYIDQSRGDDTLATWTSRNRRIENKDIVLWYTLGFHHVPYQEDFPLMPTISTGFELRPANFFEYNPVLKVKGPSNVRWPNCSVSSSGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRA9</accession>
    <name>A0A0D2PRA9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G115100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRA9"/>
    <dbReference type="Gramene" id="KJB29703">
        <property type="protein sequence ID" value="KJB29703"/>
        <property type="gene ID" value="B456_005G115100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="118" mass="14076" checksum="E6ECA77F5E4A798E" modified="2015-04-29" version="1">MERFFFLVDYEPPETSNVDGTRTDFIYISNCISTHKAWKILKTTYEGITRVKRSKFQMLITIFENLRMFETLAKFYAIQLLRSRPKRFLIEVIAIEETKDKHIVRVEKLIGSLQTKFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PXK2</accession>
    <name>A0A0D2PXK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">isochorismate synthase</fullName>
            <ecNumber evidence="5">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_008G190900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Isochorismate synthase involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Siderophore biosynthesis; salicylate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="5"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PXK2"/>
    <dbReference type="STRING" id="29730.A0A0D2PXK2"/>
    <dbReference type="Gramene" id="KJB50872">
        <property type="protein sequence ID" value="KJB50872"/>
        <property type="gene ID" value="B456_008G190900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIETRTM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000005">
        <property type="entry name" value="isochorismate synthase, chloroplastic-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044250">
        <property type="entry name" value="MenF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47253">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47253:SF4">
        <property type="entry name" value="ISOCHORISMATE SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="14">
        <location>
            <begin position="293"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB50872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="523" mass="58159" checksum="C66F7702A3627CE2" modified="2015-04-29" version="1">MAGAVVRHYLTTCFMDSETTKCKISYALHSHTRSLPLFHNKYETRRVVALMNGCEGDPKLPIGSIETRTLTAVPSPSKAMERLDVAIRDLKCNTPPLTSGILRLQVPIEEQIEAIEWLHAQHDNLPRCFFSGRRSRANGNGSNLLMDIGNGNGDTSFTHNLVGAAGVGSAVFFQQLHPFSYHDWRSIKRFLSAKCPLIRAYGAIRFDATANISPEWKAFGSFYFMVPQVEFDELEGSSMLAITIAWDNALSWTWDEAIHSLETTMQQIASVVVKLKKEASGEPILSKTHVPNKTHWDLAVKKALQEINTSSSQLVKVVLARSSRILTATNIDPIASLACLQVEGEDAYQFCLQPPNGPAFVGNTPERLFHRKWLSISSEALAATRARGESSDLDLQLEHDLLSSPKDHLEFTVVRENIQNKLESVCDRVVVEPKKTVRKLPRIQHLYAQLTGNLRREDDEFEILSSLHPTPAVCGLPKEAARLFISETEMFDRGMYAGPVGWFGGGESEFAVGIRSALVEKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q2W9</accession>
    <name>A0A0D2Q2W9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G226900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q2W9"/>
    <dbReference type="Gramene" id="KJB10821">
        <property type="protein sequence ID" value="KJB10821"/>
        <property type="gene ID" value="B456_001G226900"/>
    </dbReference>
    <dbReference type="OMA" id="WFDFITR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB10821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="70" mass="8230" checksum="DF2A7410A4C178F9" modified="2015-04-29" version="1">MRLLLATLNRIFDSLQTTYEGFQTSTVKAIYIFDLSAQEHVGAKFAVQIRSHTQKFFSKAHWFEFITRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q3E5</accession>
    <name>A0A0D2Q3E5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G282700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q3E5"/>
    <dbReference type="STRING" id="29730.A0A0D2Q3E5"/>
    <dbReference type="Gramene" id="KJB52897">
        <property type="protein sequence ID" value="KJB52897"/>
        <property type="gene ID" value="B456_008G282700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765594"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWIPPEC"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000093">
        <property type="entry name" value="Alpha-L-fucosidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000052">
        <property type="entry name" value="Putative alpha-L-fucosidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002261277" description="alpha-L-fucosidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="12">
        <location>
            <begin position="74"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB52897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="486" mass="55094" checksum="E79B16D99DED33B6" modified="2015-04-29" version="1">MAKFWYLVCMITFLELSKLAISRPEQVPTPPLPVLPLPTFSQLKWQQRELIMFLHFGVNTFTDSELGTGKENPSIFNPVGLDTKQWVTVAAEAGISLMILTAKHHDGFCLWPSKYTDHSVISSPWRNGHGDVVQEFIDAVKTHGGGGIDAGLYLSPWDRHDKRYGHDLQYNEYYLAQLQELLSKYGSVKEIWFDGFKGKEARNMSYYFSDWFAMVRELQSSINIFSDAGPDVRWVGNEKGSAGNTSWSTINSTLLSIGNLSVLDYLNTGDPKGTNWLPAECDVSIREGWFWHKSQSPKMLSQLLDIYYKSVGRNCVMLLNVPPNSTGLISESDIHRLKEFRTAIDTIFSTNLAEKCTVKVSSQRGGKGGGFGPENVLDNDHVWTYWSPKENKNEHWIEIKVPNAEEGMKFNVVRIQEPIGLGQRIIKHEIYVDGKKVVQGTTVGYKRLHRLEKVLHCRVVRIIVKESKGLPLISSTGLHLDPYWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q7I8</accession>
    <name>A0A0D2Q7I8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G021400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q7I8"/>
    <dbReference type="Gramene" id="KJB54117">
        <property type="protein sequence ID" value="KJB54117"/>
        <property type="gene ID" value="B456_009G021400"/>
    </dbReference>
    <dbReference type="OMA" id="SWCKKHV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37077:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB54117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="66" mass="7003" checksum="789163EB16A91C81" modified="2015-04-29" version="1">MSALSKVVASWCKKHVDGDDDDNDFDYAPAACMEGDGDDDDGDYDYAPAASLEGDDDGNYDYAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGR4</accession>
    <name>A0A0D2QGR4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_003G069600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGR4"/>
    <dbReference type="STRING" id="29730.A0A0D2QGR4"/>
    <dbReference type="Gramene" id="KJB18799">
        <property type="protein sequence ID" value="KJB18799"/>
        <property type="gene ID" value="B456_003G069600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18800">
        <property type="protein sequence ID" value="KJB18800"/>
        <property type="gene ID" value="B456_003G069600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788105"/>
    <dbReference type="eggNOG" id="KOG0584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KPTCESQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000046">
        <property type="entry name" value="probable serine/threonine-protein kinase WNK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="598"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB18799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="643" mass="72186" checksum="D4FC48BEF84E5C3E" modified="2015-04-29" version="1">MVVAETGEDVAVHAEPPDPDVLEIDPTSRYIMYNEVLGKGAFKTVYKAFDELNGIEVAWNQVRIEEVLQKPEDLERLYSEVRLLKSLKHSNIVRFYNSWIDDKKKTVNIITELFTSGSLRQYRKKHKKVDIKAVKSWARQILTGLVYLHSHDPPIIHRDLKCDNIFINGNQGEVKIGDLGLATVLEQSNAKSVIGTPEFMAPELYDENYNELVDIYSFGMCMLEMVTFEYPYSECRNSAQIYKKVSSGIKPAALSKVNDQEMKLFIEKCLVPAPQRLSAKELLMDPFLQANGSAKSRPFALPDIVMPKIGAFGDRCLMSEAPASTRNRPSSLDLGSDSELPVIKFLDNSLGIEVRRTNKGHVFLLKGEGNDENSVSLILRIADQNDRVRNIHFLFFLDSDTALSVSSEMVEQLELADQNDVFIAELIDLLLLNLIPGWKPCVSIDHLVPPNRRQTSRDYQYSQGHGETSLGSSQHTAHTDNGSQSKLCSNASTLGASDESTKQGPCSVKFNGKTSHAKFVVEDSGSEMSFASANSNEWNDKLSSVHSFMSAELGPMCCNGHGFKRSSSKLLSEAELYFHAESMSTNPESSSTSGPVEDEELRLELEMIELQYQEAMKEISKRRHEAIMDTRRRLSQKKMHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QK62</accession>
    <name>A0A0D2QK62_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G132900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QK62"/>
    <dbReference type="STRING" id="29730.A0A0D2QK62"/>
    <dbReference type="Gramene" id="KJB20099">
        <property type="protein sequence ID" value="KJB20099"/>
        <property type="gene ID" value="B456_003G132900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1060">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="66"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB20099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="169" mass="18858" checksum="759B60F55917E3EB" modified="2015-04-29" version="1">MFPQFGATAETLSKASTMVFWIGIDAHPYDNSDDIVNSIRRSVRLLSDFSLSSLKASTSPITSLRRPNEALLSINCFQKDLGDPNPLVRAWALRTMAGIRLHVIEPLVLVAVGKCARDPSVYVRKCAASALPNVHDLRLEEHTSAIEEVHLINLFLHGYFCFHVIHHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMG2</accession>
    <name>A0A0D2QMG2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G175000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QMG2"/>
    <dbReference type="Gramene" id="KJB20969">
        <property type="protein sequence ID" value="KJB20969"/>
        <property type="gene ID" value="B456_003G175000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007942">
        <property type="entry name" value="PLipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35358">
        <property type="entry name" value="OS06G0711100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35358:SF10">
        <property type="entry name" value="PLANT PHOSPHOLIPASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05278">
        <property type="entry name" value="PEARLI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB20969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="453" mass="51767" checksum="8E67434CAD0E2B2E" modified="2015-04-29" version="1">MEGNGNEQPKCQRSFNHRGRKNDCWDEVVKMLCMILGDDSISNIRWWDDKKVKIQEAFMQLEDMKSKNELQESCWTEVVKLLRIILGDESISTATSWELKVMKVVEAIAQLEDPQFGLKMLKKMMKESINQNTKVKEAFRLIESVLNQSEILVPNQDYTDEINGLDQTAYMSKEEIQSLQEDLAQLYILHIQANAISDQKAQSMTEAKAFGKVSGLLSKVSESCCAKMHDILDPINSIQGHFVQVEDEQCTLHFHGSKMIDEETLAEEVNFTLTYVGGRLETLTLKMQSDQKMIPPAHLNPESSNPMGALGDSLDIEEFLTDSPLESWLDNLISTAVIKGYEVYQRNADALNKIFQNHAHFADQFQLKDRVFQSNIMNALAEIYLKLESNLGKLELTEIDDILVKVKDMEVTGLELSWLLETLENQAKIKRLEEAIQESILELAKLKKKQRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQ58</accession>
    <name>A0A0D2QQ58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G103000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQ58"/>
    <dbReference type="STRING" id="29730.A0A0D2QQ58"/>
    <dbReference type="Gramene" id="KJB41413">
        <property type="protein sequence ID" value="KJB41413"/>
        <property type="gene ID" value="B456_007G103000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41414">
        <property type="protein sequence ID" value="KJB41414"/>
        <property type="gene ID" value="B456_007G103000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0067">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SLLDCCK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045015">
        <property type="entry name" value="AN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43254:SF3">
        <property type="entry name" value="C-TERMINAL BINDING PROTEIN AN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43254">
        <property type="entry name" value="C-TERMINAL BINDING PROTEIN AN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="132"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB41413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="647" mass="71100" checksum="52F4608A2CAF93FE" modified="2015-04-29" version="1">MNLASNSTTSPMLRSSSGMRHRDNPTPLPLVISLNCIEDCALEQEFLAGVAVVHHVPLSSLGEGKIEGAAAVLLHSLSYLPRAAQRRLRPYQLILCLGSSDRAVDSALAADLGLRLVHVDASRAEEIADTVMALFLGLLRRTHLLSRHALSASGWLGSVQPLCRGMRRCRGLVLGIVGRSASARSLASRSLAFKMSVLYYDIVEENGKVSRSSITFPPAARRMDTLNDLLAASDLISLHCALTDETIQIINAECLQHIKPGAFLVNTGSSQLLDDCALKQLLIDGTLAGCALDGAEGPQWMEAWVKEMPNVLILPRSADYSEEVWMEIREKAISMLQTFFCDGVIPKDATSDEDEEESEIVDEKEQFSIQEKESALRGSSGEQFTDDIQLSPESSLKKDTNQAKDYPNQNQHSGMSSGTPTKSDAKRSRSGKKAKKRHARRNNLQKSDEPLILEKESTSQREDDTAMSGTDQALSSGSRSPLDSRSRKTPKELTQGSTSDQLLKMSRNLSGQSGDLLKEGYVIAMYARDRPALHLSRQRVKGGGWFLDSMSNVTKRDPAAQFLVVCRSKDTIGLRSFAAGGKLLQINRRMEFVFASHSFDIWESWTLQGPLEECRLVNCRNPSAILDVRIEILAAVGEDDGVTRWLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSJ2</accession>
    <name>A0A0D2QSJ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Pectate lyase</fullName>
            <ecNumber evidence="4 10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G334700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSJ2"/>
    <dbReference type="STRING" id="29730.A0A0D2QSJ2"/>
    <dbReference type="Gramene" id="KJB60997">
        <property type="protein sequence ID" value="KJB60997"/>
        <property type="gene ID" value="B456_009G334700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765931"/>
    <dbReference type="eggNOG" id="ENOG502QQE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HECHARN"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF208">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113278" description="Pectate lyase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="160"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB60997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="434" mass="48010" checksum="4015836EC12B3F61" modified="2015-04-29" version="1">MGISSYSFFLFLFVVIIPTQESHIAEYDEYWTARELEAIENLDKAYHSNPEEVVRHYNDHFSRTMLEFYITKRVLAESKQGPCEVTNHVDSCWRCDPDWEKNRKKLANCAPGFARGTTGGKDGEFYVVTDPIDNAADPKPGTLRHAVTQAGPLWITFKGSMTIKLQQELIVTSDKTIDARGANVEICNGAGITIQFAKNIIIHGLQIHHIIPANGGKIKDGENHHGLRGDSDGDGVSIFGATNVWLDHLALHHCADGLIDVVQGSTAVTVSNCHFTDHNDVMLFGASDSYSADKKMQVTVALNHFGKGLVERMPRCRFGFIHVVNNDYNHWFLYAIGGTSNPTIISQGNRYSAPGFGAKEVTCRGLLKPGQWKNWNWVSQGDHFENGAFFTPSGNPSASKQFGADKMMPFKPGQMVPELTKYAGPLSCAISRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXQ2</accession>
    <name>A0A0D2QXQ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PROP1-like PPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G021000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXQ2"/>
    <dbReference type="Gramene" id="KJB21916">
        <property type="protein sequence ID" value="KJB21916"/>
        <property type="gene ID" value="B456_004G021000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRSVITW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000242">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000348">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033443">
        <property type="entry name" value="PROP1-like_PPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF432">
        <property type="entry name" value="(WILD MALAYSIAN BANANA) HYPOTHETICAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17177">
        <property type="entry name" value="PPR_long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PROP1-like PPR" evidence="4">
        <location>
            <begin position="138"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="172"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="208"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB21916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="494" mass="54841" checksum="96BE28A190992572" modified="2015-04-29" version="1">MRERLLYLLKHCSNLKDVETAHGSMVRTALHHDKLLLSQFIETCSSLGFSAYAHSVFSVNSQSHPHIYVFNTMIKGMTLCNSAFEALLVYKSIGRVGLRPDCYSFPFALKAVVDLRAMSLGTQIHSQAICAGLESNVHVVSALIQMYSSCARISDARKVFDEMPLASVCSDDVVVWMAMIAGYVKVGDPDTAMDLLSRMPRTQTDGAVLITWTSVIAGYAQMDRPDEAIAVFRKMQLENVVPDEIAMLAVLSACAQLGAFHIRLGECIHGYVKKRGFDQMVTLKNALIEMYSNSGNISNALHVFVNMTRRTVISWTTIISALAFHGLGTQALDMFSRMEMAQVKPNDITFIAVLSACAHVGLVNLGRYYFHAMKYRYGIQHEIQHYGCMIDLLGRAGYLAEALKLVSEMPFQPNAAIWGSLLAASNIHGDAELGELALLHLVQLEPWNSGNYALLSNIYASAGRWDKSVMARKMMRDKGVRKMPGWSFIQRKTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYU9</accession>
    <name>A0A0D2QYU9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G040500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYU9"/>
    <dbReference type="STRING" id="29730.A0A0D2QYU9"/>
    <dbReference type="Gramene" id="KJB22311">
        <property type="protein sequence ID" value="KJB22311"/>
        <property type="gene ID" value="B456_004G040500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790332"/>
    <dbReference type="eggNOG" id="ENOG502QQ2P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVFMENV"/>
    <dbReference type="OrthoDB" id="1915848at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006943">
        <property type="entry name" value="DUF641_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056813">
        <property type="entry name" value="GIL1_IRKI_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04859">
        <property type="entry name" value="DUF641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24994">
        <property type="entry name" value="GIL1_IRKI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF641" evidence="2">
        <location>
            <begin position="95"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="GIL1/IRKI C-terminal" evidence="3">
        <location>
            <begin position="418"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="175"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB22311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="477" mass="53602" checksum="20E858C54644C802" modified="2015-04-29" version="1">MNGYEAPITPIKPPQISEMFQKFALAFKTKTFEFFADEDNHNNGSHLSDSDGFSLLDSAEDFITDQKVVVIKPDPPPNSSSSSMNNVSHRGTIDTQIAECLVSSVFAAVSSFEASYLQLQTSQVPFVEESVKAADRALVSHLQRLSDLKRFYMELRRNPSSQVASSLGSCLEAQVQENQSKLRGLETVSNRLQEEIDEKDNEVSVLRKKLAEIHWGNTKLSKKLSGNLNSACDVLLTVRVFHSVLHDACRATHKFSKILIGLMIKAGWDLDLVANSIYPDIDYAKKGHTRFAFLSYVCLGMFRGFDSEGFSLIENEALCNGNKGTCSLKQLLEHISSNPMELLSKNQSCEFSRFCEKKYQDLIHPTMESSIFSNLDRNEAVLNSWRSLSVFYESFVCMASSIWTLHKLAFSFEPVVEIYQVERGLDFSMVYMEDVTKRYNFPGKTKVKVGFTVVPGFKIGRTVIQSQVYLGGSKCED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZY4</accession>
    <name>A0A0D2QZY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G032600</name>
        <name evidence="12" type="ORF">Gorai_022202</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0579962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZY4"/>
    <dbReference type="STRING" id="29730.A0A0D2QZY4"/>
    <dbReference type="Gramene" id="KJB12715">
        <property type="protein sequence ID" value="KJB12715"/>
        <property type="gene ID" value="B456_002G032600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775547"/>
    <dbReference type="eggNOG" id="KOG0610">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIHHRKW"/>
    <dbReference type="OrthoDB" id="432483at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05574">
        <property type="entry name" value="STKc_phototropin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000294">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000312">
        <property type="entry name" value="Serine/threonine-protein kinase OXI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45637">
        <property type="entry name" value="FLIPPASE KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="80"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0579962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="435" mass="48404" checksum="02E5E4E6315D33C8" modified="2015-04-29" version="1">MVDEEPYFPDTDTDLSFTSAITDTTLSSSSRSSSASSTLSLSFKEPHLSSPTIHHRKWDPRFSPIKLVTTDDGNLQLHHLKLIRHLGTGNLARVFLCQLKDHDGAFFALKVIDTEALTAEKLSHVQTEGQILSMVNHPFLPRLYAHIQASHYTCFLIDFCPNGDLFSLLRKQPGNRFSLPAVRFFAAEVLVALEYLHALGIVYRDLKPENVLLGEDGHIMLTDFDLCFVADVVPAFKFVRRRSGKPNRNRLSGGCFGPAAGLNDKGEVVPVAEPVTAFSRSCVGTHEYLAPEVVSGDGHGNGVDWWAFGVFVYELLYGTTPFKGASNEITLRNIASSSRQMRFAHAPGVEEAGISEAKDLIEKLLVKDPSRRLGCTSGAQDIKRHPFFDGINLPLIRQYKPPEVVGGAARERGQVDRVKRRRWLRKGLNCMMMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0U0</accession>
    <name>A0A0D2R0U0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_004G077800</name>
        <name evidence="17" type="ORF">Gorai_014313</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
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    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3C4</accession>
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        <name evidence="3" type="ORF">B456_002G109300</name>
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    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
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        <location>
            <begin position="75"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB13850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="232" mass="27153" checksum="900974C443A5693D" modified="2015-04-29" version="1">MAIKNEIVNSIDLGDNEIGNISTWSIPKMIYLAKSIFRSNDFAMLEIESLEQVKDSFSYKFEEEGLEKMGFTNNLRKCKKELEDRRDEVLKLREKVRGRGKFAEENYKRLLEEVESMYEKEHEIIDLISKNCKLENEKAKTESNLEILRKRFEELDKRVSCLETDFNTLQDEDDSKNNGIVEEIGVSENGRLKYVEANGHAPNANKNSTFLNFFCFVFVLIYYILYAFQNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_010G069800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SDCG">
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    </dbReference>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="entry name" value="OSJNBB0118P14.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132:SF147">
        <property type="entry name" value="WRC DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB64882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9091" checksum="63D0CA52B8348643" modified="2015-04-29" version="1">MCHANIPCGGKPDLLVQRSWFLLQASMVANDHHSPRVARDTGGSTGSMKWCMCSPTKHPGSFRCRHHHADYVWGGRFITKK</sequence>
</entry>
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            <fullName evidence="1">Glutaredoxin domain-containing protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G233700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792436"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="88"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB26131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="237" mass="26607" checksum="407B190588DBAE2B" modified="2015-04-29" version="1">MWRPWGNKKMPLRIHDTSSPFSCSSFKDIQHLCTQDSSASSKRNANVFYRVRIANSLLRSWGPARTGKITDSVSDPSISIPGAEKRVVVYFTSLQVVRSTFEDCKTVRSILHGFRVSIDERDLSMDSRFLNELRGILGQSNLTLPRVFIGGRYMGGAEEIKQLHEIGELKKIVERLPAAEPGTCVVCGGYRFLLCNECNGSRKLYTQKSGFKTCTACNENGLIRCPSCSCNFFFFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RA01</accession>
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        <recommendedName>
            <fullName evidence="1">Myb/SANT-like domain-containing protein</fullName>
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    <organism evidence="2 3">
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RA01"/>
    <dbReference type="Gramene" id="KJB26451">
        <property type="protein sequence ID" value="KJB26451"/>
        <property type="gene ID" value="B456_004G2423001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26452">
        <property type="protein sequence ID" value="KJB26452"/>
        <property type="gene ID" value="B456_004G2423001"/>
    </dbReference>
    <dbReference type="OMA" id="IVMAFNE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF8">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB26451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="161" mass="18744" checksum="E5146E68AE94139E" modified="2015-04-29" version="1" fragment="single">MGSNAPSSSDRARTNWTPTMERFFIDLMLDQMHRGNRLGHTFNKQAWTDMLSIFNAKFGCKYDRDTLKSHSTNLWKQYNDVKNLLEQNGFSWDDTRKLVVAPPHVWNAYIKGQPDAQVYRNRTLTNFSDLCLIYAYTQADGRYSRSSHDIDFDDDALGVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAQ1</accession>
    <name>A0A0D2RAQ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MsrB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G222100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2RAQ1"/>
    <dbReference type="Gramene" id="KJB16300">
        <property type="protein sequence ID" value="KJB16300"/>
        <property type="gene ID" value="B456_002G222100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786160"/>
    <dbReference type="eggNOG" id="ENOG502RZYC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHIGNAY"/>
    <dbReference type="OrthoDB" id="1907500at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045282">
        <property type="entry name" value="At4g08330-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33674">
        <property type="entry name" value="METHIONINE-S-OXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33674:SF8">
        <property type="entry name" value="OS01G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24046">
        <property type="entry name" value="At4g08330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB16300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18400" checksum="7B5CB5F69595A11B" modified="2015-04-29" version="1">MENSVFMNHIQHLNGNLLYSFSPASLGHVTYSCGSCGYELNLSSSSRNTTTIGSKYGKSIKRGIISFFSIDESRFTQVDEFQCVPYFSRHSWGLFRHRTKLLCRKCGNHIGNAYDEKTSGYPLVLDKSNSSPCNEVSSHRKYDVRIRALQPSSAQELGTPHFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RCP0</accession>
    <name>A0A0D2RCP0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K+ potassium transporter integral membrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G117100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAK/KUP transporter (TC 2.A.72.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RCP0"/>
    <dbReference type="Gramene" id="KJB27436">
        <property type="protein sequence ID" value="KJB27436"/>
        <property type="gene ID" value="B456_005G117100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPSA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHMLHTN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF4">
        <property type="entry name" value="POTASSIUM TRANSPORTER 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="4">
        <location>
            <begin position="132"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB27436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="37540" checksum="741B0FA858717899" modified="2015-04-29" version="1">MYFHLILFHFSKEPDASHLVNGSWVLIAGVSQARLFTLSLLDLLLGSKPQCMDSVKTALFKRHSNYNISVDEIGMKLDFVWALYVLNLTHLLTDFKTKKKYLNVMVMGVGLWHMLHVSNLSDCKFVLQTLKSSLVSLFPFSTDIANAYGIAEVVVMLVTTALVTLVMLLIWQTNLLMALCFPLLFESIELIYFSTVLSKVMEGGWLPLVFATFFLTVMYIWHYGSVLKYQSEVREKISMDFMIKLGSKLGTVRVPGTFQKISMDFMIELSSKLGTVVKVGLDMVDGEKKAALEAKWMKLQVAQLEAYARRTEFVAEQAKLLLKYYKSEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RE27</accession>
    <name>A0A0D2RE27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nodulin-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G143900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KJB30069.1"/>
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    <dbReference type="eggNOG" id="ENOG502S1DM">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NODULIN-RELATED PROTEIN 2"/>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB28046.1"/>
        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="34221" checksum="491D699C1F912E13" modified="2015-04-29" version="1">MAPKRSIGVPPPPPPSVPAGRLLSRQQSVGKLKKSSIMSSLFRELKTKLEGSRLQIKLSSRTKKQFGGSAGGKEGLAVFLRELTKRSPFFQQIEEDAQNHAKTILELKAAINSFQTKDMTELIKFQQHMEAILEVLTDENQVLAKFEDFPIKKLETIRAAAALYSKSNLVVSNLKNWEVKSPAAQLLNKFDCYFTKVKEELDAFERTKDEESRNFKSHGIDFDFNIFVTIKELMVDVSSNCMELVLKEWGETKGANDAEKKANKNLLWRAFKLAFRVYSFAGGNDERADKLAKELANERRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF12</accession>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G141000</name>
    </gene>
    <organism evidence="9 10">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_008G141000"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="Myb_TF_plants"/>
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    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999:SF6">
        <property type="entry name" value="MYB-RELATED PROTEIN P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB8-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
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        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
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        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="240" mass="27313" checksum="CC475A980BC1BB42" modified="2015-04-29" version="1">MGRAPCCEKVGLKKGRWTDEEDEILTKYIQVNGEGSWRSLPKNAGLLRCGKSCRLRWINYLRTDLKRGNFTAKEDETIVNLHSTLGNRWSLIASHLPGRTDNEIKNYWNAHLSRKIYRWAMKKNKSCCFNAQKDAISSSNKPMEVVPVIPSHSESEEERNMENISRPNSSSCNTEKETGSEDIWEPCSKDIMGSELLPPNDDLSLSGYGENSIEDDLNPITSCFVDDDLFGILRKFSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF46</accession>
    <name>A0A0D2RF46_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G008900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3 8">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cell membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF46"/>
    <dbReference type="STRING" id="29730.A0A0D2RF46"/>
    <dbReference type="Gramene" id="KJB69167">
        <property type="protein sequence ID" value="KJB69167"/>
        <property type="gene ID" value="B456_011G008900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776985"/>
    <dbReference type="eggNOG" id="ENOG502QQH2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWMGICA"/>
    <dbReference type="OrthoDB" id="689701at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33573:SF64">
        <property type="entry name" value="CASP-LIKE PROTEIN 2B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33573">
        <property type="entry name" value="CASP-LIKE PROTEIN 4A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB69167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="202" mass="21646" checksum="0D06963E77E33071" modified="2015-04-29" version="1">MNYLGVGISPGNVPVYHGTNPMVIERRVRIAELLLRCLICVLSVLTAFLVGTDSQVKEIFSIQKKARFTDMKALVFLVVANGVAAAYSLVQVVRCVVSMVKGSVLVNKPLAWTIFSGDQAMAYLNVAAVGAAAQSAVFAKLGQTELQWMKICNLYGKFCNQVGEGISMAVLASVCMVLQSGISAFTLFRLCGVNKAKGNSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF68</accession>
    <name>A0A0D2RF68_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G143200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF68"/>
    <dbReference type="STRING" id="29730.A0A0D2RF68"/>
    <dbReference type="Gramene" id="KJB49873">
        <property type="protein sequence ID" value="KJB49873"/>
        <property type="gene ID" value="B456_008G143200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764097"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB49873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="211" mass="24457" checksum="9AC75186C982ADB1" modified="2015-04-29" version="1">MVSLKLQKRLSASVLKCGKGKVWLDPNEVNEISMANSRQNIRKLVKDGFIIRKPTKIHSRSRARRMKEAKRKGRHSGYGKRKGTREARLPTKILWMRRMRVLRRLLRKYRESKKIDKHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLADQFEAKRAKNKASRERKFARREERLAQGPGGGEKPAAAQPAAAVQPAVGSKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKQ9</accession>
    <name>A0A0D2RKQ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G132400</name>
        <name evidence="8" type="ORF">Gorai_016646</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKQ9"/>
    <dbReference type="STRING" id="29730.A0A0D2RKQ9"/>
    <dbReference type="Gramene" id="KJB30176">
        <property type="protein sequence ID" value="KJB30176"/>
        <property type="gene ID" value="B456_005G132400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794088"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCEAILI"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0585885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="197" mass="22950" checksum="4B80C2C6E54EF8E0" modified="2015-04-29" version="1">MVSLKVQKRLAASLLNCGKGKVWLDPCEALLISMAKSRMDIRKLVKDNLIIKKPNISRSGWRYRKGKDVGNPRRKGYGKRKGTKEARLPSKLSWMRRARVLRRLLRKYREMKKIDKHLYHEFYMKAKGSVFKHKRALLEALHNKAKSEKDQMVHFDQVISIKAMGKLGSKETRVPRRKQCLSPPVEVIDVLNNAYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RN34</accession>
    <name>A0A0D2RN34_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G156700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RN34"/>
    <dbReference type="SMR" id="A0A0D2RN34"/>
    <dbReference type="STRING" id="29730.A0A0D2RN34"/>
    <dbReference type="Gramene" id="KJB72072">
        <property type="protein sequence ID" value="KJB72072"/>
        <property type="gene ID" value="B456_011G156700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778457"/>
    <dbReference type="eggNOG" id="KOG3106">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KLIYLAC"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00951">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB72072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="215" mass="25637" checksum="AAD2E264DB8C43E1" modified="2015-04-29" version="1">MNIFRLAGDMTHLFSVLVLLLKIHTIKSCAGISLKTQELYAIVFTTRYLDLFTTYISLYNTIMKLIFLGSSISIVWYMRHHKVVRRSYDKDQDTFRHYLLMLPCLLLALLINEKFTFLEVMWAFSLYLEAVAILPQLVLLQRTRNIDNLTGQYVLLLGAYRALYVLNWIYRYFTEENYVHWITWVSGIVQTLLYADFFYYYFQSWKNNVKLQLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNJ9</accession>
    <name>A0A0D2RNJ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_003G159300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNJ9"/>
    <dbReference type="STRING" id="29730.A0A0D2RNJ9"/>
    <dbReference type="Gramene" id="KJB20685">
        <property type="protein sequence ID" value="KJB20685"/>
        <property type="gene ID" value="B456_003G159300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789132"/>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFIFGQC"/>
    <dbReference type="OrthoDB" id="1506599at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090378">
        <property type="term" value="P:seed trichome elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="47"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="246"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB20685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="445" mass="50065" checksum="8AB008CAC6361DD3" modified="2015-04-29" version="1">MREIVHVQGGQCGNQIGSKFWEVICTEHGIDSTGRYNGDSELQLERINVYYNETSSGRFVPRAILMDLEPGTMDGVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAENCDCLQGFQVCHSLGGGTGSGMGTLLISKIREEYPDRTMLTFSVFPSPKVSDTVVEPYNATLSVHQLVENADECMVLDNEALYDICFRTLKLTTPSFGDLNHLISATMSGVTCCLRFPGQLNSDLRKLAVNLVPFPRLHFFMVGFAPLTSRGSQQYKALTVPELTQQMWDAKNMMCAADPRHGRYLTASAVFRGKMSTKEVDEQIINVQNKNSSYFVEWIPNNVKSTVCDIPPSGLKMASTFIGNSTSIQEMFRRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEDEEYEEYEEYEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQV2</accession>
    <name>A0A0D2RQV2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G213100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB73067"/>
        <property type="gene ID" value="B456_011G213100"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QUR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1915989at2759"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35696">
        <property type="entry name" value="ELECTRON CARRIER/IRON ION-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ELECTRON CARRIER_IRON ION-BINDING PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="381" mass="42527" checksum="E899044CCAA79413" modified="2015-04-29" version="1">MAASSPSASKSTSDATITTTTTTAAATTPLPHPPPPFQRMDTLPKTQRGLNKPKCIQCGNVARSRCPYRSCKSCCSKAQNPCHIHVLKSNSAFPEKSPTSSTPSSDQKSTQASSQVTPLRVPSFKQLSNAFAQFDNLQVRSKKHLTRKDAIALNDWRFSKLKEFKDRNIRIENDAFDRYIQNISLLEEVFSIKSIDEGSEEDEGSKPSSTLKEDETSVMISGLKLTLKSDPVRTDNARKRIKQIVDQGIEKLHKAEANDDDNDPDDQNKLDSRLNKVKSSRIERALVLCDIVDKLSKARNEEDLKSCLELKAQLYNQSIMSTDTEIEDPGALNKESTGTTIISRQVAYHPSPKMLTQIEIDQETLNKIEAHFTSQEQIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RS74</accession>
    <name>A0A0D2RS74_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Filament-like plant protein 7</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">B456_005G236700</name>
        <name evidence="5" type="ORF">Gorai_017383</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPP family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0586650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RS74"/>
    <dbReference type="STRING" id="29730.A0A0D2RS74"/>
    <dbReference type="Gramene" id="KJB32353">
        <property type="protein sequence ID" value="KJB32353"/>
        <property type="gene ID" value="B456_005G236700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32355">
        <property type="protein sequence ID" value="KJB32355"/>
        <property type="gene ID" value="B456_005G236700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32356">
        <property type="protein sequence ID" value="KJB32356"/>
        <property type="gene ID" value="B456_005G236700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795237"/>
    <dbReference type="eggNOG" id="ENOG502QRCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEVGMMR"/>
    <dbReference type="OrthoDB" id="1917992at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008587">
        <property type="entry name" value="FPP_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580">
        <property type="entry name" value="FILAMENT-LIKE PLANT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31580:SF8">
        <property type="entry name" value="FILAMENT-LIKE PROTEIN (DUF869)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05911">
        <property type="entry name" value="FPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="140"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="746"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB32356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0586650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1035" mass="116621" checksum="C8E7AEF5B2F9C92B" modified="2015-04-29" version="1">MDHKSWLWKKKTSEKTIVATDKVDVSVKRINEEERMEGGRDRIVKNLNENLASVLLDNHAKDDLMTKNVKMAPVLNAGQDMAEADAFALKKELHEALRQGKLANEKLTQSEVALKECMQQLNFVRDEQEQRIRDAVAKTSTEFEKEQKALQDKLTDTNRRLEELTIENSRLAKALLVKEKMIEDQEKQKSQSEAEFSALMAKLDLTEKENAFLKYEFHVLEKELEIRNEEMEYTRRSEDLAHKQHLQDVKNIAKLEAECQKLRLLLQKRLPGLAAVVKMKNEVEMLGKDKSETRRRKLNPTRDLIVRGSTADISPENPIKSINLLLEQLHNVEEENKNLKEIMTKKNAQIQSLGLICSQTSSRPTTEIGIQPKELFKGQKSMELVRSSTISSELSITSGFDIGSFDGTSSSCSWANALFPESARLDKRLKNPMDHKVFTVPEMRLMDDFVEMEKLALSDGKELVPFEQGHGTFSNTKQMQSKDVAGERSFDWLQVVLQAISKHKCISNRSSIEILEDIKIALGCSSLLNAPDVDKTACSMHPIEADGPHISGYIAWKSPNASPSTGSLSGASSVETSAEKTKKPLFQPDLNKSIGKIIELIEGIGLTSSDSSDSCLEKNQTPKQSPAHADYFVRVFQWKSSELSTVLQHFIRACNNMLNKRADLETFAEELSFTLDWIVNYCVTPKEASSARDKIKRHFGWNDSQSEKEVAYASHGVESDVTHISKEQTSLVDSFASLPDQSHSVIPPLEEENKRLKDDLKDMKTRLESETDKSEALMLQLQELKESIGSLQAELNMLKESKEMIEEQVENQKSINEDLDTQLTVAKAKLNEIFHKLSSLEVELEYKNSCCEELEATCLELQLQLESVAKKETPKYVMDQEGKQSQNGWEITAASVKLAECQETILNLGKQLKVLASPQEAVLFDKVFSNSKAATTAINNRRVNKRLSLRDRMLADNGSKVEDAENSTLLHSDNRKTSGLLLHASGSCLGSKNESANAGVMALAIVPSKKQGVGLLRKLLFRRKKGYTKKFRYQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTK8</accession>
    <name>A0A0D2RTK8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 4">Proteasome assembly chaperone 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G263900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Forms a heterodimer with PSMG1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the PSMG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTK8"/>
    <dbReference type="STRING" id="29730.A0A0D2RTK8"/>
    <dbReference type="Gramene" id="KJB32826">
        <property type="protein sequence ID" value="KJB32826"/>
        <property type="gene ID" value="B456_005G263900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795497"/>
    <dbReference type="eggNOG" id="KOG3112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKEHTGE"/>
    <dbReference type="OrthoDB" id="10260712at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10900:FF:000004">
        <property type="entry name" value="Proteasome assembly chaperone 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10900:FF:000005">
        <property type="entry name" value="Proteasome assembly chaperone 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="entry name" value="PAC-like subunit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016562">
        <property type="entry name" value="Proteasome_assmbl_chp_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12970:SF1">
        <property type="entry name" value="PROTEASOME ASSEMBLY CHAPERONE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010044">
        <property type="entry name" value="UCP010044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00019186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="281" mass="30973" checksum="5356CA53D29B0452" modified="2015-04-29" version="1">MEFVIEQGKQPHQECSTLLLPALSIGNVGQLAVDLLVSSMKAERIGYLDDPFVLPCVGNDAYGPIPCGDLALPLEAYESAFSRVALLQQRSPVVKGRMVEFAKNLANFAAASGKKHVVLLSSLDFGKWQKIDMSSGPQIYYLSSINPDGRDDNCEQLGWKRLQEYNPAQRCWKYLSMLAEGNTMLESNLPFEDELEDEDYYPSLPFAALFSCLKAKGLKVTCLLCYCSEGDNIQDAFHLAEAACRLLGLNPNAFPGNGSGGWVIPFSWHTVYGPPPDMSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTM6</accession>
    <name>A0A0D2RTM6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G270900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTM6"/>
    <dbReference type="STRING" id="29730.A0A0D2RTM6"/>
    <dbReference type="Gramene" id="KJB74077">
        <property type="protein sequence ID" value="KJB74077"/>
        <property type="gene ID" value="B456_011G270900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1703">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCFKEMT"/>
    <dbReference type="OrthoDB" id="25414at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09396">
        <property type="entry name" value="LIM_DA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000107">
        <property type="entry name" value="Protein DA1-related 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045218">
        <property type="entry name" value="DA1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022087">
        <property type="entry name" value="DA1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24209:SF7">
        <property type="entry name" value="PROTEIN DA1-RELATED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12315">
        <property type="entry name" value="DA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB74077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="519" mass="58132" checksum="D5B933610FF963C5" modified="2015-04-29" version="1">MAPPPPPPPPPPPSVVNHLSHPCIYGDFNNSYPERKSRIMKWLSKLFKSSSSGRRGGGSGGYNPHYLGEENMVVRAPVRMPDERPRSKKEQEELDHAIALSLSEGMGKPNGYNEWRRDNNYGGALPRGADNGGLNSSAYPPYGNMQYHPVGYRVCAGCHREIGYGNYLGCMGAYFHPNCFRCHSCGYPITEHEFSLSGRDPYHKTCFKELTHPKCDVCLQFIPTNGAGLIEYRCHPFWSQKYCPSHEHDNTARCCSCERLESWNVRYYSLEDGRSLCLECMESAIMDTGDCQPLYHAIRDYYEGMNMKLDQQIPMLLVERQALNEAIVGEKNGYHHMPETRGLCLSEEQTVTSILKRPRIGGRQLIGMRTQPQKLTRKCEVTAILVLYGLPRLLTGAILAHELMHGWLRLKGYRNLNPEVEEGICQVLSYMWLESEVLPGSSSRASTSAASSSSSSSKKGGKSNVENKLGEFFIHQIAHDASPAYGGGFRAANAAVNRYGLRQTLDHIRLTGEFPIVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S094</accession>
    <name>A0A0D2S094_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G135900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S094"/>
    <dbReference type="STRING" id="29730.A0A0D2S094"/>
    <dbReference type="Gramene" id="KJB56783">
        <property type="protein sequence ID" value="KJB56783"/>
        <property type="gene ID" value="B456_009G135900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTW8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF157">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="216"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB56783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="388" mass="42912" checksum="0CD43DCFDD2C621A" modified="2015-04-29" version="1">MSTPLEHDYIGLAETSSMERSSEKISSSSSSSIPSNIEDKTTNNPSLNLKETELRLGLPGSESPERKLSLFGKDLETNDKSNGFVGSPLKNLVSGAKRGFSDAIDGSNGKWVFAINGKSDVELGKGAVLASPRGGLDSKTNPQQVRTSVPVMKEVVGVPQSPKPVQDKKNLVPPVNEHASAPAAKAQVVGWPPIRSFRKNSMASNLAKNSDEAAGCLYVKVSMDGAPYLRKVDLKTYNNYREFSSALEKMFSCFTIGQCGSNGDGLSESRLMDLLHGSEYVLTYEDKDGDWMLVGDVPWEMFTDSCRRLRIMKGSEAIGLGIPSKSHGEMQEPELMQKTWKKHRKLYSTTLYTYVCAFRYYSLMYLVEVREKRDCIRQIMALKTYPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S4Q1</accession>
    <name>A0A0D2S4Q1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G172100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S4Q1"/>
    <dbReference type="STRING" id="29730.A0A0D2S4Q1"/>
    <dbReference type="Gramene" id="KJB36651">
        <property type="protein sequence ID" value="KJB36651"/>
        <property type="gene ID" value="B456_006G172100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799842"/>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQENGVW"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000009">
        <property type="entry name" value="oxysterol-binding protein-related protein 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3490:FF:000008">
        <property type="entry name" value="Oxysterol-binding protein-related protein 3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF164">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB36651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="51846" checksum="7DEDC812A2EAAE04" modified="2015-04-29" version="1">MAPNDPKQSGGFFASIASSISNFGSAMTKSVNGLMGYEGLEVVNPEGGTEDAEEEARRGRWKQEDRDSYWKMMQKYIGSDVTSMVTLPVLIFEPMSMLQKMAELMEYSYLLDLADECEDPYMRLVYTTSWAISVYYAYQRTWKPFNPILGETYEMVNHGGITFIAEQVSHHPPMSAGHAENEHFIYDISSKVKTKFLGNSIDIYPLGRTRVTLKRDGTVFDLVPPPTKVNNLIFGRTWVDSPGEMIMTNLTTGDKAVLYFQPCGWFGAGRYEIDGYVYNSAEEPKILMTGKWNESMSYQPCDSEGEPLPGTELKEAWKLADAPKNDKFQYTHFAHKINSFDTAPKKLLASDSRLRPDRYALELGDLSKAGFEKSSLEERQRAEKKNREEKGHKFTPKWFDFANEVAATPWGDLEVYQYNGKYTEHRVAIDGSSSSEEIDIKSTEFNPWQYEDLAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SCG3</accession>
    <name>A0A0D2SCG3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G329700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SCG3"/>
    <dbReference type="STRING" id="29730.A0A0D2SCG3"/>
    <dbReference type="Gramene" id="KJB60883">
        <property type="protein sequence ID" value="KJB60883"/>
        <property type="gene ID" value="B456_009G329700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB60883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="9032" checksum="F9CC18BB6C08654F" modified="2015-04-29" version="1" fragment="single">EVKPEVYEAHKFKLEPNLAKRAEHYFSENMRVRKGLEAWALGDLRAFGELMTASGLSSIKNYECGTIYIFCFLVALLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SCS0</accession>
    <name>A0A0D2SCS0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G022200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2SCS0"/>
    <dbReference type="Gramene" id="KJB39621">
        <property type="protein sequence ID" value="KJB39621"/>
        <property type="gene ID" value="B456_007G022200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0260">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEMITEP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10506">
        <property type="entry name" value="RNAP_IV_RPD1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000010">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040403">
        <property type="entry name" value="NRPD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF36">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE IV SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11523">
        <property type="entry name" value="DUF3223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="9">
        <location>
            <begin position="134"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB39621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1397" mass="157099" checksum="10449A90F183B584" modified="2015-04-29" version="1">MKSKPMTSIETDLSEEQEVLAATMTGIKFNVSGDEDNGNSIDWYPPMTFKISSKELSKKSTIVVEVSEDSLMMVRKRGRQALPADYWDFIPKDQQEEEDGLMKPRRRVLSHAQVHYLLKDVDPEFIKKFIQNVDSIFLNCFPVTPNSHRVTEITHRSSNSQRLIFDERTRLYKRLVDFRGVANELSSHVLECLKISKASYSALFSFLYLLFQEKPSNEDNELILALTRNKDPVSNMSGLRYMKNVLLGKRNDHCFRMVLTGNPSLKLSEIGIPCPVAERLQIAEQLNKWNEERLKACCNLRILEKGEICIRREGTLVRIHHNEKIRLGDIIYRPLNNGDIVLINRPPSIHQHSFIALSVKVLPVSSSVSINPLICSPFRGDFDGDCLHGYVPQSINTRVELSELVSLNRQLINGQSGRNLLSLSHDSLSAAYLVNGDGVLLNLYEMQQLEMFCPNRSPSPAIIKAPLLSNPVWTGKQLFSMLFPPELDYGFSPSDLVIRNGELITSSEGSSWFRDADGNLFESLIKNCRGKVLDFLHGAQEVLCEWLSMRGMSVSLLDLYLTPDSNSRKNMMDEIFYGLQETELTCNFKQLMVDSFCDFLAGNNEEIDGFVGFDFERMCYEKQRSAAVNQASVDSFKQVFRDIQNLSYKYANKDNSLLTMFKAGSKGNLLKLVQHSMCLGLQRSVVPLSFRFPPKLSCSEWNDLKSQGLTQSGDDSVESAKNFIPYAVIESSFMTGLNPLECFVHSVTSRDSSFSDHADLPGTLSRRLMFFLRDLCASYDGTVRNAYGGQVVQFSYGSDKGTSTATSFANEIQSQGSILPDGTGGQPVGSLSACAISEAAYSALDQPISLLETSPLLNLKRVLECGSRRRNSDQTMTLFLSDKLGKGRHCFEYAALEIKNYLEKLIFSDIVSTVLITYSPQKSTENCFNPWVCHFHVCKEIMKRRRLSVHSIIGSLQMHYANAKKLWKINLPDIQVTSKSCSHTDMPNKDDMFCITVTIVEPSKRSHIELDVILAIVLPSLLEAVVKGFPEIKKVQILWNDRFKVSKSHKTSPGELYLRVAVTGGFGKTKLWGMLMNDCLPIMDLIDWTRSHPDDINQFCSAYGIDSGWKFFLNNLKSAISDTGKTILNEHLHLVADCLSVTGEFVGLNSKGLRLRQEHAFVSSPFMQACFSNPSASFVKAAKKGVSDNLQGTIDALSWGRVPCIGTGAQFDILYSMKDEMITEPVDVYNLLGNIVGSQNQDVEFEVPQACNIKSEKYVSELMDALGDSAFERLKNIETKILREFLTLNDIQRLSRTLKDILHKSPIGHRLSGADWNSAMMALYFHPRRDEKVGSGAQEIKVGYHPEHKNSRCFLLARTDGAIVDFSYHKCVIGALEVIAPDKVQFYKSKWSQSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDZ9</accession>
    <name>A0A0D2SDZ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G042300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDZ9"/>
    <dbReference type="STRING" id="29730.A0A0D2SDZ9"/>
    <dbReference type="Gramene" id="KJB40016">
        <property type="protein sequence ID" value="KJB40016"/>
        <property type="gene ID" value="B456_007G042300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802101"/>
    <dbReference type="eggNOG" id="KOG2573">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKCAIAS"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000002">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="295"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB40016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="534" mass="59642" checksum="A84085C67031AE10" modified="2015-04-29" version="1">MALYLLFESSSGYALFHAQGLDEIGQNTEAVRNSVADLNRFGKVVQLTAFQPFESAIDGLNQCNSVSEGLMTDELRSFLELNLPKVKEGKKSKFSLGVAEPKLGSHISETTKIPCQSGEFVLELLRGVRLHFDKFIKDLKSGDLEKAQLGLAHSYSRAKVKFNVNRVDNMVIQAIFLLDTLDKDINSFSMRVREWYSWHFPELVKIVNDNYLYARVAKLIEDKSKLSEEHVPALTEILGDEDKAKEVVEAGKASMGQDLTPVDLINVQLFAQRVMDLAEYRKNLYDYLVTKMNDIAPNLASLIGEVVGARLISHAGSLTNLAKCPSSTLQILGAEKALFRALKTRGNTPKYGLIFHSSFIGRASSKNKGRMARYLANKCSIASRIDCFSERGSTVFGEKLREQVEERLEFYDKGVAPRKNIDVMKSAIESTQNKDTEMEVEPEEASAKKSKKKKSKTEDAPAAATNGDALEDGKSEKKKKKEKRKKEQEADEEDGKTNGVNEQDGTAKKKKKKSKDEAATNETTKKKKKKKSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKK2</accession>
    <name>A0A0D2SKK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G203100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SKK2"/>
    <dbReference type="Gramene" id="KJB31670">
        <property type="protein sequence ID" value="KJB31670"/>
        <property type="gene ID" value="B456_005G203100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794883"/>
    <dbReference type="eggNOG" id="KOG3178">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMACTAK"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000294">
        <property type="entry name" value="O-methyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012967">
        <property type="entry name" value="COMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08100">
        <property type="entry name" value="Dimerisation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase dimerisation" evidence="7">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="6">
        <location>
            <begin position="129"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="39307" checksum="38EBCB6317BDBFC4" modified="2015-04-29" version="1">MERIELDEAMLQGQADIWRYMYSFADAMALKSAVELRIADIIHSNGGATTLSQIASCINGGLTSPDITTLARIMRLLIRRKIFTVHHPSDGGDLLYDLTHSSRWLLHDSEQTLAPIVLMNNHTWQMAPWHYFSQCVKEGGIAFKKAYGCELWDLASRNPDLNKLFNDGMACTAKVVTNAILSSYKQGLSSIGSLVDVGGGTGGLISEIVKTYPHMKGINFDLPHVVSMAPTYNGVSHIGGDMFHAIPNADAVIMKWILHDWTDEECIKILRNCKKAIPRENGKVIIVEIILKEDGSGVFDDIGFVMDLVMFAHTNGKERTEAEWKKILEGGGFSHHKIINIPALVSIIEAYPDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SME7</accession>
    <name>A0A0D2SME7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyadenylate-binding protein</fullName>
            <shortName evidence="11">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G236500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SME7"/>
    <dbReference type="STRING" id="29730.A0A0D2SME7"/>
    <dbReference type="Gramene" id="KJB32340">
        <property type="protein sequence ID" value="KJB32340"/>
        <property type="gene ID" value="B456_005G236500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795234"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNGRMLN"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
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    </dbReference>
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        <property type="entry name" value="Polyadenylate-binding protein"/>
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    </dbReference>
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        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
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        <property type="entry name" value="Hud_Sxl_RNA"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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        <property type="entry name" value="PABP-dom"/>
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    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
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        <property type="entry name" value="RNA BINDING PROTEIN"/>
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        <property type="entry name" value="MLLE"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="HUDSXLRNA"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="114"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="308"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="13">
        <location>
            <begin position="547"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00022845"/>
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            <dbReference type="ARBA" id="ARBA00022884"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB32340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="647" mass="70815" checksum="4EAD89975BFBDFD5" modified="2015-04-29" version="1">MAHVQVQGQSGGVNNGSGGANNQFVTSLYVGDLDPSVTETQLYEYFNHIGQLLTVRLCTDLSTRRSLGYGYVNYGNPQDAARALELLNFTPLNGKPIRIMYSNRDPSLRKSGAGNIFIKNLDKGIDQKALHDTFSAFGNILSCKLATDSSGQSKGYGFVQFDNEESAQKAIEKLNGMLLNDKQVYVGPFVRKQERDTSTSKTKFNNVYVKNLSESTTDEDLNQTFGEFGPITSAVVMRDADGKSKGFGFINFENADDAARAVESLNGKKFDDKEWFVGKAQKKSEREAELKHRFEQTMKEAADKFQGANLYVKNLDDSISDEKLKELFSQYGTITSCKVMRDPSGISKGSGFVAFSTPEEASRALAEMNGKMVINKPLYVAQAQRKEDRRARLQAQFSQMRPLTMASSVAPRMPMYPPGGPGLGQQIFYGQAPPIFPPQPGFGYQQQLVPGMRPGGAPMPNFFVPMVQQGQQGQRPGGRRAGAVQQNQQPVPLMQQQMLPRGRVYRYPVGRGLPEVSMPNVPGGMLSVPYDMGSMPMRDAPLSQPIPIGALASALANATPEQQRTMLGENLYPLVEQLEPDAAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAMEVLRTVAQQQQQAGGAADQLASLSLNDNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNJ8</accession>
    <name>A0A0D2SNJ8_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G204500</name>
        <name evidence="6" type="ORF">Gorai_019160</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNJ8"/>
    <dbReference type="STRING" id="29730.A0A0D2SNJ8"/>
    <dbReference type="Gramene" id="KJB43526">
        <property type="protein sequence ID" value="KJB43526"/>
        <property type="gene ID" value="B456_007G204500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803814"/>
    <dbReference type="eggNOG" id="KOG1597">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIRAQDS"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009527">
        <property type="term" value="C:plastid outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20550">
        <property type="entry name" value="CYCLIN_TFIIB_archaea_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000045">
        <property type="entry name" value="Transcription initiation factor IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000050">
        <property type="entry name" value="Transcription initiation factor TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="137"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="4">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="324"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="512"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB43526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0590455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="528" mass="57165" checksum="95FB3D93677F2C4E" modified="2015-04-29" version="1">MKCPYCSAAQGRCATTSTGRSITECTSCGRVVEERQFQNHHLFHVRAQDTPLCLVTSDIPAPASAYQIHEDDPFEPTGFITAFSTWSLEPNPLFLRSSLSFSGHLAELERILELSSSSAPSATSSSTVVVDNLRAYMQILDVASILGLDCDISDHAFQLFRDCCSATCLRNRSVEALATAALVQAIREAQEPRTLQEISIAANVPQKEIGKYIKILGEALQLSQPINSNSISVHMPRFCTLLQLNKSAQELATHIGEVVINKCFCTRRNPISISAAAIYLACQLEDKRKTQAEICKVTGLTEVTLRKVYKELLENWDDLLPSNYTPAVPPEKAFPTTTIATGRSSVPRVDSIDLSSTADRDKQQDSKPIKPNDVSEAGLQARGKDDAENNGNSSGTHAAMLNRPPHFRQPWLQFGAPNVRTVGDKNQTTIGGDISEAQPSCPESEQKVDMPKIDTKGASSSLRPSQFSSSPASNVSTITWPFRSPASSGPSPNMPIVHPPKLPPGFAELKGSGTQNGSKVTNPSGDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSH1</accession>
    <name>A0A0D2SSH1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CobW C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G137900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSH1"/>
    <dbReference type="STRING" id="29730.A0A0D2SSH1"/>
    <dbReference type="Gramene" id="KJB66363">
        <property type="protein sequence ID" value="KJB66363"/>
        <property type="gene ID" value="B456_010G137900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1220.10:FF:000002">
        <property type="entry name" value="At1g80480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000778">
        <property type="entry name" value="GTP-binding protein YjiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00833">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW C-terminal" evidence="7">
        <location>
            <begin position="353"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB66363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="448" mass="49494" checksum="76E9F08B9E23B997" modified="2015-04-29" version="1">MATLSMDIATTFINFTTRCRRRSGIKTTVLPLFFKSSTINTRSLSSKPLPSSSLTVLSTSNFSKVNRCRRFSVAATATTTPQSEDSDVSTKIPPDTRIPATIITGFLGSGKTTLLNHILTADHGKRIAVIENEYGEVDIDGSLVAAKAAGAEDIVMLNNGCLCCTVRGDLVRMIAELVSKKKGKFDHIVIETTGLANPAPIIQTFYAEDQVFNDVKLDGVVTLVDAKHAGFHLDEVKPKGVVNEAVEQIAYADRIIVNKTDLVGEPEITSLVKRIRSINGMAHLKHTEFGKVDLEYVLGIGGFDLERLIESSVNDGAKEDHAHHHDHDHHHHHHHEHEHKHDHHHDHTHDPGVSSVSIVCEGSLDLEKANIWLGTLLLERSEDIYRMKGLLSVQGMDERFVFQGVHDIFQGSPDRLWGADEPRINKIVFIGKNLNAEELEKGFKACLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SU24</accession>
    <name>A0A0D2SU24_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G086100</name>
        <name evidence="2" type="ORF">Gorai_000585</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SU24"/>
    <dbReference type="STRING" id="29730.A0A0D2SU24"/>
    <dbReference type="Gramene" id="KJB34820">
        <property type="protein sequence ID" value="KJB34820"/>
        <property type="gene ID" value="B456_006G086100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7G7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RLEWVNS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34538">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34538:SF10">
        <property type="entry name" value="GENOME ASSEMBLY, CHROMOSOME: A06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB34820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0587456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="100" mass="11513" checksum="E1535FF274C6B4AD" modified="2015-04-29" version="1">MGAYVDFIGTLDWVNSYGKKQCKSLFWRAKAALKKTVKNHKRKQQCIFQYDPSSYALNFDDGCCRSDTGLEANMIGLNQFRDCSQCKNIMCVYHVPRVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXP1</accession>
    <name>A0A0D2SXP1_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G139800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXP1"/>
    <dbReference type="Gramene" id="KJB36080">
        <property type="protein sequence ID" value="KJB36080"/>
        <property type="gene ID" value="B456_006G139800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB36080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="85" mass="9724" checksum="249A3934832A988A" modified="2015-04-29" version="1">MVMPLIWPEVQVNGNKQQHQQQWQFDALQQPVWGREVCNNYITPENSLLSYDSSANSATLHANQTENGAMKSEEVPSVRLVERLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SY15</accession>
    <name>A0A0D2SY15_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G237900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SY15"/>
    <dbReference type="STRING" id="29730.A0A0D2SY15"/>
    <dbReference type="Gramene" id="KJB68308">
        <property type="protein sequence ID" value="KJB68308"/>
        <property type="gene ID" value="B456_010G237900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF29">
        <property type="entry name" value="ALA-INTERACTING SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB68308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="339" mass="39312" checksum="AF67987E8DE6A01A" modified="2015-04-29" version="1">MDTDRERHRARETAFYLFTQQSLPACKPVLTPGWVIAIFLFMGVIFIPVGLVTLRASHCVVEIVDRYDIDCVPEPSRMDKVSYIQDDSIPKNCSRFMKVHKYMKAPIYIYYQLDNYYQNHRRYVKSRSDKQLLDGQKYHDTSYCQPVESNNNRPIVPCGLIAWSLFNDTFEFIREGAELKVNRKNIAWKSDRGHKFGKNVYPFNFQNGTLIGGGKLNPEIPLSDQEDLIVWMRTSALPSFRKLYGRIEEDLDVDDVVVVNLMNNYNTYSFGGKKKLVLSTSSWLGGKNDFLGHACVFVGCSSLTLAIIFVLLHALWRHELFTLEQEKLFRVIRTRSTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1J5</accession>
    <name>A0A0D2T1J5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxypeptidase A inhibitor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G163800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1J5"/>
    <dbReference type="Gramene" id="KJB50324">
        <property type="protein sequence ID" value="KJB50324"/>
        <property type="gene ID" value="B456_008G163800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002264574" description="Carboxypeptidase A inhibitor-like domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7572" checksum="C0EEFD60F5FFBF7D" modified="2015-04-29" version="1">MEKFSFNLFIFAVILIFATHSEMMAEARGPVISCRCSKTEDCQGICAACPNYSCINNLCTCLSNAPPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T342</accession>
    <name>A0A0D2T342_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G209500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T342"/>
    <dbReference type="STRING" id="29730.A0A0D2T342"/>
    <dbReference type="Gramene" id="KJB50909">
        <property type="protein sequence ID" value="KJB50909"/>
        <property type="gene ID" value="B456_008G209500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0418">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14312">
        <property type="entry name" value="UBA_II_E2_UBC27_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000037">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041974">
        <property type="entry name" value="UBC27_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="2"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB50909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="201" mass="22087" checksum="D4149016B17FA4EB" modified="2015-04-29" version="1">MIDFARVQKELQECSREKDSSGIRVSPKSDNLARLTGIIPGPLGTPYEGGSFEIDITLPVIGFYFADGYPFEPPKMKFVTKVWHPNISSQSGAICLDILKDQWSPALTLKTALLSVQALLSAPEPDDPQDAVVAQQYLREYQTFVGTARYWTESFAKASSLGVEEKVQRLVEMGFPDGLVRSTLEAVGGDENLALEKLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8E7</accession>
    <name>A0A0D2T8E7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G186100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T8E7"/>
    <dbReference type="Gramene" id="KJB50756">
        <property type="protein sequence ID" value="KJB50756"/>
        <property type="gene ID" value="B456_008G186100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIDHHSG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="185" mass="21847" checksum="89DEAAC3E27B77E8" modified="2015-04-29" version="1">MHEERITILFENNEAYRRMITDISGNVNNTLIGFEAINQKFEAGYSKYKHCVEETSKELRIAKHRVGETKSEKKQLMNEMTNMIEQLKDQKEKESTLREQVEKLQIKANKEENEKENLMKSVKQLENKVELLERAIKEKDEGILGLGEEKREAIRQLCMWIDYHRSRCDDLKEILSKSNKAQRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCZ3</accession>
    <name>A0A0D2TCZ3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G239700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2TCZ3"/>
    <dbReference type="STRING" id="29730.A0A0D2TCZ3"/>
    <dbReference type="Gramene" id="KJB73583">
        <property type="protein sequence ID" value="KJB73583"/>
        <property type="gene ID" value="B456_011G239700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKTNRSE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="137" mass="15585" checksum="25825541D3761784" modified="2015-04-29" version="1">MLNDPLEENIANMYKTEGANTRKLLGTRRKNNPYAGGVFEVDIHFPPQYPFEPPEVVLRTKIFHPNIDGNGSIGLDILKDRWSTNLTISQVLHSICSLLKNPNPDAPLVPEIAHMYKTNRSEYDTTTRSWTEKYAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TES0</accession>
    <name>A0A0D2TES0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">DUF4228 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G162100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TES0"/>
    <dbReference type="STRING" id="29730.A0A0D2TES0"/>
    <dbReference type="Gramene" id="KJB55129">
        <property type="protein sequence ID" value="KJB55129"/>
        <property type="gene ID" value="B456_009G162100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771090"/>
    <dbReference type="eggNOG" id="ENOG502RXVG">
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    </dbReference>
    <dbReference type="OMA" id="MIRSCIS"/>
    <dbReference type="OrthoDB" id="1856818at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB55129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18752" checksum="E40BAC7327B403D9" modified="2015-04-29" version="1">MKNSIRCCISCILPCGALDVVRIVHSNGLIEEISGSIMAAEIMKAHPKHVLKLPSSPSHDGMLSKVVVVPPDAKLQCGKIYFLLPLPPTTMKKRGQNANHNGRQHRQSGSTSNTKNNTILVANLSTSDEHCFSEVLSDKLSTERDRRRRGRVGMWRPHLESISETLNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGV7</accession>
    <name>A0A0D2TGV7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD repeat-containing protein 75 second beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_009G004800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGV7"/>
    <dbReference type="STRING" id="29730.A0A0D2TGV7"/>
    <dbReference type="Gramene" id="KJB53781">
        <property type="protein sequence ID" value="KJB53781"/>
        <property type="gene ID" value="B456_009G004800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767367"/>
    <dbReference type="eggNOG" id="KOG1963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WILNTRI"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057644">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45176">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN / WD-40 REPEAT FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45176:SF1">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23769">
        <property type="entry name" value="Beta-prop_WDR75_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="WD repeat-containing protein 75 second beta-propeller" evidence="8">
        <location>
            <begin position="397"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB53781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="812" mass="88771" checksum="73EEBF1839912690" modified="2015-04-29" version="1">MMRGGRSLVSSPPAFSNDAKKLLVCTSNTVSVFSTVTGLLITSLEGHTALVTSVIVVPPSNPAAKVLCYCWTASLDGTIRYWDFSLPELMKTIDIRMPIFSMVIPSFLDVPAEENGKHQDLFAYVSIEDAKETQERTKASRRQIRKCNLSKSRLVGRLILGETRKPEVLTVSPSGKFFGIRNKCKLHIWKVLDQGSERAAVRKITLHHTKKITVIAFHPTQRIIAAGDVTGRILTWRGFGNRAFAASNGVADQKLINVQEDKPGVRDNDDADSCSTWHWHSAEVNVLSFSSDGSYLYSGGKEGVLVVWQLDTGKKKFLPRIGSPLLYFIDSPDPTLSSISCADNQIHLLKMPSMGILKTISGIKAPCCYPDMYEGLGNGIAFDQTAGIVAVRTENYCIQFYSLFDDRGVSEVQVCERNHQPGDDVTVIVTSVALSIDGSLMSTSEVKLAEEGIGGLVCLKFWDAGSQNKEFSLSTIVYEPHRDAGISAVKFHPSGNMVVSSSFGGDFKVWKCNHDVIQNDQMRQNFSWTCHAVGSYKKKPMTAAAFSADGSVLAVAAETLITLWNPYKNVLLAVLGETLTPIVNLSFVGKSDNLVAASCGSNPQLSVWNMSKLSLSWSYKLHIEAVASAVDLSSFAALVLLPESSKKTTFKGMDGVILLFNATDPVPTVIWSVRKAKGGALCFVQVSPSSVEEISIDGKAPEVLLAYMNGDHEYVLFDPYCKDAREVSVSQKEGLAAHDHKGQAGQYGYASIYGELPEFDRKRPEAPWVPSFPSDRPWETIFSGSSHNLPPLTKLCSAFLESLLEKRTAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJ93</accession>
    <name>A0A0D2TJ93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G135200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJ93"/>
    <dbReference type="STRING" id="29730.A0A0D2TJ93"/>
    <dbReference type="Gramene" id="KJB56770">
        <property type="protein sequence ID" value="KJB56770"/>
        <property type="gene ID" value="B456_009G135200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56774">
        <property type="protein sequence ID" value="KJB56774"/>
        <property type="gene ID" value="B456_009G135200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769368"/>
    <dbReference type="eggNOG" id="KOG4673">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWESVER"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47347">
        <property type="entry name" value="GOLGIN CANDIDATE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47347:SF2">
        <property type="entry name" value="GOLGIN CANDIDATE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="860"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="79"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="473"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="556"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="659"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="882"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="934"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="273"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="802"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB56774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="977" mass="110384" checksum="7C1359EF05BD11D1" modified="2015-04-29" version="1">MYIELKGKKREKRMAWFSGKVSLGGFPDIAGAVNKFQESVKNIEKNFDNALGFEEKSESNSNEASGLWPSDRKALFDPVMSFMGQKGEENAVESSGKLESSQDPPKAVEKEEAETGSSTYPHEKTSVEDDKAAVKLEKENKHSEAVERADTAISDSGKAESEPEPVSTEPSETTFQNVGSSDSPDTEQQKESFVMVISDDSDSKEAKLDNAEVDQVEDAEPVPAKSSDAVDILESKDEQKTYTEEISDKSSPVKSEESSDRQDYAGACPEESVLSNSHSISVEETNSDQEFPLPNVLPSYEAQGTVSESAFVGNDANTEKGEVNEQANDSETDVKEEMHMSSATIMPASVDSMHELEKVMMEMKMMESALQGAARQAQAKADEIAKLMNENEQLKAVIEDLKRKSNEAEMESLQEEYHQRVSTLERKVYALTKERDTLRREQNKKSDAAALLKEKDEIIKQVMAEGEELSKKQATQESLIRKLRAQIRELEEEKKGLTTKLQVEENKVESIKKDKTATEKLLQETIEKHQVELAAQKDFYTNALNAAREAEALAEARANNEARTELESRLREAEERESMLVQTLEELRQTLSRKEQQAVFREDMLRRDIEDLQKRYQASERRCEELITQVPESTRPLLRQIEAMQETTSRRAEAWAAVERSLNSRLQEAESKAAAAEERERSVNERLSQTLSRINVIEAQISCLRAEQTQLSRSLEKERQRAAEQRQEYLAAKEEADTQEVRANQLEEEIRELRRKHKQELQDALVHRELLQQEVEREKAARADLERTVRVQSTELAPIARHNSTLENGSLSRKLSTTSSMESMEESYYLQASLDSSDGFSEKRNIGETALSPLYMKSMTPSAFESALRQKEGELASYMSRLTSLESIRDSLSEELVKMTAQCEKLKAEAATLPGIRTELEALRRRHSAALELMGERDEELEELRADIVDLKEMYREQVNLLVNKIQRMNSSAGNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJS9</accession>
    <name>A0A0D2TJS9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G226400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJS9"/>
    <dbReference type="STRING" id="29730.A0A0D2TJS9"/>
    <dbReference type="Gramene" id="KJB43960">
        <property type="protein sequence ID" value="KJB43960"/>
        <property type="gene ID" value="B456_007G226400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HINIRHV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040256">
        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF99">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="13043" checksum="84C9084280E3047D" modified="2015-04-29" version="1">MKIIRVRHNCVHAIRHINIRHVGPWVIFRQYLTVRPWSLGFLVEQNGIDTQVVWVRLPGLSEGYYTSFILKAIGQVTGSVIKINGNTVHAKIGRFAHMTICVDLKKPLLSKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TMQ7</accession>
    <name>A0A0D2TMQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G112400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the 19S regulatory particle (RP/PA700) lid subcomplex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The RP/PA700 complex is composed of at least 17 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TMQ7"/>
    <dbReference type="STRING" id="29730.A0A0D2TMQ7"/>
    <dbReference type="Gramene" id="KJB76918">
        <property type="protein sequence ID" value="KJB76918"/>
        <property type="gene ID" value="B456_012G112400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1556">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHRAMAC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000013">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="17"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00064920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB76918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="291" mass="32943" checksum="1BE2F928A904E462" modified="2015-04-29" version="1">MDVIKTQQISSRPIEKVIVHPLVLLSIVDNYNRVAKDTRKRVIGVLLGTSFKGTVDVTNSYAVPFEEDEKDPSIWFLDHNYHESMFSMFKRINAKEHVVGWYSTGPKLRENDLDIHRLFHNYVPNPVLVIIDVQPKELGIPTKAYYDVEEVKENATQKSQKVFVHVPSEIAAHEVEEIGVEHLLRDVKDTTISTLATEVTGKLTALKGLDARLREIRGYLDLDVFNLLPNLKVNDLIKAFAVQTNDMMLVINLSSLIRSVIALHNLINNNMLNKEHEKAEDAKPATVQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPB1</accession>
    <name>A0A0D2TPB1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G125700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPB1"/>
    <dbReference type="STRING" id="29730.A0A0D2TPB1"/>
    <dbReference type="Gramene" id="KJB56571">
        <property type="protein sequence ID" value="KJB56571"/>
        <property type="gene ID" value="B456_009G125700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2TQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCTEFAG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31677:SF75">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF084"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="145"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB56571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="274" mass="29593" checksum="1B3DF2E8DBF5BC3E" modified="2015-04-29" version="1">MVDFRSLQAVPFFDTPQTSEASWPCDRPAGSSQFPSCSSMIAPTYFYKRNYPPVCTEFAGVLSLDGFDKNRENAVETTIESGPEMPPVLDGIAVVVGQHVLFGNKANPTTSNRSSDGDRPGFISVSQRFGANKRDLGSSVSVQKSYRGVRKRPWGRWSAEIRDRVGRCRHWLGTFDTAEEAARAYDAAARRLRGSKAKTNFEIPSVLPALASPSTSSSSSEAKKVKGKAKTVRKCAVVTSVDQLFSSDSSFGGNEGKGKSGLVLTTSKATTSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPQ8</accession>
    <name>A0A0D2TPQ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein CutA, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G231100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CutA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPQ8"/>
    <dbReference type="STRING" id="29730.A0A0D2TPQ8"/>
    <dbReference type="Gramene" id="KJB58929">
        <property type="protein sequence ID" value="KJB58929"/>
        <property type="gene ID" value="B456_009G231100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769481"/>
    <dbReference type="eggNOG" id="KOG3338">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYTTFPD"/>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000008">
        <property type="entry name" value="Protein CutA 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
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    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB58929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19901" checksum="458EE52DCAC44114" modified="2015-04-29" version="1">MASTLCCRASLLVSSNATRRRFQLLASFPTLSSSSSYLKMGCVQPLPFVRLLRSKFSTRAPDKTVPVVKMEASSNTVPSIVVYVTVPNRDAGRKLADSIVKEKLAACVNIVPGVVSVYEWEGKVNRDPEELLIIKTRQSLLPALTEHVKANHEYDVPEVIALPIGGGSAEFLEWLKNSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1B7</accession>
    <name>A0A0D2U1B7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G143200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1B7"/>
    <dbReference type="Gramene" id="KJB81398">
        <property type="protein sequence ID" value="KJB81398"/>
        <property type="gene ID" value="B456_013G143200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781903"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLHEPIY"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1244">
        <property type="entry name" value="TRICHOME DIFFERENTIATION PROTEIN GL1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="57"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="57"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB81398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="246" mass="28756" checksum="AEB9DB8048E5B390" modified="2015-04-29" version="1">MVRQPYLKKGTWSHDEDQKLIAYIRKYGIWNWNEMPKFAGLQRSGKSCRLRWMNYLRPNIRRGNFSREEEETIIHLQKTLGNRWSAIAARLPQRTDNDIKNYWNTRLKKRVMGEKKNPSSATTETKSSMEENSSDADSSMMVDILLDYQIPTMDDFPELAADTTISLSDCNLSVAVDDHYNMAMDNNLVSSENYWEIENLWGQSLTMEGLDCEVMSPNSQLWLHEPIYACDSYYDPVVELWVNPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U556</accession>
    <name>A0A0D2U556_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G218800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF213">
        <property type="entry name" value="OS01G0232200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
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        <property type="entry name" value="GPROTEINBRPT"/>
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    </dbReference>
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        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
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            <begin position="230"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="460" mass="52342" checksum="86E1760EFB4AA39E" modified="2015-04-29" version="1">MEFHGRKTGHCYMDNESNPLQSPSRLSIRTHLDMYDQDPQFSPGRPPSPRSSASALQLMLPPGSPETPWTLSPLQTPSPALLYHCVASLHRQDGNIHSIAISKGLVFTVSDSKRIRVWRQPECIERGCIKTSSGEIRAILAYGNKLFTAHRDCKIRIWNYTVSDSFGYKKISTLPKRSSFLLFPKTSSQQHKDCVSCMAYYHAEGLLYTGSYDRTVKAWRLVDNKCVDSFVVHESKVNAIVVNQDDGCVFTCSSDGSVKIWRRLYRENSHTLTMTLRFQQSPVNAMAISSTFSNCFLYSGSSDGTVNFWEKEKTSGRFNHGGFLQGHRFSVLCLVAIEKLIFSGSEDTTIRVWRREEGSCFHECLAVLDGHRGPVKCLAACLQMEKIVMGFLVYSASLDQTFKVWRVKVMPEEQTCFDFADRNDSKTKTKTEYEMSPVLSPSWVEKKLRDFNLDKPWNQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U699</accession>
    <name>A0A0D2U699_GOSRA</name>
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        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31719:SF123">
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    </dbReference>
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    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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        <location>
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            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB51015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="183" mass="21506" checksum="559AE15411780171" modified="2015-04-29" version="1">MEDQVAGNEDYGDKLPVGFRFLPTDVEFVTHYLINKVIYNPFSSFIFQEINATELYTKSPKNSVQFCNGEREWFFFIYMDMNIDNMHNKAIEKGGDELGFWQSMGDRKCVKDTNGNTLATKITFLYFSGSPSHRKKTHWRIDEFRLPIQFYTLHNSKKIEGNNFTKEKWAAGRLTRGRDYTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6H5</accession>
    <name>A0A0D2U6H5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">IBH1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_013G246700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2U6H5"/>
    <dbReference type="Gramene" id="KJB83418">
        <property type="protein sequence ID" value="KJB83418"/>
        <property type="gene ID" value="B456_013G246700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783373"/>
    <dbReference type="eggNOG" id="ENOG502SB35">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEGQVAK"/>
    <dbReference type="OrthoDB" id="658598at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11444">
        <property type="entry name" value="bHLH_AtIBH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044549">
        <property type="entry name" value="bHLH_AtIBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044660">
        <property type="entry name" value="IBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059002">
        <property type="entry name" value="IBH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124:SF42">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124">
        <property type="entry name" value="TRANSCRIPTION FACTOR IBH1-LIKE 1"/>
        <property type="match status" value="1"/>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Rambani A."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
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                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Reddy U.K."/>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2 8"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBR0"/>
    <dbReference type="STRING" id="29730.A0A0D2UBR0"/>
    <dbReference type="Gramene" id="KJB66314">
        <property type="protein sequence ID" value="KJB66314"/>
        <property type="gene ID" value="B456_010G134900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="9">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB66314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="151" mass="16852" checksum="7D68457602E57627" modified="2015-04-29" version="1">MKSLVPNCPPLFFSQPSPPAPIHLQSGTNPPPALHGSTHFPHFPFSFFHKSLTPCPTALLPFFLNIHLRHQSTSGPAPIHLRSSTAPPISRIRAYELSKKEGKVGTPERPLSDLGLLSYRGYWTRVLLDILKKYKRNISIKVSLPKAVLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UCB3</accession>
    <name>A0A0D2UCB3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G109800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UCB3"/>
    <dbReference type="Gramene" id="KJB65711">
        <property type="protein sequence ID" value="KJB65711"/>
        <property type="gene ID" value="B456_010G109800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB65711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="86" mass="9778" checksum="1CA7601F370F3688" modified="2015-04-29" version="1">MQVVRALEDNISLPYLEEGSRFWKNSFNSTSSATFIQNAQLCNNNDSFSETTSEYGLNPSGSTTEIEITPNYSISKQPEYDLNRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEY4</accession>
    <name>A0A0D2UEY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ACT domain-containing protein ACR</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Protein ACT DOMAIN REPEATS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G188200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Binds amino acids.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEY4"/>
    <dbReference type="STRING" id="29730.A0A0D2UEY4"/>
    <dbReference type="Gramene" id="KJB67339">
        <property type="protein sequence ID" value="KJB67339"/>
        <property type="gene ID" value="B456_010G188200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772527"/>
    <dbReference type="eggNOG" id="ENOG502QWKY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITKANTG"/>
    <dbReference type="OrthoDB" id="496180at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040217">
        <property type="entry name" value="ACR1-12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096:SF16">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31096">
        <property type="entry name" value="ACT DOMAIN-CONTAINING PROTEIN ACR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT" evidence="3">
        <location>
            <begin position="100"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB67339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="31917" checksum="15DF90C8B100C13D" modified="2015-04-29" version="1">MAVAMASAANCGVYFSSNTNKLNFPVFDFKNHSWSAAFVTTPPNILEKRSVRLSFSMMGIIPRATSSATAVESDGSFQDTDTVPTPKVIIDQDSDPDATVVEITFGDRLGALLDTMNALKNLGLNVSKANVYLDSSGKHNKFAITKASTGRKVEEPELLEAIRLTIINNLLEYHPESSSQLAMGATFGVEPPKEKVDVDIATHIRVDDDGSDRSLLYVETADRPGLLVDLVKIITDINITVESGEFDTEGLLAKAKFHVSYKGKAIIRPLQQVLANSLRYFLRRPTTEEASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHV9</accession>
    <name>A0A0D2UHV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Myb/SANT-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_010G235700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHV9"/>
    <dbReference type="STRING" id="29730.A0A0D2UHV9"/>
    <dbReference type="Gramene" id="KJB68274">
        <property type="protein sequence ID" value="KJB68274"/>
        <property type="gene ID" value="B456_010G235700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772866"/>
    <dbReference type="eggNOG" id="KOG4282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAPRSHY"/>
    <dbReference type="OrthoDB" id="2019351at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000104">
        <property type="entry name" value="trihelix transcription factor ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044823">
        <property type="entry name" value="ASIL1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044822">
        <property type="entry name" value="Myb_DNA-bind_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31307:SF4">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR ASIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13837">
        <property type="entry name" value="Myb_DNA-bind_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb/SANT-like DNA-binding" evidence="8">
        <location>
            <begin position="138"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="59"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="276"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB68274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="453" mass="50357" checksum="06F5623492691670" modified="2015-04-29" version="1">MQCLLHRRRHFPSRPTLLSVPSTDNKKTNETENKMPKKKNSRRNPKFFPFFSSEIIEFSGSQMEEDEEIQSYPSVAATGSSSPSSPSPASNSRITVTVAAAPPPNSPPTDEPHEHEKAIVLALPPPQKPKSNGGGREDCWSEGATEVLIDAWGERYLELSRGNLKQKHWKEVADIVSSREDYTKTPKTDIQCKNRIDTVKKKYKLEKAKVAAGGGPSKWVFFEKLDQLIGPTAKVSASTTAAVSGGGGSSSGGSADFLSKVPMGIPVGIRSSLNPFRVSQVRQQQQQQQQQQQQEKQPRMVVLKNQRKQGPVDMDSEDDDDDGDDDADSFDSLPPPPTGKRARRVVHNKSVNAGEKRRKWGNSVKELTQAILRFGEAYEQAETAKLQQVVEMEKQRMKFAKELELQRMQFFMKTQLEISQLKQGKKGVGIFNSGNHHSKANNNNNNNNSDSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UI19</accession>
    <name>A0A0D2UI19_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_010G205200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UI19"/>
    <dbReference type="STRING" id="29730.A0A0D2UI19"/>
    <dbReference type="Gramene" id="KJB67676">
        <property type="protein sequence ID" value="KJB67676"/>
        <property type="gene ID" value="B456_010G205200"/>
    </dbReference>
    <dbReference type="OMA" id="MPQTQHE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB67676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15883" checksum="933AA2324A01BEBD" modified="2015-04-29" version="1">MRSTIFDQRIADSLKTWHHTAKENTKHDKLSKNTTPFSSKPATPSHGMSPVHPLHGYPRKSEESGHTSLTHSNFENDRWDPVDMFTNSSSHRDIDVPDVSRGGLQSERREVADVTVQEFRALEMASTSPHMPQTQHEIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJB3</accession>
    <name>A0A0D2UJB3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G224300</name>
        <name evidence="4" type="ORF">Gorai_008312</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJB3"/>
    <dbReference type="Gramene" id="KJB68081">
        <property type="protein sequence ID" value="KJB68081"/>
        <property type="gene ID" value="B456_010G224300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKTTDQF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000470">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g66520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001203">
        <property type="entry name" value="Putative pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF492">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="78"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="311"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="412"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="447"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB68081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0598555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="655" mass="74058" checksum="5071B8F45E16A5F2" modified="2015-04-29" version="1">MASKSLAHFTHHLDPPFSLIEFSKSMDQLKQIHSQAIASGLIETPIFLNKVISFCCMNKFGDMDHALKLFDQIPEPKTVFLWNTMIKGYSRIHSPKHGISMYLNMLRQNVKPDNYTFPFLFKGFDRNVGFSCGKELHCHVVKFGFGSNVFVQNALIHIYSLCGQMKMARWVFDISCKTDVITWNVIITGYNKTKQYNETSKLFDEMVKNGVVPSSVTLVSLLSACSKLRDLKIGELVHEYIGKCEIKPNLILENALMDMYSACGEMDVAIGIFDRMKTRDVISWTTIVSGFINKGEIDLARTYFDQMPEKDYVSWTAMIDGYIRVNCFKEALILFREMQASNIQPDEYTMVSILTACAHLGALQLGEWIKAYIDRNKVKNDVFVGNALIDMYFKCGSVAKAKRVFFEMPRRDKFTWTAMIVGLAINGHGEEALSMFFEMLRASIKPDEITYIGVLCACSHAGLVNEGRKFFASMTAEHGVEPNVAHYGCMVDLLGRAGHLQQACEVIKNMPMKPNEIIWGALLGACRVHKDVGIAKMAAKNILELDPQNGAVYVLLCNIYAYCKKWDSLHELRESMMHRGIRKTPGCSLIEMNGVVHEFVAGDRTHPRSKEIYLKLDNMTRDLKLAGYSPDTSEVFLDIGEEDTSIAKGWCWLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNB1</accession>
    <name>A0A0D2UNB1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G030900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNB1"/>
    <dbReference type="STRING" id="29730.A0A0D2UNB1"/>
    <dbReference type="Gramene" id="KJB69564">
        <property type="protein sequence ID" value="KJB69564"/>
        <property type="gene ID" value="B456_011G030900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69566">
        <property type="protein sequence ID" value="KJB69566"/>
        <property type="gene ID" value="B456_011G030900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQSY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRMEEHH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF5">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="10">
        <location>
            <begin position="142"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="511"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB69566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="687" mass="75235" checksum="623E716E1E59C1C4" modified="2015-04-29" version="1">MGCLIDLNATEEDETPSSCSLSPSSVLSASGFSSSVCLELLHACVGPLISLPKKGSVVVYFPQGHLEQAPEFSGLASVYDLPPHVFCRVLDVKLHAEGATDEVYAQVSLVPDNEQTEQKLQEVDGEDEDAEADMKLATPHMFCKTLTASDTSTHGGFSVPRRAAEDCFPPLDYDQQRPSQELVAKDLHGVEWRFRHIYRGQPRRHLLTTGWSAFVNKKKLVSGDAVLFLRGEDGELRLGIRRAAQIKNGASFLSLCSKQLNRSTFADAVHAISMKSVFSIYYNPRASSSEFIVPVCKFRKSLDRSFSVGMRFKMRFETENAPERSCRSSGLITGTSDLDPVRWPGSKWKCLSVRWDDIDANKHGRVSHWEIELSGSISSSNCLLSPCSKRNRVGLPSGKPEFMVPDGIGAPDFGEPLRFQKVLQGQEILGFSTLYNSADSHNMHWSEIRRCFPGSNGSGIATIGNVGRDPPLNPVISYKGVGFGESFGFHKVLQGQEIFLSSLYRRGSTMEETRGNDSAGLPNVGQMSGTRSGWSSSMQGYNTHSPVQPSAQVSSPSSVLMFQQASNPVPNFNPTRNFNQEMERGVSSFRVPETYGAKLLSSSISEHDSQPLAAQPSFGTNQELASCKSSCRLFGFSLTEGDLDATKEDNMVHATLSLGRGSLLPCIGENFHPNPPAVASTVWKQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UU21</accession>
    <name>A0A0D2UU21_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G163600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GST superfamily. Tau family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UU21"/>
    <dbReference type="STRING" id="29730.A0A0D2UU21"/>
    <dbReference type="Gramene" id="KJB72174">
        <property type="protein sequence ID" value="KJB72174"/>
        <property type="gene ID" value="B456_011G163600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774942"/>
    <dbReference type="eggNOG" id="KOG0406">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPNNPLL"/>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03185">
        <property type="entry name" value="GST_C_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03058">
        <property type="entry name" value="GST_N_Tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000012">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000014">
        <property type="entry name" value="Tau class glutathione S-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045074">
        <property type="entry name" value="GST_C_Tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045073">
        <property type="entry name" value="Omega/Tau-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE, GST, SUPERFAMILY, GST DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11260:SF778">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01152">
        <property type="entry name" value="Main.3:_Omega-_and_Tau-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="86"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB72174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="224" mass="26103" checksum="8971522A4DBCFF9C" modified="2015-04-29" version="1">MAEVKLHGFWSSPFSHRVIWALKIKGVNYEYIEEDLSNKSELLLKYNPVYKKIPVLVHGGKPIAESLVILEYIEETWPNNPLLPIDPYDKAIARFWIQFGVDKGPIFSDFFRSTGGEEQEKTTKELLEALKIIEEQALGDKKFFGGNAINLVDISYGMIAYWFKIMEEVIEVNVLEPNTLPRLCQWAQNFMEVPVIKENIPDRHKVFAYLRHIRQKLLLEHLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UVC3</accession>
    <name>A0A0D2UVC3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G179700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UVC3"/>
    <dbReference type="STRING" id="29730.A0A0D2UVC3"/>
    <dbReference type="Gramene" id="KJB72456">
        <property type="protein sequence ID" value="KJB72456"/>
        <property type="gene ID" value="B456_011G179700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDEELMH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF58">
        <property type="entry name" value="OS02G0131700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="14"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="263"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB72456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43513" checksum="692D35B85DFC0117" modified="2015-04-29" version="1">MATPCPLPVTAAQVGIYFVERYYQVIIQQPHLVHQFHSDASTMVRVDGSHRETAAAMLQIHALVMLLNFTGIEIKTACSLESWNAGVLVMVSGSVLVKDFCSRREFVQTFFLAPQEKGFFVLNDIFHFIEEQQIQHHPADIFVALTYNIVLFVVPGYLLGGDIQRREFVAPVDVKENGPVDNYTLSEQLQQAPESESVVDKSSLRVAKGQSAPSVAPQVSVSKNPLPASDWDHAPQHTAQQPVLSSNVVEMSGADMVDEISPIENLPSTVFESEIEEEFKKFGDISPDGVVIRSRKDVGVCYAFVEFQDMSSVRNAVMAGTAQVAGRQVYIEERRPNSYIPSRGGRMGRGRGSYPTEAPRGRFGTRSYGGGGAYNGSERDHSRSRGNGFYRQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UWU3</accession>
    <name>A0A0D2UWU3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_009G314000</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UWU3"/>
    <dbReference type="Gramene" id="KJB60590">
        <property type="protein sequence ID" value="KJB60590"/>
        <property type="gene ID" value="B456_009G314000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ELFSINY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000432">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000288">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000299">
        <property type="entry name" value="Piriformospora indica-insensitive protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000627">
        <property type="entry name" value="Probable leucine-rich repeat receptor-like protein kinase At2g33170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF592">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 24" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253812" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="29"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="656"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="711"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1035" mass="113687" checksum="62F899C283202E6C" modified="2015-04-29" version="1">MEKSRIKFLLCIVAVITLASMSFKPAMAAMGNETDRLALLALKDELLGGSHGGPLLSWNASLHFCEWQGVGCGQQQQRVISLSLPGLKLGGIISPSIGNLSFLREANLFNNSLKGNIPREFGHLRQLRSLNLSRNNLQGNIPVELNNCSNLQFLNLSDNSFTGKIPFQLGDTMKNLIKLSLARNDFIGTIPSSLGNLSSLDYLQLGNNHLEGNIPISLGRLSNLKILVLSRNNLSGIIPPSFYNLSAMKEIRMSTNKLHGGLEPELGFAFPELEILHLGGNHLSGRIPVAVTNISSLKQFDIHSNGFSGLVPGDMGKFQNLELFSINYNELGNGEEGDLDFLSSLTNCSRLKLLAIHMNKLSGVLPDSMANLSTQLETLYIGGNQISGNIPEGIGNLVKLAQIHVGENLLTGEVPTSIGKLRNVGRFDLSLNRLSGEIPSCIGNLSLLSHLYLNGNSFEGRIPLTLEKCKSMQIMDLSTNKLSGGIPDQLVAGFERLVTLNLSHNSFNGSFPSGVSNSKNLVELYADNNNFSGEIPERFGEISELRILHMQGNYFHGSIPQSLASLRGLESLDLSSNNLSGTVPLELRNLPFLVSLNLSFNLLEGEVPEEGVFKNISQFSIAGNKDLCGGIPEIELPKCLNQAEKGKRNGLSTKSIIVIVISLSLALASVAFISILCWRKRFGKKMIPLTLEPVNLMQVSYRELVQATNGFATSNIIGEGSFGSVYKGFLDQQENPVAIKVLNLQNLGAVKSFAVECKALRNVRHRNLVKLITCCSSIDYQGNDFKAIVLEFMANGSLESWLHHEHDQDHSSHHLNFAQMLDIAIDVANALDYLHHRCQTPIVHRDLKPTNVLLGDDMVAHVGDFGMAKFLFDVASNLDNEQAISSIIKGTIGYLAPEYGMGGSTSPEGDIYSYGILVLEMITRKRPTDDMFDDEMSLHSYCKMSLPEKLEEIFDFRLLEQIKEKSQKIIGDQNIDCNMLDCLVSFTNVGVACSVEVPVERMKIEDVVNELHAIKARLHARNRIDPQQEIKELEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYV0</accession>
    <name>A0A0D2UYV0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G279300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYV0"/>
    <dbReference type="Gramene" id="KJB74204">
        <property type="protein sequence ID" value="KJB74204"/>
        <property type="gene ID" value="B456_011G279300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74206">
        <property type="protein sequence ID" value="KJB74206"/>
        <property type="gene ID" value="B456_011G279300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778148"/>
    <dbReference type="eggNOG" id="ENOG502QQUA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1900337at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005519">
        <property type="entry name" value="Acid_phosphat_B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284:SF22">
        <property type="entry name" value="ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31284">
        <property type="entry name" value="ACID PHOSPHATASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03767">
        <property type="entry name" value="Acid_phosphat_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB74204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33096" checksum="549667EA4FB812B3" modified="2015-04-29" version="1">MSAYGHQMEREFSAQSLLSRGDTGTEMGSRYVSESGFYMTSFAATIFIAGLVTIGVVLVTSVVSLAVMLQSCENKSKGVVATIDKANDNHHYCEILALHGELNGLKPDNVPPLCRNLAVQYIETGGYTRDLDFVMRMIENFFDTVSPSKNRTDAVLIDIDNILVSDPSVRRILESYTKLHSRGWLLILLSRKHEKQRHVTTKHLNSLGFSGWSSLIMRSDLEMEMETREYFCRRRTEMKEQGNEIMSVISSQMDALMGLSLGIQLFKLPNPLYYNFENNYESRIHGLVQIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UZ10</accession>
    <name>A0A0D2UZ10_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein EARLY FLOWERING 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G287700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EARLY FLOWERING 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UZ10"/>
    <dbReference type="STRING" id="29730.A0A0D2UZ10"/>
    <dbReference type="Gramene" id="KJB74321">
        <property type="protein sequence ID" value="KJB74321"/>
        <property type="gene ID" value="B456_011G287700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775026"/>
    <dbReference type="eggNOG" id="ENOG502S43Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWETAER"/>
    <dbReference type="OrthoDB" id="1895690at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009649">
        <property type="term" value="P:entrainment of circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042753">
        <property type="term" value="P:positive regulation of circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048511">
        <property type="term" value="P:rhythmic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EARLY_FLOWERING_4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33469:SF5">
        <property type="entry name" value="PROTEIN EARLY FLOWERING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33469">
        <property type="entry name" value="PROTEIN ELF4-LIKE 4"/>
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    </dbReference>
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        <property type="entry name" value="Elf4"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein EARLY FLOWERING 4" evidence="6">
        <location>
            <begin position="27"/>
            <end position="104"/>
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    </feature>
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        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB74321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="12372" checksum="B1EA39ED1696E864" modified="2015-04-29" version="1">MANNPRNNANKKLKHHRNQDSDDFDGNPEAWATLDKNFKQVQSVLDRNRMLIQQVNDNHQSKNPDNMVKNVALIQELNGNISRVVSLYSDMSSNFSTSFHNNGHHKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V366</accession>
    <name>A0A0D2V366_GOSRA</name>
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        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G084500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_012G084500"/>
    </dbReference>
    <dbReference type="OMA" id="SEGHRRC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RNase_H-like_EbsB-rel"/>
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        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074">
        <property type="entry name" value="BNAC02G40300D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074:SF61">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB76366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="23457" checksum="8789C5F92C72F514" modified="2015-04-29" version="1">MTYLFSTISREQMRQVAYAIWAIWSARNKALHEGIKQPPESSLTKINFNVTFQSHTKKSCSGIMGRNSNGFVLGSRIIINHIPLRRRLHVFMCEVEIEGDALAIVKKINANVEDGSIISAFIKDLKALSEGHRRCHFIHIANEKNGLAHLLAIEGIKKRETTYLWRRKNDRPIRRTNFDRRKAVIVPDLVYMGRDDGSSKGLLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3H5</accession>
    <name>A0A0D2V3H5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G079100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB76234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_012G079100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB76234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="149" mass="16989" checksum="2D048ABEBCD13752" modified="2015-04-29" version="1">MENLFRSALFFPFSKFCPHSSAIKLSTQFLPSNSLAIFQIFSFIFSHRSVTFSPSVPIFQVMAVFPYLIFPSFNVSPLYFLIMFFFFFLIDCLLNEHFYSLSSPPNADLLFKKINFTPLNFSPKKCSDSASPTTTPFLPSTLVEGKTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4L4</accession>
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        <recommendedName>
            <fullName evidence="5">ZCF37</fullName>
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    </protein>
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB63945"/>
        <property type="gene ID" value="B456_010G025900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZXM">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="KHATPNI"/>
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        <location>
            <begin position="141"/>
            <end position="159"/>
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            <begin position="165"/>
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        </location>
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            <begin position="12"/>
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            <begin position="201"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="225" mass="26223" checksum="0EDF09EA3D8B42B3" modified="2015-04-29" version="1">MFHPLICGASNRQEDADYDHKSHNKDNNKNPYSGRGLDKFSALLSELEDKKQKIHLQTGSRDISMVRFMYKDSTDFVPVVVKLKDKEPKPKPVETKQQEQEAWDHKHSMETLSEAKDVMKKISRLQPDKKKNKKGFSWKRPYFYLPTFFVLVLVLLVFFGRSVSILLTCVGWYMVPTIQGGNYSNVRRGIMKKKKKKDHVRKLSNESEVVRSKSSSPVRDYHKKS</sequence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Harker D."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0601968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_013G018200"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="B3_DNA-bd"/>
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    <dbReference type="InterPro" id="IPR044800">
        <property type="entry name" value="LEC2-like"/>
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        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR ABI3"/>
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    <dbReference type="Pfam" id="PF02362">
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="3"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB78771.1"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="117" mass="13758" checksum="23AADB74744E23D1" modified="2015-04-29" version="1">MKQLFSKVLSPTDIEHRLAVPSEILWAFEFDQARRCADFEVKDKHGQTWEFRCSTRKKDFHPKPVVSKGWRKFVKDKGLQAGDKVVFYKDVEGDSSYKIITMKKVFKLFGEEVWLPS</sequence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VEL2</accession>
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            <fullName evidence="3">small monomeric GTPase</fullName>
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    <gene>
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        <lineage>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="13">Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi.</text>
    </comment>
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        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
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        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the small GTPase superfamily. SAR1 family.</text>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
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    </dbReference>
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    <keyword evidence="7 18" id="KW-0931">ER-Golgi transport</keyword>
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    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 18" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="27"/>
            <end position="34"/>
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        <ligand>
            <name>GTP</name>
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    </feature>
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        <location>
            <position position="29"/>
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        <ligand>
            <name>Mg(2+)</name>
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            <position position="30"/>
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        <ligand>
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            <position position="34"/>
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        <location>
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            <dbReference type="ARBA" id="ARBA00057753"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="193" mass="22009" checksum="06A410D0CD092C92" modified="2015-04-29" version="1">MFFLDWIYGILASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQPTQHPTSEELSIGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVFLVDSYDKERFAESKRELDALLSDEALASVPFLILGNKIDIPYAASEDELRYHLGLTNFTTGKGKVNLGDSSVRPLEVFMCSIVRKMGYGDGFRWLSQYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VEN6</accession>
    <name>A0A0D2VEN6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G242300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB68385"/>
        <property type="gene ID" value="B456_010G242300"/>
    </dbReference>
    <dbReference type="OMA" id="MDEYAMK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254179" evidence="1">
        <location>
            <begin position="23"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="82" mass="9486" checksum="54F78D2545D4073F" modified="2015-04-29" version="1">MTTFRFYTCLVLVLHAVSLSETRLLNQYIEGNKQTRYFRALFIGDTSGKAYEFNVPVMDEYAMKNPDESKRRSPGGPDPKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH61</accession>
    <name>A0A0D2VH61_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cotton fiber expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CFE5D</name>
        <name evidence="5" type="ORF">B456_011G022100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4" key="2">
        <citation type="journal article" date="2016" name="Plant Cell Rep." volume="35" first="867" last="881">
            <title>Functional divergence of GhCFE5 homoeologs revealed in cotton fiber and Arabidopsis root cell development.</title>
            <authorList>
                <person name="Lv F."/>
                <person name="Li P."/>
                <person name="Zhang R."/>
                <person name="Li N."/>
                <person name="Guo W."/>
            </authorList>
            <dbReference type="PubMed" id="26759310"/>
            <dbReference type="DOI" id="10.1007/s00299-015-1928-0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <dbReference type="EMBL" id="KR997840">
        <property type="protein sequence ID" value="ALZ50281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH61"/>
    <dbReference type="STRING" id="29730.A0A0D2VH61"/>
    <dbReference type="GeneID" id="105777902"/>
    <dbReference type="Gramene" id="KJB69399">
        <property type="protein sequence ID" value="KJB69399"/>
        <property type="gene ID" value="B456_011G022100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69400">
        <property type="protein sequence ID" value="KJB69400"/>
        <property type="gene ID" value="B456_011G022100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777902"/>
    <dbReference type="eggNOG" id="ENOG502QU3V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTWRTIT"/>
    <dbReference type="OrthoDB" id="1933168at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025520">
        <property type="entry name" value="DUF4408"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008480">
        <property type="entry name" value="DUF761_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33098:SF117">
        <property type="entry name" value="COTTON FIBER (DUF761)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14364">
        <property type="entry name" value="DUF4408"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05553">
        <property type="entry name" value="DUF761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4408" evidence="3">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ALZ50281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB69400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="37622" checksum="4C35D425366D198B" modified="2015-04-29" version="1">MASASTWMLSMKVLFISSGVLSIALGLKLSVPLVLEFSVSQAPLLWSTFRSWLKPPYLYFVINGIIITIAVSSRFHQNNGENEKTEELMQQQPRSKILVEQRPDLEYEMKSSLDFDSVETVVYEQKEIVQEVETTVFEAETNVAVVDDGDGGDVFAISKSEWIPPRRMDSSEIPLDVLFPVEKPPASSRFGHRKPVKANPEGGRALKVAKPKRHETLESTWKMITEGRAMPLTRHLKKLDTFENHGREINVETMADSPLVKKSETFRDRTNYQLPPSSSPASGKLRKEPSLSQDELNRRVEAFIKKFNEEMRLQRQESLNQYMEMVNRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHZ9</accession>
    <name>A0A0D2VHZ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zeta-carotene desaturase</fullName>
            <ecNumber evidence="7">1.3.5.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">9,9'-di-cis-zeta-carotene desaturase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G201600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol</text>
            <dbReference type="Rhea" id="RHEA:30955"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:48716"/>
            <dbReference type="ChEBI" id="CHEBI:62466"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carotenoid biosynthesis; lycopene biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chloroplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chromoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the zeta carotene desaturase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.6" evidence="7"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHZ9"/>
    <dbReference type="STRING" id="29730.A0A0D2VHZ9"/>
    <dbReference type="Gramene" id="KJB82544">
        <property type="protein sequence ID" value="KJB82544"/>
        <property type="gene ID" value="B456_013G201600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782169"/>
    <dbReference type="eggNOG" id="KOG0029">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHANCRD"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="UniPathway" id="UPA00803"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009509">
        <property type="term" value="C:chromoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016719">
        <property type="term" value="F:9,9'-di-cis-zeta-carotene desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016120">
        <property type="term" value="P:carotene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000111">
        <property type="entry name" value="Zeta-carotene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014103">
        <property type="entry name" value="Zeta_caro_desat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02732">
        <property type="entry name" value="zeta_caro_desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF41">
        <property type="entry name" value="ZETA-CAROTENE DESATURASE, CHLOROPLASTIC_CHROMOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5 7" id="KW-0957">Chromoplast</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="8">
        <location>
            <begin position="67"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB82544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="566" mass="62429" checksum="02EBB5B72E5F06EE" modified="2015-04-29" version="1">MASASFLFAATGLSSVGGVKSPRLFVKSSLDNNVSDMSVNAPKGLFPPEPEHYRGPKLKVAIIGAGLAGMSTAVELLDQGHEVDIYESRSFIGGKVGSFVDRRGNHIEMGLHVFFGCYNNLFRLMKKVGADKNLLVKDHTHTFVNKGGELGELDFRFPVGAPIHGMRAFLSTNQLKTYDKARNALALALSPVVKALINPDGAMRDIRDLDNISFSDWFLSKGGTRMSIQRMWDPVAYALGFIDCDNISARCMLTIFSLFATKTEASLLRMLKGSPDVYLSGPIRNYITERGGRFHLRWGCREILYDKSADGETYVTGLAMSKATNKKLVTADAYVAACDVPGIKRLLPSGWRESEFFNNIYELVGVPVVTVQLRYNGWVTELRDLQRARQLRQAIGLDNLLYTPDADFSCFADLALTSPEDYYIEGQGSLLQCVLTPGDPYMPLPNDEIIKRVSKQVLTLFPSSQGLEVIWSSVVKIGQSLYREGPGKDPFRPDQKTPIKNFFLAGSYTKQDYIDSMEGATLSGRQASAYICDAGEELAALRKKLAMVGSQEQMETSSVTDELSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VRD0</accession>
    <name>A0A0D2VRD0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G243400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VRD0"/>
    <dbReference type="Gramene" id="KJB73685">
        <property type="protein sequence ID" value="KJB73685"/>
        <property type="gene ID" value="B456_011G243400"/>
    </dbReference>
    <dbReference type="OMA" id="DIYQSSD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="41258" checksum="66E70E6C66B030EE" modified="2015-04-29" version="1">MNRLSQGLPLMGAHQGNQVEDYREGQTSHDNSNKSQQQHRPPREGYQSSVDLQQQHRPPLETYKSSDHIQQQHPPPRDIYQSSDHLQQQHRPPRETYKSSDHIQQQHQPPRESYQSSDHLHQQQRQPPRESYQSSDHLHQQQSQPPPESYQSSDHFQQQQYHPRESYQDSEHLQQQHRPPRESYQCSNHLQQQLQPSESYHQSFNHLQQHQHQPRESYQSSDHLPPRESYQNADHLQQQQAPVIKGYATKDDSSSLINKVASDHQLPSVIDPSKHVHRPSGYQTSHSPTPRLKPPSTHDPNSILMNPKPRSLLYHEEYAMTHGNTADDSAEAENKNVKVKRTHTNKPQSSSCCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VU76</accession>
    <name>A0A0D2VU76_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G013700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VU76"/>
    <dbReference type="STRING" id="29730.A0A0D2VU76"/>
    <dbReference type="Gramene" id="KJB74905">
        <property type="protein sequence ID" value="KJB74905"/>
        <property type="gene ID" value="B456_012G013700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFPEVVF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="63"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB74905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="340" mass="38373" checksum="EFCF82C412BE19EC" modified="2015-04-29" version="1">MGQLPPHLELQRSRVSCNKDAPIHTESIQYSGAYASMGIDNSSRLDRFSNNFRVEVVRLNEDDMEFDMIGIDAAIANSFRRILIAELPKMAIEKVLIANNTSIIQDEVLAHRLGLVPIQNDQPNEKNTIVFKLHVQCKRGSPRITVKSDALKWLPNGSELVKETRNATSDSSSKPETYTYFCCSQETIPEFVKNPIIPKYPDIIIAKLGPGQEIELEAYAVKGIRKTHAKWSPVATAWYRMLPEVVLLEDIEDDLAEELKSKCPVNLFDIEDLGKGRRATVARPRACTLCRECIRGDDWEKRVALHRVKDHFIFTIESTGALPPEVLFTEAVKILEDTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYT4</accession>
    <name>A0A0D2VYT4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G128300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYT4"/>
    <dbReference type="STRING" id="29730.A0A0D2VYT4"/>
    <dbReference type="Gramene" id="KJB77260">
        <property type="protein sequence ID" value="KJB77260"/>
        <property type="gene ID" value="B456_012G128300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780693"/>
    <dbReference type="eggNOG" id="ENOG502S0G4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TKRQTMV"/>
    <dbReference type="OrthoDB" id="1723663at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35103">
        <property type="entry name" value="OS06G0115700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35103:SF1">
        <property type="entry name" value="OS06G0115700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="297" mass="33300" checksum="4EDAF0CFFBC80208" modified="2015-04-29" version="1">MMALNLGANLQTIAFPLNSPATLTLNSPLKLQIQKPTTPLTHTIRTPLSSISLNCLSKFPKGSQTTTKRQTMVVSLGPGKFYGSSLPRPRIYTDTKFNPERVDPPVPVLDPLLSWADEAHWSMGGLSFKRLRLQGRIEGNVKRLKAQRKKLLKDTPDRGLNLKKSLRDDEDDEDVSPPPAPVAVKRRRFLDLNDDDDTESENKGDDDEEVTVAKRKKKRVLRNGAVRKLGDDFERVAKNSGLVSKRGRNFSDGIGSDVKKMVEEVNDEPESEEDKKKTEAQSGRSRTSPRLARRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W164</accession>
    <name>A0A0D2W164_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G261700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W164"/>
    <dbReference type="Gramene" id="KJB78420">
        <property type="protein sequence ID" value="KJB78420"/>
        <property type="gene ID" value="B456_013G261700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB78420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="12156" checksum="D51147F06AB90CF2" modified="2015-04-29" version="1">MKKSEKSTLRASQLQDFCRRKNNAELIENNRILYLKLQAKEIVDTNFGYGGRRQLTERWSINGIVMKVTWFWWEGVELLSLFYRGPSLYHERATCHNVTESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W2I5</accession>
    <name>A0A0D2W2I5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">diaminopimelate decarboxylase</fullName>
            <ecNumber evidence="11">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_013G035500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>meso-2,6-diaminopimelate + H(+) = L-lysine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W2I5"/>
    <dbReference type="STRING" id="29730.A0A0D2W2I5"/>
    <dbReference type="Gramene" id="KJB79155">
        <property type="protein sequence ID" value="KJB79155"/>
        <property type="gene ID" value="B456_013G035500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783403"/>
    <dbReference type="eggNOG" id="KOG0622">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HGNAKSP"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000003">
        <property type="entry name" value="Diaminopimelate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000003">
        <property type="entry name" value="Diaminopimelate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727">
        <property type="entry name" value="DIAMINOPIMELATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF2">
        <property type="entry name" value="GROUP IV DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="14">
        <location>
            <begin position="98"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="15">
        <location>
            <begin position="104"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00050464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB79155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="488" mass="54088" checksum="248BCF8E91BCFC31" modified="2015-04-29" version="1">MAATTHHHLSHASSLPKTLNHPLKQNPFSQLPVLSLRASKNLFRRQSLSLRAVLSQNPAKTLNATFQHCFTKSPDGFLYCEDTKVQDIMEKVEKRPFYLYSKPQITRNVEAYKEALEGLKNSIIGYAIKANNNLKILQHLRKLGCGAVLVSGNELKLALHAGFDPTKCIFNGNGKILEDLILAAQEGVFVNVDSEFDLENIVTAAKVAGRKVNVLLRINPDVDPQVHPYVATGNKNSKFGIRNEKLQWFLDAVKAHPNELKLVGAHCHLGSTITKVDIFRDAAVLMVNYIDEIRAQGFEVDYLNIGGGLGIDYYHSGAVLPTPRDLIDTVRELVLSRNLNLVIEPGRSLIANTCCLVNRVTGVKTNGTKNFIVIDGSMAELIRPSLYDAYQHIELVSPTPPDAEVSTFDVVGPVCESADFLGKERELPTPAKGTGLVVHDAGAYCMSMASTYNLKMRPPEYWVEEDGSVTRIRHGETFEDHIRFFEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W3G9</accession>
    <name>A0A0D2W3G9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6817 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G066900</name>
        <name evidence="3" type="ORF">Gorai_002460</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0602274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W3G9"/>
    <dbReference type="Gramene" id="KJB79790">
        <property type="protein sequence ID" value="KJB79790"/>
        <property type="gene ID" value="B456_013G066900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781842"/>
    <dbReference type="eggNOG" id="ENOG502QT11">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWGRVML"/>
    <dbReference type="OrthoDB" id="2306007at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049202">
        <property type="entry name" value="DUF6817"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37391">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37391:SF4">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20680">
        <property type="entry name" value="DUF6817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6817" evidence="1">
        <location>
            <begin position="38"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0602274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="417" mass="47098" checksum="D63AC68DECB662DD" modified="2015-04-29" version="1">MASSSPSQYLESLLDTVRPFLRGDLESVDGNLPSFLAVLRSAGAGECSHQHGSFLQHLLDVYRILKIWKAPRSVCLCGLFHGAYSNAYVNLAIFDASTSRDVVRGHVGEVVERLIHLFRVIPRQKFIHDDLLFKYTDSELVEHLKASEISLKNAKEKGLFDKDELWRKKLEALVPKNGIVMKIIKSGEEVLVAREVMCVFLLMSMADYSEQFFGYHDQLFDNFDGKFRFLGDNYDALLPGDGKPGLWMSSISKMGATYTLILRDEAIILEEKKRVNGENIEEVIDEGLDLVVPPVFDNCTKVLGAKEQVEARDLYWEAICGGGGRAEELLLGCCERNPFVGEPHVVLAQVYLNQGRFEEAEKEAERGVTLMLEWGSPWDNRMSWEGWVAWGRVLLLRAKEKSWPHSAWGVLSLGLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W728</accession>
    <name>A0A0D2W728_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G175700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2W728"/>
    <dbReference type="STRING" id="29730.A0A0D2W728"/>
    <dbReference type="Gramene" id="KJB82085">
        <property type="protein sequence ID" value="KJB82085"/>
        <property type="gene ID" value="B456_013G175700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782819"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="305"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="690"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="12">
        <location>
            <begin position="709"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="123"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB82085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="892" mass="101038" checksum="CE26798C5B647D15" modified="2015-04-29" version="1">MAVDSSDRKEFILKIDDRSHDGSISTPSGGATAGDGGKIWGEPSYDFWKDGEKININWKKENANSNDAGSSGGVSNKESEDFEFMQSEQVPMDDPPSKLIGQFLHKQKASGEISLDMDLEMDELQQKQTHDGILLPTVAETPSPSAAALSRVSFENSPVRRRQSKGPASTGKEETDGVVKCSSNSSFKRSEGGSTQRKSSLLANKTKSRLMDPPTSERGEPKSGKTGVGKSGQVMRSGILGKSMEEEEDDSLLDEDLPDEYKIDKLSFLVLLQWLSLILIIAALVCSLTIPYLRKKRLWDLMLWTWEVLVLVLICGRLVSGWIIRIIVFFIERNFLLRKRVLYFVYGVRKAVQNCLWLGLVLIAWHYLFGKKVQRETKSDVLRFVTKIMICLVVGVMLWLVKTLLVKVLASSFHVSTYFDRIQESLFNQYVIETLSGPPLVEIRRAEEEEERLANEVANLQKAGAKIPPGLKTSTLSSPQYKRPIGSGPIQKSPRAKSPMISRVLSVEKGEKDDKGITIEHLHKLNPKNVSAWNMKRLMNIIRHGALSTLDEQIQDSTQEDESATQIRSEYEAKVAARKIFQNVAKPGSKYIYLEDIERFLPEDEALKTMSLFEGASESRRISKKALKNWVVNAFRERRALAFTLNDTKTAVNRLHRMVDILVGIIIVVIWLLILEIASSKVLVFISSQLLLVAFVFGNTCKTVFEAIIFLFVMHPFDVGDRCEIDGVQMVVEEMNILTTVFLRYDNQKVIIPNSVLATKAIHNYHRSPDMGDAVEFCIHVKTPAEKIGLMKQRIMSYIEHKSDHWYPDPMIIFKELEELNRVRIAIWLTHRMNHQDMGERFTRRALLIEEMVKIFNDLDIEYRLYPININVCSVPPTASDRLPPKWTGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W8R9</accession>
    <name>A0A0D2W8R9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Potassium channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_013G232800</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Potassium channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The KHA domain (rich in hydrophobic and acidic residues) present in the C-terminal part is likely to be important for tetramerization.</text>
    </comment>
    <comment type="domain">
        <text evidence="16">The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids. The pore-forming region H5 is enclosed by the transmembrane segments S5 and S6 in the Shaker-type (1P/6TM) and contains the GYGD signature motif which seems to be involved in potassium selectivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the potassium channel family. Plant (TC 1.A.1.4) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W8R9"/>
    <dbReference type="STRING" id="29730.A0A0D2W8R9"/>
    <dbReference type="Gramene" id="KJB83170">
        <property type="protein sequence ID" value="KJB83170"/>
        <property type="gene ID" value="B456_013G232800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783145"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KRVTFQN"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000074">
        <property type="entry name" value="Potassium channel KAT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000139">
        <property type="entry name" value="Potassium channel SKOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003938">
        <property type="entry name" value="K_chnl_volt-dep_EAG/ELK/ERG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045319">
        <property type="entry name" value="KAT/AKT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021789">
        <property type="entry name" value="KHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45743:SF2">
        <property type="entry name" value="POTASSIUM CHANNEL AKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11834">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01463">
        <property type="entry name" value="EAGCHANLFMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51490">
        <property type="entry name" value="KHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="14 16" id="KW-0407">Ion channel</keyword>
    <keyword evidence="12 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 16" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="4 16" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="17">
        <location>
            <begin position="373"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="551"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="584"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="15">
        <location>
            <begin position="648"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="KHA" evidence="18">
        <location>
            <begin position="794"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="875" mass="98829" checksum="3CDD62DC27231E5B" modified="2015-04-29" version="1">MFRVSVCGQEDIEQISRESSHYSLSTGILPSLGARSNRRVKLKRFIVSPYDRRYRVWETFLVILVIYTAWVSPLEFGFLKKPESPLSITDNVVNGFFAMDIILTFFVAYLDKTTYLLIDDHKKIAWKYSSSWLAFDIISTIPSELAQKISPKPLRSYGLFNMLRLWRLRRVSALFSRMEKDKNYNYFWVRCAKLICVTLFAVHCAGCFYYYIAARYHDPGRTWIALSLGDNFLEQSLWIRYVTSMYWSITTLTTVGYGDLHPVNTREMVFTIFYMLFNLGLTAYLIGNMTNLVVHGTSRTRRFRDTIQAASSFALRNQLPHRLQDQMLAHLCLKFRTDSEGLQQQEIIDSLPKAIRSSISHYLFYSLMDKVYLFRGVSNDLLFQLVSEMKAEYFPPKEDVILQNEAPTDFYILVTGAVDLLVLKNGAEQVVGEAKAGDLCGEIGVLCYRPQLFTVRTKRLCQLLRLNRTAFLNIIQANVGDGTIIMNNLLQHLKDMNDPIMEGVLIETENMLARGRMDLPLNLCFAALRGDDLLLNQLLKRGLDPNESDNNGRTALHIAASKGSENCILLLLDYGADPNVKDSEGNVPLWEAMLAGHDQVAKLLKENGASINVGDVGHYACTAAEQNNLNLLKEIIRYGGDVTRPRHNGTTALHVAVCEGNVEIVKYLVDQGADIDKPDVHGWTPRELAEQQGHEEIKTMFESRREMKTQSIMSIPEKAETRYLGRFTSEPVIRPVAPDGTDGSWSQSRQRRRTSNFHNSLFGIMSAANNMEKDLLLSVHKPKGVKDCVVNSARVVISCPEKGQTIGKLVSLPGNFEELLEMGAKKFGIIGGKVVSKEGAEIDGIEVIRDGDHLVFVSDGQMVHQQHSQVPHCIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LY06</accession>
    <name>A0A0D2LY06_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G126900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LY06"/>
    <dbReference type="STRING" id="29730.A0A0D2LY06"/>
    <dbReference type="Gramene" id="KJB09157">
        <property type="protein sequence ID" value="KJB09157"/>
        <property type="gene ID" value="B456_001G126900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793154"/>
    <dbReference type="eggNOG" id="KOG1520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFITQMG"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.30:FF:000060">
        <property type="entry name" value="Putative strictosidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF106">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002258255" description="Strictosidine synthase conserved region domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="6">
        <location>
            <begin position="180"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB09157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="391" mass="43747" checksum="F79E1C0B23780867" modified="2015-04-29" version="1">MTPVGILGILFLLLALYCGTDPFKHSAISEFPDFEAYKVDMPPWEMVPMVRDKDNLLQKSEIKFLNQVQGPESMAFDPLGRGPYTGVADGRIVFWDGEKWNDFAHTSSNRSELCNPKPSPLSYLPNEHICGRPLGLRFDKKTGDLYIADAYLGLLKVGPEGGLATSLVTGANGVPLRFTNDLDIDDEGIVYFTDSSSKYQRRNFKQLIFSSENGGRLIKYNPHTKETTILMTNLQFPNGVSLSKDGTFLVCCEGCPGRLLRYWLKGEKAGTWEVFAILPGFPDNIRTNKDGEFWVAINSRRSMYAHILGLHPKVRKFILKLPISTKVQVLLHVGGKLHAQVVKYSPEGKLLRILEDSEGKVVKAVSEVDERDGKLWLGSVLMPFIAVYDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M9P6</accession>
    <name>A0A0D2M9P6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_002G116000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M9P6"/>
    <dbReference type="STRING" id="29730.A0A0D2M9P6"/>
    <dbReference type="Gramene" id="KJB14257">
        <property type="protein sequence ID" value="KJB14257"/>
        <property type="gene ID" value="B456_002G116000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1613">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <location>
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    </evidence>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB14257.1"/>
        </source>
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        <source>
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        </source>
    </evidence>
    <sequence length="303" mass="32453" checksum="5C2419CA30712CAD" modified="2015-04-29" version="1">MGLPNASGDLSTEVEVDAFRRLFPLRFYEKHLLESIRPDARPLGRARETTIALGAVASANGSALAKIGSTTMLAAIKMEVMTPSLETPDEGCIGLLPLAARFPVSLSLLKTPGRPAEAAPVVAKQLSDTILSSGMINLKELSLVSGKAAWMAYLDIYCLDADGALFDTALLSAVAAFSHLEIPVVSLNDDGKIVLSEEQGLSDREPVNKEKRKINLSSVPFSLTCVLHKNYILADPTAEEESIMDTIVTVVLDSSSQLVSLQKPGGTVLAYTSAIQDCIALTRQRVKELQKILEEAISGMEVD</sequence>
</entry>
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    <accession>A0A0D2ME11</accession>
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        <name type="scientific">Gossypium raimondii</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="89"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB16052.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="13037" checksum="4D4B6DA2EB814AA5" modified="2015-04-29" version="1">MKTLFFFFIFCSFLLYGNLNHARKEPRDYWKSVMKDQPIPEAIQGLLHQDEASAMDSENFVKDFDSRHSFIIYHSNLKHKEEEDKTYVKDLKNQKEHKSDKKNQTEKY</sequence>
</entry>
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    <accession>A0A0D2MPI5</accession>
    <name>A0A0D2MPI5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G184700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
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                <person name="Rainville L.N."/>
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                <person name="Reddy U.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_003G184700"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="probable calcium-binding protein CML18"/>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Byers R."/>
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                <person name="Doron-Faigenboim A."/>
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                <person name="Grover C."/>
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                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="68" mass="7278" checksum="8BA8254E5580CC7A" modified="2015-04-29" version="1">MATKQRSFNDATPVWRSWNECVVGDDGCCNVGCWAFVREDSCCGTKAGKETAAAALRRKGFAGFIGLG</sequence>
</entry>
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    <name>A0A0D2N3T6_GOSRA</name>
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            <fullName evidence="19">Cellulose synthase-like protein D3</fullName>
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    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
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                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <source>
            <strain evidence="16">8</strain>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="16">8</strain>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 2 family. Plant cellulose synthase-like D subfamily.</text>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N7L9</accession>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <source>
            <dbReference type="EMBL" id="KJB08663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="36" mass="4238" checksum="FD1120A5C414F274" modified="2015-04-29" version="1" fragment="single">MNHQSKETFRCFGCKRKVKGPSLSCSDCEFFLYKEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGJ8</accession>
    <name>A0A0D2NGJ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone deacetylase</fullName>
            <ecNumber evidence="3 12">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_005G215000</name>
        <name evidence="19" type="ORF">Gorai_017244</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 12"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGJ8"/>
    <dbReference type="STRING" id="29730.A0A0D2NGJ8"/>
    <dbReference type="Gramene" id="KJB31937">
        <property type="protein sequence ID" value="KJB31937"/>
        <property type="gene ID" value="B456_005G215000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB31939">
        <property type="protein sequence ID" value="KJB31939"/>
        <property type="gene ID" value="B456_005G215000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795013"/>
    <dbReference type="eggNOG" id="KOG1342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF44">
        <property type="entry name" value="HISTONE DEACETYLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="17">
        <location>
            <begin position="36"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="384"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="457"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0586505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="485" mass="54918" checksum="625AC180F5AEE683" modified="2015-04-29" version="1">METGGNSLPSGPDGVKRKVLYFYDPEVGNYYYGQGHPMKPHRIRMTHALLAHYGLLQHMQVHKPVPARDRDLCRFHADDYVNFLHNVTPETQQDQLRQLKRFNVGEDCPVFDGLFSFCQTYAGGSIGGAVKLNHGFCDIAINWAGGLHHAKKCEASGFCYVNDIVLAILELLKQHQRVLYVDIDIHHGDGVEEAFYTTDRVMTVSFHKFGDYFPGTGDIRDIGYSKGKYYSLNVPLDDGIDDESYHYLFKPIISKVMEVFRPGAVVLQCGADSLSGDRLGCFNLSIKGHAECVKFMRSFNVPLLLLGGGGYTIRNVARCWCYETGVALGVEVDDKMPQHEYYEYFGPDYNLHVSPSNMENKNSRQLLLEIRNKLLDNLSKLEHAPSVQFQEREPDTELPEADEDQDDGDERWNSDSDMDIDEDRKLIIPSRVKREVIEPETRDPVCSMEVQIETIEQTRGFDTATNETGVDVSPMPIDVPTVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGZ2</accession>
    <name>A0A0D2NGZ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G221600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGZ2"/>
    <dbReference type="Gramene" id="KJB32077">
        <property type="protein sequence ID" value="KJB32077"/>
        <property type="gene ID" value="B456_005G221600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795085"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHDENMK"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001533">
        <property type="entry name" value="ABC transporter G family member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF1">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="35"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB32077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="652" mass="71991" checksum="8577AC9A27D098E3" modified="2015-04-29" version="1">MQGGPEICKAENLNPMPGSNTGSRSNIFMEDGVFLTWDDLWVTVAGGRPILQGLAGYAHPGELLAVMGPSGCGKSTLLDTLAGRRSPKTRQEGDILFNGRKQALAYGTSAYVTQDDALITTLTVREAVYSSAQLQLPDTMAKSEKKERAEKTIREMGLQDAMDTRIGGWGAKGLSGGQKRRVSICIEILTHPMLLFLDEPTSGLDSAASYYVMSRIASLNQKDNIGITIIASMHQPSAEVFQLFTNLYLLSSGKTVYFGPVSAANEFFALNGFPCPSFQNPSDHFLKTINKDFGKDIELGFANGIPTEEVIDILVKSYKSSDIYQMVQKEIAQICKQGGGALQKSKRRSGLFTQCHVLTRRSFINMSRDLGYYWLRLGIYISLAIVLGSVFSHIGLDNGSIQARGSLLMFVATFLTFMAIGGFPSFVEEMKVFERERLNGHYGVTPFVIGNTLSSLPFLAMVALIPGAITYFLPGLHHGYQHFLFFVIILFACMMLVESLMMIVASVVPNFLMGIIVGAGIQGLMILVGGFFRLPSDLPKPVFKFPLYYIAFHKYAYQGLFKNEFVGLTFPNVQAGNGSSPTITGEDILKRTWRFEMAYSKWVDLAILFAMIVLYRVLFLIINKTTEKEKAVIGKFMSATWKDKAPVSRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJV5</accession>
    <name>A0A0D2NJV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G081900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJV5"/>
    <dbReference type="Gramene" id="KJB13568">
        <property type="protein sequence ID" value="KJB13568"/>
        <property type="gene ID" value="B456_002G081900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780171"/>
    <dbReference type="eggNOG" id="ENOG502RXRB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RENTNWI"/>
    <dbReference type="OrthoDB" id="515493at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11446">
        <property type="entry name" value="bHLH_AtILR3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000104">
        <property type="entry name" value="Transcription factor bHLH34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1000">
        <property type="entry name" value="arf6 gtpase in complex with a specific effector, jip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044818">
        <property type="entry name" value="ILR3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46133:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR ILR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="123"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB13568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="238" mass="26215" checksum="701EE50A80146C86" modified="2015-04-29" version="1">MVSPENSNYWSHFDYATLIDDIPVPDDPYAGFAWSTQPIDAPSNVVSVEIDGSFGDSDGLKESGSKKRVRSESCNASSSKACREKLRRDRLNDKFMELGSILEPGRPPKTDKSAILIDAVRMVTQLRGEAQKLKDSNTSLQERIKELKSEKNELRDEKQRLKAEKERLEQQLKAMNAQPSFMPPAPPAIPAAFAAAPGQAPGNKLVPLIGYPGVAMWQFMPPAAVDTSQDHVLRPPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJW3</accession>
    <name>A0A0D2NJW3_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G008200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_006G008200"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="entry name" value="WRKY_plant"/>
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    <dbReference type="PANTHER" id="PTHR31221:SF361">
        <property type="entry name" value="WRKY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
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            <end position="228"/>
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            <begin position="81"/>
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    </feature>
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            <begin position="107"/>
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    </feature>
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            <begin position="127"/>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="301" mass="34097" checksum="2BC08076B340ECCE" modified="2015-04-29" version="1">MSSSNEKNDPLYNYDPFQGFNSSTFPFFDYNNLLVYSQAAPTPPFQGLDSSYMNFTDCLHDQNSFSRPFFDLSGSSSDVVGPVHDNISNSKQTVDDSVRINIDNTENPSTPNSSVSSPSNGGTAVEDSSKTNKGSEHEKSKKVNKPKKERQQREPRFAFLTKTEIDVLEDGYRWRKYGQKAVKNSPYPRSYYRCTAQKCGVKKRVERSFQDPSVVITTYEGRHNHQIPISLRGNNITSSAGFPHEFLAHYFFPSTSNHQEENSIQHQSVALHQHQQQQQLQVSDYGLLHNLVSPSTRKQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKR8</accession>
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            <fullName evidence="12">Transmembrane protein 245</fullName>
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        <name evidence="9" type="ORF">Gorai_022637</name>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
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    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
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    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_002G102500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782193"/>
    <dbReference type="eggNOG" id="KOG2365">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR002549">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716:SF72">
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        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01594">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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    <feature type="transmembrane region" description="Helical" evidence="7">
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        </location>
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        <location>
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        </location>
    </feature>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0580418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="72465" checksum="1E801F0606530370" modified="2015-04-29" version="1">MELVPYSSEPKPKPSSSTLPWQDMFRSASVRKPSPAPGNSDAPPNQHHAPPQTPNSTDPDHKNSLSGDPQVRLALYIAMAHAGLAFTIFILYAICKLLQEYFRPIQWAILCSIPLRGIQETLVGFWSEPLRLGLTETVLAVPVAVFKAFIGTLVDIKDVCLRVFLKRPKSNLSRRKRSGFPMLVRWLVAFAVFVIAYERIGGVGSLGIIVLGFVISTKNIDDSLTAVSSFRSNSFRRSRMSAYFTTRILKRLDTIVAIGLIIGLFVGFFAGATFFSYKIGVEGKDAVVSVKSHVEESNYAERMGVKRWMEENDVPGMVDKYTTQFYETVSEQIDNLAMQYNMTEFVTGIKHFVITSTTSSSVRSTALMTPSPYTEKFLSLRKRVSNREWGQIYTEVDAIFRELIITREDLVQKAKGFAVKGADVSQRVLASSASVLGGGAKIMFTIGNSILYGAAEVFNFVSQLMVFFWVLYYLITSESGGVTEQVMSMIPISKPARIRCVEVLDEAISGVLLATAEIAFFQGCLTWLMFRLFEIHFVYMSTVLAFISPLLPIFPPWFATIPAAIELVLESRYIVAVVFSISHIVLMDYGATEIQESIPGYSAYLTGLSIIGGMTLFPSAVEGAIMGPLITTVVIALKDLYVEFVLEEPKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NM47</accession>
    <name>A0A0D2NM47_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin response factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G124400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Auxin response factors (ARFs) are transcriptional factors that bind specifically to the DNA sequence 5'-TGTCTC-3' found in the auxin-responsive promoter elements (AuxREs).</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ARF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NM47"/>
    <dbReference type="STRING" id="29730.A0A0D2NM47"/>
    <dbReference type="Gramene" id="KJB14423">
        <property type="protein sequence ID" value="KJB14423"/>
        <property type="gene ID" value="B456_002G124400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784599"/>
    <dbReference type="eggNOG" id="ENOG502QQ0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LKPNKHP"/>
    <dbReference type="OrthoDB" id="1368538at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1040:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000001">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000047">
        <property type="entry name" value="Auxin response factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010525">
        <property type="entry name" value="ARF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044835">
        <property type="entry name" value="ARF_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31384:SF10">
        <property type="entry name" value="AUXIN RESPONSE FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06507">
        <property type="entry name" value="ARF_AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="9">
        <location>
            <begin position="149"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="828"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="945" mass="104093" checksum="1A489D9AD306C2F2" modified="2015-04-29" version="1">MGSVVEEKIKQGGLVNVGAQSTLLEEMKLLKEMQDQSGTRKAINSELWHACAGPLVSLPQVGSLVYYFPQGHSEQVAVSTKRMATSQIPNYPNLPSQLMCQVHNVTLHADRDTDEIYAQMSLQPVNSEKDVFPIPDFGLKLSKHPNEFFCKTLTASDTSTHGGFSVPRRAAEKLFPSLDYSMQPPTQELVVRDLHDNTWTFRHIYRGQPKRHLLTTGWSLFVGSKRLRAGDSVLFIRDEKSQLLVGVRRANRQQTTLPSSVLSADSMHIGVLAAAAHAAANRSPFTIFYNPRACPSEFVIPLPRYRKSVYGSQVSVGMRFGMMFETEESGKRRYMGTIVGISDLDPLRWPGSKWRNLQVEWDEPGCNDKQNRVSAWEIETPESLFIFPSLTSSLKRPLYPGFSGAESEWGSLMKRPLLQFPENGNGNLPYSMSNLCSEQLMKMMLKPQLVNHPGIFASPLHQIADVKVPPLEEMKNLQSKSHTKPQVIQSENMLIENRNLSHPVPDQPDPITSNMSKINANGNPHPANILTQAGTGSSNEKLKLESKHSAEQLTSTSECNEEKLVASTVNTTMSNQLSFPTQPHIPLQVQNNPWSIQSQLDSSVLQAHQMLVSQADISTLNSFLPFSDTDEWTSNLSSCQPLSGAYKSPGPIPMVGLQDSSAVFPVETDDSLTTVGEEIWDQKLNNCRVSSQADQLASFTQQDPCSLNSGGVRDLSDDSNNQSGIYSSCLNIDVSNGCSTVIDPFVSSAILDEFCSLKDADFQNPSDCLVGNFSSCQDVQSQITSASLADSQAFSRQDLPDSSGGNIDFDDSGLLQNNSWKQTGPRVRTYTKVQKAGSVGRSIDVTSFKNYDELISAIECMFGLKGLLDDPRGSGWKLVYVDYENDVLLVGDDPWEEFVGCVRCIRILSPTEVQQMSEEGMKLLNSAATVQGINGSNSEGSNANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NMB6</accession>
    <name>A0A0D2NMB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G056900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NMB6"/>
    <dbReference type="STRING" id="29730.A0A0D2NMB6"/>
    <dbReference type="Gramene" id="KJB34272">
        <property type="protein sequence ID" value="KJB34272"/>
        <property type="gene ID" value="B456_006G056900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWLEREH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704:SF37">
        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="29352" checksum="8F7F495913EDB94F" modified="2015-04-29" version="1">MGKGFSQRQLKNRWDDLKKEWKAWKKLKGEDTGLGWNPIKRTVDASDEWWESRLQVVPEAKKFRTSGIDPEFEGKLDQMFMGIVATGDKAWAPSSGTLPSDFFEDVNNEIPEENEEENMRNDVHILNDVHISNDVQIDGNSQKRKNPEMSSSHFKTGRKKSSKQIGGAARLSSQIEKLCNATDNMSQATYSLNLVMDPYGVPQAVKMLDSMSEEVPEASPLYFFALRLLLNKDKRIMFLSISLKIRALWLKTEMEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQR0</accession>
    <name>A0A0D2NQR0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G117700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQR0"/>
    <dbReference type="Gramene" id="KJB35502">
        <property type="protein sequence ID" value="KJB35502"/>
        <property type="gene ID" value="B456_006G117700"/>
    </dbReference>
    <dbReference type="OMA" id="MGIDDTW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB35502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="72" mass="8952" checksum="61D59EC7C845FB58" modified="2015-04-29" version="1">MLGERKWECRPRWRWEKLRSIFLRRQRNKNRADTQTDKSMGIDDTWMLVRRKTTWIKIGPMDKKTNKQTRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NW70</accession>
    <name>A0A0D2NW70_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G210000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NW70"/>
    <dbReference type="STRING" id="29730.A0A0D2NW70"/>
    <dbReference type="Gramene" id="KJB37552">
        <property type="protein sequence ID" value="KJB37552"/>
        <property type="gene ID" value="B456_006G210000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800241"/>
    <dbReference type="eggNOG" id="KOG1363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAYFTHG"/>
    <dbReference type="OrthoDB" id="1920064at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14351">
        <property type="entry name" value="UBA_Ubx1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF93">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="487"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="286"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="432"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB37552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="569" mass="62792" checksum="7DAF16149BF56B22" modified="2015-04-29" version="1">MVRPNQEAIDTFISITGAPEAVAISMLEEHAGNLNTAVNAYFSEGDRPRSTIVPVDDAMDIDDPNEVVPNGPVLPFLPSSRTNEQSSLHDRNFHSSFFDGDSGSTHEPMVTHPTEVREVKNSHEPSSHAPVVEDASETAQALGPNSHETVTIDEVGDDSIAQPRWQNDNSNNQHVTPSAPAFDNLPDYGNDIEEQMIQAAIEASKRDTEELSNTVPWHNMSHSEDAVLEEAVSLSFKTAEQEKALREQGYCARTSEVEASIPPNEHLGNIAVSNGRLMEGSSSIQAEAADGDEQPLFRHRSRQTSSGPGESANEVGVVEASAPSSPGQQGIGNPPLNNGNEFPSDEWGGISSVEHDEAVMLEAAMFGGIPENGYRFAYAPHHFIRPEGSNPWRTPRPPSPSLEAQRLIREQQDDEYNASLQADREKELKAIQEAEACRLEEEAARKAALEEEKRKEEESRRKMEEEQECERQLAAKEASLPLEPSADEENAVNLLVRMPDGSRRGRLFLKSDRLQSLYDFIDIGRGVKPGTYRLVRPYPRRAFSDDECSLTLNELGLANKQEALFLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PKW1</accession>
    <name>A0A0D2PKW1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G026900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PKW1"/>
    <dbReference type="STRING" id="29730.A0A0D2PKW1"/>
    <dbReference type="Gramene" id="KJB07469">
        <property type="protein sequence ID" value="KJB07469"/>
        <property type="gene ID" value="B456_001G026900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICWTFGL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF155">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HERC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="97"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="114"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="177"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="240"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="293"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="519" mass="56273" checksum="2DE9A7A07323BCEA" modified="2015-04-29" version="1">MESAAGTADDSGNMPHKVVAVAAGEAHTLALSGDGYVYSWGRGMFGRLGTGSESDEIFPVRVKFQNSELKLIAVAAGAYHSLALADDGSVWSWGYNICAVKAGGMTSLAIDNLGALWMWGNYPQENNNGDGSLTFVSCFTPTPVWDFHGHTVVKVACGNEHVVALVSAGERHKGDDLLCYSWGGNGHGQLGLGDTESRARPEIVGTFSQDIQWTVYEVACGAFHTALLTRKKRPSDTLESMCWTFGLGDRGQLGHGTTRSALVPEPVKELPQPVYLVSVDCGLFHTSVVSSAGDVWSWGMEKGLGLCPDASFTGTDSGDAISPLRIHGPKFNDPVQVSCGAAHTVLVAHDGYKLWSWGRGRSGVLGNGKTVDCFSPTIVLWPPLNEDFKQEELNQDDKIVDQKGSDGVSEMEKKLSLAMEEMKLLQSKLSTMERYASILHGSIFGKPFEVQDIPISLQNSGTFDIAREWENMLESSDRSGLVRLELFYRNMLTGVKDKILKKRIQELIKECLPSSAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PMQ5</accession>
    <name>A0A0D2PMQ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G046500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PMQ5"/>
    <dbReference type="STRING" id="29730.A0A0D2PMQ5"/>
    <dbReference type="Gramene" id="KJB28413">
        <property type="protein sequence ID" value="KJB28413"/>
        <property type="gene ID" value="B456_005G046500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796694"/>
    <dbReference type="eggNOG" id="ENOG502QPNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMAQKNS"/>
    <dbReference type="OrthoDB" id="642974at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF260">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="130"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="14"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="248" mass="26857" checksum="40F352B9E92559EA" modified="2015-04-29" version="1">MLGTERDLNFNETELCLGLPGGSGGGGGAAAAGGGGKNEVESSPKTTGKRGYSETVDLKLNLQSKEGCMDLNQNLENGSKEKNHLPAKPPAKAQVLGWPPVRSYRKNIMANQKNNSDEISDRASSGSGGAAFVKVCMDGAPYLRKVDLKMYNSYQKLSDALAKMFSSFTMGSYGCEGMIDFMNESKLMDLLNSSDYVPTYEDKDGDWMLVGDVPWEMFVDSCKRLRIMKGSEAIGLAPRAMEKCKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PN47</accession>
    <name>A0A0D2PN47_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G055900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PN47"/>
    <dbReference type="Gramene" id="KJB28563">
        <property type="protein sequence ID" value="KJB28563"/>
        <property type="gene ID" value="B456_005G055900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000007">
        <property type="entry name" value="Phosphatase 2C and cyclic nucleotide-binding/kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="14">
        <location>
            <begin position="54"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB28563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="446" mass="49042" checksum="3FD9485FD181B933" modified="2015-04-29" version="1">MGCANGKCCSRDSSTSDEDSGHHQRGIRPYKNKDGLTQRSLELVHVPSHNFTLQYSSLTQNGYYPDTTDRENQDSFCIKTQIQGNPNVHFFGVFDGHGQYGAQCSNFVKDKLVEILSSDPTLLDDPLKAFNSAFLATNSELRDSEIDDALSGTTAITVLVVGDTLYVANVGDSRAVIAVKDGDRILAEDLSVDQTPFRKDEYDRVKLFGARVLSVDQVEGLKDPDIQHWGDEESHGGDPPRLWVPNGMYPGTAFTRSVGDSTAEKIGVIAVPEISIVRFTPSHLFFVVASDGVFEFLSSQTVVNMAAAYKDPNDACAAIAGDSYKRWLELENRTDDITIIIVQIKGLSNSGVGTTDSEVHSRPCQIGGSMNQSTAIVPPLMHQRPLESVGHSSCSFLSLYIYLSHLFFIHCATRLVDLPYTWFLCFATCVIFFIVVPAYIQPLGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PPL0</accession>
    <name>A0A0D2PPL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G059300</name>
        <name evidence="11" type="ORF">Gorai_008961</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0591969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PPL0"/>
    <dbReference type="STRING" id="29730.A0A0D2PPL0"/>
    <dbReference type="Gramene" id="KJB48232">
        <property type="protein sequence ID" value="KJB48232"/>
        <property type="gene ID" value="B456_008G059300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763177"/>
    <dbReference type="eggNOG" id="KOG1305">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NQKISHW"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031090">
        <property type="term" value="C:organelle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF643">
        <property type="entry name" value="AMINO ACID TRANSPORTER AVT6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="44"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB48232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0591969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="458" mass="49646" checksum="801C3946ABD4076E" modified="2015-04-29" version="1">MTVGDITPNKEKGSGRSKHVADEKAPLLPKQQDEDAVHDEFNGASFIGAVFNLSTTIVGAGIMALPATMKVLGLILGVALIIFMAFLTDASIEFLIRFSKAGKITSYGGLMGDAFGKYGKIMLQICVLVNNIGVLIVYMIIIGDVLSGTSSSGVHHAGVLEGWFGQHWWNGRTFVLLISTIGIFSPLACFKRIDSLRFSSALSVALAVAFLVIILAIAIFKLISGTVVMPRLLPDVTDLTSFWKLFTVFPVLVTAFICHYNVHNIANELKNTTQIGAVVRTSLASCSIVYIMTSVCGFLLFGDATLADVLANFDTDLGIPYSYLLNDAVRVSYAAHLMLVFPIVFYPLRINIDGLFFPSASPLPQSTTRFAFITSGLLILIFLGANFIPSIWVAFQFTGATAAVCLGFIFPAAVTLRDRHVISRKEDRMLAIVMIVLSVFSNMVLVYGNAISLLKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTD4</accession>
    <name>A0A0D2PTD4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G182800</name>
        <name evidence="6" type="ORF">Gorai_021433</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTD4"/>
    <dbReference type="STRING" id="29730.A0A0D2PTD4"/>
    <dbReference type="Gramene" id="KJB10074">
        <property type="protein sequence ID" value="KJB10074"/>
        <property type="gene ID" value="B456_001G182800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798577"/>
    <dbReference type="eggNOG" id="KOG0266">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6363363at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000476">
        <property type="entry name" value="Activating molecule in BECN1-regulated autophagy protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052596">
        <property type="entry name" value="AMBRA1_autophagy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874">
        <property type="entry name" value="ACTIVATING MOLECULE IN BECN1-REGULATED AUTOPHAGY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22874:SF8">
        <property type="entry name" value="TRANSDUCIN FAMILY PROTEIN _ WD-40 REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="401"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB10074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0579170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="796" mass="87007" checksum="BB5F27419BA0D494" modified="2015-04-29" version="1">MTGHPWPHDRASFRYQPSSNRRRSSKNILHLLGKREVSPRTKYVPKKLWGEAPKRNVYSSPWTEPIRDARRGILSWAEEESLQHLSGKYCPLVPPPRSTIAAAFSSDGRTLASTHGDHTVKIIDYQKGKCLKVLSGHRRTPWVVRFHPVHPEILASGSLDHEVRLWDAKTAECLGSRDFYRPIASLAFHAEGELLAVACGHKLYIWDYNKNGEGSSPAIILKTRRSLRAVHFHPHAAPFLLTAEVNDLDSSDSSMTQATSQGYFHHPPPAVFVTCGQSSDHVGLAANPSLMSLPCMIVPSFSIDDSRMDLQYISRLVGSSGTQAGHSPSMQFQTDTTMGEQYNSTASPMEAVPPIPSHLYSGSENLVNTSVAFRMETGAAEPSFDAMDTDEIQPIRESEEPNSTNRSSYSSAQRAVPRHVSDRQDATEFRPLLQFVPLGAICWELPFLQGWVMGQQTTFPSMRPHSGTGHENLTQYTASSSILQPLVGNVEAAACSLGISNSISQSGVFGRIGLQNISQSRLVSETGEVPVPSNSLHDGTDAERIISRLQSELATSMAVAAAAELPCTVKLKVWSYDIKNPCALLNVGKCCLTIPHAVLCSEMGAHFSPCGKFLAACVACVLPHSEADPRLQALVHQDGGAGTSPTRHPISAHQVVYELRIYSLEKATFGSVLVSRAIRAAHSLTSIQFSPTSEHILLAYGRRHGSLLKSIVIDGKTTSPIYTVLEVYRVSDMELVRVLPSAEDEVNVACFHPFPGGGLAYGTKEGRLRVLQYDGARDTNHNTSNYFSVENTAGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PWL2</accession>
    <name>A0A0D2PWL2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G252800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PWL2"/>
    <dbReference type="STRING" id="29730.A0A0D2PWL2"/>
    <dbReference type="Gramene" id="KJB11309">
        <property type="protein sequence ID" value="KJB11309"/>
        <property type="gene ID" value="B456_001G252800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF479">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="71"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB11309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="189" mass="22088" checksum="45C82F356B37B09A" modified="2015-04-29" version="1">MQIYQRLDRRRRFPAAVSGMSSFSSSISPKKRLGWTYWVMKKKKRVKHRQSVATTPSMALRRKRFAQEVKSYRGVRKRPWGKFAAEIRDSTRRGSRVWLAAFSMRGPLATLNFPIEAVKASLKELKYRCDEDKGWSPVVDLKNRYSLRKRSKNKKIKPKDAALRKQQNLLVFEDLGADYLEQLSISSCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYB1</accession>
    <name>A0A0D2PYB1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G234500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYB1"/>
    <dbReference type="STRING" id="29730.A0A0D2PYB1"/>
    <dbReference type="Gramene" id="KJB32308">
        <property type="protein sequence ID" value="KJB32308"/>
        <property type="gene ID" value="B456_005G234500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFETRCV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31439">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31439:SF7">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="532" mass="60011" checksum="763EA1AFA17E60AF" modified="2015-04-29" version="1">MDIWSWICELPNNGDWGESDPHPPLAFTMASSEEGDSSSTRSIQLKAERTMGSDSEVCITFTISFQGFQSSPLWVSDPCPLSSEQPFLPLVLQLLQETISRSPAMPNTICPRSQLQKLKPEPISWIIESHSPESFSSFFNLVLLTRLFWLCSWDAPSEIGSFYFQYLLGPNIEALTFKQVPVLRTFLVSTGVDTELCFMRTLGYMLTKWIILSELSVGLKTLITPLKGQQQHLGFSYATEAHGYWTLKGYAPVNAMKLLHSSDQKSQFPATGAKGSLLRYALAHQQLEAVIQLEYTIGFHDGYIQVNARVDNLRFHVARLGFSKKNDDMDDFLNEKHFPSRIRVWVGPEVGSTYVSGLTLGRSTNNGENEVETQRILKGSFGKYSKDSSHVKARARVSMKNKMKNWRWDQDAEGNAAVFDAVLCDNVTGQEIATWKSLDQNSNGSSHGFRHRYYGANRPFTKAGGLVFAGDDYGEGVGWRLNRDMEGSVLKWRIGGEVWLSYWPNNVRSSYVETRCVEWCDEVDLPLIPPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0H1</accession>
    <name>A0A0D2Q0H1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_002G041100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q0H1"/>
    <dbReference type="STRING" id="29730.A0A0D2Q0H1"/>
    <dbReference type="Gramene" id="KJB12864">
        <property type="protein sequence ID" value="KJB12864"/>
        <property type="gene ID" value="B456_002G041100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INQACTV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000590">
        <property type="entry name" value="PR5-like receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045874">
        <property type="entry name" value="LRK10/LRL21-25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27009">
        <property type="entry name" value="RUST RESISTANCE KINASE LR10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002261165" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="25"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="281"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="574" mass="65504" checksum="9A26E1F2693F67F4" modified="2015-04-29" version="1">MPKLKEKLPLFALFVILLPGVCFARHLINQDCGSTFCGNLNISFPFRIKGQPPQCGYINLELECENNNRTTLVGRGGKFSVQQIIYEDYTMRVVDASMDTDDCNSLPLSSVYDYYYDYINNYYEYKPFPFFVNDYYGRWLESSIIHVVNCTKPIKSSLYIEASRCTTKSNPPSSLPTFHFYFLNGNIHPSDINQACTVEAEVPIMVRNITGMFTLDIYKKLLEAGFFILRALLGIPCLFGLVIYKWNRRHLSMDNKIEEFLQSHSLAPIRYSFKEIKKMTKNFKYKLGEGGYGSVFKGKLRSGHYVAIKLLCKSKGNGQDFINEVASIGRIHHVNVAKLIGFCVKGSKQALVYEFMSNGSLDKIIFSEENKKTLGWKKMFDIVLGVARGVDYLHQGCDMQILHFDIKPHNILLDENFNPKVSDFGLAKLYSVKDSIVSLTAARGTIGYIAPELVYKNLGGISYKADVYSFGMLLMEMVGRRKNLNAFVDRTSQIYFPSWTYDRLDQGEDIELGDVSDDEKLLVKKMIITAFWCIKLLPIDRPSMSEVLKMLEGDVELLQMPPKPFHHLPLDTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q166</accession>
    <name>A0A0D2Q166_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G194800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q166"/>
    <dbReference type="STRING" id="29730.A0A0D2Q166"/>
    <dbReference type="Gramene" id="KJB10296">
        <property type="protein sequence ID" value="KJB10296"/>
        <property type="gene ID" value="B456_001G194800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZZZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVFDTHF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574">
        <property type="entry name" value="CALCIUM-BINDING EF-HAND FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34574:SF10">
        <property type="entry name" value="OS09G0482800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="93"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB10296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="162" mass="18309" checksum="1A1E2C378775329D" modified="2015-04-29" version="1">MHSYSPNGCFANSDIGNPIKEIERMSVEVLDCATIVNFVEDEEAFNISIRERFAHLDTNHDGLLSYTELSKDLQSLRVLETHFGIDIKTDPKELAHVYESLFEQFDHDSNGTVDLEEFKLETKRMMLAMANGMGFLPVQMVLEEGSLLKIAVEHESTKLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q397</accession>
    <name>A0A0D2Q397_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TCP-1/cpn60 chaperonin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G233100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q397"/>
    <dbReference type="STRING" id="29730.A0A0D2Q397"/>
    <dbReference type="Gramene" id="KJB10931">
        <property type="protein sequence ID" value="KJB10931"/>
        <property type="gene ID" value="B456_001G233100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0356">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERMYSSP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB10931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19109" checksum="BD8A3B7E1E852B3B" modified="2015-04-29" version="1">MATTFIAMSSVGSFVAPNGLVMDKKLSSSSYRLSSLASISSSSFLSRRNVVLRRSRLPKISAAKELHFNNDGSAIKKLQTGVNKLADLVGVTLGPKGRNVVLESKYCSPKIVNDGVTVAKEVELEDPVENIGAKLVRQAAAKTNGLAGDGATTSVVLAQGLIAEGVKLCQSKREVPSYSSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q488</accession>
    <name>A0A0D2Q488_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_006G062600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q488"/>
    <dbReference type="STRING" id="29730.A0A0D2Q488"/>
    <dbReference type="Gramene" id="KJB34363">
        <property type="protein sequence ID" value="KJB34363"/>
        <property type="gene ID" value="B456_006G062600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798696"/>
    <dbReference type="eggNOG" id="KOG0963">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="432"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="76"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="311"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="504"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB34363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="682" mass="79019" checksum="2C9B51C380273C0D" modified="2015-04-29" version="1">MDAPQGGSDGDKTNPSSSPVSVVSNFWKEFDLEKEKSVLDEQGLRIAENQENSQKNRRKLAESTRDFKKAAPEEKLSLFNSLLKGYQEEVDNLTKRAKFGENAFLNIYQKLYEAPDPYPALASISEQDLKISELESENRKMKVELEEFRTESMHLKNQQATIRRLEERNRQLEQQMEEKVKEIVEMKQRSLAEENQKTLEVLKDREQSLQDQLRQAKESVSNMQKLHELAQSQLFELRAQSEEDRAAKQSEVNLLMDEVERAQTRLFSLEREKGLLRSQLQSANEESENKRSDVDSNAILENSLSSKEKIISELNMELHNIETTLSNERVQHVNEIKKLNSLLNEKDVALEEMKKELKARPTEKLVDDLRKKVKILQAVGYNSIEAEDWEAATSGEEMSKMESLLLDKNKKMEHELTQLKVKLSEKTSFLETAEGKIVELAEKVNEQQKLIQKLEDDILKGYSSKEKKGTLFDDWDLSESGGNELSENTDQKQVSADQDQSSMLKVICNQRDRFRARLRETEEEIRQLKEKIGELTTELEKTKADNVKLYGKIRYVQDYNQEKVISRGSKKYAEDLESGFTSDVESKYKKIYEDDINPFAAFSKKERDQRYKELGFRDRITLSSGRFLLGNKYARTFAFFYTIGLHILVFTCLYRMSALSYLSHGSEETAVVEKNLNLPRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q7D2</accession>
    <name>A0A0D2Q7D2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2 8">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G162200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 8">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2 8"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q7D2"/>
    <dbReference type="STRING" id="29730.A0A0D2Q7D2"/>
    <dbReference type="Gramene" id="KJB15129">
        <property type="protein sequence ID" value="KJB15129"/>
        <property type="gene ID" value="B456_002G162200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEQQLTY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:cytokinin riboside 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000005">
        <property type="entry name" value="CASP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF69">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="189" mass="20536" checksum="E5B98B8CD985609B" modified="2015-04-29" version="1">MEMENETQQSKFRRICVFCGSSQGKKSSYQDAAIELGRELVSRNIDLVYGGGSIGLMGLVSQAVRDGGRHVIGVIPKTLMPRELTGETVGEVKAVADMHQRKAEMAKHSDAFMALPGGYGTLEELLEVIAWAQLGIHDKPVGLLNVDGYYNSLLSFIDKAVEEGFISPSARQIIVSAPTAKKLVKKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8R3</accession>
    <name>A0A0D2Q8R3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G125100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8R3"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8R3"/>
    <dbReference type="Gramene" id="KJB35713">
        <property type="protein sequence ID" value="KJB35713"/>
        <property type="gene ID" value="B456_006G125100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799359"/>
    <dbReference type="eggNOG" id="ENOG502QQCP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EANMSIM"/>
    <dbReference type="OrthoDB" id="512036at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31482">
        <property type="entry name" value="ESTS AU081301(E20138)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31482:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266123" description="F-box domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="87"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB35713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="397" mass="46338" checksum="82B746425EABD146" modified="2015-04-29" version="1">MLLLYFFLTCFPIIFLFKLKKSLPPWDTEVKLLSLWFGKDVSFSSVTKFIKTSSSLCYFTSKMSLKKMSLTSKVDNFEEEVVEEGAAMSILDLPELVLESILERLPPASLCSMAGVCSSLRSRCITDHFWEKHMKNKWGRIIGPVAYREWQWLIALRKDSSHLKQWRPKGLMRIFSIVRPSWWIKPKVDDCSKQSSLPRESIMSWFLALETGRFCFPAQVYNRENGHVGFMLSCYDAELCYDQRTDTFQARYPPHGRRAVAIENNVPWERIRAPPVDTSPHDLHISDCLNELRPGDHIEIQWRRNKEFPYGWWYGVVGHLASCDGNENYCRCHNSDTVVLEFNQYALGSRWRHTTIDRKEHREEGNEGDGFYGGIRKLGSVEEISTWKRLWPAEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8Z9</accession>
    <name>A0A0D2Q8Z9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G044200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8Z9"/>
    <dbReference type="SMR" id="A0A0D2Q8Z9"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8Z9"/>
    <dbReference type="Gramene" id="KJB54672">
        <property type="protein sequence ID" value="KJB54672"/>
        <property type="gene ID" value="B456_009G044200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771239"/>
    <dbReference type="eggNOG" id="KOG0749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTASMNT"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000071">
        <property type="entry name" value="probable ADP,ATP carrier protein At5g56450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF31">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="133"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="235"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB54672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="324" mass="36304" checksum="61D9820B9D73703E" modified="2015-04-29" version="1">MSKEEDGGLDNRGWLRSSSGAYKWLASFHRDLMAGAVMGGVVHTIVAPIERAKLLLQTQESNLAIVAGRRRKFKGMFDCIFRTVREEGTLSLWRGNGSSVLRYYPSVALNFSLKDLYRNILRNGCFQDGHVFSGASANFIAGAAAGCTTLIIIYPLDIAHTRLAADIGRTDVRQFRGIYHFLSTMYKKDGIWGIYSGLPASLHGMIVHRGLYFGGFDTMKEILSEKSRNELALWKRWVVAQAVTTSAGLLSYPLDTVRRRMMMQSGLEKPMYHSTLNCWRTIYRTEGVTSFYRGAVSNVFRSTGTAAILVLYDEVKKFMNWGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEM6</accession>
    <name>A0A0D2QEM6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G174400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEM6"/>
    <dbReference type="SMR" id="A0A0D2QEM6"/>
    <dbReference type="STRING" id="29730.A0A0D2QEM6"/>
    <dbReference type="Gramene" id="KJB15381">
        <property type="protein sequence ID" value="KJB15381"/>
        <property type="gene ID" value="B456_002G174400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785659"/>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQQDHHD"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000003">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF39">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="128" mass="14596" checksum="E0BBE84BB9390B98" modified="2015-04-29" version="1">MDGAELELERRSKFLNSLIQKKKAIEQQEQNEHLNVKVRASDMPLALQNKAFKCARDQLDYMPGKLDSKRLALALKKEFDSTYGPAWHCIVGTSFGSYVTHSLGGFLYFSIDKVYILLFKTAVEPLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEV7</accession>
    <name>A0A0D2QEV7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G127500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEV7"/>
    <dbReference type="STRING" id="29730.A0A0D2QEV7"/>
    <dbReference type="Gramene" id="KJB56612">
        <property type="protein sequence ID" value="KJB56612"/>
        <property type="gene ID" value="B456_009G127500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHEMRIE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053293">
        <property type="entry name" value="OCM_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47209">
        <property type="entry name" value="OS06G0639500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47209:SF4">
        <property type="entry name" value="SEED DORMANCY CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOG1" evidence="1">
        <location>
            <begin position="62"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB56612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="500" mass="56751" checksum="E861EFB0E8241701" modified="2015-04-29" version="1" fragment="single">KEIGKKHKKKESGRVIDEIIDKFHCMNIVKREANQRDCSNEQHELLTPQKRSKARFRNHDVPGLHREKHGLWRQEQKSRAAKIEKQLKARRELEALIEEQLNRFHAHYNQAMVPSHLEDVSKLLRPQWAAPQELASLFWLGDWRPSAILELLHGLAPLSFLSDSTASAMQPAISQFIHEMRIEEAVIDEEMAEIQATCVLYLPFAPVNSSKSGGSASHGIQSEFLKIARVITKAQKLRFKALELVVKKLLNQTEAAEFLVAFSGIQDAIHQFAEEKRLRKGPVTVSVKSHDVTETSKQPKIHIDDRISHLLKTSDSSEYGQGIQYALSEFEELQGLQKGSVTQSARFQDVVETSNQPKIPLEDRTSSWDNLSKTSDSLEHGQGIQYALCEFEEQEALRKGPVTQSVRSQDVVETSNQPKIPLEDRMGLWDSLCHLLEQDSSGERIIDDINEPAGLPIESWDVVETSKQPMIHSEDRIGLWEMFSKMVGDMKSGQGIPRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QHA5</accession>
    <name>A0A0D2QHA5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G263900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QHA5"/>
    <dbReference type="STRING" id="29730.A0A0D2QHA5"/>
    <dbReference type="Gramene" id="KJB38628">
        <property type="protein sequence ID" value="KJB38628"/>
        <property type="gene ID" value="B456_006G263900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797998"/>
    <dbReference type="eggNOG" id="KOG0869">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSVGFKE"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000049">
        <property type="entry name" value="Nuclear transcription factor Y subunit B-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF149">
        <property type="entry name" value="OS01G0935100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0938">Abscisic acid signaling pathway</keyword>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="10">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB38628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="143" mass="15729" checksum="7A60B441E96C24B4" modified="2015-04-29" version="1">MAENAGTSGTTSNNGNSVGFKEQDQLLPIANVGRIMKQILPPNAKISKEAKETMQECASEFISFVTGETSEKCKKERRKTVNGDDICWALATLGLDDYAVPLKRYLLRYRELEGEHKPAANHDKVAIVDNCNVEDGDNMGPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJT6</accession>
    <name>A0A0D2QJT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G268700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJT6"/>
    <dbReference type="STRING" id="29730.A0A0D2QJT6"/>
    <dbReference type="Gramene" id="KJB17186">
        <property type="protein sequence ID" value="KJB17186"/>
        <property type="gene ID" value="B456_002G268700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIAVEXX"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB17186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="299" mass="34296" checksum="3DA37D5239B40121" modified="2015-04-29" version="1">METEVMVAGSIDGSMYQGWFNTEGYLLRLPLLECWVVSKLHMLIDAVTESYNKYFFGDVGREIYDFFWGDFADWYIEASKATIYHSGDDSVALVAQTVLLYIFEHILKLLHPFMPFVTEELWQALPNRREALIISSWPQTSLPRSTDLVKRFENLQALTRAVRNARAEYSVEPAKRITASIVGSEEVIQYISEEKEVLALLSKLDFDNIHFADSPPEDAKQSVHLIASEGLEAYLPLADMVDISAEVQCLSKRLSKMQTEYEGLKARLNSPKKTKVSLLWMSAIHIYPRHERIQKHTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLV6</accession>
    <name>A0A0D2QLV6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Synechocystis YCF37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G052200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLV6"/>
    <dbReference type="STRING" id="29730.A0A0D2QLV6"/>
    <dbReference type="Gramene" id="KJB40228">
        <property type="protein sequence ID" value="KJB40228"/>
        <property type="gene ID" value="B456_007G052200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802208"/>
    <dbReference type="eggNOG" id="ENOG502S113">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HCEHTSH"/>
    <dbReference type="OrthoDB" id="782330at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36734:SF1">
        <property type="entry name" value="OS02G0815300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36734">
        <property type="entry name" value="YCF37-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB40228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17927" checksum="5105D450BAC437D7" modified="2015-04-29" version="1">MASTISPPMFHALSVHGVHTSHRGRSVKVHVSKPSPVVSLSNRRQLLFFMTTTTALTVRERESNAEDIPLFGFRKKLKSAEEEAVEIVKEGLETAEKGLETAERGIFTVEKGLKTAEKKIETAEKEIESAVGFGALAQAGAVAVAEFLGVVVATSIVNGVLAAEAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSI1</accession>
    <name>A0A0D2QSI1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G141500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSI1"/>
    <dbReference type="STRING" id="29730.A0A0D2QSI1"/>
    <dbReference type="Gramene" id="KJB42193">
        <property type="protein sequence ID" value="KJB42193"/>
        <property type="gene ID" value="B456_007G141500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803153"/>
    <dbReference type="eggNOG" id="ENOG502QX6A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAFRTGH"/>
    <dbReference type="OrthoDB" id="664875at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020983">
        <property type="entry name" value="Basic_leucine-zipper_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46408:SF5">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46408">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12498">
        <property type="entry name" value="bZIP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="214"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB42193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="429" mass="46253" checksum="969576242E98D45F" modified="2015-04-29" version="1">MNTVFSVDDFSDSFWAAPASDDALGMTRSHSEWALERFLEEFSGAGVAISGSHAGENVIGPSLMAPQSSVSKVEEGDVVEIKRPNSQNHNHPPSDQTPTVPTASDDYHTILKSKLELECAAVALSRALAVKAEDSSAEAENHGLPSGSKVQGSSKVQGQGETDVAHCGTLTGSTTQKKSGVQVRQATSGSSREDSDSDELEGDTETADNMDPADAKRARRMRSNRESARRSRRRKQAQLNELEAQVGQLRVEHSTLLKRLTNMNHKYDEAAVDNRIMKADIETLRAKVKMAEETVKRVTGFNPALLSRPNVPSVGMPFVSNPLEASTVAPLPFQSNANQFFNQPVPNIVASIHHQRVDNSFRGNTLVPPDVNSQTKGVKNVNETSVLQHGPSLDCVPDQIGPGVSPCGPMPGWEPGLLPHAGDRNNKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSS4</accession>
    <name>A0A0D2QSS4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G339200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family. ICK/KRP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSS4"/>
    <dbReference type="STRING" id="29730.A0A0D2QSS4"/>
    <dbReference type="Gramene" id="KJB61067">
        <property type="protein sequence ID" value="KJB61067"/>
        <property type="gene ID" value="B456_009G339200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766052"/>
    <dbReference type="eggNOG" id="ENOG502QXA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSVCRFI"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044275">
        <property type="entry name" value="KRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46776">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017811">
        <property type="entry name" value="CDK_inhib_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="6">
        <location>
            <begin position="203"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB61067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="249" mass="28135" checksum="06DDE5BAC53D4394" modified="2015-04-29" version="1">MGKYIRKAKSTMEVAVMDVSQSSFGVRTRAKTLALQRLQKSSTSPETAGASPTPDFSDDSYLQLRSRRLEKPPVVLRHHDSKRLKQQGIKDGCGENPSPNSNFRVRLGKDDGVEREEFVQETIGNDNIINIVNNNESEDFGGIEASLGENLSDIEARERGYRESTPCNLIRDPEGIRTPGSTTRPTSSAETNQRVHNSVRGHIPTAHEMDEFFSIAEEEQQRQFIEKYNFDPVKDKPLPGPYEWEKLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0Y4</accession>
    <name>A0A0D2R0Y4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_004G080500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0Y4"/>
    <dbReference type="STRING" id="29730.A0A0D2R0Y4"/>
    <dbReference type="Gramene" id="KJB23091">
        <property type="protein sequence ID" value="KJB23091"/>
        <property type="gene ID" value="B456_004G080500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000935">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
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    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="313"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="17">
        <location>
            <begin position="442"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB23091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="662" mass="73764" checksum="F054F8FFCA965BDD" modified="2015-04-29" version="1">MPSRSAAGVRTGVRVVVAGDRGTGKSSLISAAASDAFPEYVPAVLPPTRLPSDFYPDGVPVTIVDTSSSMESRIKLIDELKRADAVVLTYACDQPMTLSRLSSFWLPELRKLEIKAPVIVVGCKLDLRDERQPMNLEQVMAPIMQQFREIETCIECSSATLIQVPDVFYYAQKAVLHPTAPLFDQEKQTLKPRCIRALKRIFMLCDHDMDGALSDAELNEFQVKCFNAPLQPAEIVGVKRVVQERIRGGVSDLGLTLEGFLFLHALFIEKGRLETTWAVLRKFGYNDELKLRDDILPVPTKHAPDQTVELTNEAIDFLRGIFRLYDSDNDGSLQPSEFDDIFVTAPESKTLEALTIYFYCFNLLIFVFFPWTVDPYVDAAERTPQGNLTINGFLSEWALMTTLDPSYCLANLICIGYGGDPTSALRVTRRRSVDRKKKQTEKNVFHCFVFGPKKSGKSALLNSFIGRTFSSNYTPTNDVRYVANAVEQIGGSQKTLILQEIPEDGVKKLLSNKECLAACDVAVFLYDSSDEYSWKRSRELLLDVARRGEESGYGVPCLLIAAKDDLDPFPMSLQNSARVTQQLGMEAPIPVGVKLRDSKSVFSRIVSAAEHPHLSIPETEKGKKRKRYRRLVNSSLMFVSVGAAVAVVGLAAYRAYAARKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3Q4</accession>
    <name>A0A0D2R3Q4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G339900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R3Q4"/>
    <dbReference type="Gramene" id="KJB45948">
        <property type="protein sequence ID" value="KJB45948"/>
        <property type="gene ID" value="B456_007G339900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NQHCYMF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF48">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250811" evidence="14">
        <location>
            <begin position="26"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="15">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="16">
        <location>
            <begin position="291"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB45948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="960" mass="106379" checksum="226A8C49060F20ED" modified="2015-04-29" version="1">MKSVTITLFPFLLVILANCFSFCDANSNVLCFESERKALLKFKNDLVDPSNRLSSWVEGGGCCKWLGVVCHNSTGHINQLHLAAPLSVAHFDAPVAEWEAYHRSKNNSLLGGKINPSLLELKHLSSLDLSNNNFSGIQIPKFFGLLESLSYLNLSQARFQGAIPHNLGNLSKLQYLDLGGNDLKPKSLQWVSGLSSLQYLDLSHADLSKATDWLQVTFQHPSLLELHLSACSLEDDASPISVNSTKSLVVLDLSENNFSSVPMSIFGLHDLVSIDLSGNSLKGPIPDYFTNISLLEVLDLSGNSLNSSTPTSLFSLYHLQFLNLSSNEIDQDISQILLSLSRCCLDCLESLDMAHNHLFGHLIDQLGHFKNLAHLSLAGNNISGPIPLSIGELSSLKLFNVSENQLNGTFPLCFGQLKSLETLDLGCNQLEGVVSETHFSNLRRLTTLAASQNRLRFEPNSSWIPPFQCRIIRLGQWHLGPKFPRWLKFQKNLSVLDISDAGISDILPTWLLNLSTQFEYVNLSCNQLTGGISYLNVTEIVDLSSNRFTGPLPRVFTTLQILILSNNSFSGRLVELVCYSLRKGPMRILAIETNLLSGEIPDCWDHWRGLGYLNLENNKLTGKIPPSLGHLNLLVLNLRSNGMSGELPSTLQHSTRLIMLDLSDNHFSGSVPTWIGDKLSKLEILSLRSNNFDGHLPQKICQLQSLRILDLGHNNISGAIPKCFSNFSAMANKSNQHCYMFQWSSISTNFLYLSALLVLKGREDEYGATLGLVTSMCLSTNRLIGEIPKELGSLVELRSLNLSGNLLIGNIPDEIGNMKLMESLDLSRNQLNGEIPPSFSKLNFLNHFNVSYNNLIGQIPTSTQLQSFESLSYVGNHLCGPPLTKNCSSKGFSTDVANNGSNSEGSKVNWLYVSIVLGFVMGFWGVVAPLFFIRSWRHAYYRKLDNVYGKLYVFWATMGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R555</accession>
    <name>A0A0D2R555_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G369600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R555"/>
    <dbReference type="Gramene" id="KJB46453">
        <property type="protein sequence ID" value="KJB46453"/>
        <property type="gene ID" value="B456_007G369600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB46453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="173" mass="20124" checksum="3F4BE65AD02277FA" modified="2015-04-29" version="1">MTPTTSESSSLPDAEERSATSNFTAWLGKLKDAPYDADDLLHELSFDVFRRLLFPWSRANNYVYLPTMSSQIQVTKNRLTSSERVLDMLNFFNHLLVKFPLMAAKITTLEAGCPTRMKTTEKLSLWQIKITKFYSKSRNKDKLSLTNEFLCFSCFTHRRRRPFLCLLFTDIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R6I8</accession>
    <name>A0A0D2R6I8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G175000</name>
        <name evidence="9" type="ORF">Gorai_015004</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R6I8"/>
    <dbReference type="STRING" id="29730.A0A0D2R6I8"/>
    <dbReference type="Gramene" id="KJB25061">
        <property type="protein sequence ID" value="KJB25061"/>
        <property type="gene ID" value="B456_004G175000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791803"/>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPSRKTP"/>
    <dbReference type="OrthoDB" id="2017408at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009534">
        <property type="term" value="C:chloroplast thylakoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009840">
        <property type="term" value="C:chloroplastic endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000001">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009205">
        <property type="entry name" value="PRK12553.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF24">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB25061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0584179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="288" mass="31053" checksum="99FB1C92F35E3E9A" modified="2015-04-29" version="1">MGLLSLSSSLTPSFSSLHLKPKHKLSLTFPNPSFVCSAPTSTPLSSSLKLKPTANSLKLSAPQSPATAMRGAEADAMGLLLRERIVFLGNNIDDFVADAIISQLLLLDAQDPTKDIRLFINSPGGSLSATMAIYDVVQLVRADVSTVGIGIAASTASIILGGGTKGKRFAMPNTRIMIHQPLGGASGQAIDVEIQAREIMHNKNNVTRIISASTGRPFEQVLKDIDRDRYMSPIEAVEYGIIDGVIDRDSIIPLEPVPERVKASLNYEEISKDPRKFLTPDIPDDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R7F2</accession>
    <name>A0A0D2R7F2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Agglutinin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G011900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R7F2"/>
    <dbReference type="Gramene" id="KJB27824">
        <property type="protein sequence ID" value="KJB27824"/>
        <property type="gene ID" value="B456_005G011900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QU8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KYWAAKQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00257">
        <property type="entry name" value="beta-trefoil_FSCN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20216">
        <property type="entry name" value="PFM_HFR-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008998">
        <property type="entry name" value="Agglutinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036242">
        <property type="entry name" value="Agglutinin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053237">
        <property type="entry name" value="Natterin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244:SF5">
        <property type="entry name" value="NATTERIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244">
        <property type="entry name" value="NATTERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07468">
        <property type="entry name" value="Agglutinin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00791">
        <property type="entry name" value="Agglutinin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50382">
        <property type="entry name" value="Agglutinin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agglutinin" evidence="1">
        <location>
            <begin position="142"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Agglutinin" evidence="1">
        <location>
            <begin position="290"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB27824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="602" mass="68331" checksum="184A6D9C256CCEAD" modified="2015-04-29" version="1">MAIEWPKFMVLKCEARNKYLSYMRENCDCNGYLKFSETLAFSPYTKFQVERAKCSTGEDGLVHIKSCHNNKYCKRVKNVSITGNSKEQYYLISAAARKPEEGGSEESCTLFKLIPVDTATNKIRIMHVKSVIDWELLANKPFASPRFIVLKSRQNNKYLGFDHENGDYKHGYLKFSETRVASPYAKFEVEIAQRGGIDGLVHIRSSQNNKYLVSDGTRITATAKKPEEDRSKNSCTLFKLISVDDAANEVQIVHVQSRKYLWVKRENPNLFTSEHLDENMFTIIDWESLVFLPRHVAFKGNNGQYLCLRQIEGHPYLQFSSGDIGDAGVTMEVSMNNDGSIRIKPACSNKFWRRSSNWIWADSDDTTSNNKDTLFRPLKVNNRTIALRNLGNNNFCKSLSMEGKTNCLNADVSSITKEVQLRVEVPVLERTIYDIKYDLGNCRIYDESKLVIATNSACNYTQKSESLELKLSYTDTHTRTWKANVSLKVGPKATMNFGLPKIFEGRIDVLSGETQTGFEWEDTKTVTSVVYVLQKLVVPPMTKVTVNLTAINGTCDVPFTYMQKDTLYNGNIVSEVQGGTYTGSNYYSLDFQTKKESLSSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAK1</accession>
    <name>A0A0D2RAK1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G218600</name>
        <name evidence="11" type="ORF">Gorai_023415</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2RAK1"/>
    <dbReference type="Gramene" id="KJB16230">
        <property type="protein sequence ID" value="KJB16230"/>
        <property type="gene ID" value="B456_002G218600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786121"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNEMSDD"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Myb transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="EOBI/EOBII-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
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        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TRANSCRIPTION FACTOR MYB62"/>
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    </dbReference>
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        <property type="entry name" value="Myb_DNA-binding"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="20"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="73"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="73"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB16230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0581232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="304" mass="34501" checksum="8A60BF2EDC711BEA" modified="2015-04-29" version="1">MRAAMPPINTKNMSTPLEEESELRRGPWTLEEDTLLTHYIARHGEGRWNMLAKCAGLKRTGKSCRLRWLNYLKPDIKRGNLTPQEQLLILELHSKWGNRWSKIAQHLPGRTDNEIKNYWRTRVQKQARQLNIESNSQRFLDAVRCFWMPRLVQKVEQASPSSSSSSSSSYLKEMCTQSSVPSQLSSCCTVPSFPTVSPLANKTTDISNSSSVTTQNICPTDSINNISDQTEIPQHLTGSNVYGHTTLDQCYNIDSNDYGMEGISFASMSGVGFYEGTPSEGNWMCNEMSDDLWNMDDIWQLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RCD1</accession>
    <name>A0A0D2RCD1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase (cysteine targeting)</fullName>
            <ecNumber evidence="17">2.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Peroxin-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_010G229600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-S-ubiquitinyl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
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    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2RCD1"/>
    <dbReference type="SMR" id="A0A0D2RCD1"/>
    <dbReference type="STRING" id="29730.A0A0D2RCD1"/>
    <dbReference type="Gramene" id="KJB68162">
        <property type="protein sequence ID" value="KJB68162"/>
        <property type="gene ID" value="B456_010G229600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774288"/>
    <dbReference type="eggNOG" id="KOG2879">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHGLMEL"/>
    <dbReference type="OrthoDB" id="1701437at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16526">
        <property type="entry name" value="RING-HC_PEX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045859">
        <property type="entry name" value="RING-HC_PEX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48178:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 18" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB68162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="345" mass="39899" checksum="250606F26AEB3F3E" modified="2015-04-29" version="1">MISFRSNPSTAPPPREDAWITSYQKLLPHWHSVSLSHQHSTLPISISRVNQFDAARLDIEMSAMLKEQLVKVFSLMKPGMLFQYEPELDAFLEFLIWRFSIWVDKPTPGIALMNLRYRDERAVEIRENVRTGLEGPGLTVAQKMWYCIAAVGGQYIWARLQSFSAFRRWGDSEQRPLARRVWGLMQRIEGLYKAASFGNLLLFLYTGRYRNLIERALRARLVYESPNMNRAVSFEYMNRQLVWNEFSEMLLLLLPLLNSSTVKSVLHPFSKNKSSSSTEDDSTCPICRASPTTPYLALPCQHRYCYYCLRTRCAAAPSFRCSRCSEPVVAMQRHGSIVEHKTHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF16</accession>
    <name>A0A0D2RF16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G014400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF16"/>
    <dbReference type="STRING" id="29730.A0A0D2RF16"/>
    <dbReference type="Gramene" id="KJB17765">
        <property type="protein sequence ID" value="KJB17765"/>
        <property type="gene ID" value="B456_003G014400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787533"/>
    <dbReference type="eggNOG" id="KOG0073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWCILAC"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB17765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="185" mass="21061" checksum="37A73BC63F7F8560" modified="2015-04-29" version="1">MGLLSIIRKIKRKEKEMRILMVGLDNSGKTTIVLKINGEDTSIISPTLGFNIKTISYQKYTLNIWDVGGQRTIRSYWRNYFEQTDGLVWVVDSSDLRRLDDCKMELDNLLKEERLSGASLLILANKQDIKGALTPAEIAKVLNLEAMDKSRHWKIVGCSAYTGEGLLEGFDWLVQDVASRIYMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RG28</accession>
    <name>A0A0D2RG28_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G163900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RG28"/>
    <dbReference type="STRING" id="29730.A0A0D2RG28"/>
    <dbReference type="Gramene" id="KJB30809">
        <property type="protein sequence ID" value="KJB30809"/>
        <property type="gene ID" value="B456_005G163900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794461"/>
    <dbReference type="eggNOG" id="ENOG502RYTJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFPDIMG"/>
    <dbReference type="OrthoDB" id="1937859at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31903">
        <property type="entry name" value="F12F1.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31903:SF4">
        <property type="entry name" value="OS11G0490300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="250" mass="27487" checksum="C44399389A41E98C" modified="2015-04-29" version="1">MKLKNKGKVYPSPSSSSSSSEDHLSVLNLLPAAILVVASVLSLEDRQVLAYMITRSLKTTTTNPSLISPKKRSSKKHPPPSAARPSHQPPDFDCDCFDCYTTYWLRWDSSPNRELIHQVIEAFEDHLSSGESHKPSKKNARLKRRAANTKTVSRIPKNPVSDLPGHQVPVSTEEAPVFADDVISTEKNVGEESAAAVEMTEEYPVAGDSDVEVGTRPPPTSNHKGLARKVLPDILGLFNSRLWGLWSPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIX4</accession>
    <name>A0A0D2RIX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Vignain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G203800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIX4"/>
    <dbReference type="STRING" id="29730.A0A0D2RIX4"/>
    <dbReference type="Gramene" id="KJB51148">
        <property type="protein sequence ID" value="KJB51148"/>
        <property type="gene ID" value="B456_008G203800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIGFCRA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018721556" description="Vignain" evidence="7">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="9">
        <location>
            <begin position="41"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="8">
        <location>
            <begin position="129"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB51148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38585" checksum="5225B4698DDABCAF" modified="2015-04-29" version="1">MKTVNAVLSVVVAMALVLGIAESFDFHDKDLASEESLWDLYERWRSHLMVSRSLDEKHKRFNVFKQNVKHVLHTNNDNKPYKLKLNKFADMTNHEFRNAYASSKIRYHRMFQGTPRGTRSFMYENVNNVPTSVDWRKRGAVTAVKDQGHVTNKLVSLSEQELIDCDTEENQGCNGGLMDIAFDFINKKGGITSEIHYPYAAKQGTCDVSKENSPVVSIDGHENVPVNDEEALRKAVANQPVSVAIDAGGTDLQFYSEGVYTGQCGIEQNHGVAAVGYGTTLDGTKYWIVKNSWGPDWGEKGYIRMERGIKDKQGLRGIAMEASYPIKNSSSNPTTPSFYPKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKP5</accession>
    <name>A0A0D2RKP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Pachytene checkpoint protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G115100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Plays a key role in chromosome recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKP5"/>
    <dbReference type="STRING" id="29730.A0A0D2RKP5"/>
    <dbReference type="Gramene" id="KJB19695">
        <property type="protein sequence ID" value="KJB19695"/>
        <property type="gene ID" value="B456_003G115100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788623"/>
    <dbReference type="eggNOG" id="KOG0744">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NVCDSVQ"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19508">
        <property type="entry name" value="RecA-like_Pch2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000680">
        <property type="entry name" value="pachytene checkpoint protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23563">
        <property type="entry name" value="TRIP13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="191"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB19695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="457" mass="51023" checksum="12F9CD7D97AE088E" modified="2015-04-29" version="1">MSSPMDISVPNLEGVKISDQNGVPLAPPPASPSNVPHEKFQVSVEVCLKPSSTARPDDVQKAVEQMLEKRSLSYVDGPIPVPNDDPFLMENVHRICICDTDEWVKNHDILLFWQVKPIVHVFQLSEEGPCEELTGDGQLSSFNEWILPAKEFDGMWESLIYESGLKQRLLRYAASALLFTEKGVDPFLVSWNRIILLHGPPGTGKTSLCKALAQKLSIRFSSRYPQCQLIEVNAHSLFSKWFSESGKLVAKLFQKIQEMIEEENNLVFVLIDEVESLAAARKAALSGSEPSDSIRVVNALLTQMDKLKSSPNVIILTTSNITAAIDIAFVDRADIKAYVGPPTLQARYEILRSCLQELIRTGIISNIQGSSQYILSDYVTLKEKLNMHEIQEAQTTFHLCKQLAEAAEACEGLSGRTLRKLPFLAHAELDNPYCCDPNKLLNTMIDTARRERSELPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQB0</accession>
    <name>A0A0D2RQB0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">B456_005G207900</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQB0"/>
    <dbReference type="Gramene" id="KJB31771">
        <property type="protein sequence ID" value="KJB31771"/>
        <property type="gene ID" value="B456_005G207900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KDEMECK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000005">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000330">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase At4g03230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021820">
        <property type="entry name" value="S-locus_recpt_kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1111">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11883">
        <property type="entry name" value="DUF3403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 20" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 23" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250380" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="22"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="602"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="26">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="27">
        <location>
            <begin position="339"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="696"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="987"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="998"/>
            <end position="1007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KJB31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1014" mass="113477" checksum="9CDF1E932C9FA669" modified="2015-04-29" version="1">MLPSLILHTLVFCSYILCSSAKETITSNSSISDGEGDSLVSPGKKFELGFFTPNGSSNTRRYLGIWYYGSNPQTVVWVANRDKPLLDDSGVFVVGEDGNLKMLNGNGESFWSTNLKAVPSGYKKAKLTDTGNLVLFNEEQESHSESIIWESFHNPTDTFLPGMRMDENMVLTSWKSFDDPAPGNFTFQIDQERVNQFIIWKRTTRYWKSGVSGKFIGPDGMPSAMPSAISFFLSNFTTVVLHNESMPHLTSSLYSDTRMIISFSGQIQYFKWDSRKIWSVIWAEPRDKCSIYNACGNFGSCNSNNDLMCKCLPGFAPSSPANWNNQDYSDGCTRNSRICNKKAKIDTFLSLNMMEVGNPDSQFNAKDEMECKFECLSNCQCQAYSYEEPDNMQQGGSRFAACWIWLEDLNNIQEEYEGGRNLNVRLPVSDVESTRRSCETCGTNLIPYPLSTGPKCGDAMYLNFHCNISSGEVTFDVPIGTYRVTSISPETRKFIIQTNDANDCKAGNSGDDLFRFKQPSPFHVTSRCNADEVEIGWDPPLEPTCSSPTDCKDWPNSTCNGTSNGKKRCLCNTNFQWDNLSVNCTEDSGYGQKKYKSSTRKIALSLTLVIACISAIVITIVSSAIGYVYLKRRKQVEGEGIWGNIQRKSALHLYGSASERHVKDLIDSGRFKEDDTDGIEVPFFHLESILSATRNFSNANKLGQGGFGPVYKGKFPGGQEIAVKRLSSGSGQGLEEFKNEVVLIARLQHRNLVRLLGYCVAGDEKMLLYEYMPNKSLDSFIFDRKLCVLLDWDMRYRIILGIARGLLYLHQDSRLRIIHRDLKTSNILLDEEMNPKISDFGMARIFGGKETSANTNRVVGTYGYMSPEYALDGLFSFKSDVFSFGVVVIEIISGKRNTGFYQPEQSLSLLGYAWHMWKTGKAMDLLDQTLRESCKADELLKCLNVGLLCVQEDPGDRPTMSQVVFMLGSENASVPAPKQPAFVVRRCPSSKASSSSKPETFSQNELTVTLEHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRI6</accession>
    <name>A0A0D2RRI6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 4G</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein synthesis initiation factor 4G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G038200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2RRI6"/>
    <dbReference type="Gramene" id="KJB21745">
        <property type="protein sequence ID" value="KJB21745"/>
        <property type="gene ID" value="B456_004G038200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21746">
        <property type="protein sequence ID" value="KJB21746"/>
        <property type="gene ID" value="B456_004G038200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790302"/>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSHPIAP"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000024">
        <property type="entry name" value="Eukaryotic translation initiation factor 4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="1687"/>
            <end position="1811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="640"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="716"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="892"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1074"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1324"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1498"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1637"/>
            <end position="1685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="62"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="201"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="563"/>
            <end position="605"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="640"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <begin position="666"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="716"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="740"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1080"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1667"/>
            <end position="1679"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00067320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB21745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1875" mass="203501" checksum="61F615A72182CF5F" modified="2015-04-29" version="1">MSFKQSRSDKSEQQQYRKLGRSASSNQQQRTSSGGYGEGGGGGPAPSSSLSSSSSSSRSFKKSNNAQGGQPRVNTPAVNSTESSNASAARNIQTGARVQPQLQGASNMPVASGVAKPVGPPANQRSTQAVPKAPTSQSATLSSDSSFSTHPTKGDASQAFSLQFGSISPGSMNGMQIPAQTSSAPPNLDEQKRDQAFHGSSVKSVSNLPTTVPRQQLPRKDSVATGQSNSGEAHPMPMVKKDVQASAGPAVNQTQKSSHLNIPMASMQMPFHHQPQVPMQFGVTNPHIQSQSPSVSATSIQMPLYMPIPMENDPQVMQQQLLVPGLSPHPLPLQGMMHQGQGLSYTPPLGGQLAPQLGNLGMGIAPQYPQQQGGKFSVPRKTTVKITHPLTREELRLNKQTDTYLDSGSSGPRSHPIAPSQSQPVPSFAPHSINYYSNPYNTNSIFYPPPNTLQLSSSQIAVAPNAQGLRFNYPVGQSLQNISYMNSAAGHGSLPANKPVNLKHGTLESPSVELACDVHDVASSASSGITQVTVKPAIVSAGEKVTDSSLSINLPPVEKVGSLKSSVPSSDGSLSQAQRDLDTCQESSVQQPKCESESLASNSLPATAKRVQATNLDEFVSPAPAAMSEESVRVVVSNDSGRDSLTYSNSVKDYQKKPGKEGHIQPPNQSMSTSYLASHTAEHSMSSDSAVSDTIRAKTALVSSSAAYVLPQPTKKLTSINGSSTSSIDLRTDRKREGLTSDSSEVSGTGSNVDCLDMVQHANIDGSSKLDEQLKPEINRIKDPLKSMELESDQNSALKASSTSDIVPTFVTARPMLDEDVGASIENKRVSDSMDFSSSKVSESTDLESSHVVITFGSNASAKAIDSNEVTVTKSGASDQQSTLVTTTDLFDSSSKYEGGGVPVPSSKDKTALDLSRTKSTSAKGRKKRQEFLEKADAAGTTSDRYIAFKSPEEKKETVVPSASAESNCTGVDLKLVSHESPQVDSTGSEELAQDKAQLDDWEDVADSCAPKLETSNNGEKAHEGLINIEKDGSGNISKKYSRDFLLKFAEQCTDLPQGFEIASDIAEPLMTPNVNGSHLVDRDSYPSPGRKMDRQSSGSRLDRRGSGMVDNERWVKLPGSFRPGRDLRLDPSYGAAASFQPVQGGNFGIVRHPRAQTSLPFVGGILAGPMHPMGLQGGMPRNSPDTDRWQPVANYSQKGLISSPQTPLQTMHRAARKYEMGKVTDEETLKQRQLKAILNKLTPQNFEKLFEQVKAVNIDNAVTLKGVISQIFDKALMEPTFCEMYANFCYHLAGELPDFSEGNEKITFKRLLLNKCQEEFERGEREQEEANKVEEVGEAKRSEEEREEKRVKARRRMLGNIRLIGEVYKKKMLTERIMHECIKKLLGEYENPDEEDIEALCKLMSTIGEMIDYPKAKVYMDAYFERMAKLSNNVKLSSRVRFMLKDAIDLRKNKWQQRRKVDGPKKIEEVHRDAAQERQAQASRLAHGPGINPAARRAPSDFGPRASVLSSPGPQVGSFRGSSTQLRGFRAQDARMDDRLRIETRTLLVPLPQRPVGDDAIALGPQGGLARGMGFRRPPAMPSTPLADVSPISGDSRRLAAGSNGFSSLPERATYGSREEFMPRDMRERFAAPAAYDQLSSREPGMNFSNRDSRNPNRPLAASPARGQTSGFTQNTSPERGWSEERLQEMSMATIREFYSARDEKEVALCIKDLNSQSFHPTMIALWVTDSFERKDMERHLLAKLLVNLARSRDGVLSQDQLVKGFESVLSTLEDVVNDAPKAAEFLGHIFAKIIVENVVTLNEIGRLIYDGGEEPGRLLETGLAADVLGSTLGVINTEKGETVLNEIRASSSLRLEDFRPPHSNKSSILEKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1F3</accession>
    <name>A0A0D2S1F3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_012G114600</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S1F3"/>
    <dbReference type="STRING" id="29730.A0A0D2S1F3"/>
    <dbReference type="Gramene" id="KJB76962">
        <property type="protein sequence ID" value="KJB76962"/>
        <property type="gene ID" value="B456_012G114600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779794"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEHEWIR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000067">
        <property type="entry name" value="calcium-dependent protein kinase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000050">
        <property type="entry name" value="Calcium-dependent protein kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="21">
        <location>
            <begin position="53"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="426"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="462"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB76962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="527" mass="59435" checksum="1F956E4977504308" modified="2015-04-29" version="1">MGNCCRSPAAVAREDVKSNFSGHDHGRKDSVSKQKPPITVLNGVPKENIEEKYLVDRELGRGEFGVTYLCIDRGTRELLACKSISKRKLRTAVDIEDVRREVAIMKHLPKNSSIVSLKEACEDDNAVHLVMELCEGGELFDRIVARGHYTERAAAAVTRTIVEVVQLCHKHGVIHRDLKPENFLFANKKENSPLKAIDFGLSIFFKPGERFSEIVGSPYYMAPEVLKRNYGQEIDIWSAGVILYILLCGVPPFWAESEQGVAQAILRGLIDFKRDPWPNISESAKSLVRQMLEPDPKLRLTAKQVLEHPWLQNAKKAPNVPLGDVVKSRLKQFSMMNRFKRKALRVIAEFLSVEEVEDIKVMFNKMDTDNDGIVSVEELKAGFKNYGSQLAEPEVQMLIEAVDANGKGTLDYGEFLAVSLHLQRMANDEHLRKAFSYFDKDGNGFIEPDELRDALMEDGADDCTNVANDIFQEVDTDKDGRISYDEFAAMMKTGTDWRKASRHYSRGRFNSLSIKLMKDGSLNLGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1Y6</accession>
    <name>A0A0D2S1Y6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein L30 ferredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G122600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S1Y6"/>
    <dbReference type="STRING" id="29730.A0A0D2S1Y6"/>
    <dbReference type="Gramene" id="KJB35651">
        <property type="protein sequence ID" value="KJB35651"/>
        <property type="gene ID" value="B456_006G122600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000002">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005998">
        <property type="entry name" value="Ribosomal_uL30_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01310">
        <property type="entry name" value="uL30_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="51"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="127"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB35651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="33093" checksum="F98512DD8D561B4E" modified="2015-04-29" version="1">MVARLTPDQKVACSIHVGLFSSPFYSFFLYKPLITLQQPHPKMGEEAKAVVPESLLKKNKRNEEWELAKKQELEVAKKKKVENRKLIYSRAKQYAKEYGAQEKELIQLKREARLKGGFYVDPEAKLLFIIRIRGINAMHPRTRKILQLLRLRQIFNGVFLKVNKATMNMLHLVEPYVTYGYPNLKSVRELIYKRGFGKLNKQRIALTDNAIVEQALGKFGIICVEDLIHEIMTVGPHFKEANNFLWPFKLKAPLGGLKKKRNHYVEGGDAGNRENYINELIRRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S4A8</accession>
    <name>A0A0D2S4A8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G161600</name>
        <name evidence="9" type="ORF">Gorai_001125</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S4A8"/>
    <dbReference type="STRING" id="29730.A0A0D2S4A8"/>
    <dbReference type="Gramene" id="KJB36486">
        <property type="protein sequence ID" value="KJB36486"/>
        <property type="gene ID" value="B456_006G161600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797957"/>
    <dbReference type="eggNOG" id="ENOG502QRB8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLGVDCF"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd17354">
        <property type="entry name" value="MFS_Mch1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF80">
        <property type="entry name" value="NODULIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="7">
        <location>
            <begin position="327"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB36486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0588006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="589" mass="64761" checksum="D72709C9FEAAD730" modified="2015-04-29" version="1">MVLTGKTGGGMKDFVFDVLSSRLFMVFATLIIMSVNGSGYMFGLYSNDIKSTLGYDQTTLNLLSFFKDLGGNLGILSGLIYEVVPPWVVLCMGSLMNFFGYFMIWVSVTGRIAKPHAWQMCLYMWIAANSQSFPNTGALVTCVKNFPENRGSVLGILKGFIGLSGAIMTQYYHAFYMDDTKALILLLAWLPTIVPLIFLRTIRIMKVVRMARELEIFYSFLYIALGLAGFIMVLIVLQNKVRFTRTEYVASAFVVVVLLLLPLVIVIKEEFSVWTGKKQASNNHSQVNVVTENPPAVPLRPAEATIWPLACIKTIFNPPERGEDYGILQAIFSIDMLILFIATACGTGGALTVIDNLGQLGKSLGYPKHSISTFISLVSIWNFLGRVLAGYLSEIALTNYNFPRPLMLTLVILFSCIGHLLIAFAVPNSLYFASVMTGFCLGAQLPLLCAIISELFGLKHYSTMYNVGSVSSPVGSYIFNVRVAGHLYDKEALKQMEALGLERKPGQDLTCNGATCYRLAFLIISVATLLGSIVSLILVCRTRTFYKGDIYKKFKEGVAPTGNGDLPLREMEDKATTAVPETKIAVSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S5H9</accession>
    <name>A0A0D2S5H9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G021100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S5H9"/>
    <dbReference type="STRING" id="29730.A0A0D2S5H9"/>
    <dbReference type="Gramene" id="KJB39594">
        <property type="protein sequence ID" value="KJB39594"/>
        <property type="gene ID" value="B456_007G021100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801892"/>
    <dbReference type="eggNOG" id="ENOG502S7AI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CASKLIP"/>
    <dbReference type="OrthoDB" id="690947at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267034" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB39594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="145" mass="15095" checksum="620AD511E9EE5163" modified="2015-04-29" version="1">MANLMIMAVLLVAVSTAATVTDAQATCAAKLVSCSRYILNTTIKPQDDCCNPIKEEVANDLSCLCNLYKDPKVFASLNISTAQALNVTRECGVTTDLTACNSNSTSTSSATSPPGGRSADQNGGADRISLTGVTIVFFFSISMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S5M3</accession>
    <name>A0A0D2S5M3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LRAT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G2480001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S5M3"/>
    <dbReference type="STRING" id="29730.A0A0D2S5M3"/>
    <dbReference type="Gramene" id="KJB26560">
        <property type="protein sequence ID" value="KJB26560"/>
        <property type="gene ID" value="B456_004G2480001"/>
    </dbReference>
    <dbReference type="OMA" id="CCQHDSK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.10">
        <property type="entry name" value="endopeptidase domain like (from Nostoc punctiforme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007053">
        <property type="entry name" value="LRAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137:SF1">
        <property type="entry name" value="LRAT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46137">
        <property type="entry name" value="OS05G0310600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04970">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51934">
        <property type="entry name" value="LRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LRAT" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB26560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="160" mass="17100" checksum="3EEBFEADFE892CE0" modified="2015-04-29" version="1" fragment="single">IYVGDDMVIHLRGAAKKLGELPACHKCGDKRVENGEIAKVCIDCFLDGATLQIFDYGVPLLEFIARKRGTCCQHDSKPPHEVISTATDLLERNGFGPYDMLTNNCEHFAVYCKTGSAASYQIAHHIEGVIATGPAGMLAGATVAVACGVSKGVRKTSSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S6M0</accession>
    <name>A0A0D2S6M0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="4">ARD'</shortName>
            <shortName evidence="4">Fe-ARD</shortName>
            <ecNumber evidence="4">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="4">ARD</shortName>
            <shortName evidence="4">Ni-ARD</shortName>
            <ecNumber evidence="4">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G242300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="4">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="4"/>
    <dbReference type="EC" id="1.13.11.53" evidence="4"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S6M0"/>
    <dbReference type="STRING" id="29730.A0A0D2S6M0"/>
    <dbReference type="Gramene" id="KJB37346">
        <property type="protein sequence ID" value="KJB37346"/>
        <property type="gene ID" value="B456_006G242300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800544"/>
    <dbReference type="eggNOG" id="KOG2107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNYIKLM"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000031">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF4">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB37346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="187" mass="22342" checksum="ABC185CDA63AB41F" modified="2015-04-29" version="1">MAIEAWFMDESKEDQRLPHRRNPNEPVSLEHLAELGVLYWHLNPKDYENDEELKKIREARGYNYMDLLDLCPEKVANYEEKLRNFYTEHIHADEEIRYCLEGSGYFDVRDKDDRWIRIWIKGGDLIILPAGIYHRFTLDTSNYVKLMRLFLGEPVWTAYNRPQEDHPARKEYIKSLTEKVGMPLAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7H9</accession>
    <name>A0A0D2S7H9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MACPF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G029400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7H9"/>
    <dbReference type="STRING" id="29730.A0A0D2S7H9"/>
    <dbReference type="Gramene" id="KJB79017">
        <property type="protein sequence ID" value="KJB79017"/>
        <property type="gene ID" value="B456_013G029400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784433"/>
    <dbReference type="eggNOG" id="ENOG502QRGU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMLHVKF"/>
    <dbReference type="OrthoDB" id="1366754at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009626">
        <property type="term" value="P:plant-type hypersensitive response"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of salicylic acid mediated signaling pathway"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="CAD1/NSL1-like"/>
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        <property type="entry name" value="MACPF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33199">
        <property type="entry name" value="MACPF DOMAIN-CONTAINING PROTEIN CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33199:SF4">
        <property type="entry name" value="OS02G0736300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01823">
        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MACPF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MACPF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MACPF" evidence="1">
        <location>
            <begin position="3"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="602" mass="67212" checksum="45C306761263F202" modified="2015-04-29" version="1">MRESEMSNNIGIVEKALSSLGRGFDLTMDFRLKYCKGKERLILLDETDKREIAVPGFGSIKDVPIDIKCDKGDRTRYQSDILDFNQMAEFFNKKCSIPGKIPSGRFNTMFGFQSGSWGKDAANTKCLGIDGYYIILFNLHIHRYPLLLSPHVLNDLPSTWDPYALARFIEKYGTHVIVGLSIGGHDVVLVRQDKSSNLEPSLLKKHLYDLGDQLFTGTCRFAPKTKDQKQKIPEAFNIFDQQSIALDGYPFINTKDGITVIGSKRGGDPEARSHCEWLPTVAGMPDAIHFNFIPITSLLKNAPGKGFLSHAINLYLRYKPPLGELRYFLDFQAQKIWAPIHNDLPLGPSTNRASSSPALHFNLMGPKLYVNTSQVTVGMRPVTGMRLYLEGMKCNRLAIHLQHLSTLPQTFENKMDDTQYWQASGDKADIRFFEAIHRKNFSHICTAPIKYNPEWRTGGKDAAFIVTGAQLHVKKHGSKSVLHLRLLFSKVSNCFLVRSSWAQAASGYSQRSSGLLSAISQSLTGNPVKEKEMAAVVVDSSVYPTGPPVPVQTPKLLKFVETSQLCKGPENSPGYWLVTGARLQLEKGKISLHVKFSLANVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBC1</accession>
    <name>A0A0D2SBC1_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G051900</name>
        <name evidence="3" type="ORF">Gorai_016098</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBC1"/>
    <dbReference type="STRING" id="29730.A0A0D2SBC1"/>
    <dbReference type="Gramene" id="KJB28503">
        <property type="protein sequence ID" value="KJB28503"/>
        <property type="gene ID" value="B456_005G051900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28505">
        <property type="protein sequence ID" value="KJB28505"/>
        <property type="gene ID" value="B456_005G051900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796746"/>
    <dbReference type="eggNOG" id="KOG4162">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QKMMKCI"/>
    <dbReference type="OrthoDB" id="29013at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043376">
        <property type="entry name" value="NPG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102:SF1">
        <property type="entry name" value="OS10G0471400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44102">
        <property type="entry name" value="PROTEIN NPG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="620"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0585318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="731" mass="81823" checksum="9DD33F8BC1B18746" modified="2015-04-29" version="1">MAVKDWINKRGFHIRGGFQKMMRCIWSGQQLRVDDTNASSESLATRDYSVSGYSSRAGEMVETKADSSNIEEAESSLRESGYLNYEEARALLGRLEYQKGNIEGALHVFEGIDVSAVTSKMKVTLSRRCEQNRRRSESEAAPAMSMHAISLLLEAIFLKAKSLQHLGRFGEAAQSCKIILETVESALPDGLPDFSTDCKLQEILNKAVELLPELWKLAGDPQEAILSYRRALLYYWNLDTGTKAKLEKEFAVLLLYSGAEASPLTLRAQMEGSFVPRNNVEEAILLLLILLRKFLLKRIGWDPSILDHLAFALSVSGELRALAHQVEELQPEIMERKEQYRTLALCYYGEGEEIIALNLLRNLLNSRDNPDCVLELLLASKICGENMNYIEEGTTWARKALVGLNGRCWQMVSKANCLLGVLLSAQSRMVSSDSQRNLQQSKTIEVLETAEKLMKESDPYIVFHICLENAEQRKLDVALHYAKQLLKLEAGSNVKGYVLLARILSAQKRFVDAETVINAALNQTGKWDQGELLRTKAKLQIAQGQLKNAVETYTHLLAILQVQHKSTGNGKKLLKTKGKWDRGLEMETWHDLANVYISLSQWQDAEVCLSKSKAISPFSATRWYSTGILNEARGLHQEALRSYKKALDVNPTHVPSLISTACILRQLGGQSMPIVRSFLMDALRLDRTNPAAWYNLGLLYKADVSASALEAAECFEAAAVLEESAPIEPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDL8</accession>
    <name>A0A0D2SDL8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="15" type="ORF">B456_013G134100</name>
        <name evidence="16" type="ORF">Gorai_002950</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Binds 1 heme group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0602781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDL8"/>
    <dbReference type="SMR" id="A0A0D2SDL8"/>
    <dbReference type="STRING" id="29730.A0A0D2SDL8"/>
    <dbReference type="Gramene" id="KJB81232">
        <property type="protein sequence ID" value="KJB81232"/>
        <property type="gene ID" value="B456_013G134100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784368"/>
    <dbReference type="eggNOG" id="KOG3453">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARCKACH"/>
    <dbReference type="OrthoDB" id="449280at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010336">
        <property type="term" value="P:gibberellic acid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000001">
        <property type="entry name" value="Cytochrome c iso-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002327">
        <property type="entry name" value="Cyt_c_1A/1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11961">
        <property type="entry name" value="CYTOCHROME C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00604">
        <property type="entry name" value="CYTCHRMECIAB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 11 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="14">
        <location>
            <begin position="10"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB81232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0602781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="113" mass="12274" checksum="534A39A1CA8CCE42" modified="2015-04-29" version="1">MASFAQAPRGDSKSGEKIFKTKCAQCHTIEKAAGHKQGPNLNGLFGRQSGTAPGYSYSAANKSMAVIWGENTLYDYLLNPKKYIPGTKMVFPGLKKPQERADLIAYLKESTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJ96</accession>
    <name>A0A0D2SJ96_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G437100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJ96"/>
    <dbReference type="STRING" id="29730.A0A0D2SJ96"/>
    <dbReference type="Gramene" id="KJB63193">
        <property type="protein sequence ID" value="KJB63193"/>
        <property type="gene ID" value="B456_009G437100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSETHCR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF683">
        <property type="entry name" value="OS05G0506800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251372" description="SGNH hydrolase-type esterase domain-containing protein" evidence="5">
        <location>
            <begin position="29"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB63193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44278" checksum="987338B495753F20" modified="2015-04-29" version="1">MATSSSCSSLKQHFLMFLVVTISSIINSQVNGCFTSIFSFGDSLTDTGNLLEISLSDSTNPPHSAFLPYGRTFFHHPTGRFCDGRLVIDFIAEALGFSFLPPFYGSKSGKWEKFQKGANFAVASATALNSSFLAEQGIHSVSTNISLGVEVNSFKHLLPSLCSSSSNCKELLRNSLIVMGEIGGNDYNHAFMQGKNIENIRQLVPLVVDIISSSINELIELGAMTFLVPGNFPIGCSPSLLTKFHGSERDQYDPLTGCLTWLNRFSQHHNELLRKELENIRSLHPQINIIYVDYYKAAVRFYHSPKQFGFKETLKACCGIGGLYNYDPLIFCGYPQLKQCCNDPSSYISWDGIHYTEAVNKWLAHTVFEELMSTIPSLGSLCPSSTVNKLRILYPMFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJY2</accession>
    <name>A0A0D2SJY2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G251400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJY2"/>
    <dbReference type="STRING" id="29730.A0A0D2SJY2"/>
    <dbReference type="Gramene" id="KJB83517">
        <property type="protein sequence ID" value="KJB83517"/>
        <property type="gene ID" value="B456_013G251400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNDSCYI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35468">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35468:SF1">
        <property type="entry name" value="MYOSIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="557" mass="64538" checksum="59BE54F3CA388577" modified="2015-04-29" version="1">MEKQSMGETITKRSKWQYPPPQPAPKILHLPPRPKRKPPLKPSKLPSLHNETKGKQLVNLFDQERCFKRGLIPLMLVNPMEESNEEMKREKVEEEEEEEEENNGGVVALVEEEKWKFQAEMLRAECNLLRIERDIVVKKMERSCVKMEKTLKSAVHTLVSGRNNICEENDVRMILEELINELLEKLEKLQKSTGVKDLEAKKWSNFDKQACFLRTRLDKFGEFSVEQIRAEEIREMAEASLSIKTSSESDESLISNRNNNILRRNMERLSKGVLFERMAEEYGLMASSGNSSKRIDYSDSSQSSTQRSDKVNIMNDSCYISMLIAHAYIRKVFTFVGSSSCKVNKWDMVAIVPRTIYSVPEKMSGEPRVCSGHCKAIVRRIVEQVRAETEQWSQMQDMLGQVRDEMEELQKCRDYWEDRALDSDYQIRSLKSAVKEWRQKAHSSEAKASELQARMFVLHEEIERLRNERERKTVRGRNTSPANQEARNETELMCDLKENRCANDDGCKAQPCTVTGLLPRRSPLRELGNMSALMKQHGEGILPLFCLRRDPETKCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SK25</accession>
    <name>A0A0D2SK25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G026100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SK25"/>
    <dbReference type="Gramene" id="KJB63463">
        <property type="protein sequence ID" value="KJB63463"/>
        <property type="gene ID" value="B456_010G026100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773544"/>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCYGRRY"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09440">
        <property type="entry name" value="LIM1_SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09441">
        <property type="entry name" value="LIM2_SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="9">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB63463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="190" mass="21146" checksum="E663125B8DE9D2D8" modified="2015-04-29" version="1">MAFAGTTQKCMACDKTVYLVDKLTADNRVYHKACFRCHHCKGTLKLGNYNSFEGVLYCRPHFDQLFKRTGSLEKSFEGTPKIAKPEKPVDGEKPIATKVSGMFGGTRDKCFGCKNTVYPTERVTVNGTPYHKSCFKCTHGGCVISPSNYIAHEGRLYCKHHHGQLIKEKGNLSQLEGDREKDGTEVAAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQG1</accession>
    <name>A0A0D2SQG1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E2F/DP family winged-helix DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G366600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the E2F/DP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQG1"/>
    <dbReference type="SMR" id="A0A0D2SQG1"/>
    <dbReference type="STRING" id="29730.A0A0D2SQG1"/>
    <dbReference type="Gramene" id="KJB46414">
        <property type="protein sequence ID" value="KJB46414"/>
        <property type="gene ID" value="B456_007G366600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB46415">
        <property type="protein sequence ID" value="KJB46415"/>
        <property type="gene ID" value="B456_007G366600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761700"/>
    <dbReference type="eggNOG" id="KOG2577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTHQICS"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14660">
        <property type="entry name" value="E2F_DD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000008">
        <property type="entry name" value="E2F transcription factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032198">
        <property type="entry name" value="E2F_CC-MB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF105">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2FA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16421">
        <property type="entry name" value="E2F_CC-MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="9">
        <location>
            <begin position="157"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="453"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="235"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB46414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="52910" checksum="54F42281D1D97999" modified="2015-04-29" version="1">MSGGAGASDGPTLPYQPSPTASTAPASTVPSVVPPIRRHLAFASTKPPFVHPDDYHRFSSSNSRGIVADQEVEAIVVRFPQLKRKSAADKNEVESSQWTSSPGVTSISNSPFQTPVSAKGGRIDNRSKTSKANKSMPQTPVSNAGCPSPLTPAGSCRYDSSLGLLTKKFVNLMKHAEDGILDLNKAAETLEVQKRRIYDITNVLEGIGLIEKKFKNRIQWKGVGASKPGETDGDVSVIQEEIENLSMEERRLDDQIREMQERLRDLSENENNQKLLFVTEEDIKGIPCFQNETLIAIKAPHGTTLEVPDPDEDVDYRQRRYRIILRSTMGPIDVYLVSQFEEKFEEMNGVEPPLRVPLASSSGSNENQVELVNTVSIQKEIELQAQQTHQICSDINATQESVGGMMRIVPSDIDNDADYWLLSDADVSITDMWKTDCVEWSGVDMLHSDFGMAEVGTPRPESPPSRMTEVPSSDFKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRV5</accession>
    <name>A0A0D2SRV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TNase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G040900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2SRV5"/>
    <dbReference type="Gramene" id="KJB33960">
        <property type="protein sequence ID" value="KJB33960"/>
        <property type="gene ID" value="B456_006G040900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TANRRNC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB33960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="316" mass="35341" checksum="FBE0238398E09AB8" modified="2015-04-29" version="1">MGLLATNKGKPMEGIMEQVRDGSTIRVYLLPDFQFVQVFVVGIQSPSMGRKAVVETVVETDLTSDDQNGNALAEPWAQLTSAQKLSVSAATVAEVSPDPFGREAKHFTEFRCLNRDVYIVLEGVDKFSNLIGSVYYPEGETAKDLALELVKNIVNAPRRGVQSSNDRFEVFYLDYRNQELVPYSQLRPIDASLSATPGLAQLYSLAFLKVPSLDDKFGTEAAQYWSEQTLGSSLQFKAVIEERDTSEGKIKGQGTDTCLVVTFFTEDPEDSINEAMLKDGLARLEKRMKWESNERKLMLNNFEECQEEAKTGWRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRX2</accession>
    <name>A0A0D2SRX2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G128800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRX2"/>
    <dbReference type="STRING" id="29730.A0A0D2SRX2"/>
    <dbReference type="Gramene" id="KJB66138">
        <property type="protein sequence ID" value="KJB66138"/>
        <property type="gene ID" value="B456_010G128800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2132">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061628">
        <property type="term" value="F:histone H3K27me3 reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046975">
        <property type="term" value="F:histone H3K36 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140684">
        <property type="term" value="F:histone H3K9me2/H3K9me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990110">
        <property type="term" value="P:callus formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080022">
        <property type="term" value="P:primary root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009787">
        <property type="term" value="P:regulation of abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900457">
        <property type="term" value="P:regulation of brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900140">
        <property type="term" value="P:regulation of seedling development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009741">
        <property type="term" value="P:response to brassinosteroid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010378">
        <property type="term" value="P:temperature compensation of the circadian clock"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056520">
        <property type="entry name" value="ARM_KDM8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24472">
        <property type="entry name" value="ARM_KDM8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="9">
        <location>
            <begin position="276"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB66138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="423" mass="47144" checksum="636CBEB069EAE1B8" modified="2015-04-29" version="1">MSSPAANIATAISTPTLDSESPALLQSITSHGGYAFTRMATLAAAGDQRAAEAACEMAWEQLHSGPWHSVLPVWRDAYSMACLHVAKFHFSNGEFRDALRSLDMGIIMGGPLLRKDLDSAIEVVLAAKSRHYHNGVADDDKEGHGEAGSRLLISPQEFDKSEVLQILPIRSLSSKIVGKRSALSLEAFLCEYFLSGSPVIITDCMAHWPARTRWNDMDYLRRIAGDRTVPVEVGKNYLCSEWKQELVTFSEFLERVQSTGCSSKAPTYLAQHQLFDQINDLRKDISIPDYCCAGGGELRSLNAWFGPAGTVTPLHHDPHHNILAQVVGKKYVRLYSATYSEELYPYSETMLYNSSQVDLDNIDEVEFPKSAIGGVLILEVQWCLRICKHLVFFLCLCCKILFGREVDFMYIKTFASKIYVQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSB7</accession>
    <name>A0A0D2SSB7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G051400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>gibberellin A12 + 2 2-oxoglutarate + 3 O2 + H(+) = gibberellin A9 + 2 succinate + 3 CO2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:60772"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58627"/>
            <dbReference type="ChEBI" id="CHEBI:73255"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60773"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the iron/ascorbate-dependent oxidoreductase family. GA20OX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSB7"/>
    <dbReference type="STRING" id="29730.A0A0D2SSB7"/>
    <dbReference type="Gramene" id="KJB34165">
        <property type="protein sequence ID" value="KJB34165"/>
        <property type="gene ID" value="B456_006G051400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798572"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQFIWPA"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045544">
        <property type="term" value="F:gibberellin 20-oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000003">
        <property type="entry name" value="Gibberellin 20 oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="274"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB34165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="430" mass="49029" checksum="9BA6B5A92B23770A" modified="2015-04-29" version="1">MLPLPSPSSFSITPYSFLCLNFISYPLFKYSQNHSYRYPSLLGLSIFTLHAMAIDCISNIASMTHHPKDEKKDEQKKLVFDASVLKFESQIPKEFIWPDDEKPSANAPELQVPLIDLGGFLSGDPVATMEASRFISEACQQHGFFLVVNHGVDAKLLADAHKYMDNFFLLPLRQKQRAQRKLGEHCGYASSFTGRFSTKLPWKETLSFRYSAENNSSKMVEDYLVNKMGNELRQLGRVYQDYCEAMSKLSLGIMELLAISLGVGRAHFREFFDKNDSIMRLNYYPPCQKPDLTLGTGPHCDPTSLTILHQDRVGGLQVFVDNEWHSISPNFEAFVVNIGDTFMALSNGRYKSCLHRAVVNSHKPRKSLAFFLCPEGDKVVTPPAELVSQNSPRVYPDFTWPMLLEFTQKHYRADMNTLQEFSNWVQQRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ST94</accession>
    <name>A0A0D2ST94_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_007G299500</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RBOH (TC 5.B.1.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ST94"/>
    <dbReference type="STRING" id="29730.A0A0D2ST94"/>
    <dbReference type="Gramene" id="KJB45301">
        <property type="protein sequence ID" value="KJB45301"/>
        <property type="gene ID" value="B456_007G299500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761044"/>
    <dbReference type="eggNOG" id="KOG0039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFWYTHQ"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016174">
        <property type="term" value="F:NAD(P)H oxidase H2O2-forming activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000049">
        <property type="entry name" value="Respiratory burst oxidase homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000019">
        <property type="entry name" value="Respiratory burst oxidase homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000007">
        <property type="entry name" value="Respiratory burst oxidase protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013623">
        <property type="entry name" value="NADPH_Ox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF64">
        <property type="entry name" value="RESPIRATORY BURST OXIDASE HOMOLOG PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08414">
        <property type="entry name" value="NADPH_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="481"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="705"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="576"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB45301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="884" mass="100857" checksum="6E17C9146B08CA0B" modified="2015-04-29" version="1">MEIHHSKHESWSDTESTSSSRVGYSGPLSGPILVNNANKKHSSKKSARFKDGDEYVEITLDIREDSVSVQNIKGGDPETAMLATKLEKRHSFGSQLSFKIRQVSQELKRMTSMKAAAPFNRADRNKSGAARALRGLKFMTKNVGTEGWSEIDSRFDELSVNGSLPKSLFGQCIGMNESKEFAEELFETLARRRGITSSAVNKAQLREFWEQITDQSFDARLQTFFDMVDKDADGRITEEEVKEIITLSASANKLSKIQECAEEYAALIMEELDKDNLGYIEIYNLETLLLQAPSQSTNLVTDSRILSRLLSEKLVPTKEKNPIKRWGRGLAYFSEDNWKRIWVLALWFSICAGLFTWKFIQYRHRAVFDVMGYCVTTAKGAAETTKFNMAIILLPVCRNTITWLRSRTKLGVVVPFDDNINFHKVVAWGIAVGVGLHAGAHLTCDFPRLLHATDDEYEPMEQFFGEERPNNYWWFVKGTEGWTGVTMVVLMAIAYTLAQPWFRRNRLNLPKSIKKLTGFNAFWYSHHLFIIVYALFIVHGYFLYLSKKWYKKTTWMYLAVPMLLYACERLIRAFRSGYKSVKILKVAVYPGNVLSLHMSKPQGFKYTSGQYIFVNCADVSPFQWHPFSITSAPGDDYLSIHIRTLGDWTSQLKALFSKVCQPPSVDQSGLLRADIGKGENKPRLPKLLIDGPYGAPAQDYKKYDVLLLVGLGIGATPLISIVKDVLNNIKQQNEIEEGVKNKRKPFATKRAYFYWVTREQGSFEWFRGVMNEVAEYDRDRMIELHNYCTSVYEEGDARSALITMLQSLQHAKSGVDIVSGTQVKTHFARPNWHKVFKHVAVNHTDKRVGVFYCGAPGLTGELRRLAQEFSRKTSTKFDFHKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SX74</accession>
    <name>A0A0D2SX74_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF5637 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G231300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SX74"/>
    <dbReference type="Gramene" id="KJB35945">
        <property type="protein sequence ID" value="KJB35945"/>
        <property type="gene ID" value="B456_006G231300"/>
    </dbReference>
    <dbReference type="OMA" id="WCKKLAF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252115" description="DUF5637 domain-containing protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB35945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB36400"/>
        <property type="gene ID" value="B456_006G157600"/>
    </dbReference>
    <dbReference type="OMA" id="ASATKYC"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB36400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="101" mass="10846" checksum="A40121DA015682B0" modified="2015-04-29" version="1">MHSKLVLIIKEVSENISMRNHQSSSVLVSATNNCSQVGLIRTNKGGISIGQKGSKGGSDPIILRLGIQGEVEGSTPKLQRFKIRTVETGQVVVKDEETSKS</sequence>
</entry>
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    <accession>A0A0D2T5N6</accession>
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            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
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    <organism evidence="2 3">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_008G235500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S79V">
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        <property type="component" value="Chromosome 8"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR38925:SF1">
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB51869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34539">
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    <proteinExistence type="predicted"/>
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        </location>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="23">Histone-lysine N-methyltransferase</fullName>
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        </lineage>
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    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Histone methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-lysyl-[histone] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10024"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:9846"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TG17"/>
    <dbReference type="STRING" id="29730.A0A0D2TG17"/>
    <dbReference type="Gramene" id="KJB74703">
        <property type="protein sequence ID" value="KJB74703"/>
        <property type="gene ID" value="B456_012G003100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780319"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15663">
        <property type="entry name" value="ePHD_ATX3_4_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PHD_ATX3_4_5_like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20143">
        <property type="entry name" value="PWWP_AtATX3-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd10518">
        <property type="entry name" value="SET_SETD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000058">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000454">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000464">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041955">
        <property type="entry name" value="ATX3/4/5_ePHD"/>
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    <dbReference type="InterPro" id="IPR042011">
        <property type="entry name" value="ATX3/4/5_PHD"/>
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    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
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    <dbReference type="InterPro" id="IPR025780">
        <property type="entry name" value="Hist-Lys_N-MeTrfase_ATX"/>
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    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
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    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
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    <dbReference type="InterPro" id="IPR000313">
        <property type="entry name" value="PWWP_dom"/>
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    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
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    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
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    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
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    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF132">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ATX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PHD_2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
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        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SAM_MT43_TRX_MLL"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PWWP" evidence="18">
        <location>
            <begin position="269"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="460"/>
            <end position="516"/>
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        <location>
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        <location>
            <begin position="709"/>
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            <begin position="942"/>
            <end position="1059"/>
        </location>
    </feature>
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        <location>
            <begin position="1068"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50016"/>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB74703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122900" checksum="42EBCF06190EC7BE" modified="2015-04-29" version="1">MIIKRNLKSQMPSLKRCKLGDSVGEDEDSSGTTRKKRKINYYYPLTLLGHVAAGIIPVSLHYIIASGELEKGFAASWNTEVSCSPDEVESKSKRSDSSKPKNRTVEIARPPLVRTSRGRVQVLPSRFNDSVIESWKKESKTSLHDHSFDEDEDDDDFECKKDKFSFKSSKNCKQNMKNQRNKENNGYKGRKYTTLCEEDDREAGYGRSSGIGKYSSFRSSLTSVHEQLVGEYEKNANGVLIVDLTTQGQASRENGEKEDGLYGPEDFYSGDIVWARPGKREPCWPAIVIDPMTQAPELVLRSCIAEAACVMFFGHSGNENQRDYAWVRRGMIFPFADFLDRFHEQPELAGCKPSDFQLAMEEALLAEEGFTEKLMDDINIAAGNPAYDESILRWGQEATGSNQDLGYCLPNQGLFGKCKDARFCESCGMTLPFKMGKKMKASTPGGQFLCKTCARLTKSKHYCGICKKIWNQSNSGSWVRCDGCKVWVHAECDKISSRHFKDLGATDYYCPACKAKFNFELSNPEKWQPKAKSKNNNSQLLLPNKVTIVCCGVEGIYYPSLHLVVCKCGSCGSEKQALSEWERHTGSRERNWRVSVKVKGSLLPLEQWMLQLAEYHANATSSAKPPKRPSLRERKQKLLAFLQEKYEPVRAKWTTERCAVCRWVEDCDYNKIIICNRCQIAVHQECYGARNVRDFTSWVCKACETPEVTRECCLCPVKGGALKPTDIETLWVHVTCAWFQPEVSFASDEKMEPALGILSIPSDSFVKICVICKQIHGSCTKCCKCSTYYHAMCASRAGYCMELHCLEKNGRQITKKVSYCAYHRAPNPDTVLIIQTPLGVFSAKKKSGSRLISSKRVKIEEVPTVETTDVEPFSAARCRVFKRSNNNRKRTEEEAVAHRLMRPCHHPLSTIQSLNAFRMVEEPTGFSSFRDRLYHLQRTENDRVCFGRSGIHGWGLFARRNIQEGEMVLEYRGEQVRRSIADLREARYRIEGKDCYLFKISEEVVVDATDKGNIARLINHSCMPNCYARIMSVGDDESRIVLIAKTNVSAGDELTYDYLFDPDEPEEFKVPCLCKAPNCRKFMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJL0</accession>
    <name>A0A0D2TJL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G047500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJL0"/>
    <dbReference type="STRING" id="29730.A0A0D2TJL0"/>
    <dbReference type="Gramene" id="KJB54751">
        <property type="protein sequence ID" value="KJB54751"/>
        <property type="gene ID" value="B456_009G047500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2056">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="20"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB54751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="602" mass="65215" checksum="414BF00221300689" modified="2015-04-29" version="1">MDFMKVFDQTVREIKREVNLKVLKVPEIEQKVLDATDNEPWGPHGTALAEIAQATKKFSEFQMVMNVLWTRLGETGKDWRYVYKALTVIEYLISHGSERAVDDIIEHTFQISSLTSFEYVEPSGKDMGINVRKKAETIVGLLSNKEKIQEARNKAAANRDKYVGLSSTGITYKSSASSYSSGGFNGGGDKYGGLSSRRESDSYRDSYKESDPYGEEKFDTDTYVKSHRGTACEIQGNSSKESRHHGSKDSKKKFSSELNDSNKYSQSTSTPSNNFDDDFDDFDPRGTSSSSKKNIHFLKPAAGSSNQVDPFVPNLIDDLFDGPAPVPMEKSAVSTDSTDVDLFADATFVSAPTKVTHESSPQAQQQVDLFASQPAITPAASPTVDIFAAGDPVVQPHIKGQVDLFASQPAITPAVSPTVDLFSTTDPVVQPAMAANVGPVNANIVDPFAAVPLNNFDGSDIFGSFTTHSDSALEEPKQNPMNDGNLNNMSTKSSQDSKAPQKKDAFQVKSGIWADSLSRGIIDLNISAPKKVSLADVGIVCGLSDVDEREKGPPTSFYMGRAMGTGSGLGKTGFASTPSTDEDGLFSSLGNHQQYQFGSFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQC7</accession>
    <name>A0A0D2TQC7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G166100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB77813">
        <property type="protein sequence ID" value="KJB77813"/>
        <property type="gene ID" value="B456_012G166100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB77813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10730" checksum="CEE85C3F8A655B96" modified="2015-04-29" version="1">MTVIGEVNLVTHHQARWRFLYRGHALPGGISILTVTDGFQWWHFQCRSEGDNMYCINGSEWSRFVQTRINAMITLYSKQDGEDFHRIRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TWC7</accession>
    <name>A0A0D2TWC7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G032700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TWC7"/>
    <dbReference type="STRING" id="29730.A0A0D2TWC7"/>
    <dbReference type="Gramene" id="KJB47590">
        <property type="protein sequence ID" value="KJB47590"/>
        <property type="gene ID" value="B456_008G032700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB47591">
        <property type="protein sequence ID" value="KJB47591"/>
        <property type="gene ID" value="B456_008G032700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB47592">
        <property type="protein sequence ID" value="KJB47592"/>
        <property type="gene ID" value="B456_008G032700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AHIAKFR"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16910">
        <property type="entry name" value="YEATS_TFIID14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1970:FF:000008">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="40"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB47590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="267" mass="30233" checksum="F099D74444264785" modified="2015-04-29" version="1">MVDTSLSKKKDPDQPEISLPTLKSQRTKMGKSEDSEKKKKIKDVEISVPIVYGNAAFWLGKKASEYQSHKWTVYVRGATNEDLSVVVKRAVFQLHSSFNNPTRVVESAPFELSESGWGEFEIAITLFFHNDVCEKPLNLYHHLKLYPEDESGPMSTKKPVVVESYDEVVFTEPSESFLARVQNHPAVTFPRLPAGVTLPPPVSIEDESKKKRGDTKDHPLSQWFLNFSEADELLQLAAARQQVQAHIAKLRRQISLTDGQNQQFKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TX26</accession>
    <name>A0A0D2TX26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ECERIFERUM 26-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G349800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TX26"/>
    <dbReference type="STRING" id="29730.A0A0D2TX26"/>
    <dbReference type="Gramene" id="KJB61284">
        <property type="protein sequence ID" value="KJB61284"/>
        <property type="gene ID" value="B456_009G349800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766182"/>
    <dbReference type="eggNOG" id="ENOG502QQYP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWAHIMG"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF115">
        <property type="entry name" value="PROTEIN ECERIFERUM 26-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="47783" checksum="82CD66009E55AE9B" modified="2015-04-29" version="1">MVPPQQDHDLVYNLRLSSVGPGCVTGSDVVHDLSGLDLTMKLHYLKAVYFFSSHAVEGLTIMNMKEAMFYLLNDYYITCGRIKRSESSGRPYIKCNDCGIRFVEGVCDETVDEWLETDDDSKRNLLVYHRAIGPELSFSPLVYLQVTQFKCGGISLGLSWAHILGDAFSVSNFINNWGQHMAMVNVNSSPALAPRSLTNTAKPEAPGEPLSAKQVNHVGDLWVLANNCKMETFSFNLTTQHLSNLQAKIGSVSAFDSICALLWRAIAKVREGFEPQIVTVCRKDPCHDDNNVLGNNQIIRTIKASFLVGESDLNKLATLIANDQGQVCDERNRIEAAVEKDNGSTDYIVYGSNLTFVNLENAGLYELELNGEKPKLAYYSIQGVGDEGAVLILPLPHGSAAENEGEPRYLVNLTLPEGQVFKLKAELKRASLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U026</accession>
    <name>A0A0D2U026_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase</fullName>
            <ecNumber evidence="3">2.8.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G413200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the sulfotransferase 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.8.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U026"/>
    <dbReference type="Gramene" id="KJB62349">
        <property type="protein sequence ID" value="KJB62349"/>
        <property type="gene ID" value="B456_009G413200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767942"/>
    <dbReference type="eggNOG" id="KOG1584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWQTHAS"/>
    <dbReference type="OrthoDB" id="205623at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11783">
        <property type="entry name" value="SULFOTRANSFERASE SULT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransferase" evidence="4">
        <location>
            <begin position="62"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB62349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="339" mass="39179" checksum="18162DD2525C8906" modified="2015-04-29" version="1">MVSKSHDVESSWDDEFKKLVQSFPKEKGWAGSNLYFYQGFWCPSLVLKAFISFQKHFQAFNSDIIVATFPKCGTTWLKALTFSTLYRNQFPWDENPLLTFGPHQLVRFFEYDLYLNNPFPDLRNVCAYQPRLFSTHAPYATLPTSIKDSGCKIVYICRNPMDMFISLWLFSAKLRDKNRESLSLDEAFDKFYHGISAHGPFFDHVLGYWKASQENPNKILFLNFEDLKEDMDSHLKILAMFLGVPFTDDEEKQGVVEKIAKICSFENLKELEVNMKGVHTSGVPHTHFFRKGEVGDWSNYLTPFMIECLEKLIQEKLNGSGLTFKLLSKTANNVASPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8Q0</accession>
    <name>A0A0D2U8Q0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_010G0415002</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8Q0"/>
    <dbReference type="STRING" id="29730.A0A0D2U8Q0"/>
    <dbReference type="Gramene" id="KJB64296">
        <property type="protein sequence ID" value="KJB64296"/>
        <property type="gene ID" value="B456_010G0415002"/>
    </dbReference>
    <dbReference type="OMA" id="PAFAHIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000416">
        <property type="entry name" value="Probable leucine-rich repeat receptor-like protein kinase At5g63930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF24">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252436" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="25"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="19">
        <location>
            <begin position="29"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="20">
        <location>
            <begin position="95"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB64296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="289" mass="31372" checksum="D4410E37BECC2C6B" modified="2015-04-29" version="1" fragment="single">MKSLTLLAPLLLCVTLLFSSLNVASDSAAEALAILKWKASLQSQNHSVLLSWNTSNDPYTKTSPCAWFGIHCNHADSVTKINLTGYGVKGTLHSFPFSSLPNLAELDLSINELYGIIPHNISQLSKLTYLDLSYNQFSGQIPPEISHLLHLQTLHLAGNQLNGSIPQELGQLKFLTDLALCSNKLNGCIPASLGKLSRLLSLILFDNSLSGPIPPELGNLRNLVEVYLDTNHLTGPIPSTFGNLKKLTVLQMFNNSLSGPIPSELGNMESLSEISLYHNNLSGLIPTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAN5</accession>
    <name>A0A0D2UAN5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_008G273200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAN5"/>
    <dbReference type="Gramene" id="KJB52700">
        <property type="protein sequence ID" value="KJB52700"/>
        <property type="gene ID" value="B456_008G273200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KIPGYCF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000020">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050481">
        <property type="entry name" value="UDP-glycosyltransf_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48048:SF30">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB52700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="465" mass="51272" checksum="7C5031B1104A99A1" modified="2015-04-29" version="1">MYTLCLLHFSLSPMEEAIVIYPAPMLTHLAPLVEFAKLLLTQHPSLSIHILIATLPSQPSSTVPSPVPPSIIFHYLPTVDLLPTSTDLDPLFFDVIRLRNPDVRRTLLTISNNYTLNAIIVDFFCTSAAFEVASDLNLPAYSFLPTALGAAACLLYLPTLCNKFTQSFQHLNVLLDIPGAPPIPSADMPPTTFKGNKLYDVFLDIATNLPRSTGIIVDTFEYLEPKSFKEINDGLCLPDYPTPPLYCIGPLIVNTTVDGDGVPQCIKWLDSQPSKSVVFLCFGSLGSFSVQQLKDIAVGLERSGERFLWIVRNPPLENQSLNIDTKIDPDLKSLLPPGFLERTKEKGLVVKSWAPQLAVLNHDSVGGFVTHCGWNSVLESVCAGVPMLAWPLYAEQRFNRVLMVEEMKIALPMVEKRVKELMGSKEGDSVRERALAMKHAAKVATSEGGSTRIALAKLVESWKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UE99</accession>
    <name>A0A0D2UE99_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_010G138400</name>
        <name evidence="7" type="ORF">Gorai_007774</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UE99"/>
    <dbReference type="STRING" id="29730.A0A0D2UE99"/>
    <dbReference type="Gramene" id="KJB66385">
        <property type="protein sequence ID" value="KJB66385"/>
        <property type="gene ID" value="B456_010G138400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66386">
        <property type="protein sequence ID" value="KJB66386"/>
        <property type="gene ID" value="B456_010G138400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774268"/>
    <dbReference type="eggNOG" id="KOG3999">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKICHLY"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000010">
        <property type="entry name" value="Checkpoint protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB66386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0597993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="319" mass="35633" checksum="114249981556C99A" modified="2015-04-29" version="1">MKFKAFLTEHGVNLLGRRFLPALDKMGKICHLFLTRDHAIFLHNLLNGDGVQCIAQFRKEALFDDYRISSQNEDRIAFAIDVSLLLRAVRSSVSICTEFGNGPSANRLQIKLVKKLPLNCTQPMPFLTFETKGYKSAVIQDVPISKPLSRAQVLELQTALELAQDIPQTLVRVPDLNQLQNFVERMKQVGDLLNVSISKYGDLHVQISTTLITLGAEFRKLLVIGEQAEAPSDDRNQSAQTRSERAISRGDAQRVQVSVKHFSRSLHCHLAKPDCTFYGIAPHGSCLTVIFQFFIPGTHQTDKSISLHCRLPVLDPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKM8</accession>
    <name>A0A0D2UKM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">starch synthase</fullName>
            <ecNumber evidence="6">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Soluble starch synthase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_011G013800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Amyloplast</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="6"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKM8"/>
    <dbReference type="STRING" id="29730.A0A0D2UKM8"/>
    <dbReference type="Gramene" id="KJB69269">
        <property type="protein sequence ID" value="KJB69269"/>
        <property type="gene ID" value="B456_011G013800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776089"/>
    <dbReference type="eggNOG" id="ENOG502QQTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018403at2759"/>
    <dbReference type="UniPathway" id="UPA00152"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009501">
        <property type="term" value="C:amyloplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (ADP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010021">
        <property type="term" value="P:amylopectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000165">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005085">
        <property type="entry name" value="CBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46083">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46083:SF5">
        <property type="entry name" value="STARCH SYNTHASE 3, CHLOROPLASTIC_AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16760">
        <property type="entry name" value="CBM53"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01066">
        <property type="entry name" value="CBM_25"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0035">Amyloplast</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Carbohydrate binding module family 25" evidence="17">
        <location>
            <begin position="268"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding module family 25" evidence="17">
        <location>
            <begin position="443"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate binding module family 25" evidence="17">
        <location>
            <begin position="605"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="364"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00079503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB69269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1153" mass="131428" checksum="10B5E6864EB071B8" modified="2015-04-29" version="1">MEASLQLQRFSSYGCFKIEPFLDSFPSVKTTQFTPWRSKCSVICLSHRVTASAADFSKRRQRRLSKGATPKGFTSKSRMSTQKRKQQKNNEQKEDSSIPKLSEFVEPNNREIELKVDEVENKEEKEDLSSIGKELDIRLSNHNVVNGNGNGMILGDVVGLEKKEISSENGTASIGLEKKEIGSENGTVSTLRDVVSEGKHIDDTKTGEIVTVEVESVEVDEKTVQDKSLQLKLEMETNLRKQEIEGLADENFLRGDKFFVYPQIIKPDGEIEVFFNRSLSNLKNEPDVLIMGSFNDWRWRSFTVRLNKTHLKGDWWSCLIRVPKEAYKMDFVFFNGQNVYENNDKNDFCITVEGGIDVFAFEDILVEEKRMELEKIAKEQAEKERQEEEQRRIGVEKAASEAERAQARIEIERRREILQQLMKKAAQSFDNIWFIEPKEFKGAEKVRLYYNKSSSHLTHANELWIHGGHNNWNDGLTIAEKLVKSEKEGGDWWYAEVVIPDGALVLDWVFANGPPKAATIYDNNNRQDFHAIVQKSIPEEQFWVEEEHRIFEKLQKDRKLREEAIHAKAEKTTQMKGEMKERTLKRFLLSQKNVVYTEPLDIHAGSMVTIFYNPANTVLNGKPEVWFRCSFNRWTHSMGPLPPQRMLPVDNGFHVKATVKVPLDAYMMDFVFSEREDGGIFDNNGGTDYHIRVVGGIVKEPPMHVVHIAVEMAPIAKVGGLGDIVTSLSRAVQDLNHNVNIVFPKYDCLKFEHVTDFHYQRCYSWGGTEIEVWFGKVEGLSVYFLDPQNGFFSTGCVYGRGNDAQRFGFFCHAALEFLHQSGFHPDIIHCHDWSSAPVAWLLKDHYMHYDGLSKSRVVFTIHNLEFGAHFIAKAMVYADKATTVSHTYSKEVAGNPAIAPHLHKFHGILNGIDLDIWDPFNDKFIPVSYNSENVIEGKQAAKKALQQRLGLKKSDLPLVGIISRLTHQKGIHLIKHAISRTLELNGQVVLLGSAPDPRIQNDFVNLANQLHSSHADRARLCLNYDEPLSHLIYAGSDFILVPSIFEPCGLTQLTAMRYGSIPVVRKTGGLYDTVFDVDNDKARAEAQGLEPNGFNFDGADGSGVDYALNRAITAWYGARDWFNSLCKTVMEQDWSWNRPALEYIELYHATKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULN0</accession>
    <name>A0A0D2ULN0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G149700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULN0"/>
    <dbReference type="Gramene" id="KJB68881">
        <property type="protein sequence ID" value="KJB68881"/>
        <property type="gene ID" value="B456_011G149700"/>
    </dbReference>
    <dbReference type="OMA" id="SHGCHPH"/>
    <dbReference type="OrthoDB" id="999601at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265648" evidence="2">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB68881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="10871" checksum="190FDEC3397135EC" modified="2015-04-29" version="1">MLYKKSVVHLILVLLLSFSLLLPPSSTTITHLTVIVKERSEVIHRNLGGGKPTPCPPHDPRCHGPSGRSPCRPHSHGCHPHVGLTPNHALGGGPGHASSGILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM43</accession>
    <name>A0A0D2UM43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP1-interacting protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G144900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2UM43"/>
    <dbReference type="Gramene" id="KJB56997">
        <property type="protein sequence ID" value="KJB56997"/>
        <property type="gene ID" value="B456_009G144900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57002">
        <property type="protein sequence ID" value="KJB57002"/>
        <property type="gene ID" value="B456_009G144900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57004">
        <property type="protein sequence ID" value="KJB57004"/>
        <property type="gene ID" value="B456_009G144900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57005">
        <property type="protein sequence ID" value="KJB57005"/>
        <property type="gene ID" value="B456_009G144900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768214"/>
    <dbReference type="eggNOG" id="ENOG502QQCY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAECEAF"/>
    <dbReference type="OrthoDB" id="767933at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008">
        <property type="entry name" value="COP1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008:SF15">
        <property type="entry name" value="GPI-ANCHORED ADHESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="225"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="354"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="660"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="881"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="669"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1035"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB57005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1428" mass="156995" checksum="9CC232E9F5811330" modified="2015-04-29" version="1">MKPDRLLDYAVFQLSPKRSRCELFVSSDGNLEKLASGLVKPFVTHLKVAEEQVALSLQSIKLEVEKCKNAETWFTKGTLERFVRFVSTPEVLELVNTLDAEMSQLEAARRIYSEGVGDQPSGALDGDDAGTMAAADATKKELLRAIDVRLIAVQQDLATAFTRSSAAGFNPDTVSELQQFADRFGAHCLNEACTKFLLLCQRRPELIGPCQSGINGQVVRASWGSDMSIDDPDEDHNGFHVNSRPHQPCQNKHQEQQLQPNTKQTQHHIDQSKLATSQQPNPSSTSQQSSHVENKEEEKKEEGVTESSPSQVSQPTRRLSVQDRINLFENKQKESSSSGGKPVAVGKSVELRRLSSDVSAAPAVAEKAVLRRWSGVSDMSIDLGNDKKDGNPDNSPLCTPSSSSVSQGKNNVFQGLSDDTEQKDEKGLSDNVNSGKVESTSGPNKAAGSGLKDPGELQSQVGNLLGKEEGVGLKGWINQKDQLGSQNGQYQSFTIKSEQVELGDQVASQQKVKGSLTGERRGLEVHSRVFPDKAVFVGVKNQLTQSQVGVFADEVGEATPEGELKNRAEAQNKEQSKRKVRLRAPGHSRTLSAQFEGGIGLKTKEAQYKSSEGDQYTTQPQLQWRSFTGEVEEVGTKDIASTEKQISKIEGSGVHKMKFKKQVAVGSEQSKKSQGRREEGGSIYANNKSVPGKKVLENEESLTTPMAPVDQTPRIRQTRGNQELNDELKMKANELEKLFAEHKRRVPGDQLSSARRSKPADEQIEQEGSSQYNKPVAVDVSPVQLPDKNSTSESVGSLSNIANFCTPPTKMVNNQDCADSLRQDFSSISFSGDSRGKFYEKYMRKRDAKLREEWSSKRAEKEAKLKAMQDILEQSRTEMKAKFSGTVDRQASISSARRQAEKGRSFNLRSQREQHPISSIQSEEDEDLPEYYGQDRSYNEASFLDGSSRSSNTKKLLPNRNASLSTPRTTAVTVPRSAAKVSNPTSGRRRAQSENPLVQSVPNFSDLRKENTKPSSGAGKVTSHFQARNYARSKSNNEEIALGKDEQSRRSQSHRKSFAGPVDVSDVPALNSDDIGLAPLKFDKEQMGQSFNDKSLKNEEAKPFLQKGNGFGPGAGVNIAKFKASETFATPNGEESDEPEFEADDSMDMANEDEEDELETMAVDDSADMENGRSRLSQESDKLDNSGLEICDSLRSPSQVDPASVAELPAPMLTTFHTAVSLQESPGESPVSWNSRMHNTYSYPQETSDIDASMDSPIGSPASWNSHPLAQTGVDAARMRKKWGSAQKPFLVANATHNQPRRDMTKGIKRLLKFGRKSRGTDSLVDWISATTSEGDDDTEDGRDPASRSSEDLRKSRMGFPQGHPSDDGYNESELFNDQVQSLRTSIPAVPANFRLREDHMSGSSIKAPRSFFSLSSFRSKGSDNKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNH1</accession>
    <name>A0A0D2UNH1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein BZR1 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein BRASSINAZOLE-RESISTANT 1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G036300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in brassinosteroid signaling. May function as transcriptional repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the BZR/LAT61 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNH1"/>
    <dbReference type="SMR" id="A0A0D2UNH1"/>
    <dbReference type="STRING" id="29730.A0A0D2UNH1"/>
    <dbReference type="Gramene" id="KJB69668">
        <property type="protein sequence ID" value="KJB69668"/>
        <property type="gene ID" value="B456_011G036300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69671">
        <property type="protein sequence ID" value="KJB69671"/>
        <property type="gene ID" value="B456_011G036300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777900"/>
    <dbReference type="eggNOG" id="ENOG502QQEG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWDAMVK"/>
    <dbReference type="OrthoDB" id="667790at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008540">
        <property type="entry name" value="BES1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033264">
        <property type="entry name" value="BZR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506">
        <property type="entry name" value="BES1/BZR1 HOMOLOG PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31506:SF2">
        <property type="entry name" value="BES1_BZR1 HOMOLOG PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05687">
        <property type="entry name" value="BES1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1070">Brassinosteroid signaling pathway</keyword>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BES1/BZR1 plant transcription factor N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB69671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="319" mass="34237" checksum="513E582E63CCC58B" modified="2015-04-29" version="1">MTSGTRMPTWKERENNKRRERRRRAIAAKIFAGLRMYGNYKLPKHCDNNEVLKALCNEAGWTVEEDGTTYRKGCKPVDRMDIMGGSASASPCSSYHPSPGSSSFPSPASSHYTANANGNADANSLIPWLKNLSSGSSSASSKLAHHLFIAGGSISAPVTPPLSSPTSRTPRTRSDWDEMNAGPTCTGKRFSYLPASTPPSPSRQVFPDPGWLSRLEIPQSGPTSPTFSLVSRNPFGFKDEALSGGGSRMWTPGQSGTCSPAFPAGVDQTSDVPMSDAIAAEFAFGSNMTGLVKPWEGEKIHEECVANDLELTLGNSKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR42</accession>
    <name>A0A0D2UR42_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="10" type="ORF">B456_011G089600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR42"/>
    <dbReference type="STRING" id="29730.A0A0D2UR42"/>
    <dbReference type="Gramene" id="KJB70716">
        <property type="protein sequence ID" value="KJB70716"/>
        <property type="gene ID" value="B456_011G089600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF54">
        <property type="entry name" value="MLO-LIKE PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB70716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="478" mass="55399" checksum="CBA1ACFC06348571" modified="2015-04-29" version="1">MSAEEESNSLEFTPTWVVAAVCFIIVLISIIAERGLHRLGKYLKHKKQDALFEALQKLKEELMLLGFISLLLTVFQGLVCEICIPAYFATSLLPCKRHSEEKTHEEYTSQAINNRRRLFSTDSGSDHCSREGKVPLLSREALHHLHIFIFVLAVVHVIFCVITMVLGGARIRQWKQWEELILKHGNEDTDHHHTFFARHAQGYWRRAAVVSWIMSFFKQFYDSVTKSDYLALREGFIRTQGHRNFDFHGYMIRTLEVDFKKIVGISWYLWLFVVVFLLLNVEGWHTYFWLSFLPVVLLLLVGTKLEHIITRLAQEVDVSEATQVKPSDTHFWFEKPGIVLHLIHFILFQNAFELAFFFWILCTYGFHSCIMERMSYIIPRLIMGVMVQVLCSYSTLPLYALVTLMGSQLKEGLFKEFVRSSLDKWFTERKGEASKHESTNTTQMDRMVKESYQSMPTGMSIAGETTLSITVQNSGPNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UX20</accession>
    <name>A0A0D2UX20_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ripening-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G320400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the kiwellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UX20"/>
    <dbReference type="STRING" id="29730.A0A0D2UX20"/>
    <dbReference type="Gramene" id="KJB60700">
        <property type="protein sequence ID" value="KJB60700"/>
        <property type="gene ID" value="B456_009G320400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECDSTMS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22270">
        <property type="entry name" value="DPBB_kiwellin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039271">
        <property type="entry name" value="Kiwellin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33191:SF77">
        <property type="entry name" value="RIPENING-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33191">
        <property type="entry name" value="RIPENING-RELATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24300">
        <property type="entry name" value="KWL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253142" description="Ripening-related protein 1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB60700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20446" checksum="25050A93C35E98AA" modified="2015-04-29" version="1">MKKQVICSTIFPLLCILLLFLSVEAQTCSPSGKIKGKTPPPGQCNQENDSDCCKDGKWYTTYKCSPPVSSQTKATLTLNSFEPDGDGGAPSECDNQYHSDDDPVVALSTGWYNNGKRCLNYINIHGNGESVRAKVVDECDSTMGCDSDHDYQPPCPNNIVDASKAVWKDLGVPESDWGVMDIYCSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXV0</accession>
    <name>A0A0D2UXV0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G250900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2UXV0"/>
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        <property type="gene ID" value="B456_011G250900"/>
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    <dbReference type="PANTHER" id="PTHR24128:SF60">
        <property type="entry name" value="ALPHA-LATROTOXIN-LHE1A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128">
        <property type="entry name" value="HOMEOBOX PROTEIN WARIAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
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    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="366"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="392"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <begin position="436"/>
            <end position="456"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="468"/>
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        </location>
    </feature>
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    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB73776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="502" mass="56198" checksum="30E1CF5DCF91DE3B" modified="2015-04-29" version="1">MKGAAQTGDINILYELILNDPYALQRIDDVPFFHTPLHVAASAGHIDFMMEMINLKPSFARKLNQAGFSPMHLALQNQKTQTVLRLLRFDEGLARVKGREGLTPLHDVVQNGNVDFLIKFLEVCPEAIEDMTVRDETVFHLAVKNDRFEAFQVLVGWLIRSRHKAASRWEKELLSWADIDGNTVLHVAAIRNRPQVVKVLLERLCGDHINAKNAEGLTALDIPSQYTLDEEKVDYKESIKDMISKAGGLSGSSSSLPKTSISSFHIAYLKGKVSVLQNFATIASRGKKGIPYEMRNTFLVVTVLIITATYTATLNPPKQPDTISNSQNFHLMYDASLGSTSTGPVPSPPPAEKEDLKNILDVSTMFWLYNTLTFWAATVLTAYLLPSRSICLFILITLSLFGTCYMLLVAVSIRTLELQYFFSLSTPGSVSYSRLSITNYCLATVLALVTLYRTSYYMLYRSVPKRRFFLLLQVVSLCIFAAILIPAILNSEFILEITKYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYM8</accession>
    <name>A0A0D2UYM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
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        </recommendedName>
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        <name evidence="6" type="ORF">B456_009G353800</name>
        <name evidence="7" type="ORF">Gorai_013352</name>
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    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYM8"/>
    <dbReference type="STRING" id="29730.A0A0D2UYM8"/>
    <dbReference type="Gramene" id="KJB61375">
        <property type="protein sequence ID" value="KJB61375"/>
        <property type="gene ID" value="B456_009G353800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQAHVCA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB61375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0596536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="253" mass="26993" checksum="0A3B17F46F51FF64" modified="2015-04-29" version="1">MAKEESPFKADVVKGKVCLITGGGSGIGFEISTQFGKHGASVAIMGRRKQVLDAAVSSLHSLGINAVGFEGDVRKQEDARRVVESTVKHFGCLDILVNAAAGNFLVSAEDLSPNGFRTVIDIDSVGTFTMCHEALKYLKKGGHGRNSSRGGSILNITATLHYTASWYQIHVAAAKAAVDSITRNLALEWGTDYDIRVNGIAPGPIGDTPGMSKLVPDEIKSKTREVMPLYKIGEKWDIAMAALYLVSDAGELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V231</accession>
    <name>A0A0D2V231_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TAF6 C-terminal HEAT repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G444300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V231"/>
    <dbReference type="STRING" id="29730.A0A0D2V231"/>
    <dbReference type="Gramene" id="KJB62940">
        <property type="protein sequence ID" value="KJB62940"/>
        <property type="gene ID" value="B456_009G444300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MMPINST"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="6">
        <location>
            <begin position="43"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB62940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="352" mass="39572" checksum="6208C09285C16D3E" modified="2015-04-29" version="1">MSVWIVDVIGTWNWYFAFHAAPSDGKMAEYKEDGLSVDVKLPVKPVLSRELQLYFDKIVDITMNKSVSVLFQQALLSLATDSGLHPLVPYFTYFIADEVVLKIFHTSLYMCVAKNFWLLHQLMPSIITCLVAKRLGNKFTDNHWGLRNFAAKLVASICKRVSYWTFHTNLHNEELVSEASLVAITSLLEKRSSSNFEDRFKDEEKPLLEPEIKRHEAWCVYGALLRVAGLCMYDRLKMFPNKRKASTGTLMQQQPPAKKIATESAIGMMPINSMQTDLQGAVSGFSTTIGGSNIGVSSMSRPLSNDNMLGREVGAQAWKEDTDPGNLLASLFELFGESMLSFTPKPELSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V390</accession>
    <name>A0A0D2V390_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G154800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant rapid alkalinization factor (RALF) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V390"/>
    <dbReference type="Gramene" id="KJB63415">
        <property type="protein sequence ID" value="KJB63415"/>
        <property type="gene ID" value="B456_010G154800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S8YN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDISINH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040008">
        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008801">
        <property type="entry name" value="RALF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136:SF89">
        <property type="entry name" value="PROTEIN RALF-LIKE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33136">
        <property type="entry name" value="RAPID ALKALINIZATION FACTOR-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05498">
        <property type="entry name" value="RALF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0372">Hormone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253199" evidence="7">
        <location>
            <begin position="21"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB63415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="13137" checksum="9B7132894DA61E28" modified="2015-04-29" version="1">MGSKVWHMFLLLALAMVAECTKFDEVNSGIHHRDNSRDSCIGEHCNIKDEIFMDSETNIRLLAARRYISYEALKRNNVPCSQQGRSYYECSTGKPVNPYTRGCTYATRCRRYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5C6</accession>
    <name>A0A0D2V5C6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G039900</name>
        <name evidence="11" type="ORF">Gorai_007097</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5C6"/>
    <dbReference type="Gramene" id="KJB64265">
        <property type="protein sequence ID" value="KJB64265"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64266">
        <property type="protein sequence ID" value="KJB64266"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64267">
        <property type="protein sequence ID" value="KJB64267"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64268">
        <property type="protein sequence ID" value="KJB64268"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64269">
        <property type="protein sequence ID" value="KJB64269"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64270">
        <property type="protein sequence ID" value="KJB64270"/>
        <property type="gene ID" value="B456_010G039900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2640">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIHRNTH"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02999">
        <property type="entry name" value="PDI_a_ERp44_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044606">
        <property type="entry name" value="APRL4/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46854">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE-LIKE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46854:SF1">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE-LIKE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395519" description="Thioredoxin domain-containing protein" evidence="8">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="51"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB64265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0597287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="321" mass="36212" checksum="0355FEB7BE1C2485" modified="2015-04-29" version="1">MGKEAWQTGTLILLLWWMMLPCAVSGPVRVPFCLKESISDAIFDFRDSYCPINSDFTESIDFVGVTEGDEVSLQKVLNMVHKNSHDYVAVLFYASWCPFSRSFRPTFSILSSSYPSIPHFAIEESAVRPSILSKYGVHGFPTLFLLNSTMHVRYLGNRTFESLGAFYCDVTGIRKKSLDKASINKIGHLSNHEKHNSTEPESCPFPWARSPENLLRQETYLALATTFVLLRSLYLLYPTLLVFAHFTWRLLIRNLKLGSLLEHPLAYLKRAIQLFNSLKEPCKRSNLQGAMNARAWASKSLATVSIGDANTSRAVPVTGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V636</accession>
    <name>A0A0D2V636_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G054400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V636"/>
    <dbReference type="STRING" id="29730.A0A0D2V636"/>
    <dbReference type="Gramene" id="KJB64570">
        <property type="protein sequence ID" value="KJB64570"/>
        <property type="gene ID" value="B456_010G054400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB64571">
        <property type="protein sequence ID" value="KJB64571"/>
        <property type="gene ID" value="B456_010G054400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773649"/>
    <dbReference type="eggNOG" id="ENOG502QTYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPRMEDI"/>
    <dbReference type="OrthoDB" id="1886636at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33977">
        <property type="entry name" value="ZINC ION BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="583"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB64570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="697" mass="80104" checksum="12BBC5E3DAA550C8" modified="2015-04-29" version="1">MKGHESKMARMEDILNLPVQDPPCAEFSAAHITWVKVEGGRQGGDDIALIPFSRVDDFVKGESSNAECPASFRIESRRKRSEGSISKPRVDGYLEYTLYWCSYGPEDYRDCESGLGDGSNFKPATGKGSRPGRRHMMRGCLCHFTVKRLYTRPLLALIIYNQRKHVDKTGSPCHGILDQDAVGTRAMYAPRISEELRQKVMSMLYVGISLDNIIQHHMEVVQGHGGPHNRDDFLTRNDVRNIERVIRNTSHELHIDDACSVKIWVQRHQKHVFYFQDASASEPFILGIQTDWQLQQMLRHGQNGSVASHSTFGSKKLKYPLSTLLVFDSSRNAIPVAWVITSSLTGQDIHKWVGSLAERLRTKDSRWRINAFLVDDPSFGFSAIRDAFQCRVLLCVWHVRRSWIRSLLKTCCNIDVQREMFKHLGWILYSSRSVPNAMDAVQEFMEVFVDQSAFMDYFKSQWSPHIESWVSCIRSLPVAGPEPHAAIESYHRRLKYKLFNDQYANFWPRIDWLIHTLTTEFHSLYWLDQYIVETGYFSNLRDESFSTNAWYQALHIPDIDVILDEQNLQVAKVISQTDRNLAYTIWNPGSEFSLCDCHWSNLGNLCKHVIKVAMMCKNRQVARPLLAAQIYRQTLLSLLHNPPDDPVVLDHAILCTTRLQQDIKGWEDLSNSGLLQQLPPELNSQMADNTLLFARSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCT5</accession>
    <name>A0A0D2VCT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G093400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VCT5"/>
    <dbReference type="STRING" id="29730.A0A0D2VCT5"/>
    <dbReference type="Gramene" id="KJB80354">
        <property type="protein sequence ID" value="KJB80354"/>
        <property type="gene ID" value="B456_013G093400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781817"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERETHIY"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="8"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB80354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="266" mass="30212" checksum="484F7D00FDFCA5FC" modified="2015-04-29" version="1">MSSSEKERETHIYLAKLAEQAERYEEMVESMKKVAKLDCELTVEERNLLSVGYKNVIGARRASWRIMSSIEQKEESKGNEENVKLIKGYRRKVEEELSNICTDILSIIDKHLIPSSSSGEATVFYYKMKGDYYRYVAEFKTDQERKEAAEQSLKGYEAASAAANTDLPSTHPIRLGLALNFSVFYYEIMNSPERACHLAKQAFDEAISELDTLSEESYKDSTLIMQLLRDNLTLWTSDLPEDGGEDTVKGDDTKSVAKSEAKAEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VDX3</accession>
    <name>A0A0D2VDX3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="4">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G223600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="4"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VDX3"/>
    <dbReference type="STRING" id="29730.A0A0D2VDX3"/>
    <dbReference type="Gramene" id="KJB68055">
        <property type="protein sequence ID" value="KJB68055"/>
        <property type="gene ID" value="B456_010G223600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68059">
        <property type="protein sequence ID" value="KJB68059"/>
        <property type="gene ID" value="B456_010G223600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0497">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042300">
        <property type="term" value="F:beta-amyrin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000044">
        <property type="entry name" value="Lupeol synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000011">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002365">
        <property type="entry name" value="Terpene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF48">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01074">
        <property type="entry name" value="TERPENE_SYNTHASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="6">
        <location>
            <begin position="135"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="5">
        <location>
            <begin position="449"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB68055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="797" mass="91795" checksum="675126F925FD1803" modified="2015-04-29" version="1">MGSEIFEVLEVVLDSGGRWNDSDKLITITYNSRKKMWRLKIGEGGNDPYLHSTNNFLGRQTWKFDPNAGTDEERAEVEEARLNFYKNRFNVQPSSDLLWQLQFLREKKMKQTIPQPKIEDGEEVTYEATTAAVKRSVHLFSALQSIHGHWPAENAGPMFYFPPLVMSLYITGHLNTIFSAEHRKEILRYIYCHQNEDGGWGLYIGGHSTMFCTALNYICMRLLGVGPDGGLNNACERGRKWILDRGGVTTISSWGKTWLSILGVYEWSGCHPMPPEFWLFPSYFPVHPAKMFCYCRLTYMPMSYLYGRKFVGPITPLISQLREELHIEPYNEIDWSTKRHLCAKEDLHYPHTWLQILLWDSLYIFSEPLLNCWPFNKLREKALKVTMDLIHYEDESSQYITVGCVEKPLCMLACWVEDPNGIPFKKHLSRVDDYVWVGEDGIKMQSFGSQVWDASLVLQALLASNLSNEIGPTLMKGHNFLKNSQVRDDPPGDFKKMFRHISKGSWTFSDRDHGWQVSDCTAESLKCCLSFSMMAPEMVGEKMEREHVYDAVNVLLSLQSKNGGFSAWEPAGGGFWWEWLNPVEFLEDLVKEYEYVECTSSSIQALVLFKKLYPGHREQEIENCIRKAAKYIEDIRYPDGSWYGNWGICFFYGTWFALLGLKAAGKNFENCLAIRKGVDFLLRTQREDGGWGESYLSCPKKVYTPIEEKESNLVSTAQAMMSLIVSGQAERDPTPLHRAAKLLINSQLPNGGFPQQGLAGVFMRNCMLHYAIYRNVFPLWALAEYRNHVWPSKYICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH74</accession>
    <name>A0A0D2VH74_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G183500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH74"/>
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        <property type="gene ID" value="B456_013G183500"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
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        <property type="entry name" value="HSF_DNA-bd"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
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        <property type="entry name" value="HEAT SHOCK FACTOR PROTEIN"/>
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        <property type="entry name" value="HSF_DNA-bind"/>
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        <property type="entry name" value="HSFDOMAIN"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="12">
        <location>
            <begin position="64"/>
            <end position="88"/>
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    <feature type="region of interest" description="Disordered" evidence="11">
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            <begin position="184"/>
            <end position="214"/>
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            <begin position="230"/>
            <end position="250"/>
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            <begin position="104"/>
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        <source>
            <dbReference type="RuleBase" id="RU004020"/>
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        <source>
            <dbReference type="SAM" id="Coils"/>
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    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS00434"/>
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    <sequence length="399" mass="44125" checksum="6200401334F5A625" modified="2015-04-29" version="1">METLHGSVPAACADTAANGNTVTPFLSKTFDVVDDPSTDSVVSWSSDNNSFVVWKVPEFARDLLPMYFKHNNFSSFVRQLNTYGFKKVDPDRWEFANEGFLRGKFGLQEEVEGLKRDKNVLMQELVRVRQQQQATDNQLQAYGQRVQMMEQRQQQMMSFLAKVMQTPGFLNQLLQQQNECNRQLTGANKKRRLHRQDEENLTGENGAVSPNGQTVKFQPLLNEHQMMEVNTSPRREHGAPPSSALHSSSSSSEIAEVILSEVSPASWQSYLQAESGVPDSSLSTAAAQLTTETSVHKSLKDAIFGSVPQMLGFVPDNIVGPESRNAEYLDPMSVVSNATMPTEADESCAGQDMEIMLDGSPKLPAINDTFWEHFLTGSPLTGDTDEINSSSLENGAYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ46</accession>
    <name>A0A0D2VJ46_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G066900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="gene ID" value="B456_011G066900"/>
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        <property type="component" value="Chromosome 11"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000003">
        <property type="entry name" value="ABC transporter C family member 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
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    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
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    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF108">
        <property type="entry name" value="ABC TRANSPORTER C FAMILY MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="752"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="764"/>
            <end position="785"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="797"/>
            <end position="814"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="861"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="259"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="484"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="732"/>
            <end position="884"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB70285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="105930" checksum="7273BD7FC4C74626" modified="2015-04-29" version="1">MGESNREDLISILVSICSAFISLVYFGTALWDIITRDEGLNDLEWLVYLVRGVIWMSVSVSLLVQTSKSIKIVISVWRKSFSLLVSAINIKLLFQTHNLPFFDLIQWPVNIMLLVFGFRNSISSSDTKCSEDHQVLYEPLFASKAKKAQVGIGRASFLSKLTFSWINTLFSLGHSKLLTLEDIPSLVDEDEASLAYERFAQAWESLVRGNSLSNSKNLVLRALAKVYFKENEVRNEDAIGFDGCSLSETVVLSCIGRRRHSTGEILNYIAVDAYRLGEFPWWLHSAWSLVLQLFMSIGILFYVVGLGALPGLVPLLICGVLNVPFANVLQKCQSQFMVAQDERLRLTSEVLNNMKIIKLQSWEEKFKNMIETRRENEFKWLEKEQISKAYGIVLFWISPTIISSVIFLGCAYLGSAALNASTIFTVLATLRSMGEPITMIPGALSVMMQVKVSTERINAFLLGDELNSEEPLISMQSSDKSVVIQAGNFSWDTELTVATLRDVNLEMKKGQKIAVCGPVGAGKSSILHVMLGEIPKISGTVYVSGSIAYVSQTSWIQSGTIRDNILYGKPMDEERYKRAIKSCAVDKDIDNFAHGDLTEIVKTIFTLLFQENDLVITQVMDGGSITQIGSYTELLMSGTACQELVNAHRDAMTVLDPLSNENKGKQEDTDTLQAEEYNKCYSTQQKSEGEISALGLPGVQLTEEEKKGTGDFGWRPFLDYIVVSKGYLFLSLAILSQFGFVIFQAAATYWLAIAIQIPEISSGLLIGVYTGISTLSAVFVHLRSIYSAHLGLKASKAFFYGFINSIFKAPMLFFDSTPVGRILTRASSDLSILDFDLPLSIGFVAAGSIELVAAIGVIAFVTWEVLIVAILVMIAVTYIQRIIRQEFSECTVITVAHTVPTVIDSDMVMVLSYGKLIEYDKPARLMGIESGFSKLVAEYWSSCRKGSSQAFSSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQI4</accession>
    <name>A0A0D2VQI4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MATH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G227700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQI4"/>
    <dbReference type="STRING" id="29730.A0A0D2VQI4"/>
    <dbReference type="Gramene" id="KJB73320">
        <property type="protein sequence ID" value="KJB73320"/>
        <property type="gene ID" value="B456_011G227700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADMNTFF"/>
    <dbReference type="OrthoDB" id="974022at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050804">
        <property type="entry name" value="MCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46236:SF35">
        <property type="entry name" value="MATH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46236">
        <property type="entry name" value="TRAF-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="3">
        <location>
            <begin position="31"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="336" mass="37815" checksum="F0F758A22780E836" modified="2015-04-29" version="1">MDVNGLITKVTWKIEVLSDVGSKSMGRNGQLTKVTWRIENFSTIQDKKLCSENFTVDGNKWQLIIYPGGANEAFLSIFLGVADSATLASGWTRYAHFGLLSSTNSIVKIPKHEAVELEQPAEEDMNTFFTILEYELSSSRIVYSKEEAKEALAKINEALNMTPVDLNDSGKISPLKQAFMILASFDGSSTTLTIEQKNELLGLEERLKELANRAAKAVQDKNQLTAKESIKRTMTRSLESSLIRYKEVETEVKQVDQILAARHEEVVEAQKKREKMLAERNGIYRSCKEMKMKLDALGKEWAVYEATARVGEEEEKSVEAEWGRIKDFISSINGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VQS7</accession>
    <name>A0A0D2VQS7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G233500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VQS7"/>
    <dbReference type="STRING" id="29730.A0A0D2VQS7"/>
    <dbReference type="Gramene" id="KJB73440">
        <property type="protein sequence ID" value="KJB73440"/>
        <property type="gene ID" value="B456_011G233500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778657"/>
    <dbReference type="eggNOG" id="ENOG502QTFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVIYVKC"/>
    <dbReference type="OrthoDB" id="1916878at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09008">
        <property type="entry name" value="MTAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21234:SF30">
        <property type="entry name" value="PHOSPHORYLASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21234">
        <property type="entry name" value="PURINE NUCLEOSIDE PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253792" description="Nucleoside phosphorylase domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside phosphorylase" evidence="2">
        <location>
            <begin position="47"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB73440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="340" mass="36977" checksum="428CB78002C7B0F5" modified="2015-04-29" version="1">MAATQLKPCLVLLLTFSVLAFASAISRNRIKSLNQIREVNRKGPYIGLITVIATEEDAFFASGSFKPDPKFPFIDLSGRRFRFGVVRGRKVVYVRCGEGMTNAVAATQQMADLFDIKGIIHFGIAGNTNNSMSIGDVTIPNQIAHTGLWEWFNTNGTLDSADVAQLEIGDYNVPKGNGTNLLGHIGYMEEEYYSVAGEPNVAESLLWANISLQWLQLASNLEGMKLEQCVNSSLCLTERPKLVVGLRASTSNIFLDNAAYRDFLFQKFGVSSADMESAGVAMTSLSNGYPVIVIRGLSDLAGNQEGDNAVRKFGGLAAVNSVKAVLGFIRNLPSSTRRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WAL9</accession>
    <name>A0A0D2WAL9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Pectate lyase</fullName>
            <ecNumber evidence="4 10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_N020100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="KB204389">
        <property type="protein sequence ID" value="KJB84350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WAL9"/>
    <dbReference type="STRING" id="29730.A0A0D2WAL9"/>
    <dbReference type="Gramene" id="KJB84350">
        <property type="protein sequence ID" value="KJB84350"/>
        <property type="gene ID" value="B456_N020100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYERHPE"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF208">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113007" description="Pectate lyase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="160"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB84350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="434" mass="48057" checksum="D9A8108F0E87EAB6" modified="2015-04-29" version="1">MGISSYSFFLFLFVVIIPTQESHIAEYDEYWTARELEAIENLDKAYHSNPEEVVRHYNDHFSRTMLEFYITKRVLAESKKGPCEVTNHVDSCWRCDPDWEKNRKKLANCAPGFARGTTGGKDGEFYVVTDPIDNATDPKPGTLRHAVTQTGPLWITFKGSMTIKLQQELIVTSDKTIDARGANVEICNGAGITIQFAKNIIIHGLQIHHIIPAKGGKIKDGENHHGLRGDSDGDGVSIFGATNVWLDHLALHHCADGLIDVVQGSTAVTVSNCHFTDHNDVMLFGASDSYSADKKMQVTVALNHFGKGLVERMPRCRFGFIHVVNNDYNHWFLYAIGGTSNPTIISQGNRYSAPGFGAKEVTCRGLLKPGQWKNWNWVSQGDHFENGAFFTPSGSPSASKQFGADKMMPFKPGQMVPELTKYAGPLSCTIGRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LXI0</accession>
    <name>A0A0D2LXI0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">anthranilate synthase</fullName>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G115500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterotetramer consisting of two non-identical subunits: a beta subunit and a large alpha subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LXI0"/>
    <dbReference type="STRING" id="29730.A0A0D2LXI0"/>
    <dbReference type="Gramene" id="KJB08952">
        <property type="protein sequence ID" value="KJB08952"/>
        <property type="gene ID" value="B456_001G115500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791884"/>
    <dbReference type="eggNOG" id="KOG1223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1865897at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.120.10:FF:000003">
        <property type="entry name" value="Anthranilate synthase component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="10">
        <location>
            <begin position="90"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="9">
        <location>
            <begin position="306"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="594" mass="66336" checksum="087D7A33EA363169" modified="2015-04-29" version="1">MAAIETLAFTPRLLPSNPLRFSSTVSVNLNPRFSGFRSKSISLIGSTSRVRTLRCTSLSSSPSIVDQSVKFREASKNGNLVPLYRCIFSDHLTPVIAYRCLVKEDDRDAPSFLFESVEPGLLASSVGRYSVVGAQPSIEIVAKENMVTIMNHEEGSKIEEIVDDPMTVPRRIMERWEPQRIDELPEVFCGGWVGYFSYDTVRYVEKKKLPFSSAPLDDRNLPDAHLGLYDDVIVFDHVEKKAFLIHWVRLDQYSSVDEAYNDGMKRLETLVSRVHDIDPPKLPAGSIKLYTRLFGPKLEISSMTSDAYTEAVLRAKEHILAGDIFQIVLSQRFERRTFADPFEIYRALRIVNPSPYMTYLQARGCILVASSPEILTRVKKGKITNRPLAGTIRRGKTPKEDLMLEKELLADEKQCAEHIMLVDLGRNDVGKVSKPGSVKVEKLMNIEQYSHVMHISSTVTGELLDDLTSWDALRAALPVGTVSGAPKVKAMELIDQLEVTRRGPYSGGFGGISFSGDMDIALALRTIVFPTATRYDTMYSYKDANKRREWVAHLQAGAGIVADSVPADEQRECENKAAALARAIDLAESSFVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M0Z1</accession>
    <name>A0A0D2M0Z1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G200700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M0Z1"/>
    <dbReference type="STRING" id="29730.A0A0D2M0Z1"/>
    <dbReference type="Gramene" id="KJB10432">
        <property type="protein sequence ID" value="KJB10432"/>
        <property type="gene ID" value="B456_001G200700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCEGCKQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45868:SF72">
        <property type="entry name" value="METAL TRANSPORT_DETOXIFICATION SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="74"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB10432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="237" mass="26758" checksum="266E02245965A8C2" modified="2015-04-29" version="1">MLTTGLGHGNFETYVLNVNINCDGCKQRVKKLLRKIEGVFSVHIDEELQVVTVTGKVDPTKLIKKLIKSGKHAEFRSPYENLNFIESDKNKNQMQYLRINGVNNSQIGYEVEDDFGNYVKHNIGNNSMTGTTDWNFIEETSMHRMEGDGDIFANNRHMVSMLDPAGFGRNVAGFVGLPPHEFGMFHDVPSSSSLATYDYNHLNLPSMTETSLQGYLLNNPSPNRNTCIQHRNKNSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MFM5</accession>
    <name>A0A0D2MFM5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G247300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MFM5"/>
    <dbReference type="Gramene" id="KJB16782">
        <property type="protein sequence ID" value="KJB16782"/>
        <property type="gene ID" value="B456_002G247300"/>
    </dbReference>
    <dbReference type="OMA" id="CHRRIVE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB16782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="91" mass="10733" checksum="D49BF0C019B0952D" modified="2015-04-29" version="1">MSSKQDYWQILQKRLKKPTVGKKKVRKLKLIKATMVKMREEMTQLVNMADNCHRRIVEAREEIRAQLVAADTRDALINEFICAWIDKNDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MFX0</accession>
    <name>A0A0D2MFX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G255000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB16885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_002G255000"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB16886"/>
        <property type="gene ID" value="B456_002G255000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB16887">
        <property type="protein sequence ID" value="KJB16887"/>
        <property type="gene ID" value="B456_002G255000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786477"/>
    <dbReference type="eggNOG" id="KOG0704">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000014">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044519">
        <property type="entry name" value="ARF_GAP_AGD6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47021">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47021:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN AGD6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB16887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="469" mass="51116" checksum="C5796C840C6503EC" modified="2015-04-29" version="1">MAASRRLRDLQSQPGNKTCVDCNQKNPQWASVSYGIFMCLECSGKHRGLGVHISFVRSVTMDSWSEIQIKKMESGGNERLNAFLAQYGIPKETDIVAKYNTNAASVYRDRIQALAEGRPWRDPPVVKENLNGGGSGGIRKPPLSSGGGGDRRSNFAGDNGGWDSWDNDDSFRSSSDIKRNQSASDFRGGSYHNGGRTGGAPVRSKSTEDMYTRSQLESSAANKESFFARKMAENESRPEGLPPSQGGKYVGFGSTPMPTQRINNSSQGDVFSVVSQGIGRLSLVAASAANVVQAGTKEFTSKVKEGGYDARVNETVGVVTAKTSEIGQKTWGMMKGVMAIASQKVEEYTKDGMNWKNDGNWQRNDSEKNGYYQEFKQENKGWNSTSGGQTSSGVNYNSYNSNSWDDWDTKDNRKEHTTKVTASHSNDGWAGWDDPKDDGYDSFYNGASDKNAVGRNGKSDAAWTGGGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MLY0</accession>
    <name>A0A0D2MLY0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Chaperone protein ClpB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent Clp protease ATP-binding subunit ClpB homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Casein lytic proteinase B1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Heat shock protein 101</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_003G100900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MLY0"/>
    <dbReference type="STRING" id="29730.A0A0D2MLY0"/>
    <dbReference type="Gramene" id="KJB19417">
        <property type="protein sequence ID" value="KJB19417"/>
        <property type="gene ID" value="B456_003G100900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRIMQDD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1780.10:FF:000003">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="17">
        <location>
            <begin position="3"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="406"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB19417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="888" mass="98668" checksum="7EAB802FCF937D13" modified="2015-04-29" version="1">MNPDKFTHKTNEALAGAHELATSNGHAQFTPLHLAVALISDSQGIFYQAISNSGGDRVAQSVDRVFNQALKKLPTQSPPPDQVPASSSLVKAIRRAQAAQKSRGDTHLAVDQLILGLLEDSQITDLLKEAGVTPAKVKSELEKLRGKEGKKVESASGDTTFQALKSYGTDLVEQAGKLDPVIGRDEEIRRVIRILSRRTKNNPVLIGEPGVGKTAVVEGLAQRIVRGDVPSNLADVRLVALDMGALIAGAKYRGEFEERLKAVLKEVEEAEGKVILFIDEIHLVLGAGRTEGSMDAANLFKPMLARGQLRCIGATTLEEYRKYVEKDAAFERRFQQVYVAEPSVPDTVSILRGLKEKYEGHHGVRIQDRALVIAAQLSSRYITGRHLPDKAIDLVDEACANVRVQLDSQPEEIDNLERKRMQLEVELHALEKEKDKASKARLVEEKERVDEIRRLKQKREELMLALQEAERRYDLARAADLRYGAIQEVESALAQIEGTADENIMLTETVGPEHIAEAVSRWTGIPVTRLGQNEKERLIVLAERLHQRVVGQNQAVDAVAEAVLRSRAGLGRPQQPTGSFLFLGPTGVGKTELAKSLAEQLFDDENLLIRIDMSEYMEQHSVARLIGAPPGYVGHEEGGQLTEAVRRRPYSVVLFDEVEKAHLSVFNTLLQVLDDGRLTDGQGRTVDFRNTVIIMTSNLGAEHILSGLSRKCTMQVARDRVMQEVRRHFKPELLNRLDEIVVFDPLSHDQLRKVARLQMKDVASRLAERGIALAVEDSALDYILAESYDPVYGARPIRRWLEKKVVTELSRMLVKEEIDENSTVYIDAPNGSELVYRVEKNGGLVNAETGQKADVLIRIPNGTRRSDAAQAVKKMKIEEIDDEDEMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MQU5</accession>
    <name>A0A0D2MQU5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G052500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB21212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2MQU5"/>
    <dbReference type="Gramene" id="KJB21212">
        <property type="protein sequence ID" value="KJB21212"/>
        <property type="gene ID" value="B456_003G052500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDIFIMF"/>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="AtLOH3-like"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 2-RELATED ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697:SF230">
        <property type="entry name" value="ZINC FINGER, MYM DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
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    </dbReference>
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        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="37"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="55871" checksum="C45F0B4A53648812" modified="2015-04-29" version="1">MYKYPVNMCEEIRRAYIKNIHLLKMHNPSNHFGSTTFTHSGFSNWKKVHNGCNFVFLTRVGKDLNSLHNNSQHVDLMNQSQYIEVSLDRQTTQQITANRLCLKTRYAFGGYDESSGSKYRGNFLEFLSLLSSYDEKVKDVLKSAPQNASYTSSTIQEEILQIYTSRVCNVIHKEIGDKKLCIIVDEARDDEEQAAEITRLVSINELATRIGMNQIGTLQHLGETRWSSHLNSITILLTMYNATSTILENLKNIAPNHSQRGDAHNTYNRLRSFEFIFILHMIKEVLGVTDNLCQALQRRFQDILNVLSLVSTTKDLIQKLRDDGWDELLKNVIYFCETWELDFPYMNAQYIMDRSHNKKEDVTLKHYELDVCKHPDLRKISTLSELCRSLVESGKSVMYPLFDRLICPLLTFLVSTASAKRVFSAMKIVKTRFCSKMEDDFLRSYLVVYTEKEIPENFNVNKIINGFSEIKDWKVQFKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MRJ0</accession>
    <name>A0A0D2MRJ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G000700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MRJ0"/>
    <dbReference type="STRING" id="29730.A0A0D2MRJ0"/>
    <dbReference type="Gramene" id="KJB21543">
        <property type="protein sequence ID" value="KJB21543"/>
        <property type="gene ID" value="B456_004G000700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21544">
        <property type="protein sequence ID" value="KJB21544"/>
        <property type="gene ID" value="B456_004G000700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21545">
        <property type="protein sequence ID" value="KJB21545"/>
        <property type="gene ID" value="B456_004G000700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21547">
        <property type="protein sequence ID" value="KJB21547"/>
        <property type="gene ID" value="B456_004G000700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21551">
        <property type="protein sequence ID" value="KJB21551"/>
        <property type="gene ID" value="B456_004G000700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789932"/>
    <dbReference type="eggNOG" id="KOG4561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MPVYYSH"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="7">
        <location>
            <begin position="49"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB21547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="259" mass="29960" checksum="FC19D545E27DBEF9" modified="2015-04-29" version="1">MADLPSFSTKEFYWLASCFWGIITCKLVYDITGFISPFCFKGYGKLSDKEKMEWNNRGFSTFHALIAAWASLYLLLFSDLFDEDSSNDLIVNRSSVISNMFLGFSIGYFLSDLAMVFWHFPALGGLEYVLHHGLSMFSISLSLMSSQGQIYILMVLFSESTTPFVNIRWYLDVAGWKSSTIYIYNGIALFFGWLIARIFLFIYFFAHMFNHFDEVKKIFPLGFYSLLTVPPVLGLMNVVWFWKIVKGLIKTISKARHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N2I9</accession>
    <name>A0A0D2N2I9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G175900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N2I9"/>
    <dbReference type="STRING" id="29730.A0A0D2N2I9"/>
    <dbReference type="Gramene" id="KJB06483">
        <property type="protein sequence ID" value="KJB06483"/>
        <property type="gene ID" value="B456_001G175900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0408">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAVDQGM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003698">
        <property type="entry name" value="PRK05309.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB06483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13052" checksum="7AA6E1EA02CA22B6" modified="2015-04-29" version="1">MLEPPLSCQLSITRKSALSFNNTIVTVTDVWGRVVSWSSASTCGFKGTRKGTPLAAQTAVGNAIRAVVDQCMQRAEVMIKGPGLERDAALRAIRRSGILLSFVRDVTPMPHNGYRHPKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N6G1</accession>
    <name>A0A0D2N6G1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protease Do-like PDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G070400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N6G1"/>
    <dbReference type="STRING" id="29730.A0A0D2N6G1"/>
    <dbReference type="Gramene" id="KJB08193">
        <property type="protein sequence ID" value="KJB08193"/>
        <property type="gene ID" value="B456_001G070400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CVRIRRV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000012">
        <property type="entry name" value="protease Do-like 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.10:FF:000131">
        <property type="entry name" value="Protease Do-like 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041517">
        <property type="entry name" value="DEGP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046449">
        <property type="entry name" value="DEGP_PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45980:SF18">
        <property type="entry name" value="PROTEASE DO-LIKE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17815">
        <property type="entry name" value="PDZ_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Protease Do-like PDZ" evidence="6">
        <location>
            <begin position="431"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="584" mass="63731" checksum="F10C04E5060BBA6D" modified="2015-04-29" version="1">MGDTKRKRGRKPKNPTPSQPLQSPPSSPSDDVFSLSNIEIIPSTSSAVEITTTASRPRGRPKKLPKLPDNPDPLPPPPILSPCRHVSNGTAIGVGGGSGGGELAVDPIGARVVPAMDAVVKVFCVHTEPNFSLPWQRKRQYSSSSSGFVISGRRVLTNAHSVEHYTQVKVKKRGSDTKYLATVLSIGTECDIAMLTVNDDEFWEGVSPVEFGELPALQDAVTVVGYPIGGDTISVTSGVVSRIEILSYVHGSTELLGLQIDAAINSGNSGGPAFNDKGNCVGIAFQSLRQDEAENIGYVIPTPVIQHFIQDYEKNEAYTGFPILGIEWQKMENPDLRKAMGMKPEQKGVRIRRVDPTTPESGVLKSSDIVLSFDGVDIANDGTVPFRHGERIGFSYLVSQKYTGDSSAIEVLRNSEILNFNIKLTSSRRVIPAHNRGKPPSYYIIAGFVFTTVSVPYLRSEYGDNYEYEAPMNLLDKLYHATLQSPDEQLVVVSQVLVSDINIGYEDIVNTQVLALNGKPVANLWRLAEMVENCDDEFLKFDLEYEQIVVLRTMTAKAATPDILATHCIPSAMSADLKALRPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NCZ0</accession>
    <name>A0A0D2NCZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dCTP pyrophosphatase 1</fullName>
            <ecNumber evidence="1">3.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G228800</name>
        <name evidence="4" type="ORF">Gorai_021709</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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                <person name="Conover J.L."/>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
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                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Reddy U.K."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Byers R."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NI57"/>
    <dbReference type="STRING" id="29730.A0A0D2NI57"/>
    <dbReference type="Gramene" id="KJB32642">
        <property type="protein sequence ID" value="KJB32642"/>
        <property type="gene ID" value="B456_005G253000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795394"/>
    <dbReference type="eggNOG" id="KOG4306">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NENCGES"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08619">
        <property type="entry name" value="PI-PLCXDc_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="51"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="318" mass="36232" checksum="3E4454A00913E12C" modified="2015-04-29" version="1">MGSLFSKQFERRKNIKAEKKTLCDLNENCGESYPGSDYRPADRKNWMAGLGVDKVYINKIVWPGTHDSATNKIGIPFITRPFAQCQSLSVYQQLVKGTRVLDIRVNENRRVCHGVLTTYGIDVVIGDIKKFLSETQSEVIILEIRTEFGHQDPPEFEKYLEEQLGEYLIHQDEHVFGKTIAELLPKRIICVWKPSKSPRPQSGSPFWNAGHLKDNWIDTDLPSTKFDSNLKHLSEQPPASSRKFFYRVENTVTPQPDNPIVCVKPVTNRIHGYARLFITQCFTKGCADRLQIFSTDFIDEDFVDACVGLTQARVEGAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2V3</accession>
    <name>A0A0D2P2V3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G042800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P2V3"/>
    <dbReference type="Gramene" id="KJB40022">
        <property type="protein sequence ID" value="KJB40022"/>
        <property type="gene ID" value="B456_007G042800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009543">
        <property type="term" value="C:chloroplast thylakoid lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006514">
        <property type="entry name" value="IRX15/GXM/AGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037734">
        <property type="entry name" value="Thylakoid_lumenal_17.9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01627">
        <property type="entry name" value="A_thal_3515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36783">
        <property type="entry name" value="THYLAKOID LUMENAL 17.9 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36783:SF2">
        <property type="entry name" value="THYLAKOID LUMENAL 17.9 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21729">
        <property type="entry name" value="IRX15_IRX15L_GXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB40022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="468" mass="51148" checksum="EDD3A3F5C0ABAC13" modified="2015-04-29" version="1">MTNTLIAQLHLVPPFPSPSKQSSISQPQIKIPNNPNPKPKPIVFSKFLSLALTLTLNSPLPSLAIPSLTSQSSPQAPLTTTPFTQSKFLQLGLEDGKIRPCPSTNPGCVSTNAKSSSFAFPWVVPETSKENAVQELQEAILKTQKNAKIEVVEDTPNGKYIQAEVDGGFGPDVMEFLVKGDVVTYRSMAMKVTYIYPFTTAIGDSKGQLERLKKIVDQLGCNFLSNATPVVDSESGGRHEPTPAATAANATLLTPKEFMVLSKLVTRKAPCNLLVFGLQSQYYNLSSINAGGITVFLEDDPLKISEIKADFNGTRIYNVKYQIAAKKAYNLLKHARKNPACSPTINLLNQSSCKLALRNLPEDVYKLKWDVVVVDGPIGDTPEAPGRMPTIYTAGMLARTDGIGKKTTTDVVVHDVHRTIEKWFSWEFFCEQNLVSARGKLWVFRIPVHQSNSTSFCSSETVVNGGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P3J4</accession>
    <name>A0A0D2P3J4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_007G060700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P3J4"/>
    <dbReference type="SMR" id="A0A0D2P3J4"/>
    <dbReference type="STRING" id="29730.A0A0D2P3J4"/>
    <dbReference type="Gramene" id="KJB40307">
        <property type="protein sequence ID" value="KJB40307"/>
        <property type="gene ID" value="B456_007G060700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40308">
        <property type="protein sequence ID" value="KJB40308"/>
        <property type="gene ID" value="B456_007G060700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40309">
        <property type="protein sequence ID" value="KJB40309"/>
        <property type="gene ID" value="B456_007G060700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802276"/>
    <dbReference type="eggNOG" id="KOG0094">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="XIDIKLE"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00006270"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
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            <dbReference type="ARBA" id="ARBA00022741"/>
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            <dbReference type="ARBA" id="ARBA00022892"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037794"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00053550"/>
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    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="KJB40307.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <sequence length="208" mass="23091" checksum="8B8C70FF95775337" modified="2015-04-29" version="1">MATVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVIAYDVANRQSFLNTSKWIEEVRTERGTDVIIVLVGNKTDLVDKRQVSIEEGDSKARELGVMFIETSAKAGFNIKPLFRKIAAALPGMGSLSSTKQDDMVDVNLKSSGNSYQNPDQQGGGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PGV0</accession>
    <name>A0A0D2PGV0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="13">GATA-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="14" type="ORF">B456_004G230100</name>
        <name evidence="15" type="ORF">Gorai_015382</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PGV0"/>
    <dbReference type="Gramene" id="KJB26178">
        <property type="protein sequence ID" value="KJB26178"/>
        <property type="gene ID" value="B456_004G230100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLSGSCE"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:sequence-specific DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GATA_TF"/>
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    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
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    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF134">
        <property type="entry name" value="GATA TYPE ZINC FINGER TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="13">
        <location>
            <begin position="258"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB26178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0584577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="346" mass="37563" checksum="7EBF290404A79B3D" modified="2015-04-29" version="1">MNNSWFNKCFDGFGVNDGLFDDVVKYLDFPLEDVEGTDDDGASGEGVVKDFHLPLGDVEDKSYVGGGGDDGGEDWDCNFQNLEPPPANVLAGLSSGFCGDFFSDTLENKFPVSCDESSELNQLSGITKASSSRSTTTLNGESVDVKGSTWFQTSSPVSVLETSSACSSAKPAPINPKLSFLVKRDRSKRRRASTFNLQFTLPSISSTGSTSLVGSESESESHLTEKSAKKRQKKKNLTWLSGSCEIDKSSSEEAAVVRKCTHCEVTKTPQWREGPKGPKTLCNACGVRYRSGRLFPEYRPAASPTFVPSLHSNSHKKVIEMRKQCQAAEVGNTIYGVNSTRNRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PHG5</accession>
    <name>A0A0D2PHG5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G308000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PHG5"/>
    <dbReference type="STRING" id="29730.A0A0D2PHG5"/>
    <dbReference type="Gramene" id="KJB45472">
        <property type="protein sequence ID" value="KJB45472"/>
        <property type="gene ID" value="B456_007G308000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DINRGRY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB45472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="262" mass="30317" checksum="82969242060E7CF3" modified="2015-04-29" version="1">MTLISSNKSIVVRQVFAEDLDNTEFPGMIFKPNKQVIDKGDPIINYNYMKSNVDALQIIQLGLSLSDARGNLPDFDSPFSYFWEFNFREFDINRGRYASDSIELLIRQGIDFEKNKEKGIDSKYFAKKFWDYGLLFNCYGLKSITWITVHSTYDFGFMQKILTQSPMPLHLHSFVHQLAYFFGYNIFDLEHTFKLLGLLGGLERIAQTLNVAHITRSSHQAGLDSLLTLQCFMKLKSENVFESKWNKTNQMLLPPLVLYGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PKM3</accession>
    <name>A0A0D2PKM3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_007G378900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PKM3"/>
    <dbReference type="STRING" id="29730.A0A0D2PKM3"/>
    <dbReference type="Gramene" id="KJB46627">
        <property type="protein sequence ID" value="KJB46627"/>
        <property type="gene ID" value="B456_007G378900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761859"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSNSPDQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000225">
        <property type="entry name" value="cold-responsive protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000044">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052059">
        <property type="entry name" value="CR_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47973">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="46"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB46627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="370" mass="41269" checksum="FE24122E5C86340E" modified="2015-04-29" version="1">MSCKCFGSFDWFKGSNSPDQTQAQEFTNENVKLFTYNSLRSATSDFHPSNRIGAGGFGVVYRGVLRDGTQVAIKKLSAESKQGSNEFLTEIDMISNIRHTNLVELIGCCVEDSHRALVYEYLENNSLASVLLGSRRKHIALDWPTRAAICLGTASAVAFLHYEAVPHIVHRDIKASNILLDGNFHPKIGDFGLAKLFPDNVTHVSTRVAGTFGYLAPEYALLGQLTKKADVYSFGVLLLEIVSGKSSSKAAFGVEFMLLLEWTWKLKEEDRLLDIVDPELSQYPEEEVLRFIKVALFCTQAAANQRPTMKQVVEMLSKEVNLTEKLLSEPGVYKGQNPRHWGVNKDLQAFDPSSSSRIFSSHIITQMLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PWV8</accession>
    <name>A0A0D2PWV8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">diphosphoinositol-polyphosphate diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G096500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + H2O = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:79699"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:79700"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:56312"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:140372"/>
            <dbReference type="ChEBI" id="CHEBI:140374"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:56313"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22384"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22385"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>6-diphospho-1D-myo-inositol pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:79703"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:230534"/>
            <dbReference type="EC" id="3.6.1.52"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:79704"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Atypical dual-specificity phosphatase Siw14-like subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.52" evidence="1"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PWV8"/>
    <dbReference type="STRING" id="29730.A0A0D2PWV8"/>
    <dbReference type="Gramene" id="KJB08661">
        <property type="protein sequence ID" value="KJB08661"/>
        <property type="gene ID" value="B456_001G096500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789975"/>
    <dbReference type="eggNOG" id="KOG1572">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWNPISE"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052847">
        <property type="term" value="F:inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052845">
        <property type="term" value="F:inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14528">
        <property type="entry name" value="PFA-DSP_Siw14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000024">
        <property type="entry name" value="probable tyrosine-protein phosphatase At1g05000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020428">
        <property type="entry name" value="PFA-DSPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF48">
        <property type="entry name" value="INOSITOL PHOSPHATASE SIW14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01911">
        <property type="entry name" value="PFDSPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="9">
        <location>
            <begin position="56"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB08661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="213" mass="24429" checksum="24928AA5A3A814B8" modified="2015-04-29" version="1">MKDDTATTTELIQNQHQKGNQEMCRATEVVSTVDRVVDMSSPVMSQDELNLIPPLNFAMVDNGIFRSGFPDSANFSFLQTLRLRSIIYLCPEPYSEANNEFLKSNGIKLFQFGIEGYKEPFVNIPQDTIREALKTLLDVRNHPVLIHCKRGKHRTGCLVGCLRKLQRWCLSSIFDEYQRFAAAKARVSDQRFMELFDVSSLKHLPMSFSCLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PXQ0</accession>
    <name>A0A0D2PXQ0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G119900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PXQ0"/>
    <dbReference type="Gramene" id="KJB09026">
        <property type="protein sequence ID" value="KJB09026"/>
        <property type="gene ID" value="B456_001G119900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SAEA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRDANNC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8264" checksum="E9AA8F84A04C9EBB" modified="2015-04-29" version="1">MAATIAARSSFLRPVLRTATASRISFSVPNSSLRSTSTQLSTLQPVHSAVASACLVSKLPRDANNCAEGRFANYLIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYY7</accession>
    <name>A0A0D2PYY7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G142200</name>
        <name evidence="3" type="ORF">Gorai_021207</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYY7"/>
    <dbReference type="STRING" id="29730.A0A0D2PYY7"/>
    <dbReference type="Gramene" id="KJB09436">
        <property type="protein sequence ID" value="KJB09436"/>
        <property type="gene ID" value="B456_001G142200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794636"/>
    <dbReference type="eggNOG" id="ENOG502QU85">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRTATKF"/>
    <dbReference type="OrthoDB" id="740966at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF24">
        <property type="entry name" value="G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB09436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0578936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="43206" checksum="B2A097B325AB6C48" modified="2015-04-29" version="1">MKSQVAFTDEDDCESCRLAYCWWRTATKFDECAKLKLDFPDVSILTPRLRLLRELERLALIAPDGLNELRHKLLGYRSGDFWVPIGGINKEDMDIPPVNTILLVGFSGSGKSSLINLMYSILGRSGLIPFAQTSSGSCSNYTTMYMEEHNVLRSMRSGFCVYDSRGFDYGRTREALEELSSWMSEGVHHNQLCLRYRDSKMMTDDMENDDMGSSSKFVLRRVNCVIVVANMAEIYQALKAGDLKPLEAIRQLFCCAALRNSNENPLVILTHGDLLSTEERIDGRLKICECLDISETNGVYDIVCLTEYGFLEEECDPVSAYALTEVVYRALLISDRGQLPKKRFHHRALLILLCLVRFIGVCFAFLADVCSRLGEKEKLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q157</accession>
    <name>A0A0D2Q157_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G194400</name>
        <name evidence="13" type="ORF">Gorai_021509</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be a cell surface adhesion protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fasciclin-like AGP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q157"/>
    <dbReference type="STRING" id="29730.A0A0D2Q157"/>
    <dbReference type="Gramene" id="KJB10289">
        <property type="protein sequence ID" value="KJB10289"/>
        <property type="gene ID" value="B456_001G194400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10290">
        <property type="protein sequence ID" value="KJB10290"/>
        <property type="gene ID" value="B456_001G194400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10291">
        <property type="protein sequence ID" value="KJB10291"/>
        <property type="gene ID" value="B456_001G194400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10292">
        <property type="protein sequence ID" value="KJB10292"/>
        <property type="gene ID" value="B456_001G194400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799989"/>
    <dbReference type="eggNOG" id="ENOG502QV96">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMNLCIW"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009834">
        <property type="term" value="P:plant-type secondary cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000012">
        <property type="entry name" value="Fasciclin-like arabinogalactan protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045003">
        <property type="entry name" value="FLA_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32077">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32077:SF3">
        <property type="entry name" value="FASCICLIN-LIKE ARABINOGALACTAN PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395310" description="FAS1 domain-containing protein" evidence="10">
        <location>
            <begin position="26"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="11">
        <location>
            <begin position="48"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="201"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="214"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0579248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="265" mass="28319" checksum="F3B024F2E587ADFF" modified="2015-04-29" version="1">MEFSKIFTICFSVLLLCSSLAYGQARSPPAPVAMSPTPTPAPAPAPPYVNLTYLLSVAGPFHTFLDYLESTKVIDTFQNQANNTDQGITVFVPKDSAFKDLRKPSFSNLSDDQLKSLILYHALPRFYTLADFNELSTKGSISTLAGGEYTLNFTYDSGTVHLDSGWSKTKVTSAVHSTDPVAIYQVDKVLLPEAIFGTDIPPTPAPSPAPVPDVSPAADSPSAESKESGSSPKSAPSTSSSNSIMNLCIWRQLVLAVSAGVVLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q6Z9</accession>
    <name>A0A0D2Q6Z9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G014000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q6Z9"/>
    <dbReference type="STRING" id="29730.A0A0D2Q6Z9"/>
    <dbReference type="Gramene" id="KJB53967">
        <property type="protein sequence ID" value="KJB53967"/>
        <property type="gene ID" value="B456_009G014000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCELLWM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF8">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="913"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="942"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB53967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="968" mass="109167" checksum="CA50EEC05470DF1A" modified="2015-04-29" version="1">MLNNSIFSSLGVLSNLKYLYLYHNKLKGRIHMKDLNSLRYLKELDLSDNKVTELVPSQAELRLMNLRVVDLSDNLFNNTILSSLAGLSNLKTLSLWNVRGPIDMNDGLRNLEELHMSCYSEWQILANLVDLILEDSSLPLNFIPTLSSLKYLHLSSCYVNDSFFMHERQNLRNLEELLLEYSSLPSNFIQVIGPLTSLKKFYSPLPRNVNQSLSDFCKMTNLRELFISGNNLKGSLPMCFSNLTSLEKLDLSFNDLSGNMSALKSLASLQRLDLSFNDLSGNMSALKSLASLQWLDLSYNKLQIPSSLGYLFNLSKLQYLSASNNIIYVDEMHSVAPRFQLRVISLSCCGNGGSFPQFLYHQHDLVDVTLSHIHFKVNQFPFWLLENNTNLKRLHLVNCSLSGPFQVPFPSHLVLEDLDISNNFFSGNIPTEIGAHLPSLSSLNMSKNDFNGSIPSSFGDMSSLQILDLSNNQLFGGIPEHFAWGCSLLEILALSNNTLQGPIFSTNFSLMSLSQLQLNGNNFSGMIPNALSNCSFLGTLDLSNNYLFGKIPSWIESMYSLSTFDVSRNQLSGRIPQWMGNTSNLGQIDVADNHLQGLIPRAFCNLNRQLQFLDLSMNNFSGILPSCFKPSNIEEVYLSKNMLQGPLPNAFRKSSFLVTLDLSYNHFSGHIPNWISNLSQLSYLLLKRNHFEGEIPIQLCKLPHLSLIDLSMNNLSGGIPSCLKVTALNKVPDHYSWISYNFFGENRSISIEESIEYTIKSRSYTYKKRILQYMSGIDLSCNKLTGEIPHEIKNILMLYTLNLSHNSLIGPIPREFSNLRDIESLDLSYNNLTGNIPPEYALLHFLQYFNVSYNNLSGKTPEKIGQLGTFDESSYVGNPFLCGSLVGKNCSPIAPTKAPSDGAKDHGFIDMDAFYASFFACYIVVLLCIGAVLYINPYWRQAWLYYVQMTINSCYYFVMDNLPRNFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q7F9</accession>
    <name>A0A0D2Q7F9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G108700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q7F9"/>
    <dbReference type="STRING" id="29730.A0A0D2Q7F9"/>
    <dbReference type="Gramene" id="KJB35303">
        <property type="protein sequence ID" value="KJB35303"/>
        <property type="gene ID" value="B456_006G108700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S200">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERTHIWS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021475">
        <property type="entry name" value="Pants/Emi1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28052:SF1">
        <property type="entry name" value="UPF0545 PROTEIN C22ORF39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11326">
        <property type="entry name" value="PANTS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB35303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="106" mass="12639" checksum="5F4E91908F1B040A" modified="2015-04-29" version="1">MSAEKESSISQHRLSCTKCFDALWFCYSPVHQLQQYYREGVLDNCYGKWRALWDCLYLKTKPSSQLQEILEAREKAESHIWTFRTPEEAQAFWKQEFGHLNGRESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBD9</accession>
    <name>A0A0D2QBD9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G114200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QBD9"/>
    <dbReference type="SMR" id="A0A0D2QBD9"/>
    <dbReference type="STRING" id="29730.A0A0D2QBD9"/>
    <dbReference type="Gramene" id="KJB14206">
        <property type="protein sequence ID" value="KJB14206"/>
        <property type="gene ID" value="B456_002G114200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783405"/>
    <dbReference type="eggNOG" id="ENOG502QRGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DLSCKFC"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000005">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000003">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249629" description="glucan endo-1,3-beta-D-glucosidase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="12">
        <location>
            <begin position="368"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="456" mass="49786" checksum="665BF2188FEE6DE1" modified="2015-04-29" version="1">MALHLFHLLLFLLLSPLSYVSSVGINYGTLGNNLPSPKKVAQLLQSTLIDKVKIYDTNPDILEAFSNTGIDLIVAVENYHVANISKDAAAADDWFATRVQPFIPATSIVAVCVGNEYLTSDDNLDPDALVQAMQNLHAVLLKRGLDRKIKVTTPHSMAVLASSFPPSASTFATKLIPTMSSIVGFLADTGAPFMVNAYPYFAYRDNPSTVDLEYALLGNSTGVHDPKGYIYHNMLDAQIDAVRSAIDAIGFGNLSMKITVSESGWPSKGDSEDTAATPNNAKTYNTRLIERAQSNKGTPMKPKDNIEIFVFALFNENKKPGGASERNFGIFNGDGSKVYEVDLSCEFCSNGGAFEKMSTSGQVRGPSVWCVAKPHADEKVLQTVLDFCCGPGGVDCREVYESGKCFEPDKLHAHASYAMNAYYQMHGRNYWNCDFKGTGLVTFSDPSYGTCRYRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QD89</accession>
    <name>A0A0D2QD89_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G104300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QD89"/>
    <dbReference type="Gramene" id="KJB56032">
        <property type="protein sequence ID" value="KJB56032"/>
        <property type="gene ID" value="B456_009G104300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB56032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="72" mass="8176" checksum="335BC8CBF2997540" modified="2015-04-29" version="1">MKQNQTGVTSNSKTSLVSPGPTFPKAILHSNPELSPPLLPEELFCLLKYSDQIYITLKKKKTFLFLRNQILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEF3</accession>
    <name>A0A0D2QEF3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G017500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN-RELATED"/>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="KJB17824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="139" mass="15722" checksum="9661EC6B8B93A684" modified="2015-04-29" version="1">MSWRFPPRGWLKFNVCGVVFKDKAGGGGVLRDEDGVARALFSSPSEVKDAELSIGVALELYEGMGWATCCPLFIEVGSNEVFKWLSEIESRLGKLHYFFAEIERRSYLSFRKAEHMGNEMAFALAIVGVKRSDTFKAWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFT7</accession>
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    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="gene ID" value="B456_003G049800"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
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        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
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        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="4"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB18384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="329" mass="37323" checksum="FB3AF78E8FD94AEA" modified="2015-04-29" version="1">MYKMGRGKLNMKFIMKDKVRILTYEKRKKGLIKKAQEFSILCGVETCVILYAPKSKETPAKLEIWPPDHAKVMHVIDKYKGKPLHVRERKCFNVLDFYAIRRKKLDDEICKLRKANTEAKFSVWDDRINSFSVNQLSALLSRLDSNLESARTMIKMIKGKHQSLIEDSTENQLNQPSLDLYNQAQLSLFQRASDMEITKQQQPMFTVSSSCQPFSSNEPLQWQSVNMNPIDTSMAMVSTNGTLGFTQADGECSSSTTYSSLTPQTCYDPTTSMVGNVVLSNSWGVPVCFYGQLMPPMTPFASPTMLSFPSQAGELYRNVGDRVRSINKK</sequence>
</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33181:SF19">
        <property type="entry name" value="OS04G0658200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB57122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="94" mass="11236" checksum="2B9EDE1DDC55ACFD" modified="2015-04-29" version="1">MDWWHKMIFPVRRLWFVVSSRVKARKNGAGLLKLHDDVQTCGYEDVQVMWEMLRRSESELLAANNNPKRKHRPAFWRVFVWSSNHTSSFSPNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QK37</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
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    <organism evidence="1 2">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Transfers an alpha-D-xylosyl residue from UDP-D-xylose to a glucose residue in xyloglucan, forming an alpha-(1-&gt;6)-D-xylosyl-D-glucose linkage.</text>
            <dbReference type="EC" id="2.4.2.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 34 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.39" evidence="12"/>
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        <property type="protein sequence ID" value="KJB41948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QRS0"/>
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        <property type="protein sequence ID" value="KJB41948"/>
        <property type="gene ID" value="B456_007G128800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803025"/>
    <dbReference type="eggNOG" id="KOG4748">
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    <dbReference type="OrthoDB" id="205108at2759"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008630">
        <property type="entry name" value="Glyco_trans_34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311:SF5">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31311">
        <property type="entry name" value="XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05637">
        <property type="entry name" value="Glyco_transf_34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
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            <dbReference type="ARBA" id="ARBA00022676"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
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        <name evidence="4" type="ORF">Gorai_013574</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39158">
        <property type="entry name" value="OS08G0560600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
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            <end position="169"/>
        </location>
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            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09350"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0596765.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="236" mass="26567" checksum="9397FE68E3B6CE10" modified="2015-04-29" version="1">MATRLARKLPSSFSAFSSSPITKLTWGISPPSMSHGGPGLRCASSSSSSSSSTTTTGSNSSSSKREKKITDRLSAAIDAVNDRKLPPELRGQRNKVRSETDIINVVEQRIWHSMEEGQFENLAGKGKPLNLNTTPHADPAEDTLYRILSKNGCAPEWVELNKEIRNKVSEWRVALKKAWTSKCNGNDEEKWIERCESLKKQLRDINDKVFRYNLIVPFGRQMFGLKWEKEVARLEE</sequence>
</entry>
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    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
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        <property type="protein sequence ID" value="KJB24674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0584031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_004G156800"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACOT13"/>
    </dbReference>
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        <property type="entry name" value="HotDog_dom_sf"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF12">
        <property type="entry name" value="OS07G0462700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
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    </dbReference>
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    </dbReference>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB24674.1"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="191" mass="20337" checksum="1771040BCD115F7E" modified="2015-04-29" version="1">MANPSSKATVPGSRELQASSTSPGGAATSTKSDDGANPYEPQVMRFLKRVGMHDPNVENYSSRDFYSNLLCNTLKTHTVRRGHVTCFATVTPAVANYFGGLHGGAVAAIAERVAIATTRTVVGEDKEIFLVDLGMSYLSAAPKDAELIVDGAVVKSGRNITAVSIEFKMKKTGKLLFTSRATFHNSPLAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB44788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB44788"/>
        <property type="gene ID" value="B456_007G273400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB44789">
        <property type="protein sequence ID" value="KJB44789"/>
        <property type="gene ID" value="B456_007G273400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB44788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="75" mass="8679" checksum="68BC05EDC8103AD5" modified="2015-04-29" version="1">MFGFRVSHPILYLAFDILFSILGSFRVLIGTCWMKEREMMNMELPRGIEGRFQGQVFNGNIIAQSKNGFAYEPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4A8</accession>
    <name>A0A0D2R4A8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G258400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4A8"/>
    <dbReference type="Gramene" id="KJB26764">
        <property type="protein sequence ID" value="KJB26764"/>
        <property type="gene ID" value="B456_004G258400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792685"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMGEYDP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904659">
        <property type="term" value="P:D-glucose transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17362">
        <property type="entry name" value="MFS_GLUT10_12_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000118">
        <property type="entry name" value="D-xylose-proton symporter-like 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050820">
        <property type="entry name" value="MFS_Sugar_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48023">
        <property type="entry name" value="D-XYLOSE-PROTON SYMPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48023:SF4">
        <property type="entry name" value="D-XYLOSE-PROTON SYMPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="48"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB26764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="501" mass="53246" checksum="9AFE1E30121E5843" modified="2015-04-29" version="1">MASDHEQPGLSSLGKVGRSSGEIGSEHEPLVNGIHTSESYSASAAILPFLFPALGGLLYGYDIGATSCATISIESATLSGISWYDLSSVEVGLITSGSLYGALIGSVLAFNIADFLGRRRELIMASIMYLVGALVTAFAPNLVVMVIGRFVYGIGIGLAMHAAPMYIAETAPSQIRGILISLKEFFIVLGMVAGYGIGSLLVETVSGWRYMYGASTPLAVIMGIGMCWLPASPRWLLLRAIQGKGNMQELRETAVCCLCRLRGQSIGDSASQHVDEILTELSYVGEEKEVTLGEIFHGKCLKAMIIGAGLVLFQQITGQPSVLYYAASILQSAGFSAASDATRVSILLGLLKLIMTGVAVVVVDRLGRRPLLLGGVSGMVISLFLLGSYYLFLDDLAAIAVVALLLYVGCYQLSFGPIGWLMISEVFPLRLRGRGLSVAVLVNFGANALVTFAFSPLKAWLGAGIVFYVFGVIAVLSLVFIFFIVPETKGLTLEEIEVKCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R6T0</accession>
    <name>A0A0D2R6T0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G181900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R6T0"/>
    <dbReference type="STRING" id="29730.A0A0D2R6T0"/>
    <dbReference type="Gramene" id="KJB25186">
        <property type="protein sequence ID" value="KJB25186"/>
        <property type="gene ID" value="B456_004G181900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25187">
        <property type="protein sequence ID" value="KJB25187"/>
        <property type="gene ID" value="B456_004G181900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25188">
        <property type="protein sequence ID" value="KJB25188"/>
        <property type="gene ID" value="B456_004G181900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791891"/>
    <dbReference type="eggNOG" id="ENOG502QUJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GTINPDW"/>
    <dbReference type="OrthoDB" id="1642657at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044827">
        <property type="entry name" value="GBF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012900">
        <property type="entry name" value="MFMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967:SF2">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967">
        <property type="entry name" value="G-BOX-BINDING FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07777">
        <property type="entry name" value="MFMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16596">
        <property type="entry name" value="MFMR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="308"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="368"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="175"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="317"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB25186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="406" mass="43004" checksum="7E66B7EDF4B11DD7" modified="2015-04-29" version="1">MGSSEMDKAAKEKEPKTPPAITAQESSSTTNSGSVNADWSGFQAYSPIPPHGFLASSPQAPPYMWGVQHIMPPYGTPPHPYVAMYPHGGIYAHPSLPPGSYPFSPFAMPSPNGIAEASGNTPGSMEMDGKPPEVKEKLPIKRSKGSLGSLNMITGKNNNLGKTSGASANGGYSKSADSGSEGTSEGSDANSQNDSQLQSGDGKDSGEGEASQNGRSAHGPQNGGPNSAHSVANTALAIVPISTTGAATAVPGPTTNLHIGMDYWGTPASSNVPAMHAKVPSTPVAGGIVTPGSRDNVQSQLWLQDERELKRQRRKQSNRESARRSRLRKQAECDELAQRAEALKEENANLRSEVSRLKSEYEQLHAENASLKERLGEIPGHEDLKSGRNDQHRNEDEQTEIVQGSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R739</accession>
    <name>A0A0D2R739_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G162300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R739"/>
    <dbReference type="Gramene" id="KJB15130">
        <property type="protein sequence ID" value="KJB15130"/>
        <property type="gene ID" value="B456_002G162300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785513"/>
    <dbReference type="eggNOG" id="KOG0061">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSNHGDV"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000367">
        <property type="entry name" value="ABC transporter G family member 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF107">
        <property type="entry name" value="WHITE-BROWN COMPLEX HOMOLOG PROTEIN 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262466" description="ABC transporter domain-containing protein" evidence="11">
        <location>
            <begin position="26"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="855"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="884"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="960"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="494"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="324"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1081" mass="118917" checksum="D28C81AC3D934D87" modified="2015-04-29" version="1">MRGVIRSHFLHFLLFFLSSFPSSRSLDGDDYSETQNPAVLPGVTDLIHKRLSNLTTLLIKDIGSDLSFCIKNAQEDLDGAFNFSKNMDFVTNCIKKTKGDVTLRLCTAAEIKFYFDSLFSKGAKTGYVKVNKNCNLKSWVSGCEPGWGCFADGGQQIDLKNTSYMPSRSQDCQPCCEGFFCPRGLACMIPCPLGSYCPLATLNKTTGVCDPYNYQIPPGKPNHSCGTADIWADVGSSSEIFCSAGSYCPNTLNKITCSKGHYCRKGSTSQISCFKLTTCNPNTSNQNIHGYGVMLFVGLSLLLLIIYNFSDQVISTKERRQAKSREAAAKHARETAQARERWKAAKDIAKKGGWQAQLSKTFSRAKSQRKTEQQKASGVGKSTEAPVPPPPKVAEQTSKGSKEKKKEPGDLTKMLHSLEDDPKSNEGFDLNIGGKNVKKQAPKGKQLHTQSQIFKYAYGQIEKEKAQQNKNLTFSGIISMATDNDIRTRPMIEIYFKDLTLTLKGKNKNLLRSVTGKLMPGRVSAVMGPSGAGKTTFLSALTGKTAAGCSVTGLILVNGKNEPIQAYRKIIGYVPQDDIVHGNLTVEENLRFSARCRLSADLAKPDKVLVIERVIESLGLQAVRDSLVGTVEKRGISGGQRKRVNVGLEMVMEPSLLILDEPTTGLDSSSSQLLLRALRREALEGVNICMVLHQPSYTLFKMFDDLILLAKGGLVAYLGPVKKVEEYFSSIGINVPDRVNPPDHLIDILEGIEKPATVTREQLPVRWMLHNGYPVPLDMLDLAEGLSTPSGSNPNNSGATAGGQAFAGDLPDDAKINVSKSKDLSNRRSPGILRQYRYFLGRILKQRLREGQMQAVDLMILLLAGACLGTLAKVTDETLDNAGYTFSVIAVSLLSMIAALRTYSLDKLQYKRETESGISSLAHFLSKDTIDLFNIIIKPVAYLSMFYFFNNPRSSFQDNYVILMALVYCVTGMAYVLAISFAPSLAQLWAVLVPVVLTLVANKGKDSMIQKYFGKFCYTKWALEAFVIANAEKYSGVWLLTRCKSLESGGYNLHDWKLCLIILIVNGVIARILAFIILVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R7F9</accession>
    <name>A0A0D2R7F9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G190000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VPS53 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R7F9"/>
    <dbReference type="STRING" id="29730.A0A0D2R7F9"/>
    <dbReference type="Gramene" id="KJB25401">
        <property type="protein sequence ID" value="KJB25401"/>
        <property type="gene ID" value="B456_004G190000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25404">
        <property type="protein sequence ID" value="KJB25404"/>
        <property type="gene ID" value="B456_004G190000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791979"/>
    <dbReference type="eggNOG" id="KOG2180">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.110:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53 A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.110">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 53, C-terminus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031745">
        <property type="entry name" value="Vps53_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038260">
        <property type="entry name" value="Vps53_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16854">
        <property type="entry name" value="VPS53_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MHD1" evidence="8">
        <location>
            <begin position="357"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="322"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="738"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB25401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="824" mass="91766" checksum="EA161292189C577F" modified="2015-04-29" version="1">MDKMSTLEYINQMFPTEASLSGVEPLMQKIQSEIRRVDAGILAAVRQQSNSGTKAKEDLAAATHAVEELTYKIREIKTKAEQSEMMVQEICRDIKKLDFAKKHITTTITALHRLTMLVSAVEQLQIMASKRQYKEAAAQLEAVNQLCSHFEAYRDIPKITELREKFKSIKQILKSHVFSDFSSLGTGKESEETNLLQHLSDACLVVDALEPSVKEELVNNFCSRELTSYEQIFEGAELAKLDKTERRYAWIKRRMRTNEEIWKIFPTSWLVPYRLCIQFCKKTRKQLEGILDNMKEKPDVATLLMALQRTLEFEDELAEKFGGGTQSREIGNEIEEIGRQNNSQSASDIRKKYEKKLSAHQGSENEEKDGNKDLSAPGAGFNFHGIISSCFEPHLIVYIELEEKTLMENLEKLVQEETWDVEEGSQNNVLSSSMQLFLIIKRSLKRCSALTKSQTLYNLFKVFQRVLKAYATKLFGRLPKGGTGIVAAATGMDGQIKTSDRDERVICYIVNSAEYCHKTSGELAESVSKIIDSQFADRVDMSEVQDEFSAVITKSLVTLVHGLETKFDAEMAAMTRVPWGTLESVGDQSGYVNGINMILSSSIPVLGSLLSPIYFQFFLDKLASSVGPRFYMNIFKCKQISETGAQQMLLDTQAVKTILLEIPSLGRQTSGAAGYSKFVSREMSKAEALLKVILSPVDSVADTYRALLPEGTPMEFQRILELKGLKKSDQQSILDDFNKGSPAISQPSSAAPVGQSMAPAPPASTVPAISNPASAGFIASREDVLTRAAALGRGAATTGFKRFLALTEAAKDRKDGPFRKLFNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R7J1</accession>
    <name>A0A0D2R7J1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Xrn1 helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G135400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R7J1"/>
    <dbReference type="STRING" id="29730.A0A0D2R7J1"/>
    <dbReference type="Gramene" id="KJB66322">
        <property type="protein sequence ID" value="KJB66322"/>
        <property type="gene ID" value="B456_010G135400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2044">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSTKCDM"/>
    <dbReference type="OrthoDB" id="976623at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="109" mass="12772" checksum="E98AEECC1B895721" modified="2015-04-29" version="1">MTDPNSPIIDFYPTDFEVDMNGKRYSWQGLAKLPFIDEEQLLAEVAKIEHTLTDEEAQRNSTVCDMLFVAASHRLSEQIFSLDSRKQLPERQQIEVKEEVKPNLRWDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RA58</accession>
    <name>A0A0D2RA58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G054800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nibrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RA58"/>
    <dbReference type="STRING" id="29730.A0A0D2RA58"/>
    <dbReference type="Gramene" id="KJB48163">
        <property type="protein sequence ID" value="KJB48163"/>
        <property type="gene ID" value="B456_008G054800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763133"/>
    <dbReference type="eggNOG" id="ENOG502QQ7Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDETCHV"/>
    <dbReference type="OrthoDB" id="980445at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22667">
        <property type="entry name" value="FHA_NBN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000017">
        <property type="entry name" value="Nibrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="10">
        <location>
            <begin position="31"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="11">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="523"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB48163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61546" checksum="C1A9345E2280F0A0" modified="2015-04-29" version="1">MVWALLPVDPSSAEQEEEEEDKYYIFKNGTYSVGRKGCDIIIHKDKGVSRIHAHIMVDEMTQSCQVRIRDLSKYGTFINKNLSSNKKVHHFPNKQTSLEDGDLLSFGTGNATFRFSYVPLVLYICCAEASQMNHHLQDKVSSIGARLTHVYSEDCTHVIVDQHVPLKRDLLDAIVAKKPLLRTSWLELVAERSIQTKFPDCCSHVPTIMVDGVFVEVSDPKTRENCLGGYTFLLESTQVYKFGDRLQSLLEVSGSRVNYVEEICSSSQAFGCGENTCLTYVIPGRSVDKFDHLDNLGLSYRVDEMALIRALLSGKLDQSILISSSVPVSSSCSTDETVVADSDEEIEMATSVNVNATTCKEGAQNYVSRDGISMEAPSCVSKAEVPTCQDAIRLKDDRVTSKDDNCCLTARRDEADQVTSKDDNCCLTARRDKADESEYGSSNIVYSQVLIVRDVNITSKNSFKEDNGVINYKRFRKASIQSGNSFNNLVPFSKHPYKDYEFGSGDLAESVKEEKKRKKMDAIADDMFNSEKGGRQRGLSGSLRRGLLHTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RB64</accession>
    <name>A0A0D2RB64_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G071100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RB64"/>
    <dbReference type="STRING" id="29730.A0A0D2RB64"/>
    <dbReference type="Gramene" id="KJB48483">
        <property type="protein sequence ID" value="KJB48483"/>
        <property type="gene ID" value="B456_008G071100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763316"/>
    <dbReference type="eggNOG" id="ENOG502RZ4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRCKSVT"/>
    <dbReference type="OrthoDB" id="843671at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB48483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="152" mass="16467" checksum="044607984D308D41" modified="2015-04-29" version="1">MGICSSCDSNHAATAKLILQNGRLQEFPYPVKVSYVLQGNPTCFICNSDEMDFDDVVSAVEEDEELQPGQLYFALPLSWLKHPLQPQQMGALAVKASSALMKSNSGSEKCGCRCKSVTPFPVPEEVASVGGGEKRGRGGRRKFKAILSDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDT6</accession>
    <name>A0A0D2RDT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S54 rhomboid domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G126600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDT6"/>
    <dbReference type="STRING" id="29730.A0A0D2RDT6"/>
    <dbReference type="Gramene" id="KJB29979">
        <property type="protein sequence ID" value="KJB29979"/>
        <property type="gene ID" value="B456_005G126600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794000"/>
    <dbReference type="eggNOG" id="KOG2632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWAFAFI"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000008">
        <property type="entry name" value="RHOMBOID-like protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF32">
        <property type="entry name" value="PEPTIDASE S54 RHOMBOID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="49"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB29979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="269" mass="30163" checksum="045A5EE0369FB204" modified="2015-04-29" version="1">MGKPLFYEILEKPATSCIIGICSGIWFYIQKKNIGYQHVGLSYETAIEGHHWRVITSSFSHISVLHLVFNMSALWSLGVIEQLDHLGLGVANYLHYTLVLVVFSGLLVLGMYHFLIQRFKIEYFRRVTAVGYSCVVFGWMTILSVKQPSSKLDLFGFLSLPISFAPFESLIFTSIIVPQASFLGHLSGIIVGYAIAWGLIHGMTNYWAVSMLGWIAVVFIFSLKHSGAYDLSFLEIESVTDPSLPSVRFIRNGRTLQMNTVPVEGIQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2REQ0</accession>
    <name>A0A0D2REQ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DFDF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G137500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">As a component of the decapping complex, involved in the degradation of mRNAs. Promotes P-body formation. Translational repressor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LSM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2REQ0"/>
    <dbReference type="STRING" id="29730.A0A0D2REQ0"/>
    <dbReference type="Gramene" id="KJB30324">
        <property type="protein sequence ID" value="KJB30324"/>
        <property type="gene ID" value="B456_005G137500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794148"/>
    <dbReference type="eggNOG" id="KOG1073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000033">
        <property type="entry name" value="Trailer hitch, isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="9"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="10">
        <location>
            <begin position="433"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="11">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="12">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="7">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="8">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB30324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="61285" checksum="D740788D776FB96B" modified="2015-04-29" version="1">METDSSSTKSGSTADSYIGSVISLTSKSEIRYEGVLYNINPDESSIGLKNVRSFGTEGRKKDGPQVPPSDKVYEYILFRGSDIKDLQVKSSPPAQPTPPINDDPAIIQSQFPHPVSTTTSAPSAATRPLTDPTTHAAQMGLPGSNYQAALPLYLPGGNLGSWGASPPPPTANGNGLPMPMYWEGYYGPPNRPPHLHHQSLLRPSPGQSMPPFMQQPMQYPNFNAPFLIGLGNLQSSSLPEAPPPLFPPSTGSPNVTSTLSSDLPPAPSASLASEALLNKAPSPTISPAALGASLPAISPLTTGPELSPIVPPIAHKPSTNPTVLHQTTSQAASSIIGVSNSVSMETPTPSMVTPGQLLESGTTVVPSPQPDATVHKDVEVVQVFSSPTEPSASVVSEAQPPILPLPSAAHKPNGASFQPRHGYRGRGQGRGTWNSRPVTKFTEDFDFMAMNEKFKKEEVWGHLGKSSKSNSKDKEGDASDKDGYQDEDDAETSKIQAKPVYNKDDFFDALSCNALDKDTQNGRPRFSEQMKLDTETFGVFSRHRGGRGGRFRGGYHGRGYGHVGRGSGRAMSMRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNQ0</accession>
    <name>A0A0D2RNQ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_008G278700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNQ0"/>
    <dbReference type="STRING" id="29730.A0A0D2RNQ0"/>
    <dbReference type="Gramene" id="KJB52813">
        <property type="protein sequence ID" value="KJB52813"/>
        <property type="gene ID" value="B456_008G278700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765558"/>
    <dbReference type="OMA" id="ENIFATW"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000004">
        <property type="entry name" value="Berberine bridge enzyme-like 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32448">
        <property type="entry name" value="OS08G0158400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0134">Cell wall</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250336" description="FAD-binding PCMH-type domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="14">
        <location>
            <begin position="70"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="535" mass="60200" checksum="4C78386FD0CD2A6E" modified="2015-04-29" version="1">MFPSLFVILLSVSWKSSSTLAYPSEGFLHCLSLHFANSTSISKLVYTQRNSSFSSVLKSSAQNFRFTTPSTPTPLFIITPLQPSHIQAAIYCSRIHGLHVRTRSGGHDFEGLSYTTANYIVPFVVIDLVNLRSVQVDVEKATAWVESGATIGELYYGIAQKSRTLAFPAGLFYTVGVGGQFSGGGYGPLFRKYGLAADNVIDARLIDAKGRILDRKSMGEDLFWAIRGGGGGSFGIVLAWKLKLVAVPAIVTVFTVSKTLEQNATKLVHRWQSIAHKFPKELLMSIFISSVKSSEADKKMTIKANFSSMFLGSIDELVPLMEERFPEFGLVRDDCLEMSWVEAILSTQGGVQLETLLERHQKTGVSQTFFKAKFDCVKQPIPEMGLEGLWPMFYEEEAKMANIFLVAYGGKMDEIPETEIPFPHRAGIIYSIIYVVDWDENGNKNSKRFLNWIRRVYDYMTPYVSNSPREAYVNYKDLQIGSNNMFSCKGSYAQAKIWGRKYFKNNFDRLVYVKTKVDPENFFRHEQSIPPLSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQ32</accession>
    <name>A0A0D2RQ32_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_008G079200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQ32"/>
    <dbReference type="STRING" id="29730.A0A0D2RQ32"/>
    <dbReference type="Gramene" id="KJB53283">
        <property type="protein sequence ID" value="KJB53283"/>
        <property type="gene ID" value="B456_008G079200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763391"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKEMSDQ"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20653">
        <property type="entry name" value="CYP81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000023">
        <property type="entry name" value="Cytochrome P450 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050651">
        <property type="entry name" value="Plant_Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947:SF26">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47947">
        <property type="entry name" value="CYTOCHROME P450 82C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266793" description="Cytochrome P450" evidence="14">
        <location>
            <begin position="27"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="57232" checksum="543D19DB082D1450" modified="2015-04-29" version="1">MKMEEILICSLLSVLILWVATKLITSTHKNHPPSPLALPILGHLHLLKEPLHRTLFTLSQKHGPIFSLKLGSRFLVVVSSPSTVQECFTKNDIVLANRPRFIMGKYVGYNYTTLGLAPYGDHWRNLRRLSTIDIFSSTRLNMSLDIRRDEVSRLLRRLYQVSADGFAKVELKSVFSELTFNIIMRMMAGKRYFGDEATQNSDEGRRFRKMIKELFELAVSSYPGDFLPILQLVDYDGYIKRIKDLGSKTDELMQGMIHEHRSKKGDLNIKNTMITHLLSMQESQPEYYTDEIIKGLIQVILNAGTDTTAITLEWAMSNLLNNPHVLEKARAELDKLVGQEKLVEEADVAKLPYLQSIISETLRLYPAAPLLVPHSASEICSIEGYEIPKDAIVMVNAWAIQRDPNLWDDALSFKPERFEEGKEMSDQIYKLMPFGLGRRACPGMVLAQHVLGLTLGALIQCFEWERVSEKKIDMTDGQGLTMPKVQPLEAMCKASQLGKKLLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVH5</accession>
    <name>A0A0D2RVH5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G082300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVH5"/>
    <dbReference type="STRING" id="29730.A0A0D2RVH5"/>
    <dbReference type="Gramene" id="KJB23105">
        <property type="protein sequence ID" value="KJB23105"/>
        <property type="gene ID" value="B456_004G082300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790746"/>
    <dbReference type="eggNOG" id="ENOG502QQ6J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWGDEVP"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02325">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039629">
        <property type="entry name" value="R3HDM4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32019:SF2">
        <property type="entry name" value="R3H DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="249" mass="28212" checksum="A7295E0D2D1274D8" modified="2015-04-29" version="1">MATPGVLQRETDLLLSSPLIELRKGENGKSRGLSIEKKIELLESLTGKVTNRRSRRWLNDRLLMELVPRLNAEEVRGLFAPPPWGDDVPPSAFCMTNVGEWDKFRTIDMDKEANIIGALNNSSMKKKFHADADKAAFLSAWLRVDCRTREALRRSFLSDLIASYEDCIRTFIQERGHGDVLALQVQDPFHRLLLHGVCEFYNVVSVTVTQSKGAESLKVTRIKKKKTGVVELPNITLSNFLKMSKEGIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RY88</accession>
    <name>A0A0D2RY88_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G107200</name>
        <name evidence="11" type="ORF">Gorai_011567</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RY88"/>
    <dbReference type="STRING" id="29730.A0A0D2RY88"/>
    <dbReference type="Gramene" id="KJB56128">
        <property type="protein sequence ID" value="KJB56128"/>
        <property type="gene ID" value="B456_009G107200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769196"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMITMVE"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000001">
        <property type="entry name" value="Probable aquaporin PIP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB56128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0594670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="289" mass="31002" checksum="49A3AB586DB54B7D" modified="2015-04-29" version="1">MTKDIETAEQHGGEFSAKDYHDPPPAPLIDAEELTKWSFYRAVIAEFIATLLFLYVTVLTVIGYKVQTDPAKNTVDPDCGGVGILGIAWAFGGMIFILVYCTAGISGGHINPAVTFGLFVGRKVSLIRALMYMVAQCLGAICGCGLVKAFQKTYYNNYGGGANELQPGFNKGTGLGAEIIGTFVLVYTVFAATDPKRNARDSHVPVLAPLPIGFAVFMVHLATIPVTGTGINPARSFGAAVIYNKEKAWDDQWIFWVGPFIGAAAAAFYHQYILRAAAIKALGSFRSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1J1</accession>
    <name>A0A0D2S1J1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Meiotic recombination protein DMC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G243000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S1J1"/>
    <dbReference type="STRING" id="29730.A0A0D2S1J1"/>
    <dbReference type="Gramene" id="KJB38194">
        <property type="protein sequence ID" value="KJB38194"/>
        <property type="gene ID" value="B456_006G243000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEVCTRR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19514">
        <property type="entry name" value="DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000043">
        <property type="entry name" value="Meiotic recombination protein DMC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="11">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="12">
        <location>
            <begin position="281"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB38194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="344" mass="37551" checksum="0178B3ABD98ED6A4" modified="2015-04-29" version="1">MIATLKAEEASQLQLVEREDIDDEEDLFESIDKLISAGINAGDVKKLQDAGIYTCNGLMMHTKKNLTGIKGLSEAKVDKIREAAEKIVNFGYITGSDALLRRKSVIRITTGSQSLDELLGGGIETSAITEAFGEFRSGKTQLAHTLCVSTQLPTNMRGGNGKVAYIDTEGTFRPDRIIPIAERFGMDPAAVLDNIVYARAYTYEHQYNLLLGLAAKMSGEQFRLLIVDSVIALFRVDFTGRGELAERQQKLAQMLSRLTKIAEEFNVAVYMTNQVIADPGGGVFISDPKKPAGGHVLAHAATIRLMFRKGKGEQRVCKVFDAPNLPEAEHVFQITPGGIADAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S202</accession>
    <name>A0A0D2S202_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="3">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G183400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="2.4.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S202"/>
    <dbReference type="STRING" id="29730.A0A0D2S202"/>
    <dbReference type="Gramene" id="KJB25285">
        <property type="protein sequence ID" value="KJB25285"/>
        <property type="gene ID" value="B456_004G183400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25287">
        <property type="protein sequence ID" value="KJB25287"/>
        <property type="gene ID" value="B456_004G183400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791914"/>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000010">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000052">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000054">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000017">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF94">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB25285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="862" mass="97670" checksum="BBAF585BCA8726D2" modified="2015-04-29" version="1">MVSRSYSNLLDLAYGGTPTLSQEKKRFPRVATVPGLLSEVEDDNCNSVSSDAPSSVSQERMIIVGNQLPLRVHQNTDDEGWCFSWDEDSLLLQLKDGLGEDVEVIYVGCLKEEVPPNEQDDVAQTLLETFKCVPAFLPPELFTKFYHGFCKQHLWPLFHYMLPLSPDLGGRFDRSLWQAYVSVNKIFADKVMEVINPDDDYVWVHDYHLMVLPTFLRKRFNRVKLGFFLHSPFPSSEIYRTLPVREELLRALLNSDLIGFHTFDYARHFLTCCSRMLGLSYQSKRGYIGLEYYGRTVSIKILPVGIHIGQLQSVLNLPETESKVAELRNKFRGQTVMLGVDDMDIFKGISLKLLAMEQLLMQHTENAGQVVLVQIANPARGRGRDVEEVRSEAYATVKRINNAFGRPGYDPVVLIDTPLQFYERIAYYVIAECCLVTAVRDGMNLIPYEYIICRQGNEKLDQTLGLNPLGPKRSMLVVSEFIGCSPSLSGAIRVNPWNIDAVADAMDSALILSEAEKQLRHEKHYRYVSTHDVAYWARSFLQDLERACRDHLRKRCWGIGFGLGFRVVAMDPNFRKLSVEHIVAAYKRTKNRAILLDYDSTLLLTSSLSTIPNVEAVGILNNLCRDPKNVVFLVSAKDRKTLTEWFSCCEKLGIAAENGYFIRPKHDADWETCISVPDFDWKQIAEPVMKLYTETTDGSAIETKESSLVWNYRDADPDFGFCQAKELLDHLESVLANEPVLVKSGQHIVEVKPQGVNKGLVAEHLLVTMKQKGMLPDFVLCIGDDRSDEDMFEVIMRATAGPYLSPVADVFACTVGQKCSKAKYYVEDRTEILRMFQVLANASEHASKIAPRPSNRAIIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3F3</accession>
    <name>A0A0D2S3F3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_012G149900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3F3"/>
    <dbReference type="STRING" id="29730.A0A0D2S3F3"/>
    <dbReference type="Gramene" id="KJB77651">
        <property type="protein sequence ID" value="KJB77651"/>
        <property type="gene ID" value="B456_012G149900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77652">
        <property type="protein sequence ID" value="KJB77652"/>
        <property type="gene ID" value="B456_012G149900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000309">
        <property type="entry name" value="E3 ubiquitin-protein ligase MBR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF224">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MBR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="670"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="101"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB77652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="717" mass="77467" checksum="D3FB7D70660AB0A9" modified="2015-04-29" version="1">MQRQGGTINSFPETVNIDMGSSPDNTSIGQPNSLGNMLNPVETRLSNYMVSSGGTTNGNTFTPDVRIFSGWNSGEPSSRLRTQNQVFQDVLNHHLDDDDGTKIEHGWSSSYGAAGDAPRSEERQIEPPNVFFPGRLNNGRSGNQIRSGPLYLQGSSSTHSPQNMNLTEGFTSHRGNGGSSVGTGIGSVGLEREQVSNASVFSGNVGSSSGSGEENDDGSGSSLGSWGLSCKRKAVEGTSEQSYSASTSGNSQQIENVAWHTVPARNDASSRLSLSTLSRNFLDVSPPDQLNSRVGLGMRIVNDAFPSSSTRSANQESQQESLPYSLSSTGVAGPSSFGSPTHPRAAAFGDSLNLRSAAAIAGNSSSPSTQSHMRTISVVPRNAHPFPWTSISSSRTSHPSGSINPLERATALQEEPNERNIPRNNAEHPMFVPATQDPTGWSLASENISMSGGVPSSNRPGPRSTIQLLSPAWIPPCNPPVHYQQRVSEVAPWSLFPPFDSEPGGSSGRFPSLSSAPSASSWETAVSSLSNSQGNNQTYRRSAFIAERQGDDALGRPHSLRSLAADIEGRHRLISEIREVLNAMRRGENLRIEDHMLFDPFIYHGMVETHDRHRDMRLDVDNMSYEELLALGERIGDVSTGLNEETILELMKQRKYSSTTTESTQEPEPCCICQEEYEDGDNTGILNCGHDFHTNCIKHWLMLKNLCPICKTTGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S651</accession>
    <name>A0A0D2S651_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_006G193300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S651"/>
    <dbReference type="STRING" id="29730.A0A0D2S651"/>
    <dbReference type="Gramene" id="KJB37176">
        <property type="protein sequence ID" value="KJB37176"/>
        <property type="gene ID" value="B456_006G193300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800070"/>
    <dbReference type="eggNOG" id="KOG0659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VMRQASH"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000289">
        <property type="entry name" value="Cyclin-dependent kinase D-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000097">
        <property type="entry name" value="Putative cyclin-dependent kinase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF554">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE D-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="11"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="293"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="17"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB37176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="410" mass="46367" checksum="E05D98EB37F26C5C" modified="2015-04-29" version="1">MDPSKKVADRYLKREILGEGTYGVVYKAIDTKTGQTVAIKKIRLGKQKEGVNFTALREIKLLKELKDPNIIALIDAFPHKGNLHLVFEFMETDLEAVIRDRNIFLSPADIKSYTQMTLKGLAFCHKKWVLHRDMKPNNLLIGSNGQLKLADFGLARIFGSPDRKFTHQVFARWYRAPELLFGTKQYGAGVDVWAAACIFAELLLRRPFLQGTSDIDQLGKIFAAFGTPTPSQWPDMVYLPDYVEYQYVPAPPLRSLFPMASDDALDLLSKMFTYDPKARITVQQALEHRYFSSAPLPTDPAKLPRPTPKSRPSDFNPQEGPTVLSPPRKSRRVMPDRDRFEGNSNLLEKIDDHVGEARLAVGDHAGKSDQVPMSVDFSIFGSKPLSRPTINSADRSHLKRKLDLEFQHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S6X7</accession>
    <name>A0A0D2S6X7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G045800</name>
        <name evidence="9" type="ORF">Gorai_017952</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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            <authorList>
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                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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    </evidence>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">8</strain>
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    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    <sequence length="319" mass="37164" checksum="A8263BB81D5AC05E" modified="2015-04-29" version="1">MDSSSSSMNHTISLEELKLFHTIDRAIFSRLVWNLQRQPFESMHVMALFLWLENYSCTPGLHLVYNIHPWSDPLINALADEAVQCLICLNTDEFPFSHFHDDKCTIPLIRKLTGNEISLRFFHENRVEIVRRITQLVRDICLRAFDDIMKLIHDPLIMPVYSEKKMGNQQNLKPNLGFLIGAQRNNEMEDLWKGIHNINIKSLEENNGKKKENKQVEADDRTVFLTFSKGYSVSEAEVRDFFTRKFGKIFEGIEMQEVVEGEQPLYAKLVVKYGSDIEMILNGKQKAKFSINGKHVWARKYVRKNHKSSPSKVESHHLQ</sequence>
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    <accession>A0A0D2S7F5</accession>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7F5"/>
    <dbReference type="STRING" id="29730.A0A0D2S7F5"/>
    <dbReference type="Gramene" id="KJB27215">
        <property type="protein sequence ID" value="KJB27215"/>
        <property type="gene ID" value="B456_004G285200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZQP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWNLNSE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF215">
        <property type="entry name" value="OS02G0781300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="48"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB27215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="232" mass="25728" checksum="BB6C26A3B0C51B49" modified="2015-04-29" version="1">MGCHVAFPITALRLRKSKSYAPHLCLTEHSPVKQNTGRKPESERPDSRFKGARKRKWGKWVSEIRLPNSRERIWLGSYDTAEQAARAFDAALFCLRGRSAKFNFPDNPPDIAGGGSLTHAEIQAVAARFANSAPPRTHAEEQSTSGFQTESPSPSVSVETVRVDGELPVDDGSFLDDLIMGSGHYDSGYGLFPEFDDFSSDFTGLLSVPNIDCEEDDNLAWNLNSEPFLWNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S875</accession>
    <name>A0A0D2S875_GOSRA</name>
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        <recommendedName>
            <fullName evidence="13">DNA polymerase eta</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_009G257800</name>
        <name evidence="18" type="ORF">Gorai_012715</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S875"/>
    <dbReference type="STRING" id="29730.A0A0D2S875"/>
    <dbReference type="Gramene" id="KJB59468">
        <property type="protein sequence ID" value="KJB59468"/>
        <property type="gene ID" value="B456_009G257800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770345"/>
    <dbReference type="eggNOG" id="KOG2095">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5723at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000006">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000029">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000003">
        <property type="entry name" value="DNA polymerase eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000014">
        <property type="entry name" value="Polymerase (DNA directed), eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
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        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21704">
        <property type="entry name" value="POLH-Rev1_HhH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036603">
        <property type="entry name" value="DPol_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="16">
        <location>
            <begin position="14"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="615"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00044975"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB59468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0595866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="680" mass="75959" checksum="6A719F1928E2A26A" modified="2015-04-29" version="1">MPVAKPESSDSRVIAHVDMDCFYVQVEQRKQPQLRGLPTAVVQYNEWKGGALIAVSYEARKFGVKRSMRGEEAKEVCPQVQLVQVPVARGKADLSGYRNAGSEVVSILARRGRCERASIDEVYLDLTDAAEMMLADNPPQGMETIDEEALKSHILGLNNEDGNDVKENVRKWIHRHNADHRDKLLACGILIVAELRMQVLKETEFTCSAGIAHNKMLAKLASGMNKPAQQTVVPFSSVKGLLDTLPIRKMKQLGGKLGISLQMDMGVNTVGDLLQFPEEKLQERYGINTGTWLWNIARGISGEEVEGRLLPKSHGSGKTFPGPRALKTVPAVQHWLNQLCEELSERLCSDLDQNKRIAHTLTLHARAYKSSDSDSQKKFPSKSCPLRYGTAKIQEDAFNLFQAGLREYIGFYGGKTQGSHCSGWGITSLSVSASKIVPIPSGTCSIAKYFQGQSTSHFSSMQSSDNLNTEATLSLPSGSECYSEVNLSEPKIDFPKEESWIKDTVPDLDLQEQKDLSSPLSEKTQDGFIQEDISPLLLSGCLEQNRSKQQRDLTKDESQFKSEYKERKGKRLKDKGTYSIIELFKSYNPNPSGSFLSHEYNRTVGGTDASSSSYSRDEEEGRREAWGYNIDEIDPSVMEELPTEIQDEIKAWMQPHKRRPNNMVKRSCTISHYFSPSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S8U8</accession>
    <name>A0A0D2S8U8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Protein SUPPRESSOR OF VAR 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_006G241400</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer; in free form. Component of the mitochondrial degradosome (mtEXO) complex which is a heteropentamer containing 2 copies of SUPV3L1 and 3 copies of PNPT1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion matrix</location>
            <location evidence="4">Mitochondrion nucleoid</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the DExH box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S8U8"/>
    <dbReference type="STRING" id="29730.A0A0D2S8U8"/>
    <dbReference type="Gramene" id="KJB38186">
        <property type="protein sequence ID" value="KJB38186"/>
        <property type="gene ID" value="B456_006G241400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800536"/>
    <dbReference type="eggNOG" id="KOG0953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPANWYT"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009561">
        <property type="term" value="P:megagametogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009555">
        <property type="term" value="P:pollen development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010929">
        <property type="term" value="P:positive regulation of auxin mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080038">
        <property type="term" value="P:positive regulation of cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009939">
        <property type="term" value="P:positive regulation of gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901002">
        <property type="term" value="P:positive regulation of response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902584">
        <property type="term" value="P:positive regulation of response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.40:FF:000002">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001109">
        <property type="entry name" value="ATP-dependent RNA helicase suv3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1080:FF:000003">
        <property type="entry name" value="DExH-box ATP-dependent RNA helicase DExH16 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Wendel J.F."/>
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                <person name="Conover J.L."/>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN (LEA) FAMILY PROTEIN"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB28850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="338" mass="37152" checksum="BA55E909E3600E40" modified="2015-04-29" version="1">MASSWFFIVFLVLTAASVRCTTVDHMPSTDEDARDYSKLKTKTEEATDEHHSRTQQAKDELKSKADHAANEVKSNTQQAKDRASEVEKEAKEYTESWTEWAKEKISEGLGFKQDDDPKGSVEKASDSVADTATKTKDKLQDMASGAGEYSAGKAKDMKDTAYKKTDDVKNAAKGKSSEMRQATTEKARELADSAKENANTAYIAAKEKVRDMADRTSEMTNEAQERAARKAEEAKEVAAEKAKGAAEETKKKNEETGESLKWAKEKAKQGYDATTEKAKETAKQGYDAAKSKAGETIESAKDTIASGYESAKQKSQELKDNYVNGGGQGRGRERDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SCK7</accession>
    <name>A0A0D2SCK7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G017500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SCK7"/>
    <dbReference type="STRING" id="29730.A0A0D2SCK7"/>
    <dbReference type="Gramene" id="KJB39511">
        <property type="protein sequence ID" value="KJB39511"/>
        <property type="gene ID" value="B456_007G017500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801855"/>
    <dbReference type="eggNOG" id="ENOG502QS98">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFEAKEH"/>
    <dbReference type="OrthoDB" id="737278at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000002">
        <property type="entry name" value="Nac domain-containing protein 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF216">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="NAC" evidence="13">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB39511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="525" mass="58544" checksum="77B9112326AA8FF5" modified="2015-04-29" version="1">MAVISLNSLPIGIRFRPTDEELIDFYLRAKVNGKRKDEIGVIREVDVCKCEPWDLPHLSAVKGRDPEWFFFCPLDRKYPNGNRLNRATEAGYWKATGKDRKIKSGSCLIGMKKTLVFYTGRAPKGKRTNWVMHEYRTTLDELDGTKPGQNPFVICRLFKKQDVTIEDINADDVDPGASSHTEEVQSEFDGPSVEGGAGKVPDETRPVGLCNEAVAPIFDCNNGGFNACELEEMAPAQVDLLGEALVQFCDPMMEPLDWKLFSPLHSQIEAEGAPWMFDHVGNSFGGVKFEHGTNENDAEFMNSILNNLDDYYSDDSSSRRNSVIETETPKSMAFGTNGGLYCKPDAEPAQVLLGTGTANGGAFYNVLNSNGEPSNHVNTACNVDTAPTIRIRSRAHRIQPDTENFDTQGIASRRCKLVVHSPRFEAKEHDSKPILPKGVKAMEEYISVDSDAARRTMDEPQIFETSKRDVSRLKSKVPVSEAVSYRCLKRFSARRQHKPFSVIMFRVVAVMLILFVALVSTLNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SD88</accession>
    <name>A0A0D2SD88_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G128700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SD88"/>
    <dbReference type="STRING" id="29730.A0A0D2SD88"/>
    <dbReference type="Gramene" id="KJB81088">
        <property type="protein sequence ID" value="KJB81088"/>
        <property type="gene ID" value="B456_013G128700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB81089">
        <property type="protein sequence ID" value="KJB81089"/>
        <property type="gene ID" value="B456_013G128700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB81090">
        <property type="protein sequence ID" value="KJB81090"/>
        <property type="gene ID" value="B456_013G128700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB81092">
        <property type="protein sequence ID" value="KJB81092"/>
        <property type="gene ID" value="B456_013G128700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB81093">
        <property type="protein sequence ID" value="KJB81093"/>
        <property type="gene ID" value="B456_013G128700"/>
    </dbReference>
    <dbReference type="OMA" id="EGMEECS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032795">
        <property type="entry name" value="DUF3741-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P DOWN SYNDROME CRITICAL REGION PROTEIN 5 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21726:SF57">
        <property type="entry name" value="SERINE-RICH ADHESIN FOR PLATELETS-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14383">
        <property type="entry name" value="VARLMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="3">
        <location>
            <begin position="75"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="2">
        <location>
            <begin position="769"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB81092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="919" mass="102760" checksum="0FBF518717F0D33B" modified="2015-04-29" version="1">MEVERKHSKGGFFHLFDWNGKSQKKLFPNSAEISEESKRVKPVENILKSPPYMMEGDEYNAASSYRRSADFSSASSVASDEGYGSRAPGVVARLMGLDSLPAPNVLEPSSTTYSGSCSLRVSHYERSSPNLWNESQPMDYTDFSNKLDSLSSNPIEPRFHKVQNRPIERFQTEILPLKSAKPIPITQHKLLSPIKSPGFIPTKNAAYIMEAASKIIEVSPQKTSKHKVPSFGLSSVPLQIWDLKDRIEAAHKVSGHQRPDEPKVSGQQRPDEPIRSTEMSLKGQHKSKSHNKSDYAPTFSISRDSEKGSSNNSRNKGKSVSLAEQARVNNVQRKEGSFSSGNGSSANLKEGNDAKRKQFCRSQADMRKSMENGTSANRTNKVLRRNNQKQNCISNRDYSIPKTSTLDQQGRKTRSINGTVGLNRTINKVIVNSESQSRKTSSSATDPSKEVSMSRRKNLPRKKQPVNEDVLSGETISENTSIKSTQRSIKCNVTTEEHSNQSAEKMKTSMDVVSFTFTSPIARSVPDVPSTSQVVETSCSFDNDPCGNNDLLFSKSSGFSSLGLNIIGGDDLSVLLGKKLQELAYRVESSNCNIIMEETSSRPTSSWQNSVLPSGTLIPTSMRHHKGLQLDLDKDISYSTADFNCSSINHLELDWRRKWQFSEEIEDRNASKSSSKTGTELDHQQSSPLSTLELAVTSECFADDRDGMKQELLDRNQELLGSQPGSESETEFDVALSDFASPKTVGEMDKKLPTRTPNSRDLKESTNWELDYVKMVLKDSELKLMEYALGQTENILTLNGFDQLEHRNITQTQGEEYKKLEQKLVVDCVSEYLEFVVGSCKGWGKLMQNKGRLAEEVYKEIMSLKQMGDIMVDEVVDKDMSRKHGRWVEFETEAFEEGLEIEKTISTCLVDELVFDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDK3</accession>
    <name>A0A0D2SDK3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G151600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDK3"/>
    <dbReference type="STRING" id="29730.A0A0D2SDK3"/>
    <dbReference type="Gramene" id="KJB42369">
        <property type="protein sequence ID" value="KJB42369"/>
        <property type="gene ID" value="B456_007G151600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RRAA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47818:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47818">
        <property type="entry name" value="RNI-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="604" mass="66933" checksum="FA3A60B0539A7225" modified="2015-04-29" version="1">MVNVPSLVSLSIDALKRELIHGDDLLPHVYELPLELFNSLVECLPPLALQKLQSEMPFKNYDDYGPSSDDLKMGRKRGRYGNFDTAWKALFKFRWPDLAECVKPVDWQQIYWETHVQNCLDEAAEIALLPSFSGCLGEIQILENILQYIGYVDDMSNLASDYLKLSYHCQQFGCYSRRLRLQNVLCVLESCQLLRKSNLQSLVVQWIRSSEHVAGLCKLLNQNSRTLTSLEFVHCKISSSFMDTICGSLCSSGAETHQIHHFSISSSSFHEIDPVSLAHSLASFLSSGRSLRSLKLCDNNLDRNFAKSVFSTLLDSSCSLTSFDLSENNISGWLSIFNWKSNTFLSSSGVTKSLQSLRILKLGGNNLQKDDAGNLRYVLVQMPSLEILDLSDNPIEDDGIRSLIPYFAEASKSCSPLTDLNLGSCELSSDGVILLLDVLSTLARPLNSLSLADNGLGSQVAEALGKFWGTSIQVLNLEGIGLGPSGFRKLRDIRMENLKLVKLNISKNRGGIETAKFLSKLILHAPKLVAVNAAYNLMPAESLPLICSALKTAKGLVEQVDLRGNICEYQPSHDTMLAEFQHNGKPILILPSSVALNIPYDDDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SFB0</accession>
    <name>A0A0D2SFB0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G223500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SFB0"/>
    <dbReference type="Gramene" id="KJB81872">
        <property type="protein sequence ID" value="KJB81872"/>
        <property type="gene ID" value="B456_013G223500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB81872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="118" mass="13456" checksum="001A63D85F0ADA5B" modified="2015-04-29" version="1">MPSCLYPTYITRAVGFADSTSKRLPDLRSDRHISFCNKFRATKQSTPSLPWGESLVEASNHRELVLLHGFRGFKGIVSFSNSRVVSQLFLAELFFSSLKGKKRKTREICINVLFIDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHY6</accession>
    <name>A0A0D2SHY6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G159800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHY6"/>
    <dbReference type="STRING" id="29730.A0A0D2SHY6"/>
    <dbReference type="Gramene" id="KJB30770">
        <property type="protein sequence ID" value="KJB30770"/>
        <property type="gene ID" value="B456_005G159800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03564">
        <property type="entry name" value="ANTH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000005">
        <property type="entry name" value="Clathrin assembly protein AP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000003">
        <property type="entry name" value="Putative clathrin assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048050">
        <property type="entry name" value="ANTH_N_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF89">
        <property type="entry name" value="OS05G0549000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0168">Coated pit</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ENTH" evidence="11">
        <location>
            <begin position="24"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="324"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="592" mass="65733" checksum="A721DF164D7937AC" modified="2015-04-29" version="1">MATLQTWRKAYGALKDTTKVGLAHVNSDYADLDVAVVKATNHVECPPKERHLRKIFIATSAIRPRADVAYCIHALGRRLTKTHNWTVALKTLIVIHRALREGDPTFREELLNFSQRARILQLSNFKDDSSPIAWDCSAWVRTYALFLEERLECFRILKYDIEAERLPRPDQGQDKGYSRTRELDSEELLTQLPALQQLLHRLIGCRPEGAAIGNYVIQYALALVLKESFKIYCAINDGIINLVDKFFEMPRHEAVNALDVYKRAGQQANSLSDFYEVCKGLELARNFQFPVLREPPQSFLATMEEYIREAPRVVSVPTEPLLQLTYRPEEGPSEDSKLPNDEPEPSAPADDNDAASTVETAPPPPPPTQTNMDTGDLLVMFLLEFHNGILFVYFIFFIVYWWVQGLNYSAPDASAIEESNALALAIVPTESGTASTFNSSAGQPVEFDPTGWELALVTTPSTDISAPTDRQLAGGLDSLTLNSLYDEAAYRAQHPAYGTPAPNPFDAQDPFAMSNNVAPPPAVQMAAMAQQQNNPFGAYQPAYQQPQQQQQQLMMSPSNPFGDTGFGAFPVNQVAPVGQPHANNPFGSTGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJW3</accession>
    <name>A0A0D2SJW3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G145300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJW3"/>
    <dbReference type="STRING" id="29730.A0A0D2SJW3"/>
    <dbReference type="Gramene" id="KJB42256">
        <property type="protein sequence ID" value="KJB42256"/>
        <property type="gene ID" value="B456_007G145300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803193"/>
    <dbReference type="eggNOG" id="KOG1840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMEGNVA"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47459">
        <property type="entry name" value="KINESIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47459:SF1">
        <property type="entry name" value="KINESIN LIGHT CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="209"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="413"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="610"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB42256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="633" mass="70557" checksum="106E4617231560C7" modified="2015-04-29" version="1">MKKASLSLISKLNRQRFRGISPLLSRDYISVNSPSSSSPSPLHSRDHRIQFCAKTPGLVYPCRNLGTLVEKPNQLPSRQRKLKEKSDLEEAFESAKTSEEMLRAFKDMEACFDERELGLASLKIGLKLDQEGEDPEKALSFADKALKALDQDGKPSILVAMALQLMGSVNYSLKRFNDSLGYLNRANKLLGRLEEERVASVEDIRPVMHAVQLELGNVKTAMGRREEALGNFKKALEIKEITLEKDCKELGVAYRDLAEAYASVLNFKEALPFGLKALEIHRKELGNNSVEVAHDRRILGVIYTGMEEHEKALEQNELSQKILKNWGLSSELLRSEIDAANMQIALGKYDEAINTLKGIVQQTDKDSENRALVFISMGKALCNQERFADSKRCLEIACGILDKKETVSPIEVAEAYSEISMQYETMNEFEIAISLLKRSLALLEKQPQEQHSEGSVSARIGWLLLLKGEVPQAIPYLESAAEILKESFGSKHFGVGYIYNNLGAAYLELDRPQSAAQMFAVAKDIMDVSLGPHHVDSIETCQNLSKAYSAMGSYPLAIEFQRRVVDAWEGHGASAEDELREAQHILEELKTKARGTSTNQFPTKALPLPQHSLASRNSHPNVSFNQNSAGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVA5</accession>
    <name>A0A0D2SVA5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G107700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVA5"/>
    <dbReference type="Gramene" id="KJB35275">
        <property type="protein sequence ID" value="KJB35275"/>
        <property type="gene ID" value="B456_006G107700"/>
    </dbReference>
    <dbReference type="OMA" id="VWLNKCN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB35275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="8284" checksum="52DEE173BFEA7A76" modified="2015-04-29" version="1">MNLDGLSLHTYFSLLSVFEQEFTNAGVTLQIDFVSIQHTSPPLYACLLVLPFHNLPNAFPVVWLNKCNFLPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SYV5</accession>
    <name>A0A0D2SYV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G112300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SYV5"/>
    <dbReference type="STRING" id="29730.A0A0D2SYV5"/>
    <dbReference type="Gramene" id="KJB49309">
        <property type="protein sequence ID" value="KJB49309"/>
        <property type="gene ID" value="B456_008G112300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RY5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMRIRYM"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd07245">
        <property type="entry name" value="VOC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46142:SF8">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB49309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="178" mass="20284" checksum="A409310960D30310" modified="2015-04-29" version="1">MQEGKEESGAAAPPLLALNHVSRLCRNVKKSIDFYTKVLGFVLVERPPALDFDGAWLFNYGVGIHLVQSKDDDKLPSDSHHLDPMDNHISFQCEDMEEMEQRLKEFNTEYIKRTMEDESGTKIDQLFFNDPDGFMVEICNCENLKLVPAGSMGRIKLPFDRHNPPLDLDANSNPSYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZA8</accession>
    <name>A0A0D2SZA8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G168400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SZA8"/>
    <dbReference type="STRING" id="29730.A0A0D2SZA8"/>
    <dbReference type="Gramene" id="KJB36643">
        <property type="protein sequence ID" value="KJB36643"/>
        <property type="gene ID" value="B456_006G168400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36644">
        <property type="protein sequence ID" value="KJB36644"/>
        <property type="gene ID" value="B456_006G168400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36645">
        <property type="protein sequence ID" value="KJB36645"/>
        <property type="gene ID" value="B456_006G168400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799807"/>
    <dbReference type="eggNOG" id="ENOG502QUAG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SVHDNEG"/>
    <dbReference type="OrthoDB" id="1923765at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF175">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="4">
        <location>
            <begin position="379"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB36645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="452" mass="50208" checksum="AAE76FF9B53DC0FA" modified="2015-04-29" version="1">MGKKGKWLSSLKKVFSPDSQEKKNQKSKQQLLEKQVHLGSSDSGAATLETVSLSPPPPEEVKPIEAESKQTYPVVVASAAASPQAAVEVVQRQLNRDALFAGKSEEEVAAIKIQTTFRVYLARRALHALKGLVRLKSLMEGPVVKRQAASTLRCMQTLSRLQCQVRIRRTRMTEENQALQRQLLQKHAKEIVNLQMGEDWDYSLQSKEQIEASLLSKHEAAMRRERAMAYSFTHQQTWKNASRSMNPLFMDPNNPSWGWSWLERWMAAQPQEGRGTTEKEQNDQSSIRSARSNFGGEISKAYARYQLNLDKQSPKAGQKPNQTSSLLSVSTPKTSASIPARKLKSASPRSSVVGPDDDGRSMVSIQSERNRRHSIAGSSVHDNEGLGSSPLLPSYMVPTESTRAKTQLQSPLGLEANGTPRKGPIASAKKRLSYPPSPARPRQHLLIQKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T4H0</accession>
    <name>A0A0D2T4H0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_008G215400</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T4H0"/>
    <dbReference type="Gramene" id="KJB51409">
        <property type="protein sequence ID" value="KJB51409"/>
        <property type="gene ID" value="B456_008G215400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764887"/>
    <dbReference type="eggNOG" id="ENOG502QSRW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905393">
        <property type="term" value="P:plant organ formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009791">
        <property type="term" value="P:post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000909">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000632">
        <property type="entry name" value="leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000292">
        <property type="entry name" value="Leucine-rich repeat receptor-like serine/threonine-protein kinase BAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF25">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="669"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="729"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB51409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1043" mass="114633" checksum="8012F3E4522D6F85" modified="2015-04-29" version="1">MSFTSLFHITMKKPPFLPSLLPFFLYLLTSSLLVFSASASPPPLPLVSLLSLKSSLKDPLSSFGDWDPTPTFSKPSFEDPVWCAWSGVKCNPKTAQVTSLDLSRRNLSGVIPPEIRYLTGLVNLNLSGNYFDGPLQPAIFKLSELRTLDISHNSFNSTFPPGVSKLRFLKVFNAYSNNFRGPLPQEFVRLRFLEQLNLGGSYFEGEIPAGYGSFTRLKLLDLAGNALQGTLPRQLGFLTQLERIEIGYNAFSGTIPVEFALLPNLKYLDISNCTLSGSLPKELSNLTKLEVLYFFKNSFTGEIPESYTKLKALKVLDLSDNQLSGTIPEGLSSLTELTWLSLINNNLSGTIPEGIGELTNLSTLLLWNNNLSGILPQKLGSNGKLLSLDVSSNSLTGPIPPNLCYGNRLFKLILFNNMFTHELPASLVNCTSLSRFRIQNNLLNGTIPYGFGLLTNLTFVDMSKNNFTGEIPHDLGYAPTLQFLNISENSFNVALPSNIWGAPSLQIFSASSAKLTGKIPDFIGCKNVYKIELQGNSLNGSIPWDIDHCEKLLSLNLSRNLFTGIIPWEISTLPSITAVDLSRNMLTGTIPSNFENCSTLENFNVSYNLLTGPIPSSGPIFPNLHPSSFSGNDGLCGRILAKPCPAEALASGDMEVRNKQQQPKKTAGAIVWIMAAAFGIGLFVLVAGTRCFHANYSRRFSDDREIGPWRLTAFQRLNFTADDVLECLSMTDKIIGMGSTGTVYKAEMPGGEIIAVKKLWGKHKDNIRRRKGVLAEVDVLGNVRHRNIVRLLGCCSNRECTMLLYEYMPNGNLDDLLHGKNKGENLVADWVTRYKIALGVAQGICYLHHDCDPVIVHRDLKPSNILLDGEMEARVADFGVAKLIQSDESMSVIAGSYGYIAPEYAYTLQVDEKSDIYSFGVVLMEILSGKKSVDSEFGDGNSIVDWVRSKIKNKNGVIDILDKNAGASCASVREEMMQMLRIALLCTSRNPADRPSMRDVVLMLQEAKPKRKMLESVVNGGNVVRVGADGTDDSLAQKATVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7E4</accession>
    <name>A0A0D2T7E4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kazal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G017600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T7E4"/>
    <dbReference type="STRING" id="29730.A0A0D2T7E4"/>
    <dbReference type="Gramene" id="KJB39515">
        <property type="protein sequence ID" value="KJB39515"/>
        <property type="gene ID" value="B456_007G017600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801859"/>
    <dbReference type="eggNOG" id="ENOG502S3PN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKSGICE"/>
    <dbReference type="OrthoDB" id="1916993at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, KAZAL-TYPE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34376:SF2">
        <property type="entry name" value="SERINE PROTEASE INHIBITOR, KAZAL-TYPE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267699" description="Kazal-like domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB39515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14475" checksum="14588AB186A66221" modified="2015-04-29" version="1">MVTLFSIQFHEPSLTLLLLLLLLVVPFSSSLTVGSQRNFTTTAILLPSESADACGSSPRPYSCPVNCFRTDPVCGDDGVTYWCGCADAHCSGAKVAKIGFCNVGNNGGTGSFPGQALLLLHIVWLIVLGFSVFFGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TAH2</accession>
    <name>A0A0D2TAH2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">(+)-abscisic acid 8'-hydroxylase</fullName>
            <ecNumber evidence="14">1.14.14.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_008G218900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-cis-(+)-abscisate + reduced [NADPH--hemoprotein reductase] + O2 = (+)-8'-hydroxyabscisate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12897"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:37569"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58490"/>
            <dbReference type="EC" id="1.14.14.137"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Plant hormone degradation; abscisic acid degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.137" evidence="14"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TAH2"/>
    <dbReference type="STRING" id="29730.A0A0D2TAH2"/>
    <dbReference type="Gramene" id="KJB51491">
        <property type="protein sequence ID" value="KJB51491"/>
        <property type="gene ID" value="B456_008G218900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764928"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MRVICEL"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010295">
        <property type="term" value="F:(+)-abscisic acid 8'-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009687">
        <property type="term" value="P:abscisic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000014">
        <property type="entry name" value="Abscisic acid 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF10">
        <property type="entry name" value="ABSCISIC ACID 8'-HYDROXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00060633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00066338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="463" mass="52974" checksum="0FE718379C844621" modified="2015-04-29" version="1">MAFTFIFCFIPPFLFIFLFHSLLLHFFKPNRPKLPLPPGTMGWPYIGETFHLYSQNPNVFFASKQKRYGSIFKTHILGCPCVMISSPDAAKFVLVTKSHLFKPTFPASKERMLGKQAIFFNQGPYHAKLRKLVLRAFMPDSIKNIVPNIESIAKHSLHSLQGRLITTFQEMKTYTFNVALLSIFGKDDQVLYREDLKRCYYILEKGYNSMPINLPGTLFNKSMKARKEIAQILAKIISTRRQTKQVDCNDLLGSFMSDKEGLTDEQIADNVISVIFAARDTTASVLTWIIKYLGENPSVLQAVTEEQEAIMRGKEEQELSWEDTKKMPLTSRVIQETLRVASILSFTFREAVEDVEYEGYLIPKGWKVLPLFRNIHHSPEIFPDPQKFDPSRFEVAPKPNTFMPFGSGTHSCPGNELAKLEIMVLLHHLTTKYRWSMVGSNSGIQYGPFALPQNGLPIRLVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TK06</accession>
    <name>A0A0D2TK06_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G150900</name>
        <name evidence="17" type="ORF">Gorai_011913</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the targeting and/or fusion of transport vesicles to their target membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Early endosome membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TK06"/>
    <dbReference type="STRING" id="29730.A0A0D2TK06"/>
    <dbReference type="Gramene" id="KJB57019">
        <property type="protein sequence ID" value="KJB57019"/>
        <property type="gene ID" value="B456_009G150900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770217"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEYCADH"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000010">
        <property type="entry name" value="Vesicle-associated membrane protein 726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000014">
        <property type="entry name" value="vesicle-associated membrane protein 727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF92">
        <property type="entry name" value="LONGIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="14">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB57019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0595032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25071" checksum="C0174DB552A1E424" modified="2015-04-29" version="1">MVHKSLIYAFVSRGEVILAEYTEFSGNFNSIAFQCLQKLPSSNNKFTYNCDGHTFNYLVDNGYTYCVVADELAGRQVPIAFLERVKEDFVSKYGSGKAATAPANSLNKEFGPKLKEHMQYCVEHPEEISKLAKIKSQVSEVKGVMMENIEKVLDRGEKIELLVDKTENLHQQAQDFRNTGTKIRRKMWLQNMKIKLIVLGILIALILIIVLSVCHGFNCGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPG6</accession>
    <name>A0A0D2TPG6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G226400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPG6"/>
    <dbReference type="Gramene" id="KJB58790">
        <property type="protein sequence ID" value="KJB58790"/>
        <property type="gene ID" value="B456_009G226400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58792">
        <property type="protein sequence ID" value="KJB58792"/>
        <property type="gene ID" value="B456_009G226400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58794">
        <property type="protein sequence ID" value="KJB58794"/>
        <property type="gene ID" value="B456_009G226400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770811"/>
    <dbReference type="eggNOG" id="KOG4754">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MELCGVQ"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF13">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB58794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34796" checksum="DAFB3A7153975279" modified="2015-04-29" version="1">MDTIAASPHKILHLVRHAEGVHNLESDKSRDPLTSFEFLDAQLSSLGRQQVVAERKHVRETGLLDEVEVVIVSPMTRTLETAVGIFGGKEQADALDVSSCQDSNVNSNETSAIFNSRPRIVAYELCRERMGILECDKRASISQYRSHFPTVDFSLIENEDDVLWKSDERESYDEIQARTIKFLKWLWERKEQKIAVVSHGIFLQKAMIELVKNNNFYRLPLRGHPIKLERKNWYPLMDDEYTRSRFKNCEIRSIAILHESMMESDAMISKQQYCGRIGKEMLQIRDSSNDKMAVEELEVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTV9</accession>
    <name>A0A0D2TTV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G223600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTV9"/>
    <dbReference type="STRING" id="29730.A0A0D2TTV9"/>
    <dbReference type="Gramene" id="KJB58736">
        <property type="protein sequence ID" value="KJB58736"/>
        <property type="gene ID" value="B456_009G223600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCIGRSN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000104">
        <property type="entry name" value="Endo-1,4-beta-xylanase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000103">
        <property type="entry name" value="Glycosyl hydrolase family 10 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF47">
        <property type="entry name" value="GH10 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="406"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB58736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="765" mass="86084" checksum="E20D0A6B70C1B8BA" modified="2015-04-29" version="1" fragment="single">TFEILLLFSPDIFGTIESVFLPNLPALETNPSFHVFDQSTRKGHIANGSNNIILNPTFENELSNWSGKGCNILLHESMEDGKILPLYGKFFASATNRTRSWNGIEQEITGRVRPKLAYEVTAIVRIYGGNVADANIQATLWVQSQDINEQYIKIAISQATDKGWVQLQGKFLLNGSPLKVIIFLEGPPPGTDILINRLVVKHAEKAPPPLRPFMKNEAFGVNIIENSNLDDGINGWFPLGNCSLNMEFGSPIELPSMARNSLGMQERLSGRYILVTNRADTWMGPAQMISGKLKLYLTYQVSAWVKIGPGSTSPQIVNVALSIDGNWVNGGQVEFNNESWHEVGGSFRIDKQPSNVMVYIQGPAAGVDLMVAGLYIFPVDRRARFKLLKKQTDKIRKRDLILKFSSSKADNVSGAFVKVEQIQNSFPFGSCITRSSIDNEDLVRFLEKNFNWVVFGNELKWSWTEPQQGNFNYKDADELLDFCKNNNLEVRGHCIFWEVEYAIQPWVQGLNKSDLTTAVQNRLTDLVTRYKGKFRHYDVDNEMLHGSFYKDRLGKDIQATMFRTSHQLDPSATLFVNDYHIEDGSDVRSSPEEYIRQILDLQRQGAPVGGIGLQGHIDSPVGPIVSSALDKVGTLGLPIWFTELDVSSANEFIRADDLEVMLREAFAHPAVEGIILWGFWELYMSRENAHLVNAEGKINAAGKRYLALKKEWLSRARGYIDVQGEFRFRGFYGTYNIEINSPTMKINRTFVVDKGESPLAINIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TY47</accession>
    <name>A0A0D2TY47_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Disease resistance RPP13-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G368700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB61594">
        <property type="protein sequence ID" value="KJB61594"/>
        <property type="gene ID" value="B456_009G368700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFICIEN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF51">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="7">
        <location>
            <begin position="15"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="6">
        <location>
            <begin position="188"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="9">
        <location>
            <begin position="695"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB61594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1415" mass="160663" checksum="0EF97936D505ED5C" modified="2015-04-29" version="1">MSVIGEAALSGFLELLWGRLLDSALNFVADHKQVQQQLKQWQSILPDIQAVLNDAEEKQIKNKGVRNWLEDLQDLAYDMDDILDEFAYEELRLALLKTQAQASISKVRKLIPTCCTSSNFSPTSFLFNNSMIPKMKEITARLDSLTTRRNSLGLSEILSQGATSKGKKPRLQPTSVVDEAVEYVGRDDEKRKMLDLLKSNNSNGVFVLSIVGMGGMGKTTLAQLVYNDASTKESFDHRAWVCVSDEFDAVNITKTILQSITSEPCAYNDLNLLQVKLKEKLSGKKFLLVLDDIWNESYEDWTILRSPFGAGTKIIVTTRIQNVSSNVDPVKAFHLDKLSHDDCLSIFTQHALKARNFNGHLQFKEVGENIVRRCNGLPLAAKAIGSLLRTVKDLGEWEKIYESEIWDLPEDQCGILPALRLSYHHLPPQLKRCFAYCSIFPKDYEFQKEEIILLWRAEGFLQLNAKGQIKDPGNQYFQDLASRSFFQISSKDKSRFIMHHLINDLAQSVAGEICCKLEDDKQQMFSNRTRHSSFIVSRYETAKKFEAFDKADSLRTLIALMSPSFPGFFLTNFVLVDLLPRLGYLRLLSLSGYKIIELPDVFENLKHLRYLNFSYTEIKCLPDSLCTLYYLETLILRGCGCLQQLPSKMENLINLHYLDIRGAKSIERMPFGIGKLTNLQRLSNFVIGKGDGHYIGELKNLPNLKGDFCISGLENVNGQHAGEVKLNEKLGIERLVLQWSSNFEKYARNKEAEERVLDSLRPQKKLEQLNIDNYGGAKFSSWIADSSFKNMLSLELCNCTSCKSLPSIGLLPLLKDLSIIGFDEVQKVGAEFFGENQLKPFVSLENLHFQRLPNWKEWDPCEGEEQVSKFPNLRELSIRECPQLLEKLPTRLPSLLKLQIYECPRLTVSISCFPSLCELSVRGCEELLDECSFSAKEVISLKTASLSDISKFNISTKMKMLRFASSEHFHIPGWKELESLSQNGLGLVGHHFITIKDCPQLVSLETDEEGLKLDKIPSVESLTIWNCKRLNRLPKFLDALSFLTVVSIYGCSGLISFAENNFPPALNKLEIWECENLQNLVDEKENNKSMSSNICLLEHLDIRYCKSLICLSSRGDICNRLRHLQVYNCSSLSSLFLNTKLPTMLKQLEIWNCPMLECIAQDFHETSDLECIKISGAQNIKSLPRGLDKLNLLQEIQIVNCSNMVVSFKESELPTTNLRVFSIEGCENFGALPMCINNFISLRELMVWNCSADISFPYEGFPTGLTSLAISNAPKIYSSLVEWGLTRLTSLQQLTIGGEGCSNVVSFPEEGIGMMLPPSLTFICIENFEKLESMYSKGFQHINSLQILSIHNCPKLTSLPEKDMLLSLERLHIYECLLLEKVSTRDKGREWSKIAHIPYVNFKIKKSRLDYQLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZS7</accession>
    <name>A0A0D2TZS7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G119800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZS7"/>
    <dbReference type="STRING" id="29730.A0A0D2TZS7"/>
    <dbReference type="Gramene" id="KJB80883">
        <property type="protein sequence ID" value="KJB80883"/>
        <property type="gene ID" value="B456_013G119800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIGRIFA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48464">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48464:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB80883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="326" mass="37166" checksum="7F7C62CE0328181F" modified="2015-04-29" version="1">MSGVPQSHASSQASRGSKRKWVPEEDAALVSCMVDLHNVGTINADTGFKASYLNELEKMLEKALPRAMLKAKPNIEYWIRCLKREWLVIYDMLNGQNNSGFGWDEHRQLVVAEDTVWESYVKSHKEAAQFRHRSFPYYNQLTAIYARDRVTGKDAQTAADVLEEIHAEDVPTTDMNEERNTFYDCEADVSLDDMDVSGTEPRGDRDQGGSSSSNKRKKKSDARDNVYSSFDEAATLLAENIKAVGDQISRSIASEVVVQQKSEEYQKMEKKASHLYSTLWEIEGLSDDQRYEALTKIPDHPTQMIVFFSLPSVARLEWVRRFLSHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZW1</accession>
    <name>A0A0D2TZW1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MAT1 centre domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G090500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZW1"/>
    <dbReference type="STRING" id="29730.A0A0D2TZW1"/>
    <dbReference type="Gramene" id="KJB48860">
        <property type="protein sequence ID" value="KJB48860"/>
        <property type="gene ID" value="B456_008G090500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763532"/>
    <dbReference type="eggNOG" id="KOG3800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DMLGGEY"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MAT1 centre" evidence="1">
        <location>
            <begin position="10"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB48860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="191" mass="21085" checksum="6FA35E970EB52E2D" modified="2015-04-29" version="1">MVVASSNPHNKEMQIRRRISNIFNKREEDFPSLREYNDYLEEVEDMIFKLIEGIDVQAIEEKITNYQQENAEQIMINQARKAEDLAAAMAASKGIPVQADTDGALSQNSQAGFVAGTQGQYAPTVAGGQPRPTGMAPQPVPLAGGLDMHGYALDDEEMMRLRAERGGRAGGWSIELSKKRALEEAFASIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0D6</accession>
    <name>A0A0D2U0D6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G355700</name>
        <name evidence="12" type="ORF">Gorai_013364</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0D6"/>
    <dbReference type="STRING" id="29730.A0A0D2U0D6"/>
    <dbReference type="Gramene" id="KJB61364">
        <property type="protein sequence ID" value="KJB61364"/>
        <property type="gene ID" value="B456_009G355700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB61365">
        <property type="protein sequence ID" value="KJB61365"/>
        <property type="gene ID" value="B456_009G355700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB61366">
        <property type="protein sequence ID" value="KJB61366"/>
        <property type="gene ID" value="B456_009G355700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766250"/>
    <dbReference type="eggNOG" id="ENOG502R7AV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHAVTNF"/>
    <dbReference type="OrthoDB" id="610645at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF225">
        <property type="entry name" value="AP2 DOMAIN CLASS TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038123">
        <property type="entry name" value="PTI6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="77"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB61366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0596548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="142" mass="15792" checksum="805CCA196FA711BB" modified="2015-04-29" version="1">MSPPQPNGKPQQPISRRIVRITVTDADATDSSSDEEAAPPKKIQKRPKKKLVNEITIGVSTKENDVIAGSSHSKVKRYRGVRQRPWGRWAAEIRDGRRMRLWLGTFDTAEEAAVAYDQAAVKLRGPNAPTNFKLLDCNAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2J9</accession>
    <name>A0A0D2U2J9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G403300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the assembly of mitochondrial iron-sulfur proteins. Probably involved in the binding of an intermediate of Fe/S cluster assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HesB/IscA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2J9"/>
    <dbReference type="SMR" id="A0A0D2U2J9"/>
    <dbReference type="STRING" id="29730.A0A0D2U2J9"/>
    <dbReference type="Gramene" id="KJB62156">
        <property type="protein sequence ID" value="KJB62156"/>
        <property type="gene ID" value="B456_009G403300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766677"/>
    <dbReference type="eggNOG" id="KOG1120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LYIYGMQ"/>
    <dbReference type="OrthoDB" id="333486at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.300.12:FF:000001">
        <property type="entry name" value="Iron-binding protein IscA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.300.12">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016092">
        <property type="entry name" value="ATAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000361">
        <property type="entry name" value="ATAP_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050322">
        <property type="entry name" value="Fe-S_cluster_asmbl/transfer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017870">
        <property type="entry name" value="FeS_cluster_insertion_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035903">
        <property type="entry name" value="HesB-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00049">
        <property type="entry name" value="iron-sulfur cluster assembly accessory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072:SF41">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY 1 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10072">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01521">
        <property type="entry name" value="Fe-S_biosyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89360">
        <property type="entry name" value="HesB-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01152">
        <property type="entry name" value="HESB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core" evidence="3">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00057984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB62156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="137" mass="15092" checksum="8BF1C3767BD23BB8" modified="2015-04-29" version="1">MASRLFATAAEKIGQPALRRQVLTLTDAAASRIHHLLQQRQRSFLRLGVKARGCNGLSYTLNYADEKGKFDELVEDKGVKILIDPKALMHVIGTKMDFVDDKLRSEFIFINPNSKGQCGCGESFMTTTGSTAKQGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2Y1</accession>
    <name>A0A0D2U2Y1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G411800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2Y1"/>
    <dbReference type="Gramene" id="KJB62326">
        <property type="protein sequence ID" value="KJB62326"/>
        <property type="gene ID" value="B456_009G411800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GILINGW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000047">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF229">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 73C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB62326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="463" mass="51655" checksum="B9E207E819EE1DCD" modified="2015-04-29" version="1">MVDIGRLLAQRDVTVTIVTTPYNAGRVQKSVARAIESGLPIRLLQLQFPGKEVGLPDGVENIDMLHSMEDLIKFVSAANKMEEAMLKLFEKLTPRPNCIISDINLFYTRKIATKFQVPRISFHGFCCFCLLCLRNIQSSKINETVTSDSEYFTVPGLTDKVEFTRVQLPLDYDGSWKEIFEPMWEADRASYGVVINTFEELESAYVKEYRKEKKAWCIGPVSLSHKDELDMAERGNKASIDGQKCLKWLDSQQPGSVIYACLGSTGSIKCPELIELGLGLEASNKPFIWVLRGNNPTASEVDKWIKRNGFEERTKGRGLVAVGWAPQVLILSHPAIGGFLTHCGWNSIIEGISAGVPLITLPFMGDQFCNEKLVVQILKIGVNLGANKPTMLGEEKSGFILNKEHVKNAIDKLMDRGNEGTEMRKRAKELGDEANKAVEVGGSSYMNITLLIQDILQQSQEMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U340</accession>
    <name>A0A0D2U340_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL13c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">50S ribosomal protein L13, chloroplastic</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">CL13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G175400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U340"/>
    <dbReference type="STRING" id="29730.A0A0D2U340"/>
    <dbReference type="Gramene" id="KJB82078">
        <property type="protein sequence ID" value="KJB82078"/>
        <property type="gene ID" value="B456_013G175400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783275"/>
    <dbReference type="eggNOG" id="KOG3203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KPWVVID"/>
    <dbReference type="OrthoDB" id="274622at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_uL13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00082726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB82078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="246" mass="27792" checksum="8CCC0308CA9AB161" modified="2015-04-29" version="1">MALLCASTSVIFSSSSSERPSFASLKRTIPSNQSSFLGFFPVVALSKPSSARTTTLSFSKRDFRVCCQDLSLVPENQRWMFEESEADGPDIWNNTWYPKAKDHINTEKTWYIVDAADKILGRLASTIAVHIRGKNLPTYTPSVDMGAFVIVVNAEKVAVSGKKRTQKLYRRHSGRPGGMKVETFNQLQQRIPERIIEHAVRGMLPKGRLGRALFNHLKVYKGADHPHEAQKPIELPIRDKRVQKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3A3</accession>
    <name>A0A0D2U3A3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="11">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G146400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP). TPP is an active cofactor for enzymes involved in glycolysis and energy production. Plant leaves require high levels of TPP for photosynthesis and carbohydrate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:11577"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="11"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3A3"/>
    <dbReference type="STRING" id="29730.A0A0D2U3A3"/>
    <dbReference type="Gramene" id="KJB49945">
        <property type="protein sequence ID" value="KJB49945"/>
        <property type="gene ID" value="B456_008G146400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764126"/>
    <dbReference type="eggNOG" id="KOG3153">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHLYMMT"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10240:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="12">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB49945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="289" mass="32510" checksum="1A19C05926A8D9C6" modified="2015-04-29" version="1">MLRLQSIKLAKAKHLTVPSPSSLRLVKKRMIAMDLMHHSSCFLLPTIPLQRRPSLTYALLVLNQNLPRFTPLLWNHAQLHLCADGGANRLYDEMPLFFPQEGASDVRRRYKPDVIKGDMDSIRREVLEFYASLGTEIVDKSHDQDTTDLHKCVTYIRDSASGLDKSNLCILVVGALGGRFDHEMGNLNVICRFSYMRIVLLSNDSLIHLLPRTYCHEIHIQTSVEGPHCGLIPIGTPSKSSTTTGLQWDLNNTAMEFGGLVSTSNIVKEEKVTVQSDCDLLWTISIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5V6</accession>
    <name>A0A0D2U5V6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G232300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5V6"/>
    <dbReference type="Gramene" id="KJB83163">
        <property type="protein sequence ID" value="KJB83163"/>
        <property type="gene ID" value="B456_013G232300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQAVIPT"/>
    <dbReference type="OrthoDB" id="2018467at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF67">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="170"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="7">
        <location>
            <begin position="429"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="8">
        <location>
            <begin position="561"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB83163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="96096" checksum="85B5428A7A1A29EF" modified="2015-04-29" version="1">MAETFLFNIAERVLEKLVHLSVQEIRLAFNVKTELETLEDTMSNIKAVLLDAERQQHHNEKLHLCMWKLRDIFYDAEDVIDDFKCEALRKQDAINHPDINNLKVRVLGSCCLPLSFSLKLSHKVKDINRRLGELATEWNSFALSQCNDSRHVFPRETISFVDSSDVIGRDEDKKNIISMLMKPSEDRNVPVIPIVAIGGLGKTTLAQLVYNDDRVNSLFPLKIWICVSEEFDLSRLLKLIIQSVNPEVICDDLTLEALQARLRSLLNDKKFLLVLDDVWNENQAKWVELRNLLRSTDGFLSSKIIVTTRSLNVASIMSSIPPYILKGLSLEDCLTLFIKWAFNDGNERHYPNLLRIGEEIVKKCKGVPLAVRTLGSLLFQKTDESDWIYIRENEIWRLQQNENDILPVLKLSYNHLPSHLQRCLAFLSLYKKDEIYYSDKVIRLWMANGLLEYPNQNQEWEDVGKRYLNELLSRCLIQKEKDFCLYFTFTMHDLVHDLALDVSQKECKIVNPETKMVDEHVRHLLLCDEKLVEVPCVLGEMKNVKTVVIQDASKESKTIHESLINLCVSNFKYLRALELRDSPLRALPNSIGTLKHLRDLDLAKCEGIHELPRSFYKLRSLQSLNLGGTGLKQLPDSVQRLIEIRHLEITVKAKRLKEIQAGCWTSLQYLKLHSCSKLECLPDGMQYLKSLRTLVLVGCARLVFLPRSLKFLSKLENLKITSCRRINLKMEPEEKEDDLQLSLKTFSLFRLDTLRDLPRLLLQGSSSTLQQIEITWCQQLSFLPAWLLNLTSLQELRIGGCKNLSALPEGIGRLTNLRQLTTVGCPVEQKIQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8Z6</accession>
    <name>A0A0D2U8Z6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Growth-regulating factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G241800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8Z6"/>
    <dbReference type="STRING" id="29730.A0A0D2U8Z6"/>
    <dbReference type="Gramene" id="KJB52005">
        <property type="protein sequence ID" value="KJB52005"/>
        <property type="gene ID" value="B456_008G241800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZPC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031137">
        <property type="entry name" value="GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014977">
        <property type="entry name" value="WRC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602:SF81">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08879">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51667">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="QLQ" evidence="8">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="WRC" evidence="9">
        <location>
            <begin position="154"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="267" mass="29276" checksum="D8034B5D5D3F7537" modified="2015-04-29" version="1">MEPQYTPLKIARFADFGTLFFLYSLSLDYHALVNLLFSFFAGIGLTNMESNMLSSGEGSPPIGLGLELGRGSDHRPTGFTKSCGFTVFQLQELQLQSLIFKYMEAGLPVPNHLLLPIWKSVAGSLGGLHANPYQLYSSYLGCGPLHLEYKNGVDPEPGRCRRTDGKKWRCSKEAVPDHKYCERHMHRGRQRSRKLVEASQATSSGSRIISNGNADTNLSISLQLDNSNTSSSGSSSNLSSGFIGFSPKSVLRGSNPKSESSIQFQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UBI1</accession>
    <name>A0A0D2UBI1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_010G092000</name>
        <name evidence="14" type="ORF">Gorai_007470</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UBI1"/>
    <dbReference type="STRING" id="29730.A0A0D2UBI1"/>
    <dbReference type="Gramene" id="KJB65361">
        <property type="protein sequence ID" value="KJB65361"/>
        <property type="gene ID" value="B456_010G092000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQIFCES"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138">
        <property type="entry name" value="OS01G0690200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138:SF78">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE GALACTURONAN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989185" description="non-specific serine/threonine protein kinase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="11">
        <location>
            <begin position="30"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase C-terminal" evidence="12">
        <location>
            <begin position="194"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB65361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0597670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="282" mass="32065" checksum="0E9C03994A9F2339" modified="2015-04-29" version="1">MLNPIPTVIFFTLHILLIQSQTHTSNHSRCPPFRCHHIDFPFPFSDQRTFGSGTIDCGFPGYQILCDEEEEEEEESTPVPILMISTQPYQVKNIFLNQFYDEGVVNLITLVNTDLIRDINTASCHSFRNFTSPISGLLLPDWNINLTFFKCPSQFAPPQDFLDQTALNYTCNDEQSWLYLGRYVNSSPMNRTERSFNNSITPRDCNLVMLPVSSADINVSSVNNGDIERSQLSKVLAAGFPLQWKSDVDCENCIKKKERCGFDRTKVVCLCDDDCNNTNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFL2</accession>
    <name>A0A0D2UFL2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myosin-17-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G034300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class XI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2UFL2"/>
    <dbReference type="Gramene" id="KJB54440">
        <property type="protein sequence ID" value="KJB54440"/>
        <property type="gene ID" value="B456_009G034300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768244"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd15475">
        <property type="entry name" value="MyosinXI_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01384">
        <property type="entry name" value="MYSc_Myo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000002">
        <property type="entry name" value="Class V myosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000011">
        <property type="entry name" value="Myosin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1590:FF:000006">
        <property type="entry name" value="Myosin XI D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000001">
        <property type="entry name" value="unconventional myosin-Va"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037975">
        <property type="entry name" value="MyosinXI_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036018">
        <property type="entry name" value="MYSc_Myo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF772">
        <property type="entry name" value="MYOSIN-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="7 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="8"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="62"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="12">
        <location>
            <begin position="1162"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="877"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="156"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB54440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1530" mass="172805" checksum="3D0C9C55124BCD20" modified="2015-04-29" version="1">MAAPVNIIVGSHVWVEDPALAWVDGEVFKISGEEVHVHTTNGKTAVANISKVFPKDTEAPPGGVDDMTKLSYLHEPGVLHNLAMRYELNEIYTYTGNILIAINPFQRLPHLYDTHMMEQYKGAGFGELSPHVFAVADVAYKAMMNEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRSGVEGRTVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKNGRISGAAVRTYLLERSRVCQISNPERNYHCFYLLCAAPPEVREKFKLGDPKSFHYLNQSSCYALDGVDDAQEYLATIRAMDIVGISEEEQEAIFCVVAAILHLGNIEFAKGADVDSSVIKDEKSRFHLNMTAELLKCDIKSLENALIKRVMVTPEEIITRTLDPVAAVGSRDALAKTIYSRLFDWLVDKINFSIGQDPNSKQLIGVLDIYGFESFKLNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEEINWSYIEFVDNQDVLDLIEKKPGGIIALLDEACMFPKSTHETFAQKLFQTFKNNKRFIKPKLSRTSFTISHYAGEVTYLADLFLDKNKDYVVAEHQDLLTASKCSFVASLFPPPAEESSKSSKFSSIGSRFKLQLQSLMETLNSTEPHYIRCVKPNNVLKPAIFENASIIQQLRCGGVLEAIRISCAGYPTRRTFYEFLHRFGVLAPEILAGNHDDKVACQMILDKMGLKGYQIGKTKIFLRAGQMAELDARRAEVLGNAARTIQRQIRTYIARKEFIELRKAAIMLQSHWRGILACKLYEQLRREAAALKIQKNFRRHIARESYLTVRQSAITLQTGLRAMTARNEFRFRKQTKAAIIIQAAFRCHVAYSYYKSLQKAALTTQCGWRRRVARRELRKLKMAARETGALKEAKDKLEKRVEELTWRLQLEKRLRTDLEEEKAQEIAKLHDALHAVQIQVEEANARVIKEQEAARKAIEEAPPVIKETPVIVEDTEKVNSLAAEVENLKASLLSETKAAEEARNACTDAETRNAELVKKLEESERKVDQLQESVQRLEEKLANSESEIQVLRQQSLAISPTGKSLTARQRTMILPRTPENGNVLNGETKVPSDTTLALSNVREPESEEKPQKYLNEKQQENQDLLIKCISQNLGFSGSKPIAACVVYKCLLHWRSFEVERTTVFDRIIQTIASAIEVQDNNDVLAYWLSNSSTLLLLLQHTLKASGAASLTPQRRRATSASLFGRMSQGLRASPQSAGLSFLSGRGLSRLDDLRQVEAKYPALLFKQQLTAFLEKIYGMIRDNLKKEISPLLGLCIQVPRTSRASLVKGRSQSNAVAQQALIAHWQSIVKSLDRYLKIMKSNHVPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEQWCSEATEEYAGSAWDELKHIRQAVGFLVIHQKPKKSLNEITKELCPVLSIQQLYRISTMYWDDKYGTHSVSSDVIAKMRVMMTEDSNNAVSSSFLLDDDSSIPFTVDDISKSLQQVDITDIDPPSLIRENSGFGFLLPRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGH4</accession>
    <name>A0A0D2UGH4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gnk2-homologous domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_010G175900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGH4"/>
    <dbReference type="STRING" id="29730.A0A0D2UGH4"/>
    <dbReference type="Gramene" id="KJB67126">
        <property type="protein sequence ID" value="KJB67126"/>
        <property type="gene ID" value="B456_010G175900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYHICST"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000003">
        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32099:SF42">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32099">
        <property type="entry name" value="CYSTEINE-RICH REPEAT SECRETORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265582" description="Gnk2-homologous domain-containing protein" evidence="4">
        <location>
            <begin position="24"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="5">
        <location>
            <begin position="29"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="5">
        <location>
            <begin position="138"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB67126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="367" mass="40774" checksum="705991ECF0E0ADF7" modified="2015-04-29" version="1">MMMVDSFTKVFLVAVCLSTFSFGSLEDLTRWYYFCSNATTLTGNIVYAANVDQLFSYLSTKATEHDGFFNTTAGQEPNMVYGLFLCRGDARPEICRDCINLAAADVVKLCPNQSWAIIWYNQCMLRYSNRSIFSSMAERPNVSLSYRVDAMEPYRFNRLVATVMKDIATRAPNATSRTKKFSTKEATFNAFQTLYSLAQCTPDISSEDCYRCLQDAIADLQFHLGGKQSGFAMYPSCTAQYQTSPFYSLNQTGLAKPPVSPQHPLLLPPPPPPGKRGISSQTVIKIVVSTVGFLVLSCFLCCVLGWKATKKLTARKTRNDELKAMALQSLRFDLSIIEAATKNFAEVNKIGAGGFGSVYKNLKNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMZ0</accession>
    <name>A0A0D2UMZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G024900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMZ0"/>
    <dbReference type="SMR" id="A0A0D2UMZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2UMZ0"/>
    <dbReference type="Gramene" id="KJB69409">
        <property type="protein sequence ID" value="KJB69409"/>
        <property type="gene ID" value="B456_011G024900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69411">
        <property type="protein sequence ID" value="KJB69411"/>
        <property type="gene ID" value="B456_011G024900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777055"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LLWAQEI"/>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="1">
        <location>
            <begin position="78"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB69411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="243" mass="27884" checksum="94C979D7C47B1F16" modified="2015-04-29" version="1">MSLFWIVIRRLAEIEERMATSKKVITREEWEKRLNDVKIRKEDMNKLVMNFLVTEGYVEAAEKFRMESGTEPDIDLATISDRMAVKKAVQCGNVEDAIEKVNDLNPEILDTNPQLFFHLQQQRLIELIRNGKIEEALEFAQEELAPRGEENQTFLEELERTVSLLAFEDVSNCPLGELLDISQRLKTASEVNAAILTSQSHEKDPKLPSLLKMLIWAQNQLDEKAAYPRINNLSNATLEDPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ99</accession>
    <name>A0A0D2UQ99_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G071000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQ99"/>
    <dbReference type="STRING" id="29730.A0A0D2UQ99"/>
    <dbReference type="Gramene" id="KJB70386">
        <property type="protein sequence ID" value="KJB70386"/>
        <property type="gene ID" value="B456_011G071000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKSHCSA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF25">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL37X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="114" mass="12762" checksum="18F662ECB7C411AC" modified="2015-04-29" version="1">MGRLVGGIGMHSPLCSGPTTKRGKGIWSFGKRRNKTHTLCKSHCSACAFPADHKRTCKCLVRFFFVIKIVKAIRRKTTGTGRMRYLRHVPRRFKTGFREGTKAAPRKKVATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URH3</accession>
    <name>A0A0D2URH3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-[acyl-carrier-protein] dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G112700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URH3"/>
    <dbReference type="STRING" id="29730.A0A0D2URH3"/>
    <dbReference type="Gramene" id="KJB71249">
        <property type="protein sequence ID" value="KJB71249"/>
        <property type="gene ID" value="B456_011G112700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775970"/>
    <dbReference type="eggNOG" id="ENOG502QQPZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="4155at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01288">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000001">
        <property type="entry name" value="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000582">
        <property type="entry name" value="PRK00006.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272:SF1">
        <property type="entry name" value="3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025049"/>
        </source>
    </evidence>
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        <source>
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                <person name="Byers R."/>
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                <person name="Yoo M.J."/>
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                <person name="Duke M.V."/>
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                <person name="Wang Z."/>
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    <dbReference type="Gramene" id="KJB75666">
        <property type="protein sequence ID" value="KJB75666"/>
        <property type="gene ID" value="B456_012G050900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780945"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTHGNTR"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000381">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF452">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="199"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="303"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="505"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="606"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="641"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB75666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0600970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="89241" checksum="5704F3D49B65A505" modified="2015-04-29" version="1">MILFLLKIPSILQKTNAIPSFNSRCLFLYHSTSHKVENFASLLENCKDFVSLRKLHACIFTNGICQSTFISSKLLTCYQKFGSSLESRWVFDGIIKSNIFLRNSVLVGCFRSGQYGEVLRLYLKLKQKKIGFDCSAITFTLKSCAELGSFGFGKGVHLDVLKFGLSKDGFVGSSLICLYSKNGDMVGASKVFDEITERDVVVYTSMITGYALVGGHITYKAFEFARLMQKEGIDPNRVTMVSLLQAAAELEALEEGRSIHGYAIRRGIGCSDEVFETSLMDMYIKCKVPTMAACIFGRMKMKTIGSWNAMITGYLNMGQPLEALGHFCKMVHENVFPDLISLANGILCCADLKYLQEGKAIQGRIIRIGYELDLIATTALVDMYSKCNDLTRARKLFDVVEKRDVILYNVMMAGYLQNGFATETVDLFIEMVGSGLKPNLGSILNVLSALSEMKNVRGGRSVHGYILKHEFRMNTEVANQIVYMYARCSYIYDARQVFNGIRYKDLISWTSMMMGYIYHANPEEAILLFRMMKREKLDHDSVTLISLLQAFLKLGHLSLAKEVHCHSYRTRLDHETLVINSLITTYAKLGNLNMARNLFEHTNRGCVTSWNTMIAAYGMHGNCKEVLRLFDRMRSEMIKPDDMTFTSILTACSHSGMVEEGLRVFNCMREDYCIIPCEAHYGCIIDLLSRAGRLEEAYELLKLLPARQSASAMAAMLAACRIHGNTELGEVIGHWLLDLEPERPSVYNLVSNLYAESGKWDEAARTRNMAKMRGLKKAAGYSQIELNPRASTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V8D7</accession>
    <name>A0A0D2V8D7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G102900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V8D7"/>
    <dbReference type="STRING" id="29730.A0A0D2V8D7"/>
    <dbReference type="Gramene" id="KJB65600">
        <property type="protein sequence ID" value="KJB65600"/>
        <property type="gene ID" value="B456_010G102900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771518"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRFKAKY"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="41"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB65600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="37508" checksum="6930D595276A4950" modified="2015-04-29" version="1">MGICISIASSEIHDQAEDQHHFHENVLYLTETIPSIGTHTHGSLYSKQGTKGLNQDAAILYQEYGIKGGAFCGVFDGHGKNGHIVSNMVRNRLPSLLVSQKYGVAKLEPTPESDNGRRPRKDLVKWKQACVSAFKVMDKEIKLQHNLDCSTSGTTAVVVVRQGEVLVIANLGDSRAVLGTMTEKGIKAVQLTTDLKPGLPSEAERIRNCKGRVLALKEEPHIPRVWLPHEDSPGLAMSRAFGDFLLKDHGLIAVPDVFYHRLSPNDHFIVLATDGVWDVLNNDQVASIVMEAESEQATARTVAEAATASWKRKFPSSKVDDCTVVCLFLQDKQHPSSLAPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VC93</accession>
    <name>A0A0D2VC93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G112200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VC93"/>
    <dbReference type="STRING" id="29730.A0A0D2VC93"/>
    <dbReference type="Gramene" id="KJB80726">
        <property type="protein sequence ID" value="KJB80726"/>
        <property type="gene ID" value="B456_013G112200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784145"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEWTLFL"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.60:FF:000003">
        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LSM_dom_sf"/>
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        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF26">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="484"/>
            <end position="510"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="516"/>
            <end position="539"/>
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    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="12">
        <location>
            <begin position="535"/>
            <end position="593"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="124"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="55"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="102"/>
            <end position="116"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB80726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="716" mass="81996" checksum="6AA05C9EEFE0D779" modified="2015-04-29" version="1">MEAQNQNKQKPNSDQVVLFMDEPNSKHKESSPQAQAQADSNNITLPLSQQQTPAKTKTLRRLNFSKPRARFAETTFPLTPKPIPESDENQPLYPHHETSSTDSDDDWFDDDEEDGNVGDSKEAEYRRRRRKRKINRRALIEFVLFIIIMICLICSLTLQSLQHKLCWGLELWKWCLMIMVLFCGRLVSAWVVGFMVFLIERNFMLREKVLYFVYGLRKSFQNCAWLGLVLICWMIMFPDIHKQNIVVKKTFLGLIAVLTGATIWLLKIVLVKVLASSFHVATFFDRMKESVFHHYILDALSGPPLDEEPKKRGLKHAKTMPARLRPEGSGGGVARTLSKKGSRRIDMEKLKKLSLEGRANAWSVKRLVNYVKSSGLSTISRTVDDFGAGKSEINSEWEARTCAQRIFKNVAKPGAKYIEEEDLLKFLNSEEVHTIFPLFEGALETGKISKSSFRNWVVHAYVERKALAHSLNDTKTAVQQLHRLASAIVVVIIIVVSLLVMGVATIKVVFVVTSQLLIVGFMFQNTCKTIFESIIFVFVMHPFDVGDRCVIDGVQMIVEEMNILTTVFLRYDMEKIYYPNSVLLTKPISNFRRSPDMGDTVDFTIDVSTPVEDINALKKAIQLYIDSKPKHWSPKHTLIFKEIENMDKMKLVLCVQHTINHQNYGEKSSRRSELVFELKKIFEALGIKYHLLPQEVHLITNQLNNVMPNANARIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCE0</accession>
    <name>A0A0D2VCE0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G084200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB80169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_013G084200"/>
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    <dbReference type="eggNOG" id="ENOG502QT6C">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="PH_PLC_plant-like"/>
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        <property type="entry name" value="PH, RCC1 and FYVE domains-containing protein 1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Vasodilator-stimulated phosphoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Brevis_radix_dom"/>
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    <dbReference type="InterPro" id="IPR027988">
        <property type="entry name" value="BRX_N"/>
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        <property type="entry name" value="PH-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
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    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="Ub_ligase/GEF_domain"/>
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    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF358">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION (RCC1) FAMILY WITH FYVE ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08381">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13713">
        <property type="entry name" value="BRX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51514">
        <property type="entry name" value="BRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="244"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="306"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="358"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="412"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="479"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="530"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="582"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="9">
        <location>
            <begin position="638"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="BRX" evidence="10">
        <location>
            <begin position="965"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="794"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="835"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="816"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB80169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1025" mass="111001" checksum="7659B70E562D72C4" modified="2015-04-29" version="1">MADSHRNGLFERDVNQAITALKKGTCLLKYGRRGKPKFCPFHLSNDESKLIWYSGKEEKQLKLSQVSRIIPGQRTAVFHRYPQPEKEYQSFSLICNDRSLDLICKDKDEAEVWFVGLKALISHGTCRKWKIEVGSDAASVDTPKSHNRRTSPNSHFDRGDAQGIQVPYEAHTRLGKAFADIITHAASAKISNQVDSVEFGLLSTGSVENLNGRSSGADAIRVSLSSAVSSSSHGSCHEDNDALVDIFIWGQGIGGGILGGSGDKIGSSFNTKMDALLPKALESKMVVDAHNIACGSRHAAIVTKQGEIFSWGEESGGRLGHGVEADVPRPKLIDTLRGMNFESVACGEYHTCAITVSGDLYTWGDGTHNSGLLGHGSEVGHWIPKRVSYLDGMHVSYVSCGPWHTALVTSGGQLFTFGDGSFGALGHGDCSSTTVPREVETLSGLRTTRVACGAWHTAAIVEVGTESSGNGSPVSSSSTKLFTWGDGDKGQLGHGDKEPRLCPQSVAALFDDISQVVCGHDLTVALTTTGRVYTMGSSAYGQLGSPTTDGKVPTQVEGKITDSIVEEIACGSYHVAILNSKKEVYTWGKGTNGQLGHGDTDDRNTPTLVNFLKDKQVKSVVCGSNFSAVVCLYKWVSSADHSMCSGCRNPFGFRRKRHNCYNCGLFFCKACTMRKSLKASLAPTINKPYRVCDDCFAKLKKGADPVSNAWTPKVRNGIFPRKSNESIDKDVLAPRSHTQLSRLSAAGSCNQSESGNCKHELKLDLQNRTLFPAQNGNFHLGGFYTPKLSLSPVGDSKKNLPVSVSRKTSRAASPASGKSSTRSSTVTFDDSKQMNDGLNQEIITLRAQVEDLTCKSQHLEAELENTSRRLKEVTAIAENEAEKCKAAEEAIKSLTAQLEEAANRLPTYHNAGNTSPMAKHNSDIEHVFSSSSHASSMMSSAPSNDKCNANNLSTSHGTKVQTKKSETVIHDEPGVYITLSPFPDGSNALKRVRFSRKHFTEEQAEKWWAENGAKVCERHNIIRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VEC4</accession>
    <name>A0A0D2VEC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DOG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G157600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VEC4"/>
    <dbReference type="STRING" id="29730.A0A0D2VEC4"/>
    <dbReference type="Gramene" id="KJB81711">
        <property type="protein sequence ID" value="KJB81711"/>
        <property type="gene ID" value="B456_013G157600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0657">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000019">
        <property type="entry name" value="BZIP family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025422">
        <property type="entry name" value="TGA_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR PERIANTHIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45693">
        <property type="entry name" value="TRANSCRIPTION FACTOR TGA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14144">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51806">
        <property type="entry name" value="DOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DOG1" evidence="10">
        <location>
            <begin position="209"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB81711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="363" mass="41222" checksum="28C827E9A7E3656A" modified="2015-04-29" version="1">MEVVCRCGILLMRQEFLLKTSRLECPKFDGNDFREWWTKLEQYFEVEGIPEVNKQGSIFCLKSNNVGVVANTLHYGALNMSIGATAIVSSGTGCLDTGQFMYQKGVTFGAPLGNGQMENWPDSDNSQQTDTSTDVDTDYKKIASWSSTWSCNAARKSRLRKKAYVQQLESSRLRFTELEQELQRARQQGIFIASGLSGDHGHTVAGNVALAFDMEYGRWLDEHQRLINNLRSAVFRLKNTGAKADVFHMLSGMWKTPIDMCFMWLGGFCSKAYVFHMLYGMWKTPAERCFLWLGGFHSSELMKIVKNHLEPLADQQQGFGRIGYLVVRVALQSNDIELIAVNDPFITTDYMTYMFKYDSVHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL92</accession>
    <name>A0A0D2VL92_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_N002700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL92"/>
    <dbReference type="Gramene" id="KJB84054">
        <property type="protein sequence ID" value="KJB84054"/>
        <property type="gene ID" value="B456_N002700"/>
    </dbReference>
    <dbReference type="OMA" id="HIAEIQF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33033:SF69">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H FOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33033">
        <property type="entry name" value="POLYNUCLEOTIDYL TRANSFERASE, RIBONUCLEASE H-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB84054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16258" checksum="A78324880822D2DE" modified="2015-04-29" version="1" fragment="single">MDWEPPPCGWLKFNVAGVSLDERAGCEGVLRDEKGVVSALFSGNCAVGGLEMVVLMAIIVVEMFTSLFHKVQLPLIIEFDLNTVLNWLKYRSLCPWSLRKLFVKIEDGCRHIAEIQFAVTNHKKNGKAETLAKANMSRKNFFKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W503</accession>
    <name>A0A0D2W503_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G112800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W503"/>
    <dbReference type="STRING" id="29730.A0A0D2W503"/>
    <dbReference type="Gramene" id="KJB80735">
        <property type="protein sequence ID" value="KJB80735"/>
        <property type="gene ID" value="B456_013G112800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782018"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYKTFSC"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000050">
        <property type="entry name" value="Aspartic proteinase CDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000016">
        <property type="entry name" value="Probable aspartic protease At2g35615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051708">
        <property type="entry name" value="Plant_Aspart_Prot_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967:SF66">
        <property type="entry name" value="ASPARTIC PROTEINASE CDR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47967">
        <property type="entry name" value="OS07G0603500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269701" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="26"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="90"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="432" mass="46012" checksum="4B7FEE68AD448328" modified="2015-04-29" version="1">MAAIVSLFAFVFAIVGLSNLSLIQAQKGGFSVELIHRDSPKSPLYNHLDTTYNRVTNALRRSFNRVHRFKPTSVSTMEAEADVIADSGEYLMNISIGTPAFDIVAIADTGSDLIWTQCKPCSQCFPQNAPLFDPTASSTYKTFSCRTSQCGDVEGTSCSSNGSCQYSVSYGDGSYSNGEVAADTLTLDSTTGSPVVIPNVIMGCGHDNDGSFDENTSGIIGLGGGDSSLISQLGSTIDGKFSYCLLPFSEAGNSSKMNFGSDAIVSGNGVVSTPLTKQSPQTFYFLTLEAISVGTNRINFTDKPFGTDQGNIIIDSGTTLTLLPDDFYSELESAVSSMINATKVNGPEGLNLCYDATIEFAVPDITVHFSGADVKLQPLNTFVLISETVACFTFSPLPNFAIYGNLAQMNFLVGYDTIKQTVSFKSTDCSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W8C7</accession>
    <name>A0A0D2W8C7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thylakoid lumenal 17.4 kDa protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G2191002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W8C7"/>
    <dbReference type="STRING" id="29730.A0A0D2W8C7"/>
    <dbReference type="Gramene" id="KJB82890">
        <property type="protein sequence ID" value="KJB82890"/>
        <property type="gene ID" value="B456_013G2191002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTR1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITTADMF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.80">
        <property type="entry name" value="E3 ubiquitin-protein ligase SopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47485:SF1">
        <property type="entry name" value="THYLAKOID LUMENAL 17.4 KDA PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141571">
        <property type="entry name" value="Pentapeptide repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20165" checksum="58C6C25D7988F03E" modified="2015-04-29" version="1" fragment="single">LCVFSLITTADMFSSIEAASKRVPKSEESSSPFKELRTVACGLLAVCTVATASPVIAANQRLPPLSTEPNRCERAFVGNTIGQANGVYDKPLDLRFCDYTNEKSNLKGKSVAAALMSDAKFDGADMSKAVMSKAYAVGASFKVLSGSTFDNAQLEDAVFEDPIIGYIDLQKLCTNTSINAEGRVELGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M792</accession>
    <name>A0A0D2M792_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G059100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_002G059100"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="370"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="390"/>
            <end position="409"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="9">
        <location>
            <begin position="539"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="667" mass="73126" checksum="A91B3EE7938E3354" modified="2015-04-29" version="1">MGVTSDRVEYVCRYGGNGTTTSGVNVSIAAEVTMEIHSVCLPPKESTFQKLKHRLSEIFFPDDPLYRFKDQTWCKKLVLGLQFLFPILQWGSHYDLNLFKSDVVSGLTIASLAIPQGISYAQLANLPPIIGLYSSFVPPLMYSLLGSSRHLAVGPVSIASLVMGTMLSEKVSPVQHPTLYLKLAFTATFFAGLFQASLGFLRLGLVIDFLSKATLVGFMAGAAIIVSLQQLKGLLGIVHFTTKMQLIPVLTSVFHHTKEWSWETIVMGFSFLLLLLTTRHISMKKPKLFWISAAAPLTSVILSTLLVFLIKSKVHGISIFCVCFPLSQIGHLQKGLNPTSTNMLYFNGQYLALAIKTGIVTGILSLTEGIAVGRTFASLKNYQVDGNKEMMAIGLMNMASSCTSCYVTTGSFSRSAVNYNAGAQTAVSNIVLAGTVLVTLLFLMPLFYYTPNVILAAIIITAVIGLIDYKAAYKLWNVDKLDFLACICSFFGVLFISVPLGLGIAVGVSVFKILLHVTRPNTLVLGNIPATQIYQSLNRYKEASRVPSFLILAIESPIYFANSTYLQERLLRWVQEEEERIKANHESTLKCIIIDMTSVTAIDTSGIDMVCELKKMLEKRSLVLVLVNPVGSVMEKMHRSNILGTNSLFLTVGEAVADISASWKPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M7E8</accession>
    <name>A0A0D2M7E8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G063200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB13222"/>
        <property type="gene ID" value="B456_002G063200"/>
    </dbReference>
    <dbReference type="OMA" id="YKESKMS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021:SF7">
        <property type="entry name" value="PROTEIN FB17, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="122"/>
        </location>
    </feature>
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        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB13222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45442" checksum="F3439066A994C2D9" modified="2015-04-29" version="1">MDDTTSEATSPSSRMDSSSMYNQSNQTYQFRSQQQMSYSQATQDRFLQGEALQQPRRGCCRGKMSEDERKARKRQTDRDYRQNKKAKFVEMTSQNQRLQDQNRELMNENRQLKEEISGLKGKGQLPVEVMRRQDSYISHPPSQVDQNVQLQDHYGMEFTNGDDVYNFDGFWLDELQLPPDDGMTTNGRIALNEPAIEHPESSQSGLCPAKVDKNKLHMFLTKLHPEVGSNVDPSGWTGLLKEEQRRMGRFSFPLSLIPTVERIKVAYGDVSETCLISPSVSEKSYVFFCAMIRDMEHLRLDQVTEDIMLNWGDVIKDALGLGFKVQFAVEHLKKVAYAFFGQSGCKWLNDVDSKISTLEAEVNCWKKKRAEIYEESKMSINAVESFNGVPISTGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M846</accession>
    <name>A0A0D2M846_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G0784001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M846"/>
    <dbReference type="Gramene" id="KJB13497">
        <property type="protein sequence ID" value="KJB13497"/>
        <property type="gene ID" value="B456_002G0784001"/>
    </dbReference>
    <dbReference type="OMA" id="LIICCEE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000195">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF825">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="24"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB13497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="340" mass="38513" checksum="8B673999CC557C32" modified="2015-04-29" version="1" fragment="single">EHGKEDLELPVFDLTTIATATNNFSSNNILGQGGFGPVYKGTLIEGQEIAVKRLSKNSGQGLEEFKNEVTLISKLQHRNLVKLFGCCIRKDEKMLVYEYMPNKSLNYFIFDQTRSKLLDWRIRMHIIDGIARGVLYLHHDSRLKIIHRDLKASNILLDHNMNPKISDFGLARKFGVDQTQAKTKRVVGTYGYMSPEYALDGLFSMKSDVFSFGVLVLEILSGKKNRGFSHPEHDHNLLGHAWKLWMEKRPLELIDPAIGDSYDATEGLRCINVALLCVQQCPPDRPNMSLVLVMLCGDSVLPQPKQPGFFIERNLPMADSISVKNEISSMYRSITSLEPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MQ43</accession>
    <name>A0A0D2MQ43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G171700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2MQ43"/>
    <dbReference type="Gramene" id="KJB20907">
        <property type="protein sequence ID" value="KJB20907"/>
        <property type="gene ID" value="B456_003G171700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789250"/>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AKEYHHQ"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="9">
        <location>
            <begin position="527"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="8">
        <location>
            <begin position="708"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="989"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1145"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="998"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1159"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1274"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB20907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1391" mass="151265" checksum="6CF203701E2B74BB" modified="2015-04-29" version="1">MASNPPFQVEDHTDEDFFDKLVDDDDDDSMGPTVPKFTEGIDSDDTKGFSNLSMGEDSGDEEVDSHAVKEKDPVDTGPAQANVPVVNEPNDSLGFDNSVVETSDHLLEGELSEAGFNQDLGENVGSKNSGVKEVGWNSLFADSNENGVHGFGHYSDFFSDLGENPIGVFPSEAGEIAKTSFVDHNSASTYQQYHDGSHDQVYEASAANNGNEQDLYSIDYWEKMYPGWKYDANSGQWYHVDGSGGDGSWNTDVKAEASYLQQTVQSFAGTMTTLEHGAMENVADWNQVSQVNNGYPEHMIFDPQYPGYYYDLIAQQWFALDSYNASVQSTVQDDGQQNQNGFASTVQNSQTDSSSMYGEHGQGDNYGSLGLGSPGGHHNWSDSYGTYKSQGFNMWQPGTAANSGALSSFDANKQSDTSFGLNMPVNNNASNFQSSYNSLQEAQSVNSANQVHTEANGVTGLQSFLPSENFNNQFIQTNLNQNEQVNFSNDFYGSQKSVNVAPQPLQSSQPFPYASNTGRSSAGRPPHALVSFGFGGKLIIMKDGSPLQNSSFGTQDSVGAYISVLNMLEVVNSNTSVSAAAPAACDYFNTLCQQSFPGPLVGGNVSNKDLSKWIDDRIASCESPNMDYGKGENMRMLLSLLKIACQHYGKLRSPFGSDTLLKETDTPESAVAKLFASAKRKDASYGALSHCLQLLPSEGQVRATAIEVQNLLVSGRKKEALQRAQEGQLWGPALVLASQVGEQFYIDTIKQMALHQLVAGSPLRTLCLLIAGQPADVFSTGSTIDGMDLSQQHAEVRTNLMLDDWEENLAVITANRTKDDELVIIHLGDCLWKERSEITAAHVCYLVAEANFESYSGSARLCLIGADHWKFPRTYASPEAIQRTELYEYSKVLGNSQFVLLPFQPYKLIYAHMLAEVGKVSDSLKYCQAVLKSLKTSRVPEVETWKHLVLSLEERIRIHQQGGYATNLAPVKLVGKLLNFFDSTAHRVVGGLPPPPTSASNGNSQGNDHFNQQTGPRVSASQSTMAMSSLMPSSSMEPINDWEGRGADGKMTMHNRSVSEPDIGRTTRQVDSSKETGPSNEQGKQSVSPGASRFSRFSFGSQLFQKTFGLVLRPRPDKQAKLGEKNKFYYDEKLKRWVEEGAEPLAKEPALPPPPTTASFQNGTSDYNLNSALKSESSPPNGSPKFRNPTPIEHASGIPPIPTSSNQFSARGRMGVRARYVDTFNKGGGGQANLFQSPAVSSVKPAAAANAKFFIPMPISTTMSEQSMEAITENAQEENATNNNPSTPTSTSSVNDFCQSPRPLPAVTRPRFPSMDNIPQEVFTTNANAYPSPHSRRTVSWSGGNFDDPLSPPSKPEIRPSGEAPGKPPPLFMPGPANGSFGDEQLHEVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MS46</accession>
    <name>A0A0D2MS46_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_004G016300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MS46"/>
    <dbReference type="STRING" id="29730.A0A0D2MS46"/>
    <dbReference type="Gramene" id="KJB21827">
        <property type="protein sequence ID" value="KJB21827"/>
        <property type="gene ID" value="B456_004G016300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNPQDKM"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010277">
        <property type="term" value="F:chlorophyllide a oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03480">
        <property type="entry name" value="Rieske_RO_Alpha_PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050584">
        <property type="entry name" value="Cholesterol_7-desaturase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013626">
        <property type="entry name" value="PaO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266:SF32">
        <property type="entry name" value="CHOLESTEROL 7-DESATURASE NVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21266">
        <property type="entry name" value="IRON-SULFUR DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08417">
        <property type="entry name" value="PaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="15">
        <location>
            <begin position="89"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB21827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="523" mass="59952" checksum="E73602978441B8B5" modified="2015-04-29" version="1">MDVLRAASAIGPLPCILTTATRNKTQFPKSIFHNLNLKLPALTRNGSKSRLVMTLSSTPSSTMESIEPPMPELEADGREKERLDWYSQWYPVMPVCDLDKRVPHGKKVLGLDLVVWWDKNENEWKVFDDTCPHRLAPLSEGRIDQWGRLQCVYHGWCFNGNGDCKIIPQAPLDGPPVHTFKKACVAVYPSVVQHDIVWVWPNADPQYKDIITKKKPPYIPVLDDPSFSKWMGNRDLPFGYEFLTENLMDFAHLPYAHYGIIRTPTPKVKVDREGGRPLDMKVKKLDINGFVEQEWGNSNFIAPCIIHTFADAEVDEENHRLMLIFMCVPVSPGNSRLIWIFPRKFGVWIDQIVPRWMFHIGVNLVLDSDLYLLHVEERKIMEIGATNWQKACFLPTKSDATVVGFRRWFNKYAGGEIDWKGKYSGALPPSPPREQLMDRYWSHVVNCKSCNSAYEGLKALEVMLQIMSVVLIGIIAVTKQKIMSMVAKTTMVSMAIICFAASKWLAHFIYKNFHYHGYNHAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N2K0</accession>
    <name>A0A0D2N2K0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-L-fucosidase</fullName>
            <ecNumber evidence="3">3.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alpha-L-fucoside fucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G231200</name>
        <name evidence="13" type="ORF">Gorai_015392</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="3"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N2K0"/>
    <dbReference type="STRING" id="29730.A0A0D2N2K0"/>
    <dbReference type="Gramene" id="KJB26222">
        <property type="protein sequence ID" value="KJB26222"/>
        <property type="gene ID" value="B456_004G231200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792415"/>
    <dbReference type="eggNOG" id="KOG3340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFFDSWF"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000093">
        <property type="entry name" value="Alpha-L-fucosidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000052">
        <property type="entry name" value="Putative alpha-L-fucosidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF27">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="11">
        <location>
            <begin position="81"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB26222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0584588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="520" mass="58297" checksum="9ACB7D190521403B" modified="2015-04-29" version="1">MPNPSFNSRKPISVHALPIFVSLFFSAIPHSALKIPPPLPILPLPSASQLQWQLSSMALFLHFGPNTFTDSEWGTGHASPSVFNPTLLNASQWVHVAKEAGFSRVILTAKHHDGFCLWLSEYTDYSVKASPWRNGKGDVVAELAAGAKEAGIALGLYLSPWDRHESCYGKTLEYNEFYIGQMTELLTRYGDIKEVWLDGAKGEGEKDMEYYFDAWFSLIHQLQPDAVIFSDAGPDTRWIGDEAGVAGSTCWSLFNRSNAVIGGTNPQYSQGGDPHGHDWVPAECDVSIRPGWFWHASQVPKSALELLDIYYKSTGRNCLLLLNVPPNSSGLISDEDIQALQEFKELRRSIFSNNLAEKGLLTASSIRGGNDNYQFSPYNVFEESIYTYWAPEEDQRDWVLYLDLQESVSFNVLQVQEPIHMGQRIIKFHLEILSGGRWKNVISGTTVGYKRLLQFPTVQSRYLKLVIDMSRADPLISYMGLHMDRFSILSHASNTTSQIYVNGSQVLRQVPNKDSQTATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N5S5</accession>
    <name>A0A0D2N5S5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G250000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bTHX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N5S5"/>
    <dbReference type="STRING" id="29730.A0A0D2N5S5"/>
    <dbReference type="Gramene" id="KJB27492">
        <property type="protein sequence ID" value="KJB27492"/>
        <property type="gene ID" value="B456_005G250000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795375"/>
    <dbReference type="eggNOG" id="ENOG502S834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQWCGAV"/>
    <dbReference type="OrthoDB" id="911986at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032544">
        <property type="term" value="P:plastid translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030826">
        <property type="entry name" value="Ribosomal_bTHX/bTHXc/bTHXm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044695">
        <property type="entry name" value="Ribosomal_bTHXc/bTHXc_plant"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04560">
        <property type="entry name" value="ribo_THX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34550">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S31, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34550:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BTHXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17067">
        <property type="entry name" value="RPS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB27492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10003" checksum="1042EBDA811119D6" modified="2015-04-29" version="1">MAMIQWCGAVARRVVMKQWPPLSSASPIGAMASPPAPTVCGRGDKKTKKGKRFKGSYGNARPKKEKKIERIKDKVEVPRSTPWPLPFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8X9</accession>
    <name>A0A0D2N8X9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial transcription termination factor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G074700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8X9"/>
    <dbReference type="STRING" id="29730.A0A0D2N8X9"/>
    <dbReference type="Gramene" id="KJB28887">
        <property type="protein sequence ID" value="KJB28887"/>
        <property type="gene ID" value="B456_005G074700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QYF3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000013">
        <property type="entry name" value="uncharacterized protein LOC106769908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB28887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31735" checksum="1D3A4E21BB22E59F" modified="2015-04-29" version="1">MDLWFSCLGWGLPLPFLSDLTKPHFFSIQHLQHALLQDRVWGLLNFTFQVQEIDNQSKGFQIIGILSPIIVAFLGMLGNSLASSLLTFDSATSCFCVPDAATSAPNIVPFSVTFSSRLPQTVIRRVGSSHFSPHKWAINVNAEGKTWEACRQALSAFGFSDEEEDKILGKAFGHVHSPYWGEERKKEEPRFEIINEILEYLRSLGLSDDDLRKLLKKFPEVLGCDIEHELRTNVQILEKDWGIKGKSLKNLLLRNPKVLGYNVDCKGDCMAQCTRCWVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8Z9</accession>
    <name>A0A0D2N8Z9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G130300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8Z9"/>
    <dbReference type="STRING" id="29730.A0A0D2N8Z9"/>
    <dbReference type="Gramene" id="KJB09227">
        <property type="protein sequence ID" value="KJB09227"/>
        <property type="gene ID" value="B456_001G130300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB09228">
        <property type="protein sequence ID" value="KJB09228"/>
        <property type="gene ID" value="B456_001G130300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793473"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WCRHSRN"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF3">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395374" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB09228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="145" mass="16443" checksum="9CBE5BCA2E6FF63D" modified="2015-04-29" version="1">MKNDCRFALLLLFLTSVTLHTKAEVITLTPDTFSDKVKEKDTAWFVKFCVPWCKHCKNLGTLWDELGKAVEGEDEIEIGEVDCSVSKPVCTKVDIHSYPTFKLFYDGEEVAKYQGKRDVESLKAFALEEAEKAAEKAQLDTDKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9I7</accession>
    <name>A0A0D2N9I7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_005G085600</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9I7"/>
    <dbReference type="STRING" id="29730.A0A0D2N9I7"/>
    <dbReference type="Gramene" id="KJB29122">
        <property type="protein sequence ID" value="KJB29122"/>
        <property type="gene ID" value="B456_005G085600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VECTRIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000043">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF511">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247907" description="Protein kinase domain-containing protein" evidence="21">
        <location>
            <begin position="25"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="416"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB29122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="82990" checksum="BBECFDD8E2A210CF" modified="2015-04-29" version="1">MGSIRSLVLMQLMILLNVILTVKASTPAVAKPGCRSRCGDVIIPYPFGTGGDCNITAGFFINCNTSFIPHKPFFGDLEVINISTDGQLRILSNTSYDCYDTSYRNWFFYDLLSFEFSINNNKNKFTAIGCDTVAVVQDFYGKCYATGCLSLCNNITDVSNGSCSGIGCCQTSIPKNVRSYNISLDSYANHTNVLAENPCSYAFVAEVDSYTFSASDLGGFEFQSRQFPITFDWNIGNTSCNKANMDVNNFACKEYSKCVDSENNSGYLCKCLEGYGGNPYLSNGCQDINECESMSPCNGTARCTNLPGTYKCSCPVGYEGDGKKSGTGCSLPNKDQSKTSPLIAALGVAIGFLGLLLGIVLWCWMLRQRQISKLREANFQQNGGILLREQLSKRQGYREDVKFFTAEELEKATNNYNESRILGQGGQGTVYKGILADNQIVAIKKSIIGYPSQVEQFINEIMVLYKINHRNVVKLLGCCLETQVPLLVYEYITNRTLFHHLHNDDAISYLSWETRLRIATETAEALSYLHSAASIPIIHRDIKLANILLDDNYTPKVSDFGASRLIPSDEAQITTIVQGTFGYLDPEYMLSSLLTEKSDVYSYGVVLMELLTGQKVVCFKRPEENRVLPLYFTSLMKEDRLLDILDPRVLNDENVEQLMEVAILARRCVRVKGEERPTMKEVAHEFAGLQAMPKHPWSKSNLVSEESEYLLGKFPSTYDDGVTSSSIGMGYDSINNKITFELEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NC51</accession>
    <name>A0A0D2NC51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="15">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_001G204400</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="15"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NC51"/>
    <dbReference type="STRING" id="29730.A0A0D2NC51"/>
    <dbReference type="Gramene" id="KJB10498">
        <property type="protein sequence ID" value="KJB10498"/>
        <property type="gene ID" value="B456_001G204400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801212"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYLYSWI"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF22">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
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    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB10498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="143" mass="16251" checksum="5AEE60B0E71D4D58" modified="2015-04-29" version="1">MEMIMGKEYGYVAIVVVVYCCLNMWMGFQVVKARKKYKVNFPNLYALESENKNAKIFNCVQRGHQNSLEMMPVFFILIVLGGMGHPCVSAALGLFYTVTRYFYFTGYSTGDPQNRLTIGKYGFLALFGLMICTISFGIKLLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NIB6</accession>
    <name>A0A0D2NIB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G259400</name>
        <name evidence="13" type="ORF">Gorai_017544</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NIB6"/>
    <dbReference type="STRING" id="29730.A0A0D2NIB6"/>
    <dbReference type="Gramene" id="KJB32747">
        <property type="protein sequence ID" value="KJB32747"/>
        <property type="gene ID" value="B456_005G259400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795453"/>
    <dbReference type="eggNOG" id="KOG2648">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNALEGM"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990145">
        <property type="term" value="P:maintenance of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
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    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0586821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="464" mass="50757" checksum="21993B8A6FD72AC6" modified="2015-04-29" version="1">MMDPLIEKTGQHKPESALETPLPLQRNAVNSSKPAPKRFVKNQIPDSILNDASLNAAILVLPSNYNFEIHKCVWRVRSTGAKRVALQFPEGLLMYSLVISDILTSFADVTHCFILGDVTYGACCVDDLSAVALGADLLIHYGHSCLVPIDATKIPCLYVFVEIKINVDGLVNTIKHNLGSSKESIVLAGTIQFSSAIRSAKPELEKRGFRVLIPQSKPLSAGEVLGCTAPKIGSIANANESVAVFVADGRFHLEAFMIANPGIKAFRYDPYLGKLFLEEYDHKGMRETRRRAIEKAKSAKSWGIVLGTLGRQGNPKVLERLEGKMKEKGYDYTVILMSEISPVRIALFEDAVDAWVQIACPRLSIDWGDAFLKPLLTTFEAEIALGEIPGWWEKDGCGSCGNGLSCSESKSCCGDGNGMKDFHGDYPMDYYAQNGGEWNSSYVKKSVRLMRRNIAPSSGNGAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NL85</accession>
    <name>A0A0D2NL85_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G111500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NL85"/>
    <dbReference type="STRING" id="29730.A0A0D2NL85"/>
    <dbReference type="Gramene" id="KJB14108">
        <property type="protein sequence ID" value="KJB14108"/>
        <property type="gene ID" value="B456_002G111500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783096"/>
    <dbReference type="eggNOG" id="ENOG502QWA4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1927968at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040420">
        <property type="entry name" value="At1g76660-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31798">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31798:SF3">
        <property type="entry name" value="OS01G0103800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB14108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="51662" checksum="2BC7EBCF96382848" modified="2015-04-29" version="1">MGSEQNRFPQQERQKRWGGCWGAFSCFGGTQKGGKRIVPASRMPEGNASATQPNNGTQAVAGLTNQATTLAPSLLAPPSSPASFTNSALPSTAQSPSCFLSLSANSPGGPSSTMFATGPYAHETQLVSPPVFSTFTTEPSTAPLTPPPELAHLTTPSSPDVPFARFLTSSADLESANKTNYIAANDLQATYSLYPGSPASSLRSPISRTSADCLSSSFPEREFPPQWDPSISPQNGKHSRSGSGRLFGHDVTGSSIGSQDTNFFCPATFAEFYLDQNPLPHAGGRLSVSKDSDVYPTSCSGHQNKQSKSPKQDVEELEAYRASFGFSADEIITTTQYVEITDVTDDSFTMRPFPIDKPAFEESTEPASIAKGSKTDRIQENFLDEKKGKSKSDIVNWAVHHDVQVACNGYEDQKSRRQVGDVSGSSTPINHTLTDEEDIYLKKSSSRSRKYQLGLSSSDAEIDYRRGRSLRGKGDFECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NRQ4</accession>
    <name>A0A0D2NRQ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G229000</name>
        <name evidence="14" type="ORF">Gorai_023487</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NRQ4"/>
    <dbReference type="STRING" id="29730.A0A0D2NRQ4"/>
    <dbReference type="Gramene" id="KJB16403">
        <property type="protein sequence ID" value="KJB16403"/>
        <property type="gene ID" value="B456_002G229000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786227"/>
    <dbReference type="eggNOG" id="ENOG502QTZV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWKFKEF"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000722">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF8">
        <property type="entry name" value="RECEPTOR PROTEIN KINASE-LIKE PROTEIN ZAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715538" description="Protein kinase domain-containing protein" evidence="11">
        <location>
            <begin position="22"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="339"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0581306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="641" mass="70084" checksum="41F9F65BE92E91A9" modified="2015-04-29" version="1">MLRLVLKVVSFLFLFTSLVSSLNSDGLSLLALKAAVESDPTRCLESWSESDATPCHWLGIGCTRKRVTSIFLPNKGLTGYIPSELGLLDSLTRLSLAQNNFSKLIPYHLFNATNLVYIDLSHNSLSGSVPPQIKSLKNLAHLDLSSNSLNGSLPESLVELKSLRGTLNLSFNKFSGEIPASYGEFPVMISLDLRHNNLTGKVPQVGSLVNQGPTAFTGNPNLCGFPLGNLCPEAQNPRAILNPEENPENPQGLTPVFYDGNGDKHKEKIGSVAAPLISGVSAVIGAVSVLVWLVRRKWKTGEDKMGKEKKREEVEEEGQNGKFMVVDEGFALELEDLLRASAYVVGKSRSGIVYKVVAGRGSGTLGSTVVAVRRLSEGDAPLKFKEFEAEVEAIGRVNHPNIVRLRAYYYADDEKLLVTDFIRNGSLYAALHGGPTDNLPPLSWAARLRVIQGTARGLMYIHESSPRKYAHGNLKSTKILLDNELQPYISGFGLTRLVSGTSKYASLITKKLISTQTVAVGSRISTPNSYLAPEARVYGSKFTQKCDVYSFGIVLLEVLTGQLPDAGPENDEEGLEGLVRKAFREERPLSEIIDSTLLTEVYAKKQVVAAFHIALNCTELDPELRPRMRTVSESLDRIKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NRW4</accession>
    <name>A0A0D2NRW4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="3">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G132200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="3"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NRW4"/>
    <dbReference type="STRING" id="29730.A0A0D2NRW4"/>
    <dbReference type="Gramene" id="KJB35887">
        <property type="protein sequence ID" value="KJB35887"/>
        <property type="gene ID" value="B456_006G132200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0633">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="386"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="92"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB35887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="420" mass="46839" checksum="7A3BF52565BD29D7" modified="2015-04-29" version="1">MGVSNIFNPASLCLLKSNVRQTQRPIRSFEGNQKGLIMATFSSSPSTVSVEHVNQKLSGDSFIRPHLRKLSPYQPILPFEVLSAKLGRKPEDIIKLDANENPYGPPPEVLEALGSLKFPYIYPDPESRQLRAALAEDSGIESDYILVGCGCDELIDLIMRCVLDPGDKIVDCPPTFTMYEFDAGVNGAQVIKVPRKPDFSLNIEAIAEAVEHEKPKCIFLTSPNNPDGSIISDEVLLKILDMPILVVLDEAYIEFSGNESRMQWVKKHDNLIVLRTFSKRAGLAGLRVGYGSFPLSIIEYLWRAKQPYNVSVAAEVAACAALQNPKYLELVKDALIQERDRLFKLLKEVPFLNPYPSYSNFILCEVTSGMDAKKLKVTFLNPYPSYILISPAPICHCFALFVILFLAIVFMHDCHPSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NX12</accession>
    <name>A0A0D2NX12_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G225200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NX12"/>
    <dbReference type="STRING" id="29730.A0A0D2NX12"/>
    <dbReference type="Gramene" id="KJB37897">
        <property type="protein sequence ID" value="KJB37897"/>
        <property type="gene ID" value="B456_006G225200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800398"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HFWAVIR"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47493">
        <property type="entry name" value="OS08G0520200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47493:SF3">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="142"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="177"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="212"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB37897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58563" checksum="7C97278BA6F47BA4" modified="2015-04-29" version="1">MENAVTLNLDCKITLRWQSSINSDNKKSILIQTHFPKSTRHCCCLSSLSSSPSTPRRPPDGCSSKTHTTLLVETYHHHRRLRALIEKLEKEGSCPMQILGDDGDWTKNDFWAAVKFLRHAFRSNEILQVFRMWKNIEKSRINELNYEKIIGLFCEERMVEEAVEALQEMEGYGLRPSLEIYNSIIHAYAKNGKFNDASFFLNEMKEIGLEPETDTYDGLIEAYGKYKRYDDIGACLKTMELDGCSPDHFTYNLLIREFSRGGLLQKMEQVYRVMISKKMNLQPSSLVAMLESYANFGILDKMEKVYRKVVNSSSLKEDTVRKLANVYIKNYMFSRLDDLGIDLSSRTGRNDLVWCLRLLSHACLLSRKGIDSVIQEMDEAKALWNVTIVNIILLAYLKMKDFTHLRSLLSQLPSRQVRPDLTTVGILFDAIEIGFDGAKTLETWRKMVLYRAVELNTDPLVLTAFGKGHFLRDCEEAYTSLEPKARDKKTRTYHQLIDLVIKHKAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NZ83</accession>
    <name>A0A0D2NZ83_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 36</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ESCRT-II complex subunit VPS36</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G2712001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the VPS36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NZ83"/>
    <dbReference type="STRING" id="29730.A0A0D2NZ83"/>
    <dbReference type="Gramene" id="KJB38772">
        <property type="protein sequence ID" value="KJB38772"/>
        <property type="gene ID" value="B456_006G2712001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38773">
        <property type="protein sequence ID" value="KJB38773"/>
        <property type="gene ID" value="B456_006G2712001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38774">
        <property type="protein sequence ID" value="KJB38774"/>
        <property type="gene ID" value="B456_006G2712001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2760">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IXARHAG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000601">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021648">
        <property type="entry name" value="GLUE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037855">
        <property type="entry name" value="Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13128:SF12">
        <property type="entry name" value="VACUOLAR PROTEIN-SORTING-ASSOCIATED PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11605">
        <property type="entry name" value="Vps36_ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51495">
        <property type="entry name" value="GLUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GLUE N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB38772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="321" mass="34474" checksum="EB08D80452181BB1" modified="2015-04-29" version="1" fragment="single">MSNFFSKAEVTSSGRPVLLRNEVECHLLSAVDLEPEDHRHFSLLKSGLLILTTHRLIWLPSSSASTPTCASAIPLAAISHIFSSKKSLKSVFHSPRIRFQVLVSSTVRVFDPGSGSGSSSGSGSRSVVVTAVIRGKGDCDGFLVKFWDSWRARAWETTETSGSGSASASGSGAATGTGGGLYSSDGSVRMVGVAGILRKEQEMWESTDKNLQDAFQDLNALMSKAKEMVTLAEKMRLKLLSGTSSQTSGTNDEDMGSKEEMQDWLLSVGIISPVTKESAGALYHQQLSRQLADFVRVPLERAGGMINLIDAYCLFNRARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2N9</accession>
    <name>A0A0D2P2N9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CAF17 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G166400</name>
        <name evidence="6" type="ORF">Gorai_024942</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P2N9"/>
    <dbReference type="STRING" id="29730.A0A0D2P2N9"/>
    <dbReference type="Gramene" id="KJB20813">
        <property type="protein sequence ID" value="KJB20813"/>
        <property type="gene ID" value="B456_003G166400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789200"/>
    <dbReference type="eggNOG" id="KOG2929">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMLVAND"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057460">
        <property type="entry name" value="CAF17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GCV_T_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602:SF0">
        <property type="entry name" value="TRANSFERASE CAF17, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25455">
        <property type="entry name" value="Beta-barrel_CAF17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CAF17 C-terminal" evidence="4">
        <location>
            <begin position="280"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB20813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0582810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="374" mass="41953" checksum="4ED808F69750704F" modified="2015-04-29" version="1">MNRFMPCLLIHHRHLHQLQNAGPLCSHLKSRSVIRFSGPDTIKFLQGLLSNDVRRFGESPNEDNSPVVPPMYAALLTPQGRFLYDFFLYRQSRPEEKLDRNGLVEILADVDGSVLDELLATLKKYRLRSKVDIENVAEDFYCWQRYGRGLSEKTPSVEEPVAASVGWRGGDDRSGSSASNGNDVGWQWFKDPRLDCLGFRGIFPSGTTPPLVESDKETDEEKYLLWRLEKGVAEGSTEIPKGEAIPLEYNFAGLNAISFDKGCYVGQELIARTHHRGVIRKRLLPLKFLDNNGKEVERKVTAGSEVINTASGKKTGSVTTAFGFCGMGVLRLEEAFKGSDSLTILGQEDIKVEAIRASWWPSEWFRDQQHTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PAP0</accession>
    <name>A0A0D2PAP0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G121000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in cooperative interactions with calmodulins or calmodulin-like proteins. Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking. May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PAP0"/>
    <dbReference type="STRING" id="29730.A0A0D2PAP0"/>
    <dbReference type="Gramene" id="KJB23918">
        <property type="protein sequence ID" value="KJB23918"/>
        <property type="gene ID" value="B456_004G121000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791198"/>
    <dbReference type="eggNOG" id="ENOG502QUBM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1686972at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF174">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="6">
        <location>
            <begin position="347"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00045534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB23918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="456" mass="50763" checksum="A2262E7E05BC105D" modified="2015-04-29" version="1">MGLFRRLFGAKKPAQPRPDKDRRRWSFTRSSHPTSSTSHLDALSGPCNGTLDANKRAIAVAAATAAVAEAALAAAHAAAEVVRLTSGGVGSADGSNRRLPQELAAVKIQSAFRGYLARRALRALKALVKLQALVRGHIVRKQTADMLRRMQTLVRLQARARASRSYMTKSFYSTCKISHSRHAVHAHSLKDECQLHVCSTKYDGSSILKRCGSNSNLMDTINLEKARMGSNWLDNWMEESLRNNHRDSPLIHRHADDAKSDKILEVDTWKPNLNCPPCNRNFRTSQHGSAFDYNQSYMAYGSPRKQSGKGSNQIPDNFSAEVLPLSSLKHPGRKDKAILRTADIDNSPQVLSASSSRPGSSARRSPFAKSECSWGYLSGFSGHPNYMANTESFRAKYRSQSAPRQRLEFDKYGSNRRTFQGLWDSERDPAQHVDYRYRYNLASDCLNKLAGAHQGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PPU2</accession>
    <name>A0A0D2PPU2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G083400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PPU2"/>
    <dbReference type="STRING" id="29730.A0A0D2PPU2"/>
    <dbReference type="Gramene" id="KJB29083">
        <property type="protein sequence ID" value="KJB29083"/>
        <property type="gene ID" value="B456_005G083400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNDWSRT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06632">
        <property type="entry name" value="STKc_MEKK1_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000186">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF11">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="190"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="155"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB29083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="508" mass="56225" checksum="0554DBAD30FC7E4C" modified="2015-04-29" version="1">MKKTYTTRNNDKHSMEKPKGLHEAAAVSKKSPRNSYDIEVHPISFHGCSALWDSDSDLGSKSREKKAYPLPQPSASSCRASMESHQRGSSFGSERVSVSSFTSNESSSDDDDDIHGDFSSFRVYEENNSNLWSKGSNSGSKASYMHQSPRYLSPWDATLESPTEKHPCHRLPLPPPTSPNKPPKKSPSKWKKGKLLGRGTFGHVFAGFNSENGTMCAVKEVKVITDDQTSKECLKQLNQEISLLSELSHPNIVQYYGSELGSDKLSVYLEYASGGSVHKLLGEYGPFKEPVIRSYTRQILSGLAYLHARNTVHRDIKGANILVDPNGEIKLADFGMAKHMTSCSSMLSFKGSPYWMAPEVIMNAHGYSLAVDIWSLGCTVLEMATSKPPWSQYEGVAAIFKIANSKGFPEIPNNLSKDAQNFIKLCLQREPTARPTALKLLQHPFVQDQSMVEPTKFNLVDDRRRPSKGSWDEISLASSLPESPCSNSTQQCKSACGSSHRSSYQTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRJ0</accession>
    <name>A0A0D2PRJ0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G121400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRJ0"/>
    <dbReference type="Gramene" id="KJB29853">
        <property type="protein sequence ID" value="KJB29853"/>
        <property type="gene ID" value="B456_005G121400"/>
    </dbReference>
    <dbReference type="OMA" id="AGCNMLV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="68" mass="7616" checksum="E5C4390879CC9404" modified="2015-04-29" version="1">MKGTTTLSNLKRPFCKTCLSIPLRGLNGSLNHLFFNVIAIVWQIIKGRSAGCNMLVVRVIILPPWLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRW1</accession>
    <name>A0A0D2PRW1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methyltransferase PMT26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G094300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRW1"/>
    <dbReference type="STRING" id="29730.A0A0D2PRW1"/>
    <dbReference type="Gramene" id="KJB48927">
        <property type="protein sequence ID" value="KJB48927"/>
        <property type="gene ID" value="B456_008G094300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB48929">
        <property type="protein sequence ID" value="KJB48929"/>
        <property type="gene ID" value="B456_008G094300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB48930">
        <property type="protein sequence ID" value="KJB48930"/>
        <property type="gene ID" value="B456_008G094300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763571"/>
    <dbReference type="eggNOG" id="ENOG502QQH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TADSEHW"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000084">
        <property type="entry name" value="probable methyltransferase PMT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1130">
        <property type="entry name" value="METHYLTRANSFERASE PMT26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB48927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="91137" checksum="E9C33C57B1C42D31" modified="2015-04-29" version="1">MALGKYSRVDNNNNNNNRKSSSSYCSTVTIVVFVGLCLVGIWMLTSSSVVPVQTGNGSAEEKKNQVEDQVTPVSSDNNDSSNTSDFEDNRGDLPDDATKGDANVSLAENDGKGNLNTQENQDNTEETKMAESKKDDEQSASEGGEKSGDNSGGQGDSLENSDDKKSDSDENDKKSEENNEKSDLDDGDKKQDESSSETNGDQADNQIEEMVDQNDNKELEKSPDEPKDDGQLKNQSSNEVFPSGAQSELLNETVTQTGSFSTQATESKVEKETQLSSKKYSWKLCNSTAGPDYIPCLDNLEAIRHLPSTKHYEHRERHCPEEPPTCLVPLPEGYKRPIEWPKSREKIWYYNVPHTKLAQIKGHQNWVKVTGEYLTFPGGGTQFKHGALHYIDFIEESVPDVAWGKRSRVVLDVGCGVASFGGFLFDRSVVAMSFAPKDEHEAQVQFALERGIPAVSAVMGTKRLPYPGRVFDIVHCARCRVPWHIEGGKLLLELNRVLRPGGFFLWSATPIYQDKTEDVEIWEAMVELTKSMCWELVNKTSKDAVNGVAVAAFRKPTSNDCYEQRSKQEPPVCPESDDPNAAWNVPLQTCMHKVPVDASERGSQWPDRWPERLEKAPYWLSSQVGVYGKAAPEDFAADNEHWKRVVTKSYLNGMGISWSSVRNVMDMNAVYGGFAAALKDLSLWVMNVVPIDSPDTLPIIYERGLFGMYHDWCESFSTYPRSYDLLHADHLFSKLNKRCNLVAIVAEVDRILRPEGKLIVRDNVETINELENMLKSMQWEVRMTYSKDKEGLLCVQKSMWRPKEVETIKYAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSI1</accession>
    <name>A0A0D2PSI1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase chain 6</fullName>
            <ecNumber evidence="4">7.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">NADH dehydrogenase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_001G168000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="4"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSI1"/>
    <dbReference type="STRING" id="29730.A0A0D2PSI1"/>
    <dbReference type="Gramene" id="KJB09804">
        <property type="protein sequence ID" value="KJB09804"/>
        <property type="gene ID" value="B456_001G168000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S14H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQINSIG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1200:FF:000003">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase chain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="entry name" value="NADH-ubiquinone/plastoquinone oxidoreductase chain 6, subunit NuoJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005164">
        <property type="entry name" value="PRK06638.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33269:SF17">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0691">RNA editing</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB09804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="211" mass="24095" checksum="9E05C6EC65BF92E5" modified="2015-04-29" version="1" fragment="single">EGRRTMILSVLSSPALVSGLMVARAKNPVHSVLFPILVFRDTSGLLLLLGLDFSAMIFPVVHIGAIAVSFLFVVMMFHIQIAEIHEEVLRYLPVSGIIGLIFWWEMFFILDNETIPLLPTQRNTTSLRYTVYAVKVRSWTNLETLGNLLYTYYSVWFLVPSLILLVAMIGAIVLTMHRTTHGAVKRQDVFRRNAISFRRTIMRRTTDPITR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVM6</accession>
    <name>A0A0D2PVM6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G155700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
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        <property type="protein sequence ID" value="KJB50147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2PVM6"/>
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        <property type="gene ID" value="B456_008G155700"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04666">
        <property type="entry name" value="NUDIX_DIPP2_like_Nudt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000030">
        <property type="entry name" value="Nudix hydrolase 13 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047198">
        <property type="entry name" value="DDP-like_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629">
        <property type="entry name" value="DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12629:SF71">
        <property type="entry name" value="HYDROLASE 13, MITOCHONDRIAL, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB50147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="222" mass="25504" checksum="D2E2B4813F8107D4" modified="2015-04-29" version="1">MSFLPARKGRHRQRYQDHLRLVAGCIPYRLQKDVEDSNSSVTSRINVLMISTPNRDDLVFPKGGWENDETVHEAACREALEEAGVKGILDEDPLGVWEFRSKSRQNCCNMEGGCRGYMFALEVTEELDSWAEQTSYKRQWLSPEEAYKFCRYDWMKDALQVFLRAIEERGSRRAEKLVELPMFPAADSMAEHQMLTSAGCSEKPPTVQHLEESFTNKCIVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVR1</accession>
    <name>A0A0D2PVR1_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G1932002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PVR1"/>
    <dbReference type="STRING" id="29730.A0A0D2PVR1"/>
    <dbReference type="Gramene" id="KJB31468">
        <property type="protein sequence ID" value="KJB31468"/>
        <property type="gene ID" value="B456_005G1932002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS06">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008507">
        <property type="entry name" value="DUF789"/>
    </dbReference>
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        <property type="entry name" value="T15D22.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31343:SF42">
        <property type="entry name" value="T15D22.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05623">
        <property type="entry name" value="DUF789"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="152" mass="17451" checksum="3BD094D68B95EBB8" modified="2015-04-29" version="1" fragment="single">MLGTGLEFRRVLPEDRFYNQAKARRSNLNQLSDQLRRAQCDVTSSQSNDKQAATHVNWQSEKRVDSTDLPKPVSVPSSESFTTMREWRMCDEEFQPYFMLGDLWESFKECSAYGAGVPLILNCLDSVVQYYVPYLSGIRIYADSLKRSTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PX00</accession>
    <name>A0A0D2PX00_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G100100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08736.1"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Wendel J.F."/>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KJB12589.1"/>
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        <property type="gene ID" value="B456_002G025600"/>
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        <property type="component" value="Chromosome 2"/>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PH_PLC_plant-like"/>
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    </dbReference>
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        <property type="entry name" value="PH, RCC1 and FYVE domains-containing protein 1"/>
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        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="BRX_N"/>
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        <property type="entry name" value="PH_domain"/>
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        <property type="entry name" value="Reg_chr_condens"/>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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    </dbReference>
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            <begin position="215"/>
            <end position="271"/>
        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="601"/>
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        </location>
    </feature>
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        <location>
            <begin position="947"/>
            <end position="1002"/>
        </location>
    </feature>
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            <begin position="671"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="923"/>
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        </location>
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        </location>
    </feature>
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            <begin position="798"/>
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        </location>
    </feature>
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            <begin position="759"/>
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        </location>
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        </location>
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            <begin position="925"/>
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            <begin position="1003"/>
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            <dbReference type="PROSITE" id="PS50178"/>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Google" id="ProtNLM"/>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0U6</accession>
    <name>A0A0D2Q0U6_GOSRA</name>
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        <recommendedName>
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    <gene>
        <name evidence="2" type="ORF">B456_006G000700</name>
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    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Pentapetalae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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            <begin position="25"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9463" checksum="6BF3AFDE3FDC720A" modified="2015-04-29" version="1">MATLIGNPLIKAFFIIFLVSAATATATATGDAPFIIAHKKASLNRLKSGAERVSVSVDIYNQGFTFYPDLPLIFQPKRKFYILNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q218</accession>
    <name>A0A0D2Q218_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G205300</name>
        <name evidence="11" type="ORF">Gorai_021586</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
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    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <taxon>malvids</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Reddy U.K."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="68085" checksum="598A57B0F5E41D90" modified="2015-04-29" version="1">MVREERVESFYARLRESARASSLSPLLIFPSTSDVDSLCALKIIFHILESDSVRYSCYPVSSFQEIREYAASELSSSSEEPVTLLLINWGCHRDLQEDLKLGSAARVFVVDSHRPIHLHNLSDQNDQVVVLYTNDDERLADLAYDFEVMELANASYCLHNSELDGEEDEDSESEDDDEDEEVEGRARDGSRKRRRLSSEGEEEPPARRFKKLKREYYRMGTFHGKPSGCLMYDLSHCLRKNTNELLWLACVSLTDQFVHERLTDERYEAGVMELQQHINSLGNLDAVTSVTLKDGTKVRAPDSSRIAYEEEPRLMLLREWNLFDSMLCSSYIAPKLKTWSDNGMKKLKLLLARMGFALVDCQQKFQYMNHEVKQKMKDQFEQILPEYGLDDFYYKSFLRLHGYTSRVSAADMVYGVTALLESFVQSDGLCALKQFGVAYDALSLSNLDKLKSGMQQAIKIQRAILRQGSAAITKSGCIRSGRKFRWVKLEDSVDTKLLGHPQALTKFCYFLMDALKEKGAKLKPLLCACMLQEPSKVLIVGVCGKPRLGALQGNAFGLAFRNAAEETGAEFFHELFESSWIVLDAGVVNSFMVKLTERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q3I4</accession>
    <name>A0A0D2Q3I4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histone deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_008G285500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:58197"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="4"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q3I4"/>
    <dbReference type="STRING" id="29730.A0A0D2Q3I4"/>
    <dbReference type="Gramene" id="KJB52932">
        <property type="protein sequence ID" value="KJB52932"/>
        <property type="gene ID" value="B456_008G285500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765623"/>
    <dbReference type="eggNOG" id="KOG1343">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09992">
        <property type="entry name" value="HDAC_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000014">
        <property type="entry name" value="Histone deacetylase 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB52932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="579" mass="63743" checksum="87F357ADA39CC91C" modified="2015-04-29" version="1">MVSETVQGSCVTNGGTKSNESFKRKHLGSDEHASASRHDSSDAKGDIGTSERDIAANINEDTQADDASKKVRLPKELTFQDMYNNQDAFDDDDEDDSDWEPVQKHIEILKWFCTNCTMVNLDDVFLCDICGEHKESGILRHGFYASPFSPEVELVQVESEATGREKEIWSEASASNCSTAVGFDERMLLHSEVEIKSHPHPERPDRLRAIAASLSAAGIFPGKCCLIPAREITLEELQMVHSSEHIEVVELTRQMFSSYFTPDTYANEHSAHAARLAAGLCADLASAIFSGRVRNGFALVRPPGHHAGVTQAMGFCLHNNAAVAALAAQAAGAKKVLIVDWDVHHGNGTQEIFDQNKSVLYISLHRHEGGKFYPGTGSAFEVGTKGAEGYCVNIPWSRGGVGDNDYIFAFQHVVLPIASKFAPDFTIISAGFDAARGDPLGCCDVTPAGYTQMTHMLSTLSGGKLLVVLEGGYNLRSISSSATAVIKVLLGESCECEPENVVPSKAGLLTVLEVLKIQMKYWPNLSSSFEKLQLQRAMYSVEKKQKQVKRRRVFEPPLWWRWGRKQLLFHILTGHFHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q4S8</accession>
    <name>A0A0D2Q4S8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-butyrobetaine hydroxylase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G267900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q4S8"/>
    <dbReference type="SMR" id="A0A0D2Q4S8"/>
    <dbReference type="STRING" id="29730.A0A0D2Q4S8"/>
    <dbReference type="Gramene" id="KJB11601">
        <property type="protein sequence ID" value="KJB11601"/>
        <property type="gene ID" value="B456_001G267900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769344"/>
    <dbReference type="eggNOG" id="ENOG502RZ9H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REQEMFA"/>
    <dbReference type="OrthoDB" id="19707at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35303:SF5">
        <property type="entry name" value="OS02G0197800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="3">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB11601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="148" mass="16833" checksum="44D58EEB10BFD2AD" modified="2015-04-29" version="1">MATRFRLVMAMQRTIQRIHSLVDTPRLKSFSLNAPKSVDVEYANGIKFSLSAEFLRVYSPAADGKIRSIGSEKVISGRRHVGIMSAEPVGNYGVRIVFDDLHKTGIYSWDYFFNLGSNKFTLMRNYIKTLKKHGLSRDPSKRKSSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8U3</accession>
    <name>A0A0D2Q8U3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G039600</name>
        <name evidence="3" type="ORF">Gorai_011051</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8U3"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8U3"/>
    <dbReference type="Gramene" id="KJB54577">
        <property type="protein sequence ID" value="KJB54577"/>
        <property type="gene ID" value="B456_009G039600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767627"/>
    <dbReference type="eggNOG" id="ENOG502QYAK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PAMSHEW"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005174">
        <property type="entry name" value="KIB1-4_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF7">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03478">
        <property type="entry name" value="Beta-prop_KIB1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB54577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0594133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="414" mass="46877" checksum="476F2C7103FEE58A" modified="2015-04-29" version="1">MEKANGCISRPSRKRKLPQEGNDVLNFTLDELSDDLLERVLSWLPTSTFFRFNLVCKRWKSVAASESFKLACSRIPSREPWFFMVDPNLNQSVVFDSVERSWKKLSHPPLLSQNCNCNSIPVAAAGGLVCFRNMSGDYFVCNPVTGSCRELPPVNPDSHHRSLHAIAMNAYSNYHGSYKLFLVSGDLPKLSYKVYNSSADCWEEEIMLRRKTDDCTGFDFDSNDDDDAVYFLSKAGNVVATNMQRSPSKQFSSVITHKDGEEIVYFLSSSGTVVACNLTQKHFSEYPRLLPVFLEYSIDVVECKGEMLVVMLSEFFESASIRVWRFDEKTKTWNQIAGMPPSMSHEFYGKKVDINCLGAGNQIFICLSSAELCSYFRCDIVTNEWVEVPKCCLNGEAMEFMSAFSFEPRIEASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCK4</accession>
    <name>A0A0D2QCK4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_002G136400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QCK4"/>
    <dbReference type="STRING" id="29730.A0A0D2QCK4"/>
    <dbReference type="Gramene" id="KJB14661">
        <property type="protein sequence ID" value="KJB14661"/>
        <property type="gene ID" value="B456_002G136400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2499">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HATDTQS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF21">
        <property type="entry name" value="BETA-HEXOSAMINIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
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        <property type="entry name" value="GLHYDRLASE20"/>
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        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
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    <feature type="chain" id="PRO_5002266151" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="535"/>
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            <begin position="30"/>
            <end position="146"/>
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        <location>
            <begin position="171"/>
            <end position="486"/>
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            <position position="329"/>
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        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB14661.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="535" mass="59915" checksum="7214E55816DA453F" modified="2015-04-29" version="1">MGKMGSEMLIYVLLLMAGVLASGQSSPVKIWPMPASVSYGHTHLYLTSDFGFSSNYGSEILKDAFDRMLALIKLDHVIDANFSAFNSSSLLQGLHIIISSPNGQLQYGVDESYKLIVPSPEKPAYAHLEAKTVYGALQGLQTFSQLCYFSVTSRVLQIDMSPWTIIDQPRFSYRGLLIDTSRHYLPVPVIKKVIDSMSYAKLNVMHWHIVDTQSFPLEIPSYPKLWDGAYSPSERYTVADAADIVSYAQKRGINVLAEIDVPGHALSWLSRNCSYSSLKGTGYPSLWPSKDCQQPLDISNEFTFKVIDGILSDFSKIFNFKFVHLGGDEVNTSCWTTTPRIRNWLKKHGMNESQAYQYFVLRAQNIALSHGYEIINWEETFNDFGNKLSRKTVVHNWLGGGVAQRVVASGLRCIVSNQDKWYLDHLDTPWQEFYANEPLTNITNLKQQKLVIGGEVCMWGETVDGSDIEQTIWPRAAAAAERLWTPFDKLAKNPRDVTGRLAHFRCLLNQRGVAAAPVAGLGRAAPEGPGSCYRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEZ5</accession>
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        <name type="scientific">Gossypium raimondii</name>
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            <taxon>Tracheophyta</taxon>
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    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ROH1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB56672"/>
        <property type="gene ID" value="B456_009G131400"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <source>
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        </source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40429" checksum="47F3B2DDE322A3E8" modified="2015-04-29" version="1">MDTQEQELEDIELFQKHVSDRFTELSSPPEDDALLSVSWLHRLLDVFLCCEAEFEAILIMDRDPSQLSKPPFDRLIPEFIERAVKALDICNAVANGVDSVRHCQKLSEIVISALDQNPLGDGHAKRAKKALLMLLSAMNLDDKEGTHVKATERSWSFGRRGVNKEQIAGHFRSLSWQVAKNWSSAKQIQSMMYNLVAPRGAEASGLPSPIYTMNVIMIFVMWALVAAIPCQERNGLPTHFPVPKQLNWAHSLIGLQEKIADEWKKKEKKGMSGLLDELQKMEKLAQSLIDFTDSFHFPGDAEKVKEAAANVSELKEIFGRMDQGLTPLQMHIREVFHRIVRSRTEFLDVLEKGSAPVV</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJ10"/>
    <dbReference type="SMR" id="A0A0D2QJ10"/>
    <dbReference type="STRING" id="29730.A0A0D2QJ10"/>
    <dbReference type="Gramene" id="KJB19644">
        <property type="protein sequence ID" value="KJB19644"/>
        <property type="gene ID" value="B456_003G111800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789855"/>
    <dbReference type="eggNOG" id="ENOG502RZX5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTHAGDW"/>
    <dbReference type="OrthoDB" id="581242at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04216">
        <property type="entry name" value="Phytocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000003">
        <property type="entry name" value="Blue copper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF70">
        <property type="entry name" value="PHYTOCYANIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220030" description="Phytocyanin domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB19644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0582425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="184" mass="19680" checksum="5A95E7AE835BFBD8" modified="2015-04-29" version="1">MAKLILLSLLAIFCFALTSHAATYVVGDTSGWDISTDIDSWATNKTFNVGDVLLFQYSSSHSVSEVNKESFETCNTTNSLTTFSNGNTTVTLSNAGKRYFVCGNKLHCLGGMKLQVNVLEDEKKSVTVGAPEAQPQPQATIPKPSSKTNNPSSTASDGFINGGIGSLIIAFLFMVSTMFGLFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLU9</accession>
    <name>A0A0D2QLU9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G164200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLU9"/>
    <dbReference type="STRING" id="29730.A0A0D2QLU9"/>
    <dbReference type="Gramene" id="KJB20774">
        <property type="protein sequence ID" value="KJB20774"/>
        <property type="gene ID" value="B456_003G164200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789175"/>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YECARDG"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009854">
        <property type="term" value="P:oxidative photosynthetic carbon pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12156">
        <property type="entry name" value="HPPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000213">
        <property type="entry name" value="Putative 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF268">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE HPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0323">Glycolate pathway</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="48"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="121"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB20774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35343" checksum="B58EFF95242E33F5" modified="2015-04-29" version="1">MADKEAQQPEELPVVFLHRPPSFILPFGDHLRSQFHVLDPYESPEPYDSFLARHAPSIRALMTMGPALVSAEFLDRLPVLELIVATSAGLDHVDLPACRSRGIVVTNASSAFAEDVADCAVGLLIDVLRRISAADRFVRGRMLPVKETYPLGFKLGGKRVGIVGLGSIGSEVAKRLSAFGCTIAYTSRNKKQSVPFLFYANVRDLAANSDVLVLCCALTKETYHLVNKDVMVALGKEGVIINVGRGSLINEKELVQCLVGGEIGGAGLDVYENEPNVPKELFGLDNVVLSPHSAGGTPEGFEAVLQLTVGNLRAFFSNKPLVSEVSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QN43</accession>
    <name>A0A0D2QN43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G072100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QN43"/>
    <dbReference type="STRING" id="29730.A0A0D2QN43"/>
    <dbReference type="Gramene" id="KJB40638">
        <property type="protein sequence ID" value="KJB40638"/>
        <property type="gene ID" value="B456_007G072100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQUD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHPMMFT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753:SF34">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22753">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="5">
        <location>
            <begin position="172"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB40638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="724" mass="81740" checksum="24A7ADEEE0EE53F5" modified="2015-04-29" version="1">MAAISASTYPAAGVSPFSQRRATSSYRGIRNLSRILAVSTERGGRGTGFGENGKHEKQKLNQKVVKEESEVKPNIYANPEKIPEFEEDKKWLRDYFEECKEMIRSDGGPPRWFSPLECSSSTSPDCPLLLFLPGIDGTGLGLIMHHHKLGKMFNVWCLHIPVQDRTPFNELVKIVERTVRSENYRSPNRPIYLVGESIGACLAISVAARNPDMDLVLVLSNPATSFSQSQLQPLIPLLEMMPDQFPINLPYIFSLATSYFANMLLNFLGCISNSNPLRVLMDNVVKRGPLPQIIGELSQDLATMSSYLPVLADTVPRQTLLWKLNLLKSGSACGNSCLHAVKAQLLILCSGRDQLLPSQEESQRLQKALPDCEIRMFEESGHFLFLEDNVDLVTIIKGASFYRRGKHFDCASDFMPPTPSEFKKLHDSISWVLTATSPVMLSTLEDGKVVRGLAGIPSEGPVLFVGYHMLMGFEVIPLVAQIMMERNILVRGIAHPAMFVRVKDRRPPEPELSDFDVIRVMGAVPVSAANFYKLMSSKSHALLYPGGVREALHRKGEEYKLFWPDKSEFVRMAARFGAKIIPFGVVGEDDFAEIILDYNDLMKIPWRREEIERVTSRTAKLRTDASGEIANQQMHIPWVLPKFPGRFYYYFGKPILTEEMKVELREKKKCDEMYLHIKSEVEGCIDFLKNKREKDPYRNLLSRVLYQASHPGSTSPFHLPSFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNS9</accession>
    <name>A0A0D2QNS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G268200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNS9"/>
    <dbReference type="STRING" id="29730.A0A0D2QNS9"/>
    <dbReference type="Gramene" id="KJB59712">
        <property type="protein sequence ID" value="KJB59712"/>
        <property type="gene ID" value="B456_009G268200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770002"/>
    <dbReference type="eggNOG" id="KOG0363">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKMDIEH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000025">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB59712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="527" mass="57130" checksum="D81EC7D52BEBBF18" modified="2015-04-29" version="1">MAIEKILKDDASEEKGERARMASFVGAIAITDLVKTTLGPKGMDKILQSTGRGHEVTVTNDGATILKSLHIDNPAAKVLIDISKVQDDEVGDGTTSVVVLAGELLREAEKLVAAKIHPMTIISGYRMAAECARNALLQRVMDNKGNAEKFKSDLMKIARTTLSSKILSQDKEHFAQLAVDAVMRLKGSTNLEAIQIIKKPGGSLKDSFLDEGFILDKKIGLGQPKRIENAKILVANTAMDTDKVKIYGARVRVDSMSKVAEIEGAEKEKMREKVKKIIAHGINCFVNRQLIYNFPEELFADAGILAIEHADFDGIERLALVTGGEIASTFDNPESVKLGHCKLIEEIMIGEDKLIHFSGVEMGQACTVVLRGASHHVLDEAERSLHDALCVLSQTVNDTRVLLGGGWPEMVMAKEVDELARKTPGKKSHAIEAFSRALVAIPTIIADNAGLDSADLVAQLRAEHHKEGCNAGIDVISGSVGDMAELGISESFKVKQAVLLSATEAAEMILRVDEIITCAPRKREDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRN0</accession>
    <name>A0A0D2QRN0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G172400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="CRM" evidence="9">
        <location>
            <begin position="153"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="CRM" evidence="9">
        <location>
            <begin position="273"/>
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        </location>
    </feature>
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        <location>
            <begin position="31"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB09880.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="389" mass="44998" checksum="F230C3D0058C6D29" modified="2015-04-29" version="1">MTLTRLSRQKPPSLFITVRFLTRHLSTSKLRDHYSFQPPPSLSLDPQKSKSNPNSHKKQKPKYRPPSSLDQIKPIYSDLPFDFRFSYTESSPTVRPIGLREPKYSPFGPGRLDREWTGVCAPAVDPKVKSLEGTEDPNLEAKRKLLRGRIQGAPLTEAERKFLVEKCQRNRNKRQINLGRDGLTHNMLNDIHNHWKFAEAVRIKCLGVPTVDMKNVCKQLEDKTFGKIIQRHGGTLILYRGRNYNRKKRPVIPLMLWKPQEPVYPRLIKTTIDGLSIEETKEMRKRGLAVPALTKLAKNGYYGSLVPMVRDAFVVSELVRIDCMGFERSDYKKIGCKLRDLVPCILVTFEKEQIVVWRGQDYKPPEDGHFFTDREFFDDPGCDMERSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSL6</accession>
    <name>A0A0D2QSL6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">RRP15-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G190100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:maturation of 5.8S rRNA"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
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            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB10225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33226" checksum="BB1EE581D3D31B17" modified="2015-04-29" version="1">MMMEEGSTAVGKRKRNMGKKKGKKPKNKKLKMLEGKGKKLRLSKKMRNLFEKRARQYNSDDDEEEREEGEEALGDTRIGRGDDNSSEENDGSEEVEIQPGVMKFTDGVRAFRLAFKNIIKRNVADDSLGPVLSGHKQLVAKKLAEEEAERKVKGEAKKEKHLVAEKGHFKPANYLDSHEKFLIGIATKGVVKLFNAVNKAQKAQKGLDPSRSKDAKVIRRRRKEAFFSELGKTSRDSSSKGNTSSDPRNEEEPAWAPLRDNYMLTNPKLKNWDKTAEAGIADDAGRMSEDSGSDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXT6</accession>
    <name>A0A0D2QXT6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G227200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXT6"/>
    <dbReference type="Gramene" id="KJB43973">
        <property type="protein sequence ID" value="KJB43973"/>
        <property type="gene ID" value="B456_007G227200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="197" mass="22912" checksum="046FD1C1162D1175" modified="2015-04-29" version="1">MIPTTQTDCSIPKHLKSKTFQQPIRVLSHQSYQSASIIYWKVFFQKPLRLFKILALFHLKSPKNSFSNYFLPLFQNGEPISDVACTMWLSPIYFNSIKCIDYESRTSNLLRLLHLENPFKLLSKPSRSKLSPLLQNGEGMLACKTVFEQRILPMSFLITIPKSRSIIFLAKSCIKIYFDKRVLRHLPHTNGRSLPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYA4</accession>
    <name>A0A0D2QYA4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G006900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYA4"/>
    <dbReference type="STRING" id="29730.A0A0D2QYA4"/>
    <dbReference type="Gramene" id="KJB12210">
        <property type="protein sequence ID" value="KJB12210"/>
        <property type="gene ID" value="B456_002G006900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773102"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQIDISC"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14665">
        <property type="entry name" value="STKc_SnRK2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000085">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000045">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF509">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="360" mass="40992" checksum="1728DD1C831EE76F" modified="2015-04-29" version="1">MDRPAMGAGMDLPIMHDSDRYELVKDIGSGNFGVARLMRDKHTDELVAVKYIERGEKIDENVQREIINHRSLRHPNIIRFKEVILTPTHLAIVMEYAAGGELFERICNAGRFSEDEARFFFQQLISGVSYCHSMQVCHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSQPKSTVGTPAYIAPEVLLKKEYDGKVADVWSCGVTIYVMLVGAYPFEDPEDPRNFHKTIHRIIHVQYSIPDYVHISPECRHLISRIFVADPAKRISIPEIKNHEWFLKNLPADLMDENSMNDQFEEPDQPMQSVDEIMQIISEATIPATNMNNLDSYLTGSLDPDDDMEDLDNDSELDIDSSGELIYAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0T5</accession>
    <name>A0A0D2R0T5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G025600</name>
        <name evidence="5" type="ORF">Gorai_007005</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0T5"/>
    <dbReference type="SMR" id="A0A0D2R0T5"/>
    <dbReference type="STRING" id="29730.A0A0D2R0T5"/>
    <dbReference type="Gramene" id="KJB63942">
        <property type="protein sequence ID" value="KJB63942"/>
        <property type="gene ID" value="B456_010G025600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774144"/>
    <dbReference type="eggNOG" id="ENOG502QVRR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSCVIQT"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000042">
        <property type="entry name" value="probable strigolactone esterase DAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43039">
        <property type="entry name" value="ESTERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="21"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB63942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0597190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="266" mass="29383" checksum="A7E70DB5D264D133" modified="2015-04-29" version="1">MANTLLEALNVRVVGSGDRILVLAHGFGTDQSVWQRILPFFTPNYRVILYDLVCAGSVNPDYFDSTRYDTLDAFVDDLLNILKALGVHRCAYVGHSVSAMIGILASIRCPQLFSKLILIGASPRFLNDENYHGGFELGEIEEVFSAMEANYEAWVNGFAPVLVGADVPTAVREFSRTLFNMRPDISLFVSRTIFNSDLRGELGKVRVPCCVIQTAKDVSVPASVAEYLKTRLGGRTTVEILRTEGHLPHLTAPVLLAQVLRRALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R118</accession>
    <name>A0A0D2R118_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VTT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G204000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R118"/>
    <dbReference type="STRING" id="29730.A0A0D2R118"/>
    <dbReference type="Gramene" id="KJB25679">
        <property type="protein sequence ID" value="KJB25679"/>
        <property type="gene ID" value="B456_004G204000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792134"/>
    <dbReference type="eggNOG" id="ENOG502QV3G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202840at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46431">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46431:SF7">
        <property type="entry name" value="SNARE ASSOCIATED GOLGI PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="2">
        <location>
            <begin position="132"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB25679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="308" mass="34463" checksum="32BE6DB056940AD5" modified="2015-04-29" version="1">MTFYDGNSNGEGGEVMPELKVRVEGDDNGVNGKRVTLRQRLLEECEAEERYLLVKEPAFSCIQRRSIWFWVKLGVLFTFIGLLAAVFFRWVGPFLMDKELMPIINWEMTTFSTPMLAVLVFASVALFPTILLPSTPSIWVAGMTFGYGFGFLLIISAAAVGVSLPFFIGSLFLHRIQGWLEKYPKKAAILRAAGEGNWFHQFKAVTLIRISPFPYIIYNYCAVATHVKYGPYILGSLIGMVPEIFVAIYTGILIQTLADASQEQHTLSAPQILLNVGGFLLTVVTTIVFTVYAKRQLKVLQGEELILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3U7</accession>
    <name>A0A0D2R3U7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G342100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R3U7"/>
    <dbReference type="STRING" id="29730.A0A0D2R3U7"/>
    <dbReference type="Gramene" id="KJB45988">
        <property type="protein sequence ID" value="KJB45988"/>
        <property type="gene ID" value="B456_007G342100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGPRCQM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001860">
        <property type="entry name" value="Sucrose nonfermenting 4-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="345"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB45988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="52886" checksum="586A61DFC33279E0" modified="2015-04-29" version="1">MFASAPDSGNGNSGVSRSLLIPMRFVWPYGGSRVFISGSFTRWSEHIPMSPMEGCPTVFQVICSLSPGYHQFKFFVDNEWRHDEHQPFVIGDYGVVNTIFIAREQDMLPPSFSPEMPGRSNMDLDDVSSQMEAAPTISNADLEVSRHRIAAFLSRHTAYELLPESGKVVALDVDIAVKQAFHILHEQGIPVAPLWDSCKGQFVGVLSALDFILILRELGNLGSDLTEEELEMHTISAWKEGKVHISRQMDGNARSYPRRLVCAGPHDSLKDVALKILNGKVATVPITHSSSPDGSFPQLLHLATLSEILKCICRHFKHSSSSLPILQQPICSIPLGTRVPKIGESNRRPLAMLRPNASLGAALSLLVQAEVSSIPIVDENDALIDIYARSDITTLAKDKAYAQIRLDEMSIHQALQLEQDANSFNGQRCQMCLQSDTLHKVMERLANPGTRRLVIVEAGSKRVEGIISLSDVFRFLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R536</accession>
    <name>A0A0D2R536_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_004G272900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R536"/>
    <dbReference type="Gramene" id="KJB27029">
        <property type="protein sequence ID" value="KJB27029"/>
        <property type="gene ID" value="B456_004G272900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792824"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VGCGHLF"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF9">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB27029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="178" mass="20153" checksum="9B203B1BBA357230" modified="2015-04-29" version="1">MPPPPPLPPQSSPTGGSTSTPSKSKEKFLSLILKAIIMMLLISFFFLILPLASFLLLLPLLLRHRRHRHRRHHLHPSSGFSSKQLKKLPQFRFSHETESVGSDSDSCVICLDGFRQGQWCRSLVGCGHLFHRKCLDGWLIKVAACPICRTRVRFENEDNCNSGPCCSRRAEFQGLFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9A9</accession>
    <name>A0A0D2R9A9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G047200</name>
        <name evidence="4" type="ORF">Gorai_016071</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9A9"/>
    <dbReference type="Gramene" id="KJB28424">
        <property type="protein sequence ID" value="KJB28424"/>
        <property type="gene ID" value="B456_005G047200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796704"/>
    <dbReference type="eggNOG" id="ENOG502S4P0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRKMVGT"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB28424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0585290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="330" mass="37248" checksum="17442E45F2316241" modified="2015-04-29" version="1">MDPPPITLLMVQGPRKDETFVFHPGSAIRIGRVMRGNNLPIKDAGISSKHLTIESVSGKWILRDIGSSNGTTLNSNVLPAETAFDLHDGDTVKLGETTSILIKIEGSGGSGEEVAVVVESRRKNPPRRGKAAKNETGSSNKELENLELEKKENVRVTRSRKNEDSQNCRLDIPKVPENREAAAKRGKGRRGGRKKNEQEEKLEQKETKLTENDDTLIIKEEVDKEEEALNPLQNEEIQVRNDEENVEHSKIGVKESCDEMENEVRESCDERVEVDLEKMTLRQWFDYLEVHLPKQILEATEEMIEGMRKKAQKVQEYMVEQKKKGKAAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RC77</accession>
    <name>A0A0D2RC77_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SKP1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G089800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a SCF (SKP1-cullin-F-box) protein ligase complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SKP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RC77"/>
    <dbReference type="STRING" id="29730.A0A0D2RC77"/>
    <dbReference type="Gramene" id="KJB48838">
        <property type="protein sequence ID" value="KJB48838"/>
        <property type="gene ID" value="B456_008G089800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009867">
        <property type="term" value="P:jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="6"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="5">
        <location>
            <begin position="93"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB48838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="159" mass="18572" checksum="7E5B86BC25BD25D2" modified="2015-04-29" version="1">MESTSKKVTLSSSDGWTFEVEEAVAFQSQTIKHLYETGYTDDFIPVPNVTGDILSMESFYDNKLKHWDAFFVKVDQSILFDLILVADFMNIISLMDLTCKTVANMMKGKTTKEIRGTFNIKKDYTPEAEEMLRKECRYYQRLDWATMKVWKIWNPAPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RD71</accession>
    <name>A0A0D2RD71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G104600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="8"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RD71"/>
    <dbReference type="STRING" id="29730.A0A0D2RD71"/>
    <dbReference type="Gramene" id="KJB49173">
        <property type="protein sequence ID" value="KJB49173"/>
        <property type="gene ID" value="B456_008G104600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGRINSW"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000073">
        <property type="entry name" value="Trehalose 6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000099">
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD-SF_hydro_IIB"/>
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    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF3">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
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    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00000500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB49173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="376" mass="42486" checksum="0E5A1A4EE1DB03A5" modified="2015-04-29" version="1">MVSFFEDSAKNIAGKNVMFTDAKSVLNMSITVTVSAQNPLASPGYKISIKTKKLLQNREIISGARVNAWVDSMRASSPTHTKSTSSVTDDQVTWNLHHPSALEMFEQIIDASKGKQIVMFLDYDGTLSPIVEDPDRAFMSKKMRKTVRKLAKCFPTAIVSGRCRDKVYKFVKLAELYYAGSHGLDIKGPEKRSKSKSDGESVLFQPASEFLPMIDEVYKQLVDTTKSTPGAKVENNKFCLSVHFRCVDEKKWSELAQQVRSVLKEYPKLRLTQGRKVLEIRPTIKWDKGKALEFLLESLGFANCTDVFPVYIGDDCTDEDAFKILRDRGQGFGILVSKFPKETSASYSLQEPDEVMDFLRRLVEWKQLSLQAQSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF97</accession>
    <name>A0A0D2RF97_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">HTH-type transcriptional regulator protein ptxE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G019100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="KJB17850.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="162" mass="17613" checksum="9A866DD1FCC13E74" modified="2015-04-29" version="1">MGICSSCESTQITTAKLILQDGRLQEFPYPVKVSYVLQRNPMCFICNSDEMDFDDVVSAIEEDEELQPGQLYFALPLTWLKHPLQAEEMAALAVKASSALMKSGGCGGEKSGLRRKTVIPFEFSCESPRRKVGSGVGCGGGKRGGRGKGRRKFTAMLSAIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFR3</accession>
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        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
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        <name evidence="8" type="ORF">B456_011G023800</name>
        <name evidence="9" type="ORF">Gorai_005197</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0598955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB69432">
        <property type="protein sequence ID" value="KJB69432"/>
        <property type="gene ID" value="B456_011G023800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774920"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PDILFHE"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000349">
        <property type="entry name" value="Transcription factor MYB39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994">
        <property type="entry name" value="F14D16.11-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994:SF5">
        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB69432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0598955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="315" mass="35605" checksum="B770E6A58168C927" modified="2015-04-29" version="1">MGRTPCCDKNGLKKGPWTPEEDQKLIDYIQSHGYGNWRTLPKNAGLQRCGKSCRLRWTNYLRPDIKRGRFSFEEEEAIIQLHSVLGNKWSAIAARLPGRTDNEIKNYWNTHIRKRLLRMGIDPVTHSPRLDLLDLSSILGCCSFYNQSQMNMSTRLLGGGGGVQPLVNPEILRLATSIMSSPQRENQNPDILFHENQYQQSPLMQNTNVAEPVMNNNPNVIIDQFPFNGCFTDWQNNANAVLPYLTEDNYVPVPSNCYGGGNGEPSFRTPSSSSPTPLNSNNSTYINSSSTEDESYSSDILKFEIPDFLDVNEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIS9</accession>
    <name>A0A0D2RIS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G2008001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIS9"/>
    <dbReference type="Gramene" id="KJB51092">
        <property type="protein sequence ID" value="KJB51092"/>
        <property type="gene ID" value="B456_008G2008001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB51093">
        <property type="protein sequence ID" value="KJB51093"/>
        <property type="gene ID" value="B456_008G2008001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000004">
        <property type="entry name" value="WRKY transcription factor 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046829">
        <property type="entry name" value="Calmod_bind_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046830">
        <property type="entry name" value="Calmod_bind_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018872">
        <property type="entry name" value="Zn-cluster-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31282">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20452">
        <property type="entry name" value="Calmod_bind_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20451">
        <property type="entry name" value="Calmod_bind_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10533">
        <property type="entry name" value="Plant_zn_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="502"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB51093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="576" mass="64451" checksum="A217F286D1E04AB4" modified="2015-04-29" version="1" fragment="single">YGDVFQASIQDEGAHPDLAPDDGFCWRKYGQKDILGAKYPRRYYRCTYKHNQGCLATKTVKRSSDDPTIFEITYRGKHTCNLASNVMPPTAPSEYQEQGTRIEPQQQHNQLTEENQKQQSQDLLVLPSTPGQCVEQSFNQKSNSGNDHLTITHEDNNSTIVCQESSPSPSDSSSMGSQLSAAALSTEQLQAQRFDEPAKQNQLYKKHYPPMLGDEVWRLDRIDKNGIIHKRLASEGINTVQDFLKMWVVNPGELRRILGPIMSERKLDHAINHARTCVMGNKYYVFRGSNYRILLNPICQLMGAEVNGSIYPTHSLSNIDTVYLEKLVRQAYVNWSSLEEIEGISNEIIGPLTQDIMAQRTGANVINTIPSNLRAMPPSGPWLPELPDHPVLMDNSNVLSSPTTGECAVQYLNQKNNSGNDQQTISQEDNNSTIVCQVPPPSQSNSSAMTSELSATALPTGSDLIQSRAPADAHSWHCYGTKGKKRKHRVKRSIKVPSIGNKLVDIPPDDYSWRKYGQKPIKGSPYSRGYYKCSSMRGCPARKHSERCLEEPSMLIVTYEGEHNHPKLPSRATTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQ81</accession>
    <name>A0A0D2RQ81_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G0861003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQ81"/>
    <dbReference type="STRING" id="29730.A0A0D2RQ81"/>
    <dbReference type="Gramene" id="KJB21265">
        <property type="protein sequence ID" value="KJB21265"/>
        <property type="gene ID" value="B456_004G0861003"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21266">
        <property type="protein sequence ID" value="KJB21266"/>
        <property type="gene ID" value="B456_004G0861003"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="PICBP-like"/>
    </dbReference>
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        <property type="entry name" value="CALMODULIN-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33923:SF2">
        <property type="entry name" value="CALMODULIN-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07839">
        <property type="entry name" value="CaM_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01054">
        <property type="entry name" value="CaM_binding"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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            <begin position="492"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
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        </location>
    </feature>
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            <begin position="257"/>
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        </location>
    </feature>
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            <begin position="484"/>
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        </location>
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        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="72"/>
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            <begin position="102"/>
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            <begin position="520"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB74417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="602" mass="66918" checksum="BB3D62DB7A7605EC" modified="2015-04-29" version="1">MVQRKVTNKLEIGVQADHHIDGKNKGTGLKKKMKKCRSIKLSDMKEGLRSSSPLVSRKTISPPVKPSPPPHNNSRSIIKGASSGSPNYMKSTSSSEAKKETSASSQVSSRRKSSASGLTRTSSLKLTKTPSFKPVRASAKKCSKVALRSDMNVQKATCSSTLKDSKFPAYLMLNPGGTEYEGTSIVKVCSYTYCSLNGHHHAPLPPLKCFLKARRRSMKVQRSMKVEALSPRKACGDGTEELNSSMDFFVEIYGKSKGEDSSECGNETAPEPETESRGSLNAEIDFGENVEHGSEVVSQVDTSENEEFRGISAKEESSPWSFNDGDKQEGDWSADMDDTMFEVIDLEWDEWPFSASQSGDEACSAIESDTSMEYSSETVRNDMTEEGVTDDNECTNDIDTCSQVSETLCYDLVLATTIDEEHGERTSGKEEMLENGVPATINEVFEVDSTFEVPSSEIRDKTGNVDVAGLLVEVNDAIDQTLEEHEDAADGDTRHKPRSKAIANEELPEKHTTKWTIGHGRHDENNDELKTFNPREPNFLSVVPETDKEKVDLRHQMMEERRNAEEWMLDHALQQAVTKLGPAKKRKWHYLLKLLKQSYHCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVW6</accession>
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        <submittedName>
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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            <begin position="1"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="KJB23260.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="84" mass="9495" checksum="2E83B5126B0C5983" modified="2015-04-29" version="1">MKPQSLSGDNNSNNNSVMAESKGRMMIRERVKQACEAAMDAMAKKGVQRGHRVLISKEIERRNGSHYADEPIRTMMFLGSWSHT</sequence>
</entry>
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    <accession>A0A0D2RWN2</accession>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB75157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A0D2RWN2"/>
    <dbReference type="STRING" id="29730.A0A0D2RWN2"/>
    <dbReference type="MEROPS" id="I03.030"/>
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        <property type="protein sequence ID" value="KJB75157"/>
        <property type="gene ID" value="B456_012G027600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781070"/>
    <dbReference type="eggNOG" id="ENOG502QWSQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1872570at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="beta-trefoil_STI_VvMLP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kunitz_inhibitor_STI-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Prot_inh_Kunz-lg"/>
    </dbReference>
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        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33107:SF5">
        <property type="entry name" value="KUNITZ TRYPSIN INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KUNITZINHBTR"/>
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        <property type="entry name" value="STI"/>
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    </dbReference>
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        <property type="entry name" value="STI-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266891" evidence="1">
        <location>
            <begin position="20"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="198" mass="21849" checksum="D37054BA0D420340" modified="2015-04-29" version="1">MKTGLFLALSFILCASGSAAPDPVLDISGKMLRTGNDYYILPVFRGRGGGLTLASTGNETCPLHVVQEQLEVSNGLPVTFSPFNIKKGVIRVSTDHNIKFSAATICVQSTVWKLANFDDSTRQWFLTSGGVEGNPGRQTIDNWFKIEKHEDDYKLVFCPTVCDFCKVMCRDVGVFIDDAGVRRLALSDVPFKIMFKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RX78</accession>
    <name>A0A0D2RX78_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Late embryogenesis abundant protein ECP63-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G159500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RX78"/>
    <dbReference type="Gramene" id="KJB36459">
        <property type="protein sequence ID" value="KJB36459"/>
        <property type="gene ID" value="B456_006G159500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799719"/>
    <dbReference type="eggNOG" id="ENOG502R2QW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKGREMK"/>
    <dbReference type="OrthoDB" id="1907061at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009631">
        <property type="term" value="P:cold acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1430">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004238">
        <property type="entry name" value="ECP63-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47877">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT DOMAIN-CONTAINING PROTEIN / LEA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47877:SF4">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT PROTEIN ECP63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02987">
        <property type="entry name" value="LEA_4"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Late embryogenesis abundant protein ECP63-like" evidence="2">
        <location>
            <begin position="249"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein ECP63-like" evidence="2">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein ECP63-like" evidence="2">
        <location>
            <begin position="337"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Late embryogenesis abundant protein ECP63-like" evidence="2">
        <location>
            <begin position="381"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB36459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="569" mass="62948" checksum="1A89470018095934" modified="2015-04-29" version="1">MATRQEKERRAEAAARQAADDLRDINSGREYEERVVYKEELDRSSQQQQQRLPEESFAYKEEWGRETSPQQQQQRPGVIGTVLRAVQGTYEHAKEAVVGKSHEREGVYGGGGKTWGTTDEGDNAKEFAERAKDTTMEKAGEYKDYASEKAYQSADKAKQMKDTTKEKAAEYTDYAAQKAKETKNSAAQRTKETKDTVTGKASEYTDYAAQKAKDAKDTTAKKASEYTDYAAQQTKGAKDATTGKATEYKDYTAEKAKEARDTTAQKASEYTDYAAQKAKDAKDTTAQKASEYTGYAAQKTKDAKDATMGKATEYKDYTAHKAKEARDTTSQKASEYTDYAAQKAKDAKDAAIGKATEYKDYAAEKAKGAKDTAAQKASELTDYAAQKAKEAKDTTMEKATEYKDYAAEKAKEAKDVTAEKTKQGTEYATEKAKEGKDTTVSKLGELKDSAADAAKRAMDFLTGKTEETKQKASETAQNTRETLSETTESARQKMEEMKLRGDEGRRKTYDDDVKRQGREGHSETIVIKVEESPAGAVDATVRSSDETFNDVGRVGEEGVIRDRSSKTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S183</accession>
    <name>A0A0D2S183_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KARI N-terminal Rossmann domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G234000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S183"/>
    <dbReference type="STRING" id="29730.A0A0D2S183"/>
    <dbReference type="Gramene" id="KJB38044">
        <property type="protein sequence ID" value="KJB38044"/>
        <property type="gene ID" value="B456_006G234000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB38044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="67" mass="7164" checksum="05639540477D155E" modified="2015-04-29" version="1">MLLPDAFKGIKQIGVIGWGSQGPAQAQNLRDSLADAKSNIIVQVYVVIRNSNSAEIAAEENGCDHKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SCF3</accession>
    <name>A0A0D2SCF3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G1296001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SCF3"/>
    <dbReference type="STRING" id="29730.A0A0D2SCF3"/>
    <dbReference type="Gramene" id="KJB41954">
        <property type="protein sequence ID" value="KJB41954"/>
        <property type="gene ID" value="B456_007G1296001"/>
    </dbReference>
    <dbReference type="OMA" id="YICRILY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB41954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="51" mass="6186" checksum="1F75E62C16D9F94F" modified="2015-04-29" version="1" fragment="single">TFTMQPLPLRAAQDLIRFLHQPVYHSQRFKLWLSYFEIYGGKLFDLLSDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SFS9</accession>
    <name>A0A0D2SFS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein PLASTID MOVEMENT IMPAIRED 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G184500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WEB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SFS9"/>
    <dbReference type="STRING" id="29730.A0A0D2SFS9"/>
    <dbReference type="Gramene" id="KJB43114">
        <property type="protein sequence ID" value="KJB43114"/>
        <property type="gene ID" value="B456_007G184500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803609"/>
    <dbReference type="eggNOG" id="ENOG502QR0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DASMECK"/>
    <dbReference type="OrthoDB" id="685331at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009904">
        <property type="term" value="P:chloroplast accumulation movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009903">
        <property type="term" value="P:chloroplast avoidance movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008545">
        <property type="entry name" value="Web"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054">
        <property type="entry name" value="HEAVY CHAIN, PUTATIVE, EXPRESSED-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32054:SF2">
        <property type="entry name" value="PROTEIN PLASTID MOVEMENT IMPAIRED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05701">
        <property type="entry name" value="WEMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="127"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="270"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB43114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="67741" checksum="7DA50D608FF304C8" modified="2015-04-29" version="1">MEKRRIGSSKVAVNMYEEMILDGNSSVKKPQSQQAFPEKPLSKARELHIARRDMSRYKESRRIAESETFKAESELSSAKKTVKDLASMIEESNFKAKERIKDVESLKKKGKLDVKASVFRCVESYQCVEVMEELEMVKHELSELKLAMASVMADKERAVKEFEDSSKKLLSNGKHIEELRKEIEVANEEHVLVELAKMEASKEAADIEAQKEKEVGELSCRMAGTKKKMEDMINEIDQTGELEQRLTVTLSDINVLQDELKQVKDQPPSLESTNKVLQAAKNELASIREEGFRYMSSMDVIRNELKHVIEETKKLKKTEEKTDLRVKSLNSKLLRAKSKLEAATAAEEKANSIVANLSLSLEQLRLEAEASTKEKALIAEEAAAIAEEIRKTESKIDSTEEKLQAAVGELEAVKSAETSALEKLRSLIETTMLSRASASDRNSTITISKFEYEYLTGRAVGAEDIADKKVAAAQAWIEALKASEREILIKTKMAQSDLKEMRVEEEEEEYRTQRSLSAKKMIEKELRNWQLVEQNKQSSFNRRSMKSNGNSTPLGKSKFRRSLSPAIRVSGLTPFSIKKKKKGMPNLAKLFTGKKVDKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SH69</accession>
    <name>A0A0D2SH69_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G097400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SH69"/>
    <dbReference type="Gramene" id="KJB41286">
        <property type="protein sequence ID" value="KJB41286"/>
        <property type="gene ID" value="B456_007G097400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802675"/>
    <dbReference type="eggNOG" id="KOG1700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GICHRCE"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09440">
        <property type="entry name" value="LIM1_SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000002">
        <property type="entry name" value="LIM domain and actin-binding 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24206">
        <property type="entry name" value="OS06G0237300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0440">LIM domain</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="8"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="10">
        <location>
            <begin position="103"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB41286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="209" mass="23331" checksum="ED62B45DB45A5CCA" modified="2015-04-29" version="1">MAFTGTLDKCKACDKTVHVVDMMTLEGVPYHKTCFKCSHCKGNLVMNTYSSMDGVLYCKPHFEQLFKESGNFSKNFQTAKTEKQNDTSRTPNKLSSLFSGTQDKCAACEKTVYPLEKITMEGECFHKTCFRCAHGGCPLTHSSYAALNGILYCKHHFAQLFMVKGNYNHVLQSATHRRNTSTASSTDFAENQADLETAAANQDDNEEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHU9</accession>
    <name>A0A0D2SHU9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">atp1</name>
        <name evidence="23" type="ORF">B456_013G213000</name>
        <name evidence="22" type="ORF">GraM_p10</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <geneLocation type="mitochondrion" evidence="22"/>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="22" key="2">
        <citation type="journal article" date="2017" name="Plant Biol." volume="19" first="484" last="493">
            <title>Entire nucleotide sequences of Gossypium raimondii and G. arboreum mitochondrial genomes revealed A-genome species as cytoplasmic donor of the allotetraploid species.</title>
            <authorList>
                <person name="Chen Z."/>
                <person name="Nie H."/>
                <person name="Grover C.E."/>
                <person name="Wang Y."/>
                <person name="Li P."/>
                <person name="Wang M."/>
                <person name="Pei H."/>
                <person name="Zhao Y."/>
                <person name="Li S."/>
                <person name="Wendel J.F."/>
                <person name="Hua J."/>
            </authorList>
            <dbReference type="PubMed" id="28008701"/>
            <dbReference type="DOI" id="10.1111/plb.12536"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites.</text>
    </comment>
    <comment type="function">
        <text evidence="17">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 18">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
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        <property type="protein sequence ID" value="AMT85454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A0D2SHU9"/>
    <dbReference type="STRING" id="29730.A0A0D2SHU9"/>
    <dbReference type="Gramene" id="KJB82787">
        <property type="protein sequence ID" value="KJB82787"/>
        <property type="gene ID" value="B456_013G213000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1353">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCGVKGY"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 17" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6 15" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9 15" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 22" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="21">
        <location>
            <begin position="31"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="19">
        <location>
            <begin position="155"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="20">
        <location>
            <begin position="386"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="AMT85454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB82787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="511" mass="55629" checksum="C2EDA8197C12CA2A" modified="2015-04-29" version="1">MELFMEFSPRAAELTTLLESRITNFYTNFQVDEIGRVVSVGDGIARVYGLNEIQAGEMVEFASGVKGIALNLENENVGIVVFGSDTAIKEGDLVKRTGSIVDVPAGKAMLGRVVDALGVPIDGRGALSDHERRRVEVKAPGIIERKSVHEPMQTGLKAVDSLVPIGRGQRELIIGDRQTGKTAIAIDTILNQKQMNSRATSESETLYCVYVAIGQKRSTVAQLVQILSEANALEYSILVAATASDPAPLQFLAPYSGCAMGEYFRDNGMHALIIYDDLSKQAVAYRQMSLLLRRPPGREAFPGDVFYLHSRLLERAAKRSDQTGAGSLTALPVIETQAGDVSAYIPTNVIPITDGQICSETELFYRGIRPAINVGLSVSRVGSAAQLKAMKQVCGSLKLELAQYREVAALAQFGSDLDAATQALLNRGARLTEVPKQPQYSPLPIEKQILVIYAAVNGFCDRMPLEKISQYERAIPKSIKPQLLQSLLEKGANERKIEPDTFLKESALPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLM9</accession>
    <name>A0A0D2SLM9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, chloroplastic/mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">GATA</name>
        <name evidence="9" type="ORF">B456_N008100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Plastid</location>
            <location evidence="7">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="KB204120">
        <property type="protein sequence ID" value="KJB84172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLM9"/>
    <dbReference type="STRING" id="29730.A0A0D2SLM9"/>
    <dbReference type="Gramene" id="KJB84172">
        <property type="protein sequence ID" value="KJB84172"/>
        <property type="gene ID" value="B456_N008100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784726"/>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPASYCG"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB84172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="558" mass="59504" checksum="3325FEF65E99C499" modified="2015-04-29" version="1">MKNTSWVLSFPCFETMLSTLQPPRYLSRLPLRGRTKSRPFHILSSAQPVTKTSFAADQSQILSIRDSLLNRHLSAVELTHSYLDRLKQTEPHINCFLHVSDPDKVLKQAQDIDDKIKRNEEVGPLAGVLVAIKDNICTADMPSTGGSYILEGYRPPFDATAVKRLKDLGAIVVGKTNLDEFGMGSTTEASAFKVTANPWDLSRVPGGSSGGSAASVSARQCVVSLGSDTGGSVRQPASFCGVVGLKPTYGRVSRFGLMAYASSLDVIGCFGSSVADTGILLHAISGHDSLDATSSKREVPDFTSQFTSASSLKSRPLEGLRVGLIRETVDAGVDSGVKSAIEGAATHLEQLGCVLKEVSLPSFSLGLPAYYILASSESSSNLSRYDGVRYGNQASSDELNALYEESRAKGFGSEVKMRILMGTYALSAGYYDAYYKRAQQVRTIIRKSFKAALDENDILISPAAPSAAYKIGEKKNDPLAMYAGDIMTVNVNLAGLPALVLPCGFVEGGAVGLPVGLQIIGAAFDEEKLVKVGHIFEQTLEGYNFVPPLITDVGGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SR84</accession>
    <name>A0A0D2SR84_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine dioxygenase</fullName>
            <ecNumber evidence="3">1.13.11.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G256700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteine + O2 = 3-sulfino-L-alanine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20441"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:61085"/>
            <dbReference type="EC" id="1.13.11.20"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:20442"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.20" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SR84"/>
    <dbReference type="STRING" id="29730.A0A0D2SR84"/>
    <dbReference type="Gramene" id="KJB44511">
        <property type="protein sequence ID" value="KJB44511"/>
        <property type="gene ID" value="B456_007G256700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4281">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KPRELEM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017172">
        <property type="term" value="F:cysteine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070483">
        <property type="term" value="P:detection of hypoxia"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20289">
        <property type="entry name" value="cupin_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012864">
        <property type="entry name" value="PCO/ADO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966">
        <property type="entry name" value="2-AMINOETHANETHIOL DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22966:SF63">
        <property type="entry name" value="CYSTEINE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07847">
        <property type="entry name" value="PCO_ADO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB44511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="320" mass="36323" checksum="B4EEBE8ACDD102D7" modified="2015-04-29" version="1">MTVETGGLVGQSKNNITTTVKHVNNRVRYGNKTEKKNRSYKKMRREVVFPRVPDVLQQLFVSCTQIFRGPGFVPPASDVNKLCDIIDKMKPEDVGLSKNLQFFKPTGSVNRTPRVTYTTIYQCDQFSLCIFFLPETAVIPLHNHPEMTVFSKLLLGKMHIKSYDWVEPKDSIPPSKCEISIFFKSPNRILSFVFDVIIIGFFFPLVVAVRLARLKANSVYTAPCNTSVLYPTTGGNIHQFTAVTPCAVLDVLGPPYSKEDDRDCSYYKDFPYSAFSNEGETTRVSEEEREGLGWLEEIEAPENAVMDRIDYLGPQIIENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRD1</accession>
    <name>A0A0D2SRD1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G379500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRD1"/>
    <dbReference type="STRING" id="29730.A0A0D2SRD1"/>
    <dbReference type="Gramene" id="KJB46634">
        <property type="protein sequence ID" value="KJB46634"/>
        <property type="gene ID" value="B456_007G379500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47531">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47531:SF2">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB46634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="390" mass="42802" checksum="82E89DA1CF2C82DB" modified="2015-04-29" version="1">MGSCGSKGSCRGGASSLSGGRKGISIGKNRVFQSSCLGAISGSADSHFDRQVVVVDHHNKDYGSNFTNQNSRERESVSDQVKRECSRKVEAESASDYEMPLPCISSNGVDIDASRSGSSSGRATTALRRANSLGSSRAYPVSPPSLTILNRDDNFETLEHRQLSPNSSSINLYSPLTFNDSDTYRERDRRVGVGSRESVERNRVLRRPSLSNFTLCPLQQSSHVGSQTHAFRGDRDTRQFATSPSKSTSVSGSAHTTTVLSHTPVFNIQGHEHRSNFLERRRRIRSQVSDLLAPVSQLHNLEKPGIMIYSSTTARASLYRIVKLAEALFELISMHFNYVLDEIHQQSVVLSSRASVSSIGSVPAPNEVVELLPVKIYNKSHKLHNDEAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSL6</accession>
    <name>A0A0D2SSL6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G007200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSL6"/>
    <dbReference type="STRING" id="29730.A0A0D2SSL6"/>
    <dbReference type="Gramene" id="KJB47034">
        <property type="protein sequence ID" value="KJB47034"/>
        <property type="gene ID" value="B456_008G007200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762637"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HFHCLME"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010331">
        <property type="term" value="F:gibberellin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048444">
        <property type="term" value="P:floral organ morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048530">
        <property type="term" value="P:fruit morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009740">
        <property type="term" value="P:gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009939">
        <property type="term" value="P:positive regulation of gibberellic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010325">
        <property type="term" value="P:raffinose family oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000087">
        <property type="entry name" value="Gibberellin receptor GID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF98">
        <property type="entry name" value="GIBBERELLIN RECEPTOR GID1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0939">Gibberellin signaling pathway</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0675">Receptor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="8">
        <location>
            <begin position="108"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB47034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="344" mass="38915" checksum="FCD3145F29772369" modified="2015-04-29" version="1">MAGSNEVNLNESKRVVPLNTWVLISNFKLAYNLQRRPDGTFNRDLSEFLDRRVPANINPVDGVFSFDHVDGATGLLNRVYQPSSLNEAQWGMVDLEKPLSTTEIIPVIVFFHGGSFTHSSANSAIYDTFCRRLVSLCKAVVVSVNYRRSPEHRYPCAYDDGWAALKWVKSRTWLQSGKDSNVHVYLAGDSSGGNIAHHVAVRAAEADVEVLGNILLHPMFGGQKRTESEKRLDGKYFVTLHDRDWYWRAYLPEGEDRDHPACNPFGPRGRSLEGLKFPKSLVVVAGLDLIQDWQLAYVEGLKKSGQEVKLLFLEKATIGFYFLPNNNHFYCLMEEIKNFVNPNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCJ4</accession>
    <name>A0A0D2TCJ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G030500</name>
        <name evidence="5" type="ORF">Gorai_010980</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCJ4"/>
    <dbReference type="STRING" id="29730.A0A0D2TCJ4"/>
    <dbReference type="Gramene" id="KJB54344">
        <property type="protein sequence ID" value="KJB54344"/>
        <property type="gene ID" value="B456_009G030500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766030"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PYYGTFV"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016847">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000038">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="49"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB54344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0594058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="438" mass="49215" checksum="7BA47C1BCB5FBF89" modified="2015-04-29" version="1">MAIEIEQPRVGLSKVAVSKTHGEDSPYFAGWKAYDENPYHETSNQSGVIQMGLAENQVSFDLLEKYLEEHSEASSWGKGAPGFRENALFQDYHGLKSFRQAMASFMEQIRGGRAKFDPDRIVLTAGATAANELLTFILADPGDALLIPTPYYPGFDRDLRWRTGVNIVPIHCDSSNNFQITPEAMEAAYQSAESMNLKVRGILITNPSNPLGATIQRSALEQILDFAVNKNIHLVSDEIYSGSTFSSSEFISIAEILETRGYKDAERVHIVYSLSKDLGLPGFRVGTIYSYNDQVVTTARRMSSFTLISSQTQHLLACMLSNKEFSENYIKTNRERLSKRYDMIIKGLKKAGIECLKGNAGLFCWMNLSPLLEKPTRESELALWKVILNEVKLNISPGSSCHCSEPGWFRVCFANMSEQTLEIALERIHKFMEQRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TEQ8</accession>
    <name>A0A0D2TEQ8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G2819002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TEQ8"/>
    <dbReference type="Gramene" id="KJB74238">
        <property type="protein sequence ID" value="KJB74238"/>
        <property type="gene ID" value="B456_011G2819002"/>
    </dbReference>
    <dbReference type="OMA" id="YEDERIF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000002">
        <property type="entry name" value="Disease resistance protein (TIR-NBS-LRR class)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058192">
        <property type="entry name" value="WHD_ROQ1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF479">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23282">
        <property type="entry name" value="WHD_ROQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein Roq1-like winged-helix" evidence="4">
        <location>
            <begin position="249"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB74238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="54986" checksum="194304AA014CE567" modified="2015-04-29" version="1" fragment="single">MNNKSSTAFEELVGIDYQKKTILKLINQNDCRVIGLWGMAGIGKTTLANVVYHEICSKFKSCWFLQNVGEKIRKQGMESLRNNFLSKILDQEIDVLTPSIGSAFIRERLNNKKVIVVVDDVDDPDLIDYLGVKHFGDGSKIILISRDRQVLKNGGAEKIHKVNELNEKSSLQLFSTFAFKQLNPTANFRDLSNQFVRYAQGNPLALKVLGSKLYTKSRKEWESEVDRLKEYGQPKISQILKSSFDELDELEKNLFLDIACFFKGKYKKEVEDILCSLYNGAVCGISNLVDKCLLDTIHFQDMLEEDLRLQDLRRSRSASTCQSAFAGRPLIISMHDILEEMGKDIIRQEATGIGNCSRLWSPNNVHQMLRYNKGNEAIKGIKLDMSQIDNLKLSPTVFENMLNLRFIHFYLPRKFGECWNKKLLADQVDIVSLPDELRYLCWEYYPFKSLSSSFNPKNLVVLKLPHGDMEQLWNGDNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGD8</accession>
    <name>A0A0D2TGD8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_012G009800</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for pathogen-associated molecular pattern (PAMP, e.g. chitin and flg22)-triggered immunity (PTI) involving reactive oxygen species (ROS) accumulation and triggering plant defense, including defense-related gene expression (e.g. PR1 and LOX). Ensures specific recognition of the EPD1 effector of Verticillium dahliae, resulting in a hypersensitive response known as effector-triggered immunity (ETI), characterized by the activation of programmed cell death to limit infection by the pathogen. Priming plants with the incompatible pathogen V.dahliae leads to an increased resistance to compatible pathogens, as a result of systemic acquired resistance (SAR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGD8"/>
    <dbReference type="STRING" id="29730.A0A0D2TGD8"/>
    <dbReference type="Gramene" id="KJB74833">
        <property type="protein sequence ID" value="KJB74833"/>
        <property type="gene ID" value="B456_012G009800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780538"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMDGQYG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000258">
        <property type="entry name" value="Probable serine/threonine-protein kinase PBL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000615">
        <property type="entry name" value="TyrPK_CSF1-R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0928">Hypersensitive response elicitation</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="47"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="327"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000615-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB74833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="394" mass="44240" checksum="0C2DE569EC94581D" modified="2015-04-29" version="1">MQDSPETKIPCILPLAAKDVKDLLQNPGYSNVDIFTYEEMRLATNQFRPDYILGEGGFGAVYKGVIDETVRPGYTSTAVAIKELNPDGFQGDREWLTEVNYLGQLSHSNLVKLIGYCCEDEHRLLVYEYMASGSLEKHLFRRVGCSLTWSKRMKIALDAAKGLAFLHGAERPIIYRDFKTSNILLDADFNAKLADFGLAKDGPTGDQTHVSTRVMGTYGYAAPEYVMTGHLTARSDVYGYGVVLLEMLLGRRAMDKCRPSREHNLVEWARPLLNHNKKVLRILDPKMDGQYSAKTARKVANLAYQCLSQNPKGRPLMNEVVELLETLETNDDSQEEACTSVKKRNSGRTGSHREGSADRSRSTNVRSRSEPPKECELYDPTSFETEEKSESDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQ49</accession>
    <name>A0A0D2TQ49_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G313900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQ49"/>
    <dbReference type="SMR" id="A0A0D2TQ49"/>
    <dbReference type="STRING" id="29730.A0A0D2TQ49"/>
    <dbReference type="Gramene" id="KJB45585">
        <property type="protein sequence ID" value="KJB45585"/>
        <property type="gene ID" value="B456_007G313900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYEHIDA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000025">
        <property type="entry name" value="TBC1 domain family member 15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF597">
        <property type="entry name" value="RAB-GAP TBC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="63"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB45585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="432" mass="49786" checksum="355F01C1DACEFB0F" modified="2015-04-29" version="1">MWGAPAEPADSYYEVRPECTDVPVTKFKIKPGKTLSVRKWQTSFAPDGQLDIGKTLNRIHRGGIHPTIRGEVWEFLLGCFDPKSTYEEREQLRQQRREQYQKWKNDCREIFPVVGSGQFITAPVITEDGQPIQDPLVLLEANNAVGDGPNSTEIVQELINRGPLDKKIIDWLLLLHQIGLDVKRTDRSLVFYEKQENLSKLWDILAVYAWIDTDVGYCQGMSDLCSPMIILLDDEADSFWCFERLMRRLRGNFRCTESSVGVETQLSHLAAVTQVIDPKLHQHLETLGGGDYLFAVRMLMVLFRREFSFCDSLYLWEMMWALEYDPDLFYLYEEPTPSLEESKKKAKSMRHYGKFERENMKIKTDEAPLPISVFLVASVLKEKSTKLLHEARGLDDVVKILNDITGSLDAKKACNEAIKLHKKYLKKQQAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TUA6</accession>
    <name>A0A0D2TUA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_013G029000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TUA6"/>
    <dbReference type="STRING" id="29730.A0A0D2TUA6"/>
    <dbReference type="Gramene" id="KJB79013">
        <property type="protein sequence ID" value="KJB79013"/>
        <property type="gene ID" value="B456_013G029000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783092"/>
    <dbReference type="eggNOG" id="KOG0988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTILDHE"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057590">
        <property type="entry name" value="PH_RDR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058751">
        <property type="entry name" value="RDRP_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058763">
        <property type="entry name" value="RRM_RDR1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF1">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24823">
        <property type="entry name" value="PH_RDR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26252">
        <property type="entry name" value="RdRP_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26250">
        <property type="entry name" value="RRM_RdRP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDR1/2-like RRM" evidence="11">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RDR1/2-like PH-like" evidence="10">
        <location>
            <begin position="102"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP helical" evidence="12">
        <location>
            <begin position="269"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP core" evidence="9">
        <location>
            <begin position="371"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="domain" description="RDRP C-terminal head" evidence="13">
        <location>
            <begin position="948"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF26252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF26253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB79013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1110" mass="128110" checksum="8D5284DF80E263E9" modified="2015-04-29" version="1">MGKTIQVYGFLSNVSAGEVKTFLEGYTGRETVYALKIRQHKKGGRAYAIVQFTRSSAAELIIRLANQRLYYGRSYLKAREMETDIVPKPRAFLHTMERVTVNFGCQVSVEKFYVLWKAENVTLNFGTGMRKLEFLVSYCRSKYKLELFYENIWQIELRCPDSQTSKHLLIQLFGAPRIYEKEVRASELVFDDPLLNYFKDVPDDQWVRTTDFTRSNCIGQSSVLCLELPHNLRLPNFRENFAYYKENESRLVLESGSSYSCNLSLVPIVCPLRVIDLPFEILFKVNLLVQNGCIPGPALDDTFYRLVDPCRMDKVYIDHALEKLYYLRECCYEPSRWLFEEYKNFSRSRKYQGSPAISLDEGLVYVRRVQITPSRVYFCGPEINVSNRVLRQFHNDIDNFLRISFVDEELEKIHSINVQARGRRTSIYERILSTLRNGVLIGDKRFEFLAFSSSQLRENSAWMFASRKGLTAADIRSWMGNFSKIRNVAKYAARLGQSFSSSTETLSVSKDEINLIPDIEIMKDGIKYVFSDGIGKISAKFAKKVAAKCRLKGCTPSAFQIRIGGFKGVVAIDPTSSWKLSLRKSMEKYESENTKLDVLAWSKYQPCFLNRQLITLLSTLGVPDRAFEKKQREVIEQLNALLTDPLEAQEALELMSPGENTNILKEMLLCGYKPDAEPFLSMMLEAFRASKLLELRTKARIFVQKGRSMMGCLDETRTLNYGQVFVQFSGSRSEQRCIVQGKVIVAKNPCLHPGDVRVLRAVNVPDLHHMVDCVVFPQKGTRPHPNECSGSDLDGDIYFVCWDPELIPYKQMDPMDYSPAPTTILDHEVTIEEIEEYFTNYIVNDSLGIISNAHTAFADREPGKAMCHPCLELAKLFSIAVDFPKTGVPAEIPQELRVKEYPDFMEKPDKPSYQSHNVIGKLFREVKNLAPNECSIKFLTREKMQRFYDPDMEVEGFEDYIDDAFFHKSKYDYKLGNLMDYYGVKTEAEILSGGILKMSRSFTKKRDAEAISMAVRSLRKEARSWFNEERSELDEEIDDAYAKASAWYYVTYHPSYWGQYNEGMNRDHFLSFPWCVYDKLIQIKKEKAAVREALDLSSLEHRFQRRLHLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TUM8</accession>
    <name>A0A0D2TUM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G040800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TUM8"/>
    <dbReference type="Gramene" id="KJB79268">
        <property type="protein sequence ID" value="KJB79268"/>
        <property type="gene ID" value="B456_013G040800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052929">
        <property type="entry name" value="RNase_H-like_EbsB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074">
        <property type="entry name" value="BNAC02G40300D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074:SF61">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8827" checksum="6955B00F70165A35" modified="2015-04-29" version="1" fragment="single">VPLVYWQLPQKHSVKINFDAGFCQQNNKSCSGIILRDDSGIVLWSKAIMHVNIPSPFAAEAMVCVEGARWAYSWVFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U386</accession>
    <name>A0A0D2U386_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phenylalanine ammonia-lyase</fullName>
            <ecNumber evidence="6 13">4.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_009G416300</name>
        <name evidence="15" type="ORF">Gorai_013615</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-phenylalanine = (E)-cinnamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21384"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="EC" id="4.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Phenylpropanoid metabolism; trans-cinnamate biosynthesis; trans-cinnamate from L-phenylalanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.24" evidence="6 13"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U386"/>
    <dbReference type="STRING" id="29730.A0A0D2U386"/>
    <dbReference type="Gramene" id="KJB62426">
        <property type="protein sequence ID" value="KJB62426"/>
        <property type="gene ID" value="B456_009G416300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768043"/>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNFHGDY"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="UniPathway" id="UPA00713">
        <property type="reaction ID" value="UER00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045548">
        <property type="term" value="F:phenylalanine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009800">
        <property type="term" value="P:cinnamic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.20:FF:000001">
        <property type="entry name" value="Phenylalanine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000009">
        <property type="entry name" value="Phenylalanine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000009">
        <property type="entry name" value="Phenylalanine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="8 13" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB62426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0596808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="721" mass="78341" checksum="1B68E13131EACEF6" modified="2015-04-29" version="1">MDMITQNAQQSSSLESFCTTTTTAKGGVVDPLNWGVAAKSLQGSHLDEVKRMVAEYRRSLVKLGGETLTISQVAAIATRDLGVKVELSEDARAGVKASADWVLDGMNKGTDSYGVTTGFGATSHRRTKQGAALQKELIRFLNAGIFGNGIESCHTLPHSATRAAMLVRINTLLQGYSGIRFEILEAITKLLNHNVTPCLPLRGTITASGDLVPLSYIAGLLTGRPNSKAVGPNGEPLDAQEAFHVAGIDSGFFVLQPKEGLALVNGTAVGSGLASMVLFEANILAVLSEILSAIFAEVMNGKPEFTDHLTHKLKHHPGQIEAAAIMEHILEGSSYVKAAKKLHEMDPLQKPKQDRYALRTSPQWLGPQIEVIRFATKSIEREINSVNDNPLIDVSRNKALHGGNFQGTPIGVSMDNARLAIAAIGKLMFAQFSELVNDFYNNGLPSNLSGGRNPSLDYGFKGAEIAMASYCSELQYLANPVTNHVQSAEQHNQDVNSLGLISSRKTAEAVDILKLMSSTFLVALCQAIDLRHVEENLRNTVKNTVSQIAKKTLTTGANGELHPSRFCEKDLLKAVDREYVFAYIDDPCSATYPLMQKLRQVLVEHALTNGESEKNTSTSIFQKITDFEEELQAVLPKEVESARVTLENGNAAIPNMIKDCRSYPLYKFVREELGTGLLTGEKVKSPGEEFDKVFTAMCQGKIIDPMLECLKEWNGAPLPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4A1</accession>
    <name>A0A0D2U4A1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G437200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4A1"/>
    <dbReference type="STRING" id="29730.A0A0D2U4A1"/>
    <dbReference type="Gramene" id="KJB62806">
        <property type="protein sequence ID" value="KJB62806"/>
        <property type="gene ID" value="B456_009G437200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768419"/>
    <dbReference type="eggNOG" id="ENOG502QSMM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPAMAFP"/>
    <dbReference type="OrthoDB" id="943487at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF683">
        <property type="entry name" value="OS05G0506800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB62806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44266" checksum="85FFB6759E4D1C20" modified="2015-04-29" version="1">MATSSSCSSLKQHFLVFLIVIISSIINSPVNGCFTSIFSFGDSLTDTGNLLELSISESTKPPHSAFLPYGCTFFHRPTGRFCDGRLVIDFLAEALGFSFLPPFYGSKSGKWEKFRQGANFAVAGATALNSSFLAEQGIHSVSTNISLGVEVNSFKHLLPSLCSSSSNCKKLLRKSLIVMGEVGGNDYNHAFKQGKNIENIRRLVPLVVDIISLSIKELIELGAVTFLVPGNFPIGCSPSLLTSFHGSEKDQYDPLTGCLTWLNQFSQHHNELLRKELENIRNLHPQINIIYVDYYKASTPFYQSPKNYGFKETLKACCGIGGLYNYDPLIYCGYPPLKQCCNDPSSYISWDGIHFTEVVNKWLAHTVFEELMNTIPRLGSLCPLSTVNKLRILYPMFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5X5</accession>
    <name>A0A0D2U5X5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G234600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5X5"/>
    <dbReference type="Gramene" id="KJB83193">
        <property type="protein sequence ID" value="KJB83193"/>
        <property type="gene ID" value="B456_013G234600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRWSHFL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35300">
        <property type="entry name" value="COACTIVATOR CBP, KIX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35300:SF4">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB83193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="271" mass="30104" checksum="D031BD92370ADEAD" modified="2015-04-29" version="1">MMPSTRLSVEMRVLKQESFCHLVLKLNLGCYPVRYSRSQQHCNPRTYLTPRAPEHVSLAPRIFDEGSEESCPWLPPVQSVRIATDVNSNISVSQAYHRWSHFLSEDCPYDCDQSTRIETKTSPIGQVYPLYHGIHHQNTQPLTGSPVCENIMSDTIFVRSPIGTSLAELGVNGSSLNLFSSSDIGGKGDGLQDMKRTNEKSFLAECDLSLRLGLFSDPRVQVEKDSIVETGDVGQSSPCDGGKVNEVFQQKSKEFCFSLEGTVNGHFEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9R9</accession>
    <name>A0A0D2U9R9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G102600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9R9"/>
    <dbReference type="STRING" id="29730.A0A0D2U9R9"/>
    <dbReference type="Gramene" id="KJB65594">
        <property type="protein sequence ID" value="KJB65594"/>
        <property type="gene ID" value="B456_010G102600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQPFFSQ"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF63">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="72"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="253"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB65594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="548" mass="59874" checksum="B5B97303FCF339A6" modified="2015-04-29" version="1">MQACNGAAMMGSLQQPIWVKGNRPIFPLKGYGLKLNSVKPCRAQLESSLVTGKPPSSDSFPVAETRFVDHGLSEADPEVRAIINKEKERQFKSLELIASENFTSRAVMEAVGSCLTNKYSEGLPGKRYYGGNEYIDELEILCQKRALAAFHLDENKWGVNVQPLSGSPANFEVYTAILNPHDRIMGLDLPHGGHLSHGFMTPKRRVSGTSIYFESMPYRLDESTGNSSLLLRLNWFSGWYAYLVVDLICLKFGTGLVDYDMLEKTATLFRPKLIICGASAYPRDFDYPRMRKIADAVGAFLMMDMAHISGLVAASVVADPFEYCDIVTTTTHKSLRGPRGGMIFFKKDPVLGVDLESAINNAVFPGLQGGPHNHTIGGLAVCLQHAQSPEFKAYQNQVVSNCRALARRLVELGYTLVSGGSDNHLVLVDLRPLGIDGARVEKILDMASITLNKNSVPGDKSALVPGGIRIGSPAMTTRGFTEKEFTAIAEFIHEGVQITIEAKGLASGSKVQEFLKFVSSPDFPLTDKVSNLCSRVEALTTQFPIPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UD34</accession>
    <name>A0A0D2UD34_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G155500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UD34"/>
    <dbReference type="STRING" id="29730.A0A0D2UD34"/>
    <dbReference type="Gramene" id="KJB66744">
        <property type="protein sequence ID" value="KJB66744"/>
        <property type="gene ID" value="B456_010G155500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773037"/>
    <dbReference type="eggNOG" id="KOG0311">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CISSHGY"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16531">
        <property type="entry name" value="RING-HC_RING1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044592">
        <property type="entry name" value="RING1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46537:SF3">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46537">
        <property type="entry name" value="OS11G0578200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="192"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB66744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="487" mass="54531" checksum="01ED30C11F0F6EE6" modified="2015-04-29" version="1">MPAQKPSSEAVFTPEGSDLLLLDQSINNHEQHPVETEDAADESDRCPCPCNENEQDYVIVKLSDVRKEVQCPICLGIIRKTRTVMECLHRFCRECIDKSMRMGNNECPACRTHCASRRSLRDDPNYDSLIAALYPDIEKHEEEELTLHEEEKARNKQIQASITQTLHRQLEVLGRKRTVKANASATIRRSNCRYQRRKYRASEPQESDNNEDANENGSTGSSLADEDLTEVKPKRLKRWEGRCSQPSSAASADGVGDENDSEVNRESLGVSAALSPSERLHLGASGIRSHTAHGSLSGDENDSEVNRESLGLFAALNGLSERLHWGAGGMRSNTRHGSLSGGNGKKARNSRLPKLVDCLQNLEEKDDELDIHLMLVSIDEQRIPCLQRPYLCCRPTLLVRHLCQYVALQTALQASEIEIYLVKELYSTANMSTYKITKPGLVESVRDKLEVLKEEETLGGLGRQTSSHSHLILAYQKKENRNGQCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMJ6</accession>
    <name>A0A0D2UMJ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fe(2+) transport protein 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G049900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMJ6"/>
    <dbReference type="STRING" id="29730.A0A0D2UMJ6"/>
    <dbReference type="Gramene" id="KJB69914">
        <property type="protein sequence ID" value="KJB69914"/>
        <property type="gene ID" value="B456_011G049900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777311"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHWTKAS"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF48">
        <property type="entry name" value="ZINC TRANSPORTER 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252937" description="Fe(2+) transport protein 1-like" evidence="9">
        <location>
            <begin position="28"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB69914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38219" checksum="F6AFE6724ED1CD4A" modified="2015-04-29" version="1">MSMASLYVRLFSIFLLIICIFPPQALSVVPEECQTKTDGCTNKEKALPLKVIAIFSILIASVIGVCSPLFTRSIPALNPDRNLFVIVKCFAAGIILATGFMHVLPDSFNMLSSRCLKENPWHEFPFTGFVAMLSAIITLMVDSMATSIYTKKCNNGVIPEVASPAGGGQQEMVVVNVGQFHGHHHGLKPAPGTVDQQLLRYRVVAMVLELGIVVHSVVIGLSLGASNNTCSIKGLVAALCFHQMFEGMGLGGCILQAEYKTMKKFIMVFFFSVTTPFGIALGIALANTYKENSPTALITVGLLNASSAGLLIYMALVDLLAADFMGSKLQASVKLQIKSYVAVLLGAGGMSVMAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMR6</accession>
    <name>A0A0D2UMR6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="13">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G016500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Extracellular space</location>
            <location evidence="13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="13"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMR6"/>
    <dbReference type="STRING" id="29730.A0A0D2UMR6"/>
    <dbReference type="Gramene" id="KJB69326">
        <property type="protein sequence ID" value="KJB69326"/>
        <property type="gene ID" value="B456_011G016500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776394"/>
    <dbReference type="eggNOG" id="ENOG502QRCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWHLTKD"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="1 13" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112942" description="Xyloglucan endotransglucosylase/hydrolase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="14">
        <location>
            <begin position="25"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB69326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="300" mass="34878" checksum="7137BB1B8220B19D" modified="2015-04-29" version="1">MKKRVSPMASLFFISALAAAFHSSSEAAASSQSPFEDNFSIMWSENHFKTSEDGNTWFLSLDKETGCGFQTKQRYRFGWFSMKLKLVGGDSAGVVTAYYMCSENGAGPERDELDFEFLGNRTGQPYLIQTNVYKNGVGGREMRHMLWFDPTEEFHSYSILWNDHQIVFFVDRVPIRVFKNNGEKNYFFPNEKPMYLFSSIWNADDWATRGGLEKTDWKKAPFVSSYKDFSVDGCQWEDPYPACVSATTKKWWDQYQAWHLTDSQKMDFAWVQRNLVIYDYCKDTDRYPKLPVECSLSPWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNC3</accession>
    <name>A0A0D2UNC3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G032400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UNC3"/>
    <dbReference type="STRING" id="29730.A0A0D2UNC3"/>
    <dbReference type="Gramene" id="KJB69591">
        <property type="protein sequence ID" value="KJB69591"/>
        <property type="gene ID" value="B456_011G032400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777898"/>
    <dbReference type="eggNOG" id="KOG0922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHEVMET"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17980">
        <property type="entry name" value="DEXHc_DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000767">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001326">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF136">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX35-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="58"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="254"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB69591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="697" mass="77948" checksum="4FC3C9F39A22F482" modified="2015-04-29" version="1">MAQFWKPGTEKPRLVEDEDGGVIFLSSSYSSSSSGYGYVSIEKQRQRLPVYKYRTAILYLVESHATTIVVGETGSGKTTQIPQFLKEAGWADGGRVIACTQPRRLAVQAVASRVAEEMGVKLGEEVGYTIRFEDISNPDLTRIKFLTDGVLLREMMDDPLLTKYSVIMVDEAHERSISTDIVLGLLKKIQKRRPELRLIISSATIEAKSMSNFFLSSKRRQALECEELRPRLEPAILSVEGRGFNVQIHYVEDPVRDYIQAAVSTVLLINDKEPPGDILVFLTGQDDIDAAIKLLTEEARSNGKNSSGLIILPLYSGLTRAEQDLIFSPTPKGKRKVVISTNIAETSLTLEGIVYVVDSGFSKQRFYNPISDIENLVVAPISKASARQRAGRAGRLRPGMCYRLYTEEYFLNEMSVQGIPEIQRSNLVSCVIQLKALGIDNILGFNWPASPSPESMIRALEVLFSLGVLDDDAKLTSPVGFQVAEIPLEPMIAKMILSSNELGCSDEIITIAAVLSIQSIWFSARGAQKELDEAKLRFAAAEGDHVTFLNIYKGFLQSGRSSKWCHKNFINYHAMKKVMEIREQLKRIALRLGIVLKSCETDMQLVRKAVTAGFFANACRLEAYSHGGMYKTIRGSQEVYIHPSSVLFRVNPKCVIYHSLVSTDRQYMRNVISIDPSWLTEVAPHFYQQQRHNPTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPP6</accession>
    <name>A0A0D2UPP6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Subtilisin-like protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_011G061400</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPP6"/>
    <dbReference type="MEROPS" id="S08.A28"/>
    <dbReference type="Gramene" id="KJB70156">
        <property type="protein sequence ID" value="KJB70156"/>
        <property type="gene ID" value="B456_011G061400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QZDA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWLLHSA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.2310:FF:000001">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000006">
        <property type="entry name" value="Subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000005">
        <property type="entry name" value="subtilisin-like protease SBT1.5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000003">
        <property type="entry name" value="Subtilisin-like protease SBT1.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252989" description="Subtilisin-like protease" evidence="12">
        <location>
            <begin position="20"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="15">
        <location>
            <begin position="28"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="13">
        <location>
            <begin position="123"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="14">
        <location>
            <begin position="365"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="16">
        <location>
            <begin position="652"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="10 11">
        <location>
            <position position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB70156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="764" mass="80962" checksum="67D2BF99D3B573A6" modified="2015-04-29" version="1">MAISFIFFLSLLLIPFSSSSSSDCPQNFIIHVSKSHKPSLFSSHHHWYSSILHSLPPSPHPIKLLYTYQLSINGFSARLTSSQANKLKHFPGILSARQIHTTRTPHFLGLSDGVGLWQNSHYGDGIIIGVLDTGIWPERPSFLDSGLPPVPNTWKGTCETGPDFPASACNRKIIGARAFYKGYESYLEGPIDEMKESKSPRDTEGHGTHTASTAAGSMVSNASLFEFAYGEARGMATNARIAAYKICWKMGCFDSDILAAMDQAIADGVDVISLSVGATGYAPQYDHDSIAIGAFGAANHGIVVSCSAGNSGPGPSTAVNIAPWILTVGASTIDREFPADVVLGDGRIFGGVSLYSGEPLGDSKLPLVYGGDCGDRYCHMGSLNSSKVGGKIVVCDRGGNARVEKGGAVKLAGGLGMILENTADNGEELISDAHLIPATMVGEAAGNKILEYIKTTQFPTATISFRGTVIGPSPPAPKVAAFSSRGPNHLTPEILKPDVIAPGVNILAGWTGAAAPTDLDIDPRRVDFNIISGTSMSCPHVSGLAALLKKAYPNWSPAAIKSALMTTAYNLDNSGHTINDLATGEEASPFIYGAGHVDPNRALNPGLVYDTDSSDYIAFLCSIGYDSKRIEVFVREPNSSDVCATKLATPGDLNYPSFSVVFNSNDHVVKYRRKVKNVGTSAGAVYEAKVNAPPGVKISVSPSKLEFSAVNQTLSYEVSFASDSLGLSSVESQGFGSIEWSDGVHLVRSPIAVRWIQGVQEESF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USY4</accession>
    <name>A0A0D2USY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_011G121900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USY4"/>
    <dbReference type="SMR" id="A0A0D2USY4"/>
    <dbReference type="STRING" id="29730.A0A0D2USY4"/>
    <dbReference type="Gramene" id="KJB71410">
        <property type="protein sequence ID" value="KJB71410"/>
        <property type="gene ID" value="B456_011G121900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB71411">
        <property type="protein sequence ID" value="KJB71411"/>
        <property type="gene ID" value="B456_011G121900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIENGHY"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006970">
        <property type="term" value="P:response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14662">
        <property type="entry name" value="STKc_SnRK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000132">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000045">
        <property type="entry name" value="Serine/threonine-protein kinase SRK2E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF490">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SRK2G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="4"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB71411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="353" mass="40537" checksum="4AD046C2DC860BA7" modified="2015-04-29" version="1">MEKYEVVKDLGAGNFGVARLLRHKDTKELVAMKYIERGHKIDENVAREIINHRSLRHPNIIRFKEVVLTPTHLAIVMEYAAGGELFDRICSAGRFSEDEARYFFQQLISGVNYCHSMQICHRDLKLENTLLDGSPAPRLKICDFGYSKSSLLHSRPKSTVGTPAYIAPEVLARREYDGKLADVWSCGVTLYVMLVGAYPFEDQADPRNFRKTIQRIMAVQYKIPDYVHISQDCKNLLSRIFVANPSRRITLKEIKNHPWFLKNLPRELTDTAQAAYYRSDNPTFSLQSIDEIMKIVEEARIPPPASVPVKGFGWGQDDDEEEDIDGEVKEDDEEDEYDKRVKEVHASGEYQIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UU16</accession>
    <name>A0A0D2UU16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Beta-glucuronosyltransferase GlcAT14A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G162900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UU16"/>
    <dbReference type="Gramene" id="KJB72164">
        <property type="protein sequence ID" value="KJB72164"/>
        <property type="gene ID" value="B456_011G162900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIGWRES"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044610">
        <property type="entry name" value="GLCAT14A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45719:SF10">
        <property type="entry name" value="CORE-2_I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45719">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="51902" checksum="CCF41B23180A135A" modified="2015-04-29" version="1">MYHHPKSPPFTPSTTAATTLSKDNSKCTPYIILASFFFSLLFILFLLSTSASQSLLTIRRDPSLFPNRPVSLTKIPYGPTPPSIAYLISGSAGDSARILRLLLATYHPRNHYLLHLDLSAPQTERDRLAVTIHSVPIFRAAQNVDVIGKANYAYQRGSSTVTSALHGASILLRLSSKWDWFISLSAGDYPLVTQDDLLHILSYLPKNLNFVNHSSYIGWKESKSLKPIIVDTGHYLLERDEIFYVTQKRVLPNSFRLFSAGVVIQGNYMQFLLLRSFSACFAKLEIPSFAGSAFAMLTRSFIEFCILGTDNFPRTLLMYLANMPYSFTNYFPTILCNSKFKSTVINHNLQYVAFNMSSSKKKLSSRDLAEFNAMIQTGDAFATQFKFDDPVLDRIDRKILKRKPGRVVQGGWCLGIPANDTCSVWGDADILRPGKGAKRLERRIVKLLSGDRFRSQQCLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UV10</accession>
    <name>A0A0D2UV10_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Inositol-tetrakisphosphate 1-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_009G277900</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13253"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57895"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.159"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13254"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1D-myo-inositol 1,3,4-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20940"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.159"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:20941"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>1D-myo-inositol 3,4,5,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12452"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57539"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.134"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:12453"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="9">
            <dbReference type="Rhea" id="RHEA:12454"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:70287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:189099"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:70288"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ITPK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UV10"/>
    <dbReference type="STRING" id="29730.A0A0D2UV10"/>
    <dbReference type="Gramene" id="KJB59870">
        <property type="protein sequence ID" value="KJB59870"/>
        <property type="gene ID" value="B456_009G277900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQS1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VADMFMV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052726">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052725">
        <property type="term" value="F:inositol-1,3,4-trisphosphate 6-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047325">
        <property type="term" value="F:inositol-3,4,5,6-tetrakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052835">
        <property type="term" value="F:inositol-3,4,6-trisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032957">
        <property type="term" value="P:inositol trisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.220:FF:000002">
        <property type="entry name" value="Inositol-tetrakisphosphate 1-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008656">
        <property type="entry name" value="Inositol_tetrakis-P_1-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040464">
        <property type="entry name" value="InsP(3)kin_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041429">
        <property type="entry name" value="ITPK1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14217:SF39">
        <property type="entry name" value="INOSITOL-TETRAKISPHOSPHATE 1-KINASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05770">
        <property type="entry name" value="Ins134_P3_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17927">
        <property type="entry name" value="Ins134_P3_kin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038186">
        <property type="entry name" value="ITPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Inositol-tetrakisphosphate 1-kinase N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp" evidence="15">
        <location>
            <begin position="92"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 1,3,4-trisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00033645"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051312"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00051366"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00051721"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR038186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR038186-2"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF05770"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB59870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="32722" checksum="7F941DC3DB5B9995" modified="2015-04-29" version="1" fragment="single">KLKSFLRPKLQGLARNKGISFVPIDQSRPLSDQGPFDIVLHKMTGREWHQILEEYRQTHPKVLVLDPPDAIQHLHNRQSMLQCVADMNLFESYGKVGVPRQLVIKRDTSSIPDFVAEAGLRLPLVAKPFVNDGSEKSHELSLAYDQYSLQKLEPPLVLQEFVNHGGVLFKVFIVGEAIKVVRRFSLPDVTIRELSTYVGVYQFPRVSCAAACADDADLDSSVADMFMVGSNLSLLWGLRLFNLDIIREHGTRDHFYVLDINYFPGYGKMPRYEQIFTDFILNLMKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UVC5</accession>
    <name>A0A0D2UVC5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G194400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UVC5"/>
    <dbReference type="Gramene" id="KJB72749">
        <property type="protein sequence ID" value="KJB72749"/>
        <property type="gene ID" value="B456_011G194400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB72749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="95" mass="11191" checksum="ED7A84BFD6AB0737" modified="2015-04-29" version="1">MKNLQLEQIPPYYEILMKVVNFTASLNLQSFFTFGLGSNIWEENLSESILIFFFFRLLKFVNEFKSIEKFKIFNTNNLGQWNQGSSTGNCNWCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UWD1</accession>
    <name>A0A0D2UWD1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_011G218200</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UWD1"/>
    <dbReference type="STRING" id="29730.A0A0D2UWD1"/>
    <dbReference type="Gramene" id="KJB73154">
        <property type="protein sequence ID" value="KJB73154"/>
        <property type="gene ID" value="B456_011G218200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQYD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSNICKG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000479">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000299">
        <property type="entry name" value="Piriformospora indica-insensitive protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF72">
        <property type="entry name" value="REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="658"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="687"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB73154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="954" mass="104845" checksum="2F84DD66F61687BB" modified="2015-04-29" version="1">MEADTLLKWKASLDNTTQTLLSSLWVGSSHCNWVGITCDKDGSITNLSLTGYGLRLKGTLHNLNFHSFPNLIELNLHNNSLYGPIPSHIGYLSKLIFLDFLQLISLVSNKISGPIPQEIGNLSTVSNIFFYLNHLSGPIPASIGRLHKLHRLDLNRNRLNGSIPKEVGLLRSLLLLDFSGNRLTGLVPTSIGNLSNLVYLYLYDNYLSEIGSMTSLTTLTLSQNMFSGLIPKEVGMLKSLSELDLSNNTFSGQIPTSIGNLSNLVHLFLYDNNLSGVIPKEVGMLKSLSPIPPIYSNLTNLQLSNNHLTGPLPENLCLGGVLTRLAMISNNLSGPIPSSLRSCKSLNRVRLDGNHLTGNISEAFGIYPHLNYASLSDYNFYGELSPNWGQCHNLTSLRVSNNNISGKIPFELGHATHGNQFSGKIPSEIGLLSNVERLSLASNNLRGPIPDDLGNCSKLINLNLSKNNLGESIPSSIGYINALQSLDLSQNSLFGNIPQQFGKLQSLEILNLSRNMLNGSSPKAFNYLHGLRFVNISYNQLEGPIPDLKAFHEASFNALRNNKGLCGNATGLMPCVLPSRDNHGHTKSTKLIILFVLPLFGGLLILLFILVASFLTFCKKTPTKKSEPMEEQDGDIFTILGFNGRILHDSIIEATEDFSSDYCIGSGGYGSVYKAALPTGQVVAVKKLHQSEDSILINNLKDFESEIIALLELRHHNIVQMYGFCSHPQHSFLVYEFMERESLRMVLSNNEQAKELDWKKRLNVVKGLANALTYMHHDHSQPIVHRDISSNNVLLDLDYEARVSDFGTARILKPDSSNWTSLASTYGYIAPDKKSDVYCFGVLTIEVLMGRHPGDLLSYLSSSASASTLPFMSNDQHVLLKDVIDQRLSPPEIDAAEGVVSTIKIAFACLNGNPQHRPAMQQVAQALYRQSLPLSSPFSTVKLGELLGHVICNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V1S6</accession>
    <name>A0A0D2V1S6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pectate lyase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G439500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V1S6"/>
    <dbReference type="STRING" id="29730.A0A0D2V1S6"/>
    <dbReference type="Gramene" id="KJB62835">
        <property type="protein sequence ID" value="KJB62835"/>
        <property type="gene ID" value="B456_009G439500"/>
    </dbReference>
    <dbReference type="OMA" id="QELMIMV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF184">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253166" description="Pectate lyase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB62835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="300" mass="35258" checksum="BC462EA38B192254" modified="2015-04-29" version="1">MEVTKLRVVFLFSFFTLIPKLWANIAEFDDFWKQREEEAWKIALTAYERCPENVTSHLNYHVNKVLKKTLSNQPFEFKDVITNSTRRSLRDKHKNTSPCMTINPIDRCWRCKKNSKNRKRLSKCYLVADNSDDDVVNPKPRTLRHAVIQKRPLWIIFAPDMNFKLSQELMIMVQSHKTIDSRGSNVYIAYECGITLQFVHNVVIHNIHVHRTVKSNGGLIRDSEDHYGSMHPTIISQGNRFIAPDNPLVKEITHRNYAPESEWRNWIWRAEGDLFMNGAFFCNIWATLTSPFQIQKEGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2H4</accession>
    <name>A0A0D2V2H4_GOSRA</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G452500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2V2H4"/>
    <dbReference type="Gramene" id="KJB63090">
        <property type="protein sequence ID" value="KJB63090"/>
        <property type="gene ID" value="B456_009G452500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768598"/>
    <dbReference type="eggNOG" id="ENOG502QXV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRNCTTK"/>
    <dbReference type="OrthoDB" id="630676at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044839">
        <property type="entry name" value="NDR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31234:SF42">
        <property type="entry name" value="LATE EMBRYOGENESIS ABUNDANT (LEA) HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
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            <begin position="1"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB63090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="30851" checksum="21DB2D98BCA5BD0A" modified="2015-04-29" version="1">MLSPLPSPPPPPPPQSPSPSPTPPSTKYTTPISLSQIVISKPTITQQQEAPSSKKANPNTDTDNDNDNTTTLVRKSLLRQPHPRRTNPLIWCCAIICLIFSVILILFGVATLIIFLSMKPRIPLFDTPNARLNGIYFDTPEYFNGDFTFLANFSNPNKRIDVRFEYLVIELYFHDRLISTQAVQPFYQRSGEVRVEAVHFISSLVYLPQNLGVELQKQVLSNRVTYFIRGTFKVRAHMGLIHFSYWLHARCELLMSSPPTGVLVSHICKTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V6K7</accession>
    <name>A0A0D2V6K7_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G143300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB77554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V6K7"/>
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        <property type="gene ID" value="B456_012G143300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSZR">
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    </dbReference>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="entry name" value="PELPK1_2"/>
    </dbReference>
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        <property type="entry name" value="MUCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33088:SF28">
        <property type="entry name" value="PROTEIN PELPK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="376" mass="42237" checksum="CE60E8F12267E94E" modified="2015-04-29" version="1">MTSNIVLVGARRLLETFVPKLELPKVPELPKLELPKALELPKPELSKTPELPKPELLKVLELPKPELPIVHEVSKPELPKAPELPKLELSKFLELPKSELPKVPEVPKSKLPKAPELPKHESPKVPKLPMPELSRVPEVPKPKLPKALELPKPELQISRPEIPKMLELSKPELPKVSELPKLEFLKFPVLPKLPELQKPKEVNDPELPKPELPKVHEIPKAPKLPKILKLPKPELSKVPEMPKPELPKAPELPKPKLPKVPEAPKPKLPKAPKLPNPKLPKVLELPKSKLPKVPKLLKPELPKAPKLSKPELPKIPELTKPELSKVLKVPKPELPKALELPKIPELPNYLTCQNLKNSKLPKPELPKLSNLETRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VAM8</accession>
    <name>A0A0D2VAM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G149000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66635.1"/>
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        <source>
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    </evidence>
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    <sequence length="308" mass="34490" checksum="5EC9F060B3E46895" modified="2015-04-29" version="1" fragment="single">HTTLVPSAATLLSALCSLLVPYSATLVLSAATLLSALYFVLPSADGWLKIITNFEKETGKGFSQRQLKNRWDALKKEWKAWKKLKGEDTGLGWNPIKRTVDASDEWWESRLQVVPEAKKFKTSGIDPEFEGKLDQMFMGIVATGDKAWAPSSGTLHSDFFEDVNNEIPEESEEENMRNDVHISNDVQIDGNGQKRKNPKTSTSHFKTGRKKSSKQIGGAARLSSQIEKLCNAADNMSQVTSSLTPVMDPYGIPQAVKMLDSMSEEVPEASPLYFFALRLLLNKDKRIMFLSINPKIRALWLKMEMEDS</sequence>
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        <name type="scientific">Gossypium raimondii</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000013">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2VIF1"/>
    <dbReference type="Gramene" id="KJB83501">
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        <property type="gene ID" value="B456_013G250400"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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            <taxon>Malvales</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
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    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cysteine-rich repeat secretory protein family.</text>
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    <dbReference type="EMBL" id="CM001750">
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005576">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="CRR_secretory_protein"/>
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        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32411:SF43">
        <property type="entry name" value="CYSTEINE-RICH REPEAT SECRETORY PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989207" description="Gnk2-homologous domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
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    <feature type="domain" description="Gnk2-homologous" evidence="8">
        <location>
            <begin position="128"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038515"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB70265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0599234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="238" mass="26311" checksum="C4E89507E7808287" modified="2015-04-29" version="1">MSCSRIASFVYLLTLASLLQTAFGLFHNCSDTGSFSAGGPYEANLNQLIEFLSSQTPPSGFGRRAIGQNPNRVFGLALCRGDVSSEDCKTCVVRAGNEIRKQCPYKKGAITWYDDCLVKYSNIGFFGQIDNQNKFNVWNPNKASEAFSRQSEGFLSLLANEASANPTSFYASGEILVHRSMKIYGMTQCTRDLSISDCKKCLDGLIDEFPKCCNQLEGARVFSGSCNFRYENFPFVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJM5</accession>
    <name>A0A0D2VJM5_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_N006000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28309">
        <property type="entry name" value="REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28309:SF1">
        <property type="entry name" value="REQUIRED FOR EXCISION 1-B DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_repr_REX1B"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB84126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="155" mass="17580" checksum="1D0ECA7347A96EFF" modified="2015-04-29" version="1" fragment="single">GFSEYMKSGGELAYQQLCSEITVEFNDCSKQVLEMESLFLNPDYCRVDLAELLRAIQTQEKQKLHLTATIQVLKKAGRPSERLMNHENCSFKKPMEHECVHLQEITEAAGTEEAEANAEYDNALKEAIRGVQDAVTAINEHLEEVRYEIAALETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJS5</accession>
    <name>A0A0D2VJS5_GOSRA</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G246500</name>
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    <organism evidence="2 3">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB83414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2VJS5"/>
    <dbReference type="Gramene" id="KJB83414">
        <property type="protein sequence ID" value="KJB83414"/>
        <property type="gene ID" value="B456_013G246500"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S1SD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33257">
        <property type="entry name" value="OS05G0165500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33257:SF6">
        <property type="entry name" value="OXYSTEROL-BINDING 4B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB83414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="184" mass="20781" checksum="3B66E058F7AE0416" modified="2015-04-29" version="1">MDYDRNRGVSLIQDDQMFFHRIISRDSSVGCSSRIYYYRSSEGIPFNWEMQPGTPKEPQKEDVLPPISPPPALLSLGLPKPRIDVVEESKVSKLKVFKFWKHGKKNDNKKKIDDHQSDKYSNYETCSSDDDGEFVGSPCVSSSSSSSFSFGSSSTPSRDSSFNRHYGCGPLNFASFLVRVSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUD1</accession>
    <name>A0A0D2VUD1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G017200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Mansoor S."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <recommendedName>
            <fullName evidence="14">Malectin-like domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="15" type="ORF">B456_001G208900</name>
        <name evidence="16" type="ORF">Gorai_021610</name>
    </gene>
    <organism evidence="15 17">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M199"/>
    <dbReference type="STRING" id="29730.A0A0D2M199"/>
    <dbReference type="Gramene" id="KJB10587">
        <property type="protein sequence ID" value="KJB10587"/>
        <property type="gene ID" value="B456_001G208900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801764"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RAGNEMK"/>
    <dbReference type="OrthoDB" id="1720310at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000003">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000007">
        <property type="entry name" value="FERONIA receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF15">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220269" description="Malectin-like domain-containing protein" evidence="13">
        <location>
            <begin position="35"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin-like" evidence="14">
        <location>
            <begin position="49"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB10587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0579350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="524" mass="58322" checksum="C44889556745075C" modified="2015-04-29" version="1">MINLTKRYVSQPNKLSVLTLFLFTFLHTLTIASADASPKPYTPHDNIALNCGSTTNTTDLSGRSWISDNTIYLDQSSKVSVISTSPTEGDPIPYTTALLSRSQFTFSFTVTPGPKFIRLHFHPASYRAFNRLNAFFDVHIGGYTVLSNFSAALKADDLKLEVFYSEFCIYVDEEKLNILFNPNPNMPDSYAFINGIEIVSMPNNLYYSSDDDTGFKFVNQVNPYRILKNQALESLYRVNIGGSSISPTQDTGMYRSWSEDGEYVTNGGPSVLPVNLIISPSFSVIPNYSAPVPVYRTARTMGTNKTVNENYRLTWEFRVDSGFTYYVRLHFCEFQVEITELGDRVFQIYIDNIVAEHQADVISWAGGNGVPVYRDYAVMIGRAGNEMKRNLSIALHPAPAWRTRYSDAILNGVEIFKLSNEGNLAGPNPQTIPISSPKISVPPPTRPKYNLRTTFLTVIGVVSSFVVVSALYILIFRPKSRGEGSSSWSQLSCKDYSSMDGSGKVYSSVGNHSKDTTSVADNKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M726</accession>
    <name>A0A0D2M726_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tubby-like F-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G054300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TUB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M726"/>
    <dbReference type="STRING" id="29730.A0A0D2M726"/>
    <dbReference type="Gramene" id="KJB13052">
        <property type="protein sequence ID" value="KJB13052"/>
        <property type="gene ID" value="B456_002G054300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777332"/>
    <dbReference type="eggNOG" id="KOG2502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWPGRKN"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.90.10">
        <property type="entry name" value="Tubby Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025659">
        <property type="entry name" value="Tubby-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000007">
        <property type="entry name" value="Tubby_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018066">
        <property type="entry name" value="Tubby_C_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517:SF50">
        <property type="entry name" value="TUBBY-LIKE F-BOX PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16517">
        <property type="entry name" value="TUBBY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01167">
        <property type="entry name" value="Tub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01573">
        <property type="entry name" value="SUPERTUBBY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54518">
        <property type="entry name" value="Tubby C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01200">
        <property type="entry name" value="TUB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01201">
        <property type="entry name" value="TUB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubby C-terminal" evidence="4">
        <location>
            <begin position="124"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="389" mass="43454" checksum="8321F9B86833272C" modified="2015-04-29" version="1">MSCSSPMRKTSCLSRRFSRSLRLSARTAALTTVSTRENHLESSSTSSPSSPPPLAEAGGDSWSTLLPELLVEIMERVEASEEMWPDRKNVVSSACVCKKWREVTREIVKASSQNSGKITFPSCLKQPGPREFPNQCIIKRNKKNSTFFLYLALSPSFTEKGKFLLAARRYRHGAHIEYIISLDPNELSQGSNAYVGKLSSDFLGTNFKIYDSQPPHSGAKPSSSRASRRFASKQICPQVPAGNFEVGQVSYKFNLLKSRGPRRMVCSIQCPLPEDMADEKYLDDIKMKMPEHASSGHTILRNKAPRWHEHLQCWCLNFHGRVTVASVKNFQLAATVEESQLGGKEEEETVLQFGKVGDDTFTMDYRQPLSAFLAFAICLTSFGTKLACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M8P4</accession>
    <name>A0A0D2M8P4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G094600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M8P4"/>
    <dbReference type="STRING" id="29730.A0A0D2M8P4"/>
    <dbReference type="Gramene" id="KJB13791">
        <property type="protein sequence ID" value="KJB13791"/>
        <property type="gene ID" value="B456_002G094600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB13792">
        <property type="protein sequence ID" value="KJB13792"/>
        <property type="gene ID" value="B456_002G094600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781319"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21293">
        <property type="entry name" value="CH_AtFIM_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21299">
        <property type="entry name" value="CH_AtFIM_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21302">
        <property type="entry name" value="CH_AtFIM_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000045">
        <property type="entry name" value="Fimbrin-1 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000041">
        <property type="entry name" value="Fimbrin-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000034">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF62">
        <property type="entry name" value="FIMBRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="122"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="268"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="393"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="514"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="637"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="699" mass="77788" checksum="F9C95D00425FBD23" modified="2015-04-29" version="1">MSSYVGVLVSDQWLQSQFTQVELRSLNSKFVSVKNQNGKVTVGDLPPLMVKLKAFSALLTEDEIRLILGESYGDMSSEIDFETFLRVYLNMQGQATGKLGGPKNSSSFLKASTTTLLHTISESEKASYVTHINIYLADDPFLKQFLPLDPATNDLFHLAKDGVLLCKLINVAVPGTIDERAINTKRVLNPWERNENHTLCLNSAKAIGCTVVNIGTQDLVEARPHLVLGLISQIIKIQLLADLNLKKTPQLVELVEDSNADVEELMGLAPEKVLLKWMNFHLNKAGYEKTVANFSSDVKDGKAYAYLLNVLAPEFCNPLTLDTKDPVERAKLVIDHAERMGCKRYLSPKDITEGSTNLNLAFVAQIFHERNGLSTDSKKISFAERMTDDVQISREERCFRLWINSLGIESYVNNVFEDVRTGWILLEVLDKVAPGSVNWKHASKPPIKFPFRKVENCNQVVKIGRQLKFSVVNLGGNDIVQGNKKLIVAFLWQLMRFNMLQLLKSLRSRSRGKEITDADIMNWANRKVKSTGRSTQIESFKDKSLSTGLFFLELLSAVEPRVVNWNLVTKGESDEEKRLNATYIISVARKLGCSIFLLPEDIMEVNQKMILTLTASIMYWCLQHAAEEGEVALSPANGNGSTYTSDTSPAPSISGEDERSSLCGEISSLTMDDAASDITVSSSQCENEDTEIATAESHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MAW1</accession>
    <name>A0A0D2MAW1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G141700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MAW1"/>
    <dbReference type="STRING" id="29730.A0A0D2MAW1"/>
    <dbReference type="Gramene" id="KJB14747">
        <property type="protein sequence ID" value="KJB14747"/>
        <property type="gene ID" value="B456_002G141700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EIVDDQK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF781">
        <property type="entry name" value="MYOSIN-15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB14747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="163" mass="18313" checksum="23A508FB646AE6BE" modified="2015-04-29" version="1">MKFNIANLSMGCQKKLEIVDDQKLSTQYLIIIARGLQMWNLFSTAWPCSNTFFYAHRCDVNLLLATLCTRTIQTREGSIVKALDCNAVVASRDALAKTVYARLFDCLVDKINISVGKYPNSHVQIGVLDIYGFECFKHNRWGLENTIKGKTSDMVIPNQAVAS</sequence>
</entry>
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    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB16332.1"/>
        </source>
    </evidence>
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        <source>
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        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2MEV1"/>
    <dbReference type="Gramene" id="KJB16472">
        <property type="protein sequence ID" value="KJB16472"/>
        <property type="gene ID" value="B456_002G231500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786253"/>
    <dbReference type="eggNOG" id="KOG4282">
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    </dbReference>
    <dbReference type="OMA" id="APIMARP"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:glucosinolate metabolic process"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:mucilage biosynthetic process involved in seed coat development"/>
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        <property type="project" value="EnsemblPlants"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
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        <property type="entry name" value="FI21293P1"/>
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    <dbReference type="PANTHER" id="PTHR21654:SF59">
        <property type="entry name" value="TRIHELIX TRANSCRIPTION FACTOR DF1"/>
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        <property type="entry name" value="SANT"/>
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    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="58"/>
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    <feature type="domain" description="Myb-like" evidence="8">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="410"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0581325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="475" mass="53739" checksum="DE2AD22E7AF662B3" modified="2015-04-29" version="1">MLGGGGTTASVSSGGGCNGSNEAAAPVAVFDTNDGNSNNSGKDDRSKVDEGDRSFGGNRWPRQETLALLKLRSDMDVTFREASVKGPLWEEVSRKLAELGYHRSAKKCKEKFENVYKYHKRTKDGRSGKADGKTYRFCDQLEAFQNQPSIQWPPPPPVAAAATINQSISAVQMSNSTSSSTSSDLELQGRKKRKRKWKDFFERLMKEVIQKQQVMQKTFLEAIEKHERERIVRDEAWKVQEMSRLNREREILAQERSIAAAKDAAIMAFLQKLSEKQNLGQSQNSPLPPPAVVPAAVAPPPDNGNQIQTHTPSSSRWPKVEIEALIKIRTSLDSKYQDNSPKGPLWEEISNGMKKLGYNRNAKRCKEKWENINKYFKKVKESNKQRPVDSKTCPYFHQLDVLYREKNKHDCSSKSNPLMVRPEKQWPPPLEPHQQHHDTIMEDMMESDQNDDEEEDEGGSYELVASKPVSMGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MI64</accession>
    <name>A0A0D2MI64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G020400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MI64"/>
    <dbReference type="STRING" id="29730.A0A0D2MI64"/>
    <dbReference type="Gramene" id="KJB17867">
        <property type="protein sequence ID" value="KJB17867"/>
        <property type="gene ID" value="B456_003G020400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787588"/>
    <dbReference type="eggNOG" id="ENOG502S3WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNGTACA"/>
    <dbReference type="OrthoDB" id="635132at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039218">
        <property type="entry name" value="REM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674:SF62">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="326"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="261"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB17867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="432" mass="48704" checksum="3BF37273117E9869" modified="2015-04-29" version="1">MTRKPKRSPSFFKVLIGDFDNKLRIPPAFVKYVLKGNVPTMFTLYSDSGNSWRVRVMVEQGSYFFNSGWSKFVKHHDLEIGDFLVFFLVDTSTFDVLIYNGTACAKNIILAAKKRKCLPPLANRQIEETPSQKCASVSKKPRAVYRARSVSQEVESITEVTRKHVSFVMVVKKYHKYFACVPRCFAKETGLLKESITLIKGPRGGMWPMNTTECGKQVRLGGGWSRFLHENEIVVGDTLLFEHIPSKGNLVHVQIVNKDRYRNRGRRNKQADASVKNTSPAAKRPRVRPGKQIEEPPSTKHAPSSKRTKGVSIGNDEIVSELTPKKASFVMVLKEYQKYSAVVPTSFAKEMGLAEKPSTIIKNSKGRKWLLNTIVDAKSQVRLGAGWSQFVQENKLELGDTLLFQHIPNTGNVINLTIICKVGDGNNRKRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ML94</accession>
    <name>A0A0D2ML94_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G087900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ML94"/>
    <dbReference type="STRING" id="29730.A0A0D2ML94"/>
    <dbReference type="Gramene" id="KJB19182">
        <property type="protein sequence ID" value="KJB19182"/>
        <property type="gene ID" value="B456_003G087900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788312"/>
    <dbReference type="eggNOG" id="KOG1548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009910">
        <property type="term" value="P:negative regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000329">
        <property type="entry name" value="splicing factor U2AF-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025640">
        <property type="entry name" value="GYF_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the Iojap/RsfS family.</text>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NTD5"/>
    <dbReference type="STRING" id="29730.A0A0D2NTD5"/>
    <dbReference type="Gramene" id="KJB17148">
        <property type="protein sequence ID" value="KJB17148"/>
        <property type="gene ID" value="B456_002G267100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786596"/>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIAQTCA"/>
    <dbReference type="OrthoDB" id="294295at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05326">
        <property type="entry name" value="secoisolariciresinol-DH_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045309">
        <property type="entry name" value="ABA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF41">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE REDUCTASE 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0581574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="306" mass="32535" checksum="66F8EF9B4A3565CD" modified="2015-04-29" version="1">MTMPAQVIPDKTLQGLHGLGRENSSSPHPRRLEGKVAIVTGGARGIGEATVRLFARHGAKVVIADVEDTLGTALANSLSPCVTFVHCDVSLEEDIENLVSSTVSRYGRLDILFNNAGVLGNQRKHKSIVDFDVDEFDNIMRVNVRGMALGIKHAARAMIPRGGGCIISTASVAGVMGGLGPHAYTASKHAIVGLTKNAACELGRYGIRVNCISPFGVATPMLVNAWRSHDDEEEETGFNFGIPCQQETEKTEEFVRGLANLKGPTLRAKDIAEAALYLAGDESKYVSGHNLVVDGGVTTSRNCVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NWT5</accession>
    <name>A0A0D2NWT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G222400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYB-CC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NWT5"/>
    <dbReference type="STRING" id="29730.A0A0D2NWT5"/>
    <dbReference type="Gramene" id="KJB37832">
        <property type="protein sequence ID" value="KJB37832"/>
        <property type="gene ID" value="B456_006G222400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVJ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025756">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046955">
        <property type="entry name" value="PHR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR PHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499:SF6">
        <property type="entry name" value="PROTEIN PHR1-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14379">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB37832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="253" mass="28124" checksum="D3E3A5E6305F001A" modified="2015-04-29" version="1">MYSAIRSLPLDGSVGDYEGSFDGTNLPSDACLVLTTDPKPRLRWTAELHERFVDAVTQLGGPDKATPKTIMRTMGVKGLTLYHLKSHLQKYRLGKQSCKESTDNSKDASCVAESQDTGSSTTSSSKLVAQDLNDGYQVTEALRVQMEVQRRLHEQLEVQRRLQLRIEAQSKYLQTILEKACKALSDHVAASAGLEAAREELSELGIKISNDFQGMVPFDNIKLPSLPELPAALENKATTTDWYYEEETQALVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P0B9</accession>
    <name>A0A0D2P0B9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G025200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P0B9"/>
    <dbReference type="STRING" id="29730.A0A0D2P0B9"/>
    <dbReference type="Gramene" id="KJB39132">
        <property type="protein sequence ID" value="KJB39132"/>
        <property type="gene ID" value="B456_007G025200"/>
    </dbReference>
    <dbReference type="OMA" id="NELPMAS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB39132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="153" mass="17109" checksum="A25884B0586409F8" modified="2015-04-29" version="1">MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPPDSPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVIVQHVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYETTARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4P4</accession>
    <name>A0A0D2P4P4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G074300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4P4"/>
    <dbReference type="STRING" id="29730.A0A0D2P4P4"/>
    <dbReference type="Gramene" id="KJB40707">
        <property type="protein sequence ID" value="KJB40707"/>
        <property type="gene ID" value="B456_007G074300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802423"/>
    <dbReference type="eggNOG" id="KOG1515">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDCVAND"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF639">
        <property type="entry name" value="CARBOXYLESTERASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="151"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB40707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="443" mass="49218" checksum="6311A8A34E903BB6" modified="2015-04-29" version="1">MPSIAVKLYSVFFKFLLKHRLQNRIQTHVDESSNQYGVTTRPEESVSAANPSFTDGIATKDIHIDPSTALSVRIFLPESSLSPPEPKSKPGSSQQDESDSLNHRRNSYPNIGARTNDSRRSSLEGSKLRSDNNVYRGYSPLPQNCRRLPIMLQFHGGGWVSGSNDSVANDIFCRRIAKLCDVIIVAVGYRLAPENKYPAAFEDGLKVLYWLAKQANLAECSKSMGSGALGVGAEFTKTQVQRHLVDAFGASMVEPWLAAHGDPSRCVLLGVSCGANIADYVARKAVEAGRLLDPVKVVAQVLMYPFFIGNVPTRSEINLANSYFYDKPMCLLAWKLFLPEEEFRLDHPAANPLVPDRGPPLKFMPPTLTVVAEHDWMRDRAIAYSEALRKVNVDAPVLEYKDAVHEFATLDMLLNTPQAQACAEDIAIWVKKYISLRGHEFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P592</accession>
    <name>A0A0D2P592_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G082400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P592"/>
    <dbReference type="STRING" id="29730.A0A0D2P592"/>
    <dbReference type="Gramene" id="KJB40917">
        <property type="protein sequence ID" value="KJB40917"/>
        <property type="gene ID" value="B456_007G082400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITYPEQG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF1412">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 83A1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB40917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="152" mass="16438" checksum="131BD242974039D7" modified="2015-04-29" version="1">MGKPHVVVIPYPAQGHVISVMELSQNLAKQGIKINFKVDENGLIHLLSVPDGLEDGEDRNQLGKLTESLYQVMPTQPKELIHKVNGLNDDKISCVLVDIGMGLALDVAAELGIPTVGLWPAAVLQLAVLLKVPKLIDDGLIDENGNTYLVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P5G3</accession>
    <name>A0A0D2P5G3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G021700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P5G3"/>
    <dbReference type="STRING" id="29730.A0A0D2P5G3"/>
    <dbReference type="Gramene" id="KJB21923">
        <property type="protein sequence ID" value="KJB21923"/>
        <property type="gene ID" value="B456_004G021700"/>
    </dbReference>
    <dbReference type="OMA" id="WIHNDDE"/>
    <dbReference type="OrthoDB" id="591557at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013187">
        <property type="entry name" value="F-box-assoc_dom_typ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08268">
        <property type="entry name" value="FBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="369" mass="43119" checksum="A8AA4A148BDEC736" modified="2015-04-29" version="1">MARLPHEVTSDILCRLSVKDLLRFRSVSKPWCRTIDDPYFIKLHLSHSLKTITNHSLILSHWEDHFFSVDYDLFETTQRLNHPFGERRKTLQILGSCNGLLALVDDKDGIFLWNPSTRKSQVLPFNEIGFSSPSSSYYGFGYDPISDEYKLVRMVQSHGNNDEYFHSEAKVYSLRSNCWRRIKDVCFYHKFSREFGFLANNALHWMVFKTPQSRNQELVGFDLGSEEFRFLELPDGCLDKILRFHIKAMGGDICLTSTYRETNNFVVDVWIMKEYGVKQSWFKLISWKEPYFMPCSIVALPVAFSKDGDEVLFFIGYKWFNWGRRIDSFVWYDLGSQVVEDAVIRGIPTSFDVNLYVDSLVPLNSNAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P7N8</accession>
    <name>A0A0D2P7N8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDSL esterase/lipase At1g09390-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G120400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P7N8"/>
    <dbReference type="Gramene" id="KJB41772">
        <property type="protein sequence ID" value="KJB41772"/>
        <property type="gene ID" value="B456_007G120400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTD0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MNDATIV"/>
    <dbReference type="OrthoDB" id="655468at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835:SF158">
        <property type="entry name" value="GDSL ESTERASE_LIPASE LIP-4-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22835">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB41772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43095" checksum="9F86C6D387547525" modified="2015-04-29" version="1">MIVVKENASKLDMGVVKGGRYLLVPFFTLYMILFLYLPLLPHSVHCQCTKTPIIFNFGDSNSDTGGYADGVGLNFAPPNGRTYFHQPARRLSDGRLMIDFLCESLNTDYLTPYLNSLEPNFTNGVNFAIIGSATLPRYVPFSLFVQVSQFLRFRYRSPALMLNGYKDLVGDEDFENALYTIDIGQNDLAASFDNLTYSQVIERIPSFITEIKNAIWNIYEKGGKKFWVHNTGPLGCLPQKLALLARNATELDEHGCLQPLNNAAKTFNAQLRVLCEQLRRELINVTIVYVDIYSIKYDLIANASNYGFESPLMACCGNGGPPYNYNANINCGRTGYTVCHEGSKFISWDGVHYTEAANAIFASKILSTHYSTPQLSFNFFCNNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PEL3</accession>
    <name>A0A0D2PEL3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">60S ribosomal protein L37a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G190800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Dennis E.S."/>
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                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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</entry>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
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                <person name="Guo H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="15" mass="1631" checksum="DE04C171F114F644" modified="2015-04-29" version="1" fragment="single">METEVMVAGSIDDSF</sequence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Reddy U.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
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    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB10144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="72" mass="8114" checksum="100ABE7D1D436509" modified="2015-04-29" version="1" fragment="single">LAASQHFLFFFFTTQFTTVVKSALQAIRERGLRTFLRELKDDGFTKCFFDGNLLVILLPIEAACLIASSTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTV3</accession>
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            <fullName evidence="3">DUF688 domain-containing protein</fullName>
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        <name evidence="1" type="ORF">B456_008G126300</name>
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    <organism evidence="1 2">
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        <lineage>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTV3"/>
    <dbReference type="Gramene" id="KJB49582">
        <property type="protein sequence ID" value="KJB49582"/>
        <property type="gene ID" value="B456_008G126300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763915"/>
    <dbReference type="eggNOG" id="ENOG502RXG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PWSKRGK"/>
    <dbReference type="OrthoDB" id="1934555at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007789">
        <property type="entry name" value="DUF688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34371:SF2">
        <property type="entry name" value="DUF688 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34371">
        <property type="entry name" value="OS01G0551000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05097">
        <property type="entry name" value="DUF688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB49582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23789" checksum="03A6471773530563" modified="2015-04-29" version="1">MGSKAEKEWSSTSKLPLFSSPHAHMQSPEKQWVLTPPHHALASVPFRWEEEPGKPKPCCTTTLTTTYDLGRKCLELPPRLLILDAAKNTAGGKLYSPTTVLDGPYMGKARFQSSSFRIGSECYGSFRSGSFSPENMVVHGGSGGGAMVVSSKRVKRDKGFLGSRRRDVFPSFGDEYGSSFNTLSRSKSHFWGSIYQGLKQVVPWSKRGKKDRFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVY3</accession>
    <name>A0A0D2PVY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_001G079200</name>
        <name evidence="18" type="ORF">Gorai_020771</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PVY3"/>
    <dbReference type="Gramene" id="KJB08376">
        <property type="protein sequence ID" value="KJB08376"/>
        <property type="gene ID" value="B456_001G079200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788402"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWITWLI"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000005">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000058">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000001">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF62">
        <property type="entry name" value="OS05G0423500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715550" description="Protein kinase domain-containing protein" evidence="15">
        <location>
            <begin position="29"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="540"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0578492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="874" mass="97494" checksum="068518B416C65BE1" modified="2015-04-29" version="1">MGEDHNMPSFMPLSILSLSLYLLTLNHAYVLLAPAPSPVSISSPPSAYQPYDSYLINCGSSTETRLDDGRIFKSDTQAHSYLSTNQDVKASMDYIPSDAFSNSIPSSTEGLYKTARVFLHRSTYTFYISKPGKHWVRLYFYPLHHPHYDLETAVFTVHTEKFVLLHDFSVRGYSKVVFKEYLVNAIELFSLVFEPKKGSYAFVNAIEIAAVPDEFISDTASSVPQGETVNGLSNYALEVSYRLNMGGPILTPKYDTLSRTWMPDTPYNVFPQGTEAVRGSYIKYQPDKWITWLIAPYLVYETAQRMKTEAHAQTVEPKFNLTWVVNVDAGFSYLIRMHFCDIVSKSLNDLYFNVYINSLMGFSSLDLSAETGGLATAYYIDFVLNASAITNGSIVVQVGPASTGGLPNAILNGLEIMKINNVDDSLDGLYAVDGSYEGKFMKLKVLAISGIFMAFLAMFFLGIVCVRWKKRPPDWQKRNSFSSWLLPIQGSSRKNSLSSSWKSSIFGSRKSKSGHSSYYSIQGLGRFFTLNELRTATHNFDEKIVIGVGGFGNVFLGALEDGTKVAIKRGHQGSEQGINEFQTEIEMLSKLRHRHLVSLIGFCDEESEMILVYEYMANGPLRDHLYGSNDKLTLSWKQRLDICIGAARGLHYLHTGAAIGIIHRDVKTTNILLDDNFVAKVSDFGLSKAAPMEQGYVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVLFEVLSARAVICPRLPRDQISLAEWAMQWHRKGMIEKIVDPQIAGSISEGSLKKFAETAEKCLAEYGVDRPSMGEVLWYLEYSLQLQEATIASSSSSSSNINDLLEEKLSKNVVSIANILSDDDSDSTVGSQLHFPNVGNMQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYJ5</accession>
    <name>A0A0D2PYJ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">26S proteasome regulatory subunit RPN7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G204800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYJ5"/>
    <dbReference type="STRING" id="29730.A0A0D2PYJ5"/>
    <dbReference type="Gramene" id="KJB51167">
        <property type="protein sequence ID" value="KJB51167"/>
        <property type="gene ID" value="B456_008G204800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764775"/>
    <dbReference type="eggNOG" id="KOG0687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VELGWEM"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="191"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00075096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB51167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="387" mass="44824" checksum="AE5F4A0CE6C73E5D" modified="2015-04-29" version="1">MDAQEGTQQSQQLILAHKVFLLKHRDVPDIEKVRLKDEVLNTVKSNYMTPYYENLVADKVLDLDHSVLDSMRAKNEEEIKKIDEKIADAEENLGESEVREAHLAKFLYFIQIGEKEKALEQLKVTENKTVAVGQKMDLVFYSLQIGFFYMDFDLISKSIDTAKNLFEKGGDWERKNRLKVYEGLYCMSTRNFKKAANLFLDSISTFTTYELFPYDTFIFYTVLTSIISLDRVSLKQKVVDAPEILTVIGKIPHLSEFLNSLYNCQYKSFFLAFAGLTEQIKMDRCLHLHFRFYMREIRTVVYSQFLESYKSVTIEAMAKAFGVTVEFIDQELSRFIAAGKLHCKIDKVAGVLETNRPDAKNALYQVTIKQGDFLLNRIQKLSRVIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q2A3</accession>
    <name>A0A0D2Q2A3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G2116001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q2A3"/>
    <dbReference type="Gramene" id="KJB10621">
        <property type="protein sequence ID" value="KJB10621"/>
        <property type="gene ID" value="B456_001G2116001"/>
    </dbReference>
    <dbReference type="OMA" id="DASSEWW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47851:SF1">
        <property type="entry name" value="OS06G0588700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47851">
        <property type="entry name" value="OS06G0588700 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="57" mass="6979" checksum="92D0558D97066DE9" modified="2015-04-29" version="1" fragment="single">MLWKTIEVQFQKKTSLVYDKAKLKNKWGWMRNRWSLWKALKRKETGLGWDHEKGTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q6W2</accession>
    <name>A0A0D2Q6W2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G023700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q6W2"/>
    <dbReference type="STRING" id="29730.A0A0D2Q6W2"/>
    <dbReference type="Gramene" id="KJB12511">
        <property type="protein sequence ID" value="KJB12511"/>
        <property type="gene ID" value="B456_002G023700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774547"/>
    <dbReference type="eggNOG" id="KOG0834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WQEFQAT"/>
    <dbReference type="OrthoDB" id="10264655at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000150">
        <property type="entry name" value="Cyclin-T1-3 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000104">
        <property type="entry name" value="cyclin-T1-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="172"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="287"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="372" mass="42925" checksum="4B7839548C9A557C" modified="2015-04-29" version="1">MSFTRNCRMQGSVFQDDYRCPFNRNNYNNYSSDNYRNGNWSSDPTRIFNHAQEFLGQFGEHNRGYHHAQPNCAPSLKRRKFSAATWGDSGRNYQPYSLQFPTAPLEPSNFIPPPVRSTAEASTSVSNKRDRSQLEDDESVFMSRDDIERYSPSRRDGIDALRETHLRYSYCAFIQNLGLQLELPQTTIGTAMVLCHRFFVRRSHACHDRFLIATAALFLAAKSEETPRPLNNVLRTSCEIFHKQDITFLSYLLPVDWFEQYRERVIEAEQMILTTLNFELNVQHPYAPLTSILNKLGLSQTALVNLALNLVSEGLRSSLWLQFKPHHIAAGAAYLAAKFLNFDLASYHDIWREFQTTPAILQDVSQQLMELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q788</accession>
    <name>A0A0D2Q788_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G158100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q788"/>
    <dbReference type="SMR" id="A0A0D2Q788"/>
    <dbReference type="STRING" id="29730.A0A0D2Q788"/>
    <dbReference type="Gramene" id="KJB15054">
        <property type="protein sequence ID" value="KJB15054"/>
        <property type="gene ID" value="B456_002G158100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0407">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="16353" checksum="B75B6966E69EBF91" modified="2015-04-29" version="1">MSRRKVREPKEENTTLGPAVRDGEHVFGVAHIFASFNDTFIHVTDLSGRETMVRITGGMKVKADRDESSPYAAMLAAQDVSQRCKELGITALHIKLRATGGNKTKTPGPGAQSALRALARSGMKIGRIEDVTPIPTDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8L7</accession>
    <name>A0A0D2Q8L7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_002G064800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8L7"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8L7"/>
    <dbReference type="Gramene" id="KJB13246">
        <property type="protein sequence ID" value="KJB13246"/>
        <property type="gene ID" value="B456_002G064800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778511"/>
    <dbReference type="eggNOG" id="ENOG502QV8Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFCTATH"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
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    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF36">
        <property type="entry name" value="SODIUM_CALCIUM EXCHANGER MEMBRANE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002261425" description="EF-hand domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="11">
        <location>
            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="578" mass="63537" checksum="AA03EF36619EB254" modified="2015-04-29" version="1">MTSKHFLFLFFFIFCFSSFPSHARFITGRPSPTGLVSDGISTVKNLPYLLLKPPVSAEESCEQSYGFLPCTTTVLGNMFLIIVYGYLMYLAATYLSYGSELLLEILGPGIVGGLFLPMLGALPDAMLILVSGLSGTAETAQSQVSVGMGLLAGSTVMLLTVIWGSCIIVGRCDLHDSVAIDGTNTKGFNLKESGVSTDIWTCYAARIMAISVIPFLIVQLPQALSSTSGRHLAVLIALVISLLMLISYCVYQVFQPWIQRRRIAFAKHKHVISGILRHLKKHGLGRLLTDDGEPDTEIIRKLFETIDENHDGGLSPSELRALIIGIRFEEIDLDQDDAVSKVIADFDTSRDNLVQEDEFVEGIMKWINEAKQTGGAYLESNAGTFKFIDHFHQQTKREHALLGSEEQSDEVVENVENPRWISIKAVLMLLLGTLIAAAFADPLVDAVDNFSEATSIPSFFISFIALPLATNSSEAVSAIIFASRKKQRTASLTFSELYGAVTMNNVLCLSVFLALVYVRGLTWDFSSEVLVILIVCVVMGAFASFRTTFPLWTCSVAYILYPFSLGLVYVLDYVFGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QES7</accession>
    <name>A0A0D2QES7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G220700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QES7"/>
    <dbReference type="STRING" id="29730.A0A0D2QES7"/>
    <dbReference type="Gramene" id="KJB37803">
        <property type="protein sequence ID" value="KJB37803"/>
        <property type="gene ID" value="B456_006G220700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14704">
        <property type="entry name" value="bZIP_HY5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB37803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="67" mass="8095" checksum="503C3E6FE7364C46" modified="2015-04-29" version="1" fragment="single">DPIAKKQKRQLRNRDAVVRSRERKKMYVKDFEMKSRYLEGECRRLSHVLQCFSAENQALQIFFFSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFS6</accession>
    <name>A0A0D2QFS6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G049400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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        <property type="entry name" value="NON-FUNCTIONAL PSEUDOKINASE ZED1-LIKE"/>
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    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB18374.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="340" mass="37770" checksum="ADCA230993BC02A8" modified="2015-04-29" version="1">MLKEGEMGSCFRIKRQGKDEGPLLKNGSMLLEKLIASSDGKCNPICTFSAEELSEATKGYDVGQEISRYVHFVLYKGFLRGRELSVKRYGSYNKCLETAITDIVISSQMSVHKNVLKLIGCCLETQNPVLVYEYGGEKNLQRLMFDVSDGQLEPLTWKSRIKIAMDIANAVAYLHTALSRPVINRGLSLISIVIDTNYVAKLADFSLSVAIPKGKSHAVEDAISGVVGYIAPEVLECKINEKADVYSFGILLLELLTRRKSGDHSVEEAPFRAFVSNYVESNRLTEIVDQSILSERSNGNELVSLAKIALCCTQENPENRPMITDVAKQLRQLNKDCKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGH1</accession>
    <name>A0A0D2QGH1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">Nuclease associated modular domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G148300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003611">
        <property type="entry name" value="NUMOD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199">
        <property type="entry name" value="NUMOD3 MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34199:SF2">
        <property type="entry name" value="NUMOD3 MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07460">
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        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="71"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="355"/>
            <end position="393"/>
        </location>
    </feature>
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    </feature>
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            <begin position="317"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF07460"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB57102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="572" mass="64422" checksum="15E0A6FA505846EE" modified="2015-04-29" version="1">MPLLDIASAQPSLQGPLVPVRVQTLFHGQLLSNPWKSSKLPKRVNFSVGHLENPSGRLQIRAVATLEPKCSVPKEDEHNKSQLGGDSSPSSTRLESLKSGDSDEEPDEREKLRRMRISKANKGNTPWNKGRKHSAETLQRIRERTRLAMQNPKVRMKLVNLGHTQSKETREKIGTGVRMGWEKRREKLMVQETCHFEWMNLIAEASRKGYLGEEELQWDSYKVLDEQLVKEWLESVEQRKTMPRPKGSKRAPKSLEQRRKIAAAIAAKWADPDYRERVCSGLAKFHGVSDGAERKPKRKPTTSSQSRQSPSKKKANETNYSTTSETISPIERLRMRRRNKPLYMDPMASSKLEMLKNIRAQRAAEELKKTEAVEQARLLIAEAEKAAKALEIAAMKSPVAQASLIETRKLIAEAIQSIESIEGGCVTSNENGGYISVDSAEPVGQVEKKMQSEKSTLSQSDQKEVNGNQFLSLSKNEDFNFHNFMFPRIVNGDSDEQLTSPGLNNYSLSTLDFQSLIKESDSPKQFNQLETNRIINGTKVELKDNNVASKAVAAVTKKWVHGRLVEVIEEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QH58</accession>
    <name>A0A0D2QH58_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">DUF1685 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G161100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="STRING" id="29730.A0A0D2QH58"/>
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        <property type="gene ID" value="B456_009G161100"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502RYMY">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
    <dbReference type="InterPro" id="IPR012881">
        <property type="entry name" value="DUF1685"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33785:SF12">
        <property type="entry name" value="DUF1685 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33785">
        <property type="entry name" value="OS06G0550800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07939">
        <property type="entry name" value="DUF1685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB57387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="28012" checksum="2AA7FF745DF466F3" modified="2015-04-29" version="1">MESDGIISLFDSCWFEMEIFKKQTTPSTSTVSEPNQDLRAEETSSKPEFTRTPSLHTRSMSDQLSLNSTSFIGSASLSPDSVLHSPKLHKIISGKEMTEEELQDNGSRIQEEPKKKETAASNRRSSRRKKGTSKSLSDLEFEELKGFMDLGFVFSEEDNKDSRLVEIIPGLQRLGRKDGEEENKEAAGAEDDDRDEVSRPYLSEAWHVSERRKENPLMNWRVPALGNEVDVKDSLRWWAHTVASTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIP6</accession>
    <name>A0A0D2QIP6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G188100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QIP6"/>
    <dbReference type="STRING" id="29730.A0A0D2QIP6"/>
    <dbReference type="MEROPS" id="M14.A01"/>
    <dbReference type="Gramene" id="KJB57967">
        <property type="protein sequence ID" value="KJB57967"/>
        <property type="gene ID" value="B456_009G188100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771445"/>
    <dbReference type="eggNOG" id="KOG2650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWCASFF"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06227">
        <property type="entry name" value="M14-CPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000064">
        <property type="entry name" value="Carboxypeptidase A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034269">
        <property type="entry name" value="At5g42320_M14_CPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF119">
        <property type="entry name" value="OS02G0119300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="5">
        <location>
            <begin position="43"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB57967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="351" mass="39704" checksum="8246B83134D81EA5" modified="2015-04-29" version="1">MAASYHLFFIIYLSGFAAFPIFSFVYANANTTQHSWTPINHHLYHSGEGLIEKIKSLVHRHPDKLTVETIQAGTKDYKADITVVTYSQNWEQSDDKSKLRILLSFGQHARELISSELALRILSALGEEQFPPEMDPASLHDTLENVVIKIVPIENLNGRKIVDAGELCERRNGRGVDLNRNWAVDWGKKEKDYDPAEEYPGTAPFSEPETQIMRELAVSFNPHIWVNVHSGTDGLFMPYDHKKSTPDGLPSQRMRELLDELNVLYCSKRCLVGSGGTAVGYLAHGTATDYMYDVVRVPMAFTFEIYGDDKASGADCFKMFNPIDQTTFKRVMDQWCASFFTLFKLGPVCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKE9</accession>
    <name>A0A0D2QKE9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="12">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G139100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="12"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QKE9"/>
    <dbReference type="Gramene" id="KJB20224">
        <property type="protein sequence ID" value="KJB20224"/>
        <property type="gene ID" value="B456_003G139100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788913"/>
    <dbReference type="eggNOG" id="KOG0261">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVCPPYN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="249"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB20224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1398" mass="155419" checksum="C87F2514D850ECBF" modified="2015-04-29" version="1">MQQRSQDIVFTKRPYIEDVGPRRIKSIKFSMFSDSEIAKAAEVQVYKGVYYDLQSRPIEGGLLDPRMGPPNKSGKCATCDGSFGDCPGHYGYLPLVLPVYNVGYLSTILDILKCICKSCSRILLDDKLAKDYLKKMRAPKTEPLKKAEIMKSVVKKCTAMAGGKAVKCSRCGYLNGTVKKAPKMIGVFHDRSKVNDNSLEELKSAISHTKESKSSINTSSVLNPVKVLSLFKRMTDVDCELLYLSDRPEKFIITNIAVPPTAIRPSVPVDGSQSNENDITERLKRIIQANSSLRQQLVDSNAAFHCLNGWDLLQVDVAQYINSDVRGVPTEMQPARPLSGFLQRLKGKQGRFRGNLSGKRVEFTGRTVISPDPNLKITEVAIPIHMARILSYPERVSSHNIEKLRQCVRNGPSKYPGAVKVRYPDGSARLLIGDYRKRLADELKFGCIVDRHLEDGDIVLFNRQPSLHRMSIMCHRARIMPWRTLRFNESVCNPYNADFDGDEMNMHVPQTEEARTEALMLMGVQNNLCTPKNGEVLVASTQDFLTSSFLITRRDTFYDRATFSLICSYMGDAMDLIDLPTPTLLKPVELWTGKQLFNVLLRPHASVRVYLNLTVKERNYSRKIAKRIGDKEIEVETMCPNDGFVYIRNSELLCGQLGKATLGNGNKDGLYSILLRDYNAHAAATCMNRLAKMSARWIGNHGFSIGIDDVQPGKRLNDAKGVTLSGNYKKCDEQIQMFNEGKLQLKPGCDAAQTLEANITEVLNKIRDETGKVCMRELHWRNSPLIMSQCGSKGSAINISQMIACVGQQSVGGRRAPNGFIDRSLPHFHRGSKTPAAKGFVANSFYSGLTATEFFFHTMGGREGLVDTAVKTAETGYMSRRLIKALEDLSIHYDNTCRNASGCIVQFIYGDDGMDPASMEGKSGFPLNFDRLLMKVKATCPPVDQKYLPADAIPQMLEEQVVKHDPDGVCSEAFKKSLKGFLEGQKNELKRVMQLVSNSAQKSEILEDVSHKICGITDRQLEVFIRICIGRYRSKVIEAGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNITQGVPRIKEIINAAKKISTPIITAELEFDSNVNVARMVKGRIEKTVLGQVAKSIKIVMTSRLASVVISLDMERIQDAQLHIDANVVKESILQTPKLKLKEQHVKVLDVKKLEVVPPADRSRIHFELHSLKNLLPLVVVKGIKTVERVVIAEKKKDNKSQNKEAKKLYQLFVEGMGLQTVMGVEGIDGRKTMSNHVMEMLQILGIEAARSCIINEIAATMASHGMSIDIRHMMLLGDVMTFRGEVLGITRFGIQKMDKSILMLASFEKTGDHLFNASVNGRDDKIEGVTECIIMGIPMQLGTGILKVMQRVDPLPLLQYGADPVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QL72</accession>
    <name>A0A0D2QL72_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDSL esterase/lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G007700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QL72"/>
    <dbReference type="STRING" id="29730.A0A0D2QL72"/>
    <dbReference type="Gramene" id="KJB17611">
        <property type="protein sequence ID" value="KJB17611"/>
        <property type="gene ID" value="B456_003G007700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050592">
        <property type="entry name" value="GDSL_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642">
        <property type="entry name" value="GDSL ESTERASE/LIPASE EXL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45642:SF95">
        <property type="entry name" value="GDSL-LIKE LIPASE_ACYLHYDROLASE FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB17611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9879" checksum="C1582B8A5B99AB20" modified="2015-04-29" version="1">MSGQLELFKECIKKIKGAVGEERAATIISKAIYIVCTGSNDISSTYFSTPFRRPHYDINGYAEFNARYANQFLQDLYGLGARRIGLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLA3</accession>
    <name>A0A0D2QLA3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G153600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLA3"/>
    <dbReference type="Gramene" id="KJB20539">
        <property type="protein sequence ID" value="KJB20539"/>
        <property type="gene ID" value="B456_003G153600"/>
    </dbReference>
    <dbReference type="OMA" id="NSSRFPQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB20539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="11555" checksum="D69D16B45327B0C6" modified="2015-04-29" version="1">MLLEISVDQKQLASIIFSFPITDLAINSSRFPQIFLPFATPSNSHLFALNLNILDSSSPLLVGRYSESPQPGNVLLPSLKLLLQPNGQKYYQFSEYNKNKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRK4</accession>
    <name>A0A0D2QRK4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G317000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_009G317000"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1485">
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010486">
        <property type="term" value="F:manganese:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
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        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
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        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF5">
        <property type="entry name" value="METAL TOLERANCE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="113"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="10">
        <location>
            <begin position="324"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB60647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="400" mass="45446" checksum="8160385CFEF34496" modified="2015-04-29" version="1">MVRGEMVEMVARETDEELSLLPHQSNVDRSWRLNFDGFQLSPEHKDKKPPRSLHDCLGVLGPEDNVAEYYQQQVEMLEGFSEMDALAERGFIPGMSKEERERLARSETLAIRISNIANMVLFAAKVYASMRSGSLAIIATTLDSLLDLLSGFILWFTAFSMSTPNPYQYPIGKKRMQPLGILVFASVMATLGLQIILESVRTMVSNEDEFNLTNEQERWVVGIMLGVTLTKLLLMFYCRTFTNEIVKAYAQDHFFDVITNIIGLVAVLLANYIDDWMDPVGAIILALYTIRTWSMTVLENVNSLVGRSAAPEYLQKLTYLCWNHHKAIKNIDTVRAYTFGSHYFVEVDIVLPANMALQEAHDIGESLQEKLELLPDIERAFVHLDYEFSHKPEHAQAHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2K3</accession>
    <name>A0A0D2R2K3_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">RIN4 pathogenic type III effector avirulence factor Avr cleavage site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G310200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_007G310200"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF87">
        <property type="entry name" value="OS09G0253000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB45528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="117" mass="12970" checksum="C81F9CE258B658AF" modified="2015-04-29" version="1">MSDQGRPLPKFGEWDVNDPASADGFTVIFNKARDEKKTGGKPESLEKADTHGKPGADPNKPQSVKKMALLRSSPAGGILKNSCRYKSFHCMMKPPPYILNKIGMNGGHLIKLFWDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4V8</accession>
    <name>A0A0D2R4V8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G360700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4V8"/>
    <dbReference type="STRING" id="29730.A0A0D2R4V8"/>
    <dbReference type="Gramene" id="KJB46328">
        <property type="protein sequence ID" value="KJB46328"/>
        <property type="gene ID" value="B456_007G360700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761652"/>
    <dbReference type="eggNOG" id="KOG1248">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48412">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48412:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="3">
        <location>
            <begin position="367"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1082"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1159"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB46328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1179" mass="129400" checksum="FF6583CDDC7B76BB" modified="2015-04-29" version="1">MKKKQTPNSPLDDKETPKEFDNENEIPLKDGSDICQQLMDRYSKSSAPQHRHLIATAAAMRSILSSESLPLSPPAYFAASISALDDDSAATLDSTAIGALLTFLSLVVPAVPKGGIASGKAKEAVEVVVTVLGKEGLGVASLRSGVKCLGLLLVGFSDLQDWHSVQFGLESLLGFAIDKRPKVRRCAQEYLEKFFKSFQSSDVMKEASKLVLSLLKRHMRVALTLNTIKSADDSKDETLSNPEHLEVLHMLNVLKLTVPYLSATIRLKILSELCKLTSSEFSILTRNIHKTIEVFFGSSNAEAIIPVTENIIVSLSSYVSGEKNPVDTLISAATLLKCAVDKLYAVDSNSWTKHTPLVCDSLAALLSSEASVASHASDIMKELISHHIDLKSLSSDNNGLGSEEADAIKSICSIFENTLSSSDGIPNEHVLAVLTVLFQKLGESSYIFMKGIVHKLADLMNRTSGNTSNTNHLQNCVGSVVTVIGPERMLTLLPITLAVDNLMHSNMWLVPILKDYVVGASLSYYMEHIVPLAKSFQQASCKVKKSVIRQDLQAHGHSLWGLLPAFCHYPIDTHKRFKALAALLIDILKEDSLMHENIAFAIQILVNQNKNILRSGEDADESNNTVMGDSKLELRIPATYSKKTATKNIKALSSCAPEILQALTDVFIHSIPAKRLYLKDAIGCLASITDFSITKRIFVSLVEKLQSIDGEGEFVKQAGNADEVVEKEKNINTMGKDASRCIIMELASSLISGAEEDLIDFIYVLIKQTFQETNEIGHHEAYYALSRILEEHAWFCSSKSEELIDLLLGLKSPANIPSLRNRLDCFNTLMVHTLKVSSLEENTKPFLILNEIIVTLKDGKEETRKTTYDILLKMSSTLRKSSDLESDPPYHKLISMIMGYLSGSSPHIKSGAVAALSVLVYDDPEICISVPDLVSSILSLLQTKAVEVIKAVLGFVKVLVSTLQAKDLQNFLSDIINGVLKWSSISRNHFRSKVTIILEILTRKCGIAAVQSVAPEKHKGFLNTVIENRRGKTTSEETDVNDADKVPVGSSTEGSRKRRDKGFGAFKSKNDMIEHRKRKRDKRDGGSKHAESSEHVGHGGGMKMAKRAKHFGKPMNGHSEGNGKKKNFDKGSSTGRGQKRKINQATTSQKGVAAGDKRHSFKVQTRPKKFRGVNKKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R815</accession>
    <name>A0A0D2R815_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_010G142500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R815"/>
    <dbReference type="STRING" id="29730.A0A0D2R815"/>
    <dbReference type="Gramene" id="KJB66521">
        <property type="protein sequence ID" value="KJB66521"/>
        <property type="gene ID" value="B456_010G142500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66522">
        <property type="protein sequence ID" value="KJB66522"/>
        <property type="gene ID" value="B456_010G142500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66523">
        <property type="protein sequence ID" value="KJB66523"/>
        <property type="gene ID" value="B456_010G142500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66525">
        <property type="protein sequence ID" value="KJB66525"/>
        <property type="gene ID" value="B456_010G142500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66527">
        <property type="protein sequence ID" value="KJB66527"/>
        <property type="gene ID" value="B456_010G142500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774011"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NERHYHI"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347:SF2">
        <property type="entry name" value="OS02G0132300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46347">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="5">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB66522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="254" mass="29304" checksum="E384BB4EF64EFD37" modified="2015-04-29" version="1">MQLVSNDSRKEDISEREPILCQPDISQTSEECEIAAVGGDCIVVSEDLEEINVDETSHLVNADHPQCRICLDNEGDDLIAPCHCRGTQKYVHRSCLDNWRSTKEGFAFAHCTECRALFILRANVPPDRWWLRLKFQFLVARDHAFIFVIVQLIVAFLGVLVYKFYGEELREMFGYDEHPYGFYTMAVLAIVLVGLLYGFFIAIICGQRINERHYHVLAKQELTKEYVVEDREDNKNTPELDPSHVTELRILGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R847</accession>
    <name>A0A0D2R847_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G022300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R847"/>
    <dbReference type="STRING" id="29730.A0A0D2R847"/>
    <dbReference type="Gramene" id="KJB28019">
        <property type="protein sequence ID" value="KJB28019"/>
        <property type="gene ID" value="B456_005G022300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796438"/>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CDLDNMR"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB28019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="215" mass="24100" checksum="7F187E51A7D7569B" modified="2015-04-29" version="1">MSDDETVEEYLFKIVIIGDSAVGKSNLLSRFARNEFNAHSKATIGVEFQTQSVEIDGKEVKAQIWDTAGQERFRAVTSAYYRGAFGALLVYDISRRATFDNVARWLDELNSHSDTTVAKMLVGNKCDLENTREVSLDEGKSLAESEGLFFIETSALDSTNVWTAFEIVIREIYNNVSRKVLSSDSYKARLSVNRVSLVNDDELKQSKTKYACCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAL5</accession>
    <name>A0A0D2RAL5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G063500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAL5"/>
    <dbReference type="STRING" id="29730.A0A0D2RAL5"/>
    <dbReference type="Gramene" id="KJB48323">
        <property type="protein sequence ID" value="KJB48323"/>
        <property type="gene ID" value="B456_008G063500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQB0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTHILVR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36409:SF1">
        <property type="entry name" value="BLOC-1-RELATED COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36409">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB48323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="15606" checksum="0019B304930F7DEF" modified="2015-04-29" version="1">MGASESSLAAYSLSSTDQISTISQRSETVDPVLEKLKSLRITSPILTTPPTDGSLTDILVRRPSSSSSQVAVNPKVFLELLSVYRDWQEEKAQTICKKQEDIEYKIEVADALATSPKFKPLSFPNEDCFTTFSRSLGSLKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF00</accession>
    <name>A0A0D2RF00_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G142200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF00"/>
    <dbReference type="STRING" id="29730.A0A0D2RF00"/>
    <dbReference type="Gramene" id="KJB30414">
        <property type="protein sequence ID" value="KJB30414"/>
        <property type="gene ID" value="B456_005G142200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794205"/>
    <dbReference type="eggNOG" id="ENOG502QPUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.760:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015212634" description="Expansin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="8">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="9">
        <location>
            <begin position="167"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB30414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="250" mass="26829" checksum="43E4BD3818E5EDF2" modified="2015-04-29" version="1">MKMAFAKVFLLGFLAMVFGVQGYGGGWTNAHATFYGGSDASGTMGGACGYGNLYSQGYGTNTAALSTALFNNGLSCGSCYEIKCMDDGKWCLPGSIVVTATNFCPPNNALPNNAGGWCNPPLQHFDLSQPVFQHIAQYRAGIVPVAYRRLPCRRKGGIRFTINGHSYFNLVLITNVGGAGDVHAVAIKGSRTGWQPMSRNWGQNWQSNTYLNGQSLSFKVTTSDGRTVVSNNVAPAGWSFGQTFTGRQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFF1</accession>
    <name>A0A0D2RFF1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FRIGIDA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G042900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Frigida family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFF1"/>
    <dbReference type="STRING" id="29730.A0A0D2RFF1"/>
    <dbReference type="Gramene" id="KJB28346">
        <property type="protein sequence ID" value="KJB28346"/>
        <property type="gene ID" value="B456_005G042900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTAYAMS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000009">
        <property type="entry name" value="uncharacterized protein LOC106777373 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012474">
        <property type="entry name" value="Frigida"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_uL18_bac/plant/anim"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31791:SF2">
        <property type="entry name" value="FRIGIDA-LIKE PROTEIN 4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07899">
        <property type="entry name" value="Frigida"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4 8" id="KW-0221">Differentiation</keyword>
    <keyword evidence="6 8" id="KW-0287">Flowering</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="644"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB28346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="830" mass="92447" checksum="DE27C29474098FCE" modified="2015-04-29" version="1">MGSVPNPGELTELTQPSFDEFQHQTSLMTGCTLMWKELSDHISSLEANLMRQSEALKRKIEALDSETKTSLDSLKKRELSIDDSVKIAVNRVELLKKDALKTLNDDNPDGEVDNGDGLLQILKSTCLRMEAKEFWNFVSGRKKDIELLREKIPEALSECIDPAKFVMEAISEVFPVDKRGNERGNDLGWACVLVLESLIPAVVDPVIGKSRMLITRSVKEKAKEIAETWKRSLEERGGIDNVKTPDVHTFFQHLITFGIVNEEELDLYRKLVIGSAWRKQMPKLAVSLGLGDKMPDMIEELISKGQQLDAVHFTYEVGLVNRFPPVPLLKAFLKDAKKAASSILEDPNNAGRAAQLAARKEQSALRAVMKCIEEYKLEAEFPPENLKKRLEQLEKTKTEKRKPAAVPANKRTRASNGGPMPPAKAGRSTNAYVSSFAAPPSIVRSPSHPQYPAAVPAYPSPPPAMYGTQTPPTCPYMYSPEAAPQLAGSYPGAPMNYPAYGGYGNGIAPAYQLRSFSSVFPPVINKEDTKPTNYSSKIYLSPLFNDCSFKLGSNGIELVDDETWRVSSGLAHAYKGFDGEMETLPSMEAVDQRVDNGSPISEDDQDFDDIDNMRIRGNLFYKIDRGSKEFEEYAYDFHRKKGPKNKDDRKESKNKESLHKKDDPKESKRLEKSNVKLLKDVKNGSVRNIPDKVEVCSAEKKVRTPTFNQLTGPYHEPFCLDIYISKASVRACIIHRATSKVVAVAHSISKDMKFDLGSTRNASACAAVGLILAQRALDDDIHDVIYTPRKGDRLEGKLQIVLQSIIDNGVNVKVKLKQRRPKKAVQVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFN0</accession>
    <name>A0A0D2RFN0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_003G027400</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFN0"/>
    <dbReference type="Gramene" id="KJB17980">
        <property type="protein sequence ID" value="KJB17980"/>
        <property type="gene ID" value="B456_003G027400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMISMIN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000013">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000252">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF59">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250506" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="18"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="400"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB17980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="750" mass="84730" checksum="EB11594B61849BB3" modified="2015-04-29" version="1">MENLIIIFLFFLPFSSAYTRPNEHFINCGSDFNFTGNDDRNFVAIVLRVHNQNKRHLLSSGFELLSNFSVKNSPAGSPVIKEFLVNIDEGRFKINFIPSQGSNIAFVNAIEVFLAPESFVPDTAPLAGRRRGSFDGLRSRVLHTVYRINVGGATITTDEDTLWRNWIPDDQFLSDPTSAKNSSFFSGEPAYTSGRANEYTAPSLVYKTAKELNVEDNTSRQFFNITWSFNVSKSSRHFVRFHFNDIVSSSIDSVKFDLYIYDKFDKLVYPYNETGQLEVPFYFDFVVDSDKSGVMNVSVGPRNDSENQMAFLNGIEIMEFMKESSFVVPEERSKKRTNLVPIVGSVVGAVVFVVGFIVAMVMFLKCRKRKPLSEKTSNMSPLDLALRISYYEIEQATKNFDSGLLIGEGGFGRVYEGLFRGKKVAVKRSEPGHGQGLLEFQTEIVVLSRIRHRHLVSLIGYCDERSEMILVYEFMEKGTLRDHLYNRSSDVEKPYFARSDLSWKQRLEICIGAAKGLNYLHTGSDGGIIHRDVKSTNILLDERLVAKVADFGVSKFNLPDAEHSVDVKGTLGYLDPEYFLSLQLTDKSDVYSFGVVLLEVLCARPAVMASNRREEVNLAEWGMLWLRKGQLEKIIDPMLVDTINPNSLRKFVETTEKCLRPSGNERPMMRDVLWDLEYALQLQLIPMNNGTFDDSTTNASLEFSMMPVLHRLPSNSFPAVEEEDATVLSVDAFDVTASDVFSLLSVGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RME4</accession>
    <name>A0A0D2RME4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine gamma-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_008G258500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RME4"/>
    <dbReference type="STRING" id="29730.A0A0D2RME4"/>
    <dbReference type="Gramene" id="KJB52368">
        <property type="protein sequence ID" value="KJB52368"/>
        <property type="gene ID" value="B456_008G258500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765340"/>
    <dbReference type="eggNOG" id="KOG0053">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGGMITF"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000046">
        <property type="entry name" value="Cystathionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000087">
        <property type="entry name" value="Putative methionine gamma-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF80">
        <property type="entry name" value="CYSTATHIONINE GAMMA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB52368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="49016" checksum="348546172D0D6BE1" modified="2015-04-29" version="1">MAETQSRGLVFAGKKRGTGTDDFDGDDIFVAKKSMLPTMATESDPAAALANARHEFGEHGGVNMSIEASATFTVMEPETMRRMFAGELGPDRDFFIYSRHFNPTVLNLGRLMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHVVASRTLYGGTHALLTHFFPRACNITTTFVDIGDLEAVKNAIVEGKTKVLYFESMSNPTLTVANIPALSRIGHEKGTTVVVDNTFAPMVLSPARLGADVVLHSISKFISGGADVIAGAVCGPASLVNSMMDLHQGALMLLGPTMNAKVAFELSERIPHLGLRMKEHCRRAMEYAIRMKKLGLKVIYPGLEDHPQHELLKSMANKEYGYGGLLCVDMETEERANRLMHHLQNYTQFGFMAVSLGYYETLMSCSGSSTSSEMNAEEKELAGISPGLVRMSIGYIGTLEQKWSQLEKALSRMQDGTLLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNY8</accession>
    <name>A0A0D2RNY8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_011G175500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNY8"/>
    <dbReference type="SMR" id="A0A0D2RNY8"/>
    <dbReference type="STRING" id="29730.A0A0D2RNY8"/>
    <dbReference type="Gramene" id="KJB72392">
        <property type="protein sequence ID" value="KJB72392"/>
        <property type="gene ID" value="B456_011G175500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777155"/>
    <dbReference type="eggNOG" id="KOG1164">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THHNGRT"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000164">
        <property type="entry name" value="Casein kinase 1-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="298"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB72392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="463" mass="52588" checksum="BED84E0F3C1129C7" modified="2015-04-29" version="1">MEHVIGGKFKLGRKIGSGSFGELYLGVNVQSGEEVAVKLESIKTKHPQLLYESKLYMLLQGGTGIPHLKWFGVEGEYNVMVIDLLGPSLEDLFNYCNRKFSLKTVLMLADQLLIRVEYMHSRGFLHRDIKPDNFLMGLGRKANQVYIIDYGLAKKYRDLQTHKHIPYRENKNLTGTARYASVNTHLGVEQSRRDDLESLGYVLMYFLRGSLPWQGLKAGTKKQKYDKISEKKMLTPIEVLCKSYPSEFTSYFHYCRSLRFEDKPDYSYLKRLFRDLFIREGYQFDYVFDWTIRRYPQVGSSSRARPSPKPGLNPPGVSAERTERPSVGQEIGERVSGTIEPLTRRIGSGQGLHGDQSRYRSDDVPSSKDVQPDSEKVRSSSRNDSSSKRPVATGSRLDSSGEPNENRSSRLVSSSSRLSTTQRILPGFQSRSASYTRTSATRGGQDDTLRSFEFLTIGSGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSZ6</accession>
    <name>A0A0D2RSZ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Geranylgeranyl transferase type-1 subunit beta</fullName>
            <ecNumber evidence="4">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Geranylgeranyl transferase type I subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G256900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.59" evidence="4"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSZ6"/>
    <dbReference type="SMR" id="A0A0D2RSZ6"/>
    <dbReference type="STRING" id="29730.A0A0D2RSZ6"/>
    <dbReference type="Gramene" id="KJB73862">
        <property type="protein sequence ID" value="KJB73862"/>
        <property type="gene ID" value="B456_011G256900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0367">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWCLMRQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02895">
        <property type="entry name" value="GGTase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000021">
        <property type="entry name" value="Geranylgeranyl transferase type-1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041960">
        <property type="entry name" value="GGTase_I_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF4">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-1 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="14">
        <location>
            <begin position="35"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB73862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="380" mass="42638" checksum="6C451BBBB4F1879B" modified="2015-04-29" version="1">MATREWNPLDFDIGEEEDEEGTPSPSSISPPLQYFDRDRHVAFLEMMYNLMPHHYQSQEINRLTLAFFTISGLHLLRALDRVDKDRVADWVLSFQAHPRSRAELKIGQFYGFHGSRTSQFPPDENGVSARNAGHLASTYCALAILKTVGFNLLTIDKESILISLRNLQQPDGRYASTFMPVDVGAETDLRFVYCAAAICFMLEDWSGMDREKAKEYILKCQSYDGGFGLMPGLESHGGGTYCAVASLRLMGYIEDDLLSKTVTSSIINVPLLLDWCMQRQAIDGGFQGRANKPSDTCYAFWIGAVLRILGGYKFIDKIALHRFLLTCQSEFGGFSKYPRDLPDIYHAYYGYTAFSLLEEPGLNPLCAELGMTDLTAIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RXL3</accession>
    <name>A0A0D2RXL3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G166500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2RXL3"/>
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        <property type="protein sequence ID" value="KJB36599"/>
        <property type="gene ID" value="B456_006G166500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37215">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37215:SF1">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB36599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16919" checksum="185DF9283A516A0A" modified="2015-04-29" version="1">MVGRERRIFVGLAVAMFLGITVYFRLWMIDYSVSSHDTELLRRQFDLANKEAMDESAEWRLRFDEEADKASKCAKELEKIKESIVKKEDSISFNNKLALLQKKWTSGLKGCFIYATYENAALLERVETLKNKLEDEKMRCRHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RZ15</accession>
    <name>A0A0D2RZ15_GOSRA</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">B456_004G137200</name>
        <name evidence="3" type="ORF">Gorai_014719</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RZ15"/>
    <dbReference type="STRING" id="29730.A0A0D2RZ15"/>
    <dbReference type="Gramene" id="KJB24290">
        <property type="protein sequence ID" value="KJB24290"/>
        <property type="gene ID" value="B456_004G137200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791384"/>
    <dbReference type="eggNOG" id="ENOG502RYMX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRAPFIN"/>
    <dbReference type="OrthoDB" id="613853at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22160">
        <property type="entry name" value="F-box_AtFBL13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053772">
        <property type="entry name" value="At1g61320/At1g61330-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053781">
        <property type="entry name" value="F-box_AtFBL13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055357">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145:SF68">
        <property type="entry name" value="FBD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34145">
        <property type="entry name" value="OS02G0105600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23622">
        <property type="entry name" value="LRR_At1g61320_AtMIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB24290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0583878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="444" mass="51091" checksum="E9B7DC6604763D21" modified="2015-04-29" version="1">MSEVLQITSPSVSKAQKREYDNINELPDEVLISILARMPMKEAARTSVLSRRWKKLWTSHPYLVFDGSNSLRGIHYRSEQVLESEQFKYLNWVNDVLESHHDAAIDEFKIRFYLDQCYQSDIDDWVRFAFGKKVQRFELDLSSSRVISHVQDSGYELCSHTLHFQTPLSLTSLVLKQVRVSGEVLENLLSNSPFLERLCIGASTSLVHLRLAGPSLCLTYLEITACARMKSLELDAPNLLSLKYSGQNIEIRFIEVPNLAEVFIGGMFVETCTRNYFLPLVPTFASQLQKLVLEMRVDERKMKLFEYPILSQLKELELQVRARDHDSLLCLTSLINASPSLNQLSLELSWSKSYTRRRVMKVKRHHYNLKEVEIRGFVGGMVDSEFCIYLVKNAIMLEKMSIDPFTKNEKGGGNCFKAERARAARVRAEDLRSKYGVEDKLVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S0V5</accession>
    <name>A0A0D2S0V5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G104200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S0V5"/>
    <dbReference type="Gramene" id="KJB76737">
        <property type="protein sequence ID" value="KJB76737"/>
        <property type="gene ID" value="B456_012G104200"/>
    </dbReference>
    <dbReference type="OMA" id="CFAGHCH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266952" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB76737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8827" checksum="C247752392D1B460" modified="2015-04-29" version="1">MQWYSVFILFFLHFLSIQTIIRTTKSTHRNVVLHIINSFQDDSGRRCRFAGHCHKTKRKYTEKKLSINRETEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2A7</accession>
    <name>A0A0D2S2A7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ALOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G162300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant homeotic and developmental regulators ALOG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2A7"/>
    <dbReference type="STRING" id="29730.A0A0D2S2A7"/>
    <dbReference type="Gramene" id="KJB57403">
        <property type="protein sequence ID" value="KJB57403"/>
        <property type="gene ID" value="B456_009G162300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771089"/>
    <dbReference type="eggNOG" id="ENOG502QTCS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEFTIMS"/>
    <dbReference type="OrthoDB" id="1906822at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009299">
        <property type="term" value="P:mRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009416">
        <property type="term" value="P:response to light stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040222">
        <property type="entry name" value="ALOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006936">
        <property type="entry name" value="ALOG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31165">
        <property type="entry name" value="PROTEIN G1-LIKE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31165:SF111">
        <property type="entry name" value="PROTEIN LIGHT-DEPENDENT SHORT HYPOCOTYLS 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04852">
        <property type="entry name" value="ALOG_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51697">
        <property type="entry name" value="ALOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ALOG" evidence="9">
        <location>
            <begin position="54"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB57403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="208" mass="23435" checksum="E61B9597870FE637" modified="2015-04-29" version="1">MILSCQKYPIIPLGEKRLVEFTIMSGDIARDSAEGSSRSSVSHHNQPQSPPLSRYESQKRRDWNTFGQYLKNQRPPVALSQCNCNHVLEFLRYLDQFGKTKVHLHGCVFFGQPDPPAPCTCPLRQAWGSLDALIGRLRAAYDEHGGSPETNPFGNGAIRVYLREVRDCQAKARGIPYRKKKKKKTQIKPKVDDPMPSSNQQPSSQLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2G0</accession>
    <name>A0A0D2S2G0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_006G130700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the trafficking of vacuolar proteins. May function as a sorting receptor for protein trafficking to the protein storage vacuole (PSV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endomembrane system</location>
            <topology evidence="14">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Protein storage vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2G0"/>
    <dbReference type="STRING" id="29730.A0A0D2S2G0"/>
    <dbReference type="Gramene" id="KJB35856">
        <property type="protein sequence ID" value="KJB35856"/>
        <property type="gene ID" value="B456_006G130700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799427"/>
    <dbReference type="eggNOG" id="KOG4628">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYTIFTV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032586">
        <property type="term" value="C:protein storage vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02123">
        <property type="entry name" value="PA_C_RZF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000276">
        <property type="entry name" value="Receptor homology region transmembrane domain-and RING domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000020">
        <property type="entry name" value="Receptor homology region transmembrane domain-and RING domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044744">
        <property type="entry name" value="ZNRF4/RNF13/RNF167_PA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00060484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="448" mass="48599" checksum="E658B24AE94363FE" modified="2015-04-29" version="1">MKMNRVVVLLLLSWFLCFSSVFWMTSASVVLIGNNVTLSFDDIEANFAPAIKGSGECGVLYLANPLDACSDLSIKVDELSNGSSPFALVIRGGCSFEEKVRRVQKAGFEAAIVYDNDDDGVLVAMAGNAAGIKIHAVFVSKASGEILKKFAGSTDMELWLIPSFENSAWSIMAISFISLLAMSAVLATCFFVRRHRIRRELPQSSRVREFHGMSRRLVKAMPSLIFTAVLEDNCTSITCAICLEDYTVGEKLRILPCRHKFHAFCVDSWLTTWRTFCPVCKRDARTSTGDPPASESTPLLSSTLSTMSSSALSSVRSSLASSSAIQIAPAVSRSPSVAHTHSLASNPYIQQSLRSYRQSPMSFSRSSVDLRNASSQRSRASHLVSPASLNYPSISPLNARYISPYFPSPSNASPSIVSSSGHPLHPLHYSESAASFSPFASAQSLPDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3Y3</accession>
    <name>A0A0D2S3Y3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidylinositol 4-phosphate 5-kinase</fullName>
            <ecNumber evidence="6">2.7.1.68</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G161300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="6"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3Y3"/>
    <dbReference type="STRING" id="29730.A0A0D2S3Y3"/>
    <dbReference type="Gramene" id="KJB77857">
        <property type="protein sequence ID" value="KJB77857"/>
        <property type="gene ID" value="B456_012G161300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17302">
        <property type="entry name" value="PIPKc_AtPIP5K_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017163">
        <property type="entry name" value="PIno-4-P-5_kinase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF25">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037274">
        <property type="entry name" value="PIP5K_plant_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="8">
        <location>
            <begin position="396"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB77857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="819" mass="93090" checksum="910FD80FBB326E51" modified="2015-04-29" version="1">MRSLKQTMNNSVLHHASMWRVLKGIYILFGTRSCVLRLCFVRLKSKLFCSCRLNEKAFPNGDLYVGDFKEILPHGKGKYTWSDGTVYDGDWEAGKMSGKGLLIWPSGAKYNGDISGGYLHGFGAFTASDGSIYEGHWRMNIRHGYGKKKYSNSDIYEGEWKEGEHEGKGIYFWNNGNKYTGNWKRGKMHGRGVMEWINGDHYNGCWFNGFRHGNGIYQYADGGYYFGTWTRGLKDGKGLFYPAGSKRPSLKKCCTSLGYDNDHKTALPQCSSLHLEEHIVKKPSIKRSLSEKILVSGVLKGSGRMSSKTAESSGLSDSGREFVHHNSSGTFSFDSDAGQSELQENTAVIYEREYMQGVMIKERIRDYNKLSKKAEKKTKFHAKETQKSSCVGIFKGHNSYHLMLNLQLGIRYTVGKITPVPKREVRAADFGDRARITMFFPKKGSQFTPPHKSIDFYWKDYCPMVFRHLRELFKLDAAEYMMSICGDDGLTEISSPGKSGSLFYLSHDDKFVIKTLKKSELKVLLKMLPKYHNHVKEHENTLITKFFGLHRITLPGKRKVRFVVMGNMFCTELRIHRRYDLKGSTHGRITDKDKIHENTTLKDLDLSYEFHMDKSLREFLFDQIADDCAFLKSQQIIDYSLLLGLHFRAPEPLDGLVEPPNISPNMQSSPAGQDGEVLFPSKGFVLLAHEPSSVNTDPGPHIRGRALRAFSLGNQEVDILVPGTGRLRVQLGVNMPARANHKLPQDESDSAEVELFEVYDVILYMGIIDILQEYNAKKKAEHAYKSVKFGPTTISVVEPELYANRFTNFLKQKVFPEQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S422</accession>
    <name>A0A0D2S422_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanobacterial aminoacyl-tRNA synthetase CAAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G113600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S422"/>
    <dbReference type="STRING" id="29730.A0A0D2S422"/>
    <dbReference type="Gramene" id="KJB39084">
        <property type="protein sequence ID" value="KJB39084"/>
        <property type="gene ID" value="B456_007G113600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802854"/>
    <dbReference type="eggNOG" id="ENOG502QWJR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NVMGMAT"/>
    <dbReference type="OrthoDB" id="2014299at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025564">
        <property type="entry name" value="CAAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033344">
        <property type="entry name" value="CURT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33222:SF9">
        <property type="entry name" value="PROTEIN CURVATURE THYLAKOID 1B, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14159">
        <property type="entry name" value="CAAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanobacterial aminoacyl-tRNA synthetase CAAD" evidence="4">
        <location>
            <begin position="93"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB39084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="178" mass="19179" checksum="E9E400775C229F1A" modified="2015-04-29" version="1">MASASSNSLSISPSSTLVDAKAPRQPTAASPQCVTLPTLPPPPVQSQSRPWKTTAYCRKIARNVMAMATGETLATREAPTEVTPTELTEFINKIQETWDKVEDKYAVSSLAVAGLVLVWGTAGMVSAIDKLPVISTFLEVVGIGYTGWFAYKNLIFKPDRAALISKIKDTYKEILGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7N7</accession>
    <name>A0A0D2S7N7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G059100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7N7"/>
    <dbReference type="STRING" id="29730.A0A0D2S7N7"/>
    <dbReference type="Gramene" id="KJB40339">
        <property type="protein sequence ID" value="KJB40339"/>
        <property type="gene ID" value="B456_007G059100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S24B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CVLWVQG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045847">
        <property type="entry name" value="AIG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844:SF17">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB40339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="210" mass="24069" checksum="403487FD0D2095AD" modified="2015-04-29" version="1">MVRLKQLEQDIQQHLRRYRASISTIDFSFKSLKKVTKPKAEANIANALKHKTAERHRRKRISRQFDMLRTILPNLIKMDKASVLGETVRQVRELKNRVKEMKGASDGSLECVLPGELNSLSFGFSEKDGNLVKATFSCDDRPELIADLTREIRKVSGTVVRAEMVFIGGRNKSVLWIKGFSGNERMGMLKRALKMAIDIPKKNWNPRFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S849</accession>
    <name>A0A0D2S849_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G066000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S849"/>
    <dbReference type="STRING" id="29730.A0A0D2S849"/>
    <dbReference type="Gramene" id="KJB40479">
        <property type="protein sequence ID" value="KJB40479"/>
        <property type="gene ID" value="B456_007G066000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802331"/>
    <dbReference type="eggNOG" id="ENOG502QQH0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYDWKLC"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000084">
        <property type="entry name" value="probable methyltransferase PMT23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004159">
        <property type="entry name" value="Put_SAM_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108:SF1130">
        <property type="entry name" value="METHYLTRANSFERASE PMT26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10108">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03141">
        <property type="entry name" value="Methyltransf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="115"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB40479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="899" mass="101392" checksum="3CF4668512ABF45A" modified="2015-04-29" version="1">MALGRYNRVDNNNNKSSSYCSTVTIVIFMGLCLVGIWMITSSWVVPVQNGDDPAEEKKNQLKDQVETVIVDSNDRDNKPQFEDKPNDLRKDGPEKNLDVSLAKDKGKANLAAEENQEKTEEAKWDKSKKDNQQFNSVGGEKNVYNSENLGGQGSENNNEKPHSIKDDKKSGSDYAEKKGDESTSRTYGDKVDKNDDKVSDKRSADQVKGKSSNEDSPKGDKVFDKSFVDQVKKSSNEVFPKGDKVDKNNDNGFDKSSDSQVKKSSNEDAPKGDKVFDKSFDDQVKKRSNEVFPKGDKVDKNNGNVFDKSSDSQVKKSSNEVFPSVAQSELLNETMIQNGSFTTQAAESNKEKNAESSSNSSSKDYSWKLCNSTAGPDFIPCLDNCEAIRNLPTNIHYEHRERHCPEVPPTCLVPLPEGYKFPIEWPKSRDKIWYKNVPHSKLVEFKGGQNWLKITGDYLTFPGGGTQFRRGALHYIDFIQKAVPDIAWGKRSRVILDVGCGVASFGGYLFERNVLAMSLAPKDEHEAQVQFALERGIPAVSAVMGTKRLPYPGTVFDIIHCARCRVPWHIEGGKLLLELNRLLRPGGFFLWSATPVYQLKAQDVEIWKAMIEQTKAMCWELVNKTSKEPINKVAIATFRKPTSNECYEQRSQQEPPLCPESDDPNAAWNVPLQTCMHKVPLDPSERGSKWPEEWPARLEKSPYWLLSSQVGVYGKAAPEDLAADNEHWKQVVTKSYMQGMGINWSSVRNVMDMKAVYGGFAAALKDMNLWVMNVIPVDSPDTLPIIYERGLFGIYHDWCESFSTYPRSYDLLHADHIFSRVKKRCNFVAVVAEVDRILRPGGKLIARDDVETITELENMVRSMHWEVRLSYSKDKEGLLCVQKSMWRPTEVETLTYAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDX0</accession>
    <name>A0A0D2SDX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G098800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-7 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDX0"/>
    <dbReference type="STRING" id="29730.A0A0D2SDX0"/>
    <dbReference type="Gramene" id="KJB29410">
        <property type="protein sequence ID" value="KJB29410"/>
        <property type="gene ID" value="B456_005G098800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043515">
        <property type="term" value="F:kinetochore binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140694">
        <property type="term" value="P:membraneless organelle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042327">
        <property type="term" value="P:positive regulation of phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033044">
        <property type="term" value="P:regulation of chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000026">
        <property type="entry name" value="Centromere-associated protein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF36">
        <property type="entry name" value="KINESIN HEAVY CHAIN ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 7 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="633"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="299"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="355"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB29410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="658" mass="74960" checksum="80F6A9033E490521" modified="2015-04-29" version="1">MIYNFIYVLGTAFAYGQTSSGKTFTMNGSSNDPGIIHRAVNDIFQKINMISDREFLIRVSYMEIYNEEINDLFAVENQKLQIHENLERGIFVAGLREEIVNNAEQVMKLLESGEVNRHFGETNMNARSSRSHTIFRVVIESKGKDTGSFGDYSSSDAIRVSVLNLVDLAGSERIAKTGTGGVRLKEGKYINKSLMVLGNVINKLSDSAKRRAHIPYRDSKLTRILQPALGGNAKTSIICTVAPEEIHIEETKGTLLFASRAKRVTNCAQVNEVLTDAALLKRQKLEIEELRWKLQGSHAEVLEQEILKLRNDMLKYELEREKLEMELEKERRSHKERDQYIRDQLMMIENLSSLVSDGDGSSSQGSMKESPTEECHNRGDDFKTPCFKAAPKAFVAKRSNYSQLPDFSPLPDSFSDVADEDTWFKINKGYIADLDSLQTTPARKVQSFPPEDVTPNYLNKKYKKELQNLKRRLELVTEEKNELQRKLAEDIEVKDRLKGYISKLKQEALLAREMPQRLCGSVTSFKDTYEEVLSKMQRYTFDGKSSTAKLLRCISEIGSILFSTMETSISNTTDRHKLSSENDSLIQEYNKMLSEKLKSTITSLILSETASSEDKQTKTPCSCNFEVVAWSRYHVSILVLFFVMILGYFVPFFRTLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SG04</accession>
    <name>A0A0D2SG04_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G399500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SG04"/>
    <dbReference type="Gramene" id="KJB62068">
        <property type="protein sequence ID" value="KJB62068"/>
        <property type="gene ID" value="B456_009G399500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9411" checksum="D8CD1968985CB8C4" modified="2015-04-29" version="1">MIQAEFFTILITNVCNLLKSSHHIRRLLCSSNLGINSCCDYDTINLPKIFMIALISDNKELSFYFFWKKEMSLILLVCFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SG73</accession>
    <name>A0A0D2SG73_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G190400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SG73"/>
    <dbReference type="STRING" id="29730.A0A0D2SG73"/>
    <dbReference type="Gramene" id="KJB43254">
        <property type="protein sequence ID" value="KJB43254"/>
        <property type="gene ID" value="B456_007G190400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WINRAWE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704:SF37">
        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="269" mass="30586" checksum="C601BB2B7193E4C3" modified="2015-04-29" version="1">MVENNDNFEKETGKGFSQRQLKNRWDALRKEWKAWKKLKGEDTGLGWNPIKRTVDASDDWWESRLQVVSEAQKFRTSGIDPEFKGKLDQMFMGIVATGDKAWAPSSGTLRSDFFEDVTNEIPEENEEENRRNDVHISNDVHISNDVQIDGNGQKRKKNLEISSSHFKTGRKKSSKQIGGAARLSGQIEKLCNAADNMSQATSSLTPVMDPYGIPQVVKVLDSMSEEVPEASPLYFFALKLLLNKDKRIMFLSINPKIRALWLKSEMEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGI7</accession>
    <name>A0A0D2SGI7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G195800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SGI7"/>
    <dbReference type="STRING" id="29730.A0A0D2SGI7"/>
    <dbReference type="Gramene" id="KJB43354">
        <property type="protein sequence ID" value="KJB43354"/>
        <property type="gene ID" value="B456_007G195800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009959">
        <property type="term" value="P:negative gravitropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009639">
        <property type="term" value="P:response to red or far red light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040225">
        <property type="entry name" value="GIL1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31161">
        <property type="entry name" value="PROTEIN GRAVITROPIC IN THE LIGHT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="438" mass="50467" checksum="A4C5E86BF0CCDCE4" modified="2015-04-29" version="1">MECMRLGYPPFDQRAYECRVQLTPLTYKGHMRKTDFPQKRKTKLFFWNEDDQRYQKHFPSLLELSSAVNSTIFLSFSLKLFAMPKGEIKIFLGKDMAAEEALDLSTLQSQLSETHEMWNQEMEKHQCQVDFLQDKIMEVKACLQGPEEESKEVDVLWRRVKTTATLLAYLKSKARVMAVPDLAHKSCGIKLLEGVGLVDKEGTPLSGWSRSADLASFDCVDEETWTGISRQQDSLDEQDGAYIGELIKSVQMVTDVMEVLVKRVIMAESETAMEKEKVTLGQEEIKRKAFQIENMSMKLEEMESFALGTNNILNEMRQRVEDLVEETSRQRQRAAENEQELSRVKQDFESLKSYVSSLISVRETLLSSEKQFQTIERLFERLVAKTTQLEGEKKQKEDEVQKLMEENVRLTALLDKKEAQLLAMNEQCKVMALSSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGQ4</accession>
    <name>A0A0D2SGQ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_013G193400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SGQ4"/>
    <dbReference type="STRING" id="29730.A0A0D2SGQ4"/>
    <dbReference type="Gramene" id="KJB82387">
        <property type="protein sequence ID" value="KJB82387"/>
        <property type="gene ID" value="B456_013G193400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS7H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAKEDNR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13301">
        <property type="entry name" value="X-BOX TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB82387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="655" mass="75495" checksum="1CD6CD24F81DEF2C" modified="2015-04-29" version="1">MEWREGEETRMGKNGYLPLFETRPARGLVFFRSYAASIFIGICFICFHRVSYFPVTERWVWVGMFVAELWFSFYFFVTVIVKWNPVFRSTFKDRLSSRYEEEELPGVDIFVCTADPRLEPPTMVVSTVLSVMAYDYPPHKLSVYLSDDGCSDLTFYALLEASGFAQLWLPFCRKLKVEPTSPEAYFQTTPEPVDDAFMANEWLIIKKTYEDMKTRIGSMTRLGKVPADIRKEHKGFDEWDFVVSRHDHPSILQILIDGRDPNAIDIEGKALPYLAREKRPQIHHNFKAGALNALIRISSRISNAPFILNVDCDMHSNDSKAIRDALCFFLDEENGREIGYVQYPQTFGNLTKNEIYGSLRVVMKLELAGFDGNGGPCYIGTGCVHRRESLCGMKYSKELVVEWKAMKYDRKIIEKASSIEGNCKALASCTYEENTPWGKEMGVKYGCVVEDILTGICIQSRGWRSVYLTPQREAFLGMVPTTLLDTLVQHKRWAEGDFQIFQSKLCPFVYGCQNMPLKLQFSYCIYLLWAPNCFATLYYVFVPSFCMLKGISLFPKISSSWGMPYLYVIVVHRVHSLVEFVWLGGTVRGWLNEQRMWMFKRTTSYFFAAIDNILKLCGFSKSAFIITGKVADDDVNRRYEQESMELGLHHRCSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMI4</accession>
    <name>A0A0D2SMI4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G186200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMI4"/>
    <dbReference type="STRING" id="29730.A0A0D2SMI4"/>
    <dbReference type="Gramene" id="KJB43135">
        <property type="protein sequence ID" value="KJB43135"/>
        <property type="gene ID" value="B456_007G186200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43136">
        <property type="protein sequence ID" value="KJB43136"/>
        <property type="gene ID" value="B456_007G186200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803625"/>
    <dbReference type="eggNOG" id="KOG2594">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHACRNI"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010311">
        <property type="term" value="P:lateral root formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="461" mass="50635" checksum="D73468B85364048E" modified="2015-04-29" version="1">MACNSSTCNSSGCYKGYVEEEQPKPNTKAAVNGGNSCQNLCVKCKVNEPVCCGIGGENSRFCKDCFKNNLYGKFKQAVTYNAMITPPDKVLVAFSGGPSSRVVLQFVHEMQYKAQKNYDANKDKSLPVFGVGVAFIDESSTHSFTSQHIEKAIEDIRLIVSNLAPPSKELFVVPIESIFSSDGIDGKERLKELLDAVSDVTGKEDLLSHLRILLLQKIASENGYTRIVLGSCTSRIACHVISATVKGQGYSLSADIQYVDSRWEIPVVLPLRDCPAQELNTLCSLDGSLKIVELLNGPCSGINGLVSSFVKVLQEENPSRECTIVRTAGKLTPFHFNRVPEIHDSNVPSATRRHQKRYTLKPNGSLSSDSFCPICNSPLKKSNFPSSLRSHGSQQNPDLFASACSSCQFQILPKDPSLMEEFLSLLPQQMITKAKHGDQGNFSLLREQIQEFLFSDGENEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SN13</accession>
    <name>A0A0D2SN13_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G312900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SN13"/>
    <dbReference type="STRING" id="29730.A0A0D2SN13"/>
    <dbReference type="Gramene" id="KJB45569">
        <property type="protein sequence ID" value="KJB45569"/>
        <property type="gene ID" value="B456_007G312900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761191"/>
    <dbReference type="eggNOG" id="KOG2898">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB45569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="14768" checksum="951378C632FA2E64" modified="2015-04-29" version="1">MASALNVVQTSHSFGDLMLLMKAAELQQERPWSYMVEMLYHISSLEAVDFLDKFLSMNSDTSGCVKLHDFLDVEKNGSITFKQFLFGIAHVMKKPLLMQACELAFAECDVTNGMQAPWLVEWLVEIGICKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2STK3</accession>
    <name>A0A0D2STK3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">shikimate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="1">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G075100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2STK3"/>
    <dbReference type="STRING" id="29730.A0A0D2STK3"/>
    <dbReference type="Gramene" id="KJB34605">
        <property type="protein sequence ID" value="KJB34605"/>
        <property type="gene ID" value="B456_006G075100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798841"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000142">
        <property type="entry name" value="bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000009">
        <property type="entry name" value="Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000172">
        <property type="entry name" value="Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00214">
        <property type="entry name" value="AroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="7">
        <location>
            <begin position="263"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="6">
        <location>
            <begin position="384"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="8">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB34605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="536" mass="58165" checksum="C7B6F76675228068" modified="2015-04-29" version="1">MDTVNPLLVSSASGLKMDVNGGEMRKNPTLICAPLMADSIDKMVTLMAKAKATTADLVEIRLDSLKNFNPFEDLNVLIKQSPLPTLFTYRPVWEGGQYDGDEKKRLDVLRLAMELGADYIDVELKVAHEFIKSIGGKKPEKIKVIVSSHNYQSTPSVVELGNLVVKIQSTGADIVKIATTAIDITDVARIFQITVHSQVPIIGLVMGERGLISRILCTKFGGYLTFGTLEGGVVSAPGQPTINDLLNLYNFRQLGPDTKVYGIIGKPVGHSKSPMLYNEAFKSAGFNGVFVHLLVDDLEMFLRTYSSTDFAGFSCTIPHKETAVKCCDEVDPVAKSIGAVNCIIRRQSDGKLFGCNTDYIGAISAIEDGLQAGYNMSSAAGSPLAGKLFVVIGAGGAGKALAYGAKQKGARVVIANRTYERARELADVIGGDALSLDDLARFHPEDGMILANTTSIGMQPNIDQTPMPKDALKYYSLVFDAVYTPKITRLLREAKETGATIVSGLEMFIGQAYEQFERFTGLPAPKEQFRRTMSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SWJ6</accession>
    <name>A0A0D2SWJ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G368500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SWJ6"/>
    <dbReference type="STRING" id="29730.A0A0D2SWJ6"/>
    <dbReference type="Gramene" id="KJB46434">
        <property type="protein sequence ID" value="KJB46434"/>
        <property type="gene ID" value="B456_007G368500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB46435">
        <property type="protein sequence ID" value="KJB46435"/>
        <property type="gene ID" value="B456_007G368500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB46436">
        <property type="protein sequence ID" value="KJB46436"/>
        <property type="gene ID" value="B456_007G368500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761743"/>
    <dbReference type="eggNOG" id="KOG4707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="10251781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.20:FF:000001">
        <property type="entry name" value="50S ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_bL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_bL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049946">
        <property type="entry name" value="RIBOSOMAL_L20_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_bL20_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="Ribosomal protein L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB46436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="125" mass="14657" checksum="CE2EA91B2CF7411B" modified="2015-04-29" version="1">MNKKEILKLAKGFRGRAKNCIRIARERVEKALQYSYRDRRNKKRDMRSLWIQRINAGTRQHGVNYGNFMHGLMKENIQLNRKVLSEISMHEPYSFKALVDISRNAFPGNKNVVLPTRKADISINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZR1</accession>
    <name>A0A0D2SZR1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-gulonolactone oxidase</fullName>
            <ecNumber evidence="4">1.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G130100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-gulono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32363"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17587"/>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
            <dbReference type="EC" id="1.1.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; L-ascorbate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.8" evidence="4"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2SZR1"/>
    <dbReference type="STRING" id="29730.A0A0D2SZR1"/>
    <dbReference type="Gramene" id="KJB49629">
        <property type="protein sequence ID" value="KJB49629"/>
        <property type="gene ID" value="B456_008G130100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4730">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCSQDIH"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="UniPathway" id="UPA00132"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050105">
        <property type="term" value="F:L-gulonolactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019853">
        <property type="term" value="P:L-ascorbic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2520:FF:000003">
        <property type="entry name" value="L-gulonolactone oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000033">
        <property type="entry name" value="L-gulonolactone oxidase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007173">
        <property type="entry name" value="ALO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055154">
        <property type="entry name" value="GULLO2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010030">
        <property type="entry name" value="GULO_Plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01677">
        <property type="entry name" value="pln_FAD_oxido"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF67">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04030">
        <property type="entry name" value="ALO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22906">
        <property type="entry name" value="GULLO2-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0060">Ascorbate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002264507" description="L-gulonolactone oxidase" evidence="11">
        <location>
            <begin position="31"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="12">
        <location>
            <begin position="59"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB49629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="589" mass="65093" checksum="A91CBD9BEC8E1041" modified="2015-04-29" version="1">MPAIPMLFSNKFNVLLLWKCLCLLVVLVGCNPPGEPVKCSTKDSNCTVTNSYGMFPDRAICRAGNVAYPTSEQELVSIVSAATKSKRKMKVVTHFSHSIPKLVCPDGQDGLLVSTKNLNRVLKTDTEAMTMTVESGVTLRQLIKEAAKAGLALPYAPYWWGLTIGGLLGTGAHGSSLWGKGSSVHDYVVEMRIVSPAKAEDGYAKVWVLNERDKDLDAAKVSLGVLGVISQVTFKLQPLFKRSITYVRKDDTDLGDEAVTFGKLHEFADIFWYPSQRKAIYRIDDRVPINVSGNGVYNFTPFRSTLSLVLALVRSSEETQESSGDAEGKCLNAKLVTSTLQSSVYGLTNNGAIFTGYPVIGFHNRLQSSGTCLDSLEDSLITACPWDPRIKGEFFHQTTFSIGLSVVKSFIQDVQKLVSMDPKSLCGLELYNGILMRYVKASTAYLGKQEDAIDFDITYYRSKDPMAPRLYQDVLEEIEQMALLKYNALPHWGKNRNLVFDGVMKRYKNGGEFLKVKNKYDPWGLFSSEWTDQVLGLRNGVIVLKEGCALEGLCICSQDVHCAPSKGYLCKPGKTFPDARVCARVNTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T0I2</accession>
    <name>A0A0D2T0I2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G145600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T0I2"/>
    <dbReference type="STRING" id="29730.A0A0D2T0I2"/>
    <dbReference type="Gramene" id="KJB49914">
        <property type="protein sequence ID" value="KJB49914"/>
        <property type="gene ID" value="B456_008G145600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764119"/>
    <dbReference type="eggNOG" id="ENOG502QQ62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPEVKYP"/>
    <dbReference type="OrthoDB" id="730977at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040267">
        <property type="entry name" value="EID1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31348">
        <property type="entry name" value="EID1-LIKE F-BOX PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31348:SF4">
        <property type="entry name" value="PHYTOCHROME A-ASSOCIATED F-BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="6"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB49914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="327" mass="36951" checksum="1194C4603CF03351" modified="2015-04-29" version="1">MTETPFSKLSDDVVLNIFSKLEHHPKSWACLACVCTKFSSLIHNTCFKQKCFKTIPAVCAGLLSSSSVPPGGWSSLHKLSVCCPGLHHAGVLLDHSDFGFAREIGPEVKYPKLANSQFSPPPTEPWSSKVEGNPNPDPENNAPGSDCSWSLFDDLCYDTVSNPSESIDGYKVERIDNRDIKTGREFLVCKRRKLSRPLRSHLADGVWNLSREQGNKLLASRFRGDCLYICDWPGCIHMEEKRNYMLFRGVFNDFKKSRVWRTINDGNRRKIDLSCAFCSCKQTWDLHSAFCLRRVFGYHDDGEPVVRAYVCENGHVSGAWTDLPLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T0U7</accession>
    <name>A0A0D2T0U7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G052700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T0U7"/>
    <dbReference type="STRING" id="29730.A0A0D2T0U7"/>
    <dbReference type="Gramene" id="KJB48081">
        <property type="protein sequence ID" value="KJB48081"/>
        <property type="gene ID" value="B456_008G052700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB48082">
        <property type="protein sequence ID" value="KJB48082"/>
        <property type="gene ID" value="B456_008G052700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0474">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRKESHY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB48081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="12254" checksum="DF52D5C89230C52E" modified="2015-04-29" version="1">MLGKHLRRAHLVQALKKKWLLPDNRRTEELEVKEKFNWVELAERELKIEQVVDIKRFVRSSASRVVGIVESVKRERVRGRVKEGWEKGLFGRFRKESHYCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1S7</accession>
    <name>A0A0D2T1S7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_011G035100</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Putative 5'-&gt;3' double-stranded DNA exonuclease which may also contain a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. May be involved in DNA mismatch repair (MMR).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1S7"/>
    <dbReference type="STRING" id="29730.A0A0D2T1S7"/>
    <dbReference type="Gramene" id="KJB69638">
        <property type="protein sequence ID" value="KJB69638"/>
        <property type="gene ID" value="B456_011G035100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2518">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0228">DNA excision</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="19">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="18">
        <location>
            <begin position="138"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="469"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="394"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00060210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB69638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="691" mass="77057" checksum="EA640EBFEDBA09A4" modified="2015-04-29" version="1">MGIQGLLPLLKSIMVPIHIKELEGCSVAIDTYSWLHKGALSCSTQLCKGLPTSRHIEYCMHRVNLLRHHGVKPVLVFDGGLLPMKIEQENKRARARKENLARAVEHESCGNSAAAYECYQKAVDISPSIANELIMVLKRENVCYVVAPYEADAQMTFLAISKQVDAVITEDSDLIPFGCPRVIFKMDKFGQGVEFKSSMLQQNKELSFAGFTKQMLLEMCILSGCDYLQSLPGMGLRRAHALMKKFKSYDKVIKHLRYSTVSVPPLYEESFKKAILTFQCQRVYDPITEDIVHLSDISDNIGDDLDFLGPPIPQQIAQGIARGDLDPFTQMPFQAVRDGSQLALDRNLQLKSFKPESERKRLYLPVQKNLLTNYFCFASVEARRNFKAPRVSPKHSSPVANSSISPESDKDITVEDGSCQIDTLLSASPEFKNTNSIEENGFITKLPEYSESPNPDIEAKVDTMRSPDHVLPLESDRPTIRPPTASDKEHDNNTVPDAAKSKTITDSRKSIVTSRYFQKKQVDINDQEDKQGKNCCKGGITNQFPETGNLDGYGNTYFKGMASKRKNSFEYVETENVNPKQIYTNASCDGNGDCGPNLETFVETKTGEAKFGSNISHLGHYSDVAEKSMERFVSVISSFRFSSPGSRASGLRAPLKDARNTCNNRSSAAVDFSQFAYVPKTKKAKLASPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T311</accession>
    <name>A0A0D2T311_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_004G040400</name>
        <name evidence="14" type="ORF">B456_004G277200</name>
        <name evidence="15" type="ORF">B456_009G018200</name>
        <name evidence="16" type="ORF">B456_011G056400</name>
        <name evidence="17" type="ORF">B456_011G056500</name>
        <name evidence="18" type="ORF">B456_013G250500</name>
        <name evidence="25" type="ORF">Gorai_003694</name>
        <name evidence="22" type="ORF">Gorai_005409</name>
        <name evidence="23" type="ORF">Gorai_005410</name>
        <name evidence="24" type="ORF">Gorai_005767</name>
        <name evidence="21" type="ORF">Gorai_010890</name>
        <name evidence="19" type="ORF">Gorai_014057</name>
        <name evidence="20" type="ORF">Gorai_015710</name>
    </gene>
    <organism evidence="16 26">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 26" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <source>
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    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <sequence length="136" mass="15268" checksum="F1FB03A849777A61" modified="2015-04-29" version="1">MARTKQTARKSTGGKAPRKQLATKAARKSAPATGGVKKPHRFRPGTVALREIRKYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVAALQEAAEAYLVGLFEDTNLCAIHAKRVTIMPKDIQLARRIRGERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
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            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2T411"/>
    <dbReference type="Gramene" id="KJB49216">
        <property type="protein sequence ID" value="KJB49216"/>
        <property type="gene ID" value="B456_008G107100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763730"/>
    <dbReference type="eggNOG" id="KOG1831">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000012">
        <property type="entry name" value="Ccr4-Not transcription complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.800:FF:000001">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.790:FF:000002">
        <property type="entry name" value="Transcription regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.840:FF:000003">
        <property type="entry name" value="Transcription regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055454">
        <property type="entry name" value="CNOT1-like_NOT1_connector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032194">
        <property type="entry name" value="CNOT1_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25097">
        <property type="entry name" value="ARM_Cnot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16418">
        <property type="entry name" value="CNOT1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 HEAT repeat" evidence="11">
        <location>
            <begin position="477"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="647"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1308"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1-like NOT1 connector" evidence="12">
        <location>
            <begin position="1646"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="2027"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="838"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1605"/>
            <end position="1626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1831"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="838"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1498"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1836"/>
            <end position="1860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB49216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2413" mass="266899" checksum="2B2B2CB95C522B5F" modified="2015-04-29" version="1">MLELSSTLSSHVRFLLQSLTEANADSVFRELCQFIEYGIEGSTLVLQTCLDCLSSHKTDSKNLQSEQVVASIFRHAMDKPNFCTVFCQSLRSMDISENFLENFSKTLQLSLSEKIAVGLALSDSENPETRMCGKNFCMAQIEELQSNPACPDSSMQIQNMVMFLQCSSAFSKHVDSFMQMLSLVQAKDVAQFVLTPILSDELREANFLRNIDFFDESEENDFDALLAEMEKEMSMGDIIKELGYGCTTDAAHCKEILSLYLPLTEVTISRILGAITRTYVGLEDNQIAFSTFSLALGCGNSLDLPPLSSWNVDVLIKTIKQLAPNTNWVQVIEHLDHEGFYIPNETAFTFFMSVYQHSCQEPFPLHAVCGSVWKNIEGQLSFLKYAVEAPPEVFTFAHSVRQLDYAEAVHGHKLQIGNGNHAWLCLDLLDVLCQLAERGHASFVRSMLDYSLKHCPEILLIGMAHVNTAYNLLQHDVTSSVFLMIIKNAVGAGTILQLWHVNPKVVLRGFVEVQNTEPDSMIRILDICQELNILSSVLEMMPFPSAIRLAVLASRKEVIDFEKWLSSILNMYKDVFFEECLKFLKEIQFGGSQEFSAKPFHHTTAVLNLYLEASTTFFKILKANSGSITSTQLLEEMERLHVTIMDSTSKLQNGGTTVSSPSDGYGDEIEAEANSYFHQMFSGQLTIDAMVEMLSRFKESSVKREQSIFECMIANLFEEYRFFHKYPERQLKIAAVLFGSVIKQQLVTHLTLGIALRGVLDALRKPADSKMFLFGTKALEQFVDRLIEWPQYCNHILQISHMRATHSELVAFIERALARISSGHLESTGSNNLSVHHQVSSQVTPGNGELNSSSIIQSGPQLSSPLRLPRHDSSLDDRNKASAASSNDVKPLLPSVGQPSVASLSDASSIQKPQNAVTSASMLSASPGFVRPSRGVTSTRFGSALNIETLVAAAERRETPIEAPTSDIQDKISFIINNISVANIEAKGKEFTEILKEQYYPWFAQYMVMKRASIEPNFHDLYLKFLDKVNSKALNKEIIQATYENCKVLLGSELIKSSSEERSLLKNLGSWLGKLTIGRNQVLRAREIDPKSLIIEAYEKGLMIAVIPFTSKILEPCQSSLAYQPPNPWTMGILALLAEIYSMPNLKMNLKFDIEVLFKNLGVDMKDITPTSLLKDRKRELEGNPDFSNKDVGASQPQMVPEAKTGIISPLNHVDIPLEVASPPNPGGHTHLLSQYAGPLRLSSGALVEDEKLAALGLSDQLPSAQGLFQASPSQSPFSVSQLSTPIPNIGTHVIINQKLSALGLHLHFQRVVPIAMDRAIKEIVAGIVQRSVSIATQTTKELVLKDYAMESDETRIYNAAHLMVASLAGSLAHVTCKEPLRGSISSQLRSSLQGLNVGSDLLEQAVQLVTNDNLDLGCAVIEQAATDKAIQTIDGEIANQLALRRKHRDPAFFDPSMYGQGSMGVVPEALRPKPGHLTVSQQRVYEDFVRLPWQNQSGQTTHTMSAGPSTSPGDTGLTGTFGSTSGQVTPGYTSGPGNLGQADVASEAIETTSASLLSVPSVHIGSGTGLTQQTTENDPLNASFPSTTAAPELLSVETTDAVKEFGPTSQSLPSPAATERLGSSISETSLSTRDALDKYQIVAQKLENLVTSDGREADIQGVISEVPEIILRCVSRDEAALAVAQKVFKGLYENASNSLHVSAHLAILAAVRDVCKLAVKELTSWVIYSEDERKFNKDITVGLIRSELLNLAEYNVHMAKYIDGGRNKAATEFAVSLLQTLVSDESRVISELHNLVDALAKVASKPGAPESLQQLIEMIRNPSASMAALSSATVAKEDKAKQSRDKKGPSHAPANREDNSSMEALEPDPAGFKEQVSMLFAEWYQICELPGANDGPCNHYILQLYQNGLLKGDDMTERFFRIITELSVAHCLSSEVMSSGALQSPQQAQTLSFLAIDIYAKLVLAILKYCPVEQGSSKLFLMSKILTVTVRFIQKDAEDKKASFNPRPYFRLFINWLLDLGSLDPVTDGANFQILTAFANAFHALQPLKVPSFCFAWLELVSHRTFMPKLLTGNSQKGWPYIQRLLVDLLQFLEPFLRNAELGVPVHFLYKGTLRVLLVLLHDFPEFLCDYHFTFCDVIPPSCIQMRNIILSAFPRNMRLPDPSTPNLKIDLLPEIRESPRILSEVDAALKAKQMKADVDEYLKTRPQGGCSFLTELKQRLLLSPSEAASAGTRYNVPLINSLVLYVGMQAIQQLQSRVPHAQATANTVPMSVFLVSAALDIFQSLIGDLDTEGRYLFLNAIANQLRYPNSHTHYFSFILLYSFAEANQEIIQEQITRVLLERLIVNKPHPWGLLITFIELIKNPRYNFWNRSFIRCAPEIEKLFESVARSCGGLKPVDEGMVSGWVSETAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T9K9</accession>
    <name>A0A0D2T9K9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G059500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T9K9"/>
    <dbReference type="STRING" id="29730.A0A0D2T9K9"/>
    <dbReference type="Gramene" id="KJB40345">
        <property type="protein sequence ID" value="KJB40345"/>
        <property type="gene ID" value="B456_007G059500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0251">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VMNRLHT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF76">
        <property type="entry name" value="OS09G0468150 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB40345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="309" mass="34690" checksum="7B775B568431D5DA" modified="2015-04-29" version="1">MGRIPILRDFIGIIKDKASQSKAALLSDPKTLSLHLALLRATTHDPFTPPDPRHLATLLASGHTSRATVSTAIEYPSNGGRNYLKLSNFRDKTTLLTWELSYWVRWYALYLENLLQTSRVLGFFLSSASSSVDNNEEEEEKVSSLTNSQLLKEINSLGNLIEQISRMPNSLHTNGNILVDEVLGMVGEDYLASTNEVSIRVSEFKERLSCLSVFESVELGFALKRLEDCKERLSALGQMRNVLVETVWGSISEMKDQVGNDELYGEEGRLMTMESSKNKVSESSRYGERVLKLGDSVDFFSGRFSKLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCU1</accession>
    <name>A0A0D2TCU1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">threonine synthase</fullName>
            <ecNumber evidence="7">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_009G034200</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="7"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCU1"/>
    <dbReference type="STRING" id="29730.A0A0D2TCU1"/>
    <dbReference type="Gramene" id="KJB54439">
        <property type="protein sequence ID" value="KJB54439"/>
        <property type="gene ID" value="B456_009G034200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769017"/>
    <dbReference type="eggNOG" id="ENOG502QSQC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MWGFQAS"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01563">
        <property type="entry name" value="Thr-synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000030">
        <property type="entry name" value="Threonine synthase 1, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0934">Plastid</keyword>
    <keyword evidence="14 18" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="13" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="15" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="20">
        <location>
            <begin position="173"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="18">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB54439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="534" mass="58771" checksum="1A037488A3AB2513" modified="2015-04-29" version="1">MAYSCSLFHSSLASKSNFPLLHHRNHPKFNRPAPIVISCSSSSTFDPSSTTSSSNNNTPSPQKNRRLADENIRDEARRHRSTAKNTLSAKYVPFNAGPDCTESYSLDEIVYRSRSGGLLDVQHDMEALKKFDGAYWRELFDSRVGKTTWPYGSGVWSKKEWVLPEIDPDDIVSAFEGNSNLFWAERFGKQFLGMNDLWVKHCGISHTGSFKDLGMTVLVSQVNRLRKLKRPVVGVGCASTGDTSAALSAYCAAAGIPSIVFLPANKISIAQLVQPIANGAFVLSIDTDFDGCMKLIREVTAELPIYLANSLNSLRLEGQKTAAIEILQQFDWEVPDWVIVPGGNLGNIYAFYKGFKMCQELGLVDRIPRLVCAQAANANPLYLYFKSEWNEFKAVKANTTFASAIQIGDPVSIDRAVYALKNSNGIVEEATEEELMDAMAQADSTGMFICPHTGVALTALMKLRKSGVIGAGDRTVVVSTAHGLKFTQSKVDYHSKEIPDMACQFANPPMQVRADFGSVMDVLMKYLGDKSPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TDF0</accession>
    <name>A0A0D2TDF0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Outer envelope pore protein 37, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G266600</name>
        <name evidence="3" type="ORF">Gorai_010524</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TDF0"/>
    <dbReference type="STRING" id="29730.A0A0D2TDF0"/>
    <dbReference type="Gramene" id="KJB52536">
        <property type="protein sequence ID" value="KJB52536"/>
        <property type="gene ID" value="B456_008G266600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765427"/>
    <dbReference type="eggNOG" id="ENOG502QQCE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YSNNWSA"/>
    <dbReference type="OrthoDB" id="2011802at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009707">
        <property type="term" value="C:chloroplast outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:monoatomic cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038951">
        <property type="entry name" value="OEP37-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35484">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 37, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35484:SF2">
        <property type="entry name" value="OUTER ENVELOPE PORE PROTEIN 37, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB52536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0593589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38874" checksum="A9971AC8EA8AC39B" modified="2015-04-29" version="1">MLEPSSQKPNFLIPQVSPTPAAPPPPMAQPPPSPPPPSLVRTYSGKLLSLLSERPSLRATSEFDSDSRVFFHKVSCKLFDNLASLKLSFINDSKREISEPQLMLTSKYLSIHYDPDEQNALIRTSFDVGPMLNFNVAHDLKAQQGEVSMYASLPSPGFGVQVSSSFPYSGLPRATIRFPMGEVTLEEREEADVLRTLSVKGILRGQILNGVCSAHYVDEELKLRYIYKDQAMSFIPSISIPSNAVSFAFKRRLSPSDKLSYWYKLYSNNWSAVYKHTYKKSFKLKAGYDSEVRLGWASIWVGDKNGRARTAPMKMKVQFMLQVPQDDIKSSTLMFRVKKRWDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGA3</accession>
    <name>A0A0D2TGA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="6">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_012G008200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the choline monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="6"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGA3"/>
    <dbReference type="STRING" id="29730.A0A0D2TGA3"/>
    <dbReference type="Gramene" id="KJB74798">
        <property type="protein sequence ID" value="KJB74798"/>
        <property type="gene ID" value="B456_012G008200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIMVEWY"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd08883">
        <property type="entry name" value="RHO_alpha_C_CMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Rieske" evidence="16">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB74798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="411" mass="46729" checksum="1F491678F25F047F" modified="2015-04-29" version="1">MTLLLKPITRLSLFQTHFQINNNNNPRARETSVSCSWSHGAHKIVREFDPKIPIEKAITPPSSWYTDPSFYAFELDRVFYRGWQAVGYTEQIQEPRDFFSGRLGNVEFVVCRDDNGKIAAFHNVCRHHASLLVSGSGKTSCFTCPYHGWTYGLNGELRKATRISGIEDFSINDFGLVPIKVATWGPFVILNMDNEILQKDNIDTDNVASEWLGSSSELFSLNGVDTTLTYVCRREYIIECNWKVFCDNYLDGGYHVPFAHKGLASGLSLDSYTTSIFEKVSIQSAEGGSKEKEDDRLGSKAFYAFIYPNFMINRYGPWMDTNLAIPLGPRKCLVVFDYFLEASFKDDKAFIERSLADSEKVQENTQMEDIRLCEGVQKGIESPAYSTGRYAPNVEKAMHHFHCLLYDNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2THA6</accession>
    <name>A0A0D2THA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G183700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2THA6"/>
    <dbReference type="STRING" id="29730.A0A0D2THA6"/>
    <dbReference type="Gramene" id="KJB43090">
        <property type="protein sequence ID" value="KJB43090"/>
        <property type="gene ID" value="B456_007G183700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERENCGH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032872">
        <property type="entry name" value="WAK_assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138">
        <property type="entry name" value="OS01G0690200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33138:SF72">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE CARBOXY-TERMINAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14380">
        <property type="entry name" value="WAK_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267863" description="non-specific serine/threonine protein kinase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="11">
        <location>
            <begin position="31"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase C-terminal" evidence="12">
        <location>
            <begin position="169"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="276" mass="30157" checksum="139AD3254FEAA719" modified="2015-04-29" version="1">MPSKFSFTIIIISLVLILSPKPVFSNNYLSCSVRSSCGNISDIGYPFWGLDRPESCGYPGFKLSCSESELEITISSATYRVLAINKESQTLHVSRTDYSENLCPTHLINSTFESETSPFRQNGDSQDIRLYYGCQPLTAPQNLTSILGISNQFDCTINNTKIVGYYVTREFAGTVTGNFLRSCSNSVIIPVPNSQVPSLEEGRDPDDLEEAAKIGFQLWWSADDTRCNNCVNKGGQCGRNLVSGGFECYCSDGDVCSPGTIFVVCCTCSNISCSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2THR6</accession>
    <name>A0A0D2THR6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AP2/ERF and B3 domain-containing transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G020300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP2/ERF transcription factor family. RAV subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2THR6"/>
    <dbReference type="Gramene" id="KJB54096">
        <property type="protein sequence ID" value="KJB54096"/>
        <property type="gene ID" value="B456_009G020300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766746"/>
    <dbReference type="eggNOG" id="ENOG502QQEC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDTHRNF"/>
    <dbReference type="OrthoDB" id="2020802at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000008">
        <property type="entry name" value="AP2 domain-containing protein RAP2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044800">
        <property type="entry name" value="LEC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR ABI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140:SF58">
        <property type="entry name" value="DNA-BINDING PROTEIN RAV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="44"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="9">
        <location>
            <begin position="162"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB54096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="38910" checksum="21A976433B5FBA3D" modified="2015-04-29" version="1">MEEEITSVILSGEANTHSDVSDSTSTTHQANKRQRCGGKGNSSQYKGVMRQKNGQWGAQLYANHTRIWLGTFKSEIDAAMAYDSAAIKFRTEDTHRNFPWNEITIEEPKFLSHYSVEIVLSMIRDGSYQYKFMDFIKAHSRNTKLNLVGTYSNEGLICKQLFQKELTPSDVGKLNRLVIPKKYAVKYFSPVFGTENENADVGDRKTNDVELVFYDKFMRIWKVRYCYWNSSQSFVFTRGWNRFLKEKELKAKDVVSFFVCECRKENDVQRFCMIDANKSGNGGTFVAENNVHVGIEVDLQLRLGHSYLVQEEQRSMAAAKPKQDDKTEGFKLFGMQIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2THT6</accession>
    <name>A0A0D2THT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAGA-associated factor 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G112000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the SGF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2THT6"/>
    <dbReference type="STRING" id="29730.A0A0D2THT6"/>
    <dbReference type="Gramene" id="KJB56244">
        <property type="protein sequence ID" value="KJB56244"/>
        <property type="gene ID" value="B456_009G112000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2612">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071819">
        <property type="term" value="C:DUBm complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000118">
        <property type="entry name" value="Ataxin-7-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013246">
        <property type="entry name" value="SAGA_su_Sgf11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47674">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47674:SF3">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08209">
        <property type="entry name" value="Sgf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0010">Activator</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU261113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB56244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="88" mass="9544" checksum="57F19EE4BD34E440" modified="2015-04-29" version="1">MSGPNEESTQLSLLIFGDLLDSIIVDVASESHRIAKLGLDPKLEEEEEESHPSVASVIFDCMNCGRSIAAGRFAPHSEKCMGKGRKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TN02</accession>
    <name>A0A0D2TN02_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G283200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TN02"/>
    <dbReference type="STRING" id="29730.A0A0D2TN02"/>
    <dbReference type="Gramene" id="KJB44975">
        <property type="protein sequence ID" value="KJB44975"/>
        <property type="gene ID" value="B456_007G283200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1575">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPTINAP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19145">
        <property type="entry name" value="AKR_AKR13D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF81">
        <property type="entry name" value="OS01G0618100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB44975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="350" mass="38919" checksum="48C9A7DA8B2B69B2" modified="2015-04-29" version="1">MGEEQQRIQIPRVKLGTQGLEVSKLGFGCMGLTGGYSSPVSEEVGISIIKHAFHRGITFFDTSDIYGPKTNEILVGKALKQLPREKVQLATKFSFEKLDSTGIKINGTPEYVCASIEASLKRLDVDYIDLYYQHRVDTNTPIEDTMSELKKLVEEGKIKYIGLSQASPETIKRAHAVHPISAFQTEWSLWTRDIEDEIVPLCRELGIGIVPYSPLGHGFFGGKGVVETVPANSHLLYFPRFQGENLDKNKMLYFKVEKLAEKHGCSPAQLALAWVLHQGDDVAPIPGTTKIKNLDSNIDSVKVKLTAEDLKEISDVVPINEVAGDVLPDRFNQLHWKFGNTPPKRSKVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TNA6</accession>
    <name>A0A0D2TNA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_009G206000</name>
        <name evidence="19" type="ORF">Gorai_012336</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="6"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TNA6"/>
    <dbReference type="STRING" id="29730.A0A0D2TNA6"/>
    <dbReference type="Gramene" id="KJB58354">
        <property type="protein sequence ID" value="KJB58354"/>
        <property type="gene ID" value="B456_009G206000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769141"/>
    <dbReference type="eggNOG" id="KOG1815">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAMCTEA"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000027">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="170"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="174"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="16">
        <location>
            <begin position="610"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB58354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0595467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="639" mass="71435" checksum="853DAE864A8013E6" modified="2015-04-29" version="1">MAASDSDDVNLAYDDTADDDYFCLDDTDEDLHPPQASDSLDDDQLQGSDSRNDDDDDLLQSSDRHDDGDHDCDDNDDGDENALEEDDHDSPISGQNFSVLTEADIRHRIKDNIAEVSSVLSISKNEASSLLLHYNWSVNNIFDSWFADEKAAREKAGLFLEPLIESPDHGSSICVICFEDYPCDETKSTSCGHRYCNDCWSSYIKTAISDGPQSLLLTCPHPSCRAAVGEDMVGLFASEKEKNKYSSYIVMSYIESKKMIKWCPGPGCENAIDFVAGSENLDVSCLCSHSFCWNCTQDAHRPVDCETVTKWMSKNSSESGNVNYILAFTKPCPKCKRPIEKNMGCSHMTCRAPCLYEFCWLCLGDWNNHGTCNRFKGNPEEEKREKAKQYVMKYTHYFERWATNQNSMKKGAADLQKVQTEQIEVLSRIQAQPLAQISFVTEAWKQIIECRRVLAWTYAYGFYLPEECEAKRNLFEYLQGQAESGLERLHDCAEKELQSYLKDKISVEGFIEFRKKLTLLTRVTRNYFDNLVAALQNGLSDVNSGSSSVSKKRKSNWAAAAVNAAPVLDTNINDNSATAPAAAASAMEPWACAYCSYENQSSATNCAMCGRGSWTCDVCTYANSRTSATCAMCTEAPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSJ2</accession>
    <name>A0A0D2TSJ2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G368900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSJ2"/>
    <dbReference type="Gramene" id="KJB46445">
        <property type="protein sequence ID" value="KJB46445"/>
        <property type="gene ID" value="B456_007G368900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB46445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="77" mass="8804" checksum="47BD3A40977CC120" modified="2015-04-29" version="1">MQPSIIILVLNFSSYQSGVAFLHGSSFRSFINILVHFKGWQLDSEKMSSLQPFHGFVQKNLLLMSLLHLIKIKEICP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TY67</accession>
    <name>A0A0D2TY67_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G311500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.5) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TY67"/>
    <dbReference type="SMR" id="A0A0D2TY67"/>
    <dbReference type="STRING" id="29730.A0A0D2TY67"/>
    <dbReference type="Gramene" id="KJB60546">
        <property type="protein sequence ID" value="KJB60546"/>
        <property type="gene ID" value="B456_009G311500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770914"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKWTHIA"/>
    <dbReference type="OrthoDB" id="655540at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000047">
        <property type="entry name" value="Amino acid transporter AVT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF692">
        <property type="entry name" value="TRANSMEMBRANE AMINO ACID TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="164"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB60546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="553" mass="60085" checksum="0076DD4B2AA662E6" modified="2015-04-29" version="1">MKNSVSDHSFYIESDEEDEEKVFIPDENGEEVDGNESDDSDSSAENQQQNKPGSYNTSWPQSYRQSIDLYSSVPSPSIGFLGTPTLSRLSSSYLSSSLTRRHTPETLSSATKPLLPTVDDQIEPHRRSSHALLPPIPSRRQSVRLDDKTSSKVSHEISLPRHCTNGQAVLNGINVLCGVGILSTPYAAKEGGWLGLIILFTFALLSFYTGLLLRQCLDSQPGLETYPDIGQAAFGTYGRIALSIILYVELYACCVEYIILEGDNLASLFPNAYVSLGGLELSPQRLFALMATLAVLPTVWLRDLSVLSYISAGGVVASILAVLCLFWVGLIDQVGFHNKGTTLNIATLPVAVGLYGYCYSGHAVFPNIYTSMANPNKFPSVLIACFAICSLLYAGTAVMGYTMFGEATESQFTLNMPKDLIASKIAVWTTVVNPFTKYALTMSPVAMSLEELIPSTHLKSHIYAIIIRTSLVISTLIVGLTIPFFGLVMSLIGSLLTMLVTLILPPACYLSILRGKVTRIQRTLCIMVITVGVVSSAFGTYSALSKIVENLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYX8</accession>
    <name>A0A0D2TYX8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein NUP58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G072400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TYX8"/>
    <dbReference type="STRING" id="29730.A0A0D2TYX8"/>
    <dbReference type="Gramene" id="KJB48500">
        <property type="protein sequence ID" value="KJB48500"/>
        <property type="gene ID" value="B456_008G072400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763331"/>
    <dbReference type="eggNOG" id="ENOG502QR16">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYSTKWA"/>
    <dbReference type="OrthoDB" id="2538017at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024882">
        <property type="entry name" value="NUP58/p45/49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437">
        <property type="entry name" value="NUCLEOPORIN P58/P45 NUCLEOPORIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13437:SF2">
        <property type="entry name" value="NUCLEOPORIN P58_P45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB48500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="52822" checksum="4D7A2E231069F387" modified="2015-04-29" version="1">MSSFFATPQPQQSPPLFQPQQQPFQQSYSPFYQSQQQQQQQQQQPQLQFPQQQQQQQQQQQQQQPLFLFTNDKTPASYSTKWADLHPDSQKFLLQIEERILEYRDESQRLDQCTRLYDSSVSNEGFELDASHIVQELGGISTAMERQKALLQELMSTVKDMLRNTEVAVRSFMMLRPRFVHSNTGGASNATAPSQAPGPTTTPGSGAQPTAASMVPVFDFYHGLPKKPSPFLQYTVARFEKYLGECRQWIEELEQLLLLNSDRNSINHASSLLQSLPKVMSNVHDFFIHVAAKVESIHQYIESMKTAYLADHRHRGDVNDPFLEADRRETAKQEAAAKRVHPTLHLPANSQPSTQVAGLFASSAAPAAASAPQTSAATSAASSGGGLSLFSTPSSTPASSMSSSLFATPTTGASIQTSLFSSSSGPLLGSASTPSLFASTVPAFGSTASAGGSLFSTPFASGAPTGSGASFGAASKSSRPKSRTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2R2</accession>
    <name>A0A0D2U2R2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G407800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2R2"/>
    <dbReference type="STRING" id="29730.A0A0D2U2R2"/>
    <dbReference type="Gramene" id="KJB62241">
        <property type="protein sequence ID" value="KJB62241"/>
        <property type="gene ID" value="B456_009G407800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766722"/>
    <dbReference type="eggNOG" id="KOG2071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000023">
        <property type="entry name" value="polyadenylation and cleavage factor homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057242">
        <property type="entry name" value="PCFS4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23228">
        <property type="entry name" value="zf_PCFS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="79"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="419"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="556"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="712"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="776"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB62241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1032" mass="111489" checksum="08D3728429E3A68E" modified="2015-04-29" version="1">MENPRRSFDRSREPGLKKPRLTEDLTPNPNIRPFSQRANPVAASGLRSRSNDSDINDLISGDGGAYEPQPVSHQQQHQQQQELVSQYKMALAELTFNSKPIITNLTIIAGENVHAAKAIAATVCANILEVPSDQKLPSLYLLDSIVKNIGRDYIKCFAARLPEVFCKAYKQVDPPLHQSMRHLFGTWKGVFPVQTLQVIEKELGFTPLVNGSSSGNTTSRTDTLSQRPPQSIHVNPKYLEKQRLQQSIKVNLAKGIVNDMAGTLANSKEESEKCFKIPGIEVRRTRGNVTDQGLDAPWFRATSSVTETIPSQRNGFNVKHGSQNYSASKSVNADPRLHRTHNISGRNSGGLSSSWKNSEEEEFMWEMHSRLSEHDATNFSNNLRKDCWTPDVSEKMDFESQLHRPQSIHDAVSRFDRETSADALSTEQKDKPSFGRQISTSWTDGLPAISSSRSESYSASLGGLPTGASSSLARIGMRPQTSSSHLGTPGFGFLANVASGPTGTSGKQCFQSVGTASPPEQSPMRQHSPSPSFPACHSHQQLQKLADPDYQQVLSLPRADPKPSIFSGKLNVGSHRDSPQTSAPISLHPSRHYHLSQPPLPGSVQAEPSGQTQKSLLSQISKVEAASALGSALERSNPLAIETSELSSTSSLLAAVMKTGILSSTSFTGNLPTKISQDVGQISQPPLPNCPPVFTTSGLIDAAVSSDATHDAIAGAPNSSQEKVEQLPLPPGPQPSSLVSNAPSQTSDAESKDTNPISNLLSSLVAKGLISASKKDAASLPSLPMPNQIQKSPGVESPSESLNKSSDIQSSSDAPRSSTMDEVSYAEPAPKCLVAPHQSTSTEVESLIGLELRPDVIREFHSSVIGGLLDDLPHCCSLCGLRLKLQGQLDRHLEWHEMKKTELRGSGRALRGWYVRSDDWLAGKPGQLVLDSTDSLNKLEKTTEKAERMVPADENQCACLLCGELFEDYFRLDSGEWMFKGAAYLAIPSKEGGVGTTDGSAANGPIVHANCMSESSVRDLGLSGGIKVEMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5C5</accession>
    <name>A0A0D2U5C5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G3840001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5C5"/>
    <dbReference type="Gramene" id="KJB63181">
        <property type="protein sequence ID" value="KJB63181"/>
        <property type="gene ID" value="B456_009G3840001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQRNRVF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
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                <person name="Shu S."/>
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                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Romanel E."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
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                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
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                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Wang Z."/>
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                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Wang Z."/>
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                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UW46"/>
    <dbReference type="Gramene" id="KJB60337">
        <property type="protein sequence ID" value="KJB60337"/>
        <property type="gene ID" value="B456_009G301100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60338">
        <property type="protein sequence ID" value="KJB60338"/>
        <property type="gene ID" value="B456_009G301100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60339">
        <property type="protein sequence ID" value="KJB60339"/>
        <property type="gene ID" value="B456_009G301100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60340">
        <property type="protein sequence ID" value="KJB60340"/>
        <property type="gene ID" value="B456_009G301100"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:pollen sperm cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Transcription factor GAMYB"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47995">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47995:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="88"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60464" checksum="59CA68914126297E" modified="2015-04-29" version="1">MSHTKHEREDGMLSKDQTESPLIDDGSCGGGGAGGVVLKKGPWTSAEDAILIDYVKKHGEGNWNAVQKHSGLFRCGKSCRLRWANHLRPNLKKGAFTQEEEQLIIELHAKMGNKWARMAAHMPGRTDNEIKNYWNTRIKRRQRAGLPLYPPEVCLQALQESHSTSVVNALDKGPNDILQNNSYEIPDVIFDSLKANQNVLPYVPELPVLSASSMLMKGLGSSQYCGFMQPTIHRQKRLRESPAFFPGYTGAVKNECPLFMQFQEDISDKAAGSFGLSFPIEPDPAAKNSQPFGVFPGSHTLSNGNFSASEPPLEAVKLELPSLQYPETELGNWGTLTCPPPLLESVDAFIQSPPPTSGLESDSLSPRNSGLLDALLHEAKTLSSAKNHASDKSSNSSTPGDIAEGSNFNICETEWEKCGEPLSPMGNSATSIFSECISASGSSLDEQPPAETVTESHVKSEPADRVLTPEIQKEAPIRLDSSGPDTLLASNWLEQGSGYDKDQAILTDAISSLLGDDLRSEYKNMEEGTSISSQAWGLDSCAWNNMPAVCQMSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYU3</accession>
    <name>A0A0D2UYU3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G281000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB74231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB74231">
        <property type="protein sequence ID" value="KJB74231"/>
        <property type="gene ID" value="B456_011G281000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAQDAYD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF84">
        <property type="entry name" value="RIBONUCLEASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB74231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="276" mass="31114" checksum="0C151880691EFEA7" modified="2015-04-29" version="1">MQLLLQYANETAHLKPPQEYVPWVVVNNQPLRQVITSIFISWLLDFENFVKYVCQAYKGDHKPAACKAQSSNLSPTIYALPQPPVIPVVDFFKLALQWPPSVCRSTLNCKLPIPTEFKIHGIWAQDAYDIPVPPYDTHHPCTNPQPTILQSKLRKLLKSDVALWNQLPTLWPNLASTGSDIGFWFKEWKKHGTCSDFAQHPLSYFQSAIQLRTNLNPAMGLTRGSTYTVRQVADIVFRLIGASPQISCNRGHPIPLELAKIVPTYFTACAVVNPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V306</accession>
    <name>A0A0D2V306_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G1567002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="18"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="18" mass="2156" checksum="BE2AEC28EA39087A" modified="2015-04-29" version="1" fragment="single">MIGYNWHANSIICTQYEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA42</accession>
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        <recommendedName>
            <fullName evidence="10">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
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    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </comment>
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        <text evidence="8">Belongs to the SFH family.</text>
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        <property type="entry name" value="PI/PC_transfer"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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        </location>
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        </source>
    </evidence>
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        </source>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="B456_010G176900"/>
    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="389" mass="42379" checksum="4F41FA14442A06CF" modified="2015-04-29" version="1">MLACPCSAFNLRATAAPANPDISDPEPEPKVRKLKGSPQFNRWYRARALRSGHKLERPSHGTGALEVNPSAQRTSGTLSLEPTSTANDSDREVELTDSGKPIYMVSDGTGWTAEHSVNAALGQFEHCLVDRGCPVNTHLFSGIDDVERLMEIIKQAAKEGALLVYTLADPSMAESAKQACKLWGIPSTDILGPITEAIAAHLGVSPSGLPRGAAGRNIPLSDEYFRRIEAVEFTIKQDDGALPQNLSKADIVLTGVSRTGKTPLSIYLAQKGYKVANVPIVKGVALPKGLFEVDPEKVFGLTINPLVLQTIRKARAKSLGFGDNARSNYSEMAYVKEELEFARKVFAQNPTWPVIEVTGKAIEETAAVILRLYHDRKQKCSMPRISKRY</sequence>
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        <name type="scientific">Gossypium raimondii</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May promote appropriate targeting of ribosome-nascent polypeptide complexes.</text>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <lineage>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sanders W.S."/>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
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                <person name="Tang H."/>
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                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Lemke C."/>
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                <person name="Reddy U.K."/>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VTV7"/>
    <dbReference type="STRING" id="29730.A0A0D2VTV7"/>
    <dbReference type="Gramene" id="KJB74745">
        <property type="protein sequence ID" value="KJB74745"/>
        <property type="gene ID" value="B456_012G005600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0120">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000057">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000111">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000225">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="248"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="368"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="487"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="31"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB74745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="582" mass="65040" checksum="88893EA5B856B65D" modified="2015-04-29" version="1">MTDCEETRHQGNGDNLENSYGGGSSPQPRSDNQKDSKSQHGSRDYERESSRSREKERERVHDKEREKDRDRHRDRDRDREKDRDRDRHHRDRHRDRSRERSERRDRGRDRDDDDYYRSRDYDRRRDYDRDRKDRPGRSSQSHSRGRSERRSKSRSRSRSRSRSKSKRVSGFDMAPPTSAMLAAGAAAAATCGKFVSKYWCGFGQIPGTSPTLPGVFPSIFPLATTQPFGALPVMPVQAMTQQATRHARRVYVGGLSPTANEQSVATFFSQVMAAIGGNTAGPGDAVVNVYINHEKKFAFVEMRSVEEASNAMALDGIIFEGAPVKVRRPSDYNPSLAATLGPSQPSPNLNLAAVGLTQGTSGGLEGPDRIFVGGLPYYFTEAQIRELLESFGPLRGFDLVKDRETGNSKGYAFCVYQDLSVTDIACAALNGIKMGDKTLTVRRANQGATQPKPEQESILQHAQQQIALQRLILQPQGVPTKVVCLTQALNVDDLMDDEEYEDIVEDMRQEGGKYGELVNVVIPRPNPNGEPSPGVGKVFLEYSDVEGSKKAQVAMNGRKFGGNQVIAVYYPESKFAEREYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WAG8</accession>
    <name>A0A0D2WAG8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_N015600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="KB204215">
        <property type="protein sequence ID" value="KJB84275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WAG8"/>
    <dbReference type="STRING" id="29730.A0A0D2WAG8"/>
    <dbReference type="Gramene" id="KJB84275">
        <property type="protein sequence ID" value="KJB84275"/>
        <property type="gene ID" value="B456_N015600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="288"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LxCxE motif" evidence="3">
        <location>
            <begin position="14"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB84275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="384" mass="44884" checksum="E37613358479FA83" modified="2015-04-29" version="1" fragment="single">MASSFSDTALRLLLSCAEAIEDGDLKSADAFLHNILILADERPFWFGNKKRVVEYFADALVRRAYGLHPASSYFTFPVDPAPYYHYNSYHINGIIKKVIDDALMEKGRLHLIDFSIPYYRFQNSVLRTLPNFFGYPLPVRVSYILPPFLKEYVEFSRQMEFLTKDAEEVDVKLEDELKVVYGNSLAEVDECEIDFKRRRDDEMVVVYYKFKLDKLGRDAKAMERELVRLKEINPTIVIMLDFYSNHTHSNFLTCFKDSLQYSLKTLDYWEALGHNLGWKYGWECNIEAGEGNNIIRRHPSLTEWQHLFSMAGFSRIPLNHRKDNLSFEDNPSFADNSLLEIMGEEEECLILGYKQRPMFFLSAWKPKVEDGHFDSNSTNHKFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M749</accession>
    <name>A0A0D2M749_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G056800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M749"/>
    <dbReference type="STRING" id="29730.A0A0D2M749"/>
    <dbReference type="Gramene" id="KJB13082">
        <property type="protein sequence ID" value="KJB13082"/>
        <property type="gene ID" value="B456_002G056800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055298">
        <property type="entry name" value="AtLOH3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 2-RELATED ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697:SF230">
        <property type="entry name" value="ZINC FINGER, MYM DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="8"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB13082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="269" mass="30962" checksum="1AEA869C8D103FF7" modified="2015-04-29" version="1" fragment="single">KVQSLIRKETGYVKFCLIFDESKEISENKHMAIVVRYVDEQGFVRERFLDLVHVKETTFLTSKFEICVVLSHHNLNLHNLRGQGYDGASKMCEEWNGLQGLTKGVNQIGTIQRLGDTRWSSHYKSLCSLLRMYGATREVLTDIATQGATNDGWEILLQNVKEFCERYGIVISDMHVPYFDLNNRFSEQATELFILSASLNPRDGNKSFNAEHICNLVEKFYPEDFSKQEKDQLKYELQHYGVDVPIHPNLKDLSTLGDLCRGLVTTRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MBB4</accession>
    <name>A0A0D2MBB4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="13">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_002G150800</name>
        <name evidence="16" type="ORF">Gorai_022966</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Extracellular space</location>
            <location evidence="13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="13"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MBB4"/>
    <dbReference type="Gramene" id="KJB14957">
        <property type="protein sequence ID" value="KJB14957"/>
        <property type="gene ID" value="B456_002G150800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785392"/>
    <dbReference type="eggNOG" id="ENOG502R75F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASFMNYN"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080022">
        <property type="term" value="P:primary root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="1 13" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033755230" description="Xyloglucan endotransglucosylase/hydrolase" evidence="13">
        <location>
            <begin position="30"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="14">
        <location>
            <begin position="2"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0580762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="297" mass="33483" checksum="6DB96B8B4476E39C" modified="2015-04-29" version="1">MDTLSSLSNALGMLLITFLMVETFMVASAGNFNKDVDITWGDSRGKILNNGQLLTLSLDKASGSGFQSRNEYLYGKFDMQLKLVPGNSAGTVTAYYLKSQGSSWDEIDFEFLGNLSGDPYVVHTNVYTKGKGGREQQFYLWFDPTADFHTYSILWNPGHVIFYVDGRPIREFKNLESVGIPYPKNQPMRMYCSLWNADDWATRGGLVKTDWSQAPFTASFRNFTANACVLSNGVSSCSSNASSNNAWFSQELDSSSQKVLKWVQKNYMVYNYCKDAKRFPEGLPVECTVRNRKQIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MG99</accession>
    <name>A0A0D2MG99_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G261900</name>
        <name evidence="9" type="ORF">Gorai_023714</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0581538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2MG99"/>
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        <property type="protein sequence ID" value="KJB17037"/>
        <property type="gene ID" value="B456_002G261900"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        </location>
    </feature>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0581538.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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    </protein>
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    <organism evidence="12 13">
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_002G144700"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
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        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF2">
        <property type="entry name" value="SEC12-LIKE PROTEIN 1"/>
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        <property type="entry name" value="WD40 repeat-like"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
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        <location>
            <begin position="244"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB17212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="471" mass="52808" checksum="1E989A3F48270361" modified="2015-04-29" version="1">MLVKQARRGFQNTLLWDPPPKIHNRIRFVSLVPLSLCPAPTLLYFLSQRLLLFINFFFNRSKTQQNFKYLKLKISFISSSMEGEAGGSVSCGSWIRRPENVNWVVLARIMTRPTSSSSSVIEIFPFDPNTTSLSSSPLARHELEESDGDPITIAVHPSGDCFVCSTTNGGCKLFELYGQETHLQLSTKELPPLLDAGPQKCLAFSVDGSRFAAGGVDGRLRILEWPTLRIIVDEVRAHKSFRDMDFSLDSEFLASTSTDGSARIWKTEDGVPLMTLARNSDEKIELCRFSKDGTKPFLFCTVQRGDKAVTAVYDISTWNKIGHKRLLGKPASVMSVSLDGKYLALGSKDGDICVVEVKKMEISHWNKRLHLGTSIASLEFCPSQRVVLTTSSQWGAMVTKLNVPADWKEWQIYLLLLGLFLASAVVFYIFFEKSDSFWNFPIAREQTRRNIDSFLGDAQSDDPNVFGPLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9H3</accession>
    <name>A0A0D2N9H3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G084500</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9H3"/>
    <dbReference type="STRING" id="29730.A0A0D2N9H3"/>
    <dbReference type="Gramene" id="KJB29102">
        <property type="protein sequence ID" value="KJB29102"/>
        <property type="gene ID" value="B456_005G084500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0337">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08147">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="243"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="700"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB29102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="788" mass="89020" checksum="AFE13E18A5C4F487" modified="2015-04-29" version="1">MAPVDERFVSSKAELKRKQKEKKKAKSGGFESLNLSPNVYRGIKRKGYRVPTPIQRKTMPLILAGNDVVAMARTGSGKTAAFLVPMLEKLKQHVPQGGVRALILSPTRDLALQTLKFAKELGKFTDLRISLLVGGDSMESQFEELAQNPDIIIATPGRLMHHLTEVDDMTLRTVEYVVFDEADSLFGMGFAEQLHKILTQLSENRQTLLFSATLPSALAEFAKAGLRDPQLVRLDLETKISPDLKLVFFTLRQEEKHAALLYLARDHISSDQQTLIFVSTKHHVEFLNIMFREEGIEPSVCYGDMDQDARKINISKFRSRKTMLLIVTDVAARGIDIPLLDNVINWDFPPKPKIFVHRVGRAARAGRTGTAFSFVTSEDMPYLLDLHLFLSRPIRAAPTEEEVFQDMDGAMNKIDQAIANGESVYGRFPQNIIDLISDRVRDMIDSSAELNNLQRTCTNAFRLYSKTKPLPARESIKRAKDLPREGLHPIFRNVLEGGELAALAFSERLKAFRPKQTILEAESEAAKSKHSQWVDVMKKKRDMHEKIINLVHKQRFSNHVEKETEPDITSSKINDTKVEARGSKRKARSFKDEEYYISSVPTNHHTEAGLSVRSNEGFGSNRLESAVLDLVADDSEGLQKQKSRYHWDKRGKKYVKLNNGERVTASGKVKTESGAKIKTEKTGIYKKWKERSHKKVYLKGTTNGENGEATTISSGDYRSRGNGRNFRGNKKSQHSVPNAHVRSEIKDFNQVRKERQKKANNKLSYMKGKANKKKGKNFGKSGKRGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NDR9</accession>
    <name>A0A0D2NDR9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G244800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NDR9"/>
    <dbReference type="STRING" id="29730.A0A0D2NDR9"/>
    <dbReference type="Gramene" id="KJB11193">
        <property type="protein sequence ID" value="KJB11193"/>
        <property type="gene ID" value="B456_001G244800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB11193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="8917" checksum="E8CFC834723A7561" modified="2015-04-29" version="1">MGFRLPRIVNAKPSLKRSLSFLETTMVAKGHFVVYVGEHPSFQNCLSQAGVEFGFNHPKGALTISCSEEAFIDLTCNLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NH74</accession>
    <name>A0A0D2NH74_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G227500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NH74"/>
    <dbReference type="STRING" id="29730.A0A0D2NH74"/>
    <dbReference type="Gramene" id="KJB32177">
        <property type="protein sequence ID" value="KJB32177"/>
        <property type="gene ID" value="B456_005G227500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1926">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTESGCF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB32177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="416" mass="47629" checksum="1784CF968322119F" modified="2015-04-29" version="1">MGSKKRIRVKLMEGQTDLATNNTVLVPSNKKITMDNNKEGEMGNGVMEIIKKRKQIDMEKQPKQMNISGLPEFHVSVFKDLASKDSSVRDAALEKIVTELQEVQKEYDRLNDKDNLVDDDGGLKLDAQMDDGLDNCASSLRYAVHHQERMLRQGLDTCFATGFADVRDCLLGWLSAYGALTQSGRLAKEWLSDEDTLHIKEFMSAIIFLSGKKIYLKRKRDRKSKEIAKSVQCFCEIVIEESLLQLSHDSKHLAFDILLLLLPRLPSSFIQIVLSYKVIKCLIDILSTKDSWLYKDGRNFLKELLVWVRNDDIRRAAVIVAFQKHNNGKFDCITKTKTVRDLMAEFKTESGCFLIVENLINLFLNDHASNEPTDQSQTTAMLVVYFDNKKSPIKSGFLKEIFRRHPRIFRRLLGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NML7</accession>
    <name>A0A0D2NML7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G063800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NML7"/>
    <dbReference type="Gramene" id="KJB34392">
        <property type="protein sequence ID" value="KJB34392"/>
        <property type="gene ID" value="B456_006G063800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="134" mass="14469" checksum="F7AC231E26E8CE1B" modified="2015-04-29" version="1">MNLEAVQIKGLWGSGPLQLRNQGLKVMGSFLMCQPKMITTRFNPTLVLNVVCFENFSALSAVGANASGLEPSMQANEFDGIKAHFNATFEGPVGVAVQLSDGVLDPDKHTAVIFKENSHANSHELAEGRKERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NT32</accession>
    <name>A0A0D2NT32_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAR1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G259300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NT32"/>
    <dbReference type="STRING" id="29730.A0A0D2NT32"/>
    <dbReference type="Gramene" id="KJB16993">
        <property type="protein sequence ID" value="KJB16993"/>
        <property type="gene ID" value="B456_002G259300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786516"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="IEYQCRT"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="entry name" value="PAR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33649">
        <property type="entry name" value="PAR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33649:SF4">
        <property type="entry name" value="PAR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06521">
        <property type="entry name" value="PAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265581" description="PAR1 protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19269" checksum="0728C0C3C8C61A30" modified="2015-04-29" version="1">MASLKFPIVLFISSLLLHSSLAEMICEDLPKDVCAFSIASSGKRCVLETAVKKDGDVEYQCRTSEVVVERMAEYIETDECVAACGVDRNSVGISSDSLLDQQFTAKLCTPACYQKCPNIVDLYFNLAAGEGVFLPDLCNAQRSNPRRSMVELMLSSGAAPGPFSGQATAVEAPAPSPMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1V0</accession>
    <name>A0A0D2P1V0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G150700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P1V0"/>
    <dbReference type="SMR" id="A0A0D2P1V0"/>
    <dbReference type="STRING" id="29730.A0A0D2P1V0"/>
    <dbReference type="Gramene" id="KJB20478">
        <property type="protein sequence ID" value="KJB20478"/>
        <property type="gene ID" value="B456_003G150700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789043"/>
    <dbReference type="eggNOG" id="ENOG502QRXJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SNAMPTQ"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="WRKY transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000001">
        <property type="entry name" value="WRKY transcription factor 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF1">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 33-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="234"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="401"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB20478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="573" mass="62666" checksum="0949BBDF8C38D0F6" modified="2015-04-29" version="1">MASSYDTSANSLPQNAFGFSTHPFMTTSFSDLLASGTTDDDNSSSAVNHGKRGGGLSLSDRIAERTGSGVPKFKSLPPPSLPISPPPVSPSSYFAIPAGLSPAELLDSPVLLNSSNILPSPTTGTFPAQAFNWKPSSGNNQQNVKRVDKSYTDFSFQTFQSSTNTNQTAQQEAWSFKESVKEADFSSGKNMVKSEYNQMQSFSPEIANIQSCQSDYTNYQHQQSQSLRGNRKSDDGYNWRKYGQKQVKGSENPRSYYKCTYPNCPTKKKVERSLDGQITEIVYKGSHNHPKPQSTRRSSSSSSSSIAIQASSAATSEIPDHSFISHGSGHMDSAATPENSSISVGDDDFDRGSQKSKSGGDEFDEDEPDAKRWRGEGETEGISAPGSRTVREPRVVVQTTSDIDILDDGYRWRKYGQKVVKGNPNPRSYYKCTHPGCPVRKHVERASHDLKAVITTYEGKHNHDVPAARGSGGHSVNRPLPDNNNNNGAMAIRPSPLNNPMSNNQALRGLRQSTTEGESPFMLEMFQGNGNLGFSGFGNSGGSIMNQQHDVHNMFSRTKEEPRDEAFIESLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PHQ6</accession>
    <name>A0A0D2PHQ6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G243400</name>
        <name evidence="11" type="ORF">Gorai_015481</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PHQ6"/>
    <dbReference type="Gramene" id="KJB26453">
        <property type="protein sequence ID" value="KJB26453"/>
        <property type="gene ID" value="B456_004G243400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792548"/>
    <dbReference type="eggNOG" id="ENOG502QPJU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEVEATM"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000578">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000565">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF276">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="9">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB26453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0584680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="548" mass="59440" checksum="46E7761A5001FF63" modified="2015-04-29" version="1">MGGNGKHRWIFSFYKRSNSSSSPKQSKTLPPREFLCPISGSLMFDPVVIPSGQSFDRISIQVCRDLGFTPTLQDGSTPDFSTIIPNLAIKTTILAWCRDQHAQDPAPPDYSSVEKIVLSKIPEQTSSRLTSGPDIRVSERELLKAVAENPPVLFSHAATEIGPSVNSRLLCSTSTSSSSDESVIVTASSPYTPLPLSTRPACFSASGSSSSSTEITLSETPNLKSQSSSSLEEQELVLKLKSSDIFEQETGLVLLRKITRTKEEARVSLCSPRLLSALRSLITSRYSVVQTNAIASLVNLSLEKSNKVVIVRSGFVPLLIDALKAGSSEAQEHAAGALFSLALEEENKMAIGVLGALQPLLHALRSESERTQHDSALALYHLSLIQSNRVKLVKLGAVLTLLSMVKSGDSASRVLLVLCNLAACPEGKSAMLDANAVAILVGMLRESELVCKATRENCVAALFALSHGSMRFKGLAKEARAVEVLREVEERGSERAKDKAKRILQIMKDRKEDEDDEIDWEAALESDGLSRTRYRVGKDDFAANSTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PQD8</accession>
    <name>A0A0D2PQD8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G121900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PQD8"/>
    <dbReference type="STRING" id="29730.A0A0D2PQD8"/>
    <dbReference type="Gramene" id="KJB09056">
        <property type="protein sequence ID" value="KJB09056"/>
        <property type="gene ID" value="B456_001G121900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB09059">
        <property type="protein sequence ID" value="KJB09059"/>
        <property type="gene ID" value="B456_001G121900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000270">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF21">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="74"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB09059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="348" mass="39714" checksum="9303CE23E36DC486" modified="2015-04-29" version="1">MVFSPFAAMIAPIAVALTVGLLGWTYRALKPPPPKICGSPDGPPVTSPRIKLSDGRHLAYREAGVPREEAKYKIVVIHGFGSSKDLNLPASEELVEELRIYFLFFDRSGYGDSDPNPSRSVKSEAYDVQELADKLQIGSKFYVIGISMGAYPVYSCLKYIPHRLAGASLVAPFVNYWWPCLPANLSNDAFSRLLAQDQWSFRVAHYTPWLFYWWMSQKWFPSLSILAGNMAIFSQSDLEILKKWSEAPSVGQEKIQQQGVYESLHRDIMVSYGKWEFDPMDLINPFPNNEGSVYIWQGYEDRIIPFQVNRYLSEKLPWINYHEVPDAGHLLIFESKNCEAVLRELVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYD6</accession>
    <name>A0A0D2PYD6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G133500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYD6"/>
    <dbReference type="STRING" id="29730.A0A0D2PYD6"/>
    <dbReference type="Gramene" id="KJB09296">
        <property type="protein sequence ID" value="KJB09296"/>
        <property type="gene ID" value="B456_001G133500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793810"/>
    <dbReference type="eggNOG" id="KOG0066">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARLVLCM"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000792">
        <property type="entry name" value="ABC transporter F family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001124">
        <property type="entry name" value="ABC transporter F family member 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="158"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="489"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="716" mass="79888" checksum="59819BA0B609AF77" modified="2015-04-29" version="1">MGKKKQEESGAAAKVKGGSKDVKKEKLSVSAMLASMDQKPEKPKKATSTKPKAKGPKVSSYTDGIDLPPSDEEDEFPSGEEQTQSNRQERQSLKPLDTSISEKELKKREKKEMLATQAAELAKQEALKDDHDAFTVVIGSRASVLDGEDDADANVKDITIDNFSVSARGKELLKNASVKISHGKRYGLVGPNGMGKSTLLKLLAWRKIPVPKNIDVLLVEQEVVGDDRTALQAVVSANEELIRLREEVAALQNSSASNGEDENDLNGDDAGERLAELYEKLQILGSDAAEAQASKILAGLGFTKAMQGRPTRSFSGGWRMRISLARALFVQPTLLLLDEPTNHLDLRAVLWLEEYLYRWKKTLVVVSHDRDFLNTVCTEIIHLHDMKLQFYRGNFDDFESGYEQRRKEMNKKFEIYEKQVKAAKRSGNRVQQEKVKDRAKFAAAKEAAKNKGKGKIDEDDRPAEAPKKWRDYSVEFHFPEPTELTPPLLQIMNVSFSYPNREDFRLSDVDLGIDMGTRVAIVGPNGAGKSTLLNLIAGDLVPTEGEVRRSQKLRIGRYSQHFVDLLTMEETPVQYLLRLHPDQEGLSKQEAVRAKLGKFGLPSHNHLTPIAKLSGGQKARVVFTSISMSKPHILLLDEPTNHLDMQSIDALADALDEFTGGVVLVSHDSRLISRVCEDEEKSQIWVVDNGTVNTFPGTFEDYKDELQREIRAEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYE1</accession>
    <name>A0A0D2PYE1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G2364001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYE1"/>
    <dbReference type="Gramene" id="KJB32338">
        <property type="protein sequence ID" value="KJB32338"/>
        <property type="gene ID" value="B456_005G2364001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32339">
        <property type="protein sequence ID" value="KJB32339"/>
        <property type="gene ID" value="B456_005G2364001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="41" mass="4686" checksum="B7E9939A7C9B052F" modified="2015-04-29" version="1" fragment="single">MHHWLVAVGTPRKNKQQTHPLMSRPFLTFLSLSKSPVSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZB5</accession>
    <name>A0A0D2PZB5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-specific lipid-transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G155200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZB5"/>
    <dbReference type="STRING" id="29730.A0A0D2PZB5"/>
    <dbReference type="Gramene" id="KJB09616">
        <property type="protein sequence ID" value="KJB09616"/>
        <property type="gene ID" value="B456_001G155200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795991"/>
    <dbReference type="eggNOG" id="ENOG502S7TU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICECLVN"/>
    <dbReference type="OrthoDB" id="1862539at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000528">
        <property type="entry name" value="Plant_nsLTP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33076">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00234">
        <property type="entry name" value="Tryp_alpha_amyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00382">
        <property type="entry name" value="LIPIDTRNSFER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249882" description="Non-specific lipid-transfer protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB09616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="126" mass="13313" checksum="417B793E10958D55" modified="2015-04-29" version="1">MTRSFNFLPLLLLLTLSALTVQEISAAPSCTEVAIELLPCLSFLSGNGAADVPSRACCLGAQTIAYEAQTKDDRRAICECLVNALANIGTSDSFTARIPLIATQCGVDVSLPPITGDKDYCSKLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q699</accession>
    <name>A0A0D2Q699_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G010500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q699"/>
    <dbReference type="STRING" id="29730.A0A0D2Q699"/>
    <dbReference type="Gramene" id="KJB12301">
        <property type="protein sequence ID" value="KJB12301"/>
        <property type="gene ID" value="B456_002G010500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1310">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045151">
        <property type="entry name" value="DCAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="106" mass="11846" checksum="20BD7E85ADBBBFFE" modified="2015-04-29" version="1">MTRCSRSGILVFDIVQLSQQLDLRYGAKRSLADPPRLTLALKSCDISSTRPHFLLVGGNDAFARLYDRRMLPPLTSCQKRMLPPTCVTQCISPTVLVLKLFVSSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q6M3</accession>
    <name>A0A0D2Q6M3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Cellulose synthase</fullName>
            <ecNumber evidence="22">2.4.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B456_009G010200</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 22">
            <text>[(1-&gt;4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19929"/>
            <dbReference type="Rhea" id="RHEA-COMP:10033"/>
            <dbReference type="Rhea" id="RHEA-COMP:10034"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 22">Glycan metabolism; plant cellulose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 22">Cell membrane</location>
            <topology evidence="2 22">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="22"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q6M3"/>
    <dbReference type="STRING" id="29730.A0A0D2Q6M3"/>
    <dbReference type="Gramene" id="KJB53892">
        <property type="protein sequence ID" value="KJB53892"/>
        <property type="gene ID" value="B456_009G010200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767346"/>
    <dbReference type="eggNOG" id="ENOG502QQJD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MHTRGWI"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="UniPathway" id="UPA00695"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16617">
        <property type="entry name" value="mRING-HC-C4C4_CesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000031">
        <property type="entry name" value="Cellulose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000009">
        <property type="entry name" value="Cellulose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027934">
        <property type="entry name" value="CES_Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13301">
        <property type="entry name" value="X-BOX TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14569">
        <property type="entry name" value="zf-UDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 22" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 22" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 22" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="6 22" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="859"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="980"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1009"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="1043"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="domain" description="Cellulose synthase RING-type zinc finger" evidence="24">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="126"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="782"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="538"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU361116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF14569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJB53892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121845" checksum="32582DC069902943" modified="2015-04-29" version="1">MEASAGMVAGSHRTNQLVRIRHDSDSGPKPLKNLNGQTCQICGDNVGVGAAGDVFVACNECAFPVCRPCYEYERKDGTQCCPQCKTRYKRQKGSPRVEGDDDEEDVDDLENEFDYAQGLSKARRQWQGEDVDLSSSSRHESQQPIPLLTNGHTVSGEIATPDNRSVRTTSGPLGPSEKNGSSSPYVDPRQPVPVRIVDPTKDLNSYGLGNVDWKERVESWKLKQEKNVMHMNNRYPEGKGDIEGTGSNGEELQMADDARQPLSRVVPISSSHLTPYRVVIILRLIILGFFLQYRATHPVKDAYPLWLTSVICEIWFALSWLLDQFPKWYPINRETYLDRLALRYDRDGEPSQLSPVDVFVSTVDPLKEPPLVTANTVLSILAVDYPVDKVACYVSDDGSAMLTFEALSETAEFARKWVPFCKKHSIEPRAPEFYFAQKIDYLKDKIKPSFVKERRAMKREYEEFKVRINALVAKAQKMPEEGWTMQDGTPWPGNNPRDHPGMIQVFLGHSGGLDTDGNELPRLIYVSREKRPGFQHHKKAGAMNALIRVSAVLTNGAYLLNVDCDHYFNNSKALKEAMCFMMDPAYGRKTCYVQFPQRFDGIDLHDRYANRNIVFFDINLKGLDGIQGPVYVGTGCCFNRQALYGYDPVLTEADLEPNIIVKSCCGSRKKGKSGNKKYIDKKRAAKRTESTIPIFNMEDIEEGVEGYEEERSLLMSQKRLEKRFGQSPVFIAATFMEQGGIPPSTNPATLLKEAIHVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHARGWISIYCMPPRPAFKGSAPINLSDRLNQVLRWALGSIEILLSRHCPIWYGYKGRLRLLERLAYINTIVYPLTSIPLLAYCMLPAFCLLTGKFIIPEISNFASMWFILLFVSIFATGILELRWSGVSIEDWWRNEQFWVIGGTSAHLFAVFQGLLKVLAGIDTNFTVTSKASDDDGDFAELYVFKWTSLLIPPTTVLIINLVGIVAGVSYAINSGYQSWGPLFGKLFFAIWVIAHLYPFLKGLVGRQNRTPTIVIVWSILLASIFSLLWVRIDPFTSEATKAAANGQCGINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q6S2</accession>
    <name>A0A0D2Q6S2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_006G097400</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q6S2"/>
    <dbReference type="STRING" id="29730.A0A0D2Q6S2"/>
    <dbReference type="Gramene" id="KJB35048">
        <property type="protein sequence ID" value="KJB35048"/>
        <property type="gene ID" value="B456_006G097400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEENGHW"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF46">
        <property type="entry name" value="SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="19">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="19">
        <location>
            <begin position="153"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB35048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="248" mass="27121" checksum="7DC06B4DE7AF485A" modified="2015-04-29" version="1">MENDSLQTSLAWLRDILQGKIGHGLDTRVLQGLRVIHAEKGFMRFDFVVPKSVSDIDGNWNVGALASLVDLLGGVTIFSFANRVVTSVDFSVSYYSTAKIQEHVEIESKVSADKGNLIHVVVEVKRKGNGEVIAVGKLWMASNKLSVAQDVDGNWHVGALASLLDLIGIVTIYSFANRVISTVDFNASYYSTAKIQEHVEIESKVTANRGKLLHVVIEVRRKGNGEVIAVGKQWMASNKQTLAQVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q928</accession>
    <name>A0A0D2Q928_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G072200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q928"/>
    <dbReference type="STRING" id="29730.A0A0D2Q928"/>
    <dbReference type="Gramene" id="KJB13391">
        <property type="protein sequence ID" value="KJB13391"/>
        <property type="gene ID" value="B456_002G072200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779238"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SQRKCRD"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF14">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="632"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="697" mass="78424" checksum="399B7E59793A1602" modified="2015-04-29" version="1">MRGPLGAVLERYPLSDGTTEDGGIIRHNRKCRDVAFLVIFIAFWVAMIVNSSFGFNQGNPLRLTYGLDYKGNVCGDKHAHPGLHQLELKYWLNPNQVYQSGVKDSQFKLSNARSICLLDCPTPLEDSLSWVCDYPEGDIHLSMDDWIDRNYDYYEILTPEMKNASLQLQGPCYPVIFPSVNVYWSCQYIARASNASLRHWKQMGGVDIKEDIVVDKSIHSFINSRSSVLKRYMADIGKAWPVLIVCGGLLPLFLSVVWLLMIRYFVAAMPWITVAFFNILIITVTVFYYLKAGWIGNDAISPIIGDHDPYIHVFGRELNHLRAAAILMTFVMVLSILTSIAIVRRILMGTSVLKVAAKVIGEVQALIIFPVIPYSILAIFYMVWISAALHLFSSGQVVQNNCNTNCCAYDLLSEKVNCDHCCGYSIRYTPHIAVAIFFHLFGCYWATKFFIACSSTVIAGSVASYYWTRGETSSEVPVLPVFDSMKRLIRYSLGSVALGSLIVSFVESIRFILESFRRKLKVTETTPDSWFGKMVYHTSQGCLRCVEWTIKSVNRNAYIMIAITGKSFCRSSAIATELIMNNILRLVRLNVIGDVILFLGKLFVSLSSAVFGFLVLDTHKYSSGHNKLSSPLLPVLVCWTLGYVVATLFFAVVEMSIDTLILSFCQDSEEHEGTAQFAPLLLMETLNEQNDMQRLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QC07</accession>
    <name>A0A0D2QC07_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G087800</name>
        <name evidence="2" type="ORF">Gorai_011415</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QC07"/>
    <dbReference type="Gramene" id="KJB55657">
        <property type="protein sequence ID" value="KJB55657"/>
        <property type="gene ID" value="B456_009G087800"/>
    </dbReference>
    <dbReference type="OMA" id="HEEHFFQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB55657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0594512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="163" mass="18493" checksum="13CCA11E9FDD66EB" modified="2015-04-29" version="1">MSNPWCNDGKSPQNPCNSNTVFENSPDLLLGWFKNLNAQHKQELIIELSTKVQGLSMEKQLPTERAEVDDDLKARHFQQLLQRLSSKKNNVGSKIHKAYLGVQRRYIIEHEDQHLLKPDKLSNLKSIDSRAGSPVVRKEGAISEVGSSLNPELFKIKKFSTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QD30</accession>
    <name>A0A0D2QD30_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized protein ycf72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G146700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ycf72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QD30"/>
    <dbReference type="STRING" id="29730.A0A0D2QD30"/>
    <dbReference type="Gramene" id="KJB14861">
        <property type="protein sequence ID" value="KJB14861"/>
        <property type="gene ID" value="B456_002G146700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S62T">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIPWERS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038860">
        <property type="entry name" value="YCF72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37377">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37377:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="135" mass="15067" checksum="ED8650FBAED65D93" modified="2015-04-29" version="1" fragment="single">SPPFTIPWERSTGFITTPLTTGHLPSQHLDPTLPKLFWFTPTFPTCPTVAEQFLDIKWTSPEGYFNVANFPSFVISFATAPAALVNCPPLPSVISILCMAVLKGISVEVDSFLIDQSKPLPKLYKLLPKHMTFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QD78</accession>
    <name>A0A0D2QD78_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G194400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QD78"/>
    <dbReference type="STRING" id="29730.A0A0D2QD78"/>
    <dbReference type="Gramene" id="KJB37223">
        <property type="protein sequence ID" value="KJB37223"/>
        <property type="gene ID" value="B456_006G194400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800082"/>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIVFITQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF29">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB37223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="191" mass="21967" checksum="6922A1C383ADC91D" modified="2015-04-29" version="1">MYTSMKKIHKDKDVEPTEFEESVAQAFFDLENTNQDLKSDLKDLYINSAVQIDVSGSRKAVVIHVPYRLRKAFRKVHVKLVRELEKKFSGKDVILIATRRILRPPKKGSAVQRPRSRTLTAVHEAMLEDIVLPAEIVGKRTRYAIDGSKLMKVFLDPKERNNTEYKLETFSAVYRKLAGKDVVFEFPVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QDC5</accession>
    <name>A0A0D2QDC5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G150700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QDC5"/>
    <dbReference type="Gramene" id="KJB14956">
        <property type="protein sequence ID" value="KJB14956"/>
        <property type="gene ID" value="B456_002G150700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785391"/>
    <dbReference type="eggNOG" id="ENOG502QW53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1718296at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="8"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="185"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="361" mass="39225" checksum="02D71BC3DCFBD0B1" modified="2015-04-29" version="1">MGSKKPFLVALLVHALSSGMILLSKAVFNMGMNISVFVFYRQVAGTIFMVPFAMVFEGKHAKPLSILTFFKIFMLASLGITLTLNIYGVALIYTSASLGAATINCIPVITFAFAVLLRMEKVRVKTVPGIAKVAGIVVCMAGVVTLAFYKGPALKPPFHLHNFRPHSGAQDGDHDHASSAKNWIIGCFLLLASCICWALWLVLQAHILKSYPSKLTFTSIQCLSSAVQSFIVAIALERDPRQWKLGWNFRLLAVVYCGIFVTGVAYYLQAWVIAKKGPVFHAVMIPSNLIMTSLGSVFLLGETINLGSVLGAIMLVISLYSVLWGKSKEQNVDNVGCLPVENQTQVKETAVSSSPRTSLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEW8</accession>
    <name>A0A0D2QEW8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G223200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEW8"/>
    <dbReference type="STRING" id="29730.A0A0D2QEW8"/>
    <dbReference type="Gramene" id="KJB37848">
        <property type="protein sequence ID" value="KJB37848"/>
        <property type="gene ID" value="B456_006G223200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37849">
        <property type="protein sequence ID" value="KJB37849"/>
        <property type="gene ID" value="B456_006G223200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37850">
        <property type="protein sequence ID" value="KJB37850"/>
        <property type="gene ID" value="B456_006G223200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800380"/>
    <dbReference type="eggNOG" id="ENOG502QV0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FINAVHI"/>
    <dbReference type="OrthoDB" id="770239at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022212">
        <property type="entry name" value="DUF3741"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212">
        <property type="entry name" value="ADHESIN-LIKE PROTEIN, PUTATIVE (DUF3741)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212:SF4">
        <property type="entry name" value="ADHESIN-LIKE PROTEIN, PUTATIVE (DUF3741)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12552">
        <property type="entry name" value="DUF3741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="2">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="3">
        <location>
            <begin position="730"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB37848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="898" mass="101561" checksum="75967B6BA4E9A651" modified="2015-04-29" version="1">MAKRSNRRPVRNEKERLGCMWGLISMFDFRNGRSTQRLLSDRRQGNKKAAVGTGNLGNKLDMLTSSGEKCPRTRDGEEKAKVVNACNPSVKKLLEEEMSGKQVVKNEVNNTEFEAKQFDSVQGDDGRKNRKRKNKTRKKSSGTSLDIDAAENLLSEVSCQDKSEQPQPTSSLDMDSLMKEFSRQIHRKRINCVNHDQPAEDHMQPNPKSSCFEERLSEVIKFLVSQKLIDKNQLTDDGELQASKEVMDVLRISSLDEELFLKLLRDPNSLVKYVRNMPDSQLKDEESKPRAVSKFPDNIHVGLRQLNEPVNTKQRNFFRRKSKSQDGNNISEASSKIVILKPGPITSETGSSFGSSPESRYTIRHKEPNEKVGSHYFLSEIKRKWKHAMGREQQRNPTDGISGRLSSEQQRSGNNGGVKEHIGMSSPTKDHFFIERIARPSFGVKKGEKPSKLKGFELGTESETTDFSQHYNLYIEAKKHLSEMILNGDKNVDLSCQKVSKSLGRILSLPEYNLSPFGSPRRNSESSFTTAQMRFTGCDKFQNVNENDQQNYVSHLSQVTAEEPESQLCFSDDKASDEVQGGVNIVEDDNMVLGESKQSDASFETSGSSISRDDDTPKVCIEQQYPECLKEDSSEVDHQLFSPLESPPNSLVTKKVEGLESVNDTQERPSPVSVLEPIFTDDVISPSSIRSRSGETTIQPLRIRFEEHGSIAANQSNCIKTCVDDEESIFDHVKALLQPSTFNWDELYIRSLSSELLLDPMLLDEVEYFPNQLCNDQKLLFDCINEVLMEVCGYYYSSLGVSFVKPKIRPIPNTKNTIQKVWEGVHWHLLPMPLPRTLDQIVRKDVAKTETWMDLRLDTDCIGFEMGEVILEDLVEDTITGYMSEALGGECNAEELHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QG25</accession>
    <name>A0A0D2QG25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G201600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QG25"/>
    <dbReference type="Gramene" id="KJB15886">
        <property type="protein sequence ID" value="KJB15886"/>
        <property type="gene ID" value="B456_002G201600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785948"/>
    <dbReference type="eggNOG" id="KOG4732">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RGGFWKY"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055326">
        <property type="entry name" value="MINIYO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47605">
        <property type="entry name" value="TRANSCRIPTIONAL ELONGATION REGULATOR MINIYO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47605:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ELONGATION REGULATOR MINIYO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="293"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="416"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1400"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1616" mass="180934" checksum="847E0807C274991B" modified="2015-04-29" version="1">MEKKQEQRSGHKTKRNEGKVASLKVFGSSSINGDDASSLVGSIIEKGIVSNNDISKPIQPPRLSVLPFPVARHRSHGPHWTPRSDNRNVVEEDDEDETGFANFDPISVFAEPIRRKEKKNLDLSHWKEAMQGDDLSQRKGRETNQSGVGKTERQMMDGKAMKDLGNKSMLINSFGAHADVASMDVESHLNAHRPLAKAEEAMRSELSDSSVTGMDLDDSLQLQKEEHVKDHDSETFSKESGTMAVDGQVMAKRMCHNDSTNVEFRRMENIDTMVPEQFCNLGNERGSMSLESEIDAENRARLENMSPEEIKEAQAEIMLKMDPALLNLLKKRGQEKLKKQIDTHSNQAAESQLGIRRENQSNNAMKAPNLDSNNPTVTTSSNITKSGLDNGVKQNVDSASGSLWDAWSQRVEAVRELRFSLDGTVVENDFVQIPEIRGDNVAERDFLRTEGDPGALGYTIKEAVALTRSTIPGQRALALHLLASVLDKALRNIYLNPIGSTLADKDNVDSTVDWEAVWAFALGPEPELILSLRMSLDDNHNSVVLATAKVIQCVLSCDINQSFFDLLEKTAIDMRGTYTAPIFRSKPEIDVGFLHGGFWKYSAKPSNVLLYGDNIVEDETEGKHTIQDDIVVAGQDFAAGLVRMGILPRIRYLLEIEPTAPLEECLISVLVAIARHSPMGVNAIMKCQRLVQTVVHRFTANSNMDVYLSKIKSVCLLKVLAQSDRKNCAEFVENGIFQAMTWQLYKNAYSLEQWLKLGRENCKLSSALMVEQLRFWKVCIQYGYCVSYFSNILPALYLWLNPPTIRKLVENNVLGEFASISVEAYLILESLARTLPNFYSHKILSDGIAEGADDNVETWSWSHARPMVDLALKWISFKSRLIDSQDEIIGISIFHDKSSSPLLWVYSAVMHMLSRVLEKVIPEDAMGLQDDGHVPWLPDFVPKVGLEIIRNGFLSFTRVNTAEYGANLAAGSFFIEQLCSLRKQSAFETSFASLCCLHGFFQVFIYINNLIQLAKPVVCNPSQACSLSQEENILSKGILVESLFELRCVFDIFSKLVASEWHLVQSVEIFGRGGPAPGVGLGWGASGGGFWSKSVLLAQTDAWLLSLLLDIFQTVSIEVLSLDYERTFTREIIFSALGLCLISGPRDKVIVEKALDVMLQVPVLKYLDLCIQHFIQGNGRIKLYGWEYKEDDYMLFSEILASHFRNRWLSNKNKLKASSVDRTSRSNASLETIPEDLDTSMMSRDNNCTSLMMEWAHQRLPFPVHWFLSPISTLCDSKHAGLGRVSDIQNIVQDPGDIVEVSKAGMFFLLGLEALSTFLSADVVSPIRSVPVIWKLHSLSIILLIGMAVLEDEKTRDVYESLQELYGQLLDEIRSKGRSQTISNMSTSLTPETENKINVEFLRFQSEIHESYSTFIDTLVEQYAAVSFGDLTYGRQVAIYLHRCVEAPVRLAAWNALSNSHVLELLPPLQKCLAEAEGYLEPVEENEAILEAYVKSWVSGALDKAATRGSVAFTLVLHHLSTFVFISHKSYKPLLRNKLVKSLLRDYARKKQHEGMMLQFIEYTKPSSVTKAEKEEGLTMESSNVEGRLERLKEACEGNPSLLTLVDKLKSSCLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QID6</accession>
    <name>A0A0D2QID6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G066900</name>
        <name evidence="4" type="ORF">Gorai_020680</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QID6"/>
    <dbReference type="Gramene" id="KJB06974">
        <property type="protein sequence ID" value="KJB06974"/>
        <property type="gene ID" value="B456_001G066900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB06975">
        <property type="protein sequence ID" value="KJB06975"/>
        <property type="gene ID" value="B456_001G066900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB06976">
        <property type="protein sequence ID" value="KJB06976"/>
        <property type="gene ID" value="B456_001G066900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786963"/>
    <dbReference type="eggNOG" id="KOG4374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETNACID"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF65">
        <property type="entry name" value="SAM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="229"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB06975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0578397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="291" mass="32995" checksum="2E982B85E3F1C830" modified="2015-04-29" version="1">MLVLSMNSKRQRRPNVRLGEIGDASAAFACGFSQKTKENLVHKRWKPDFLNSQVNEPVTVDEFSKGKSPDFLNLDPGFLPADLQQNRENKNPNSSKLGFDLVTADEIDMMKSSINFGTITRKSRVMKRRGRIREGNNSAFLCSAWTQSPKFSPEFSGEDRKEHDDEEKEFMGIESNACIDSQYLSDHDADEPDSWQQGNADDCYEDNALLRSGDEWDQTRYACNDVTGVRTWLEDLGFGRYAGIFEMHEVDQETLPLLTLDDLKEMGVFAVGHRRKLYTAIQQLRGGNASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJI5</accession>
    <name>A0A0D2QJI5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G262100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJI5"/>
    <dbReference type="STRING" id="29730.A0A0D2QJI5"/>
    <dbReference type="Gramene" id="KJB17041">
        <property type="protein sequence ID" value="KJB17041"/>
        <property type="gene ID" value="B456_002G262100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786542"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARKFWII"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="9">
        <location>
            <begin position="46"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB17041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="483" mass="54491" checksum="5041BFB20B9FBE22" modified="2015-04-29" version="1">MLGQKQSEEAIVSNYNESEQHHVENRDEEKEEENQSLFNVKNLLWHGGSAWDAWFSCASNQVAQVLLTLPYSFSQLGMLSGILLQVFYGIIGSWTAYLISVLYIEYRSRKEKENVNFKNHVIQWFEVLDGLLGPYWKALGLAFNCTFLLFGSVIQLIGCASNIYYVNDKLDKRTWTYIFGACCATTVFIPSFHNYRIWSFLGLGMTTYTAWYLAIAALVHGQAEGVTHSGPTKLVLYFTGATNILYTFGGHAVTVEIMHAMWKPQKFKYIYLLATLYVFTLTLPSAAAVYWAFGDELLNHSNAFSLLPKNGFRDAAVILMLIHQFITFGFACTPLYFVWEKVIGMHDTKSICLRALARLPVVIPIWFLAIIFPFFGPINSAVGALLVSFTVYIIPALAHMLTYRKASARQNAAEKPPFFMPSWTGMYALNAFIVVWVLVIGFGFGGWASMTNFIRQIDSFGLFAKCYQCKPPTPTSPAAAMHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKB0</accession>
    <name>A0A0D2QKB0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="2">HIB-CoA hydrolase</shortName>
            <shortName evidence="2">HIBYL-CoA-H</shortName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G038000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QKB0"/>
    <dbReference type="STRING" id="29730.A0A0D2QKB0"/>
    <dbReference type="Gramene" id="KJB07695">
        <property type="protein sequence ID" value="KJB07695"/>
        <property type="gene ID" value="B456_001G038000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774505"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TESCDEW"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000027">
        <property type="entry name" value="Probable 3-hydroxyisobutyryl-CoA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF14">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB07695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="405" mass="45733" checksum="E378B4A302062B6F" modified="2015-04-29" version="1">MQRVKALIKVRHSFQTLRFLSHQRCFSAQPNYAPYNDFQDQVLVEGRAKSRAAILNRPFALNSLTTSMASRLKKLYESWEENPDIGFVIMKGNGRAFCSGVDAVALYHLLNEGKVEDCKRFFETLYKFVYLQGTYLKPHVAILDGITMGCGGGISLPGMFHLVTDKSVFAHPEAQLGFHPDSGASFYLSRLPGYLGECLALTGEKLNGVEMIACGLATHYCLNARLSWVEECLGNMMNDDPTVIESSLAQYGDLVYPDRSSILHRIETIDKCFCHDTIEEIIDSLENEAAGAYDDWCRTVLRKMKEASPLSLKVTLRSIREGRFQSLDQCLAREYRMSLAAISKQVSNDFSEGVRARLVDKDFAPKWDPPRVEEVSKDMVEYYFTPLGELEPELLLPTALREPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QL61</accession>
    <name>A0A0D2QL61_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G006500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QL61"/>
    <dbReference type="STRING" id="29730.A0A0D2QL61"/>
    <dbReference type="Gramene" id="KJB17591">
        <property type="protein sequence ID" value="KJB17591"/>
        <property type="gene ID" value="B456_003G006500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000014">
        <property type="entry name" value="Aspartyl protease family protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF826">
        <property type="entry name" value="ASPARTYL PROTEASE FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="497"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB17591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="547" mass="59306" checksum="7A18EC06C5375A5E" modified="2015-04-29" version="1">MSEFTRYSRVLLLMVLGLSAGACYGFGTFGFEFHHRYSDPVKQILAVDELPAKGSLEYYSAMIHRDKIIKGRRLAAENDQTPVTFLDGNATYRLNSLGYLHYANVTVGTPALWFLVALDTGSDLFWLPCDCSSCVHGIRSPGGPTIEFNIYSPNTSSTSSKVPCSSDKCEQHRKCSSPTNTCPYQVIYLSNGTSSIGVLVEDVLRLTTDDDKTNKPVEAKITFGFVSFTSFVLKSHLAVVENSIGLSSTRHAFCGKIQTGSFLNGAAPNGLFGLGMDNISVPSILAKENVTSNSFSMCFRSDGIGRITFGDKGSSDQGETPINPRQSRPTYNISITQISVGGKTGDLEFDAVFDSGTSFTYLNDPAYTLISETFNNLALDKRHTSKSTDDLPFEYCYDLSANQTSLKYPVVNLTMKGGDQLLVNDPIAVLPMQGGAIYCLAVVKSDSVNIIGQNFMTGYRIVFDREKMVLGWKASDCYNIESSNTLPVIPPSAVPPATAVKPEATARNSSNAGAPGSSPPPMTNKSTQHKALSYVFTIALVLYFALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLI4</accession>
    <name>A0A0D2QLI4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G046500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLI4"/>
    <dbReference type="SMR" id="A0A0D2QLI4"/>
    <dbReference type="STRING" id="29730.A0A0D2QLI4"/>
    <dbReference type="Gramene" id="KJB40093">
        <property type="protein sequence ID" value="KJB40093"/>
        <property type="gene ID" value="B456_007G046500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802148"/>
    <dbReference type="eggNOG" id="KOG1678">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WITKAVY"/>
    <dbReference type="OrthoDB" id="1579981at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF20">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB40093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="204" mass="24259" checksum="8F0EC1B592CA2BEB" modified="2015-04-29" version="1">MGAYKYVSELWRKKQSDVMRFLQRVRCWEYRQHPSIVRVNHPTRPDKARRLGYKAKQGYVVYRVRVRRGGRKRPVPKGIVYGKPTNQGVTQLKFQRSKRSVAEERAGRKLGGLRVVNSYWINEDSTYKYFEVILVDTAHNAIRNDPRINWICNPVHKHRELRGLTSAGKKYRGLRGKGHLHHKARPSRRANWKRNNTLSLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QM13</accession>
    <name>A0A0D2QM13_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G056000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QM13"/>
    <dbReference type="STRING" id="29730.A0A0D2QM13"/>
    <dbReference type="Gramene" id="KJB40298">
        <property type="protein sequence ID" value="KJB40298"/>
        <property type="gene ID" value="B456_007G056000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802236"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000025">
        <property type="entry name" value="Aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000030">
        <property type="entry name" value="Eukaryotic aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF817">
        <property type="entry name" value="OS07G0592200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">8</strain>
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        </source>
    </reference>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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            <begin position="25"/>
            <end position="38"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QUH5</accession>
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    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001746">
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    <dbReference type="STRING" id="29730.A0A0D2QUH5"/>
    <dbReference type="Gramene" id="KJB42868">
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        <property type="gene ID" value="B456_007G171400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803466"/>
    <dbReference type="eggNOG" id="KOG0701">
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    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0005737">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000004">
        <property type="entry name" value="Endoribonuclease dicer-like 1"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
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        <property type="entry name" value="dsRBD_dom"/>
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    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
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    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
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        <property type="entry name" value="DICER-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF54">
        <property type="entry name" value="RNASE II-LIKE 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNASE_3_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB42868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0590212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="278" mass="31849" checksum="9341E9F14E80F1FE" modified="2015-04-29" version="1">MTAITIKALKEQQHIIQQQSESAGESTQSLPSLDEVEQILGYEFNNKRLLEEAFTHASLGLGFSNERLEYVGDSVLNLLFTKQQFFEYPDLPPGPLTRLRAANVDTEKLARAAVKHGLHRYLRHKKPLLKEQIRQFSEEIQRYPLHSNGLVDVPKALADLVESTIGAVFIDTNSLHVVWKVFKDLLEPIIRRETLKIHPVTQLYEVCQKRNLKVKFVDLWKESTGFDVFVDDQLVGRGKCSLKKEIAHNRAAKDALDNILRILDEKDTNINIVEERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QUQ7</accession>
    <name>A0A0D2QUQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Photosystem II D2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_001G234300</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the reaction center PufL/M/PsbA/D family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QUQ7"/>
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        <property type="protein sequence ID" value="KJB10925"/>
        <property type="gene ID" value="B456_001G234300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWJF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009772">
        <property type="term" value="P:photosynthetic electron transport in photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.85.10:FF:000005">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.85.10">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055266">
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    </dbReference>
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        <property type="entry name" value="Photo_II_D1/D2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000484">
        <property type="entry name" value="Photo_RC_L/M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055265">
        <property type="entry name" value="Photo_RC_L/M_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149:SF57">
        <property type="entry name" value="PHOTOSYSTEM II D2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33149">
        <property type="entry name" value="PHOTOSYSTEM II PROTEIN D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00124">
        <property type="entry name" value="Photo_RC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81483">
        <property type="entry name" value="Bacterial photosystem II reaction centre, L and M subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00244">
        <property type="entry name" value="REACTION_CENTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="15" id="KW-0157">Chromophore</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="17" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="20" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="9 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB10925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="24">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27472" checksum="1F6A3F09672D61B5" modified="2015-04-29" version="1">MTIALGGWFTGTTFVTSWYTHGLANSYLEDCNFLTAAVFTPANSLVHFLLLLWGLEAQGDFTRWCQLGGLWTFVTLHDAFGLIGFMLRQFELARSIQLRPYNAITFSGPIAVVVSIFLIYPLGFHNWILNPFHMMGVVGVLGAALLYAIHGATVENTLFEDGDGVNIFRAFNPTQAEETYSMVTANHFWSQIFGEIRAAEDPEFETFYTKNILLNEGIRAWMAAQDQPHENLIFLEEVLPCGNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QV68</accession>
    <name>A0A0D2QV68_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G101700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QV68"/>
    <dbReference type="STRING" id="29730.A0A0D2QV68"/>
    <dbReference type="Gramene" id="KJB23499">
        <property type="protein sequence ID" value="KJB23499"/>
        <property type="gene ID" value="B456_004G101700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0087">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QIWDTTS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8952" checksum="23275E20ABF94245" modified="2015-04-29" version="1">MGAYKADYDYDYLFKVVLIGDSGVEKTNLFSRFTKNEFSLESTSTIGVEFATSSIRVDDKVIKAQIWDTTGQERFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QW64</accession>
    <name>A0A0D2QW64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G199900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant LTP family. PEARLI1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QW64"/>
    <dbReference type="STRING" id="29730.A0A0D2QW64"/>
    <dbReference type="Gramene" id="KJB21391">
        <property type="protein sequence ID" value="KJB21391"/>
        <property type="gene ID" value="B456_004G199900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792088"/>
    <dbReference type="eggNOG" id="ENOG502RZES">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTTHAWS"/>
    <dbReference type="OrthoDB" id="696558at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd01958">
        <property type="entry name" value="HPS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000003">
        <property type="entry name" value="pEARLI1-like lipid transfer protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027923">
        <property type="entry name" value="Hydrophob_seed_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051636">
        <property type="entry name" value="Plant_LTP/defense-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31731">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14547">
        <property type="entry name" value="Hydrophob_seed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266354" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB21391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="132" mass="13666" checksum="E1BF274397B039F4" modified="2015-04-29" version="1">MASKRSASLALFFALNILFFSLVSACDSCPSPKPRPKPTPFPSPSAKGKCPRDALKLGVCANVLGLVNVTIGSPPVQPCCSLLQGLADLEAAVCLCTAIKANVLGINLNVPVSLSLLLNVCSRKVPSGFQCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QY08</accession>
    <name>A0A0D2QY08_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G230800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QY08"/>
    <dbReference type="STRING" id="29730.A0A0D2QY08"/>
    <dbReference type="Gramene" id="KJB44028">
        <property type="protein sequence ID" value="KJB44028"/>
        <property type="gene ID" value="B456_007G230800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804112"/>
    <dbReference type="eggNOG" id="KOG2467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000050">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000005">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF61">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="56"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB44028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="517" mass="57226" checksum="AD3B729D6BDF02ED" modified="2015-04-29" version="1">MAMAMALRRLSSSIDKPLRPFFNAPSLYYMSSLPNEAVYEKEKPGVTWPKQLNAPLETVDPEIADIIELEKARQWKGLELIPSENFTSVSVMQAVGSIMTNKYSEGYPGARYYGGNEYIDMAETLCQKRALEAFRLDPEKWGVNVQPLSGSPSNFQVYTALLKPHDRIMALDLPHGGHLSHGYQTDTKKISAVSIFFETMPYRLNENTGYIDYDQLEKSATLFRPKLIVAGASAYARLYDYARIRKVCDKQKAIMLADMAHISGLVAAGVIPSPFEYADVVTTTTHKSLRGPRGAMIFFRKGVKGINKQGKEVLYDYEDKINQAVFPGLQGGPHNHTITGLAVALKQATTPEYKAYQEQVLSNCSKFAQTLAAKGYELVSGGTENHLVLVNLKNKGIDGSRVEKVLEAVHIAANKNTVPGDVSAMVPGGIRMGTPALTSRGFVEEDFVKVAEYFDAAVNLAVKIKAETTGTKLKDFVATLQSAHFQSEVAKLRQDVEEYAKQFPTIGFDKETMKYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZZ0</accession>
    <name>A0A0D2QZZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G182700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZZ0"/>
    <dbReference type="SMR" id="A0A0D2QZZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2QZZ0"/>
    <dbReference type="Gramene" id="KJB25273">
        <property type="protein sequence ID" value="KJB25273"/>
        <property type="gene ID" value="B456_004G182700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB25274">
        <property type="protein sequence ID" value="KJB25274"/>
        <property type="gene ID" value="B456_004G182700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791904"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPTCALE"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000235">
        <property type="entry name" value="Probable calcium-binding protein CML15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000123">
        <property type="entry name" value="probable calcium-binding protein CML18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051111">
        <property type="entry name" value="Ca-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46311:SF5">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB25274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="166" mass="18395" checksum="B0722883EE306700" modified="2015-04-29" version="1">MKMGDKQPTKLDEEQMAELREIFSSFDRNNDGSLTQLELGSLLRSLGLKPSLDQVEALIQKADSNNNGLIEFSEFVAMLAPELQPEKSPYSEEQLKQLFKMFDRDGNGFITAAELAQTMAKLGHALTVEELTGMIKEADADGDGRISFDEFSQAITSAAFHNNSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1X2</accession>
    <name>A0A0D2R1X2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G216500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1X2"/>
    <dbReference type="STRING" id="29730.A0A0D2R1X2"/>
    <dbReference type="Gramene" id="KJB25929">
        <property type="protein sequence ID" value="KJB25929"/>
        <property type="gene ID" value="B456_004G216500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792262"/>
    <dbReference type="eggNOG" id="KOG4341">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VSSHCRF"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:001044">
        <property type="entry name" value="F-box protein isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134:SF73">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16134">
        <property type="entry name" value="F-BOX/TPR REPEAT PROTEIN POF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB25929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="538" mass="59387" checksum="E30983B819E5527A" modified="2015-04-29" version="1">MDTLHHHHHRPTPPPSSSSTSMAKRPCSSSSSQNPRLPPHFSQMDHLLHSFLSFPDSSPPISLDLSFDRLLDSSPSDADQSILIDRAHRLGCLLLRAANRSARKRASIHNSVAWVLPPDLTIKVFSMLDSQSLCYAAATCSMFNKCAMDPLCYANIDLTTIVPKVNNAVVSTMIQRAGKSLQSLKLGIVPGPTGSPGSCQPLVYTIRNSGDVSSFSWNEKRTRQGKESSILTRSCLYPLSGDNGATGILLRRLHLYNIERMDNASLCVALAACPSLLDLEIVGLHVELRQTLMSVSSHCRFIERLFFESSKTGRDDSLKSPTCFELVNNCPNLSSLSLRGFKLHDNKVRILVKGFRKLEYADFSTSYSITGTFLRNLGNGGGGSLLEVLILRDCMHLKEMEVARFLTAVIAGDFKFLKHLDISNREGLASEGDWYQRSYNSSLIPLQQVLEVRPDICLLAEFPSEGCFLDIDHMIDSDINSELSLPFQQSGQTSDGALVTSSLESSYNSDQGSGNEEYQDSGFVIYEESSDEVDFLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2H3</accession>
    <name>A0A0D2R2H3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G227600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2H3"/>
    <dbReference type="SMR" id="A0A0D2R2H3"/>
    <dbReference type="STRING" id="29730.A0A0D2R2H3"/>
    <dbReference type="Gramene" id="KJB26159">
        <property type="protein sequence ID" value="KJB26159"/>
        <property type="gene ID" value="B456_004G227600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792372"/>
    <dbReference type="eggNOG" id="KOG2988">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIANNCP"/>
    <dbReference type="OrthoDB" id="931915at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_eL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_eL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB26159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="112" mass="12376" checksum="5479CA6483FD6CE5" modified="2015-04-29" version="1">MVAAKKTKKTHESINNRLALVMKSGKYTLGYKTVLKSLRSSKGKLIIIANNCPPLRKSEIEYYAMLCKVGVHHYNGNNVDLGTACGKYFRVCCLSIIDPGDSDIIKSMPGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R974</accession>
    <name>A0A0D2R974_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ZF-HD dimerization-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G044700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R974"/>
    <dbReference type="STRING" id="29730.A0A0D2R974"/>
    <dbReference type="Gramene" id="KJB47838">
        <property type="protein sequence ID" value="KJB47838"/>
        <property type="gene ID" value="B456_008G044700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R1WS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KRVFVVW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006455">
        <property type="entry name" value="Homeodomain_ZF_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006456">
        <property type="entry name" value="ZF_HD_homeobox_Cys/His_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01565">
        <property type="entry name" value="homeo_ZF_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01566">
        <property type="entry name" value="ZF_HD_prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948:SF169">
        <property type="entry name" value="MINI ZINC FINGER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04770">
        <property type="entry name" value="ZF-HD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51523">
        <property type="entry name" value="ZF_HD_DIMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZF-HD dimerization-type" evidence="12">
        <location>
            <begin position="70"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="10">
        <location>
            <begin position="168"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB47838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26376" checksum="010FDEB6A15B6DC5" modified="2015-04-29" version="1">MQFFPFKEQFHLPNHPTNTALLIINSLSLMEGETRNVVIKVEAESDVEPISVQRCCSLVSDQSNERICRYKECRRNHAASIGRYAIDGCGEFICCKDDVFMCAACGCHRSFHRKDYLPPPPQPKLMSSCLAPLPLASHNGLTGETSLFVKDRNNTVAGPGAEEQNTNKEAKRTRLTVEQKNKMMRFADKLGWRSQGHDDAEIRQFCEQVGITKRVFVVWLNNNRRRSRKGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHA1</accession>
    <name>A0A0D2RHA1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Pectate lyase superfamily protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G181400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHA1"/>
    <dbReference type="STRING" id="29730.A0A0D2RHA1"/>
    <dbReference type="Gramene" id="KJB31214">
        <property type="protein sequence ID" value="KJB31214"/>
        <property type="gene ID" value="B456_005G181400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794646"/>
    <dbReference type="eggNOG" id="ENOG502QWCM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMQNTMN"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000019">
        <property type="entry name" value="polygalacturonase At1g48100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262847" description="Pectate lyase superfamily protein domain-containing protein" evidence="11">
        <location>
            <begin position="24"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="56573" checksum="95DBD8EBD3D6BFEB" modified="2015-04-29" version="1">MGGVNFRSLTFMILIAFFVWCSSIETCIARRGKHWRQSRYAAALSKKKGGSHGHRNYHNGGSKPKPPPPQSHKATPSPKPKEEVPPSTPSPHGGYSYDQQSTVFNVLDFGAKGDGKSDDTKAFQDTWAAACKVEASTVVVPAEFVFLVGPISFSGPYCQANIVFQLDGTIIAPTDARPWGKGLLQWLEFTKLKGIAIQGKGILDGRGSGWWQDAPYEDPYDDERKLIIPLNSTVQERPPMPVRNELSGKMPSIKPTALRFYGSFNVTVTGITIQNSPQCHLKFDNCMGVVVHDITVSSPGDSPNTDGIHLQNSNDVLIHSSNLACGDDCVSIQTGCSNVYIHNVNCGPGHGISIGSLGRDNTKACVSNITVRDIVMHNTMNGVRIKTWQGGSGSVQGVLFSNIQVSEVQLPIVIDQFYCDKRKCSNETAAVALSGITYEKIRGTYTVKPVHFACSDSLPCIGVTLSAIELKPVQERYHLYDPFCWQTFGELTTPTVPPISCLQIGKPTNNRVQSDHDVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKY0</accession>
    <name>A0A0D2RKY0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G134500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKY0"/>
    <dbReference type="STRING" id="29730.A0A0D2RKY0"/>
    <dbReference type="Gramene" id="KJB30251">
        <property type="protein sequence ID" value="KJB30251"/>
        <property type="gene ID" value="B456_005G134500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794110"/>
    <dbReference type="eggNOG" id="ENOG502RZ5P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLVRICK"/>
    <dbReference type="OrthoDB" id="1901634at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB30251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="129" mass="15173" checksum="E2A798361593A9E6" modified="2015-04-29" version="1">MALQWMILTYVVAAEAALALLLTFPSPKLLKNRFVSLISLILQPTLFIVPFAGFQLLDIYWKNEHRLMCTSDICTAAERDRYEKSVFKAQRNVILCTTACLLYWCIYRICKYHKEIQSLEEVEKRYKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQA7</accession>
    <name>A0A0D2RQA7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small acidic protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G3363001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQA7"/>
    <dbReference type="Gramene" id="KJB53370">
        <property type="protein sequence ID" value="KJB53370"/>
        <property type="gene ID" value="B456_009G3363001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53371">
        <property type="protein sequence ID" value="KJB53371"/>
        <property type="gene ID" value="B456_009G3363001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53372">
        <property type="protein sequence ID" value="KJB53372"/>
        <property type="gene ID" value="B456_009G3363001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53373">
        <property type="protein sequence ID" value="KJB53373"/>
        <property type="gene ID" value="B456_009G3363001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53374">
        <property type="protein sequence ID" value="KJB53374"/>
        <property type="gene ID" value="B456_009G3363001"/>
    </dbReference>
    <dbReference type="OMA" id="MEFVRDT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB53373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6699" checksum="E67A4356EC8D4BF9" modified="2015-04-29" version="1">MRPTPMEFVRDTDDKGSAMEVDGVDTPEIFGEGAIASDNKLAYADFFNNFEDDFDDSNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUR6</accession>
    <name>A0A0D2RUR6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocon-associated protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G000600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUR6"/>
    <dbReference type="STRING" id="29730.A0A0D2RUR6"/>
    <dbReference type="Gramene" id="KJB33206">
        <property type="protein sequence ID" value="KJB33206"/>
        <property type="gene ID" value="B456_006G000600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3317">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEWRLMA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861:SF3">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12861">
        <property type="entry name" value="TRANSLOCON-ASSOCIATED PROTEIN, BETA SUBUNIT PRECURSOR TRAP-BETA SIGNAL SEQUENCE RECEPTOR BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05753">
        <property type="entry name" value="TRAP_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15069" checksum="ED3AA3421C8FD3AB" modified="2015-04-29" version="1" fragment="single">NFRAAYDLSLIDNSWPQDAFDIVNGNTSHSWQKLDAGGHLSHSFELEAKRKGMFHGAPAVIYFRIPTKSVQQEAYSTPIFPLDILEERPPEKKFEWAKRLMAKYGSQISVISIVVLFIYLIITPSKASKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUT1</accession>
    <name>A0A0D2RUT1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_011G1614001</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="9"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUT1"/>
    <dbReference type="STRING" id="29730.A0A0D2RUT1"/>
    <dbReference type="Gramene" id="KJB74492">
        <property type="protein sequence ID" value="KJB74492"/>
        <property type="gene ID" value="B456_011G1614001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2448">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFKYWDE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="12">
        <location>
            <begin position="189"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB74492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="376" mass="40071" checksum="2F6DAE127A16C3A6" modified="2015-04-29" version="1" fragment="single">PGHFQGNTYDIVSAFQCYGEYVSGSISDEQRMNVVRNSCPGAGACGGMYTANTMASAIEAMGMSLPYSSSIPAEDPLKLDECRLAGKYLLKLKLVEITPGNIHARSVGLELTLDDFQKVSDEVPFLADLKPSGKYVMEDMHKIGGTPAVIRYLLEFGYLDGDCMTVTGRTMAENAKSYPCLPEGQTGVNPIKKTGHIQILRGNLAPEGSVAKIIGKEGLHFSGPALVFEGEEAMLAAISENPMSFKGKVVVIRGEGPKGAPGMPEMLTPTSAIMGAGLGKDVALLTDGRFSGGSHGFVVGHVCPEAQEGGPIGLIQNGDAISIDVQKRAINVQLTDDELNERRKTWTPPPYKANRGTLHKYIKNVQSASMGCVTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVU8</accession>
    <name>A0A0D2RVU8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G087200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVU8"/>
    <dbReference type="Gramene" id="KJB23245">
        <property type="protein sequence ID" value="KJB23245"/>
        <property type="gene ID" value="B456_004G087200"/>
    </dbReference>
    <dbReference type="OMA" id="AISKIIC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB23245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="99" mass="10813" checksum="4F4EE520E51745F8" modified="2015-04-29" version="1">MAELGIQNRPLLDPGPVESIVEINKELLDSSNHSVVTFKGKNRLNIAKSIEAGISVGRDKGIPISKVRVSRTKGDNVRNNGAISKIICERRGILKILRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RX06</accession>
    <name>A0A0D2RX06_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G157100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36394">
        <property type="protein sequence ID" value="KJB36394"/>
        <property type="gene ID" value="B456_006G157100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACGYFVQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000179">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000059">
        <property type="entry name" value="ABC transporter G family member 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013581">
        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48040:SF42">
        <property type="entry name" value="ABC TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48040">
        <property type="entry name" value="PLEIOTROPIC DRUG RESISTANCE PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="558"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1184"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1214"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1262"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1327"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1358"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1408"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="167"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="838"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB36394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1439" mass="162756" checksum="47282D7A0F54A307" modified="2015-04-29" version="1">MASALAGDDLLARSMSSGRSYRSWTSASFKEVWQAPPEAFGRSGRQDEEEEELRWAAIERLPTYDRLRKGMLTQILDNGKVVHHEVDVAKLGMQAKKQLMASMLKVVEEDNEKFLRRLRDRTDRVGIEIPTIEVRFQHLEVEGDVYVGSRALPTLLNVTLNTIESILGLLRLAPSKKRKNQILKDVSGIVKPSRMTLLLGPPGAGKTTLLMALAGKLDRDLRSSGKVTYCGHDLNEFVPQRTCAYISQHDLHYGEMTVRETLDFSGRCLGVGTRYEMLSELSRREKEVGIKPDPEIDAFMKATAVAGQETSLVTDYILKILGLDICADIMVGDDMRRGISGGQKKRVTTGEMLVGPAKALFMDEISTGLDSSTTFQICKFMRQMVHTMDVTMIISLLQPAPETFDLFDDVIVLSEGQIVYQGPRESVLDFFEFMGFKCPERKGIADFLQEVTSKKDQQQYWFQKSLPYGYVSVSDFVNGFSCFCIGQQLSMDLKVPYDKTSTHPAALACFAREWLLMKRNSFVYIFKTVQITIMSLIALTVFLRTEMPVGSLENGQKFFGALFFSLINVMFNGTAELAMTIFRLPVFYKQRDLLFYPAWGFGLPIWVLRIPLSLMESGIWIALTYYTIGFAPAASRFFRQFLAFFGVHQMALSLFRFIAAIGRTEVVANTLGTFTLLLVFVLGGFIIAKKLLLADDIEPWMIWGYYVSPMMYGQNAIVMNEFLDERWSANNTDPRIDAPTVGKVLLKTRGFFTEEYWFWICVGALFAFSLVFNILFIGALTFLNPLGGSKAVVVNEDEKKTKNPYSGGRIPEGIHMKARNSSNNPRKGMVLPFQPLSLAFNHVNYYVDMPAEMKTQGIEVDRLQLLRDVSGAFRPGILTALVGVSGAGKTTLMDVLAGRKTRGYIEGHISISGYTKNQATFARVSGYCEQNDIHSPHVTVYESLLYSAWLRLASDTDTSTRKMFVEEVMELVELKPLRNALVGLPGIEGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLMKRGGQVIYSGPLGRHSHKLIEYFEAVQGVPKIRDGYNPATWMLEVSAPSVEAQLDVDFADIYANSSLYRMNQELIKELSAPAPGTKDLFFPTQYSQPFLTQCKACFWKQHWSYWRNPQYNAIRFFMTTVIGILFGIIFWNKGQRISRQQDLMNLLGAMYSAVLFLGATNAAAVQSVVAIERTVFYRERAAGMYSELPYAFAQVAIEIIYTAIQTLIYTLLIYSMIGFEWTPVKFLWFYYYILTCFIYFTLYGMMVVALTPGHQIAAIVMSFFLSFWNLFSGFLIPRTQIPIWWRWYYWASPVAWTLYGLVTSQVGDKDGPLEVPGRQNMTVKGFLKEDLGFEYSFLPAVAVAHVGWCLLFFFVFAYGIRFLNYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RXL0</accession>
    <name>A0A0D2RXL0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G101900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2RXL0"/>
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        <property type="gene ID" value="B456_009G101900"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB55943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="345" mass="38370" checksum="5519C0A6B4248F85" modified="2015-04-29" version="1">MAGALPTTKGVKDHKIWKGIFAVSGIMVTLVIYGVLQEKIMRVPYGLNKEYFKYSLFLVFCNRITTSTVSAVFLLASKKALVPVAPIYKYCLISASNILTTTCQYEALKYVSFPIQTLAKCAKMIPVMIWGTFIMQKTYKGFDYLVAFLVTLGCSIFILFPAGTDVSPYSKGRESTVWGISLMVGYLGFDGFTSTFQDKLFKGYDMEIHNQIFYTTSCSCILSLTGLLLQGHLLSAIDFVYRHSDCFLDIVLLSTVTTVSQFFISYTIRTFGALTFAAVMTTRQLVSIMLSCVWFGHPLSWEQWIGAVIVFGSLYSKNFLKKASTNPPPLQPMQDGAPSPVKGIP</sequence>
</entry>
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            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S047"/>
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        <property type="gene ID" value="B456_006G210100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800242"/>
    <dbReference type="eggNOG" id="ENOG502QPMH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31960:SF22">
        <property type="entry name" value="F-BOX PROTEIN PP2-A12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31960">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJB37554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="33084" checksum="8D1F4AF4C9CB1C3F" modified="2015-04-29" version="1">MGAYFSVLFINQGGLSSVSSSSPSLGDLPESCVALIIGYLDPPEICKLGKLNRAFRGASWADFVWESKLPSNYQVLVDKILTFAPENLGKREIYSLLCTTNTLDGGTKKVWLDKSSGGLCMSISSKGLHITGIDDRRYWNHIPTDESRFHSIAYLQQTWWFEVDGEVEFPFPAGSYSVFFRLQLGRSSKRFGRRICNSEHIHGWDKKPVRFQLWTSDGQHARSQCTLNEPGKWFHYHIGDFNVKNSNSSTKIKLSMTQIDCTHTKGGLCLDSVVIYPSKYREKLKQKGFLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2C0</accession>
    <name>A0A0D2S2C0_GOSRA</name>
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            <fullName evidence="7">CHCH domain-containing protein</fullName>
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    <gene>
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    </gene>
    <organism evidence="5 6">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G189600"/>
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    <dbReference type="KEGG" id="gra:105793671"/>
    <dbReference type="eggNOG" id="KOG3057">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
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    </dbReference>
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        <property type="entry name" value="COX6B-like"/>
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        <property type="entry name" value="CX6/COA6-like_sf"/>
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    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
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        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB25395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14475" checksum="088ECD57D1C0FA2A" modified="2015-04-29" version="1">MSSTGAAVDPRDKMRARDVNRVARGEQAPRPVHEYGTVSAPPSPQSTSPPPARKIANKDMARKVAEGEEDVAPKASHCYDSYVEYHKCIKEKGKDAPQCDKLARHFRSLCPDEWIERWDEARAVGTFPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3X3</accession>
    <name>A0A0D2S3X3_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G186800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMGB family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S3X3"/>
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    </dbReference>
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    <dbReference type="OMA" id="KMPQSAF"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000044">
        <property type="entry name" value="High mobility group B1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR031061">
        <property type="entry name" value="HMGB_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261:SF22">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46261">
        <property type="entry name" value="HIGH MOBILITY GROUP B PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="39"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="148" mass="16470" checksum="429C156A1815D2E8" modified="2015-04-29" version="1">MKGGKSKSDTKSSRLAVNKKSSAKAGKKSGKAAKDPNKPKRPASAFFVFMEEFREQYKKEHPKNKSVAAVGKAGGDKWKSLSDAEKAPYIAKAEKRKVEYEKNMKAYTKRQAEAPKEEESESEKSVSEVNDEEDEDDEEGSGEEEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7Q7</accession>
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        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G289700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7Q7"/>
    <dbReference type="STRING" id="29730.A0A0D2S7Q7"/>
    <dbReference type="Gramene" id="KJB27300">
        <property type="protein sequence ID" value="KJB27300"/>
        <property type="gene ID" value="B456_004G289700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128:SF60">
        <property type="entry name" value="ALPHA-LATROTOXIN-LHE1A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128">
        <property type="entry name" value="HOMEOBOX PROTEIN WARIAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB27300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="454" mass="51471" checksum="198215091F8A2A08" modified="2015-04-29" version="1">MDPSLREVAGTGDTDALYALIRKDPYMLEHIDQIPFIDTPLHIAANEGQIKFAMEMINLKPSFGRKLNQDGFSPMHLALQMGHTKLVLRLLKTDKDLVRVKGREGMTPFHCAAAVGNSNLLFHFLETCPECVEDVTVRNETALHLALKNDHTDAFNLLHGWLRKNRRGGGNGLERKVVNWRDDDDNTVLHIAATKQQHQAVQLLLDSFYGLDANAKNSEGLTAREIIERVERQGLNMSGAEDDDTTTAKIERIKKRTSRSERALVKLIRARNGLSENMLNATLVVAALVITAIYQSSLSPPRGLWQGDNTSIPTTTSNLTTTTKFKLFNDNYSEYRFKFLLGEETRKTGTAVMNPNLFLGFWFFNFIAFGLPVLLTVLLLSNVPSILLIPLYYLSVSYFNCMTIVSPSTFWANLNFVVMWTAILLPLLLVVRSVWLSKQPKYREIRQLRRLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBL5</accession>
    <name>A0A0D2SBL5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flowering-promoting factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G059900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FPF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBL5"/>
    <dbReference type="STRING" id="29730.A0A0D2SBL5"/>
    <dbReference type="Gramene" id="KJB28645">
        <property type="protein sequence ID" value="KJB28645"/>
        <property type="gene ID" value="B456_005G059900"/>
    </dbReference>
    <dbReference type="OMA" id="TKYYQST"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039274">
        <property type="entry name" value="FPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33433">
        <property type="entry name" value="FLOWERING-PROMOTING FACTOR 1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB28645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14800" checksum="919B2E98909F92E6" modified="2015-04-29" version="1">MTKYYQSTNPDTKTCIKNNTPTKRSIKNNDVVRLVENSGSDQRPNPEGKLLVHTPSNEVTTSYEILETKLLSLGWERYYGSDPDLFQFHKRSSIHLISLPKEFTKFKSVYMYDIVVKNPNMFMVMDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDU8</accession>
    <name>A0A0D2SDU8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DisA/LigA helix-hairpin-helix motif domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G352800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDU8"/>
    <dbReference type="STRING" id="29730.A0A0D2SDU8"/>
    <dbReference type="Gramene" id="KJB61353">
        <property type="protein sequence ID" value="KJB61353"/>
        <property type="gene ID" value="B456_009G352800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SYFQYEM"/>
    <dbReference type="OrthoDB" id="1857825at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039172">
        <property type="entry name" value="PTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37394">
        <property type="entry name" value="PROTEIN PARTING DANCERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37394:SF1">
        <property type="entry name" value="PROTEIN PARTING DANCERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB61353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28001" checksum="057C32DABDE58323" modified="2015-04-29" version="1">MANFKSGYADPVLENPCSKVTKSSVSAGVCMMNTTWRDQQHPSFISFISSFLAANSFRLNFVPISPDFIFNCGGLSVAFIFVTKWDCGNVGTIFSRAKKLKAQFAHLYVTLNLPTRDQNDSFLCSYFKYEMQLGRPTFVPVQDIEMGFEKIVKIAHSCGVSKQQEVKSKLKAERNQSVQELENFIRVVTSIPGIDNHDANALNQAIGSIEGIAKASKEYILETTDLSADKAETIVRFFRDSKFYLCPKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHP1</accession>
    <name>A0A0D2SHP1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAWADEE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G219600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHP1"/>
    <dbReference type="STRING" id="29730.A0A0D2SHP1"/>
    <dbReference type="Gramene" id="KJB82727">
        <property type="protein sequence ID" value="KJB82727"/>
        <property type="gene ID" value="B456_013G219600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782711"/>
    <dbReference type="eggNOG" id="ENOG502QQU4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1885884at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032001">
        <property type="entry name" value="SAWADEE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039276">
        <property type="entry name" value="SHH1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33827:SF3">
        <property type="entry name" value="OS09G0346900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33827">
        <property type="entry name" value="PROTEIN SAWADEE HOMEODOMAIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16719">
        <property type="entry name" value="SAWADEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAWADEE" evidence="1">
        <location>
            <begin position="139"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="270" mass="31193" checksum="46B336FEB54400D4" modified="2015-04-29" version="1">MDRLRPRQRPVFSGFTKAEIEKMEKLFMESRELLQSKEFFQKLARNFSSSSGRAGKPIVKWNEFRNSPIIPSPTFVSQVQNWFTTRQQESKVKVPSVTNTYKDESGLPQTCLLNDGDQSCQILKGLVSKVGEKVSDLSKLEFEAKSSTDGAWYDVDMFLSHRVTSSGETEVRVRFVGFGAEEDEWVNIKKAVRGRSIPFEHSECCKVMVGGLVLCLQERRDQSIYYDAHVLEIERKTHDIRGCRCLFFIRYDHDNSEETVRLRRLCRILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SIC7</accession>
    <name>A0A0D2SIC7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G221900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SIC7"/>
    <dbReference type="STRING" id="29730.A0A0D2SIC7"/>
    <dbReference type="Gramene" id="KJB82952">
        <property type="protein sequence ID" value="KJB82952"/>
        <property type="gene ID" value="B456_013G221900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782600"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEEHMQY"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="10">
        <location>
            <begin position="287"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="783" mass="88718" checksum="10882F95D18A8B0F" modified="2015-04-29" version="1">MATNPARAPSKLPKSGAISKGYNFASTWEQNAPLTEQQQRAIQMLSHAVAERPFPANLAQERTSGQDKGLSVSTKDDNFRDSEAIDEILVNSNQFYKWFTDLESALRSESEEKYQHYVDTLVDRIQTCDDILRQVDETLDLFNELQLQHQAVETKTKTLHDACNRLVMEKQRLIEFAEALRSKLEYFDELENITSNFYSPNMNVGNANFLPLLKRLDECILYVENNPQYAESSVYLLKFRQLQSRALGMIRSHVVSVLKSASSQVQAAIWSSGGNKESLSEGVEASIIYVRFKAAASELKPILEEIESKASRKEYVHLLAACHKLYCEQRLSLIKGTVHQRISEFAKKEGLPSLTRSGCAYLMQVCQLEHQLFHHFFPSSSEDVSSLAPLIDPLSTYLYDTLRPKLIHEANVDFLCEMVDILKVEVLGEQLSRKSESLAGLRPSLERILADIHERLTFRARTYIRDEIANYIPINEDLNYPAKLEHSADVVSETATNANPDVFKTWYPPLEKTISFLSKLYRSLEPAVFTGLAQEAVEVCSVSIQKASKLIAKRSTPMDGQLFLIKHLLILREQIAPFDIEFSVTHKELDFSHLLENLRRILRGQTSLFDWSGSTSLARTLSPRVLESQVDAKKELEKSLKATCEEFIMAVTKQVVDPMLSFVTKVTAVKVALSSGTQNQKRDSVMAKPLKEQAFATPEAVAELVQKVHLAIQRELPVVIAKMKLYLQNSSTRTILFKPIKTNIVEAHIQIQSLLKAEYSPEENRTINMVPIEELESQLDNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLX1</accession>
    <name>A0A0D2SLX1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G226800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLX1"/>
    <dbReference type="STRING" id="29730.A0A0D2SLX1"/>
    <dbReference type="Gramene" id="KJB32145">
        <property type="protein sequence ID" value="KJB32145"/>
        <property type="gene ID" value="B456_005G226800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795128"/>
    <dbReference type="eggNOG" id="KOG2449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEYATYV"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="51"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="538" mass="57672" checksum="E2B011DC9A3F30E1" modified="2015-04-29" version="1">MMRFSLQKVKNLPALRPQVLASASPRFSTATESSFNHRNPSRVPNLIGGAFVDSKSTSTIDVINPATQEVVSQIPLTTNEEFKAAVAAAKQAFPSWRNTPITTRQRIMFKLQELIRRDMDKLAKNITTEQGKTLKDAHGDVFRGLEVVEHSCGMATLQMGEYVPNVASGIDTYSVREPLGVCAGICPFNFPAMIPLWMFPVAVTCGNTFVLKPSEKDPGASIMLAELAIEAGLPPGVLNIVHGTNDIVNAICDDDDIRAISFVGSNTAGMHIYGRASAKGKRVQSNMGAKNHGIVMPDANKDATLNALLAAGFGAAGQRCMALSTIVFVGDSESWLNDLVERAKGLKVNAGIEPNADLGPVISKQAKERICRLVQSGVERGAKLLLDGRNVVVPGYEQGNFIGPTILTGVTADMKCYKEEIFGPVLVCMKADSLEDALNIVNRNKYGNGASIFTTSGAVARKFQTEVEAGQVGINVPIPVPLPFFSFTGNKASFAGDLNFYGKAGVNFFTQIKTVTQQWKDLPSGSGVSLAMPTSQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SPX7</accession>
    <name>A0A0D2SPX7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G198000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SPX7"/>
    <dbReference type="STRING" id="29730.A0A0D2SPX7"/>
    <dbReference type="Gramene" id="KJB33315">
        <property type="protein sequence ID" value="KJB33315"/>
        <property type="gene ID" value="B456_006G198000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1735">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YAIYDME"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000025">
        <property type="entry name" value="Actin-depolymerizing factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="136" mass="15615" checksum="9E40E8A2A284C830" modified="2015-04-29" version="1" fragment="single">ANAASGMAVDDECKLKFLELKAKRNYRFIVFKIQEQQVVVEKVGSPQETYEDFTAALPADECRYAVFDFDFTTDENCQKSKIFFIAWSPDTSRVRSKMVYASSKDRFKRELDGIQVELQATDPSEMSFDIIKARAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRM0</accession>
    <name>A0A0D2SRM0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G266300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRM0"/>
    <dbReference type="Gramene" id="KJB44681">
        <property type="protein sequence ID" value="KJB44681"/>
        <property type="gene ID" value="B456_007G266300"/>
    </dbReference>
    <dbReference type="OMA" id="LHSTDYK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB44681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="9194" checksum="E71E91E38DF2B6E9" modified="2015-04-29" version="1">MVFFPSIVLLSSIENPDSRAGLYQVSDVIRRGQDSNLHSTDYKPDELTITLPRFFPFTFFHYSHLSSWLWLLGRDRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SY94</accession>
    <name>A0A0D2SY94_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIR1-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G151100</name>
        <name evidence="4" type="ORF">Gorai_001050</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SY94"/>
    <dbReference type="STRING" id="29730.A0A0D2SY94"/>
    <dbReference type="Gramene" id="KJB36295">
        <property type="protein sequence ID" value="KJB36295"/>
        <property type="gene ID" value="B456_006G151100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36296">
        <property type="protein sequence ID" value="KJB36296"/>
        <property type="gene ID" value="B456_006G151100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S48P">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYVMLAE"/>
    <dbReference type="OrthoDB" id="1930194at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055281">
        <property type="entry name" value="GIR1-2/SIED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056440">
        <property type="entry name" value="Zn-ribbon_GIR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33177:SF74">
        <property type="entry name" value="PROTEIN GL2-INTERACTING REPRESSOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33177">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24747">
        <property type="entry name" value="Zn-ribbon_GIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIR1-like zinc ribbon" evidence="2">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB36295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0587930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="116" mass="12527" checksum="C107B2F1D9BAA438" modified="2015-04-29" version="1">MSRRNAPKLELKLNLSPPRARVNPGVESPSRSATISPTSPPSSCVSSEMNQDVDAANVRYSSSPEATSMVLVGCPRCLMYVMLSEDDPKCPKCKSAVLLDFLHDTATTTTIKTRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1P5</accession>
    <name>A0A0D2T1P5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G166900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1P5"/>
    <dbReference type="STRING" id="29730.A0A0D2T1P5"/>
    <dbReference type="Gramene" id="KJB50369">
        <property type="protein sequence ID" value="KJB50369"/>
        <property type="gene ID" value="B456_008G166900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764362"/>
    <dbReference type="eggNOG" id="ENOG502QS6G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LYDGHSK"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31288">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31288:SF10">
        <property type="entry name" value="PROTEIN ESMERALDA 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB50369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="561" mass="63600" checksum="12A2725C5F40D7CA" modified="2015-04-29" version="1">MHAKNRISSSGHSTPSPPASPLRSPRYRHGRKPGRFSPFQPGRTVAHHVAWLLLSVLLRRQGIFLFAPLIYISGMLIYMGTVSFDVVPLVKHRPAPGSVYRSPQVYEKLKIEMNEDYSSADAILTIWKNSYKGGEWRPCVSKPSEGLPESNGYIYVEANGGLNQQRTSICNAVAVAGYLNATLLIPNFHFHSIWRDPSKFKDIYDEDYFISALENNVQVVDKIPEYIMERFDHNLTNVYNFKIKAWSSIQYYRDEVLPKLLEEKIIRISPFANRLSFDAPPAVQRLRCLANYEALRFSSTILSLGETLVARMKKLSANTGGKYVSVHLRFEEDMVAFSCCVFDGGEQEKEDMKNARERGWKGKFTKPGRVIRPGAIRINGKCPLTPLEVGLMLRGMGFGNNTYIFLASGKIYNAEKTMAPLLDMFPNLQTKQMLASEEELAPYKNFSSRMAAIDYTVCLHSEVFVTTQGGNFPHFLMGHRRYLFGGHSKTIRPDKRKLALLFDNPNIGWKSFKRQMLNMRSHSDSKGFELKKLVDSIYTFPCPDCMCRTNKSTNPGSSSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1Y2</accession>
    <name>A0A0D2T1Y2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G210600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="168"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="296"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="426"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB37560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="483" mass="53301" checksum="FC4FF22B74B9652D" modified="2015-04-29" version="1">MDDPTLSNQRNQSVPSTPSLNVPTTMSDSSFHLENLPYRTMHINRMINSSYNRSPSRTIYSDRFIPSRSGSNFALFDISNSPTSTEGKEDGSGTYNSLLRAALFGPDTPDKKDSLDAPACRNIFRYKTETKRSLHSLSPFGLDDSVPGISHSPVKAPRKVPRSPYKVLDAPALQDDFYLNLVDWSSNNVLAVGLGNCVYLWNACSSKVTKLCDLGIDDSVCSVSWAQRGTHLAVGTSDGEVEIWDASRCQRVRTMEGHRLRVGALAWSSSLLSSGSRDKSILQRDIRAPDDFASKLSGHKSEVCGLKWSYDNRELASGGNDNKLFVWNQHSTQPVLKYCEHNAAVKAIAWSPHLHGLLASGGGTADRCIRFWNTTTNTHLSCMDTGSQVCNLVWSKNVNELVSTHGYSQNQIIVWRYPTMSKLATLTGHTYRVLYLAISPDGQTIVTGAGDETLRFWNVFPSPKSQNTDSEIGASSFGRTTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T9U8</accession>
    <name>A0A0D2T9U8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G3013002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB53369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T9U8"/>
    <dbReference type="Gramene" id="KJB53369">
        <property type="protein sequence ID" value="KJB53369"/>
        <property type="gene ID" value="B456_009G3013002"/>
    </dbReference>
    <dbReference type="OMA" id="SHSPCDA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB53369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="70" mass="7848" checksum="1746AB82BCFCDB05" modified="2015-04-29" version="1">MSERVRQKCSHSEEKYQTNISLATLDSGCLNSATVCGVDWTTLPDDTSHSPCDARISRDLNFLQQAQQMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TAT5</accession>
    <name>A0A0D2TAT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G224100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
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                <person name="Dennis E.S."/>
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                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">8</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <name evidence="5" type="ORF">Gorai_018277</name>
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        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Sanders W.S."/>
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                <person name="Scheffler J.A."/>
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                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <source>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <tissue evidence="3">Leaf</tissue>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </comment>
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        <property type="protein sequence ID" value="KJB77703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQ41"/>
    <dbReference type="STRING" id="29730.A0A0D2TQ41"/>
    <dbReference type="Gramene" id="KJB77703">
        <property type="protein sequence ID" value="KJB77703"/>
        <property type="gene ID" value="B456_012G152000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010431">
        <property type="term" value="P:seed maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02243">
        <property type="entry name" value="cupin_11S_legumin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02242">
        <property type="entry name" value="cupin_11S_legumin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006044">
        <property type="entry name" value="11S_seedstore_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050253">
        <property type="entry name" value="Seed_Storage-Functional"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189">
        <property type="entry name" value="OS03G0336100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189:SF45">
        <property type="entry name" value="OS09G0552500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00439">
        <property type="entry name" value="11SGLOBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0708">Seed storage protein</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0758">Storage protein</keyword>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="30"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="223"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB77703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="388" mass="42381" checksum="8BAC530EF77DFC30" modified="2015-04-29" version="1">MYIYIVFVIYIVIPFICRSKEKVQVKKMDLDLSPKFPATFVETEDGGYYNWAAADSPVLREAKVAAGKLVLKPRGFALPHYADCSKVGYVLEGKCGVGLTTTASNTKEKMAFIGIKKGDIIPVPCASVSCWYNYGDSDVVIVFLADATNAYVAGEITYFLLTGPLGHLHAFSLESIAKTYQISPQKAQKLTSNQKGLLLIKLNQEQAETIPKPNEELLNIYTQNINGSLPDVEVNNGGNFTTLKPSKFPFLEQVGLNVSRLVLETNATRAPWYASDPQVVYVVKGSGEVQIVGLQGKLVLNTKVETGQLFVVPKLFMVAISADENGLELISIVTSTRAIMGEMGSKNSVFNTSPSILQVSLNVSSELNQQLIEMMETGTIIVTPVNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQV4</accession>
    <name>A0A0D2TQV4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G335400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQV4"/>
    <dbReference type="STRING" id="29730.A0A0D2TQV4"/>
    <dbReference type="Gramene" id="KJB45890">
        <property type="protein sequence ID" value="KJB45890"/>
        <property type="gene ID" value="B456_007G335400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761379"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARKHEQP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009805">
        <property type="term" value="P:coumarin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000023">
        <property type="entry name" value="Feruloyl CoA ortho-hydroxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF753">
        <property type="entry name" value="FERULOYL COA ORTHO-HYDROXYLASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="9">
        <location>
            <begin position="200"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB45890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="366" mass="41069" checksum="FEB018C8BDF5B01C" modified="2015-04-29" version="1">MGPSFDDGTSLYNFVVRDGNGVKGMVDSGLTTVPAAYMQPPRERIDKESARKHEQPPIDLSRLDGPEHDEVAVEIVRAAETLGFFQVINHGVPVDLLESLKDTANKFFGLPPEQKAVYRSEVSPTPLVKYGTSFVPEKEAALEWKDYISLQYVNDAEALQHWPIEIRDVALEYLRTSIKMVRKLLEVLMVNLGMKLVDPKIDALIDKKMVNMNFYPTCSNPDLTVGVGRHSDMGTITVLLQDGIGSLYVKIEEDMRFGKKGEWVEIPPTPGALVINVGDMLQVLSNKRYKSAEHRVRTTNTTSRVSIPIFTIPKLTEKIAPLPHLVEKDGIAHYREFMFADYMKNFFGNAHEGKKSLDFAKNVDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTD1</accession>
    <name>A0A0D2TTD1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein HEADING DATE REPRESSOR 1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G085500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTD1"/>
    <dbReference type="SMR" id="A0A0D2TTD1"/>
    <dbReference type="STRING" id="29730.A0A0D2TTD1"/>
    <dbReference type="Gramene" id="KJB46650">
        <property type="protein sequence ID" value="KJB46650"/>
        <property type="gene ID" value="B456_007G085500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802527"/>
    <dbReference type="eggNOG" id="ENOG502RXJT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRIDWKP"/>
    <dbReference type="OrthoDB" id="1907556at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009909">
        <property type="term" value="P:regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038864">
        <property type="entry name" value="HDR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37205">
        <property type="entry name" value="F23A5.30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37205:SF1">
        <property type="entry name" value="F23A5.30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB46650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24418" checksum="4B1B67B578821527" modified="2015-04-29" version="1">MEKEEKKKKMEVDSAPAAALEGFSPVSTTRIFWNSRKRSASGRNLDKVTEETANVTPTKQEEQTLDQDNTPDSATSSELSERRKALFEPLEPIKNINGRRPSAESLLPPPDFDAASYPKGWLIGKKRKLVNVDVVESMRRIAVQEMNRKDREIDGLNEQLEEDARCLEHLQLQLLQEKSKRSEVERENAMLQEQVSMLMNMLQEGEEGPDDHEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TX35</accession>
    <name>A0A0D2TX35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G291900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TX35"/>
    <dbReference type="STRING" id="29730.A0A0D2TX35"/>
    <dbReference type="Gramene" id="KJB60152">
        <property type="protein sequence ID" value="KJB60152"/>
        <property type="gene ID" value="B456_009G291900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60156">
        <property type="protein sequence ID" value="KJB60156"/>
        <property type="gene ID" value="B456_009G291900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770377"/>
    <dbReference type="eggNOG" id="ENOG502RXWT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF15">
        <property type="entry name" value="GCN5-RELATED N-ACETYLTRANSFERASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="122"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="294" mass="32483" checksum="D9CBA783DF95DD39" modified="2015-04-29" version="1">MVGTTISSTTSTQIMIIQRGGSGAAFPSKSMELRWIRSNSRRKNSNLSSREFGGLKSIPPPLVMPIYISTDPSHINIQELSELYTCCNHSCHRFPKVDPHTGIVQEVMDLDKLHIALSHSCVVVSVFCKPQHAKVTNTTKQNQSQEQQEQIKTGLVGDLMENVMPVNPSNGQLVGFGRAVSDLGLTASIYDVMVVPTLQGMGIGTIIVKRIVRMLTSRDIYDIAALCSRKERFFFKACGFRDDILGSTTMMYTRTVSSTRFEGERMVKQAGRKLLLVPSLQLPLASSKTTKPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXR5</accession>
    <name>A0A0D2TXR5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G086200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXR5"/>
    <dbReference type="STRING" id="29730.A0A0D2TXR5"/>
    <dbReference type="Gramene" id="KJB80208">
        <property type="protein sequence ID" value="KJB80208"/>
        <property type="gene ID" value="B456_013G086200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782275"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HERIILI"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF132">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MPSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB80208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="208" mass="23698" checksum="3F6D5B7F911DC03D" modified="2015-04-29" version="1">MASETEAPEISSLFERLLRHRDLYFFLPFILGVSNNSVSRENSENPDQETSQETTSQRERIILVNPFTQGMVVVEGDSNLEALLRGWVNKDGQPPASKASIEAMPSVKIGEIEDGECVVCLEEWKSGEVVKEMPCKHKFHDECIQKWLVIHGSCPVCRYKMPVDEEDMGKKRDEERSRREIWVSLSFDSTRRTGDSNQVPSTDNEMEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U384</accession>
    <name>A0A0D2U384_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G1844001</name>
        <name evidence="7" type="ORF">Gorai_003275</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0603118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U384"/>
    <dbReference type="STRING" id="29730.A0A0D2U384"/>
    <dbReference type="Gramene" id="KJB82158">
        <property type="protein sequence ID" value="KJB82158"/>
        <property type="gene ID" value="B456_013G1844001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1269">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHRNLEE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025774">
        <property type="entry name" value="PiNMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF81">
        <property type="entry name" value="MAGNESIUM PROTOPORPHYRIN IX METHYLTRANSFERASE, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51581">
        <property type="entry name" value="SAM_GTMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="4">
        <location>
            <begin position="72"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="4">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB82158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0603118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="228" mass="25143" checksum="1A5525507DAAA125" modified="2015-04-29" version="1" fragment="single">DPANRPKRIVDVGCGIGGSSRYLARKYGAKCQGITLSPVQAGRANALANAQGLADQVCFEVADALNQPFPDDQFDLVWSMESGEHMPDKPKFVKELVRVAAPGGTIIVVTWCHRDLGPSEESLQPWEQKLLNRICDAYYLPEWCSTSDYVKLFQSLSLQDIKAGDWTENVAPFWPAVIRSALTWKGFTSLLRSGLKTIKGALVMPLMIEGFQKGVIKFAIIACRKPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3L6</accession>
    <name>A0A0D2U3L6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G422200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3L6"/>
    <dbReference type="Gramene" id="KJB62546">
        <property type="protein sequence ID" value="KJB62546"/>
        <property type="gene ID" value="B456_009G422200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768186"/>
    <dbReference type="eggNOG" id="KOG2569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YVLVIGY"/>
    <dbReference type="OrthoDB" id="29657at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054103">
        <property type="entry name" value="CAND6-7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF2">
        <property type="entry name" value="RE59932P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21904">
        <property type="entry name" value="CAND6-7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252306" evidence="7">
        <location>
            <begin position="22"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="CAND6/7 N-terminal" evidence="9">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
        <location>
            <begin position="173"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB62546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="50098" checksum="5EC83ED5744A8DA1" modified="2015-04-29" version="1">MTKTTVILLFFFLSILSSATAEIKTLTIKSDSRPMILFEKFGFTHTGHVTISVSSVSVSSSSNAPNPSPSLLGFFLLSEESLLQVLLEIQQNSHFCVLNSRYIQHLFTFSELSPPPLSRLNRSYPVSSPNEYSLFFSNCAPETRVSMDVITEIYNLDRDGSKDYLSAGQKQLPSLYTVFSVLYLFFLAYWVYVCYTNRRCVHRIHLLMSGLLLFKALNLICAAEDKHYVKVTGTPHGWDVLFYIFQFIRVVLLFTVIVLIGTGWSFLKPFLQEREKKVLMIVIPLQVLANIASVVIGETGPFIKDWATWNQVFLLVDIICCCAIIFPIVWSIRSLRETSKTDGKAARNLAKLTLFRQFYIVVIGYLYFTRIVVFALRTIAAYKYQWVSNAAEETASLAFYLIIFYMFRPVEKNEYFILEEEDEEAAELALRDEDFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U711</accession>
    <name>A0A0D2U711_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_010G058400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U711"/>
    <dbReference type="STRING" id="29730.A0A0D2U711"/>
    <dbReference type="Gramene" id="KJB64629">
        <property type="protein sequence ID" value="KJB64629"/>
        <property type="gene ID" value="B456_010G058400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDIMEIV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="126"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB64629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="291" mass="33236" checksum="B951617348900E08" modified="2015-04-29" version="1">MNSELAKLGSSLLVPNVQELAKNPLKEVPPRYKLSSKEELEQLHYACKEWGFFQLINHGVSPSLVEKMKMETQEFFNLPMEEKKKAFVVSEEQKLNWGDMFYMVTLPTYLRKPHLETLEAYSVELKHLAMRLLEVMGKALGMDPNDLKPELSIGLNSHFDATGLTILLQINDMESLQIRKNGIWVPIKPLPNAFVINIRDIMEIVSNGIYRSIEHCATVNSVKERVSVATFYSPKLEGDMGSAPSLITPQTPPLFRRIGVADYFKGFFSRELHGKSYVDVFRLQNEEINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAW4</accession>
    <name>A0A0D2UAW4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_008G276600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAW4"/>
    <dbReference type="STRING" id="29730.A0A0D2UAW4"/>
    <dbReference type="Gramene" id="KJB52785">
        <property type="protein sequence ID" value="KJB52785"/>
        <property type="gene ID" value="B456_008G276600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765533"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLHQYTE"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF15">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 715, SUBFAMILY A, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58882" checksum="B479A0F69E31AFE6" modified="2015-04-29" version="1">MGVFLLFQIFFTIATISFSLHFFSTLIFSCWVLPIRAYKKIKKNGFTGPIPSFPMGNITEMKNSMNINVSSSLNVVSHDIHSTVFPYFARWQKSYGKLFIYWLGTEPFLYVAEPEFLKNMSAGVLGKSWGKPKVFKHDREPMFGSGLVMVEGDEWVRHRHVITPAFSPCNLKAMASLMVEPTTKMLDQWATLISSGYPEIDVEREITTTAGEIIARTSFGLSYQNGNKVFEKLRAMQITLFNSNRYVGVPFSKWMCPKKNLEAKRLGKEIDQLLLSIIDARKKSLDIGTSPQKDLLGLLMEGGLVDGRSGKSLTARELVDECKTFFFGGHETTALALTWTLLLLATYPDWQNQLRDEIKQVIGDGEIDFTKLADLKKMGWVMKEVLRLYSPAPNAQRQAREDIKVDDLVIPNGTNIWIDVVAMHHDPTLWGDDVNEFKPERFKDDPLYGGCKHKMGFLPFGFGGRMCVGKNLTTMEYKVIVTLMLTRFSFSLSSNYRHSPSILLSLRPRYGLPLLVKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEC4</accession>
    <name>A0A0D2UEC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="13">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_010G177300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Extracellular space</location>
            <location evidence="13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="13"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEC4"/>
    <dbReference type="STRING" id="29730.A0A0D2UEC4"/>
    <dbReference type="Gramene" id="KJB67139">
        <property type="protein sequence ID" value="KJB67139"/>
        <property type="gene ID" value="B456_010G177300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774700"/>
    <dbReference type="eggNOG" id="ENOG502QRCC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDNFNIM"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008264">
        <property type="entry name" value="Beta_glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00737">
        <property type="entry name" value="GLHYDRLASE16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="1 13" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112855" description="Xyloglucan endotransglucosylase/hydrolase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="14">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB67139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="294" mass="34449" checksum="88879F6E53C84C40" modified="2015-04-29" version="1">MEKGVLFIALLISAFYSSSEAADSQTSFEDNFSIMWSEDHFKTSEDGQTWYLSLDKETGCGFQTKQRYRFGWFSMKLKLVGGDSAGVVTAYYMCSENGAGPERDELDFEFLGNRTGQPYLMQTNVYKNGVGGREMRHMLWFDPTEEFHSYSILWNNHQIVFFVDEVPIRVFKNNGDEKNDFFPNEKPMYLFSSIWNADEWATRGGLEKTDWKRAPFVSSYKDFSVEGCQWEDPYPACVSTTTKNWWDQYKAWHLSDSQKMDYAWVQRNLVIYDYCKDNERYPKLPGECSLSPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEJ3</accession>
    <name>A0A0D2UEJ3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G183300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEJ3"/>
    <dbReference type="STRING" id="29730.A0A0D2UEJ3"/>
    <dbReference type="Gramene" id="KJB67204">
        <property type="protein sequence ID" value="KJB67204"/>
        <property type="gene ID" value="B456_010G183300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1646">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHAHDYH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268469" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB67204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="126" mass="14166" checksum="2D5A2EC75F16E8BD" modified="2015-04-29" version="1">MHFASISFHCCFFVPLPILCSSSPLKKSLVLCSSSPPPVTSQETNLVARCRRVYDHAHDYHINSISNNRSRNQEIGFRSGEIKGNKVSKAPKIQRLATPLTLQRKLTRIAEKKKKITKAKAEAAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEN7</accession>
    <name>A0A0D2UEN7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_009G015800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Required for pathogen-associated molecular pattern (PAMP, e.g. chitin and flg22)-triggered immunity (PTI) involving reactive oxygen species (ROS) accumulation and triggering plant defense, including defense-related gene expression (e.g. PR1 and LOX). Ensures specific recognition of the EPD1 effector of Verticillium dahliae, resulting in a hypersensitive response known as effector-triggered immunity (ETI), characterized by the activation of programmed cell death to limit infection by the pathogen. Priming plants with the incompatible pathogen V.dahliae leads to an increased resistance to compatible pathogens, as a result of systemic acquired resistance (SAR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEN7"/>
    <dbReference type="SMR" id="A0A0D2UEN7"/>
    <dbReference type="Gramene" id="KJB54000">
        <property type="protein sequence ID" value="KJB54000"/>
        <property type="gene ID" value="B456_009G015800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771186"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYSCLHR"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000258">
        <property type="entry name" value="Probable serine/threonine-protein kinase PBL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0928">Hypersensitive response elicitation</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0611">Plant defense</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="95"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="391"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="391"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="429" mass="47926" checksum="ECDE50857EA655C0" modified="2015-04-29" version="1">MADNNCDCWTFLKRGVCNSSSSTTHSANTIPRTSLVYDAATETRCLNASNRELFPPNEARLSSDNLDPPTSTKTKSPRQLLQFTFQELKSATGNFRPDSILGEGGFGYVFKGWIEENGTAPAKPGSGITVAVKSLKLDGLQGHREWVVEVAFLGQLHHPNLVKLIGYCIEEDHRLLVYEFMTRGSLENHLFRRTIPLPWSNRIKITLGAAKGLAFLHGGPEPVIYRDFKTSNILLDSEYNAKLSDFGLAKAGPQGDKTHVSTRVVGTYGYAAPEYVMTGHLTSKSDVYSFGVVLLEILTGRRSMDKKRPSGEQNLVTWARPYLADKRKLYQLVDPRLELNYSLKGVLKVSQLAYSCLHRDPKARPTMDEVVKVLSQLQDLNDLAILSHHSRLSQQGRRKKKPEGSKSTKDSPLNIGKHRKDEIKLQLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ95</accession>
    <name>A0A0D2UJ95_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Squalene cyclase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G2233002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ95"/>
    <dbReference type="STRING" id="29730.A0A0D2UJ95"/>
    <dbReference type="Gramene" id="KJB68050">
        <property type="protein sequence ID" value="KJB68050"/>
        <property type="gene ID" value="B456_010G2233002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68051">
        <property type="protein sequence ID" value="KJB68051"/>
        <property type="gene ID" value="B456_010G2233002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68052">
        <property type="protein sequence ID" value="KJB68052"/>
        <property type="gene ID" value="B456_010G2233002"/>
    </dbReference>
    <dbReference type="OMA" id="TYHSIFP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042300">
        <property type="term" value="F:beta-amyrin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF48">
        <property type="entry name" value="TERPENE CYCLASE_MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395598" description="Squalene cyclase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB68051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="155" mass="17343" checksum="3928ACDE8601B791" modified="2015-04-29" version="1" fragment="single">YGCWGICFFYGTWFALSGLKAAGKNFKNCLAIRKGVEFLLKTQREDGGWGESYLSCPKKVYTPIEGKESNLASTAQALMGLIIGGQAERDPTPLHRAAKLLINSQLPNGDFPQQGLAAVFMRNCLLHFALYRNIFPLWALAEYRNHVWPSKHVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKM6</accession>
    <name>A0A0D2UKM6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G120200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKM6"/>
    <dbReference type="STRING" id="29730.A0A0D2UKM6"/>
    <dbReference type="Gramene" id="KJB56450">
        <property type="protein sequence ID" value="KJB56450"/>
        <property type="gene ID" value="B456_009G120200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767622"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HILPWAT"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11043">
        <property type="entry name" value="CYP90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000022">
        <property type="entry name" value="Taxadiene 5-alpha hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF297">
        <property type="entry name" value="BETA-AMYRIN 28-OXIDASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB56450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54224" checksum="9BB55799D05B339F" modified="2015-04-29" version="1">MDPILLFFATFFPLLSLAFLIFYKKSNYASNPNLPPGRMGFPYIGESIEYLLTGRRGHPEKFLKDRMAKYSSQVFKTSIFGEPMAVVCGAVGNKFLFSNENKLVTSWWPDSVNKIFPSSTQTSSKEESIKMRKMLPNFLKPEALQRYIGMMDMIAQRHFEASWEGKQEITVFPLAKRYTFWVACKVFLSIEDPVHVSKLADLFNALAAGIITVPIDLPGTPFRRAINAAETTRKELMAIIKQRKMDLAENKATPDQDILSHMLLATDEKGQYLNELNIADRILGLLIGGHDTASATVTFIVKYLAELPNIYNEVYKEQMEIARSKKEGEMLNWEDIKKMKYSWNVACEVMRLAPPLQGAFREAITDFTFAGFSIPKGWKLHWNVNSTHKNPECFPEPEKFEPARFEGSGPAPYTFVPFGGGPRMCPGKEYARLEILVFMHNVIKRFNWEKLIPDEMIIVDPLPMPAKGLPVRLLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USL9</accession>
    <name>A0A0D2USL9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G134000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USL9"/>
    <dbReference type="SMR" id="A0A0D2USL9"/>
    <dbReference type="STRING" id="29730.A0A0D2USL9"/>
    <dbReference type="Gramene" id="KJB71619">
        <property type="protein sequence ID" value="KJB71619"/>
        <property type="gene ID" value="B456_011G134000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB71620">
        <property type="protein sequence ID" value="KJB71620"/>
        <property type="gene ID" value="B456_011G134000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776359"/>
    <dbReference type="eggNOG" id="KOG0102">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENAKCEL"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10234">
        <property type="entry name" value="ASKHA_NBD_HSP70_DnaK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000001">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="662"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB71619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="706" mass="75708" checksum="4E928CA187BACE4C" modified="2015-04-29" version="1">MASSTAQIHVLGGIGFASSRKPNHHSPRTVFLGQRLNKTSPLNAAFLRLAKTNNNGKRYSVGPVRVVNEKVVGIDLGTTNSAVAAMEGGKPTIVTNAEGQRTTPSVVAYTKTGDRLVGQIAKRQAVVNPENTFFSVKRFIGRKMSEVDEESKQVSYKVIRDDNGNVKLDCPAIGKQFAAEEISAQVLRKLVDDASKFLNDKVTKAVVTVPAYFNDSQRTATKDAGRIAGLEVLRIINEPTAASLAYGFEKKNNETILVFDLGGGTFDVSVLEVGDGVFEVLSTSGDTHLGGDDFDKRIVDWLAENFKRDEGIDLLKDKQALQRLTETAEKAKMELSSLTQANISLPFITATADGPKHIETTITRVKFEELCSDLLDRLKTPVENSLRDAKLSFKDIDEVILVGGSTRIPAVQELVRKMTGKEPNVTVNPDEVVALGAAVQAGVLSGDVSDIVLLDVSPLSLGLETLGGVMTKIIPRNTTLPTSKSEVFSTAADGQTSVEINVLQGEREFVRDNKSLGSFRLDGIPPAPRGVPQIEVKFDIDANGILSVTAVDKGTGKKQDITITGASTLPNDEVDRMVKEAEKFSKEDKERRDAIDTKNQADSVVYQTEKQLKELGDKVPGPVKEKVEAKLQELRDAISGGSTQGMKDAMAALNQEVMQLGQSLYNQPGAAGGPGGPAPGGETGPSDSSNKGPDGDVIEADFTDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UUL2</accession>
    <name>A0A0D2UUL2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G156600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UUL2"/>
    <dbReference type="Gramene" id="KJB72071">
        <property type="protein sequence ID" value="KJB72071"/>
        <property type="gene ID" value="B456_011G156600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778212"/>
    <dbReference type="eggNOG" id="ENOG502QU8F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WANFTKT"/>
    <dbReference type="OrthoDB" id="1868374at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF44">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB72071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="451" mass="49868" checksum="9B24118E42681380" modified="2015-04-29" version="1">MIGIKDLYSVLTAVVPLYVTMFLAYGSVKWWNVFTPEQCAGINRFVAIFAVPLLSFEFVSRINPYKMDLLFLAADGVSKVLILFALLCWANFTKTGGLDWSITVFSLSTLPNTLVMGIPLLKSMYGDDKEYLMIQVVVLQCIIWYTLLLFLFEYRETRTEVLSKFKESSVSSKNCCSEDEVIDVIATISSNQQQQQQQTAQNANKIAPDQSQRFRPMVAASMEGEGKELHLFIWRCGCCISTDGTSTTCEKQSVQAGQREESSSTAKVVESVKQEDVENASIPSSFSSSMLLKILRKVWLKLVRNPNSYSSLLGLSWALVSCRWDIKKPQIMENSVTILSSAGLGMAMFSLGLFMALQPRIIACGKKLALYGMVARFIAGPAVMAIASIAVGLKGTTLKLSIVQAALPQGIVPFVFSREYNLHPDVLSTAVIFGMIVSLPITIVYYILLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXU0</accession>
    <name>A0A0D2UXU0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G249500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXU0"/>
    <dbReference type="STRING" id="29730.A0A0D2UXU0"/>
    <dbReference type="Gramene" id="KJB73761">
        <property type="protein sequence ID" value="KJB73761"/>
        <property type="gene ID" value="B456_011G249500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HASIQED"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128:SF46">
        <property type="entry name" value="ALPHA-LATROTOXIN-LHE1A-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24128">
        <property type="entry name" value="HOMEOBOX PROTEIN WARIAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="246"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="457" mass="51961" checksum="CAA6F429FFF94A62" modified="2015-04-29" version="1">MDENLRKAARTGKVNELYRVIQRNGNVLRRVDEVEFIDTPLHIAAEEGCIEFEPTSHKEMALRFLEIDKQLIRVRGKKGKTPLHYLCKVGNQLGLLDTFLEASPDCIQDVTIENRTALHIAIQNNRLDVLQLLIRTLKRKDYYWEVVNWKDKDGSTALHIAATHDQPQMLKLLLDCKADKHATNQVGWTALVIAQRHNNRENIAILQGSFIPVVSNFKRKLEKHVVKYVTKASLLIFQNMDNISADDRNALLVILGLLLTATYQATLSPPGGVWQGENTSKSKGSFDKWVLGKSVMNQSSFLLFYIPTYLVFLVTLFLTLALLKTFPREFRTALQVLLAFLAVSFDGSISYIAPTNLAYVILNIFSGILFLLMLSMCIVCRVSKISVSIVGCWIFPSILEFWKGTIFVVCYCLFVSIDIFGKGISHWYLAAFIVCWLFLSLGRLCIMRRTQFCNTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXU2</accession>
    <name>A0A0D2UXU2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G334200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXU2"/>
    <dbReference type="STRING" id="29730.A0A0D2UXU2"/>
    <dbReference type="Gramene" id="KJB60990">
        <property type="protein sequence ID" value="KJB60990"/>
        <property type="gene ID" value="B456_009G334200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765919"/>
    <dbReference type="eggNOG" id="ENOG502QTQU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2017864at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43592:SF7">
        <property type="entry name" value="CAAX AMINO TERMINAL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="193"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB60990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="32103" checksum="C2111D8D1A93AD17" modified="2015-04-29" version="1">MGLLTINCGMFVRYYGIQEFSPRISIISTKFSARAFASRKPMKISRREGRLSKSFTLQTKETLPEDINGLADMCPSKDGNNNNGKSVDSTPPDIISIPSRSNVLQACTITSGLIAALGLIIRQVSHVGSMEGLPILDCSTEVSFGFELWHLELITGLVLLISSCRYILLKTWQYFAESSDTANKQVLSSLQPYDYLVVAFLPGMSEELLFRGALLPVLGFDWKSVMVVSTVFGVLHLGNGRKYSFAVWATFVGIVYGYATIMSSSVIVPMASHALNNLVGGLLWRYTSKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UY53</accession>
    <name>A0A0D2UY53_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G343400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UY53"/>
    <dbReference type="Gramene" id="KJB61150">
        <property type="protein sequence ID" value="KJB61150"/>
        <property type="gene ID" value="B456_009G343400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268947" evidence="1">
        <location>
            <begin position="22"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="121" mass="13395" checksum="1C59A0FCFC614589" modified="2015-04-29" version="1">MKIALVVFSLALVLSIIVGDAADIKLTPEQEKKIGDELEDAFLIGVAKGLSQSGVKISPKQEEKILSEMLIHLVKEFLDPIQPGIAEKAMESSKAKTMLAELIQKLRIKRNESENKGRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYJ6</accession>
    <name>A0A0D2UYJ6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G271500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB74091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2UYJ6"/>
    <dbReference type="Gramene" id="KJB74091">
        <property type="protein sequence ID" value="KJB74091"/>
        <property type="gene ID" value="B456_011G271500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31719:SF209">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 68-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31719">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR 56"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAM"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAC"/>
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    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB74091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="322" mass="36827" checksum="AAF73254A2E27C4F" modified="2015-04-29" version="1" fragment="single">MEEKDEACLRSIPPGYRFKPRDDEIINFYLRPKIFGLPLPPNRIKEVFLYNYDPQTLTAMSNNALSNGVGNEYYFFTPRDRKYANGSRPARNAGNGYWKATGADKLICRKGKKIGLKKSLVFYQGKPPKGVKTNWLMHEYVLTDAPIRKRLGNEDMRLDDWVLCRVYKNPRVKKLEHETLEDGNQEEADTATTVAYDGAQMVQQEGHQVECEAEAARSAIPPYNGIQMVENGIAFAPLYEPINTSSQMLENGIAFAPLYEPINVQMPQGTSFWFPEQVYSTPYFNQYGDYTFEHPTLEGFNMPDCGVSDPAHFQINMQQHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VB28</accession>
    <name>A0A0D2VB28_GOSRA</name>
    <protein>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G161200</name>
    </gene>
    <organism evidence="2 3">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2VB28"/>
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        <property type="gene ID" value="B456_010G161200"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Beta Polymerase, domain 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="174" mass="19879" checksum="AF5243984804EA27" modified="2015-04-29" version="1">MLKRRRSDILMLNSPLLAIYESLIPPVEEKAKQKQLLALLEKLVCKEWPEAWLYLYGSCENSFEVSKREIDNCLAFNEDIHDKSEILLKLADILQSDTLQNVQALTRARVPIVKLMDPVTGISCDTRKQCLGCSKYKASTRLCKDRCKITAVGFYCETLGQVHRSECNLPRNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VBY2</accession>
    <name>A0A0D2VBY2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Aminoalcoholphosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_013G102300</name>
    </gene>
    <organism evidence="23 24">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="20">Catalyzes both phosphatidylcholine and phosphatidylethanolamine biosynthesis from CDP-choline and CDP-ethanolamine, respectively. Has a higher cholinephosphotransferase activity than ethanolaminephosphotransferase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>CDP-choline + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32939"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58779"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>CDP-ethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32943"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57876"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.7.8.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VBY2"/>
    <dbReference type="STRING" id="29730.A0A0D2VBY2"/>
    <dbReference type="Gramene" id="KJB80530">
        <property type="protein sequence ID" value="KJB80530"/>
        <property type="gene ID" value="B456_013G102300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80531">
        <property type="protein sequence ID" value="KJB80531"/>
        <property type="gene ID" value="B456_013G102300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80532">
        <property type="protein sequence ID" value="KJB80532"/>
        <property type="gene ID" value="B456_013G102300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80533">
        <property type="protein sequence ID" value="KJB80533"/>
        <property type="gene ID" value="B456_013G102300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784082"/>
    <dbReference type="eggNOG" id="KOG2877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FITRQIC"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004307">
        <property type="term" value="F:ethanolaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000014">
        <property type="entry name" value="Choline/ethanolaminephosphotransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00050328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00050476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00055748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB80531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43249" checksum="9EE2EFD3F7B88D9E" modified="2015-04-29" version="1">MGYIGAHGIAALHRYKYSGVDHSYLAKYVLQPFWNRFVNFFPLWMPPNMITLTGFMFLVLSALLGYVYSPRLDSPPPRWVHLAHGLLLFLYQTFDAVDGKQARRTNSSSPLGELFDHGCDALACAFETMAFGSTAMCGGDSFWFWVISSIPFYGATWEHYFTNALILPVVNGPTEGLALIYGLHFMTAIVGAQWWAQPFQQSIPFLSWIPYVNELPTYKAAVYLLTPIAILPTVACNISNVHKVVKARKGSMLLALAMLYPFVVLMGGVLIWDHLSPSDVMGNYPHLVILGTGLAFGFLVGRMILAHLCDEPKGLKTNMCMSLLYLPLAIANALTARLNDGVPLVDEFLVLLGYCVFTGSLYCHFSTSVIHEITTALGIYCFRITRKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH35</accession>
    <name>A0A0D2VH35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7866 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G179900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2VH35"/>
    <dbReference type="Gramene" id="KJB82179">
        <property type="protein sequence ID" value="KJB82179"/>
        <property type="gene ID" value="B456_013G179900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784335"/>
    <dbReference type="eggNOG" id="ENOG502S5VF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1871192at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057188">
        <property type="entry name" value="DUF7866"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33786">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33786:SF2">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25268">
        <property type="entry name" value="DUF7866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269272" description="DUF7866 domain-containing protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7866" evidence="2">
        <location>
            <begin position="58"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB82179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="110" mass="12160" checksum="F0C7BCDD3E15C1CE" modified="2015-04-29" version="1">MKSGYGVTLFLLFLFFSAFFFNYNEATSMAQVNGSSEMFPLVEEKMMLFNESRRKLGSFQICAVCTCCGGAKGACLPSPCCYAINCNIPNRPFGFCSFTPKTCNCFGCHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHM7</accession>
    <name>A0A0D2VHM7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G233900</name>
        <name evidence="9" type="ORF">Gorai_003589</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0603446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHM7"/>
    <dbReference type="STRING" id="29730.A0A0D2VHM7"/>
    <dbReference type="Gramene" id="KJB83181">
        <property type="protein sequence ID" value="KJB83181"/>
        <property type="gene ID" value="B456_013G233900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB83182">
        <property type="protein sequence ID" value="KJB83182"/>
        <property type="gene ID" value="B456_013G233900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB83183">
        <property type="protein sequence ID" value="KJB83183"/>
        <property type="gene ID" value="B456_013G233900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782800"/>
    <dbReference type="eggNOG" id="KOG0714">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000065">
        <property type="entry name" value="Chaperone protein dnaJ 49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="126"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB83181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0603446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="375" mass="41669" checksum="598C99533AE7AB5A" modified="2015-04-29" version="1">MDGNKDDALKCLKIGKDALDAGDRARALKFLTKARRLDPSLPIENLLSAAEGGKSDDQPASEPVGSAKDPSGSSPSKSSDQPSIRRRNIPNGSAASASASSPASAAGGTYTEEQIVIVKQIRKKKDYYEILGLEKSCSVDDIRKAYRKLSLKVHPDKNKAPGAEEAFKAVSKAFQCLSNEESRKKYDLVGSDEPVYERRASPFRGGGNGFSGFYDTDFDADEIFRNFFFGGMPPATTQFRSFNFGPGMGARMGDQGSTGFNIRMLIQLLPVLLILLFSFLPSSEPVFSLSRSYPYEYKFTTKNGVNYYVRSTKFEQDYPTNSVERVRIEERVERDYYSVLAQNCRFELQRQQWGFIRETPHCDLLEKFQSAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ89</accession>
    <name>A0A0D2VJ89_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G232400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ89"/>
    <dbReference type="Gramene" id="KJB83164">
        <property type="protein sequence ID" value="KJB83164"/>
        <property type="gene ID" value="B456_013G232400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1444">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIFRRQP"/>
    <dbReference type="OrthoDB" id="417037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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            <begin position="12"/>
            <end position="32"/>
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            <end position="64"/>
        </location>
    </feature>
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        </location>
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            <begin position="133"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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        </source>
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        </source>
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    </evidence>
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        <source>
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    <sequence length="345" mass="37993" checksum="76AD8D16465DE860" modified="2015-04-29" version="1">MSAIRFEPTKQYYATTSLVVGYALCSSFLAVINKFAITKFNYPGLLTALEYITSALGVWVLGKFGFLHHDPFKLDIANKFLPAAVVFYLAIFTNTNLLRHANVDTFIVFRSLTPLLVALADTIFRRQPCPSKLTFMSLLIILGGAVGYVATDSAFTLTAYSWAFAYLVTITTEMVYIKHMVMNLGLNTWGFVLYNNFLSLMMAPIFWVLTGEYNEVFAALIANGGNWFEPVAFTGVSLSCLFGMLISFFGFATRKAVSATAFTVTGVVNKFLTVMINVLIWDKHATPFGLVCLLFTLSGGVLYQQSVTGPPPHDSTASKQTGDASDNDDHEDNQDKKMPGKHASI</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="145" mass="16773" checksum="F19CB0EBB45F05BD" modified="2015-04-29" version="1">MENLWRAATGQDPNPDDYKGVEFWTNPERAGWLTKQGDYIKTWRRRWFILKQGKLLWFKDPTSVSRRSSPRGVVSVGSCLTVKGAEDIVNKAFAFELSTRDSTMYFIADTEKEKEDWINSIGRSIVQHSRSVTDSEIVDYDSKSR</sequence>
</entry>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35109:SF1">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="107" mass="12090" checksum="2C8FB02F9B5589EA" modified="2015-04-29" version="1">MGRAAFTKTKILMLREAKRVERPLSKIAGADREINKKCKSNNDIKGSSSWVPHPKSGIYFPKGHEWVMDDVPDRAASFSSSYWVRSVDGVDKPESSVHDEHYSHANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W4A5</accession>
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            <fullName evidence="5">DUF538 domain-containing protein</fullName>
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    <gene>
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        <name evidence="2" type="ORF">Gorai_002627</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 4" key="2">
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
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        <source>
            <strain evidence="2">8</strain>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>heme</name>
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        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
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        <location>
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        <ligand>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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        <lineage>
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            <taxon>Pentapetalae</taxon>
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        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W946"/>
    <dbReference type="STRING" id="29730.A0A0D2W946"/>
    <dbReference type="Gramene" id="KJB83375">
        <property type="protein sequence ID" value="KJB83375"/>
        <property type="gene ID" value="B456_013G244600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782720"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFVRINI"/>
    <dbReference type="OrthoDB" id="964595at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013838">
        <property type="entry name" value="Beta-tubulin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00228">
        <property type="entry name" value="TUBULIN_B_AUTOREG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="449" mass="49748" checksum="0095CA59973E89F4" modified="2015-04-29" version="1">MREIISIHIGQAGIQVGNSCWELYCLEHEIQPDGMMPSDTSVGVANDAFNTFFSETGSGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRVRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIYPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLISQIISSLTTSLRFDGAINVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSIPEITNAVFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTVQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNNTAVAEVFARIDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGVEDEEDAEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WAB0</accession>
    <name>A0A0D2WAB0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_N008400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204121">
        <property type="protein sequence ID" value="KJB84175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WAB0"/>
    <dbReference type="STRING" id="29730.A0A0D2WAB0"/>
    <dbReference type="Gramene" id="KJB84175">
        <property type="protein sequence ID" value="KJB84175"/>
        <property type="gene ID" value="B456_N008400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB84175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="82" mass="9186" checksum="2C132F7E8074842B" modified="2015-04-29" version="1">MVHSMAITEDGALFYWVSSDPHLRCQQLYSLCKKTIVSISAGKYWAATATAIGDVYMWDGKKSMDKPPVATRLHRVKGKKIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M164</accession>
    <name>A0A0D2M164_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_001G204900</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Page J.T."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
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                <person name="Zhang L."/>
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                <person name="Reddy U.K."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
            <location evidence="8">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
        <text evidence="8">SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M9Q4"/>
    <dbReference type="SMR" id="A0A0D2M9Q4"/>
    <dbReference type="STRING" id="29730.A0A0D2M9Q4"/>
    <dbReference type="Gramene" id="KJB14267">
        <property type="protein sequence ID" value="KJB14267"/>
        <property type="gene ID" value="B456_002G116800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783742"/>
    <dbReference type="eggNOG" id="KOG3172">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="7"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB14267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="132" mass="14396" checksum="2E59F97BCABDAF22" modified="2015-04-29" version="1">MSRSLGIPVKLLHEASGHIVTVELKSGELYRGSMVECEDNWNCQLENITFTAKDGKVSQLEHVFIRGSKVRFMVIPDMLKNAPMFKRLDAKIKGKSSSLGVGRGRAVAMRAKAQAAGRGTTAGRGVVPSIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MHT6</accession>
    <name>A0A0D2MHT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Oxidoreductase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G011700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MHT6"/>
    <dbReference type="STRING" id="29730.A0A0D2MHT6"/>
    <dbReference type="Gramene" id="KJB17712">
        <property type="protein sequence ID" value="KJB17712"/>
        <property type="gene ID" value="B456_003G011700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787500"/>
    <dbReference type="eggNOG" id="KOG4690">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSHITQD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019180">
        <property type="entry name" value="Oxidoreductase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039251">
        <property type="entry name" value="OXLD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21193:SF3">
        <property type="entry name" value="OXIDOREDUCTASE-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09791">
        <property type="entry name" value="Oxidored-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidoreductase-like" evidence="2">
        <location>
            <begin position="103"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB17712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="155" mass="17320" checksum="9A54CE547F440274" modified="2015-04-29" version="1">MPTHSYHQFPPTFLNQSPPTDKLINTQSRVGHSMTIIKHPTSTTLRFLSSINSRRFQYPRRRFLLVNGSVRFKPMATKLEETMIKGAGEDSKKGGKGEEPGKGIQPPPPPPEKPEPGDCCGSGCVRCVWDVYYEELEAYNKLYKSDSNGSKSNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N0J2</accession>
    <name>A0A0D2N0J2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G189200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N0J2"/>
    <dbReference type="Gramene" id="KJB25392">
        <property type="protein sequence ID" value="KJB25392"/>
        <property type="gene ID" value="B456_004G189200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791974"/>
    <dbReference type="OMA" id="PIAHRIY"/>
    <dbReference type="OrthoDB" id="980916at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021:SF8">
        <property type="entry name" value="FIBER PROTEIN FB17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB25392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="167" mass="18556" checksum="77EA061E695DE4B0" modified="2015-04-29" version="1">MEQLNANVKSEVDYSHFEILEKGLGKDLIMVGRFNVPLRLAPIADRIYDIYGDITASSTQSDCAAKPSYILFCAAIKEMDDLKLDQVNETKILLWRDAINNAHNLQFGVGFAIEHLKRIARAYIGFKAILKTCSTTKMDSSRIVSVQLNISWASLLASVCSISIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N5Y9</accession>
    <name>A0A0D2N5Y9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gamma carbonic anhydrase-like 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G057800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N5Y9"/>
    <dbReference type="STRING" id="29730.A0A0D2N5Y9"/>
    <dbReference type="Gramene" id="KJB07993">
        <property type="protein sequence ID" value="KJB07993"/>
        <property type="gene ID" value="B456_001G057800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQV5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd04645">
        <property type="entry name" value="LbH_gamma_CA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047324">
        <property type="entry name" value="LbH_gamma_CA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050484">
        <property type="entry name" value="Transf_Hexapept/Carb_Anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061">
        <property type="entry name" value="DYNACTIN SUBUNIT P25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13061:SF29">
        <property type="entry name" value="GAMMA CARBONIC ANHYDRASE-LIKE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27088" checksum="4F7BBF400B7441A1" modified="2015-04-29" version="1">MATSIAARISRKAAASAFSAHRHVISSRCFATESAKTISPSSDRVKWDYRGQRKIIPLGQWVPKVAVDAYVAPNVVLAGQVTVYDGASVWSGCVLRGDLNKITVGFCSNVQERCVIHAAWSSPTGLPAETSIERFVTIGAYSLLRSCTIEPECIIGQHSILMEGSLVETHSILEAGSVVPPGRRIPTGELWAGNPARFVRALTHEETLEIPKLAVAINDLSKEHFSEFLPYSTVYLEVEKLKKSLGINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NG97</accession>
    <name>A0A0D2NG97_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G212900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NG97"/>
    <dbReference type="STRING" id="29730.A0A0D2NG97"/>
    <dbReference type="Gramene" id="KJB31832">
        <property type="protein sequence ID" value="KJB31832"/>
        <property type="gene ID" value="B456_005G212900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB31833">
        <property type="protein sequence ID" value="KJB31833"/>
        <property type="gene ID" value="B456_005G212900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB31834">
        <property type="protein sequence ID" value="KJB31834"/>
        <property type="gene ID" value="B456_005G212900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794987"/>
    <dbReference type="eggNOG" id="KOG0724">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHCNNDS"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000009">
        <property type="entry name" value="transcription factor MYB1R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000154">
        <property type="entry name" value="Transcription factor SRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042:SF66">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="7"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="115"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="123"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="187"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="290" mass="31154" checksum="CAC2BB013A5633D1" modified="2015-04-29" version="1">MTVEEAVNSSEWSREQDKAFENALATYPEDSLDRWEKIAADVPGKTLEEIKEHYELLEDDVNRIVSGCVPLPPYNSFEGSTGHAGDEGTGKKGSCHLGHCNNDSNHGSKNSRSDQERRKGIAWTEDEHRLFLLGLEKYGKGDWRSISRNFVVTRTPTQVASHAQKYFIRLNSMNKDRRRSSIHDITSVGNGDIASQGPITGQSNGAAAGGSSAKSAKQTSRHPASPPGVGMYGAPTIGQPVGGPLVSAVGRPVNLPASAHMGYGVTVPGAPMNMGPATYPMPHSTAHSHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NI91</accession>
    <name>A0A0D2NI91_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G257200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NI91"/>
    <dbReference type="STRING" id="29730.A0A0D2NI91"/>
    <dbReference type="Gramene" id="KJB32707">
        <property type="protein sequence ID" value="KJB32707"/>
        <property type="gene ID" value="B456_005G257200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4GQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IVMEAFN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31175">
        <property type="entry name" value="AUXIN-RESPONSIVE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31175:SF65">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN SAUR66-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16465" checksum="EA8BBF74D68333FA" modified="2015-04-29" version="1">MVRAKKLINLARKWQKMAAIRRKRITSPSATSDTDANSCSTSTAVEQGHFVVYSVDQKRFVLPLEYLKNEIVMEAFNLAGEEFGLSGNKALILPCDATFMEYVIALIKRKPSKDVEKALILSVASGRCSSSYLYQQETSLQLPLWSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NRV9</accession>
    <name>A0A0D2NRV9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G131900</name>
        <name evidence="3" type="ORF">Gorai_000896</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NRV9"/>
    <dbReference type="Gramene" id="KJB35882">
        <property type="protein sequence ID" value="KJB35882"/>
        <property type="gene ID" value="B456_006G131900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799442"/>
    <dbReference type="eggNOG" id="ENOG502S5RY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEDHNDW"/>
    <dbReference type="OrthoDB" id="1917400at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34666:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34666">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB35882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0587775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="174" mass="19878" checksum="8B28B6C085CA0940" modified="2015-04-29" version="1">MATTEEFSFPTFTDLYPCSIDSPPLWHLSPAASPDVFLHSKGKQEEEDCFPVSQRADEDDHQERKSKSHEDHNDWKQSDKGVAEDEEEDEEEKMDMLWEDFNEEELPRSGSSSRCSEDMVEMGCGGGHSLKLSKTNVGMFSPSPRRAGMLVFMRVLRKFLLHNSHRSSNSHLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NTG5</accession>
    <name>A0A0D2NTG5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G158400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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                <person name="Byers R."/>
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                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Zhang L."/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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</entry>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
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        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
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        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
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    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="75"/>
            <end position="132"/>
        </location>
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        </location>
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        <source>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697:SF230">
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    </dbReference>
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            <dbReference type="EMBL" id="KJB22968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16731"/>
            <dbReference type="ChEBI" id="CHEBI:33227"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.195"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:10394"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; phenylpropanoid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PDA2"/>
    <dbReference type="STRING" id="29730.A0A0D2PDA2"/>
    <dbReference type="Gramene" id="KJB43827">
        <property type="protein sequence ID" value="KJB43827"/>
        <property type="gene ID" value="B456_007G218300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803968"/>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTGWDQY"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045551">
        <property type="term" value="F:cinnamyl-alcohol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000100">
        <property type="entry name" value="Putative cinnamyl alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0438">Lignin biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB43827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0590553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="352" mass="38180" checksum="F9223D4FC2753F11" modified="2015-04-29" version="1">MEGRRVIGWAARDVSAHLSPYSFTLRKTGPEDVVLKVLYCGVDHTDLHQMRGELMPINYPLVPGHEVVGEVVEVGSEVNKFKLGDKVGVGCLISSCGKCLSCNSNNEQYCNQRVFTYGAVNKDGTPTHGGFSSAMVVHQKFVVQIPEKLAPEQAAPLLCAGVTAYSPLKQFNNSDKAIKAGILGLGGVGHLAVLIAKAMGHHVTVISSSENKKVEALEHLHADAFLVSSNAAEMEGAAASLDYILDTVPAFHSLEPYISLLKAGGKLTFVGVSTKPLHFNNDELILGNKSLTGSFIGSMEETQEILDFWAEKGLSTMIEVVKMDYINKAFERLKRNDVRYRFVLEVAGSNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PEW7</accession>
    <name>A0A0D2PEW7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G256000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PEW7"/>
    <dbReference type="STRING" id="29730.A0A0D2PEW7"/>
    <dbReference type="Gramene" id="KJB44502">
        <property type="protein sequence ID" value="KJB44502"/>
        <property type="gene ID" value="B456_007G256000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSELACT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008352">
        <property type="term" value="C:katanin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845">
        <property type="entry name" value="KATANIN P80 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19845:SF0">
        <property type="entry name" value="KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="2"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB44502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="150" mass="16575" checksum="81753927B1D9C7D3" modified="2015-04-29" version="1" fragment="single">SLSGHTSGIDSVTFDSPEVLVAAGAASGTIKLWDLDEAKIVRTLTGHRSNCISMDFHPFGEFFASGSLDTNLKIWDIRKKGCIHTYKGYTQGVNAIRFTPDGRWVVSGGEDNIVKVWDLTAGKLLHQFKDHEGQIQCLDFHPHEFLLATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PG67</accession>
    <name>A0A0D2PG67_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FLZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G217100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FLZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PG67"/>
    <dbReference type="STRING" id="29730.A0A0D2PG67"/>
    <dbReference type="Gramene" id="KJB25938">
        <property type="protein sequence ID" value="KJB25938"/>
        <property type="gene ID" value="B456_004G217100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792269"/>
    <dbReference type="OMA" id="MYGDFRA"/>
    <dbReference type="OrthoDB" id="1864056at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007650">
        <property type="entry name" value="Zf-FLZ_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33059">
        <property type="entry name" value="FCS-LIKE ZINC FINGER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33059:SF76">
        <property type="entry name" value="FCS-LIKE ZINC FINGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04570">
        <property type="entry name" value="zf-FLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51795">
        <property type="entry name" value="ZF_FLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FLZ-type" evidence="7">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FLZ-type" evidence="6">
        <location>
            <begin position="67"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB25938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="118" mass="13445" checksum="1E149D3767DB9448" modified="2015-04-29" version="1">MKRSRSSSFGNIRVLKSPPPTAFGFQWNTRANATVISVHAPPKAREMTKVGILAVSAPKLAVWQESYFLDNCFLCKKGLRQNDIRFMYGDFRAFCSIECRHKQITEDAEKEKASKEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJ62</accession>
    <name>A0A0D2PJ62_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G270600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the disease resistance NB-LRR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJ62"/>
    <dbReference type="STRING" id="29730.A0A0D2PJ62"/>
    <dbReference type="Gramene" id="KJB26993">
        <property type="protein sequence ID" value="KJB26993"/>
        <property type="gene ID" value="B456_004G270600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792798"/>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHEIPTD"/>
    <dbReference type="OrthoDB" id="1926275at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050905">
        <property type="entry name" value="Plant_NBS-LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463:SF212">
        <property type="entry name" value="AND NB-ARC DOMAINS-CONTAINING DISEASE RESISTANCE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33463">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="162"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB26993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="981" mass="111588" checksum="BE1A8038B6EC3726" modified="2015-04-29" version="1">MEVLGPILEIVHIMLDPIAKYFKYHRGVKKYMMILHKKLEELKCRKDDIESRLNIDLLQSGKTLKKEVQLWLDGACKIISQVDSLSKEVGDMKYLSRAHFGKKITVTIKVVDEHHRKGDFVDRLVIDAPTGNKVTLPTTELVGKSTARRNMEQLWDCLMDDSCRKIGVYGMGGVGKTTMIKLIHNRLLEETNKFDNVIWVSVSKFASVTQLQDKLARAIGVCMPENESEMVRAAKLFAMIQTMKNCVLIFDDVWEAFQLEDVGIPEPGADNKSKFVLTTRLADVCLRMGCKQIKAELLSEEEAWNLFVEKASLDVISPHIKPIAKEVAKQCACLPLAIVTIARSLKGVTESCEWRNALEELRDSTRGHHDMRRVLEQLKFSYNHLDDEKLRNCLLYCALYPEDFSIRRKELIERLIAGGVIDRMCSRRAAFDKGHAMLNKLEKACLLECVMKKSEDNKQVKMHDLVRDMVIHVNGISSRLMVKSGMHLREIPDGNYWTEDLEMVSLMHNSISGIPSDVSPMCTRISTLLLASNHCLTMIPDPFFMHMATLEVLDLSYTSIEALPNSISKLGKLSALLLRRCAKLRLIPSLEKLILLRKLDLCHAGIKEIPQGLEMLINLRYLNLHTPYLEFLPCGVLSKLLNLQVLITFGASKTSKVKGDEVACLRKLETFSGQFYNIHEFNIFVYSISTRGREPDMYFIQVGEYHTVTFKEEPESFGKHVKLVKCFIGRGDDELVLPNGIQSLDIHDCHGVASLCDISSLNNATDLRSLEISKCDDVKYAFRASSSTCFRSLESLRLIDLLNFVSLSYKAGAAALPNDMFSNLKSFRIHQCPNIKRLFTPGLLLQLHSLSVIEVTFCPQMKDIIAEDSDESIENHSIDMKKTTNHPMLRHLVLCELPKLKSIYTQTLHCDSLQVIEVFGCPRLNRIPFSPSPVPSNLDKILATKEWWESLEWDQPNAKTAFQPYFKNCIPQKLKFRNRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PL92</accession>
    <name>A0A0D2PL92_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G031900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PL92"/>
    <dbReference type="Gramene" id="KJB07594">
        <property type="protein sequence ID" value="KJB07594"/>
        <property type="gene ID" value="B456_001G031900"/>
    </dbReference>
    <dbReference type="OMA" id="FKSFANC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="12592" checksum="CF4B237B218DA2A7" modified="2015-04-29" version="1">MTTLTITKSAFSNFFLYISWLKPGFAVVFLLDSNHKCYFCGLSLCIGMKRIPVVLAYLLIIYTFVGFKSFANCNFQSLLSTRYTRFKSLKHDLYGRAYEIYSFFKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLR4</accession>
    <name>A0A0D2PLR4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_001G046500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MAP65/ASE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLR4"/>
    <dbReference type="STRING" id="29730.A0A0D2PLR4"/>
    <dbReference type="Gramene" id="KJB07799">
        <property type="protein sequence ID" value="KJB07799"/>
        <property type="gene ID" value="B456_001G046500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4302">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1520:FF:000002">
        <property type="entry name" value="65-kDa microtubule-associated protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF7">
        <property type="entry name" value="65-KDA MICROTUBULE-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="14">
        <location>
            <begin position="814"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="494"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB07799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112889" checksum="8D9504BDBA39D96B" modified="2015-04-29" version="1">MSTTPSDPLLQVETTCGTLLYELQIIWDEVGETDTDRDEMLLELERECLEVYRRKVDQANRCRAQLRQTIADSEAELAAICSAMGERPVHIRQSDQNAGSLKEELSKILPQLEEMKKRKIERRNQFVQVLQQIQIITNEIYGSAKLVSSKAVVDESDLSLRKLEELHKQLNELEKEKNDRLKQVEDHLSMLNSLCLVMGMDFKLTVAEVHPSLGDSEGFWSISNNTIEQLATLIKKLQEVKIQRMQRLQDLGTTMLELWNLMDTPIEEQQMFQNVTCNIAASEHEITEPNTLSVDFIKYVEAEVSRLEELKSSKMKELVLKKRLELEEICRKTHLVPDSQSAVEDAIEAIESGAVGAATILEQIELQIAKVKEEAFSRREILERVEKWLMACDEECWLEEYNRDENRYNAGKGAHLTLKRAEKARSLVNKLPGMVEALASKTMAWEKETEVEFLYDGIRLLSMLEEYTILQQEKEQERRRLRDQKKLQGQLIAEQEALYGSKPSPSKPLSVKKGPRHSTGGASSRRVSLGGAMLPTHKPDSLHSAKATPQTLHKRTERMFQNDHLNHRHDDAIPAFSAFRRGVDIADIPVRKHSFNLVNTNELESPLVRKPFSPISSMVSSKTNTTNTLEDDGETLQKMKPVNFPYTTPSKTTFLVDEENRTPKAMCIAAMTPASTVSVPMQTAMTPAPLIIPFGKPVQEISEEIEQSFEEKRLAFVLAETLQVTTSLVQEKEGGRVGVIVKGDEAAPRRENPMCLGGSSEMMKKKRGRPRKYGADGCLAMALSVTPISSSIPLSREFWPWKQGEMVQKSQHKYEIESSPPARGDKIAYFDVTMKVMSFSQQGGRAICILSANGTISNVTLRQPTSSGGTLTYEGWFEILSLSDSFMPTQNGGTKSRSGGMSISLAGPNGHVLGGGLAGLLVAAGPVQLVVGSFLPGHQQEQKYKQQRTKAAVVSYTREFKVSYGGVMPILTSASFPIQGFRDSAIDSSKTSSAGEESKGHSLSQCEVSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PMK5</accession>
    <name>A0A0D2PMK5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_001G064800</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in transport of phospholipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PMK5"/>
    <dbReference type="STRING" id="29730.A0A0D2PMK5"/>
    <dbReference type="Gramene" id="KJB08099">
        <property type="protein sequence ID" value="KJB08099"/>
        <property type="gene ID" value="B456_001G064800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08100">
        <property type="protein sequence ID" value="KJB08100"/>
        <property type="gene ID" value="B456_001G064800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786824"/>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIVAWAF"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901703">
        <property type="term" value="P:protein localization involved in auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000042">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF70">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1004"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1072"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1111"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="18">
        <location>
            <begin position="890"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
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        </ligand>
    </feature>
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        <location>
            <position position="545"/>
        </location>
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            <name>ATP</name>
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        </ligand>
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        <location>
            <position position="591"/>
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        </ligand>
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        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
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        <location>
            <position position="648"/>
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        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="729"/>
        </location>
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        </ligand>
    </feature>
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        <location>
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        </ligand>
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        </ligand>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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    </evidence>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
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    <sequence length="1195" mass="135014" checksum="32BA3FCD3E1A548E" modified="2015-04-29" version="1">MTGGRRRKQHFSRIHAFSCGKASFRGDHSLIGGPGFSRVVYCNDPECFEASLRNYAGNYVRSTKYTLATFFPKSLFEQFRRVANFYFLICAILSFTPLSPYSAVSNVLPLVVVIGATMGKEAVEDWRRKKQDTEVNNRKVKMHQSDGIFEPTKWIDLKVGDIVKVEKDEFFPADLILLSSSYEEAICYVETMNLDGETNLKLKGASDVTSSLHDDASFQDFKATIRCEDPNANLYSFVGSLELGDEQYPLSPQQLLLRDSKLRNTDYIFGVVIFTGRDTKVIQNSTDPPSKRSKIEKRMDNIVYFLFAVLVGLSIIGSIFFGIETREDLENGKMRRWYLRPDDTTIYYNPKRAAVAAILQFLTALMLYSYLIPISLYVSIEIVKVLQSIFINQDLHMYHEETDKPAHARTSNLNEELGQVDTILSDKTGTLTCNSMEFIKCSIAGTSYGHGITEVERALVWRKGSPLAREVPEINGQVEEFKKEKPLVKGFNFVDERIMNSNWLNEPHADVIQKFLRLLAICHTAIPEVDEETGRISYEAESPDEAAFVVAARELGFEFYERTQTSISLYEFDLSGKKVKRSYKLLNILEFSSSRKRMSVILQNEEGKLLLLCKGADSVMFERLAKNGIEFAEQTKEHIEEYADAGLRTLVLAYREINEEEYVEFNEKFMEAKNIVSADREEMIEEVAESIERDLILLGATAVEDKLQNGVPECIDKLAQAGIKIWVLTGDKMETAINIGFACSLLRQGMKQIIINSGTPENKALEKSGDKTAAAAAYKASVLQQIAEGRQLLTSSNENSEALALIVDGKSLTYALEDDVKDAFLELAIGCASVICCRSSPKQKALVTRLVKTKTGSTTLAIGDGANDVGMLQEADIGVGISGVEGMQAVMSSDIAIAQFRFLERLLLVHGHWCYRRISSMICYFFYKNIVFGFTLFFYEIYASFTGQAVYNDWFLSFYNVFFTSLPVVALGVFDQDVSSRLCLKFPLLYQEGIQNVLFSWLRIVAWAFNGVLSATVIFFFCIRATQHQAFRKGGEVVGLEILGTTMYTCVVWVVNCQMTLSISYFTYIQHLFIWGSIILWYIFLMAYGAMAPSISTTAYKVFIESCAPAGMYWLLTLLVLISSLLPYFIYSAIQVRFFPSYHQMIQWIRSDGQSDDPEYCHMVRQRSLRPTTVGYTARLEAKSRSSRKGGEDHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSG2</accession>
    <name>A0A0D2PSG2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G004400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Possesses activity on acetaldehyde and glycolaldehyde in vitro.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSG2"/>
    <dbReference type="STRING" id="29730.A0A0D2PSG2"/>
    <dbReference type="Gramene" id="KJB06941">
        <property type="protein sequence ID" value="KJB06941"/>
        <property type="gene ID" value="B456_001G004400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780141"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPLYQIT"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000001">
        <property type="entry name" value="Mitochondrial aldehyde dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB06941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="515" mass="56055" checksum="7470A93DB9721B24" modified="2015-04-29" version="1">MRKINTERNLKMADHCNGSSQSSESFVNIPPIKFTKLFIDGNFVDSVSGKTFEAIDPRSGEAITRVSEGDKEDVDLAVKAARFAFDNGPWPRLSGSERGRILMKFADLIEQNIEELATLEAINAGKLFSLCKFMEVPGAAMTLRYYAGAADKIYGTVLKLSKGLQGYTLREPIGVVGAILPWNFPTTMFFIKAAPALAAGCTMVVKPAEQTPLSALYYAHLAKLAGIPDGVLNVVNGFGETAGAAISSHMDIDKVSFTGSTEVGRKIMMAAAASNLKPVSLELGGKSPLLIFDDANVDEAAKFAFDGIFTSKGEICVASSRIYVQEGIYDKIVNKLIEKANAWVVGDPFDPQVNQGPQTDKNQFEKILSYIEHGKREGATLLTGGNRIGQKGYYIQPTIFADVKEDMIIAKEEIFGPVMSLMKFKTMEEAIKRANDTTYGLAAGVITKDLNVANTVSRSIRAGVVWMNCYLLLDVGCPYGGYKMSGFGRENGMDSFNEYLQTKSVVTPIHDSPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTC4</accession>
    <name>A0A0D2PTC4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G166600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTC4"/>
    <dbReference type="STRING" id="29730.A0A0D2PTC4"/>
    <dbReference type="Gramene" id="KJB07321">
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        <property type="gene ID" value="B456_001G166600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SB2A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB07321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="293" mass="32807" checksum="90741282600CA8D2" modified="2015-04-29" version="1">MRPAQPTITTKKALPFSFATRRTPSPFPTTNKIERSPKALGRSAGRTEEVCPARGGSVESFCCLGRELYDLFPYPILWQLQLATTRARPARPERAQRSASIRITLGGLSLLPDLERYYESSVPDSIAAAIWFTGTTKKSHAYVTVIDGFIIFDYEGPGRASGFHSHHHIDDKSPLQRTVAPPTRKGINIETSLPFESENLWRKSGFKFPETTRLYSQREYAAPKIIPSAANVATKLFLWKAPTKMRNSPIKLLVPGELILAKVKEKKMVERFGMVLTKPPAQRFSSFTNRAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZA3</accession>
    <name>A0A0D2PZA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G021200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
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        <property type="entry name" value="CRAL-TRIO_dom"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277:SF3">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46277">
        <property type="entry name" value="OS03G0850700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
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        <location>
            <begin position="135"/>
            <end position="297"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="301" mass="35306" checksum="01CF1CC65EB5E731" modified="2015-04-29" version="1">MDKEKKLKQTQEEEEEMEFKDCENHSQQAQQQEEEKEKIEIGDEIIRSKIGIMRALAERDDPSVKVLIWFIFQLFLTLGFHFYLNFFFIFFKEVDDFMIRRFLRARDLDIEKANTMLLKYLSWRRTFLPKGFVSESEISNQLADNKLCMQGVDKQGRPIVVAFGGRHKPTKGNLEEVKRFVVYGLEKICARMPRGQEKFVAIGDLEGWGYSNSDIRAYIASLSILQDCYPERLAKLFIVHVPYIFMTAWKVVYPFIDSRTKKKIIFVENKKLKSTLLNDIDESQLPDIYGGKLPLVPIENC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8A5</accession>
    <name>A0A0D2Q8A5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G118800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2Q8A5"/>
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        <property type="gene ID" value="B456_006G118800"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to oxidative stress"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
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    </dbReference>
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        <property type="entry name" value="NDUFA12"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB35538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="159" mass="18437" checksum="8CC64D479A967343" modified="2015-04-29" version="1">MATTVVKSALQAIRERGLRSFLRELKDDGFTKCFFDGNLLQTKIHNIGATVVGVDKFGNKYYEKLGDTQAGRHRWVEYAKKDRYDASQVPPEWHGWLHFITDHTGDELLMLKPKRYGVEHKENLSGKGNEFIYHSKGHALNPGQRDWTRYQSWQPTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBW6</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G122700</name>
        <name evidence="3" type="ORF">Gorai_022763</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QBW6"/>
    <dbReference type="Gramene" id="KJB14396">
        <property type="protein sequence ID" value="KJB14396"/>
        <property type="gene ID" value="B456_002G122700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784298"/>
    <dbReference type="eggNOG" id="ENOG502S11S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSTTPCE"/>
    <dbReference type="OrthoDB" id="1939477at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33670">
        <property type="entry name" value="SPLICING FACTOR, PROLINE- AND GLUTAMINE-RICH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33670:SF14">
        <property type="entry name" value="T20H2.15 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB14396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0580549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="251" mass="27289" checksum="5B95D2448C94413D" modified="2015-04-29" version="1">MDDFSMSSYNQLNNIPKRNIGVNFVSKRSEYLASTCTIHGGGFLFAPPSSLTFSHPPSPSILNPILLYQNHHQLPPRLQPPLLPLPTPTKPLHVSLPCRTRSLSSSSCKNKNNKIRDQFLTPKSSKSKQLIISAGKVEDRPKKDNHLKPKQATETQTISKSSFDMAMAPANPLGSDPNDLPIALPSSYRAAGDDAKKDLDEFSGSILPLSPPPSSLPLPKFSLKSKLSCNPEAAGIDCGATDNLRRLLCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QE86</accession>
    <name>A0A0D2QE86_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G167600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QE86"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB15266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26390" checksum="DBDB72DA1164A04B" modified="2015-04-29" version="1" fragment="single">LCDFSNQAFALEKEYSNAKLMRQVLKSLIKRFSIKVTTIEEAKDLERLVIDELIGSLQTFEMILDGAKRNRGKRGKNITLQKNKDLKDENVVLVKQVATKETLLAKELNSMEKIKELVEIKLMLENLSSSSNKLNEIFAAGRRDQGRGCLSFVNKGKSIEESTIRVVRYEVVRWISKYQKMTHVQNKTPLELMHIDLFGPMQIESLVGKRYAFVCVDEYSRYTWSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIW8</accession>
    <name>A0A0D2QIW8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Purple acid phosphatase</fullName>
            <ecNumber evidence="10">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G002800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="11">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="10"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QIW8"/>
    <dbReference type="STRING" id="29730.A0A0D2QIW8"/>
    <dbReference type="Gramene" id="KJB39218">
        <property type="protein sequence ID" value="KJB39218"/>
        <property type="gene ID" value="B456_007G002800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801696"/>
    <dbReference type="eggNOG" id="KOG2679">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWSIGNH"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000027">
        <property type="entry name" value="Purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000898">
        <property type="entry name" value="Acid_Ptase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250360" description="Purple acid phosphatase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB39218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="328" mass="37285" checksum="8A54E2C198C63365" modified="2015-04-29" version="1">MGCDRWVMLVIPIIYALSNVSGELKRFEQPSKGDGSLSFLVIGDWGRRGAFNQSQVASQMGKMGEKLDIDFVVSTGDNFYDNGLRSVHDLAFEESFTNIYTANSLQKQWYSVLGNHDYRGDAEAQLSPLLTKIDTRWLCLRSFIVNAELAEIIFVDTTPFVKSYFQDPEDHIYDWRGINPRKHYIANLLKDVECALRESNAKWKIVVGHHAIKSVGHHGDTRELATHLLPILKANNVDFYMNGHDHCLEHISDTENPIQFLTSGAGSKAWRGDVKQLNREGLKFFYDGQGFMSVQLTQSNAEIAFYDVDGKILHRWNAFKQFGDHSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKS6</accession>
    <name>A0A0D2QKS6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Monocopper oxidase-like protein SKS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_001G048300</name>
        <name evidence="17" type="ORF">Gorai_020555</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QKS6"/>
    <dbReference type="STRING" id="29730.A0A0D2QKS6"/>
    <dbReference type="Gramene" id="KJB07860">
        <property type="protein sequence ID" value="KJB07860"/>
        <property type="gene ID" value="B456_001G048300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785142"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFSMLMA"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13846">
        <property type="entry name" value="CuRO_1_AAO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000012">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000016">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000023">
        <property type="entry name" value="Monocopper oxidase-like protein SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034273">
        <property type="entry name" value="CuRO_1_AAO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF270">
        <property type="entry name" value="MONOCOPPER OXIDASE-LIKE PROTEIN SKS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036292347" description="Monocopper oxidase-like protein SKS1" evidence="12">
        <location>
            <begin position="19"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="30"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="155"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="393"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB07860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0578263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="65720" checksum="004C0F727E62926B" modified="2015-04-29" version="1">MALLLLIHIALFSTLCFAADPSVFLDFKLSYITLSPLGVPQRVIAVNGAFPGPVVNVTTNYNVNINVHNQLDENLLMTWPGIQMRRNSWQDGVLGTNCPIHPKKNFTYQFQVKDQIGSFFYFPSLNFQRASGGFGPIIINNRNIIAIPFAHPDADIVLLVGDWYTKNHTALRTTLESGEELGMPDGVLINGKGPYRYNSTLVPDGIEYEIINVDPGKTYRFRVHNVGTSTSLNFRIEGHNLLLVETEGFYTTQQNFTSFDIHVGQSYSFLVTMDQNATKDYYIVASARFVNETVWERVTGVAILHYSNSKGPASGPLPVAPSDIYNQWSAMNQPRAIRQNTTASGARPNPQGSFHYGSINVTDTYVIQSLPPVRIDGKFRATLNGISFVNPDTPIRLADLHKVKGAYKLDFPNKPHDRTPHMDRSVINATYKGFIEIILQNNDTKMQSFHMDGYAFFVVGMDFGVWSENSRNNYNKWDAISRSTTEVYPGGWTAVLVSLDNVGVWNLRVENLDRWYLGQETYMRIINPEENGKTEMVPPDNVIYCGALQSLQKESQSSSAMALHCGNFKLFLTLAITILALYFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMJ2</accession>
    <name>A0A0D2QMJ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G176800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="B456_003G176800"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ALPHA-LATROTOXIN-LHE1A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HOMEOBOX PROTEIN WARIAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
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            <begin position="189"/>
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        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="3">
        <location>
            <begin position="284"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB20994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="432" mass="47864" checksum="5BEEE57B6BB747BE" modified="2015-04-29" version="1">MMSTNLIINAATNGDIDALYELIAEDPHALDYSDSQPCVLTPLHIAVAEGNTNFALEIMKLYPSLSKKLDPSGWCPFHVALLNNQIATVFRLLETEPDLVRLKGREGLTSLHLAVGSLDGIKHNLLREFLAVSPLSITDTTNRGQTALHIAVNNGNTEALKVLLSFLRRSMYRNALYWEHKVLNWKDENGETVLHVAVKKNDIEAVKLLLNCNIKVNARNLHSYTAVDIAIENNNSEVLNVLNKVGAKDGILIEEMKQLTLEAKPTLLDNVIRFVKGQKIDISSETRDALLVVAALVATATFQAVLSPPGGLRQADSSDNDSLPFSKVGKVVMKEWLFIIFLILNGTSFWVTIITIYLLLPTGFYGQLLTLPLILFSITYLFCSTIISPSLVCAIVNFSFFIFCVALLSLGVVLVSNRSLLSYIKKLWPRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMP3</accession>
    <name>A0A0D2QMP3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Man1/Src1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G180000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_003G180000"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:nuclear periphery"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heh2/Src1"/>
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        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="68"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="410" mass="46739" checksum="D5D617A2296F342F" modified="2015-04-29" version="1">MPSTPKERPKSKRNSYSKNSSLNSILEPPQSLFPSKGEFLRLITVLAIASAVALSCNYFLTFFTSTSKPFCDSNLDPIDSFSDSCEPCPSNGECYEGNLECIYGYRRHGKLCIEDRDIDETAKKLSESVEAGLCEAYAQVLCYGTGTVWVRENDIWNDLDRHNLMQNVGSDHTTYVYMKRRAMETIAKLLETRTNLHGLQEFKCPDALAEHYKPLTCRFRELVSKHSLIIMSICAGLIGCAVLFLKVRQRMYISARAEELYNQVCEMLEENALRSKNVDGEGESWVVASWLRDHLLLPRERKDPQLWKKVEELVQDDSRVDRYPKLVKGESKVVWEWQVEGSLSSSGRRKKGEGIELKSNESINTNINQSSRTLKTGALLAHIVHYASCSLFNLVSYLSNVVRVPWRPFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQX7</accession>
    <name>A0A0D2QQX7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G028700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQX7"/>
    <dbReference type="SMR" id="A0A0D2QQX7"/>
    <dbReference type="STRING" id="29730.A0A0D2QQX7"/>
    <dbReference type="Gramene" id="KJB22089">
        <property type="protein sequence ID" value="KJB22089"/>
        <property type="gene ID" value="B456_004G028700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790208"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CILMFRV"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF2">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN PBP1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="63"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB22089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11197" checksum="AB72725F0D62AA3D" modified="2015-04-29" version="1">MEEVIDIVVDFEDYFPSMMEKYGAEWLLGEVCNGFRLLMDAEKGVITFESLKIKSAMLGLGDMEDDEIVCMLSEGDLDGDGALNQLEFCILMFRLSPGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSL0</accession>
    <name>A0A0D2QSL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G128300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 13">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSL0"/>
    <dbReference type="STRING" id="29730.A0A0D2QSL0"/>
    <dbReference type="Gramene" id="KJB19980">
        <property type="protein sequence ID" value="KJB19980"/>
        <property type="gene ID" value="B456_003G128300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB19981">
        <property type="protein sequence ID" value="KJB19981"/>
        <property type="gene ID" value="B456_003G128300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788778"/>
    <dbReference type="eggNOG" id="KOG0374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NITGMMY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000212">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF499">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="124"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB19981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="309" mass="34938" checksum="2FCE0D2C20F8E193" modified="2015-04-29" version="1">MGSVTMDPAVLDNIICRLLEFKQGRTGGKQVQLMEGEIHQLCTVAREILIQQPTLLELEAPIKICGDIHGQYVDLLRIFEYGGFPPSVNYLFLGDYVDRGKQSLETICLLLAYKIKYPDNLFLLRGNHECASINRIYGFYDECKRRFNVKVWRIFTECFNCLPVAALIDDKILCMHGGLSPDLTNLDQIRALTRPTDVPDTGLLCDLLWSDPGRDIKGWGMSDRGVSFTFGPDRVSDFLMKNDLDLICRAHQVVEDGYEFFADRQLVTIFSAPNYCGEFDNAGAMMSVDESLMCSFQILKPADKRPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QU26</accession>
    <name>A0A0D2QU26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Terpene synthase metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G362700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QU26"/>
    <dbReference type="STRING" id="29730.A0A0D2QU26"/>
    <dbReference type="Gramene" id="KJB61507">
        <property type="protein sequence ID" value="KJB61507"/>
        <property type="gene ID" value="B456_009G362700"/>
    </dbReference>
    <dbReference type="OMA" id="SIRCYIE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9738" checksum="84B2D35E5431AAA1" modified="2015-04-29" version="1">MYESGVSEEEAHEHIRKLIDATWKKINEDQMAKLPFSRKFIEISKNIARVSLLMYQNGDGHGIEDKETKDRVLSLFVHPISLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVG7</accession>
    <name>A0A0D2QVG7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MLO-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MLO</name>
        <name evidence="10" type="ORF">B456_004G106900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in modulation of pathogen defense and leaf cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminus contains a calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MLO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVG7"/>
    <dbReference type="STRING" id="29730.A0A0D2QVG7"/>
    <dbReference type="Gramene" id="KJB23604">
        <property type="protein sequence ID" value="KJB23604"/>
        <property type="gene ID" value="B456_004G106900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791019"/>
    <dbReference type="OMA" id="ITHTPTW"/>
    <dbReference type="OrthoDB" id="1388414at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004326">
        <property type="entry name" value="Mlo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942:SF69">
        <property type="entry name" value="MLO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31942">
        <property type="entry name" value="MLO-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03094">
        <property type="entry name" value="Mlo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 8" id="KW-0568">Pathogenesis-related protein</keyword>
    <keyword evidence="4 8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU280816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB23604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="50334" checksum="FBAF7DF35000421D" modified="2015-04-29" version="1">METVEPISLYYKPTWVVAAVCFVIILISLFAERGLNYLGKCLTHSHQDALFEALQKLKAELMLLGFISLLLNVFQGLISQICIPSHFESTMLPCKKHTEIKGHENYSPPAINNERHLLSEKSGSFSDHCSLQGKVPLLSTESFHELHILIFVVAVVHVVSCAVILVLGGARIRQWKPWEDSIKVAAGPAKVTHRHHLNNVLKKLAWGYWRRAAVISWIISFFKQFYSSVTMSEYIALREGFIMTNCLSHQEFDFHKDMVESLERDFRHVVGISWYQWLFVVVFLAMNVEGWHTYFWLSFLPIVLLLLVGAKLEHIIVRLAQDVDVMKKHPGQEPAWVRPSDEYFWFNRPRLLLDFIHFILFQNAFEIAFFFWILWTYGFHSCMMEKKGYIITRLIIGVIVQVLCSYITLPLYALVTKMGTASMAELVSVPVQSPGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QWR2</accession>
    <name>A0A0D2QWR2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">phenylalanine ammonia-lyase</fullName>
            <ecNumber evidence="6">4.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G416400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-phenylalanine = (E)-cinnamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21384"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="EC" id="4.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phenylpropanoid metabolism; trans-cinnamate biosynthesis; trans-cinnamate from L-phenylalanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.24" evidence="6"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QWR2"/>
    <dbReference type="STRING" id="29730.A0A0D2QWR2"/>
    <dbReference type="Gramene" id="KJB62427">
        <property type="protein sequence ID" value="KJB62427"/>
        <property type="gene ID" value="B456_009G416400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00713">
        <property type="reaction ID" value="UER00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045548">
        <property type="term" value="F:phenylalanine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009800">
        <property type="term" value="P:cinnamic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.20:FF:000001">
        <property type="entry name" value="Phenylalanine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="8" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB62427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="559" mass="61217" checksum="FB5254DF6D040790" modified="2015-04-29" version="1">MERIPQGKPLSSLSSVDPLSWGVAADSLKGGHLDEVKHMVSEYRRPLVKFGGETLTIAQVAAVAKSELGVKVELSEGARAGVNASSDWVLEGLHNGVDSYGITTGFGANSRLRTKDGAALQKLLIRYSGIRFEILEAITKLLNHNVTPCLPLPGSVTAFGDIIPLSYIVGLLIGGPNSKAIGPNGEPLDAQEAFRVADIDSKFFELQPKERLALVNGTAVGSTMAAMVLFEANILVVLLPEFIDHLIHKLKHHLGQIEAAAIMGHIPEGSTIFTMAKRIHEIDPLQKPKQDNYALRSAPQWLGPQIEVIRFLQYLANPVTTHVQSIEQHNQDVNSLGLISALKTAEVIDLLKLMLTTFLVALCQAIDLRHLDDNLKDIVKNIVGQIAKKTLTTGTNGKLRPLRFYEKDLLQAVDRVYIFTYIDDPSSATYPLMQNLRQVLVEHAMIEGEMEKNPSTSIFQNIASFEDELKVVLPKKVENVRARVENGNAAISNKIKDCRSYPLYKFVTGPLGTGLLTGQKVTSPGEEFDKVFNAMCQGKIIDPIMESLKELNSAPIPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4Y4</accession>
    <name>A0A0D2R4Y4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G125300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4Y4"/>
    <dbReference type="STRING" id="29730.A0A0D2R4Y4"/>
    <dbReference type="Gramene" id="KJB14445">
        <property type="protein sequence ID" value="KJB14445"/>
        <property type="gene ID" value="B456_002G125300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784741"/>
    <dbReference type="eggNOG" id="KOG2293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262769at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071339">
        <property type="term" value="C:MLL1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044545">
        <property type="term" value="C:NSL complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002151">
        <property type="term" value="F:G-quadruplex RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22687">
        <property type="entry name" value="FHA_MCRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000052">
        <property type="entry name" value="Microspherule protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037912">
        <property type="entry name" value="MCRS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025999">
        <property type="entry name" value="MCRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13233:SF0">
        <property type="entry name" value="MICROSPHERULE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13325">
        <property type="entry name" value="MCRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="776"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="877" mass="95945" checksum="F4E30C0A893D836F" modified="2015-04-29" version="1">MGALAPVLSTWIPEDDLLLKNAIEAGASLESLAKGAVQFSRKFTVRELQDRWHSLLYDPVVSEEASSRIIEFERSASSLSLKFGRTGNSKDNKSLGGKRKSESVRSCYYALRKRICNEPFNTMDLSFLIAPNDGNYVGLEDEPLPGNCMLGNPISDQFGVQETNMNIMSCSFPQMLADDGAGVGDECTTDGFQTTNHNPDDSSFPVEPVNLHKEIPHMLRENQFLLESGSGIEELHGSKELPVSSLFSANDLMVKPSSTFDQINNDPENICSEFEGNQVFNSPVMDCGLSIWGTDEGLSASAIPTDGHEEKDMQGDVYALPGDIDTKSDHAAEHDVTTDSKLEPDMPCAEMGHQTADTEGYLVEITNTLMNDEPFFMDVDAKDVIGKSYFDGLSSFLASSPNNCDQDQMPDVTEAMASEAQDNLANASSCLGELDEVAGSSAADGPVSCDSEALMLSSVLTSNCQFPELTNGIICCTLNTEDPEIPCNEDVFSKQLCPSVVSSTQHVFKEAGNPLSASFKDFSGGQKTDGGPFLVQRDQRDPGQSIGVSQTKESQMVPEMGQLHPVNNCRVKCKDSSCVAPKTDGFLANVSPQTNSKNITEGTLQPTLLKERSESIISGKHLGHTSADSLREKPGLCSDNHNSLYSFAIKQEVDALEKIKDHQATSAEVGPMDIISPEPVIDHPPPDLEELMIESDDDVPYFSDIEAMILDMDLDPDDQDLWDQEVARYQHEDYKKAIIRLEQVSHSYMQRAIASHGAFAILYGRHSKHYIKKPEILLGRTTEDFVVDIDLGREGCANKVSRRQAIFNLEDDGSFHLKNLGKCSVSINNKEIGPGQSLSLDSGCLIEIRGMPFIFETNQTCVKQYLNSKLRKSGGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R890</accession>
    <name>A0A0D2R890_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G026600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R890"/>
    <dbReference type="STRING" id="29730.A0A0D2R890"/>
    <dbReference type="Gramene" id="KJB28084">
        <property type="protein sequence ID" value="KJB28084"/>
        <property type="gene ID" value="B456_005G026600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYLFLAN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF2">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="5"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="13">
        <location>
            <begin position="306"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB28084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="981" mass="111017" checksum="F1CE643798A170FA" modified="2015-04-29" version="1">MQCLDDQRSPLLQLQHHLYYAPNFTFSSNFDLWDVNTHCCSWEGVTCDAYGHVVGIDLSYKNLSGSFHPIFNLHRLQRLNLAGNNFNTTLFSYGFDKLQNLTHLNLSSSCFHGQIPLEISYLTRLVSLDLSNQDSCYLRYYTILDPYSGVYYYYDPLPYELQQPLKLENPNFKTLIKNLRFLTELYLDSVDISTQSAKWCETTSLVLSNLRVLSLSNCGLKGPLCPSLSRLSFLSKLILDGNPISYLPPNFLEISSRLVSLSLSGCNLNGQFPTGILLLPQIQSIHISSNDQLKGQLPEFPANNALQSLLLSYTNFSGKLPQSIGNLKFLTDLDLYYCNFFGPIPSSIANLSHLVNLDLSNNYLTGPIPKSILQLPRLEGLYIGENSFSSMKLDMFVQLKNLKGLHLSNVSLLSESDNKSLTFPQLESLSLRSCNLTEFPEFIKRQDKLKYLDLSNNKISGAIPNWVWKKSLWYLFLANNHLSSLDQLLPNQSSPSSQTSLTRPICNLSQLRNFNASHNNLSGPIPNCLGKMNDLNLLDLQGNSFSGMLPKFSKATQLYILKVSENRLEGKLPRSLVECTLLEVLDVGNNMMNDTFPFWLQKLPYLMVLILRENRFYGQIKHFKHKFVFPNLDVLDIASNQFSGELSINFLQTTRLRSLKIGGNKLEGKLSRSLANCKALEVLDLGNNMVHDTFPFWLEKLPSLKVLILRANRFYGTIAEFNTERGFPKLRILDIGSNNFSGNLSIEFLLSLKAMMQLRNDDKAKLDYIGEDYYQDSVTIFNKGIEMFYQKVLTILTCLDLSNNSFHGRIPEEIQMLRSLKVLNLSYNSFSGEIPVALGNLKDLESLDLSQNELSGKIPPQLTSLTFLAALNLSYNQLEGSIPQSNQFITFSNDSYHGNPKLCGLPLSRKCNEVGLPMPPPPRGDEESWLYAMTTWKIALMGYANGLVVGLCIGYTGLNELGNKWVDRLKKHGERNKRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9B6</accession>
    <name>A0A0D2R9B6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pectate lyase</fullName>
            <ecNumber evidence="4 9">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G231500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9B6"/>
    <dbReference type="STRING" id="29730.A0A0D2R9B6"/>
    <dbReference type="Gramene" id="KJB26226">
        <property type="protein sequence ID" value="KJB26226"/>
        <property type="gene ID" value="B456_004G231500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793449"/>
    <dbReference type="eggNOG" id="ENOG502QT22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCLTWAL"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF74">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112769" description="Pectate lyase" evidence="9">
        <location>
            <begin position="28"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="106"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB26226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="378" mass="42176" checksum="0D8D52201D98B650" modified="2015-04-29" version="1">MATILSRCLTWALFMVFLMASFSSSLANMNVIDKCWRGNPFWQSHRQQLAKCSVGFVGKMINNIGKDVVKYKVTDPSDNPLSPKPGTLRYGTTMIKGKVWITFKNSMTITLQRPLLLSSFTAIDGRGIDVHITGVGCLLVYQVTDIIIHGLRIHHCKAQPPSTVMGPNAKVIPLGQMDGDAIRLVTARKVWIDHNTLYECQDGLLDVTRGSTNITISNNWFRNQDKVMLLGHDDGHLRDRNMKVTVIFNHFGPNCNQRMPRVRHGYAHVANNFYQGWEQYAIGGSMSPSIKSEANFFVASNDVGNKEVTWRKGEKGLWKFYSVGDVFKNGASFSKQTGVGGAKPNYNREQDFKVVDAGSVKELTSESGVLRCSRSLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAF8</accession>
    <name>A0A0D2RAF8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G070500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YTHDF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAF8"/>
    <dbReference type="SMR" id="A0A0D2RAF8"/>
    <dbReference type="STRING" id="29730.A0A0D2RAF8"/>
    <dbReference type="Gramene" id="KJB28809">
        <property type="protein sequence ID" value="KJB28809"/>
        <property type="gene ID" value="B456_005G070500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796946"/>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DHMERTS"/>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF92">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="6">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="654" mass="71958" checksum="65A29DB0FE585124" modified="2015-04-29" version="1">MYQEGAPEIVIDQGMYYPTATNYGYYCTGFESPVEWEDHQNIFSADGPDVQFAGAQTEPLPYVYYTPSYGYAQSPYNPYNPYIPGAVVGDGSFVGAQQYYPFPPYQNPVSPTAYVPVLIQPDGIPSSSTDSFLDTHASIGTRPDGRGVRYNLASASAAASRKSAPNQADSLSRVTDGQSKHYAIQESISASSGSASARAHQVRVASGSVQPIGNIPGGKLPSYRNQLKTDLPVGNAISDYGASSPGRGVLDRLRPKIHVSRVFNDAHGSLDSWAEQNRGPRTNRSKNQLMVKAYTSKAGNSDAEGNIIIYTDQYNKDDFPIDYVDAKFFVIKSYSEDDVHKSIKYNVWSSTPHGNKKLDSAFEDAEKIAAGKPSGCPIFLFFSVNASGQFCGVAEMIGPVDFQKDMDFWQQDKWSGSFPVKWHIIKDVPNSHFRHIILGNNENKPVTNSRDTQEIMYKQGMEMLKVFKNHAMKTSLLDDFMYYENRQRIMQEEKAMQLIKSIENPVLAPAFDPVNKLNRVELLLNEHERSSKQSDPELLRTIVPSSNQPVSTDCDRTNARRMNESSGKIAVEAKDDASTLKISSLSINPKQDESKISTDAATKSDAVEVVNIGSVTVKVNKFTDSPGFLTVGTIPLNPKTPQLDEGGVSAKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RD25</accession>
    <name>A0A0D2RD25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G116900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RD25"/>
    <dbReference type="STRING" id="29730.A0A0D2RD25"/>
    <dbReference type="Gramene" id="KJB29749">
        <property type="protein sequence ID" value="KJB29749"/>
        <property type="gene ID" value="B456_005G116900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INGVIMN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009532">
        <property type="term" value="C:plastid stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF12">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 5, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB29749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9673" checksum="BB039AAD4CC9B8F6" modified="2015-04-29" version="1">MIHQPLGGAQGGQTDIDIQANEMLHHKANLNGYLAYHTGQSLDQINQDTDRNFFMSVKEAKEYGLINGVIMNPLKALHPLAPTADSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFE8</accession>
    <name>A0A0D2RFE8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G044000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFE8"/>
    <dbReference type="STRING" id="29730.A0A0D2RFE8"/>
    <dbReference type="Gramene" id="KJB28341">
        <property type="protein sequence ID" value="KJB28341"/>
        <property type="gene ID" value="B456_005G044000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000001">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251012" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="10">
        <location>
            <begin position="27"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB28341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="201" mass="20919" checksum="84EFF18C35A75C1A" modified="2015-04-29" version="1">MALGKITLVQGLALVMVTLLWTGTMAQSDCTSVLITMAPCFDYVTGTSSTPSVPCCSQLANVVQLQPHCLCMALSGGGSSVGVEVNQTLALALPQLCHVKTPPENNCKAADGPAVISISPSGSPQGLPPHSNDTPGSNSSTSEQLQLLPVMLSSTHPFSSSCSCCPLLCFLQLGPPSPKAPIHMLLLLISDPIYLCFILHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFJ7</accession>
    <name>A0A0D2RFJ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">Peroxidase</fullName>
            <ecNumber evidence="4 18">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_003G029000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 18">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFJ7"/>
    <dbReference type="STRING" id="29730.A0A0D2RFJ7"/>
    <dbReference type="Gramene" id="KJB17955">
        <property type="protein sequence ID" value="KJB17955"/>
        <property type="gene ID" value="B456_003G029000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787667"/>
    <dbReference type="eggNOG" id="ENOG502QV9M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIRHDCA"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000008">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF3">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 18" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112715" description="Peroxidase" evidence="18">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="27"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="37"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="70"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="126"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB17955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="36005" checksum="038060880E1E3FC2" modified="2015-04-29" version="1">MAHFITFLLVLSLSLTFSLLPETASAQLRQNYYAKTCPNVESIVRNAVTQKFRQTFVTVPATIRLFFHDCFVQGCDASVIIQSTGSNKAEKDHPDNLSLAGDGFDTVIKAKQAVDAVTSCRNKVSCADILAMATRDVIALSGGPSYAVELGRLDGLSSTAASVNGKLPHPDFNLNQLNSMFAAHGLTQTDMIALSAAHSVGFSHCSKFSNRIYNFSRQSAVDPTLNRAYATQLQQMCPKNVDPRIAINMDPNTPRAFDNVYYKNLQQGKGLFTSDQVLFTDKRSKPVVNAWAANSNTFNSAFITAITKLGRVGVKTGRNGNIRRNCDAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFY5</accession>
    <name>A0A0D2RFY5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G033300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFY5"/>
    <dbReference type="MEROPS" id="S28.A02"/>
    <dbReference type="Gramene" id="KJB18075">
        <property type="protein sequence ID" value="KJB18075"/>
        <property type="gene ID" value="B456_003G033300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787707"/>
    <dbReference type="OMA" id="QTCNQMV"/>
    <dbReference type="OrthoDB" id="2130629at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.980:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF38">
        <property type="entry name" value="LYSOSOMAL PRO-X CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250155" description="AB hydrolase-1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB18075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="57617" checksum="AC163DE621710A8A" modified="2015-04-29" version="1">MASSTVSFIIIIITTVLLPSLSSQLSDLFPSNNPPPFLGKHSHPIKQPNHHQQYRYETRYFSQPLDHFSFLDLPRFRQRYLINTEHWVGPSRSGPIFLYCGNEGDIEWFAVNTGFVWDIAPRFGAMILFPEHRYYGDSMPFGSKEEAYRNATTLSYLTAEQALADFAVLITDLKKNLSAEGCPVVLFGGSYGGMLAAWMRLKYPHVAVGALASSAPILQFEDIVPPETFYNIVSNSFKRESSSCFDTIKNSWNALRSEGQKEDGLKQLSKTFHLCRELTSVQGLSDWLDSAYSYLAMVNYPYPSNFLMPLPGHPIREVCKRIDGSPAGSSILERIFNGVSVYYNYTGEVDCFQLDDDPHGMDGWNWQACTEMVMPMSSDQNTSMFPAYDWDYSAFREGCQRDFQVTPRPRWITTEFGGHDIEHVLKSFGSNIIFSNGLLDPWSGGSVLKNISETIIALITKEGAHHIDLRASLTEDPDWLVEQRATEIKLIQGWIYNYSKKMKATFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGZ8</accession>
    <name>A0A0D2RGZ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G048700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 20S core complex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGZ8"/>
    <dbReference type="STRING" id="29730.A0A0D2RGZ8"/>
    <dbReference type="Gramene" id="KJB69897">
        <property type="protein sequence ID" value="KJB69897"/>
        <property type="gene ID" value="B456_011G048700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000028">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB69897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="248" mass="27198" checksum="D08DB3A19CFC78E3" modified="2015-04-29" version="1">MGDSQYSFSLTTFSPSGKLVQIEHALTAVGSGQTSLGIKAANGVVIATEKKLPSILVDETSVQKIQCLTPNIGVVYSGMGPDFRVLVRKSRKQAEQYHRLYKEPIPVTQLVRETAAVMQEFTQSGGVRPFGVSLLVAGYDDNGPQLYQVDPSGSYFSWKASAMGKNVSNAKTFLEKRYTDDMELDDAVHTAILTLKEGFEGQISGKNIEIGIIGTDRKFRQAPALTLSPFSLKLYGGVMLMRKMTFWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHI9</accession>
    <name>A0A0D2RHI9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G082300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHI9"/>
    <dbReference type="STRING" id="29730.A0A0D2RHI9"/>
    <dbReference type="Gramene" id="KJB29056">
        <property type="protein sequence ID" value="KJB29056"/>
        <property type="gene ID" value="B456_005G082300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797084"/>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAYLYEC"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08301">
        <property type="entry name" value="alcohol_DH_plants"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001292">
        <property type="entry name" value="Alcohol dehydrogenase class-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF26">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="34"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="205"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB29056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="41029" checksum="A3AE7638F651D13B" modified="2015-04-29" version="1">MSTAGQVIRCRAAVAWESGKPLSIEEVEVAPPQKDEVRIKILFTSLCHTDVYFWDAKGQNPLFPRILGHEAGGIVESVGEGVTDLKPGDHVLPIFTGECKECPHCLSEESNMCDLLRINTDRVGMINDGKSRFSVNGKPIYHFLGTSTFSEYTVVHVGQVAKINPHAPLDKVCVLSCGMSTGFGATVNVAKPKKGQSVAIFGLGAVGLAAAEGARVSGASRIIGVDLNPSRFEQAKKFGVTESVNPKDYNKPVQEVVVEMTGGGVDRSVECTGSIQAMISAFECVHDGWGVAVLVGVPNKDDEFKTHPVNLLNEKTLKGTFFGNYKPRSDIPAVVEKYMNKELELDKFITHTVPFSEINKAFELMLAGEGLRCVIRMDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHK9</accession>
    <name>A0A0D2RHK9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GBF-interacting protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G058000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHK9"/>
    <dbReference type="STRING" id="29730.A0A0D2RHK9"/>
    <dbReference type="Gramene" id="KJB70102">
        <property type="protein sequence ID" value="KJB70102"/>
        <property type="gene ID" value="B456_011G058000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR20">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009719">
        <property type="entry name" value="GIP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47070">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47070:SF2">
        <property type="entry name" value="OS06G0206100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06972">
        <property type="entry name" value="GIP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBF-interacting protein 1 N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB70102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="854" mass="91978" checksum="D57C39FCFCAEEB0C" modified="2015-04-29" version="1">MVSGARTEGHISARVSKTIQSIKEIVGNHSDDDIYVALKEANMDPNETAQKLLHQDTFHLVRRKRDRKKESIGYQGSMDPRKFSENAGQVMKFRTYPERGSRRGGYSRNTLPDARVNREFRVVRDNRVNQNANKDTKPPVSPCSTSLNEQVPMNVAEKGSTGTSNQRPFSFQSSSQTASAPSSSHPRHARDANSSGAYRKEISEEKRIFIPNSASRSHAVKPNNIQAHSATQSSSSSVVGVYSSSTDPVHVPSPDSRSSGAVGAIKREVGVVGVRRHPPEDASKDSSGSSTLSNSLVGKDASSEAFQPFPSISRAEREVRDNHTSASESAMSGISGSRSFVSNPYGSRQHQHVLVHQKANLHNKEWKPKSSQKSSVNNPGVIGTPKKSASPPAEDAKGLDPATAKLQEKFSQVNIYENENVVIAQHIRVPENDRHGLTFGSFGVEHDSSRNFAPGFHATGVAEDSNGESAARFLSVAPDTSSDDSAAGKPINIIDDQLRNSGSNSPPSGTASEHQFPDKKDASSPQNLGSYADIGMVQDNGQSYAPSEPQQQQDPPELPSFSQAYDPQTGYDLPYFRPSMDETARGQGLLSPQEALSGHAANIPASTIPMVQQQQPPVAQMYPQVHVPHYANLMPYRQFVSPIYLPQMAMPGYSSNPAFPHPSNGSSYLLMPGGSTHLGANGVKYGIQQFKPVPAGNPTGFGNFTSPSGYAINAPGVVGSATGLEDSSRTKYKDGNIYVQNQQADTSDLWMQNPREVPSLQSAAYYNMPQTPHGYMPSHTGHASFNAAATQSTHMQFSGLYHPPPQPAAMANPHHLNPAMGANVGFGVAPAAPGAQVGAYQQPQLGHLNWTTNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLF5</accession>
    <name>A0A0D2RLF5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-l-methionine decarboxylase leader peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G149200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLF5"/>
    <dbReference type="STRING" id="29730.A0A0D2RLF5"/>
    <dbReference type="Gramene" id="KJB30426">
        <property type="protein sequence ID" value="KJB30426"/>
        <property type="gene ID" value="B456_005G149200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S799">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSWQYES"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012511">
        <property type="entry name" value="AdoMetDC_leader"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35727">
        <property type="entry name" value="BNAA05G33520D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35727:SF5">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE DECARBOXYLASE LEADER PEPTIDE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08132">
        <property type="entry name" value="AdoMetDC_leader"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="51" mass="5544" checksum="FDE0AF0C5B05AFCA" modified="2015-04-29" version="1">MESKGGKKKSSSSKSLFYEAPLGYSIEDVRPNGGIKKFRSAAYSNCARKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLH8</accession>
    <name>A0A0D2RLH8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PB1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G259100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLH8"/>
    <dbReference type="STRING" id="29730.A0A0D2RLH8"/>
    <dbReference type="Gramene" id="KJB32744">
        <property type="protein sequence ID" value="KJB32744"/>
        <property type="gene ID" value="B456_005G259100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795452"/>
    <dbReference type="eggNOG" id="ENOG502QRI2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QHARTNR"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06407">
        <property type="entry name" value="PB1_NLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045012">
        <property type="entry name" value="NLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055081">
        <property type="entry name" value="NLP1-9_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034891">
        <property type="entry name" value="PB1_NLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003035">
        <property type="entry name" value="RWP-RK_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32002:SF46">
        <property type="entry name" value="PROTEIN NLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32002">
        <property type="entry name" value="PROTEIN NLP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22922">
        <property type="entry name" value="GAF_NLP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02042">
        <property type="entry name" value="RWP-RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51519">
        <property type="entry name" value="RWP_RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RWP-RK" evidence="6">
        <location>
            <begin position="483"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="684"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="471"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="782" mass="87283" checksum="002BB362C8875D5B" modified="2015-04-29" version="1">MVFKNMEGDVGFYDDAAMDMDFIDELLFEGFNINSDRGQASLDLCRSENRAVTSMSRLMQAVLYLKESTKGRDGVLIQIWVPVKKGDKHVLTTQGQPYSLNTNCKSLEIFRDVSESYSFPAEEDSEGPIGLPGRVFLGKLPEWTPDVRFFRRDEYRRVGLAQKYNVGGSFALPFFEQGSGTCLGVVEIVSCTQKINYRPELEHVCKALEAVDLRSSHCFTPPNVKGYNELYRVALPEITEVLRSICKRYELPLALTWAPSQHSDKNFYCCVSTSGSFCFVADEGLTGFLEACSEHQLFRGQGIVGRAFTTNKQCFATDITAFSKTNYPLSHHARMFGLRAAVAIPLQSAFTGSVVFVLELFLPKDCHDSEAQKRMINSLSGFMQQACRSLQVIVDKELEEEVILPVKEMFKSNKKETEVRIFSSKEDSPVESSSWIAHMMEAQEKGKGISSSWEYKKELDFRQVHQHARTNRVDSGHQVLDGKKAGEKKRKKTEKTIGLQDLRRHFAGSLKDAAKSIGVCPTTLKRICRQHGITRWPSRKIKKVGHSLRKLQVVIESVQGAEGAIQIGSFYSSFPELSSPNFSNNVPSSTLKLSNHSMSSEPRLETAMFSQEATASKSPLSSSSQSSGSSTCCSSGAKQQSTRINALGGMEDPGGPLKSVIGDAKLHASNQHEMKLLQHQTGGDLRVKAMFGQVKLLFGLQPNWGFIDLQREIAKHFNIEDVDRINLKYLDDDNEWVLLTCDADLEECIDIYKSSQTHTIKISLHQASNLNLGSSFGYSDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLK5</accession>
    <name>A0A0D2RLK5_GOSRA</name>
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        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G146000</name>
        <name evidence="14" type="ORF">Gorai_016758</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLK5"/>
    <dbReference type="STRING" id="29730.A0A0D2RLK5"/>
    <dbReference type="Gramene" id="KJB30481">
        <property type="protein sequence ID" value="KJB30481"/>
        <property type="gene ID" value="B456_005G146000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794247"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDKHIPK"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048608">
        <property type="term" value="P:reproductive structure development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11076">
        <property type="entry name" value="CYP78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000016">
        <property type="entry name" value="Cytochrome P450 78A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051996">
        <property type="entry name" value="Cytochrome_P450_78A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47946:SF10">
        <property type="entry name" value="CYTOCHROME P450 78A5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47946">
        <property type="entry name" value="CYTOCHROME P450 78A7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="8 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB30481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0586003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="518" mass="58663" checksum="6D59096AADF1F141" modified="2015-04-29" version="1">MSLEHGFLLLRSPLLSLEAFLWALLLVGTIALWLSPGGIAWARFRSKTRFSIPGPVGLPLLGLLTVFNGSTPHRILAKLAKTLNAVKLMAFSVGFTRFIISSDPETARDILHNSAFADRPVKESAYELLFHRAMGFAPFGDYWRNLRRISATHLFSPKRIAGFEGYRREIGIKMMDEINGIMKAGDEVQIKKVLHFGSLNNVMATVFGKKYDFEKVGEGYELEELVSEGYELLGIFNWSDHFPLICWLDLQGVRKRCRNLVSRVNVFVGKIIEEHRLKRLSEGLNDDNCNVGEFVDVLLDLEKHEKLADSDMIAVLWEMIFRGTDTVAVLLEWILARMVLHPEVQAKAQAEIESVVGKSKHVSDSDIPNLPYLQAIVKETLRVHPPGPLLSWARLAIHDVHVGDYFVPAGTTAMVNMWAITHDEKLWEEPERFKPERFMEEDISILGCDLRLAPFGSGRRVCPGKAMGLATAHLWLAQLLQRFKWIPTEDRNVDLTEHLKLSLEMKNPLVCRAIPRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNT6</accession>
    <name>A0A0D2RNT6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G164900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNT6"/>
    <dbReference type="Gramene" id="KJB20790">
        <property type="protein sequence ID" value="KJB20790"/>
        <property type="gene ID" value="B456_003G164900"/>
    </dbReference>
    <dbReference type="OMA" id="WHEFEHP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB20790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="261" mass="30239" checksum="AF689AF65CA6F8E9" modified="2015-04-29" version="1">MKNHGDKLMVLASEESGRGKLENRSSTFSHIFVSATPYNVYKDDQSLESPFITFKFNIKMSYVLDKPDKSVPSYISKHDSWHEFEHPVDELTRGFICSLFVDAKIPFALKNLHWKKHDFDKESIPLVSTDCVVSSILDVCSDMINAARESGRKKLFLLVMIKKQVVVPRDEYLAMLKAKEGQEVLCNVEDMIRLQARGWNFQRSDWEDMANVVRRAGLGDSIKKRFGFSSRTCYERIDKTRFKSTRRQVMCPICRFMLPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRP6</accession>
    <name>A0A0D2RRP6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G008000</name>
        <name evidence="8" type="ORF">Gorai_010812</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tetraspanin (TM4SF) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0593884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRP6"/>
    <dbReference type="STRING" id="29730.A0A0D2RRP6"/>
    <dbReference type="Gramene" id="KJB53853">
        <property type="protein sequence ID" value="KJB53853"/>
        <property type="gene ID" value="B456_009G008000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769689"/>
    <dbReference type="eggNOG" id="ENOG502QQQH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICKTLMD"/>
    <dbReference type="OrthoDB" id="1892640at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044991">
        <property type="entry name" value="TET_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018503">
        <property type="entry name" value="Tetraspanin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32191">
        <property type="entry name" value="TETRASPANIN-8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00259">
        <property type="entry name" value="TMFOUR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00421">
        <property type="entry name" value="TM4_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB53853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0593884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30472" checksum="1B9875E08F92B3D3" modified="2015-04-29" version="1">MAFRLSNNLVGILNLITFLLSIPILGAGIWLRREGVTECEQFLDTPVIIIGVFLMLVSLAGLIGACCRVTWLLWLYLVVMFLLIVLGIVFTIFAFVVTNKGAGQVLSGKGYKEYRLGDYSNWLQKRVTDNKNWNKIKSCLADSKVCTDFHDKYLNASLPEFYQAHLSAVQSGCCKPSNDCQFNYVGPTNWTRGSGVSNNPDCNLWDNDPKTLCFNCEACKAGFIDNLKSSWKKVAVVNIVFLIFLIVVYSVGCCAFRNSRRDNDYHQGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSK2</accession>
    <name>A0A0D2RSK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Syntaxin 6/10/61 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G031400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Golgi apparatus</location>
            <location evidence="8">trans-Golgi network membrane</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSK2"/>
    <dbReference type="SMR" id="A0A0D2RSK2"/>
    <dbReference type="STRING" id="29730.A0A0D2RSK2"/>
    <dbReference type="Gramene" id="KJB22105">
        <property type="protein sequence ID" value="KJB22105"/>
        <property type="gene ID" value="B456_004G031400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22106">
        <property type="protein sequence ID" value="KJB22106"/>
        <property type="gene ID" value="B456_004G031400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790231"/>
    <dbReference type="eggNOG" id="ENOG502QVDF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYDMPNH"/>
    <dbReference type="OrthoDB" id="1889309at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21442">
        <property type="entry name" value="SNARE_NTD_STX6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000004">
        <property type="entry name" value="Syntaxin 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34949">
        <property type="entry name" value="OS05G0443700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34949:SF3">
        <property type="entry name" value="OS08G0244100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Syntaxin 6/10/61 N-terminal" evidence="11">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB22105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="326" mass="36628" checksum="27DF271DB586A44F" modified="2015-04-29" version="1">MMVANSFDLWKKDAFFSAAEEVQESADIMESAYRMWIKERKEGLRTGDSVELCRELQTALGTAKWQLEEFERAIRLSHGHCSDDITATRHKQFISAIESQISHVEAALKEAFIEEGKQPLRWVNLDEEECDDLAIFLSGTSPSLLQPSTKNTLSENCQKRKDTDSNNATCNGDTSEVQMTKVFKDSGKDAECIIDVEDGESSGRSNDVSCGLERTTGTRKTWCSPNLGTLNIVIADKYNDRTKTRSGIESTPKEKGSKPFFRKQRCGDLPQAKGAFNLFYQRFGWISGLLRHLQSPVHLQFSCSLQLTLALLIAIFLIVPFVLYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S400</accession>
    <name>A0A0D2S400_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">B456_006G157700</name>
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    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_006G157700"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48465:SF1">
        <property type="entry name" value="PROTEIN SSUH2 HOMOLOG"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB36401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="131" mass="14738" checksum="B8E4C19DE54A00C7" modified="2015-04-29" version="1" fragment="single">EEKRIEIDENERLSSYQYVGRTGSVIPTASLPGTDVSIEEIRSATSFSTPYPPSIHAPLISSPEPLPNEQAIPHQSPYATDYGTYSNDFQRQLLDEVEIRELLIDHIGYQCCWGSCPARTWKIHAVEDCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SA09</accession>
    <name>A0A0D2SA09_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Pentatricopeptide repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G074200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB79952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2SA09"/>
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        <property type="gene ID" value="B456_013G074200"/>
    </dbReference>
    <dbReference type="OMA" id="VISAYTC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
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        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB79952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8949" checksum="B445AA0F75DB9788" modified="2015-04-29" version="1">MGIMKRGFDSDNVIMTALIDFYGRNGQLNEVCQMFDELPEPDAICLDSVISAYTCDNFDSLWEFRVVEVGEASACAGHYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SD15</accession>
    <name>A0A0D2SD15_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bax inhibitor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G029900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SD15"/>
    <dbReference type="STRING" id="29730.A0A0D2SD15"/>
    <dbReference type="Gramene" id="KJB39761">
        <property type="protein sequence ID" value="KJB39761"/>
        <property type="gene ID" value="B456_007G029900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801977"/>
    <dbReference type="eggNOG" id="KOG1629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALCQMHE"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB39761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="27229" checksum="A8F2974DA4806841" modified="2015-04-29" version="1">MDAFTSFFDSQSRNIWSYDTLKNFRQISPIVQTHLKQVYLTLCCALIASAVGAYLHILWNIGGYLTTFACLGTIIWLLSTPPCEEQKRVSLLMASAVFEGASIGPLIDLAIQIDPSVLVASFVGTALAFACFSGAAMLARRREYLYLGGLLSSGVSVLLWLHFASSIFGGSTALFMTEIYLGLLVFVGYMIVDTQDIIEKAHLGDLDYVKHALTLFTDFVAVFVRILIIMLKNSAEKSEKKKKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDE7</accession>
    <name>A0A0D2SDE7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="1">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G131500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB81152.1"/>
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    <dbReference type="Gramene" id="KJB81152">
        <property type="protein sequence ID" value="KJB81152"/>
        <property type="gene ID" value="B456_013G131500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KIACWFI"/>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="Dynamin"/>
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    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF169">
        <property type="entry name" value="DYNAMIN-LIKE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB81152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="129" mass="14747" checksum="07E0AA38D9885BC3" modified="2015-04-29" version="1">MSYRFEFALSSQSDGKSSLIKALLGFHFNVREIEMGTRQPLILQMVHYRSTLEPRCRFQEEDSKEYGSPVVSASTIADVIKSRTEALLKKTKTSVFPKPIVMKAEFAHCPNLTVIDTPRFDLKIACWFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDJ9</accession>
    <name>A0A0D2SDJ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G037500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB39911">
        <property type="protein sequence ID" value="KJB39911"/>
        <property type="gene ID" value="B456_007G037500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000146">
        <property type="entry name" value="RING/FYVE/PHD zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3675"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033275">
        <property type="entry name" value="MARCH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23012:SF215">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12428">
        <property type="entry name" value="DUF3675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="258"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB39911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="38711" checksum="8ABB1594F3B79887" modified="2015-04-29" version="1">MSDHLVVCVDRLTKPESLKSVNEPEVAGPSGEGSSVVAEPHVCAIDVEEVEEHGSCDEEEPLIQTVECRICQDEDNINNLETPCSCSGSLKFAHRKCVQRWCNEKGDITCEICHQPYQPGYTVPPPPPQPEVATIDISEWTVAGAPLGLHDQRILAVAAEHRILEQGYDEYAEPDSSGTEFFRAAALTLMALLFLRHALYLTSGEEDDDLSRFISLFLLRAAGFLLPCYIVAWAISILQRRRQRQATRPRSIHYSIAAGPSVTHQQEQPQSIHYSVAPGPSTAPQPEQPLTIHYSIAAPGPSAIPQQEQPQAMHYSVAASGPSVTPQQDQPLTIHYSITAPGPSATTQQEPAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SEJ1</accession>
    <name>A0A0D2SEJ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CBM20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G165100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in intercistronic processing of primary transcripts from chloroplast operons. The endonucleolytic activity of the enzyme depends on the number of phosphates at the 5' end, is inhibited by structured RNA, and preferentially cleaves A/U-rich sequences.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase E/G family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SEJ1"/>
    <dbReference type="STRING" id="29730.A0A0D2SEJ1"/>
    <dbReference type="Gramene" id="KJB42719">
        <property type="protein sequence ID" value="KJB42719"/>
        <property type="gene ID" value="B456_007G165100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPXM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRDSWMR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010239">
        <property type="term" value="P:chloroplast mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901259">
        <property type="term" value="P:chloroplast rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:001568">
        <property type="entry name" value="Ribonuclease E/G-like protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1260.20">
        <property type="entry name" value="Ribonuclease E, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001:SF1">
        <property type="entry name" value="RIBONUCLEASE E_G-LIKE PROTEIN, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CBM20" evidence="11">
        <location>
            <begin position="76"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="999" mass="111422" checksum="D037F41588821F62" modified="2015-04-29" version="1">MDVLEAWPRPPPPPRPCTLFLPRTPSCLIRSFNFLSPFPGHHIPLGSVFRFTLCAANHNSLTRSPVMSAKKGLSTATFEGLCEVVWTVEADLAEGQLLYISGEPVALGCWKPETAILMSPTEHANIWMAEVKIAGGVNFKYNYFIKGEKQPLSDITWRPGPQFSLSVPPRKKPERKIIVRDSWMSPKSETYLPHAWGSWIEEISTPIKPSVSQAEDEDKIMKHHESDLSEAKPFLNDLIGMDEIEPSDMVAISDAEEGLYSTISERDQPVEEPWFLHSPLSFLSYGDGMEANSAKDEKTRLEANNQHDQITEKFLSEENSRLIFKDSVSTVILINSSICTMQRIAVLEDGKLVELLLEPVKSHVQCDSVYLGVVTKLVPHMGGAFVNIGSSRHSLMDIKHNREPFIFPPFRQRKKKQAKDFASGSLSEPSAANEIEPSSEDVFFEDAAEDDFEDEDMQFMHNNSDGNDVGDDFDVLGVLKENVNGSVVDYGEVDADFEDLLDGEHHLEGNLIGASSLEMSNSCSVSHSQDIEGADENKWHHVRKGTKIIVQVVKEGLGTKGPTLTPYPKLRSRFWILLACCDRIGVSKKITGVERTRLKVIAKTLQPQGFGLTVRTVATGRSLEELQKDLEGLLSTWKNIVEHAKSAALAADEGVEGATPVLLHRAMGQTLSVVQDYFNDNVNKMVVDSPRTYHEVTNYLQDIAPDLCDRVELYDKRIPLFDAFNIEEEINSILSKRVPLPNGGSLVIEQTEALVSIDVNGGHGMFGHGTSQEKATLDVNLAAAKQIARELRLRDIGGIIVVDFIDMADDSNKRLVYEEVKKAVERDRSMVKVSELSKHGLMEITRKRVRPSVTFMVSEPCTCCHGTGRVEALETSFSKIEQEIGRLLAVMKQKTHPENPKSWPRFILRVDQHMCNYLTSGKRTRLAILSSSLKVWILLKVARGFTRGAFELKPFTEEKAGKNQHQVAISMLRTAEAGTSKSGKKLTLVPVKRAKVDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGX0</accession>
    <name>A0A0D2SGX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_013G196000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. Cation/calcium exchanger (CCX) subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB82447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2SGX0"/>
    <dbReference type="Gramene" id="KJB82447">
        <property type="protein sequence ID" value="KJB82447"/>
        <property type="gene ID" value="B456_013G196000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783234"/>
    <dbReference type="eggNOG" id="KOG2399">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLQIVLT"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF18">
        <property type="entry name" value="CATION_CALCIUM EXCHANGER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="107"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="13">
        <location>
            <begin position="411"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB82447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="568" mass="62551" checksum="C8C5DA06E150F4AC" modified="2015-04-29" version="1">MGTWVLQYQNKRFILILMNISFLLVASVFLMMCSSSSQVVLGSNGSKFRNSQQDCKALEDLDDYKAKCSYLKSNNNPCVYQGYVDYLYHFYCNFGRFPVLGLCLLIAWLIVLFYLLGNTASEYFCYSLESLSSLLKLSPTLAGVTLLSLGNGAPDVFSSVVSFMDSATQDVGLNTVLGGVFFVTCIVVGMIGTFVHRKRVAVNKPAFVRDVCYLLLVLVSLILILIKGEINLWGAMAFSSMYIVYVILVYIIYIVWNSGGRDITDSDSSYNSGLNIPILNGIDKVEIDYLEEGDVKDVKGDEFKNCCLCLRISDTWSVLLWVLEMPLYLPRRLTIPIACQERWSKPVAVVSVTFAPILLSVLWDLQDDNLTFKTGLVVYGIGVLFGISFGFLAYLRTEKSSPPKTCLFPWLAGGFLMSVVWSYIIAQELVGLLISLGHILGISQSILGFTVLAWGNSLGDIVTNLTMALNGGPEGVQVAISGCYAGPIFNTLFGLGMSLVGSAWHGYPSPVQIPKDPYLLETLGFLVAALLWALLVLPMRNMKLDGVLGGGLFLIYFTSMSLRVIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SIV1</accession>
    <name>A0A0D2SIV1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G232200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB83162"/>
        <property type="gene ID" value="B456_013G232200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNALSEW"/>
    <dbReference type="OrthoDB" id="2018467at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
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        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Apaf_helical"/>
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    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF67">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="170"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="430"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="9">
        <location>
            <begin position="564"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="7">
        <location>
            <begin position="685"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB83162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="98452" checksum="42384B000C92B418" modified="2015-04-29" version="1">MAETFLFNIAERVLAKIGNLSVDEVRLAFNVKTDLKKLEDTMISIKAVLLDAERQQHQNEKLCLCMWKLGDIFYDAEDVIDDFKCEALWKQDAINHPDINNLKVRLLGSCCLPLSFYLKMSHKIKDINGRLGELATEWKSFDLRQCSDNRHVFRRETISFVDSSDVIGRDEDKKNIISMLMKPSEARNVPVIPIVGIGGLGKTTLAQLVYNDDRVTSLFPLKIWICVSEEFDLSRLLRLIIQSVNTGERCDDSTLDALQARLRSLLTDKKFLLVLDDVWNENKAKWVELRNLLRSIDGLPQSKIIVTTRSLKVSSIMSSICPYELKGLSFEDCLTLFTKWAFNDGDERHYPNLIRIGEEIVKKCKGVPLAVRTLGSLLFQKTDESDWIYIRESEIWRVEQHENDILPVLKLSYNHLPSHLQRCLAFLSLYKKDEIYFSYRVINLWMANGLLEHPKQNQEWEDVGKRYLNELLSRCLIQMDQDYGLIFTFKMHDLVHDLALDVSQKECKTVNSETETVDENVRHLLLCDEKLVGVPRVLEEMKNVRTVIIQDASKESKTTHESLINLCLSNFKYLRALELRKSPLMALPNSIGTLKHLRDLDLVGCSSIRELPRSFDKLRSLQSLNLGGTSLKQLPDSVQRLIELRHLVITIKATHLKEIRAGCWTSLQYLELRSCMELKCLPEGMQYLKSLRTLVLGGCDKLVSLPRSLKLLTKLEHLYINFCASMNLKMEPEEEEDKDLQLILKTLSLFGLDALRDLPRLLLQGSSCTLQQLRIRGCPNLSVLPAWLPNLTSLQELEIVNCIKLSAQPEGIDRLSNLRELTIHLCPELSKRYRENGGEDWHKIAHIQKVVITDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJ79</accession>
    <name>A0A0D2SJ79_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-oxoglutarate-dependent dioxygenase DAO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein DIOXYGENASE FOR AUXIN OXIDATION</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G239800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">2-oxoglutarate-dependent dioxygenase essential for auxin catabolism and maintenance of auxin homeostasis in reproductive organs. Catalyzes the irreversible oxidation of indole-3-acetic acid (IAA) to the biologically inactive 2-oxoindole-3-acetic acid (OxIAA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJ79"/>
    <dbReference type="STRING" id="29730.A0A0D2SJ79"/>
    <dbReference type="Gramene" id="KJB83287">
        <property type="protein sequence ID" value="KJB83287"/>
        <property type="gene ID" value="B456_013G239800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:128031846"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKQCEEP"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000017">
        <property type="entry name" value="2-oxoglutarate-dependent dioxygenase DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="162"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00054658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00076740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="322" mass="36741" checksum="A1C4FA2B99F00A85" modified="2015-04-29" version="1">MAVDAEIELPTIEFRSSDLKRGTEGWNRLCKRVREACETFGCFDVVYKKISTKIREDAFELLKELVEVPVERKQKNTSPLPYHGWVGPCEQVSVLYEGFGVGDASNYDSVKSFAQLMWPNGHPRFTETIHTLTTQIEELNKLIWLMLTDSYGLREDSLKMNYTTLVRMMKYLAPPPGEYERGLFAHTDKPVSTLICEDKISGLEIEVSDGQWIKLTNLSPSSFVFMVGDPLKAWSNGRLKSVNHRVMMSGDKDRYSIAAFVIPNEGTIIKAPKELIDDQHPQLFKEFDFMDFFLYAFSDPAKHIDNGQLLYSYASLSPPVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJE4</accession>
    <name>A0A0D2SJE4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G242800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJE4"/>
    <dbReference type="STRING" id="29730.A0A0D2SJE4"/>
    <dbReference type="Gramene" id="KJB83352">
        <property type="protein sequence ID" value="KJB83352"/>
        <property type="gene ID" value="B456_013G242800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782916"/>
    <dbReference type="eggNOG" id="ENOG502QWG4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMGERTM"/>
    <dbReference type="OrthoDB" id="623055at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000096">
        <property type="entry name" value="Basic helix-loop-helix (BHLH) DNA-binding superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051358">
        <property type="entry name" value="TF_AMS/ICE1/BHLH6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31945">
        <property type="entry name" value="TRANSCRIPTION FACTOR SCREAM2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="51"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB83352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="245" mass="27807" checksum="C66B87DDAA160576" modified="2015-04-29" version="1">MLAMENIENIGDEYKNYWETKYFLENEEYSWPIDEFSGYYDSSSPDGAASSVAAKNIVSERNRRKKLNERLFALRAVVPNISKMDKASIIKDAIDYIQELHDQEGRIQAEISELESGKLKKNPGFEYDQELPGLRSKKTKLDNIFDYGGSRACPIEVLELKVTHMGERTMVVSITCSKKTDTMVRLCEVFESLKLKIITANITAVSGKLLKTVFVEADEREKDELKVQIETAIAALNDPQSPMSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJQ7</accession>
    <name>A0A0D2SJQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G189300</name>
        <name evidence="8" type="ORF">Gorai_017059</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJQ7"/>
    <dbReference type="Gramene" id="KJB31395">
        <property type="protein sequence ID" value="KJB31395"/>
        <property type="gene ID" value="B456_005G189300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794731"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCSHCPW"/>
    <dbReference type="OrthoDB" id="635774at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000736">
        <property type="entry name" value="Putative serine/threonine-protein kinase At1g18390 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008">
        <property type="entry name" value="LEAF RUST 10 DISEASE-RESISTANCE LOCUS RECEPTOR-LIKE PROTEIN KINASE-LIKE 1.4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46008:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715718" description="Protein kinase domain-containing protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="319"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0586315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="635" mass="70566" checksum="57A543CAE6707C3E" modified="2015-04-29" version="1">MPSPSPPSISLLLLTTIFFISFEWVVTEAATLPHHPCSSTSPCPPFTSPPPFPFSFSAGCGHPSFPINCSTPSSTISINNLSFSLLYFDPNSTSLTLSPLPPTTTSPCSSFNFLHINLSGSPFRISDASCSRLSILRSCSPSNLSNCDQCAWECGIIKHPLKLFPDCGPTRQLPEQGCQPDVLGYLQNFFFKMGFQVEWDEAQDSYFSSCRDCKLKNGICGFNSSDPNKPFLCFQAKATISPTLIHVDHTHRIAILSSVLTLTCIFLIFSVTFVFFRSKKFKSQSVEDPTALFLRRHRSASLLPPVFTYEELESSTNKFDPERKIGDGGFGSVYLGQLHDNRIVAVKYLHKNNQSGNALSSKFFCNEILILSSINHPNLVKLHGYCSDPRGLLLVYDYVPNGTLADHLHGRPKPSLSWPVRLEIALQTALAIEYLHFSVVPPIVHRDVTTSNIFVEKDMRIKVGDFGLSRLLAFPENSSLKSEFVWTGPQGTPGYLDPDYHRSFRLTEKSDVYSFGVVLLELISGLKAVDQRREKREMALADLVVSKIQMGLLHQVVDPALILDGQPMDGVEAVAELAFRCVAADKDDRPDAREIVGELKRIKNRTRVLRLSYSNGSNGEVAKDDNIGMFDVTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SM67</accession>
    <name>A0A0D2SM67_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G037900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL41 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SM67"/>
    <dbReference type="SMR" id="A0A0D2SM67"/>
    <dbReference type="STRING" id="29730.A0A0D2SM67"/>
    <dbReference type="Gramene" id="KJB64218">
        <property type="protein sequence ID" value="KJB64218"/>
        <property type="gene ID" value="B456_010G037900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773905"/>
    <dbReference type="eggNOG" id="KOG4756">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRNEGVH"/>
    <dbReference type="OrthoDB" id="408933at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019189">
        <property type="entry name" value="Ribosomal_mL41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21338">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09809">
        <property type="entry name" value="MRP-L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="92" mass="10340" checksum="9C758ACD433378BC" modified="2015-04-29" version="1">MPLGLILGIGRTFRRKRTSSLDILSSKRAPRDYYKGKNCKSTGFHTRKGGYVVMQEKLPNYVVPDLTDFKLKPYVSQCPTEVKTAEAAESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SR41</accession>
    <name>A0A0D2SR41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="16">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_007G373100</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="16">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="16">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="16">Binds 2 divalent ions per subunit. The metal ions interact primarily with the substrate. Can utilize magnesium, manganese or cobalt (in vitro).</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="16"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SR41"/>
    <dbReference type="STRING" id="29730.A0A0D2SR41"/>
    <dbReference type="Gramene" id="KJB46509">
        <property type="protein sequence ID" value="KJB46509"/>
        <property type="gene ID" value="B456_007G373100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761800"/>
    <dbReference type="eggNOG" id="KOG1506">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKGLLEH"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="18">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="19">
        <location>
            <begin position="117"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="20">
        <location>
            <begin position="240"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB46509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="390" mass="42630" checksum="CE4613006251EF1E" modified="2015-04-29" version="1">MDTFLFTSESVNEGHPDKICDQVSDAILDACLEQDPESKVACETCTKTNMVMVFGEITTKAKVNYEKIIRDTCRGIGFTSADVGLDADKCNVLVNIEQQSPDIAQGVHGHLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGAKLTEVRKNKTCPWLRPDGKTQVTVEYQNDGGAMVPVRVHTVLISTQHDETVTNEKIAADLKEHVIKPVIPAKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVASGLARRCIVQVSYAIGVPEPLSVFVDTYKTGKISDKDILELINKNFDFRPGMISINLDLKRGGKFRYQKTAAYGHFGRDDPDFTWEIVKPLKPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUW7</accession>
    <name>A0A0D2SUW7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AT hook motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G179900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUW7"/>
    <dbReference type="STRING" id="29730.A0A0D2SUW7"/>
    <dbReference type="Gramene" id="KJB67203">
        <property type="protein sequence ID" value="KJB67203"/>
        <property type="gene ID" value="B456_010G179900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773089"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LIPRCTE"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045881">
        <property type="entry name" value="MNM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34682">
        <property type="entry name" value="AT HOOK MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34682:SF3">
        <property type="entry name" value="AT HOOK MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB67203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="48105" checksum="2A6DFCFE997ABA9E" modified="2015-04-29" version="1">MSKIFGLLTLLNIIILIIDLTPIFFTQLIWILESPTEQRMSSKNQGVSLTSSAEPPMKRKRGDYTPATPESDNLKRNKQSAWISDPASSDMLGQMVSGVIEGSFDAGYVLQVKVGDTNTHLRGLVFLPGLFAPITNANDVAPHAKMHKRKDIPIPFVNLHGHLHVLSSSGNSEKPVEQKNDTSNRPDRGLHMGLEPGASVAGESQFASILIPPASNLPINEAGLPLRQKVMQEQSSDSGLHNEKAVGQHQSLEGFEAFKQMKGPSINVEATKASELSAEFAATLQATDTINLKPQIQYKALSSELKPPALIHDHDTISFDIGDNQTPQISEPEPQAMACDAGINMFGKQASSRQDTQSELGQKYMDGLFASDDVTTSATAPCSAPMTSLQVMIFEADTIPFEPKSGAEESVLPTMVVPEVNSSLVTTANTYSVESNAKDATPTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SWT9</accession>
    <name>A0A0D2SWT9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G372500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Intracellular vesicle trafficking and protein transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SWT9"/>
    <dbReference type="STRING" id="29730.A0A0D2SWT9"/>
    <dbReference type="Gramene" id="KJB46501">
        <property type="protein sequence ID" value="KJB46501"/>
        <property type="gene ID" value="B456_007G372500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761798"/>
    <dbReference type="eggNOG" id="KOG0080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IIFAYDV"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01863">
        <property type="entry name" value="Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000456">
        <property type="entry name" value="Ras-related protein RABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB46501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="217" mass="23695" checksum="17106A60C5E21A49" modified="2015-04-29" version="1">MGSSSEQQSSENYDFAFKILSIGDSGVGKTSLIASFISAFSQYSAPTIGVDFKIKFLTVGGKRLKLTIWDTAGQERFRTLTSSYYRGAHGIIFAYDVTRRETFTNLSDVWAKEVELYSTNQDCVKILVGNKIDRESERAVSKEEGIELAKELGCTFIECSAKTGQNVQQCFEDLSLKIMEVPSLLEKGSIGGKGDILKPKPENPVAPPPPPVGGCCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TE75</accession>
    <name>A0A0D2TE75_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_008G280900</name>
        <name evidence="18" type="ORF">Gorai_010621</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TE75"/>
    <dbReference type="SMR" id="A0A0D2TE75"/>
    <dbReference type="STRING" id="29730.A0A0D2TE75"/>
    <dbReference type="Gramene" id="KJB52871">
        <property type="protein sequence ID" value="KJB52871"/>
        <property type="gene ID" value="B456_008G280900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765575"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000668">
        <property type="entry name" value="Phosphoenolpyruvate carboxylase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="42"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB52871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0593686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="510" mass="56196" checksum="B2A43FFE2434D758" modified="2015-04-29" version="1">MAVAKSSSFNETSKQPCNCYKVASLSETILETGQTANLKDRYILGEQLGWGQFGVIRLCSDKLTREVLACKSISKDRLVTSDDARSVKLEIEIMTRLSGHPNVVDLKAVYEDEDYVHLVMELCAGGELFHRLEKYGRFYEADARVLFRHLMQVVLYCHEIGIVHRDLKPENILLATKASSSPIKLADFGLATYIEPGKCLHGTVGSPFYIAPEVLAGGYNQAADIWSAGVILYILLSGTPPFWGKTKSRIFDAVRAADLQFPSDPWDRISDSAKNLVRGMLNTDPSQRFTALQVLDHLWMKYDESCHEESSEFVYQSHGELEFHSGSFSLSRDQDISFGAGSPIIYDVQSPSLTCRTSFSSSLVEPSTTCFALGGFSFHGGNSETLEFSSAVPSMPSFAFFSPSSVAEQENIALVERFAGDTGLDKLLVLPDSSLSCGPEAREKETKTAEFGRTGGMNGSKLLAFHSKRNRTIGHGEREQLDFIVSESVIRWASCTNLPTATSLRSSLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKC6</accession>
    <name>A0A0D2TKC6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G238300</name>
        <name evidence="6" type="ORF">Gorai_019407</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKC6"/>
    <dbReference type="STRING" id="29730.A0A0D2TKC6"/>
    <dbReference type="Gramene" id="KJB44165">
        <property type="protein sequence ID" value="KJB44165"/>
        <property type="gene ID" value="B456_007G238300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801564"/>
    <dbReference type="eggNOG" id="ENOG502RZHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFCEEIN"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB44165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0590712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="189" mass="20832" checksum="BC083C49E87B0327" modified="2015-04-29" version="1">MATIFSICLLFTLYYITFSTFYSTVSGIFCEEINEGIAIKRLEKRSHLHFYFHDVISGKKPSAVKIAGPPNSSAYGFGATMMMDDALTEGPEISSKLVGRAQGMYALAAQEDVSLLMVMNLAFTEGTYNGSSISVVGRNPVFDDVREMPIVGGSGVFRFGRGYALAHTIWFDYNTGDATVEYNVYVSHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TLD5</accession>
    <name>A0A0D2TLD5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleotide-diphospho-sugar transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G076700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TLD5"/>
    <dbReference type="STRING" id="29730.A0A0D2TLD5"/>
    <dbReference type="Gramene" id="KJB55446">
        <property type="protein sequence ID" value="KJB55446"/>
        <property type="gene ID" value="B456_009G076700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769759"/>
    <dbReference type="eggNOG" id="ENOG502QR4V">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267939" description="Nucleotide-diphospho-sugar transferase domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB55446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="616" mass="70779" checksum="0B8A1A5FD788BF1B" modified="2015-04-29" version="1">MGPPKKHFVPFLLLLAFCVLLLLYSPRPNSISTQFPLNPHSIASSAATSTSASSTFSLTIKVLTFNRLNSLTRCLTSLSKAHYHPDHPVHLHIFVDHFPNQTQSDIDLKLQESLGILRFVDGFQWKWGQKVVHYRTTNVGLQAQWLEAWWPTSDDEFAFVVEDDLELSPLFFKYLRALILNYYYNASNFSPFVYGASLQRPRFVPGKHGNKMLLEKTSGLFLYQLVGTWGQLLFPKPWKEFRLWYDDHRAKGIKPFLDGMISTGWYKKMGERIWSPWFIKFIHSRGYFNIYTKFPDEKSLSVSHRDAGVNYGKTAGPDSQLLDENSLDSDFPEMKSLSTMKKYDFCFREVVSGRIVWSLNDLGSILPSVQKKEAVLLVSLFGVSETVTRNLLCHFERLNIWNYIFIGPAAEFLFHLAQGGHPVIDADGFLEDIKSFKSLRIKESNARLIKEILLKAYVVKKGLELGYNTWVVDGNMVFIDNEFFLDPMDNFYAGESLDLFYVKNSPSAHKIWTHDFLHDVAAMVDKIALPSDTLNFASVMAKLVGQKGIRFKRIDEKSFGMKIGNQNLNQALETNKKVVYWFRELDMNSIQKHLQEMSLWVIDNDSSCRAVVCHNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TMD2</accession>
    <name>A0A0D2TMD2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G097000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TMD2"/>
    <dbReference type="STRING" id="29730.A0A0D2TMD2"/>
    <dbReference type="Gramene" id="KJB55831">
        <property type="protein sequence ID" value="KJB55831"/>
        <property type="gene ID" value="B456_009G097000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RKNNTEP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001103">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000682">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g16610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000488">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF342">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="4">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="5">
        <location>
            <begin position="677"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB55831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="754" mass="84331" checksum="EAD9C47BA9816D2D" modified="2015-04-29" version="1">MASISKICLYKPFSLSFAGSVKDQTLLQRCNFPATCILREQVPLKNECRVFARMPERTGTGVSTYLRETGTGENGDYARNDLDISHLISVLKFCGGEGCLEFGRTYHGLIAKTGLDGDEFVNTSLIDMYAKCGDIDSAVMVFNQMPRLDVASCNCLISGYANCGLFEEAFRLFMNYESWGNKPNSYTYSSMLAICGTLSAIEEGKQLHAQVVKMQYLSETAVSNALLTMYCKCEAMADAESLFERLPQRNIVSWTAIIHGLYQHEGFEKAMRLCCLMRESGIEPNDYTFTIALASCGNMKNIDNCRLLHGLVIKKGMALGEFVGTALIDMYSELRETDDAEKQFKEMGNLTSKVSRNALIKGLVQNEKANEALDAFSEMVRKDAACDEFTFSPILKACASLPSFMSCQQIHAQVVKANFDKNTHVGSSLIEAYTRCGSVEDAEKVFSRISAPDVVSWNSVIKAYSQNGNPRRAISLFRRMIIKGFRPTGSTFLAVLSACSHSGKIQDGQEIFQSMINEFGVSPEEAHYSCMVDLLGRSGQIEKALDFINNTPIKPTASIWRPLLAACRCHNNLRIAEFAAKHILAMDPNDATVYVTLSNMYIEAGLLENAENQRKLMKLKEITKEPGCSWIEVNNKIHKFFSRDRTHPESEKIYDKLKQIMMLIKGTAYSTNADSLQVKEDFCLYHSEKLAVCFGLISLAAGKPVRIFKNLRVCTDCHMFMKFASMITDRVIILSDNYRFHHFNKGGCSCGDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TME6</accession>
    <name>A0A0D2TME6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G188400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TME6"/>
    <dbReference type="STRING" id="29730.A0A0D2TME6"/>
    <dbReference type="Gramene" id="KJB57974">
        <property type="protein sequence ID" value="KJB57974"/>
        <property type="gene ID" value="B456_009G188400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PQFSHHI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004320">
        <property type="entry name" value="BPS1_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070">
        <property type="entry name" value="OS06G0725500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070:SF49">
        <property type="entry name" value="OS06G0725500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03087">
        <property type="entry name" value="BPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB57974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="264" mass="30404" checksum="E7507173FC419E25" modified="2015-04-29" version="1">MVGVFRRSLSFPNKTLTRPPKPQFSHHIRSISLPCRSHPLITRIKDEITDLKTWSRSPEKPTSAWLCDGLRRLKDLQDSLHDILQLPQTQQLLSHKREWVEKLLEDFLRFVDVYGIFQTSFLSLKEEQLAARVALRRKDDSRIAVYLKGRKKMAKEIAKLVSSIRYIGRYSFPASAFVSILDTELTGVISDIIEVTVSVSVALFNGISMAFTSSKSSWIRLALTKKSNKVKIEGRRRGSEDGFGENARLGKVHCWYRKWKRQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TP29</accession>
    <name>A0A0D2TP29_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G135000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TP29"/>
    <dbReference type="Gramene" id="KJB77388">
        <property type="protein sequence ID" value="KJB77388"/>
        <property type="gene ID" value="B456_012G135000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="11323" checksum="34EA8B1AD3B7CAFE" modified="2015-04-29" version="1">MMKGKEKLSNESATKPSGVSITQSPTLPSLPPRNRSDTISRRFGANESEWSSDEEEDVYADDNNQQILIQDFRRHLQETHQTIQEMMKIQRWKPFAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQX0</accession>
    <name>A0A0D2TQX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein transport protein Sec24-like At4g32640</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G246400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQX0"/>
    <dbReference type="STRING" id="29730.A0A0D2TQX0"/>
    <dbReference type="Gramene" id="KJB59249">
        <property type="protein sequence ID" value="KJB59249"/>
        <property type="gene ID" value="B456_009G246400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59253">
        <property type="protein sequence ID" value="KJB59253"/>
        <property type="gene ID" value="B456_009G246400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59254">
        <property type="protein sequence ID" value="KJB59254"/>
        <property type="gene ID" value="B456_009G246400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769670"/>
    <dbReference type="eggNOG" id="KOG1984">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01479">
        <property type="entry name" value="Sec24-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
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    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
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    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041742">
        <property type="entry name" value="Sec24-like_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="6">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="7">
        <location>
            <begin position="514"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="9">
        <location>
            <begin position="759"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="8">
        <location>
            <begin position="854"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB59254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1104" mass="118865" checksum="FC35259D460B55C1" modified="2015-04-29" version="1">MAAPVPPGAPRPGANARQQSPHPNFNPNFQTNPNSLADNMQNMNLNRPHSMPNSGPRPSPFGQPPPFPQSSVTAGFPVASPPMSRPGPPPGMVGRPAVIPAGPLQSTLPANVPPGRPVGLPVSHPLPFGSRPPPASLSSSTGGAVLPSSAFPSSGVSSASAAPPPPGTRPSSFVSSSPLTGGPAGPMSSARAGPSSNGPPAVGAGALPGAPQFPPPAIVSQPPVGPPPSMMSARAPAQAPTMRSVLGSSAVSSPQTPPLPSASSPFPAMTQARPPPPGSPYGPQTWSMQPQQGTQPPHIPGSTHAQPPRMFGMPQQALPNQAMTNIPPALGQPGAPMSGSSKIDPNQIPRPIPNATPIVYETRHGNSANPPPPATSDYIVRDTGNCSPRYMRCTINQIPCTGDLLTTSAMQLALLVQPMALPHPSEDPIQVVDFGESGPVRCSRCKGYINPFMKFIDQGRKFICNLCGFTDDTPRDYHCNLGPDGRRRDADERPELCRGTVEFVASKEYMVRDPMPAVYFFLIDVSMNAVQTGATAAACSAINQVISDLPEGTRTQVGIATFDSTIHFYNLKRALQQPLMLIVPDIQDVYTPLETDVIVQLSECRQHLELLLENIPTMFQTSTTAESCFGAAIKAAFLAMKSIGGKLLVFQSVLPSVGIGALSSREAEGRTNISASEKEAHKLLQPADKILKTMAIEFAEYQVCVDVFVTTQTYVDIASISVIPRTTGGQVYYYYPFSAVSDPAKLYNDLRWNITRPQGFEAVMRVRCSQGIQVQDYSGNFCKRIPTDVDLAGIDCDKCILVTLKHDDKLQDGSECGFQCALLYTTVYGQRRIRVTNLSLPCTNMLSNLFRSADLDTQFTCFLKQAAIEIPTCPLLQVRDHVTNLCINILLSYRKFCATVSSTGQLILPEALKLLPLYTLALIKSRGLRNDGRIDDRSFWFNYVSSLSTPLAIPLVYPRMFAIHNVDTKDGDESVLPPTIPLSSEHVCDDGIYLLENGEDALIYFGSSVDSSILQQLFGFTSVDEVPTQFVMQQFSNPLSKNFNDVVNVIRQQRCSYLRFALCKKGDPSGMAFLSCMVEDKNANGPSYVEFLVHIHRQIQMKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTT0</accession>
    <name>A0A0D2TTT0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transducin/WD40 repeat-like superfamily protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G291800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTT0"/>
    <dbReference type="STRING" id="29730.A0A0D2TTT0"/>
    <dbReference type="Gramene" id="KJB60148">
        <property type="protein sequence ID" value="KJB60148"/>
        <property type="gene ID" value="B456_009G291800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60149">
        <property type="protein sequence ID" value="KJB60149"/>
        <property type="gene ID" value="B456_009G291800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770372"/>
    <dbReference type="eggNOG" id="ENOG502QS54">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPKVDEC"/>
    <dbReference type="OrthoDB" id="336008at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057221">
        <property type="entry name" value="DUF7899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789">
        <property type="entry name" value="OS05G0482600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31789:SF1">
        <property type="entry name" value="OS05G0482600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25463">
        <property type="entry name" value="DUF7899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54161" checksum="6EC8B3E55A054CD8" modified="2015-04-29" version="1">MDGGRRIAVSPRPCSGRRILASKKRGRPDAFVNSVKKLQRREICSKPHRAFSVTDAQERFRNIRLQEEYDTHDPKGHCSMVLPFLRKRSKIIEIVAAQDIVFALAQSGVCAAFSRETNRRICFLNVTADEVIRSLFYNKNNDSLITVSVYASDNFSSLKCRSTRIEYIRRGQPDAGFALFESESLKWPGFVEFDDVNGKVLTYSAQDSIYKVFDLKNYTMLYSISDKNVQEIKISPGIMLLIFTKVGGHVPLKILSIEDGTVLKSFSHLLHRNKKVDFIEQFNEKLLVKQENENLQILDVRNSELTEVSKNEFMTPSAFIFLYENQLFLTFRNRTVAVWNFRGELVTSFEDHLLWHPDCNTNNIYITSDQDLIISYCKADSDDPLSEGNGSINISNILTGKCLAKIRASNGFPVEKQCSCCDVECGCRSKVQSSSSRIRSTVAEALEDITALFYDEERNEIYTGNRYGLVHVWSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TV12</accession>
    <name>A0A0D2TV12_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G012300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TV12"/>
    <dbReference type="STRING" id="29730.A0A0D2TV12"/>
    <dbReference type="Gramene" id="KJB47140">
        <property type="protein sequence ID" value="KJB47140"/>
        <property type="gene ID" value="B456_008G012300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762686"/>
    <dbReference type="eggNOG" id="KOG0475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTALSME"/>
    <dbReference type="OrthoDB" id="4564at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034707">
        <property type="term" value="C:chloride channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04592">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00400">
        <property type="entry name" value="Voltage_gated_ClC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000066">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050368">
        <property type="entry name" value="ClC-type_chloride_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43427:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN CLC-E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0868">Chloride</keyword>
    <keyword evidence="8" id="KW-0869">Chloride channel</keyword>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="478"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="567"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB47140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="720" mass="76916" checksum="2F045D9970018660" modified="2015-04-29" version="1">MALASVLRLFPSSPPHLSPLLCKSPPPFPFNSNRFSSSPFPILNQRSSFVTAALPDSADEQTVVSVDSVVSEDNFNDPRVIVSACLVGVFTGIAVVLFNNGVHEIRDFFWDGIPYRGASWLREEPLDSVWVRVIFVPACGGLIVSVLNAARNAVSEASYSAKAALGSVLKALAACVTLGTGNSLGPEGPSVEIGSSIAKEIHSLLDKNPQTKLSLLAAGSAAGISSGFNAAVAGCFFAVESVLWPSSPADSSVSLTNTTSMVILSAVIASVISEVGLGSEPAFKVPEYDFRSPGELPLYLLLGLLCGLVSLAFSKLTSYLLGVVDNLNKDVGIPKPVFPIVGGLTVGVIALAYPEILYWGFDNVDLLLESRPFVKGLSGDLLFQLVAVKIIATSLCRAFGLVGGYYAPSLFIGAATGMAYGKFISFAIAQSDPAIHLSILEVASPQAYGLVGMAAMLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGLSSWITSGQMKRKDVKGTKALEDGNRYTIQQPEESDNTTSLSSTEAPPYFNNLCEVESSLCIDDSSIRTKDLEKRIFVKEAMRTRYVTVMTSTLLTEAVTLMLTEKQSCAIIVDNDNLLLGLLTLTDIHEFSKFAKDKSLDSKVLLVSEICSSDGAKCKVPWTATPTMDILSAEMIMNKYDLSHVPVISERVKDCRGQPIGLLDRECISLTCRALATRESLDFDTVKAIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TVP4</accession>
    <name>A0A0D2TVP4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G025700</name>
        <name evidence="4" type="ORF">Gorai_008732</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0591730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TVP4"/>
    <dbReference type="STRING" id="29730.A0A0D2TVP4"/>
    <dbReference type="Gramene" id="KJB47425">
        <property type="protein sequence ID" value="KJB47425"/>
        <property type="gene ID" value="B456_008G025700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762827"/>
    <dbReference type="eggNOG" id="ENOG502S16H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEWAFQN"/>
    <dbReference type="OrthoDB" id="1839683at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34052">
        <property type="entry name" value="GLYCINE-RICH PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34052:SF1">
        <property type="entry name" value="OS06G0216700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715740" description="Phytocyanin domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="2">
        <location>
            <begin position="55"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB47425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0591730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="173" mass="20142" checksum="CDABD6B88A688C99" modified="2015-04-29" version="1">MRFTGSTRLVIMMVASLWGMSIANKDWGSGYNHTNWGWGWGWGPYHPPNQTQGPNKINVGGSENWHFGFNYTEWAFQNGPFYFNDTLVFKYDPPSNNTFPHSVYLLPNLWSFLTCDLRRAKMIASPTQGGGDGFHFVLNRWRPYYFACGERNGFHCKVGRMRFVVVPLFRWNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U661</accession>
    <name>A0A0D2U661_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G045200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U661"/>
    <dbReference type="Gramene" id="KJB64364">
        <property type="protein sequence ID" value="KJB64364"/>
        <property type="gene ID" value="B456_010G045200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SZWA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEKNTNM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34950">
        <property type="entry name" value="OS04G0457400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34950:SF8">
        <property type="entry name" value="TPX2 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB64364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="8965" checksum="01A2C3611823F18A" modified="2015-04-29" version="1">MATYGVGLAEAYVMRSLHKEKMKKMDKQQASKSEEEEEENNNKMVFDDEMKMPASCFSWVSKKTHFARVSDASGKPNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFR2</accession>
    <name>A0A0D2UFR2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pectate lyase</fullName>
            <ecNumber evidence="4 9">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G197200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFR2"/>
    <dbReference type="STRING" id="29730.A0A0D2UFR2"/>
    <dbReference type="Gramene" id="KJB67544">
        <property type="protein sequence ID" value="KJB67544"/>
        <property type="gene ID" value="B456_010G197200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QT22">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNTLNQD"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF74">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="47"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB67544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="32237" checksum="2167B2CCDC1D0DDB" modified="2015-04-29" version="1">MISNIGKDVVKYKVIDPSDDPLSPKLGTLRYGTTMIKGEVWITFKNSMTITLQRPLLLSSFTAIDGRGVDVHITGAGCLLVYQATDIIIHGLRIHHCKAQPPSTVIGPNAKVIPLGQMDGDAIRLVTARKVWIDHNTLNQDKVMLLGHDDGHLRDKNMKVTVIFNHFGPNCNQRIVRHGYAHEANNFYQGWEQYAIGGSMSPSIKSEANFFVAPNDVGNKEVTWRKGEKGLWKFYSVGDVFKNGASLNKQTGVGGAKPKYNQEQNFKVVDAGSVKKLTSESGVLRCSRSLIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGG7</accession>
    <name>A0A0D2UGG7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G175300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="916"/>
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            <begin position="917"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="999" mass="115067" checksum="BC2CA2706973DC13" modified="2015-04-29" version="1">MDRSWMNLSRVSDGYRNGVQTFLNFAFQYASQENMIICPCKKCVNINWHYREVVYEHLIVDGFVRGYKQWLFHGECPLSTSSSRMDVSYDSTTYHQSDRGDDMEGMLRDAFNMHNHGVQSFPADFVAFDDCNIGRNAFTEPRSSVRHEEPNEEVTKFYALLNDMNDELYEGSKYSKMSFCVRLFQLKCLGGWTGNSLTMLLEFLREMFPFAKIPQSCKDMKKLIKDLGLGYNKIHSCPNDCMLYWGDRRNQHCCHVCGHSRWISQNEKGGNDDENDAQSRKKPVKILRYFPLIPRLQRLFMSSKTAESMMWHHDGRTDDELLRHPADFLAWKSFANKFPGFASDPRSVRLGLASDGFNPFKIMSTAYSTWPVVLVPYNLPPWICVKQSSLILSMIIPGEKGPGNDIDIYLQPLIGELKQLWAGVETYDVLRKENFNLRAALMWTVNDFPAYANLSGWSTKGRYACPCCAAQTCSQWLYNGKKFSYMGHRRWLPENHRFRFQSSVFDGTEEFREAPSQTSGSEILGMLEDMNFIYGKMNQPPNTQRNKRSNDEADDDSDEEDDPNEADLWKKRSIFFELPYWEHHLLRHNLDVMHIEKNVCENIVGTILNVDGKSKDNLQSRLDLVQMGIRPDLHPNPLPNGKYRLPPSIFSMSKTEKEVFCTVLKDMKVPDAYASNISRCVSVKDRRLYSLKSHDYHILMQDLLPVAVRCCMSKKVTSCIIELSNIMKAICGKILDVQELQKVQDRAALTLCNMEKIFPPSFFTIMVHLIIHLPHETILGGPVFYRWMYPIESGKNVNDEVKWLSQGPNRVVKRYSAFLINGFRFHTKYRERLRRTQNCGIVVNSAITSYASARDNNPVEGNVEYFGHLTDIIELDYYGKWKVVLFRGDWADVNTARGIKQDQFDKMPRRKILRGSITRNEPNSTETNSTEQQTAIGSSNVPITSEDPTEVQTENGGTRRGRGRTLLRELYELDPVERVKVGRNSFGQPVGSEARLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJZ7</accession>
    <name>A0A0D2UJZ7_GOSRA</name>
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            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
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    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214:SF8">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214">
        <property type="entry name" value="ZINC FINGER, RING-CH-TYPE"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB68371.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="293" mass="32013" checksum="5386E3FEB57811B6" modified="2015-04-29" version="1">MDQEERCDRVEISKNSSQIDSNSINGAVFVKNSDENAGLRLQNDEFGSCKHVEISYVSGIGSVSSQNGQSIENSSSLVEGNINNDVVSSEGSIETIKTRVVDERLSRVGDECVVETIVVVESNGVLAEMPVGKVAERDDSCVIDINGSSGGTRWFKDSYDGERVCRICHLNSEQLLESNDSISTTAAVTDLILLGCGCKDELGIAHGHCAEAWFKLKGNRMCEICGQTAKNITGVRDNRFNEDWHEQGSTSGVDFISSDQGTGCWRGQPLCNFLMACLVISFVLPWFFHVNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR05</accession>
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        <name evidence="11" type="ORF">B456_011G086000</name>
        <name evidence="12" type="ORF">Gorai_005601</name>
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        <name type="scientific">Gossypium raimondii</name>
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    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0599380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR05"/>
    <dbReference type="STRING" id="29730.A0A0D2UR05"/>
    <dbReference type="Gramene" id="KJB70666">
        <property type="protein sequence ID" value="KJB70666"/>
        <property type="gene ID" value="B456_011G086000"/>
    </dbReference>
    <dbReference type="OMA" id="VWVGFTK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010547">
        <property type="entry name" value="TOM20_imprt_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32409">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32409:SF3">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06552">
        <property type="entry name" value="TOM20_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB70666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0599380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="76" mass="8051" checksum="EA58017E1394D5A7" modified="2015-04-29" version="1" fragment="single">APELHREILKHGLDQQIVGVGPSAATSSSSAKDAKKGKKSYDLKYDIVGWIVLAIGIVVWVGFTKSQMPPPPPPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URV5</accession>
    <name>A0A0D2URV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G121400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URV5"/>
    <dbReference type="STRING" id="29730.A0A0D2URV5"/>
    <dbReference type="Gramene" id="KJB71364">
        <property type="protein sequence ID" value="KJB71364"/>
        <property type="gene ID" value="B456_011G121400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775784"/>
    <dbReference type="eggNOG" id="ENOG502S1DP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HERRQYM"/>
    <dbReference type="OrthoDB" id="783357at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008889">
        <property type="entry name" value="VQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039611">
        <property type="entry name" value="VQ_4/11/13/19/31/33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33402">
        <property type="entry name" value="VQ MOTIF-CONTAINING PROTEIN 11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33402:SF22">
        <property type="entry name" value="VQ MOTIF-CONTAINING PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05678">
        <property type="entry name" value="VQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VQ" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB71364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="170" mass="18803" checksum="27FFDBB5B02C7BE5" modified="2015-04-29" version="1">MEKPASQTATPCKPLTTFVQTDSNTFQEIVQRLTGPSESDPAQGAATKGPGLKRPISKLHERRQSMRPKLEIVKPPLSFKPATSPSRSGSSNLLASPVGTPSTIFSKLTFLEDEYIEELTKTELNTVEEEKAIKERRFYLHPSPRSRAGKTDPELLVLFPLTSPRTNNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXJ1</accession>
    <name>A0A0D2UXJ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TFIIF beta subunit HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G240900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXJ1"/>
    <dbReference type="STRING" id="29730.A0A0D2UXJ1"/>
    <dbReference type="Gramene" id="KJB73624">
        <property type="protein sequence ID" value="KJB73624"/>
        <property type="gene ID" value="B456_011G240900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778089"/>
    <dbReference type="eggNOG" id="KOG2905">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHNQNLE"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF2">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIF, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="7">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB73624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="262" mass="29689" checksum="FBE1EE4D80276C77" modified="2015-04-29" version="1">MENKDNYLETSKAERSVWLMKCPGLVSRSLKAPQLSSSSSSSSASSSQAVAKVILSIDPRVSSDDNDSSSPQFTMELVGTETGDVPKRYSMDMTKDFVPMSVFSETSQGKLAVEGKILNKFDMRPHDENIENYGKLCRERTTKSMNKSRQIQVIDNDNGTHMRPMPGMIIAAVFNEKKKAPAKTSDTKRTRRDRGEMEDIMFKLFERQSNWTLRQLIQETDQPEQFLKDILKDLCIYNNKGTNQGTYELKPEYKKATDGTNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V051</accession>
    <name>A0A0D2V051_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UMP-CMP kinase</fullName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate/cytidine monophosphate kinase</fullName>
            <shortName evidence="9">UMP/CMP kinase</shortName>
            <shortName evidence="9">UMP/CMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G006800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>CMP + ATP = CDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>dCMP + ATP = dCDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V051"/>
    <dbReference type="STRING" id="29730.A0A0D2V051"/>
    <dbReference type="Gramene" id="KJB74779">
        <property type="protein sequence ID" value="KJB74779"/>
        <property type="gene ID" value="B456_012G006800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIEEHMR"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="30"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>CMP</name>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB74779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="220" mass="24663" checksum="015A4367F454A6BC" modified="2015-04-29" version="1">MGTANDSSKDISVRLAEKNPKVVFVLGGPGSGKGTQCEKIVQHFGYTHLSAGDLLRAEKNSGSENGIMIQNMMNEGKIVPSEVTIKLLQKAMLESGNDKFLIDGFPRNEENRAAFEAVTKIEPEFVLYFNCSEKEMERRILNRNQGREDDNIETIRKRFKVFLESSLPVIEYYKGKGKVREIDAAKPVEEVFEEVKDIFTPEVRKVVGGRGWGRGCCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V0T5</accession>
    <name>A0A0D2V0T5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycine-rich cell wall structural protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G025900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V0T5"/>
    <dbReference type="Gramene" id="KJB75131">
        <property type="protein sequence ID" value="KJB75131"/>
        <property type="gene ID" value="B456_012G025900"/>
    </dbReference>
    <dbReference type="OMA" id="WNEEPNG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253131" description="Glycine-rich cell wall structural protein 1" evidence="2">
        <location>
            <begin position="23"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB75131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="13048" checksum="3873084FEBDD4E55" modified="2015-04-29" version="1">MGSCRVIGALFLVLLLVDLAFAARSFKAVGKGGGAGGGGGGGSGGGGANGLGSGSGYGSGYGSGSGSGYGSGAYGSGGGGGGGGGGGGGGGSSGSGGGNGGGSGYGSGSGYGSGGGRGGGGGGGGGGGGGGGGGNGSGYGSGSGYGSGSGYGSSGDDDYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V0Y9</accession>
    <name>A0A0D2V0Y9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Indole-3-acetic acid-amido synthetase GH3.17-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G029900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IAA-amido conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V0Y9"/>
    <dbReference type="Gramene" id="KJB75191">
        <property type="protein sequence ID" value="KJB75191"/>
        <property type="gene ID" value="B456_012G029900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPMW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LVECCEL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055378">
        <property type="entry name" value="GH3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055377">
        <property type="entry name" value="GH3_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="GH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901:SF57">
        <property type="entry name" value="INDOLE-3-ACETIC ACID-AMIDO SYNTHETASE GH3.17-LIKE ISOFORM X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23572">
        <property type="entry name" value="GH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23571">
        <property type="entry name" value="GH3_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH3 middle" evidence="3">
        <location>
            <begin position="352"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="GH3 C-terminal" evidence="4">
        <location>
            <begin position="449"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB75191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66580" checksum="F700802D198DE5C7" modified="2015-04-29" version="1">MPADMCGSRLMAANGYEGELKMIEELTTNAEQIQEEVLGEILSRNAGTEYLRGFLHGQTEKQLFKKNVPIVTYEDLKPYIDRIANGETSDILLAEPITGFFLSSGTSGGQPKLMPVTAQVVNKWELFRGLYESPAMKHFGDINQAGKGLELMFARPEIETPSGLKAASVSTSIYNECNFRANLPKLYTSPVETIFCPDPNQGLYCQLLFGLIQRDEVVKVGSVFASTVLRGIKFLENHWQELCYDIKTGRLSDWITDSGCRNAASLVMKPNPEQADLIETICNCKSWEGIIRKLWPKARYIWCICTGIMRQYTTELEFYCRGLPLVSALYACSEAICGINLEPLRKPCDVSYTFLPNMAYFEFLPVKNEGDGSIEMKSNNEDTELVDLVNVKAGQCYELVVTTCAGLYRYKVGDVLMVSGFYNNAPQFQFVERKNVILSVDQEKTSETDLFKAVTEAKALLDPLGFILTEYTSYVDTSSAPGHYVLFWEIKGKEGKHCKELDPKIMVECCSRMEESLHYTYKIYRERNIIAALEIRVVKQESFEALMDYYVSKGTSMSQYKKPSCIKSEEALNILDSRVIGKYFSPKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4Q2</accession>
    <name>A0A0D2V4Q2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G104800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V4Q2"/>
    <dbReference type="STRING" id="29730.A0A0D2V4Q2"/>
    <dbReference type="Gramene" id="KJB76744">
        <property type="protein sequence ID" value="KJB76744"/>
        <property type="gene ID" value="B456_012G104800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780944"/>
    <dbReference type="eggNOG" id="ENOG502R1XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYGSHAL"/>
    <dbReference type="OrthoDB" id="652816at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000006">
        <property type="entry name" value="WRKY transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF42">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 49-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="108"/>
            <end position="173"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
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            <begin position="180"/>
            <end position="209"/>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00022737"/>
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            <dbReference type="ARBA" id="ARBA00023125"/>
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            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB76744.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4U0</accession>
    <name>A0A0D2V4U0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone reductase (non-electrogenic)</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_012G131700</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="18">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
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            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
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        </reaction>
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    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
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            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NADH dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_012G131700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779991"/>
    <dbReference type="eggNOG" id="KOG2495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
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            <begin position="39"/>
            <end position="582"/>
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    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="582" mass="65366" checksum="7211402D7CAF7C5C" modified="2015-04-29" version="1">MTILSFFTRASRAFNGYPASAKLLLLCTLSLSGGGVVAYSEAQVDASKTSVQVNEKDCKKKRVVVLGTGWAGISFLKDLDVSAYDVQVVSPRNYFAFTPLLPSVTCGTVEARSIVEPVRNIIKKRNGEIQFWEAECMKIDAANKKLLCRYTVENNLVGNDEFSLEYDYLVLAVGAQVNTFNTPGVLENCHFLKEVEDAQKIRRTVIDCFEKAVLPGLSEEERRINLHFVIVGGGPTGVEFAAELHDFVQEDLVNLYPSVKDMVKITVIQSGDHILNMFDERISSFAEQKFRRDGIEVQTGSRVISVSDKEITMKLKAKGEICSVPHGLVVWSTGVETRPFVKDFMGQIGQANRRVLATDEWLRVKGCEDVYALGDCATINQRKVMEDIAAIFKAADKDNSGFLTVEEFKDVIDDILERYPQVEHYLKSKHLRDVTDLMKDSEGNDIDEVDIEGFKLALCQADSQVKNLPATAQVAAQQGAYLSKCFNRKSKWKDNPEGPRRFRGSGRHQFHPFQYKHLGQFAPLGGEQAAAELPGDWVSVGRSTQWLWYSVYASKQVSWRTRVLVVSDWTRRFIFGRDSSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5K8</accession>
    <name>A0A0D2V5K8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G149600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5K8"/>
    <dbReference type="STRING" id="29730.A0A0D2V5K8"/>
    <dbReference type="Gramene" id="KJB77661">
        <property type="protein sequence ID" value="KJB77661"/>
        <property type="gene ID" value="B456_012G149600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCELEPD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000047">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000071">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058980">
        <property type="entry name" value="Glyco_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF45">
        <property type="entry name" value="SCOPOLETIN GLUCOSYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26168">
        <property type="entry name" value="Glyco_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB77661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="53927" checksum="09E54D35FAA59E1B" modified="2015-04-29" version="1">MTQQLHIFFFPFMAHGHTIPFIDLAILFATKGVKSTIIATPSNAPHIKKVTHKANKLGYQIDTLVIKFPAVEAGLPDGCDDTDKVPSPDMMPKFFLAVEMLKQPLSDLLKQHCPHCLVADMFFPWTTEVAAMFKIPRIVFHGTCVFSLSAMEHVRLYQPHKSKETFTIPNFPGDDIKMTTAELQDYVKQETWRTKLFNDSKETESECFGVIVNSFYELESVYADHYTDFLGRRAWHVGPISLSTKGVINKAERGKQYSSIEEHECLKWLQSKDRNSVVYICFGSTTNFVDSQLMEIAKGLEASGQQFVWVVRKEKESNDEKGKENWLLEFEKRMEGKGLVIRGWAPQVLILENEAIGGFVTHCGWNSILESVTAGVPVITWPVAAEQFYNEKLSVEVLKIGVGVGARKWKRLVGDFVKSEAIEKAVKEIMVGEKAMEMRNRAKRFADMAKKAVEDGGSSESHLNALIGELSSTAVKTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V811</accession>
    <name>A0A0D2V811_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G093900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V811"/>
    <dbReference type="STRING" id="29730.A0A0D2V811"/>
    <dbReference type="Gramene" id="KJB65415">
        <property type="protein sequence ID" value="KJB65415"/>
        <property type="gene ID" value="B456_010G093900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QU93">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="4">
        <location>
            <begin position="114"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="4">
        <location>
            <begin position="186"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB65415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="28615" checksum="01D5B5319F3B5FDF" modified="2015-04-29" version="1">MSKISSPEIVNCGIKSSGPNSGSLTFSVRVQRRIPDFLQSVSLKYVKLGYHYLINRGIYLATIPVLVLVFSAEVGSLSREELRKKLSEDACYDLATVLSFFTVFCIHHFCLLYVTKEQFIEMARASGKFDEASLQFQKRIVKSSGVGDETYLPKAVMSDENSATMKEGRLEASTVMFGALDELFENYNLGGMGCSAGLIAVDLARDMLQANPNNYAVVVNTEMVGYNWYPGRDRSMLVPNCFFQDGMLRSPFVELPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V9Y6</accession>
    <name>A0A0D2V9Y6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G135000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V9Y6"/>
    <dbReference type="STRING" id="29730.A0A0D2V9Y6"/>
    <dbReference type="Gramene" id="KJB66315">
        <property type="protein sequence ID" value="KJB66315"/>
        <property type="gene ID" value="B456_010G135000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774022"/>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IKPRYWV"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000015">
        <property type="entry name" value="Mitochondrial transcription termination factor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF3">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION TERMINATION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB66315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="588" mass="66949" checksum="FA23BF05EDF67581" modified="2015-04-29" version="1">MSTKSFSIHWNLKSQFPNTCFLPFARRCSLNAFPLSFFHCPRIHSPKPYLPQPPLVQSNPYNQTPHDLTQARESISEYLQELGLSLEDSISISSNSPKYVQMLVDGVKELEEWNAWNDSNGEGDSLGFKEMIIYMAKEKGDNGKVAFLESVGLPLSSAMSVARYLSSESLPSIIRKVKYMKENIFSAGDDKGGLSGKNARRMMMHLSISSDEDVQQTLSFFEKIEARRGGLEILGLVDATFRFLLESFPRLLLLPVESHLEPMVEFLENIGVPRRSMGNVFLLFPPILFYKIQGIKSKFLTFEKVGAAYKDIGKMLLKYPWILSTSIQENYEQILLFFEEEKIPKTSVDRAIRSWPHLLGCSTSKLKLMVDQFGELGIRNKKFGRVIAKSPQLLLKKPQEFLQVVLFFEELGLAQETVGKLVSRCPEVFAANIDTTLKKKVELLAEFGISNDHLPRVIKKYPEVLVSDVNKTLLPRINYLMEMGLSRREIALMIRRFPPLLGYSIKEVLKPKLNFLLNTIGKPVKDVVGYPRYFSYSLEKKIKPRFWVLKGKNIECSLEVMLGKNDEEFAAEFMGVGRMLVSPSATFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA82</accession>
    <name>A0A0D2VA82_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G139400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VA82"/>
    <dbReference type="STRING" id="29730.A0A0D2VA82"/>
    <dbReference type="Gramene" id="KJB66415">
        <property type="protein sequence ID" value="KJB66415"/>
        <property type="gene ID" value="B456_010G139400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1072">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GGIMMEI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052439">
        <property type="entry name" value="F-box/Kelch-repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122">
        <property type="entry name" value="GALACTOSE OXIDASE/KELCH REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46122:SF6">
        <property type="entry name" value="OS04G0619300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB66415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="10600" checksum="7125B78EB6917F2F" modified="2015-04-29" version="1">MKCCDKVKKYDKVNNSWSVVKRLPVRADSSYGWGLAFKACGNSLLVIGAGGHGGHDDGVIVLHSWNPDEGNRDGQEWNVLAVKARAGTFVYNCAVMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCA6</accession>
    <name>A0A0D2VCA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">X8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G188600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VCA6"/>
    <dbReference type="STRING" id="29730.A0A0D2VCA6"/>
    <dbReference type="Gramene" id="KJB67395">
        <property type="protein sequence ID" value="KJB67395"/>
        <property type="gene ID" value="B456_010G188600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772940"/>
    <dbReference type="eggNOG" id="ENOG502S140">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWCIADQ"/>
    <dbReference type="OrthoDB" id="2019109at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1040:FF:000001">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044788">
        <property type="entry name" value="X8_dom_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044">
        <property type="entry name" value="BETA-1,3 GLUCANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31044:SF55">
        <property type="entry name" value="CARBOHYDRATE-BINDING X8 DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269177" description="X8 domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="10">
        <location>
            <begin position="29"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB67395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="118" mass="13107" checksum="5F2966D4F9890DAD" modified="2015-04-29" version="1">MSSALHRILLVLCLVSLLLQMTAGGGFREWCIADEQTPDEELLKALDWACGKGGADCSKIQVNQPCYHPNTIKDHASYAFNNYYQKFKNKGATCYFNSAAIITDLDPSHNSCKFETVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHA0</accession>
    <name>A0A0D2VHA0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-galactosidase</fullName>
            <ecNumber evidence="4">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_013G222800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHA0"/>
    <dbReference type="Gramene" id="KJB82976">
        <property type="protein sequence ID" value="KJB82976"/>
        <property type="gene ID" value="B456_013G222800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VMGQLNN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000098">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266006" description="beta-galactosidase" evidence="12">
        <location>
            <begin position="23"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="13">
        <location>
            <begin position="31"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="14">
        <location>
            <begin position="587"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB82976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="794" mass="89910" checksum="AEF9107E12B3B380" modified="2015-04-29" version="1" fragment="single">MNIFNLLFTAFIFSFILFHSNALNVTHDSRSIIIDGNHRIVLSGSIHYPRSTAQMWPDLIRKAKEGGLDAVETYVFWNAHEPTRRQYDFSGNLDLIRFLKTIQDQGLYAILRLGPYTCAEWNYGGFPVWLHNMPGVSLRTKNDVFMNEMKNFTTLIVDMVKKEKLFASQGGNIILAQVENEYGNVMEPYGDEGKSYINWCAQMADSLDIGVPWIMCQQAAPPKPMLETCNGWYCDEYKPKDPNTPKLWTENWTGWFKSWGGADPFRTAEDLAYSVARFFQKGGTLQNYYMYHGGTNFGRTSGGPYITTTYDYNAPLDEYGILNQPKWGHLKQLHDVLHSIEYILTNGDVKNEKLSNLVMKLNKAEDEPSSLKWMWRPELIESTSVQGRGDVSVNKIVDQKDMANDASDYLWYMTSINVAKDDPMLNGTVTLRVNDTGHVLHAFFNGEYIGNYELCFIYIILNSKYIYLSIYVFVFVGSQWSKYGNNNVTYVFERNINLSLGKNLISLLSVTVGFKNYGPMFDLVGAGITSPIELVLNKNVVKDLSSNKWTYKVGLNGISNKFFDIDCASKSSSKWVSDPIPIYRNFTWYKTTFKAPLGNKPVVVDLLGLGKGMAWVNGHSLGRYWPSYIADKQLCKTETCDYRGRYSDSKCVSKYHVPRSFLKDSENTLVLFEEFGGNPSGVQFQTVEIGSVCINTHEGKEVELSCQDRPISKIKFASFGSPQDSIEVQMNKLFSKGVSTVLANSTIDAFDDHEEIEARGTKAVFPTTLGILGDLSSFTMDLKIQRAKDIPLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIF8</accession>
    <name>A0A0D2VIF8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_013G215200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">ATP-dependent RNA helicase involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. In addition to ssRNA and dsRNA, binds dsDNA, but not ssDNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with ALY2 and MOS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIF8"/>
    <dbReference type="STRING" id="29730.A0A0D2VIF8"/>
    <dbReference type="Gramene" id="KJB82814">
        <property type="protein sequence ID" value="KJB82814"/>
        <property type="gene ID" value="B456_013G215200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782415"/>
    <dbReference type="eggNOG" id="KOG0329">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSKNWQQ"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000168">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase 56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="78"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="279"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00065936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB82814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="428" mass="48443" checksum="AD4707C7CB5EF04D" modified="2015-04-29" version="1">MGETRDNDVYEEDLLDYDEEEEKAPDSVTAKVNGEAGKKGYVGIHSSGFRDFLLKPELLRAIVDSGFEHPSEVQHECIPQAILGMDVICQAKSGMGKTAVFVLSSLQQIEPSPGQVIALVLCHTRELAYQICHEFERFSTYLPDIKVAVFYGGVNIKVHKDLLKNECPHIVVGTPGRILALTRDKDLSLKNVRHFILDECDKMLESLDMRRDVQEIFKMTPHDKQVMMFSATLSKEIRPVCKKFMQDPMEIYVDDEAKLTLHGLVQHYIKLSELEKNRKLNDLLDALDFNQVVIFVKSVSRAAELNKLLVECNFPSICIHSGMSQEERLTRYKGFKEGHKRILVATDLVGRGIDIERVNIVINYDMPDSADTYLHRVGRAGRFGTKGLAITFVSSASDSDVLNQVQERFEVDIKELPEQIDTSTYMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJH3</accession>
    <name>A0A0D2VJH3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-coenzyme A thioesterase 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Hotdog-fold thioesterase superfamily member 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Thioesterase superfamily member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_011G073600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates. Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro). May play a role in controlling adaptive thermogenesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a fatty acyl-CoA + H2O = a fatty acid + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16781"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:16782"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer. Interacts with PCTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cytoskeleton</location>
            <location evidence="3">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJH3"/>
    <dbReference type="STRING" id="29730.A0A0D2VJH3"/>
    <dbReference type="Gramene" id="KJB70445">
        <property type="protein sequence ID" value="KJB70445"/>
        <property type="gene ID" value="B456_011G073600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778588"/>
    <dbReference type="eggNOG" id="KOG3328">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NICGSCI"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000021">
        <property type="entry name" value="Acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF52">
        <property type="entry name" value="SUPERFAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="19">
        <location>
            <begin position="71"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00064709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00081533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00083956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB70445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="171" mass="18721" checksum="98183D9AA5F5E76F" modified="2015-04-29" version="1">MKADTSKEEAQSMTMMHLQLQRSLKWLDDVTHGIIGYELESRSLAGLQVIEARTGFLRCNFIVPLLASDINGNWHVGAIATIIDNVGGAAIYSTGHHLKVTVNFNITYYSTAKIQDEAEIEAKVKGNKGKLTSMAVEVRNKSSGGQLIASATQWTAANDYRSPQPQSRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VNX8</accession>
    <name>A0A0D2VNX8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G187500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="GALACTOSE OXIDASE_KELCH REPEAT SUPERFAMILY PROTEIN"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LXM2</accession>
    <name>A0A0D2LXM2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="790"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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        </location>
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        </location>
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        </location>
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            <begin position="509"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="537"/>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="842" mass="95351" checksum="D7B3E5FFEDCA6E91" modified="2015-04-29" version="1">MAIAGLHNVSVLENSFLRESQSQASRRRGNGSTRPSSLLQMWRELEDEHVVSHAQERTNERMLQRRSNDLPMTDLSDSRHSEHSGVSEDVSVSVSENEFVQWLPDQFGLQNGSEDSSNFDCEHSSDLGEVERERVRQIFQEWMNSGGRGCTSNVSGRNNSSRAQWLGETEQERVRIIREWVQMNSQQRGSLTDSREEQAADAGGQIERLLDGLVVNQNAGRTEHVHRGIRKLCGRQALLDMLKKAERERQTELQRLLEHRAVSNFAHRNRIQSLLRGRFLRNDRMVEGDRSTSIAASELGLLRQKQTVSGLREGFLSRLDNSCSGPASSNRSDRSSSADSDGNRSEENRVNNTHDAIGGLNDRSECENEETDNGRCMIGTTDLEVETEVSQQATSACLEDQQEQVSESVFSIWQGSASAESNESRYDIGQVFDGPRQESLADESSLETLQNEAGEQSNLQESGEASYERSFQDGERSRTYWLTNVVQNVERVPVDHIDGQEPASQGEQWQEEDQETEDADWQEASLDHNELMDDRNEEASDMNHEDGESENGGYDDMQEAPDAQREDGGLHDTRQNWFEGSYNLQAATIGRTDTFYLPDDDNVHNTELRELLSRRSVSTLLRSGFRESLDQLIQSYVERQNHASVDWDLNEAAPTPESLEQDIEQQSRDQNEGQSSPIAPSSPRMPSTQPLWDQDSHHYNWQPHDGHQRFGIEWEIINDLRVDMTRLQQRMNNMQRMLEACMDMQLELQRSIRQEVSAALNRSAGSQGMIDDDLPKDASSNWDNVRKGICCICCESNIDSLLYRCGHMCTCLNCATELAHGGGKCPMCHAPVVEVIRAYSIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M000</accession>
    <name>A0A0D2M000_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G178000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as an E3 ubiquitin ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M000"/>
    <dbReference type="Gramene" id="KJB09962">
        <property type="protein sequence ID" value="KJB09962"/>
        <property type="gene ID" value="B456_001G178000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000082">
        <property type="entry name" value="RING-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058678">
        <property type="entry name" value="ARM_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057314">
        <property type="entry name" value="PUB2-4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF278">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25598">
        <property type="entry name" value="ARM_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25240">
        <property type="entry name" value="PUB2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="9">
        <location>
            <begin position="251"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="546"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="587"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="628"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="8">
        <location>
            <begin position="669"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB09962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="793" mass="87510" checksum="C40E344548E4BC2E" modified="2015-04-29" version="1">MFLSVYDLSARVETGQMDTTSVRCLVNSISRFIHLVSCQTIKVAPVEKDYRNMVIVLKLLKPLLDDVIECEIPSDDILYKECEELDMLVNEAREFTENWCPKMSKIHRVLQSEPFLTKMQSSSLQICHILYRLLQSTPSSSSITSVQHCMREIKSMEQERPSENIGQTLRSKKDDAIPCTEHLINVMKSLNLMSNQELLKETLALERERTDAQVNNAKGKIDQINQIMDLISHIRDYMLKIEHFEPTSGILIPPDFLCPLSLELMLDPVFVASGQTYDRASIQKWLDSGLTICPKTRQTLAHKNLIPNYTVKAMVTSWCEENNLQLSNAKLVSISSPSNHISSQDLTYSYSSSSASRSSLEVGNGLEKQMIDSSSRFSGECNRCQSRETGKYDHQSPDQSYVHNRTESASSAIYSVDYAPTPASNDLSMRSKKNEINELAEISSKSLGNFPSTKEYGLSHSIMGKQLQVSGTKIEDAVNGNHNYNRAYSSAFSRPGCDDLITSSLVKKLVDNLQSLSNEVQTTAAAELRLLAKHNMDNRIIIGRCGAIAPLLSLFYSEVKITQEHAVTALLNLSINEDNKAVIAKSGAIEPLIHVLKSGNDGAKENAAAALFSLSVLEECKARIGRSGAVKALVNLLSSGTLRGKKDAVTALFNLSIFHENKARIVQAGAVKYLVELMDPDSGMVDKAVALLSNLSTIGEGRLAIVRESGIPILVEVIESGSRRGKENAASVLLQLCLNSPKFCTLVLQEGAVPPLVALSQSGTPRAKEKAQQLLGHFRNQREGSMGKARHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M233</accession>
    <name>A0A0D2M233_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein XRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G233300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M233"/>
    <dbReference type="STRING" id="29730.A0A0D2M233"/>
    <dbReference type="Gramene" id="KJB10946">
        <property type="protein sequence ID" value="KJB10946"/>
        <property type="gene ID" value="B456_001G233300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10947">
        <property type="protein sequence ID" value="KJB10947"/>
        <property type="gene ID" value="B456_001G233300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10948">
        <property type="protein sequence ID" value="KJB10948"/>
        <property type="gene ID" value="B456_001G233300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804682"/>
    <dbReference type="eggNOG" id="ENOG502QTT2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSQEYDL"/>
    <dbReference type="OrthoDB" id="1913204at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007143">
        <property type="term" value="P:female meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007140">
        <property type="term" value="P:male meiotic nuclear division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039933">
        <property type="entry name" value="XRI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33385">
        <property type="entry name" value="PROTEIN XRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33385:SF4">
        <property type="entry name" value="PROTEIN XRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32959" checksum="C296FAA6DBB7B177" modified="2015-04-29" version="1">MDYNYDQEPWNWHGDQKNNDFGASEGAWTQVTLNEEDLSYMFVEATPVKECGDLSYHVTQNDDISKESEEKRETASQVKRRRMLQFDTHAVDSSLICEEMPSAFLKSRERDDMIEEILPDASEWVAGLSEDASASSYDGLDQSCEGWLAEYFNDPELLLSSDDMNLTGASNVQIDTSELCNAQPESGADAVQKQATRTLGNVVLKGRKSFIRMPPKVASSVAYPFAFIKPCGFHGDVTLKDINQRIRTPPPSKSKQSNEDLADAFPTSAFSGKPVVGKTKIRTEGGKGTITIMRTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M554</accession>
    <name>A0A0D2M554_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G008700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:25017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57836"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="EC" id="3.1.3.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PTEN phosphatase protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M554"/>
    <dbReference type="STRING" id="29730.A0A0D2M554"/>
    <dbReference type="Gramene" id="KJB12259">
        <property type="protein sequence ID" value="KJB12259"/>
        <property type="gene ID" value="B456_002G008700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB12261">
        <property type="protein sequence ID" value="KJB12261"/>
        <property type="gene ID" value="B456_002G008700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB12262">
        <property type="protein sequence ID" value="KJB12262"/>
        <property type="gene ID" value="B456_002G008700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773283"/>
    <dbReference type="eggNOG" id="KOG2283">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PCPGFQV"/>
    <dbReference type="OrthoDB" id="266663at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14509">
        <property type="entry name" value="PTP_PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000053">
        <property type="entry name" value="Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055183">
        <property type="entry name" value="PTEN2A/B_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045101">
        <property type="entry name" value="PTP_PTEN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014020">
        <property type="entry name" value="Tensin_C2-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF96">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND PROTEIN-TYROSINE-PHOSPHATASE PTEN2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22918">
        <property type="entry name" value="PTEN2_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01326">
        <property type="entry name" value="PTEN_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51182">
        <property type="entry name" value="C2_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="228"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="C2 tensin-type" evidence="10">
        <location>
            <begin position="321"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62123" checksum="895BF96B24E3C3D6" modified="2015-04-29" version="1">MDNGPADSSSSPAAEASDVQLPAATDLGQQNLTHDSPSKLSSWAKNLKIPQPFAASQEDSQTETAGKSPLARFTSGIGLRSSPKSPPANDSNEGNSPTTQPGFFGTITNGIVNTSKNAVKAVQVKARHVVSQNKRRFQEGGFDLDMTYITENIIAMGFPAGDMSSGFFGYVEGFYRNHMEEVIRFFETYHKDKYKVYNLCSERLYDASLFEGKVASFPFDDHNCPPIRLIISFCQSAYSWLKEDIENVVVVHCKAGMARTGLMISSLLLYLKFFPTAEESIDYYNQKRCVDGKGLVLPSQIRYVKYFERTLIYFNGENPPGRRCILRGFRLHHCPYWIRPSITISDHNGVLFSTKKHPRTKDLSPEDFWFSAPKKGVMVFALPGESGLTELAGDFKVHFNDRQGDFYCWLNTTMIENRKILSTGDLDGFDKRKLPSPGFQVEIVLVDYSGTAPTKSQTETPTNKQDESSGTSESADGATSKSKTTNSDQVASLVKSTEKVSIGSTDTQHTHAINEPRKDTVQQAADAADARVSISSSESQFKAMAADASVFSFGDEEDFDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M5V8</accession>
    <name>A0A0D2M5V8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_002G023400</name>
        <name evidence="23" type="ORF">Gorai_022147</name>
    </gene>
    <organism evidence="22 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="23 25" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">8</strain>
            <tissue evidence="23">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="23">8</strain>
            <tissue evidence="23">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Plastid</location>
            <location evidence="18">Chloroplast thylakoid membrane</location>
            <topology evidence="18">Single-pass membrane protein</topology>
            <orientation evidence="18">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0579904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M5V8"/>
    <dbReference type="SMR" id="A0A0D2M5V8"/>
    <dbReference type="STRING" id="29730.A0A0D2M5V8"/>
    <dbReference type="MEROPS" id="M41.025"/>
    <dbReference type="Gramene" id="KJB12537">
        <property type="protein sequence ID" value="KJB12537"/>
        <property type="gene ID" value="B456_002G023400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010304">
        <property type="term" value="P:PSII associated light-harvesting complex II catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000035">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 6 chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.210:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF139">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="16" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033219931" description="AAA+ ATPase domain-containing protein" evidence="20">
        <location>
            <begin position="16"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="272"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00060455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="MBA0579904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="702" mass="75521" checksum="CADE7288B9AF22E6" modified="2015-04-29" version="1">MIYLFIMQMAASSACLLGNGLSTHRTKSKLSKDFYGRNIVFTPAISSLGRKSNAVLVKASLKLKQHEGRRGFLKSLLGTAGIGVPALLGNGKAYADEQGVSSSRMSYSRFLEYLDKDRVKKVDLFENGTIAIVEAVSPELGNRVQRVRVQLPGLSQELLQKFREKNIDFAAHNAQEDSGSLLFNLIGNLAFPLILIGGLFLLSRRSSGGMGGPGGPGFPLAFGQSKAKFQMEPNTGVTFDDVAGVDEAKQDFMEVVEFLKKPERFTAVGARIPKGVLLIGPPGTGKTLLAKAIAGEAGVPFFSISGSEFVEMFVGVGASRVRDLFKKAKENAPCIVFVDEIDAVGRQRGTGIGGGNDEREQTLNQLLTEMDGFEGNTGIIVIAATNRADILDSALLRPGRFDRQVTVDVPDIRGRTEILKVHGSNKKFETDVSFDVIAMRTPGFSGADLANLLNEAAILAGRRGKTAISSKEIDDSIDRIVAGMEGTVMTDGKSKSLVAYHEVGHAICGTLTPGHDPVQKVTLIPRGQARGLTWFIPSDDPTLISKQQLFARIVGGLGGRAAEEIIFGEPEVTTGAAGDLQQITGLAKQMVVTFGMSEIGPWSLMDSSAQSADVIMRMMARNSMSEKLAEDIDTAVKRLSDSAYEIALQHIRNNREAIDKIVEVLIEKETMSGDEFRAILSEFVEIPAENQVPPSVPTPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MCP0</accession>
    <name>A0A0D2MCP0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_002G181600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MCP0"/>
    <dbReference type="Gramene" id="KJB15502">
        <property type="protein sequence ID" value="KJB15502"/>
        <property type="gene ID" value="B456_002G181600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785739"/>
    <dbReference type="eggNOG" id="ENOG502RZAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFHTRSH"/>
    <dbReference type="OrthoDB" id="1915472at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="65"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0581188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OS08G0163500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        <location>
            <begin position="349"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0581188.1"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="49972" checksum="87E20F62637FCEAB" modified="2015-04-29" version="1">MDPCPFVRILVGNLALRFPLSTKPSLSRIHPSTSPCYCKIKLKNFPHQVGSIPLIHANTQNPESCNFSLQKSLAACFSLSKSQVDRIISKGGSSYKLSIEVYADPDGSTCGLASGKLLGRVTVPLDLRGAESRSSVAHNGWIDIGRNKSNKNGSSAQMFLTVRTEPDPRFVFQFGGEPECSPQVFQVQGSVKQAVFTCKFGFRSSSDRNLGSRTSLPESNTSRNWLPSLKTDKDQSAKERKGWSITVHDLSGSPVAMASMVTPFVPSPGSDRVSRSNPGAWSILRPECGTWKPWGRLEAWREPGFTDALGYRFDLFHDDIVATGTTTTVASSTLSTKLGGKFTMDMTTNITTPSVSPQSSCDLGSGSRPGSRPGSGSGSDFGFGLPLSPQSMYRGGFVMSSTVEGVGKCSKPEVEVGVKHVTCTEDAAAFVALAAAMDLSMDACQSFSQKLRKELRQQSQNFVD</sequence>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB18987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="143" mass="15687" checksum="99DE4719D8BDA336" modified="2015-04-29" version="1">MGSDFYFPPFPPKPNNKLRLIMFVCLVMSTHFPLPPFPPKPKFLQAKPKPSFKLCSSLSTVSVPPTKTSHKPFPTEVSRTIMELSSIGTLSTLAQDGWPLGVGLRFVVDAEGTPVLCLPQPSPDAMWVTDSSVYNTGQSYQTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MMV3</accession>
    <name>A0A0D2MMV3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein ABIL2</fullName>
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        <name evidence="4" type="ORF">B456_003G121700</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Malvales</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
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                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Tang H."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NBW1"/>
    <dbReference type="STRING" id="29730.A0A0D2NBW1"/>
    <dbReference type="Gramene" id="KJB10413">
        <property type="protein sequence ID" value="KJB10413"/>
        <property type="gene ID" value="B456_001G245200"/>
    </dbReference>
    <dbReference type="OMA" id="KCFVVPI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31929">
        <property type="entry name" value="SAUR-LIKE AUXIN-RESPONSIVE PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB10413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="83" mass="9210" checksum="6DCFCFE02CA0EF92" modified="2015-04-29" version="1">MGFHLPRIVNAMPSLKRSLSSSEIIMVPKGNFAIYVGEVNEKKCFVVPISLLKHPSFPKLLSQPEEEFGFNHPKGALTIPCSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGY2</accession>
    <name>A0A0D2NGY2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G221100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGY2"/>
    <dbReference type="STRING" id="29730.A0A0D2NGY2"/>
    <dbReference type="Gramene" id="KJB32062">
        <property type="protein sequence ID" value="KJB32062"/>
        <property type="gene ID" value="B456_005G221100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795078"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000004">
        <property type="entry name" value="Outer envelope protein 64, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF4">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 64, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="69"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="487"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="521"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="555"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="603" mass="65870" checksum="0BC664FB0CF68616" modified="2015-04-29" version="1">MSKTLNLIKTNASNPKVWIVAGITVAGIIVVAETRRRRKKAMIIKREDFGAFMERFELIPFPQPPPPAAKLPLLGLTFAIKDIFDVKGHATGFGNPDWQRTHEVADKTAVVVTALLKNGAKCVGKTVMDELAFGITGENKHYGTPTNPNMPSNVPGGSSSGSAVAVAAELVDFALGTDTIGCVRVPASFCGILGFRPSHGAVSTIGVLPNSQSLDAIGWFARDPSILHRVGNVLLQLKAVEPRRGRHLVFADDLFQLSKVPKQKTVHVISKAVEKLSGYQLPKHVNFCQFIASNVPSLKGFFQHSTNLQNGISALQALSSAMVSLQRYEFKTNHEEWLKDVKPRLGPEVSRCVLAAINNTYENVKSLYKVRTEMRAATQSLLKDDGILVIPTIADPPLKLKKGSSTEFHDRACALLSVASMSGCCQVSVPLGEHDGCPISVSFVTYHGADKFLLDTVLDMYASLQEQVSMASNSAPLPDLNGNMDASELLKEKGNAAFKGKQWNKAVNYYTEAIKLNGTNATYYNNRAAAYLELGCFQQAEEDCNKAISLDKKNVKAYLRRGTARDSLLCYKEALEDFKHALVLEPQNKVANLAERRLRKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKQ8</accession>
    <name>A0A0D2NKQ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Pectate lyase</fullName>
            <ecNumber evidence="4 10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_006G024800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKQ8"/>
    <dbReference type="STRING" id="29730.A0A0D2NKQ8"/>
    <dbReference type="Gramene" id="KJB33662">
        <property type="protein sequence ID" value="KJB33662"/>
        <property type="gene ID" value="B456_006G024800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798260"/>
    <dbReference type="eggNOG" id="ENOG502QQE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIHHICQ"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
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        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF184">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
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        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="178"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="454" mass="51918" checksum="9FB4C4A5325508CA" modified="2015-04-29" version="1">MEVTKLRLVFFFSFAFIITRLLANIIEIDDFWKQREQEAWNITLAAYESSPENIINHLNYNVDKVIRKISANQTIEFEDDLTNNTRRYLRGKHKKYTGPCMATNPIDSCWRCKKNWAKNRKILAKCVLGFGHKTSGGSNGDYYLVTDNSDDDVLNPKPGTLRHAVIQKRPLWIIFARTMHIKLSQELIVQSNKTIDGRGADVHIAYGCGITLQFVHNVIIHNIHIHHIFPSSGGLIRDSEDHFGFRTVGDGDGISIFGSSNIWLDHISMSEGQDGLIDAIQGSTAITISNCHFTHHNDVMLFGASDAYSKDQFMQVTIAFNHFGKELIQRMPRCRWGFFHVVNNDYTHWKMYAIGGSMHPTIISQGNRFIAPHDLNAKEVTHRIYASESEWKNWVWRSEEDLLMNGAIFRTSGPLSPPDLKFNQKDIIKAKPGTYVRTLTRFAGTLKCKKRIKC</sequence>
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    <accession>A0A0D2NSG3</accession>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="3" type="ORF">B456_006G137500</name>
        <name evidence="4" type="ORF">Gorai_000949</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NSG3"/>
    <dbReference type="STRING" id="29730.A0A0D2NSG3"/>
    <dbReference type="Gramene" id="KJB36022">
        <property type="protein sequence ID" value="KJB36022"/>
        <property type="gene ID" value="B456_006G137500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4TC">
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33429:SF19">
        <property type="entry name" value="FISSION REGULATOR-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33429">
        <property type="entry name" value="OS02G0708000 PROTEIN-RELATED"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB36022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0587828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="103" mass="11087" checksum="B20E1E88B273DFE4" modified="2015-04-29" version="1">MEAGSNNQYVPVVEVPPTVREPSRYSHRSIETLIVVLAAITIIGVIAGIIARLCGGRHFGGNGENDIEGWIENKCRSCIDGGVPAAVPPPKEEPKPAREEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2Z5</accession>
    <name>A0A0D2P2Z5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="11">Ribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_007G045600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Cytoprotective ribonuclease (RNase) required for resistance to abiotic stresses, acting as a positive regulator of mRNA decapping during stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic granule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2P2Z5"/>
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        <property type="gene ID" value="B456_007G045600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802140"/>
    <dbReference type="eggNOG" id="KOG2039">
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
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    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="13">
        <location>
            <begin position="10"/>
            <end position="152"/>
        </location>
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    <feature type="domain" description="TNase-like" evidence="13">
        <location>
            <begin position="187"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="13">
        <location>
            <begin position="381"/>
            <end position="559"/>
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        <location>
            <begin position="588"/>
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        <location>
            <begin position="782"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P9I2</accession>
    <name>A0A0D2P9I2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transposase-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G100000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB23468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G100000"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029480">
        <property type="entry name" value="Transpos_assoc"/>
    </dbReference>
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        <property type="entry name" value="Transpos_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transposase-associated" evidence="1">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="213" mass="24448" checksum="3427CE48F3F90B70" modified="2015-04-29" version="1">METLGRVSLDYLWRHFLGSPRLLIVETPIIISTLDKSWIDAPKFSMVYMNGIASFIEYATKNSTNNQNIYFPCKKCYNRFLLRPKVVHNHLRLYCFVKWYKRWIFHGKTSASIFSSNSPNMASHTRSLNDIDVDLGTRDLIMEVIGLNVPVHDRDEFSHGDHVNGGGDVVSTLLPSEDVGRTTGEILWMIARYLFIPIVKNSLPYHSSCDSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P9Q9</accession>
    <name>A0A0D2P9Q9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">VAN3-binding protein-like auxin canalisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G103900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P9Q9"/>
    <dbReference type="STRING" id="29730.A0A0D2P9Q9"/>
    <dbReference type="Gramene" id="KJB23538">
        <property type="protein sequence ID" value="KJB23538"/>
        <property type="gene ID" value="B456_004G103900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793582"/>
    <dbReference type="eggNOG" id="ENOG502QQ2J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEACHET"/>
    <dbReference type="OrthoDB" id="786244at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013666">
        <property type="entry name" value="PH_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040269">
        <property type="entry name" value="VAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008546">
        <property type="entry name" value="VAN3-bd-like_auxin_canal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31351:SF25">
        <property type="entry name" value="AUXIN CANALIZATION PROTEIN (DUF828)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31351">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05703">
        <property type="entry name" value="Auxin_canalis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08458">
        <property type="entry name" value="PH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VAN3-binding protein-like auxin canalisation" evidence="1">
        <location>
            <begin position="12"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Pleckstrin-like plant" evidence="2">
        <location>
            <begin position="277"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB23538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43424" checksum="B614AD3C3C5E0819" modified="2015-04-29" version="1">MDFNSTPSPSEACHETMDFLSRTWCNFAVQALQPQLHDQSIVVLDNQIKALESETSLSFTNTEKSAKIDATDFKSSLPPWKSDDVKSWIWMQQAMHPELNYNSCFRKKWMPWKIVPFKGVSIKKWMKEMKGKRKEKDRLQRAEVQSAISVAGLAAALAAVAAENSKREYCSPTKEAAVASAAALVAAQYAKVAEAMGAKKEQLGSVIASTMSGTTASEILTLTAAANTSLRGAAILKAKTGCKNRFNGSAPLLPFEDSNDLPFEFDKCRSMLAKGAELGVETPDGKYMVRWASIDLDGDSKVIIKLRKLSLFKSKKERIILGLHADLYRDPEADETTDTCYVIVLTTNSGMVKLDMVDDYQLYKTWSTTIYDMLMISTSLTKYDLQFYKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PY07</accession>
    <name>A0A0D2PY07_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Heparanase-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G196400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Endoglycosidase which is a cell surface and extracellular matrix-degrading enzyme. Cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Lysosome membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 79 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PY07"/>
    <dbReference type="Gramene" id="KJB50982">
        <property type="protein sequence ID" value="KJB50982"/>
        <property type="gene ID" value="B456_008G196400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764689"/>
    <dbReference type="eggNOG" id="ENOG502QT4G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNYICAT"/>
    <dbReference type="OrthoDB" id="726732at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004566">
        <property type="term" value="F:beta-glucuronidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000023">
        <property type="entry name" value="heparanase-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005199">
        <property type="entry name" value="Glyco_hydro_79"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363:SF21">
        <property type="entry name" value="HEPARANASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14363">
        <property type="entry name" value="HEPARANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03662">
        <property type="entry name" value="Glyco_hydro_79n"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249319" description="Heparanase-like protein 1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB50982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="60405" checksum="F0B5B63381B258E8" modified="2015-04-29" version="1">MELCFGWFLLVASIPAIFAQDISHGSIVVDGTMTVAQTDDNFVCATIDWWPHDKCNYDQCPWHYTSVMNLNLSHPFLAKAIQAFNRLRIRVGGSLQDQVLYDVGNLKSPCHPFQKMKDGLFGFSKGCLHMERWDELNRFFKETSAMVTFGLNALHGRHKIKRSLWGGDWDSSNAQDFMKYTISKGYQIDSWEFGNELSGNGIGAHVHADQYGKDLVNLRKIINELYKGSQSKPSLIAPGGFYDEEWFVKLLQTSGFGVIDVMSHHMYNLGAGVDPKLVSKILNPDHLNKAAYTFGNLTHIIRRHGPWTSAWVGESGGAYNSGGAHVSNTFINSFWYLDQLGMASKYHTKVYCRQTLIGGNYGLLNATTFVPNPDYYSGLLWHRLMGKVVLNVESHASPFLRSYAHCSKGRAGVTLLVINLSNQTNFIMNAQNSINLKLAAIEQNISRDSFTHNLKKTFSWVGTKASDDALLREEYHLTPKDGYLRSQTMVLNGIPLELTRTGDIPSLNPVRVNVKSPITISPLSIAFIVFPNFEAPACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q7C6</accession>
    <name>A0A0D2Q7C6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G035000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q7C6"/>
    <dbReference type="STRING" id="29730.A0A0D2Q7C6"/>
    <dbReference type="Gramene" id="KJB12756">
        <property type="protein sequence ID" value="KJB12756"/>
        <property type="gene ID" value="B456_002G035000"/>
    </dbReference>
    <dbReference type="OMA" id="CMTHEFY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF198">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="306" mass="34614" checksum="8D2F9F6ED8BEB5E0" modified="2015-04-29" version="1" fragment="single">NGDDGASSLWESFEDPSNVFIETMKISTDVKKGRKVELKSWKSIDDPSDGNFSLGFEPFNIPEGIIRKKNQLYFRTGPWNGYTFIGLINMYTSYLQGFVVVADNPQQPYCMTHEFYTDSILIYGELDSQGKFIERRWDAGKGNWINKYSSYQTDCDVYGYCGAFGICDSSKQPICSCLKRFKPRNIEEWSRGNWSSGCFRTTPLQCQRDNNNGSGAGQGDDGFLEMKNMKVPVFRHPSSVSNGECKDQCMKNCSCVTYAYDDGIGCMLWSGDLIDISPLAESIFTFVCHLRNSIKGNILRSLLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBA1</accession>
    <name>A0A0D2QBA1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G241100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QBA1"/>
    <dbReference type="STRING" id="29730.A0A0D2QBA1"/>
    <dbReference type="Gramene" id="KJB16639">
        <property type="protein sequence ID" value="KJB16639"/>
        <property type="gene ID" value="B456_002G241100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFDIINC"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11064">
        <property type="entry name" value="CYP86A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB16639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="56392" checksum="FBE5D1D50F9AB352" modified="2015-04-29" version="1">MELQASLFFWILIFLLYLLFSLLIKPKLWCNCEICSAYLTLSWSKQFNNLCDWYTHLLKNSPSKTIHIHVLRNTITANPENIEYMLKTKFHNFPKGKPFSIILGDFLGRGIFNVDGDSWKFQKNMASMELGKTSTCCYVFDIINCEIKTRLVPLLSKQDQVLDLQDVFKRFSFDVICWFSFGIDPSCLELSLPMSKLAMAFDLASKLSAERAMNVSPLVWKIKRALNLGSEKELKRAIERINLLAKEVIRQRRKTGFLNSNDLLSRFMSIINDETYLRDIIISFLLAGRDTVASGLTSLFWLLSKHSNVVSAIKQEADRIIGENKELTCFDQMKELHYLQATVYESMRLYPPIQFDSKFCQNDDVLPDGSVLKKGTRVTYHPYAMGRIEEIWGEDCLEFKPERWLKHDGVFSPGNPFKYPIFQAGFRVCLGKEMALLEMKTVTLSLIRRFRIQLLTPPSPDQHPRFLPGLTATFSDGLPVLVRNIQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEJ4</accession>
    <name>A0A0D2QEJ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G020600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEJ4"/>
    <dbReference type="STRING" id="29730.A0A0D2QEJ4"/>
    <dbReference type="Gramene" id="KJB17869">
        <property type="protein sequence ID" value="KJB17869"/>
        <property type="gene ID" value="B456_003G020600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3WW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRFCIAN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039218">
        <property type="entry name" value="REM_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM-LIKE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31674:SF62">
        <property type="entry name" value="B3 DOMAIN-CONTAINING PROTEIN REM14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="164"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="332"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB17869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="49599" checksum="1239EAD298D73C48" modified="2015-04-29" version="1">MTRKPKRSPSFFKILVGDFVTKLKIPPAFLKYVLKGKVPTMFSLYSDSGNSWRVRVEVQQGSYFFNSGWSKFVKYHGLEIGDFLVFFLVDSSTFDVFIYNRTACAKNIILAAKKPKGRPPGGNRQIEQTPSQKCTSASKKPRAVSRARNVSQEVEFIKEETPKHVSFVLVVKKYLKYYVFIPRYFAKETGLGKESITIIKGPRGGMWPMNTTESGRQVRLGGGWSQFLHENDIVVGDTLLFQHIPNASNLVHVQILNKAGYRNHGRGGRRGRQNKQANASEKNTIIAIKQKRGPPCRQIEEPNSKITKGLSIGGERDITRKDEFESELTPKKASFVVVLKQYQKFYIPVPTSVAKEMGLTKEPSTVIKDSKGRKWRLNILVYARSVHLGAGWSKFMEENKLEVGDTLLFQHIPNTGNVIYFHIIRKARDGNHGKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEU7</accession>
    <name>A0A0D2QEU7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-dependent kinase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G221900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDI family. ICK/KRP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEU7"/>
    <dbReference type="STRING" id="29730.A0A0D2QEU7"/>
    <dbReference type="Gramene" id="KJB37818">
        <property type="protein sequence ID" value="KJB37818"/>
        <property type="gene ID" value="B456_006G221900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800366"/>
    <dbReference type="eggNOG" id="ENOG502QXA1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTPTSHE"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044275">
        <property type="entry name" value="KRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46776">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017811">
        <property type="entry name" value="CDK_inhib_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="6">
        <location>
            <begin position="212"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB37818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="258" mass="29024" checksum="8FDDEE0316BD01BE" modified="2015-04-29" version="1">MGKYIRKARTAGEVAVMELSQASLGVRTRAKTLALQRLQQSSTSSPPTVVSAPATGDGSFLQLRSRRLEKPPLVVHHHVSKRHKQQQQGSKKDSCVQNPNPNSYSRVRPCGGSNSEKKKGEDIVQEDNGNDNIINYSNLNNNHNESNDFGGVEASFGENILDMEARERGTRESTPCSLIRDSESIRTPGSATRPPNSADTNQRVQNSTWRHTPTSHEMDEFFSLTEEDQQRQFIEKYNFDPVKDKPLPGRYQWEKMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFT0</accession>
    <name>A0A0D2QFT0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Beta-galactosidase</fullName>
            <ecNumber evidence="4 11">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_002G197100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 11"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QFT0"/>
    <dbReference type="Gramene" id="KJB15806">
        <property type="protein sequence ID" value="KJB15806"/>
        <property type="gene ID" value="B456_002G197100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FEYHIPR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000050">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000006">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249752" description="Beta-galactosidase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="14">
        <location>
            <begin position="55"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase beta-sandwich" evidence="15">
        <location>
            <begin position="393"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="16">
        <location>
            <begin position="638"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF17834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB15806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="754" mass="85441" checksum="70B79627D4225E19" modified="2015-04-29" version="1">MVEPRRLLMIFFLSTLLIAYSNANVEEIQKDTEEGDEEGKVGGQKAQGVTYDARSLIINGKRELLFSGAIHYPRSTPDMWPDLIKKAKQGGINTIETYVFWNGHEPVEGQYNFEGEFDLVKFIKLIHEHKLYAVVRVGPFIQAEWNHGGLPYWLREVPDIIFRSDNEPFKKHMKRFVTMIVDKLKQEKLFAPQGGPIILAQIENEYNTIQRAFREKGDSYVQWAGKLALSLNANVPWIMCKQRDAPDPVINTCNGRHCGDTFYGPNKRNKPALWTENWTAQYRVFGDPPSQRSAEDLAYSVARFFSKNGSMVNYYMYYGGTNFGRTSASFTTTRYYDEAPLDEFGLQREPKWGHLKDVHRALSLCKRALFWGVPTTLKLGPDQQAIVWQQPGTSACAAFLANNNTRLAQHVNFRGQDIRLPARSISVLPDCKTVVFNTQLVTTQHNSRNFVRSEIANKNFNWEMYREVPPVGLGFKFDVPRELFHLTKDTTDYAWYTTSLKLGRRDLPMKKNVSPVLRVASLGHGIHAYVNGEYAGSAHGSKVEKSFVFQRAVSLKEGENHIALLGYLVGLPDSGAYMEKRFAGPRSITILGLNTGTLDISQNGWGHQVGIDGEKKKLFTEEGSKSVQWTKPDQGGPLTWYKGYFDAPEGDNPVAIVMTGMGKGMVWINGRSIGRYWNNYLSPLKKPTQSEYHIPRAYLKPKNLIVLLEEEEGNPKDVHIVTVNTDTICSAVSEIHPPSPRLIETKMYSPTQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJA4</accession>
    <name>A0A0D2QJA4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G008100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJA4"/>
    <dbReference type="STRING" id="29730.A0A0D2QJA4"/>
    <dbReference type="Gramene" id="KJB39353">
        <property type="protein sequence ID" value="KJB39353"/>
        <property type="gene ID" value="B456_007G008100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801745"/>
    <dbReference type="eggNOG" id="KOG2090">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ALMFEYM"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000019">
        <property type="entry name" value="Mitochondrial intermediate peptidase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="11">
        <location>
            <begin position="259"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB39353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="725" mass="82718" checksum="678B984599CD2DE5" modified="2015-04-29" version="1">MWNFIKNREPNIHMKRLFEPFLSYRHFRTRAVDRQNTSSTGLYGFDHLKSPKGFQRFVDEAIERSSELIDYISGMPSSAEIIRAMDEISDTVCSVVDSAELCRQTHPARGFVEEAIKASMKINVYLHFLNTNHTLYNAVKKAEQDGHLLTEEARRAALHLRIDFEKGGIHLPSGKLDRVNQLNMDAHKLCREYGENIINDPGYVDIFPASRIPRQIQHLLKPIYRLTSGVSKESLGSYEDEQEKGFRIITEPRTLFSVLQLTPDEQVRKMAYLKGSSIPHANHEVLDKLINSRHELAQIMGCKSYAEFVMQLNMASSPEVVVSFLQEMSNMVKEKADEEFNTIRNLKRDLCGQRCVDLEPWDEAYYTTMMKSSAYNLDSAVVASYFSLPQCIEGLKLLVKSLFGASFDSVPMAPGESWHPDVLKMCIHHPEEGDLGFLYLDLFSRKGKYPGCATFAIKGGRKISETEYQLPVMALVFNFSRSHDSSIVRLNHSELETLFHEFGHALHALLSRTDYQHFAGTRVALDFAETPSNLFEYYARDYRVLKKFARHYSTGEVIPEKLVKSLNGARDMFAATELQRQIFYALVDQTLFGEQLSVPRDTNSIVAHLKRQHSNEKHVEGTHMHIRFSHFLTYGAGYYSYLYAKCFAATIWKKLCQEDPLSPTTGTLLRTKLLQYGGAKEPADLLTDLVGDGIVRYHNGGIVPDVTSCLEEMKLLDDKNRHISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJP2</accession>
    <name>A0A0D2QJP2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G266600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJP2"/>
    <dbReference type="STRING" id="29730.A0A0D2QJP2"/>
    <dbReference type="Gramene" id="KJB17126">
        <property type="protein sequence ID" value="KJB17126"/>
        <property type="gene ID" value="B456_002G266600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1759">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.429.10:FF:000004">
        <property type="entry name" value="Tautomerase/MIF superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF42">
        <property type="entry name" value="TAUTOMERASE_MIF SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="154" mass="16938" checksum="CABAFCDC5EAE38D6" modified="2015-04-29" version="1">MPCLNLSTNVNLDGVDTSAILSEATSSVAKLIGKPEAYVMIVLKGSVPMSFGGTEQPAAYGELVSIGGLNPDVNKKLSAAIAAILETKLQVPKSRFFLKFYDTKARFQLWMERIHLLSLACSEFLETSVMSIQNNLTRTVNWCEKKFLKLGMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQT9</accession>
    <name>A0A0D2QQT9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G027000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQT9"/>
    <dbReference type="Gramene" id="KJB22044">
        <property type="protein sequence ID" value="KJB22044"/>
        <property type="gene ID" value="B456_004G027000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790186"/>
    <dbReference type="eggNOG" id="ENOG502RMNH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEHCGIN"/>
    <dbReference type="OrthoDB" id="1928288at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167:SF33">
        <property type="entry name" value="MYB-CC TYPE TRANSCRIPTION FACTOR LHEQLE-CONTAINING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33167">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (DUF863)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="214" mass="23882" checksum="A9EF6E91EB221C6A" modified="2015-04-29" version="1">MGTELEHCGINPIIGSSESNSMEIRVNNMESIKETMQMHEDMFQHQVRELHRVYSVQKALMEELKKGIKSNRLWATPMVTSSHISQSQLINHHQHSTTPLQITCGYNPNLEADPSLRERTSGCSGDHIHAMKLAKGFDLERPAGENSDEDSEVELTLSIGGASKKKKSKGGEISNRGSFKSESGDDFIGPNTPPLLSFPWLKHKQDLHLPLNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRH0</accession>
    <name>A0A0D2QRH0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G125400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRH0"/>
    <dbReference type="STRING" id="29730.A0A0D2QRH0"/>
    <dbReference type="Gramene" id="KJB41873">
        <property type="protein sequence ID" value="KJB41873"/>
        <property type="gene ID" value="B456_007G125400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802988"/>
    <dbReference type="eggNOG" id="ENOG502S1Y2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEIRYWR"/>
    <dbReference type="OrthoDB" id="1898021at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33702">
        <property type="entry name" value="BNAA09G40010D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33702:SF5">
        <property type="entry name" value="OS01G0308600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB41873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="16261" checksum="2C7458E02CD6FBB3" modified="2015-04-29" version="1">MEGISATMYKNLTGYWRRRGYVKLNGTSGARRSRVELGSSRRKRFWKIRIKAKLRIRSPKKWLVWLRDAYVKMMLGLANSRMVSSGYGGSITDQGIAAFGKRPVKEYDEKVIVEIYKSLVMAQGQLVPREPGKLCSAIICQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRS9</accession>
    <name>A0A0D2QRS9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G175300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRS9"/>
    <dbReference type="STRING" id="29730.A0A0D2QRS9"/>
    <dbReference type="Gramene" id="KJB09925">
        <property type="protein sequence ID" value="KJB09925"/>
        <property type="gene ID" value="B456_001G175300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1913">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEMASKW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF17">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="534"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="718"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="502"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB09925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="776" mass="85429" checksum="E730FF12FD8A22FB" modified="2015-04-29" version="1">MASPQFEVEDQLDEDFFDKLVNDDDDFDFTGSTGKHVVEAADFEEVKGFSNLTISETSPTGVESGGKDIDIGTEAEKGVEDAAISELLAANEDNVAAKESSSQLPSNVKECSVMETGEEGVLDGGTSKSDVASGIGVKEVQWSSLNSDSNVINAGGSRTFSEIFNDLGDNSEDPFAEVGNKDDLLKEFNGSTVSVPGNSFSDLASSSHPENNDVQYYGMGLEQNVDGQEFSNYQSWENLYPGWKYDPNTAQWYQVEGYVNTFMNSQESFGVTHSDNGDHFSDRKMDVPSLQKTTQSSVGTLAEDFGNSNTSNWNQISQGNAEYPAHMVFDPQYPGWYYDTIALEWKMLEPYTSAVDQSATMDNDQQYQNKNIESYEFQALGSQDLYMNQCASASNYHQQNSNSFQDYSVSKNGRDFSSETKQLGNIYSPADHVDNHAEQKNEFDASRLVAPYKQQSQTFLHGSEISRFQSFIPAQSYTQFSNQTTVQPDQQMQFIPAFIDAQKSGDHPQQPLQIGTPFSSSPNEGRSSAGRPPHALVTFGFGGKLLVMRNNSLSHTTAPYGNQGSVGGVVSVLNLVEVVMDNSNASSFGFGAQDYFQTLCQHPLPGPLVGGNVGNRELYKWIDERIANCESSSLGYRGDVLRLLLSLLKISCQYYGKLRSPFGTDQTSKESDCPELAIAKRLGSVKGKGVQSGLYSAVVHCFQNLPSEAQMQATALEVQRLLVSGRKKEALEFAQEGQLWGPALVIASQLGDQVIVITFYLYLLFYCMYMFRIYNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSI6</accession>
    <name>A0A0D2QSI6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Xyloglucan endotransglucosylase/hydrolase</fullName>
            <ecNumber evidence="13">2.4.1.207</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G337400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes xyloglucan endohydrolysis (XEH) and/or endotransglycosylation (XET). Cleaves and religates xyloglucan polymers, an essential constituent of the primary cell wall, and thereby participates in cell wall construction of growing tissues.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Secreted</location>
            <location evidence="13">Extracellular space</location>
            <location evidence="13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="13">Contains at least one intrachain disulfide bond essential for its enzymatic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.207" evidence="13"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSI6"/>
    <dbReference type="STRING" id="29730.A0A0D2QSI6"/>
    <dbReference type="Gramene" id="KJB60992">
        <property type="protein sequence ID" value="KJB60992"/>
        <property type="gene ID" value="B456_009G337400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766017"/>
    <dbReference type="eggNOG" id="ENOG502QQ71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKIMNNG"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016762">
        <property type="term" value="F:xyloglucan:xyloglucosyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02176">
        <property type="entry name" value="GH16_XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000025">
        <property type="entry name" value="Xyloglucan endotransglucosylase/hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044791">
        <property type="entry name" value="Beta-glucanase/XTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008263">
        <property type="entry name" value="GH16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010713">
        <property type="entry name" value="XET_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016455">
        <property type="entry name" value="XTH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31062">
        <property type="entry name" value="XYLOGLUCAN ENDOTRANSGLUCOSYLASE/HYDROLASE PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06955">
        <property type="entry name" value="XET_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005604">
        <property type="entry name" value="XET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01034">
        <property type="entry name" value="GH16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="1 13" id="KW-0134">Cell wall</keyword>
    <keyword evidence="10 13" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113217" description="Xyloglucan endotransglucosylase/hydrolase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="14">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="12">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005604-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB60992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="32945" checksum="8AC08A8CB99C7CF4" modified="2015-04-29" version="1">MSYSSSSKFPLLMPLMVACLIMAASGSNFHNDFDITWGDGRGKIVNNGEVLTLSLDKQSGSGFQSKNEYLFGKIDMQLKLVPGNSAGTVTAYYLSSKGTTWDEIDFEFLGNLSGDPYILHTNVFSQGKGNREQQFYLWFDPTTDFHTYSILWNPERIIFSVDDTPIREFKNMESIGVPFPKNQPMRIYSSLWNADDWATRGGLVKTDWTQAPFTASYRNFNADACVWSNGASSCKSNAPSSSTSTNNAWLSQEMDSAKQQRLQWVQQNYMIYNYCTDAKRFPQGLPSECKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVW9</accession>
    <name>A0A0D2QVW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G2423002</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVW9"/>
    <dbReference type="STRING" id="29730.A0A0D2QVW9"/>
    <dbReference type="Gramene" id="KJB21296">
        <property type="protein sequence ID" value="KJB21296"/>
        <property type="gene ID" value="B456_004G2423002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21297">
        <property type="protein sequence ID" value="KJB21297"/>
        <property type="gene ID" value="B456_004G2423002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21298">
        <property type="protein sequence ID" value="KJB21298"/>
        <property type="gene ID" value="B456_004G2423002"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792532"/>
    <dbReference type="eggNOG" id="ENOG502QW59">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1848055at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056253">
        <property type="entry name" value="At2g29880-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46929:SF8">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24769">
        <property type="entry name" value="At2g29880_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="178"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="342"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="504"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="656"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="At2g29880-like C-terminal" evidence="3">
        <location>
            <begin position="898"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB21296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="947" mass="110836" checksum="D4335A0042383BBF" modified="2015-04-29" version="1">MGSNAPSSSDRTRTNWTPTMERFFIDLMLDQMHRGNRLGHTFNKQAWTDMLSIFNVKFGCKYDRDTLKSHYTNLWKQYNDVKNLLEQNGFSWDDTRKLVVAPPHVWNAYIKGQPDAQVYRNRTLTNFSDLCLIYAYTQADGRYSRSSHDIDFDDDALGVNFGVGSSVPAVSDENLNIEWTPAMDQYFIEIMLENLRKGNKSKSTFSKQAWNDMLGSFNAKFCFQFSKSFLRRRYRKLLKHYSDVQSLLLQKGFSWDDKQKMIVADDLVWDNYIKAHPDAHTFRNKKMLNYRDLRLIYKNASNSVVSSHMRQGRYTGPKTLPVWTGEENRGHLHDRDEMLGPHWTSAMNRHLIDLLLNQALGGNKIGHAFVPEAWNQIVAMFNVKFGCHYDEEALKSQARHLRRQYNNIKILLEQNGFSWDDKREKVIAADHVWDAYMKEHPNTQSYRHKMVPDYHKLCVIFGQESSNGMCSMAQREHPENEDPDLMIGDDSQFHARNGYSRIDWTPSMERHLIDLLLKQVHRGNMMSGALDTEVWLDMCLSFMESFGLQPDEESLKDHHKSLGKQYRDMRILIDQRVFSWDETRQMLTARDDVWEAYTKEYPDVVSYRHKRKPNYNDLCLIYGNSTDRKDRRSGRDACCNGYGTILKNGYYGRTDWIPSMDRYFIDLMLEHVRQGSMIDKKFSKLAWGDMVAKFSAEFGYQYDKDVLKSRFMNLRKRFNDMKYLLDHDGFTWDEKRQMIIADDHLWAIYLKEHPDARSYRNRTLPSYNDLFLIYGNANINGWNLEAENSSGEEEDESPFSSSPTRIHKTGSAGVKSDIDNDVLDTGFNDIFGDLQSLAAEFEIPDQRKKRKTDASSMAASRKAVRTNQGRLHPSDKRPVKVRTSFNNEDQYYSSIESIVDALQAIPGMDDVLFLDASKLLEDEKKARMFVAMDVHQRRKWLLRKLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZL7</accession>
    <name>A0A0D2QZL7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G025300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZL7"/>
    <dbReference type="STRING" id="29730.A0A0D2QZL7"/>
    <dbReference type="Gramene" id="KJB12585">
        <property type="protein sequence ID" value="KJB12585"/>
        <property type="gene ID" value="B456_002G025300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787147"/>
    <dbReference type="eggNOG" id="ENOG502RXP0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NADQDYV"/>
    <dbReference type="OrthoDB" id="1708403at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052426">
        <property type="entry name" value="Plant_dev_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801">
        <property type="entry name" value="OS07G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801:SF110">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR SUPERMAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="70"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="206" mass="23211" checksum="0AA80621D1080E3F" modified="2015-04-29" version="1">MERKTAAIKDQTSCYRKRNTNVKESSPWSCCNNQGFGSGGEDYLSGFSWPPRSYTCSFCKREFRSAQALGGHMNVHRRDRARLRQSPPPPPKDHHHHHHGQPPFLNLNLNPNPNPNFSPPSSLTLSTFPPPSPSLSPAKKWLFIDPLNSKPSDSRKGVERDRHSSLGSRPILGVKELKDYVTLDLEIGLVNDSKQDLDLELRLGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R126</accession>
    <name>A0A0D2R126_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription termination factor MTERF4, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial transcription termination factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G084100</name>
        <name evidence="13" type="ORF">Gorai_014359</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R126"/>
    <dbReference type="STRING" id="29730.A0A0D2R126"/>
    <dbReference type="Gramene" id="KJB23154">
        <property type="protein sequence ID" value="KJB23154"/>
        <property type="gene ID" value="B456_004G084100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB23155">
        <property type="protein sequence ID" value="KJB23155"/>
        <property type="gene ID" value="B456_004G084100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB23156">
        <property type="protein sequence ID" value="KJB23156"/>
        <property type="gene ID" value="B456_004G084100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790761"/>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMDYDTI"/>
    <dbReference type="OrthoDB" id="637682at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009793">
        <property type="term" value="P:embryo development ending in seed dormancy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042794">
        <property type="term" value="P:plastid rRNA transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000004">
        <property type="entry name" value="Transcription termination factor mterf4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000005">
        <property type="entry name" value="Transcription termination factor MTERF4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF109">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="495"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB23156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0583505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="524" mass="59038" checksum="1D2D369A0826C2EB" modified="2015-04-29" version="1">MKIRSCVGITKPSLLLVHSELPALTFHKTKLTWTSTLRFPSNYERTSGSVTRFHCSVAGRTGASTSVSSSSSKSNTVHLSRKQVKPSSLYSRPSLSNMKKERIANRAKVYEFLRVLGIIPDELDGLELPVTVEVMQERIDFLHKLGLTIEDINNYPLVLGCSVKKNMIPVLDYLGKLGVRKSTFTEFLRRYPQVLHASVVVDLAPVVKYLQGLDIKPNDIPRVLEKYPEVLGFKLEGTMSTSVAYLVGIGVSRREVGGVLTKYPEILGMRVGRVIKPFVEYLEGLGIPRLAIARLIEKRPHILGFGLEERVKPNVASLLEFNVRKASLPSIVAQYPEIIGIDLKPKLLGQRSLIQSIIDLEPEDFGTVVEKMPQIVSLSNTSMVKHGDFLKGCGFSLQQVRSMVVECPQILALNLDIMKLSFDYFQMEMQRPLDDLVAFPAFFTYGLESTIKPRDKIVAKKGFKCSLSWLLNCSDEKFKERLNYDTIEMEEMETMPSFDMNSLMEPRSDESDSDYEEDSDDEYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2W1</accession>
    <name>A0A0D2R2W1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_010G060600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2W1"/>
    <dbReference type="STRING" id="29730.A0A0D2R2W1"/>
    <dbReference type="Gramene" id="KJB64687">
        <property type="protein sequence ID" value="KJB64687"/>
        <property type="gene ID" value="B456_010G060600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772283"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QFIFEME"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF267">
        <property type="entry name" value="EXOSTOSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="8">
        <location>
            <begin position="147"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB64687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="482" mass="54610" checksum="BCC0F82D60DF693C" modified="2015-04-29" version="1">MAEVGCHNINCLLLSASLAFCLLVWYLSSPLKYQSKLTILFSTFPPNSHIKTSQETAPSSPPSPPPSAASPAPLTSLNATTGGDAITRPNKRKSSLEKVEEGLAKARAAIREAILVRNYTSYKKETFVPRGIIYRNPYAFHQSHIEMEKRFKVWVYREGEPPLVHGGPVSNIYGIEGQFIDEMESGKSRFLARHPEEAHAFFIPISVANIVKVLYRPLVTYSRDQLHRVVADYVGVVAQKYPYWNRSNGADHFLISCHDWAPDIGDSNPALFNNFIRVLCNANTSEKFNPRRDVSMPEINIPKAQLGPPHLDLPPVNSSILAFFAGGAHGYIRKLLLEHWKDKDEEVQVHEYLSKEKDYFKLMGETKFCLCPSGYEVASPRVATAISVGCVPVIISDNYALPFSDVLDWSEFSVHIPSERIPEIKRILKGISEKKYLKLQKRVRQVRRHFVLNRPAKPFDVIYMLLHSVWLRRLNFRVPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4D6</accession>
    <name>A0A0D2R4D6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G138600</name>
        <name evidence="12" type="ORF">Gorai_014733</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4D6"/>
    <dbReference type="STRING" id="29730.A0A0D2R4D6"/>
    <dbReference type="Gramene" id="KJB24311">
        <property type="protein sequence ID" value="KJB24311"/>
        <property type="gene ID" value="B456_004G138600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791396"/>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTETHEW"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000012">
        <property type="entry name" value="Heat shock cognate protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="33"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="680"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="680"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="126"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB24311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0583892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="704" mass="81025" checksum="B12D4541E740ED09" modified="2015-04-29" version="1">MADVHMGSESETFAFQAEINQLLSLIINTFYSNKEIFLRELISNASDALDKIRFEGLTDKSKLDAQPELFIRIIPDKANKTLSIVDSGVGMTKADLVNNLGTIARSGTKEFMEALQAGADVSMIGQFGVGFYSAYLVAEKVIVTTKHNDDEQYIWESQAGGSFTVTRDLGGEPLGRGTKITLFLKEDQLEYLEERRIKDLVKKHSEFISYPIYLWTEKTIEKEVSDDEDEETKKEEEGDVEEVDEDKEKKSKKKKVKEVSHEWQLINKQKPIWLRKPEEITKEEYASFYKSITNDWEDHLAVKHFSVEGQLEFKAILFVPRRAPFDLFDTRKKLNNIKLYVRRVFIMDNCEELIPEYLSFVKGVVDSDDLPLNISREMLQQNKILKVIRKNLVKKCIEMFFEIAENKDDYKKFYDAFSKNIKLGIHEDSQNRAKLADLLRYYSTKSGDEMTSLKDYVTRMKEGQKDIYYITGESKKAVENSPFLERLKKKGYEVLFMVDAIDEYAVGQLKEYDGKKLVSATKEGLKLDEESEDEKKKREEKKKSFENLCKTIKEILGDKVEKVVVSDRIVDSPCCLVTGEYGWTANMERIMKAQALRDNSMSAYMSSKKTMEINPDNGIMEALRKRAEVDKNDKSVKDLVLLLYETALLTSGFSLDDPNTFAGRIHRMLKLGLSIDEDETAVDDVDMPSLEEETNEESKMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R6A1</accession>
    <name>A0A0D2R6A1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G0631001</name>
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        <name type="common">Peruvian cotton</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <reaction evidence="5">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
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        </reaction>
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    <comment type="similarity">
        <text evidence="1">Belongs to the UDPGP type 1 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
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        </submittedName>
    </protein>
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        <lineage>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB47698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_008G037300"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33372:SF10">
        <property type="entry name" value="OS03G0137300 PROTEIN"/>
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    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
    <sequence length="288" mass="30805" checksum="089C58BA57280913" modified="2015-04-29" version="1">MAATTLSVRSNRLTPGTPIPRPPVNLPTQTYPSFKPTKTEPWRATTIVHSRRILAARAGSRADDSAPFEMSVENALKLLGVSENASFDDILRAKNSIVASIKDDQEAIAQVEAAYDMLLMRSLTQRRAGKVVDRSIRYADVKSVNPSGVGSMPRWVQTTVKNLPVSVVAPVTSELGIQAGVYGALMVLTYVNGASTSSVVPYTGPDVPGLILASSFGASLYFMTRKNVKLGKATLITIGGLVAGAVVGSAVENWLQVDIVPLLGIHSPATVVSEFILFSQFLVSMYLR</sequence>
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    <accession>A0A0D2R990</accession>
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        <recommendedName>
            <fullName evidence="3">MPBQ/MBSQ family SAM-binding methyltransferase profile domain-containing protein</fullName>
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    </protein>
    <gene>
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        <name evidence="5" type="ORF">Gorai_016062</name>
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        <lineage>
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            <taxon>malvids</taxon>
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    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. MPBQ/MBSQ MT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R990"/>
    <dbReference type="STRING" id="29730.A0A0D2R990"/>
    <dbReference type="Gramene" id="KJB28409">
        <property type="protein sequence ID" value="KJB28409"/>
        <property type="gene ID" value="B456_005G046100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796688"/>
    <dbReference type="eggNOG" id="KOG1540">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051741">
        <property type="term" value="F:2-methyl-6-phytyl-1,4-benzoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000095">
        <property type="entry name" value="2-methyl-6-phytyl-1,4-hydroquinone methyltransferase, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044649">
        <property type="entry name" value="MPBQ/MSBQ_MT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031164">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516:SF11">
        <property type="entry name" value="2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44516">
        <property type="entry name" value="2-METHYL-6-PHYTYL-1,4-HYDROQUINONE METHYLTRANSFERASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51734">
        <property type="entry name" value="SAM_MPBQ_MSBQ_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="MPBQ/MBSQ family SAM-binding methyltransferase profile" evidence="3">
        <location>
            <begin position="68"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif I" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif II" evidence="1">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAM motif III" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB28409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0585281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="340" mass="38493" checksum="2BBDB2C129A062F0" modified="2015-04-29" version="1">MASSMLNGTEYLKLINGVTPSGLGFLGSNFHFKGLSQKGLLCYTKNQKTRILAPRCSLSSSRPASQPRFIQHKKEAFWFYRFLSIVYDHIINPGHWTEDMRDEALEPADLYSRNMTVVDVGGGTGFTTLGIVKHVDAKNVTILDQSPHQLAKAKQKEPLKECKIIEGDAEDLPFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGKACVIGPVYPTFWLSRFFADMWMLFPKEEEYIEWFEKAGFKDVKLKRIGPKWYRGVRRHGLIMGCSVTGVKPLSGDSPLKLGPKAEDVKKPVNPFVFLFRFIIGAIAATYFVLVPIYMWLKDQIVPKGQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RBW9</accession>
    <name>A0A0D2RBW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G095200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GEM family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RBW9"/>
    <dbReference type="STRING" id="29730.A0A0D2RBW9"/>
    <dbReference type="Gramene" id="KJB29334">
        <property type="protein sequence ID" value="KJB29334"/>
        <property type="gene ID" value="B456_005G095200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUDB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSGHEEN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13222">
        <property type="entry name" value="PH-GRAM_GEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037848">
        <property type="entry name" value="GEM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31969">
        <property type="entry name" value="GEM-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRAM" evidence="3">
        <location>
            <begin position="160"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB29334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="282" mass="30522" checksum="C4E4217979303C49" modified="2015-04-29" version="1">MRQPASDPNNIPEAKQSTTSSDSTLVPPLSSDYAPYPKLDPKDVAPPPENWTNVSMGSQSQPNQGPATFSGSAATTMPAESNPYVSPAPVRSSSVKTDKMGAVKEVLGKLGKKAAEDTKKAKEIAGNMWQHLKTGPSFADAAVGRIAQGTKVLAEGGYDKIFRTTFETAPEEQLLKTYACYLSTSAGPVMGVLYLSSQKLAFCSDNPLSYQVGAQTQWSYYKVAIPLHQLRAVNPSTSKANPAEKYIQIISVDNHEFWFMGFVHYDSAVKNLQRPLQPARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RD34</accession>
    <name>A0A0D2RD34_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Chlorophyll a-b binding protein, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_002G263900</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 21">The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The LHC complex consists of chlorophyll a-b binding proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast thylakoid membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 21">Belongs to the light-harvesting chlorophyll a/b-binding (LHC) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RD34"/>
    <dbReference type="STRING" id="29730.A0A0D2RD34"/>
    <dbReference type="Gramene" id="KJB17070">
        <property type="protein sequence ID" value="KJB17070"/>
        <property type="gene ID" value="B456_002G263900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786561"/>
    <dbReference type="eggNOG" id="ENOG502QRH9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERPLWYP"/>
    <dbReference type="OrthoDB" id="423598at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009522">
        <property type="term" value="C:photosystem I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016168">
        <property type="term" value="F:chlorophyll binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009765">
        <property type="term" value="P:photosynthesis, light harvesting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3460.10:FF:000003">
        <property type="entry name" value="Chlorophyll a-b binding protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3460.10">
        <property type="entry name" value="Chlorophyll a/b binding protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001344">
        <property type="entry name" value="Chloro_AB-bd_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022796">
        <property type="entry name" value="Chloroa_b-bind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21649">
        <property type="entry name" value="CHLOROPHYLL A/B BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00504">
        <property type="entry name" value="Chloroa_b-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103511">
        <property type="entry name" value="Chlorophyll a-b binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 20 21" id="KW-0148">Chlorophyll</keyword>
    <keyword evidence="6 21" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="16 21" id="KW-0157">Chromophore</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 21" id="KW-0602">Photosynthesis</keyword>
    <keyword evidence="12 21" id="KW-0603">Photosystem I</keyword>
    <keyword evidence="19 21" id="KW-0604">Photosystem II</keyword>
    <keyword evidence="9 21" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17 21" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" evidence="20">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>chlorophyll b</name>
            <dbReference type="ChEBI" id="CHEBI:61721"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Mg</name>
            <dbReference type="ChEBI" id="CHEBI:25107"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>chlorophyll a</name>
            <dbReference type="ChEBI" id="CHEBI:58416"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR601344-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU363080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB17070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="285" mass="31144" checksum="E2AAC025AD7B86F1" modified="2015-04-29" version="1">MAAITNAAATSSFMGTRFPDVYTSSGRFVARFGFGGKKAAPKKVSKRTPDRPLWYPGAVAPDWLDGSLVGDYGFDPFGLGKPAEYLQYDLDSLDQNLAKNSAGEIIGTRTEVADVKATPFQPYSEVFGLQRFRECELIHGRWAMLATLGALTVEWLTGVTWQDAGKVELVEGSSYLGQPLPFSMTTLIWIEVLVIGFIEFQRNAELDPEKRLYPGGKYFDPLGLAADPEKKATLQLAEIKHARLAMVAFLGFAVQAAATGKGPLNNWATHLSDPLHTTIIDTFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDC7</accession>
    <name>A0A0D2RDC7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G120600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDC7"/>
    <dbReference type="STRING" id="29730.A0A0D2RDC7"/>
    <dbReference type="Gramene" id="KJB29839">
        <property type="protein sequence ID" value="KJB29839"/>
        <property type="gene ID" value="B456_005G120600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QU0Z">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ISNYGEM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF54">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26410">
        <property type="entry name" value="GH5_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250108" description="mannan endo-1,4-beta-mannosidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="59"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF26410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB29839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="429" mass="48325" checksum="CBE5961799A02385" modified="2015-04-29" version="1">MDTCKRCFLLSLAFLMVFFEKLGTNVVFGFNGNYKHHSPHFSTSQGIYDMEDVEDDGWQMVETKGNQFIVNSQPFYVNGFNTYWLMVMAADQSTRGKVSEVFQQASSVGLTVCRTWAFNDGQWRALQKSPSVYDEEVFKALDFVVSEAKKYKIRLMLSLVNNWDAYGGKPQYVKWGKAAGLNLTSDDEFFSHPTLRSYYKAHVKAVVNRVNTFTNITYKDDPTIFAWELMNEPRCTSDPSGDTLQSWIAEMAVYVKSLDAKHLVEIGVEGFYGPSAPARAQFNPNSISQTISDAHLQFTTTWMEAHIEDAEKYLGMPVIFAEFGVSSKDPGYNSSFRDALISTVYKTVLNSTKKGGSGAGSLLWQLFPEGMDNMDDGYAIVLAKSPSTLNLISLHSSKLAIFNSMCSWKCHWGCKKKNALETIIYHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDI7</accession>
    <name>A0A0D2RDI7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="12">2.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_008G113600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="12"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDI7"/>
    <dbReference type="STRING" id="29730.A0A0D2RDI7"/>
    <dbReference type="Gramene" id="KJB49293">
        <property type="protein sequence ID" value="KJB49293"/>
        <property type="gene ID" value="B456_008G113600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB49297">
        <property type="protein sequence ID" value="KJB49297"/>
        <property type="gene ID" value="B456_008G113600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763792"/>
    <dbReference type="eggNOG" id="KOG0692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YLWAAEV"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000004">
        <property type="entry name" value="3-phosphoshikimate 1-carboxyvinyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000009">
        <property type="entry name" value="3-phosphoshikimate 1-carboxyvinyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Enolpyruvate transferase" evidence="13">
        <location>
            <begin position="85"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB49293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="521" mass="55524" checksum="57E0D846369F5858" modified="2015-04-29" version="1">MATQVGKIYNGTQKTCVLPNVSKTQNPKHVPFVSFKSNLNGKTSSWGLVVKNNGKFGSIKVRSLKVSASTATAEKPSRASEIVLQPINEISGTVKLPGSKSLSNRILLLAALSEGTTVVENLLNSDDVHHMLVALGKLGLYVKHDGEKKQAIVEGCGGQFPVGKGEGQEIELFLGNAGTAMRPLTAAITAAGGNSSYVLDGVPRMRERPIGDLVTGLKQLGADVDCTLGTNCPPVRIEGKGGLPGGKVKLSGSISSQYLTALLMAAPLALGDVEIEIIDKLISIPYVEMTIKLMKRFGVTVEHTDSWDRFFIRGGQKYMSPGNAYVEGDASSASYFLAGAAVTGGTVTVEGCGTSSLQGDVKFAEVLEMMGAKVTWTKNSVTVTGPPRNSSGRKHLRAIDVNMNKMPDVAMTLAVVALYADGPTAIRDVASWRVKETERMIAICTELRKLGATVEEGPDYCVITPPEKLNVTAIDTYDDHRMAMAFSLAACAEVPVTIKDPGCTRKTFPDYFEVLARVTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDN7</accession>
    <name>A0A0D2RDN7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trigger factor ribosome-binding bacterial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G124300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDN7"/>
    <dbReference type="STRING" id="29730.A0A0D2RDN7"/>
    <dbReference type="Gramene" id="KJB29934">
        <property type="protein sequence ID" value="KJB29934"/>
        <property type="gene ID" value="B456_005G124300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560:SF5">
        <property type="entry name" value="OS09G0515400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="TRIGGER FACTOR CHAPERONE AND PEPTIDYL-PROLYL CIS/TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16590" checksum="7436800B4A63C012" modified="2015-04-29" version="1">MEVAVGKTLWLGLNPKIISCKQEKGIFVSNTFCRRACFPPRIRYRTLKFHGRKRHEYLRTAHAISSDVEDVGVSSQFEDFTVTPCSTEECRKLKIRVEVSGAKTRAIFNEVFDKMVADAQPIPGFRRVKGGKNYMVLYENGNGLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2REU0</accession>
    <name>A0A0D2REU0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_005G031100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2REU0"/>
    <dbReference type="STRING" id="29730.A0A0D2REU0"/>
    <dbReference type="Gramene" id="KJB28156">
        <property type="protein sequence ID" value="KJB28156"/>
        <property type="gene ID" value="B456_005G031100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28157">
        <property type="protein sequence ID" value="KJB28157"/>
        <property type="gene ID" value="B456_005G031100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28158">
        <property type="protein sequence ID" value="KJB28158"/>
        <property type="gene ID" value="B456_005G031100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796518"/>
    <dbReference type="eggNOG" id="ENOG502QTEN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECFCQPN"/>
    <dbReference type="OrthoDB" id="1882547at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF14">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB28156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="519" mass="58909" checksum="C5596537EF610F74" modified="2015-04-29" version="1">MRRPGLHRQHGKQGGGSKGIYAKLTVVVVVLLICTFSVLFLATISGNRGSLEPSEINVEELWESAKSGGWRPSSAPRSDWPPPPKETNGYLRVRCNGGLNQQRSAICNAVLAARIMNATLVLPELDANSFWHDDSGFQGIYDVEHFIQTLKYDVRIVESIPEIHKNGKTKKIKAHQIRPPRDAPISWYTTVALKKMKEHGAIYLTPFSHRLAEEIDNAEYQRLRCRVNYHALRFKPNIMRLSESIVDKLRAQGHFMSIHLRFEMDMLAFAGCFDIFSPEEQSILKKYRKENFAEKRLVYNERRAIGKCPLTPEEVGLVLRAVGFDNSTRIYLAAGELFGGERFMKPFRDLFPCLENHSSVDSSEELVANTRGLLGSAVDYMVCLLSDIFMPTYDGPSNFANNLLGHRLYYGFRTTIRPDRKGLAPIFIDRENGQTAGFEQAVRRVMLKTNFGGPHKRVPPESFYTNSWPECFCQMSPSNPADKCPPDNVLEILESQLENEVNRDLEASMETNSTRRTEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKK3</accession>
    <name>A0A0D2RKK3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G130400</name>
        <name evidence="3" type="ORF">B456_003G112500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKK3"/>
    <dbReference type="STRING" id="29730.A0A0D2RKK3"/>
    <dbReference type="Gramene" id="KJB09230">
        <property type="protein sequence ID" value="KJB09230"/>
        <property type="gene ID" value="B456_001G130400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB19650">
        <property type="protein sequence ID" value="KJB19650"/>
        <property type="gene ID" value="B456_003G112500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1588">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MSPFDGT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF109">
        <property type="entry name" value="OS01G0886300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB09230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB19650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="17537" checksum="0C1368335B062460" modified="2015-04-29" version="1">MMGERILPGSYFQYPPPGFPSVSPHRPSSIPTDLERVYIRGKGSVKDSVKEEKLKDKPGFEHLNEPLHVLVEAELPKDVINSRLDYVVAILENLLKPVDESLDNYKKQQLRELALLNGTLREESPRMSPTMSPSMSPFNGTGMKRANYFSQKPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RN18</accession>
    <name>A0A0D2RN18_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G005100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RN18"/>
    <dbReference type="STRING" id="29730.A0A0D2RN18"/>
    <dbReference type="Gramene" id="KJB33274">
        <property type="protein sequence ID" value="KJB33274"/>
        <property type="gene ID" value="B456_006G005100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798047"/>
    <dbReference type="eggNOG" id="ENOG502RZK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1848784at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31719">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31719:SF179">
        <property type="entry name" value="OS08G0148400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="5">
        <location>
            <begin position="27"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="260" mass="30580" checksum="D6E3BA46EE97D653" modified="2015-04-29" version="1">MSNNFELGTTENINNNEEDDEELLNSFPAGYRFKPRDDELVLFYLKPKLLNLRLPPNRIRDVELYHYNPQQLIEKYGSYGEEEWYFFTPREKKYRNGLRPNRTAGDGYWKATGADKILRSESHEIGYRKALVFYKGKPPKGEKTDWMMHEFRLKDPPAKLSQDEMRLDDWILCKIYQKSDKSTKNSALISDNPQGVVSFEYGSDEFGEMDDNLYCDYLMFDHNPSLLLDDNFCDYYDPSLIPMAMVEQGRMDSPDKKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RN87</accession>
    <name>A0A0D2RN87_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 19">Pyruvate kinase</fullName>
            <ecNumber evidence="7 19">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_003G154200</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 19">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="7 19"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RN87"/>
    <dbReference type="STRING" id="29730.A0A0D2RN87"/>
    <dbReference type="Gramene" id="KJB20555">
        <property type="protein sequence ID" value="KJB20555"/>
        <property type="gene ID" value="B456_003G154200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789078"/>
    <dbReference type="eggNOG" id="KOG2323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HQGRYDR"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000005">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16 19" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="12 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="14 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="20">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="21">
        <location>
            <begin position="376"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB20555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="506" mass="54978" checksum="389D5CDA41C4A219" modified="2015-04-29" version="1">MEINNHHEGGFEMEKKPKTKIVCTLGPASRSVPMIEKLLRAGMNVARFNFSHGSHAYHQETLDNLRAAMLSTGILCAVMLDTKGPEIRTGFLKDGKIQLKQGQEITITTDYSIKGDETLISMSYKKLAEDVKPGMVILCADGTISFTVLSCDKQNGLVHCRCENSAVLGERKNVNLPGVVVDLPTLTEKDKEDILEWGVPNQIDMIALSFVRKGSDLVEVRKLLGKHAKNILLMSKVENQEGVANFDDILTNSDAFMVARGDLGMEIPIEKIFLAQKVMIYKCNIQGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCVMLSGETAAGAYPELAVQTMAKICVEAESTLDYGDVFKRIMEHSPVPMSPLESLASSAVRTANSAKASLILVLTRGGSTAKLVAKYRPGMPILSMVVPEIQTDSFDWSCSDEAPARHSLVYRGLIPVLYAGSARASHEETTEEALEFAIQHAKAKGLCQNGDSIVALHRIGTASVIKILTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVZ7</accession>
    <name>A0A0D2RVZ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G090300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVZ7"/>
    <dbReference type="SMR" id="A0A0D2RVZ7"/>
    <dbReference type="STRING" id="29730.A0A0D2RVZ7"/>
    <dbReference type="Gramene" id="KJB23290">
        <property type="protein sequence ID" value="KJB23290"/>
        <property type="gene ID" value="B456_004G090300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB23291">
        <property type="protein sequence ID" value="KJB23291"/>
        <property type="gene ID" value="B456_004G090300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790830"/>
    <dbReference type="eggNOG" id="KOG3434">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QEDGILN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000002">
        <property type="entry name" value="60S ribosomal protein L22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF36">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB23290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14008" checksum="64AFD49C1E8D042A" modified="2015-04-29" version="1">MSRGAAAGAKGKKKGASFTIDCAKPVEDKIMDIASLEKFLQERIKVGGKAGALGDSVTVTRDKTRITVTSDSNFSKRYLKYLTKKYLKKHNVRDWLRVIASNKDRNVYELRYFNIAENEGEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3E8</accession>
    <name>A0A0D2S3E8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G148700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3E8"/>
    <dbReference type="STRING" id="29730.A0A0D2S3E8"/>
    <dbReference type="Gramene" id="KJB77647">
        <property type="protein sequence ID" value="KJB77647"/>
        <property type="gene ID" value="B456_012G148700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779262"/>
    <dbReference type="eggNOG" id="KOG2049">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIQEQRC"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF129">
        <property type="entry name" value="PUMILIO HOMOLOG 15-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="PUM-HD" evidence="8">
        <location>
            <begin position="177"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="385"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="6">
        <location>
            <begin position="421"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB77647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="526" mass="60125" checksum="7E02BADCEFC30458" modified="2015-04-29" version="1">MERNSYTQGRQIAFMGDPTEENQEFPFDDSSSTGFSNPNFSQGLQGHHDVRVFGFQQSSLDDRFSQLNLNDIENPTRIVGSDFGPAPIGLLHENSFNGRHVLRSLPSQNMVVDRSPNYSPSTLIEHNVFDFDTNTQRRTPPFERPYNLCDPMRSVNGFGSTLMRPSMHDHQHQPFYSPPPRQLPRENSSYYYIPPLRELKAGDICTVAKDRDRCLALQKKLDNEVLTRGEIDMIFMEVKDHLHELMVHRFANYLIQKLFKAINNEQRTQLLLLLIRSHQRFFQVCTNLYGSRTIQKFIEIINIQEQRCILLSALKPIAITLAKDSNGHHIFEPCLKKFSSEETMHLMDGIIQHCVDIAINKSGCCALQQCLTHANDEVSEHFLVRIVANALFLSEDKYGNYVVQFVLQMGLPWVTSMIIGQLQGSFVSLCFSKYGSNVVEKCMKESEEQLSARVIMEILNDPDYLKVFGHDYGNFVIQSALLASKGHANLGIHNAIHCLIRKHYSFLQSSPFGRRILSAASKCRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S4P3</accession>
    <name>A0A0D2S4P3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_012G175200</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="2">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the 20S core complex of the 26S proteasome. The 26S proteasome is composed of a core protease (CP), known as the 20S proteasome, capped at one or both ends by the 19S regulatory particle (RP/PA700). The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB78067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S4P3"/>
    <dbReference type="STRING" id="29730.A0A0D2S4P3"/>
    <dbReference type="Gramene" id="KJB78067">
        <property type="protein sequence ID" value="KJB78067"/>
        <property type="gene ID" value="B456_012G175200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779337"/>
    <dbReference type="eggNOG" id="KOG0175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQIEMAH"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000034">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="9" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB78067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="29477" checksum="F017009AC563C1F3" modified="2015-04-29" version="1">MKLDTTGMESAAPVWGSHNELVDGFSAAPSFELPNTTDFDGFQKEAIQMVKPAKGTTTLAFIFKEGVMVAADSRASMGGYISSQSVKKIIEINPYMLGTMAGGAADCQFWHRNLGTKCRLHELANKRRISVTGASKLLANILYSYRGMGLSVGTMIAGWDETGPGLYYVDNEGGRLKGMRFSVGSGSPYAYGVLDNGYRYDMSVEEAAELARRAIYHATFRDGASGGVASVYYVGPNGWKKLSGDDVGELHYRYYPVMPSTVEQEMVEVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SD51</accession>
    <name>A0A0D2SD51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">B456_009G340400</name>
        <name evidence="28" type="ORF">Gorai_013270</name>
    </gene>
    <organism evidence="27 29">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 29" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="28 30" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">8</strain>
            <tissue evidence="28">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="28" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="28">8</strain>
            <tissue evidence="28">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SD51"/>
    <dbReference type="Gramene" id="KJB61093">
        <property type="protein sequence ID" value="KJB61093"/>
        <property type="gene ID" value="B456_009G340400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766062"/>
    <dbReference type="eggNOG" id="ENOG502RMH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HICRKYE"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000432">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000288">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF88">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11 25" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="25">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220358" description="non-specific serine/threonine protein kinase" evidence="25">
        <location>
            <begin position="24"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="654"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="712"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="959"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="971"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="748"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KJB61093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="MBA0596451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1039" mass="114364" checksum="20A128C1A5F1A7B1" modified="2015-04-29" version="1">MEYVQFLVLLFSLFQIHINSCMCQHMGELDSTTDKAALLSFKLQLNDPLNSLSGWTRNSTSHCTWFGISCTSKGSRVESLQLSSLGLVGPLPPSLSNLTSLRTLNLSHNLFHGQFQLEFSKLSHLRHIDLRNNSINGTLPVALSHCLNLKTLRLQGNKFSGNLPPQLGNFQRLSILSISINNLTGSIPPTFGNLSSLTYLALARNMLIGEIPSEFGQLKKLQHIQLSENHLSGQIPSSIFNISSLVFLSVTHNNLSGSLPIPNDNHRFQALPNVREVYLALNWFEGILPAYLSNASNIECLDLSRNRFHGPIPLFGNMRKLIMLDLGQNLFSSSTARNVHFIDSLSNCTQLEYLRINSNRLSGEFPSVANLSTNIQHLCISDNFLTGGFPQGMDKFQNLISLSLEMNSLTGDIPRSIAKLGNLQNFLVHQNIFSGEIPEIFANLTRVSSIVMRNNQFSGKIPTSLGNCQQLQTLDLSWNRLNGSVPEEVFKLSGLNYLVLEHNMLSGPLPSDVGNLKQLQVIDVSDNNLFGTLTSSISGCSSLLYLNMSRNNLSGEIPSSLANILPLEVLDLSSNNLSGPIPQELANLKSLKFLNLSSNYLEGDVPTGNIFSNLSSSSIRGNDDLCSADKEIARNLQLHQCKTKGRQSNHLIKILVPISGATLFICLVFCFVWALISRRKKNRVKGSQSLLSLKGLPPLISYSDIQIATSHFTAENLLGKGGFGSVYKGTFNTGDDGASINNVTFAVKVLDLQQTKAVQSFLAECEALRNLRHRNLVKIITSCSSIDHKRDEFKALVYEFMPNGNLDKWLYPEDEESGFCLTLMQRLNISIDVASAMDYLHNDCDPAVVHCDLKPANVLLDENMAAHVGDFGLARFLCQRPSQRENSTMGLKGSVGYIAPEYGLGSKASTSGDAYSFGVLVLEMFIAKKPTDEMFKEGLSLNKFASAVDRNQVFETVDPRILKNHGGSEQSSSNPSSSNDSSNGGTSSTDSDHICRKYEECLAAVIRVGLSCAAQSPKDRLPMRETLTKLHDIKKIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SEX4</accession>
    <name>A0A0D2SEX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G158100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SEX4"/>
    <dbReference type="Gramene" id="KJB81717">
        <property type="protein sequence ID" value="KJB81717"/>
        <property type="gene ID" value="B456_013G158100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783027"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LETFRMM"/>
    <dbReference type="OrthoDB" id="1902591at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF344">
        <property type="entry name" value="OS07G0636900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="334"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="435"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="536"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="637"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="852"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB81717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="944" mass="105172" checksum="069FB1E48B1B16FB" modified="2015-04-29" version="1">MLIQSLVFRCLSTRKNRLVIEFPRRLLFASFQFVSSFTAHVATEEINPSLKVPLFKEKTKLEGSKRLKLYSKILHDCASKGSLSSAKAVHGKIIKNGIDPDLHLWNSLVNAYAKRGVFGYACKVLDRMPERDVVSWAALFSGLVNEGYGYYVLDLYCSMKKDGVLPNGHCLVTALKACSLSLDLFFGTLLHGEGVKVGVLLDVFVGSSLVDLYAKCGQMELAERVFLFMDKKNVVSWNALLNGYALKGDAGKILNLFQGMTESELRCSKFTLSNVLKSCTYLVNLTWGLIAHSLVIKTGCEHDEFVGCCLLDMYSKCGLAEDTLKVFKRIQEPNIVAWSAMIDCLDEQGQIQEAAELFSLMRCKGVSPNQHTFASIAGVAANLGDRLYCEGVHACIFKHGFESEIILSNALIAMYMKIRSVQNGWRVFKEMSSWNSASWNSLLSGSHNGKTCDRGPSIFHKMLAEGFKPDICTFTSILRSCSNLLNIKFGHQVHAHIIKNGLKDNNLVGTSLIDLYAKNGFLADAELLFTQLIERDLFSWTALIAGYAQSDCSEKAIKCFNHMQRQGVTPNNFTLATCLSSCSNMAMLENGQLLHSMAIKAGNSGDMFVSSSIVDMYANCGCIEEAEAAFQGMVSTDTVSWNTMLFGYLQHRQGLKVLETFRMMLDKGLEPDEVTFIAVLSACSYMGFVNEGKEYFDSLTNVFGIVPTIKHCACMIDILGRAGKFNEVESFIKDMKVTSNPLIWETVLGACRMHGNDKLGESAAEKLFELNPGIASHYILLANIFAAKGRWEDVRRVRALMTHCGVKKEPGCSWVMVNGQVHIFRSTDGFHPKHGEIYIKLKELVEKSILAGYVPKTDHILNDVSDDEKLEQLFHHNERLALAFALISINPVKTIRIFKNLHICEDCHDFMKLVSGVIKQEIVVRDANCFHHFKSGICSCQDYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SIF5</accession>
    <name>A0A0D2SIF5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G168100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SIF5"/>
    <dbReference type="STRING" id="29730.A0A0D2SIF5"/>
    <dbReference type="Gramene" id="KJB30925">
        <property type="protein sequence ID" value="KJB30925"/>
        <property type="gene ID" value="B456_005G168100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794515"/>
    <dbReference type="eggNOG" id="ENOG502QT42">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMEFQKA"/>
    <dbReference type="OrthoDB" id="1056333at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010547">
        <property type="entry name" value="TOM20_imprt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32409:SF7">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32409">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06552">
        <property type="entry name" value="TOM20_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB30925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22036" checksum="12AB0B91E1607D1F" modified="2015-04-29" version="1">MEFSQADFDRLLVAEHTRKTSEVNYAKDPLDAENLTKWGGALLELAQFQTVSDAKQMINDAISKLDEALMINPSKHETLWCMGNALSTTAFMTTDSDEAKVSFDKAAQFFQRAVDADPGNELYQKSLEVAAKAPELHMDFQKAAASQQGMGGASSASSTSTAAKKKKSSDLKYDIFGWIILAVGIFAWVGMAKSHLPPPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMX4</accession>
    <name>A0A0D2SMX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G051100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMX4"/>
    <dbReference type="STRING" id="29730.A0A0D2SMX4"/>
    <dbReference type="MEROPS" id="M20.A05"/>
    <dbReference type="Gramene" id="KJB64483">
        <property type="protein sequence ID" value="KJB64483"/>
        <property type="gene ID" value="B456_010G051100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772726"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGFFVWM"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009850">
        <property type="term" value="P:auxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009694">
        <property type="term" value="P:jasmonic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08017">
        <property type="entry name" value="M20_IAA_Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044757">
        <property type="entry name" value="ILR1-like_Hyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF62">
        <property type="entry name" value="IAA-AMINO ACID HYDROLASE ILR1-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="6">
        <location>
            <begin position="266"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB64483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="475" mass="52015" checksum="C161923A36EA62F3" modified="2015-04-29" version="1">MYSLKSYVLVVSLIFIPFFANNFLVFVNSITSSSGNQYTTFFNAISSSTNPKASLNSGKNQTTSSLISSSFCDVWDVTCSEEVLGLAQEPDNVEWIKGLRRKIHENPELAFEEYETSKLVRSELDRMDIEYRYPLAKTGIRAWVGTGGPPFVAIRADMDALPIQEAVEWEHKSKVAGKMHACGHDAHVAMLVGAAKILKNREHLLKGTVIVIFQPAEEAGNGAKRMIGDGALENVEAIFAVHVSHEHPTGIIGSRPGPLLAGCGFFRAVFSGRKGLAGSPHHSVDPILAASAAVISLQGIVSRESNPLDSQVVSVTSFNGGNNLDMIPETVVIGGTFRAFSNASFYNLLQRIEEVIVEQANVFRCWATVDFFEKESTIYPPTVNDNRMYEHVKKVATDLLGPPNFRVVPPMMGAEDFSFYSQVVPAAFYYIGVRNETLGSTHTGHSPYFMIDEDVLPIGAAVHATIAERYLNEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQG8</accession>
    <name>A0A0D2SQG8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="7">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_007G366900</name>
        <name evidence="19" type="ORF">Gorai_020121</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the CCR4-NOT complex, at least composed of CRR4 and CAF1 proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the CAF1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="7"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQG8"/>
    <dbReference type="STRING" id="29730.A0A0D2SQG8"/>
    <dbReference type="Gramene" id="KJB46419">
        <property type="protein sequence ID" value="KJB46419"/>
        <property type="gene ID" value="B456_007G366900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761724"/>
    <dbReference type="eggNOG" id="KOG0304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YVTFHSA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="14" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB46419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0591444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="277" mass="31168" checksum="36E7EBBF4058833C" modified="2015-04-29" version="1">MSNKPRESVVIRSVWSENLDSEFEIIRSIIDVFPIISMDTEFPGVVVRSEGAGGCHRSRRIDATENYQSLKANVDILKLIQIGLTLSDADGNLPNLGTENRYIWEFNFKDFDVGNDVHAPDSVELLRRQGIDFEKNLELGIELVRFAELMMSSGLVLNDAVTWVTFHCAYDFGYLVKCLTGGLLPDQLTEFLELVRVFFGDRIYDVKHLMKFCAGLHGGLDRASTDLGVKRAIGKSHQAGSDSLLTLHAWLKIKERYFANGDPIEKYANVLYGLEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQI3</accession>
    <name>A0A0D2SQI3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SOSEKI DIX-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G241300</name>
        <name evidence="12" type="ORF">Gorai_019423</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Homodimer. Forms long polymer filaments with other SOKs proteins polymers (e.g. SOK1, SOK2, SOK3 and SOK4) crucial for polar localization and biological activity. Binds to ANGUSTIFOLIA (AN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SOSEKI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQI3"/>
    <dbReference type="STRING" id="29730.A0A0D2SQI3"/>
    <dbReference type="Gramene" id="KJB44231">
        <property type="protein sequence ID" value="KJB44231"/>
        <property type="gene ID" value="B456_007G241300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804250"/>
    <dbReference type="eggNOG" id="ENOG502QVHU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1731358at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051302">
        <property type="term" value="P:regulation of cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000067">
        <property type="term" value="P:regulation of root morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090708">
        <property type="term" value="P:specification of plant organ axis polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010369">
        <property type="entry name" value="SOK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048351">
        <property type="entry name" value="SOK_DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021182">
        <property type="entry name" value="SOK_magnoliopsida"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083:SF18">
        <property type="entry name" value="PROTEIN SOSEKI 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31083">
        <property type="entry name" value="UPSTREAM OF FLC PROTEIN (DUF966)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06136">
        <property type="entry name" value="SOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031043">
        <property type="entry name" value="UCP031043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SOSEKI DIX-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="376"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB44231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0590729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="421" mass="47759" checksum="5F8A654D81A4F8DB" modified="2015-04-29" version="1">MNARNRRPRESSPGRAKVCILQQPKAVKPIRKVQVVYYLTRNGQLEHPHYMEVTHLVNQPLRLRDVTERLTALRGKAMPSLYSWSCKRSYKNGYVWNDLADNDIIPPSDGAEYVLKGSELVDGCSEVLQKMQISNKGPHFQEPNLHPKQKSQTFALTRHRGPQEPDRTAYEEQEFDDGDEEEEEEYELDEEKTCYTSSTTPHSRCSRGVSTDELEYQETNIQGPQKPISDTPKQDSSILSENQNQNQSKNNTSKRFEDGDPVTNVSTSGRNSSVLLQLIACGNLAVNKAKNMPTVVKQPVVPNTVVKKSENLHRGVLCKTAIKAAEDDQMISCMSENPRFGNLQAQEKEYFSGSIVESMNSENRVVGDQPMLKRSNSYNEERRCKAGLSEPVEEEKKDKAVKGNCIPRKKLPKQTRKMRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQW5</accession>
    <name>A0A0D2SQW5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_006G020700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Binds to the translation initiation factors TIF3E1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQW5"/>
    <dbReference type="STRING" id="29730.A0A0D2SQW5"/>
    <dbReference type="Gramene" id="KJB33600">
        <property type="protein sequence ID" value="KJB33600"/>
        <property type="gene ID" value="B456_006G020700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798221"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSKCELW"/>
    <dbReference type="OrthoDB" id="1557636at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF47">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="197" mass="23068" checksum="9FFC09F628B6A981" modified="2015-04-29" version="1">MVHVSFYRNYGKTFKKPRRPYEKERLDAELRLVGEYGLRCKRELWRVQYALSRIRNAARDLLTLDEKNPRRIFEGEALLRRMNRYGLLDESQNKLDYVLALTVENFLERRLQTLVFKTGMAKSIHHARVLIRQRHIRVGRQVVNIPSFMVRVDSQKHIDFSLTSPFGGGRPGRVKRKNQRAAAKKAAGGDGDEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUN8</accession>
    <name>A0A0D2SUN8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoside diphosphate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_010G174500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUN8"/>
    <dbReference type="STRING" id="29730.A0A0D2SUN8"/>
    <dbReference type="Gramene" id="KJB67093">
        <property type="protein sequence ID" value="KJB67093"/>
        <property type="gene ID" value="B456_010G174500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771502"/>
    <dbReference type="eggNOG" id="KOG0888">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNAISYW"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46161:SF3">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE DDB_G0292928-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252042" description="Nucleoside diphosphate kinase-like domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="11">
        <location>
            <begin position="29"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB67093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="177" mass="20060" checksum="DC463EE817FCFC9A" modified="2015-04-29" version="1">MTQFLTRFFSFSMLVIVLRCYSSTGRGEKERTLGIIKPDGLSGNYTNRIKQVILESGFEISKEMVIQLDEQDAANFYAEHSSKIFFTDLIRYMTSGPVLVMILEKEDAVAHWRNLIGPTDAGKAKITHPHSIRAMCGIDLEKNCIHGSDSHQSAEREIAFFFKEAPSDEAVRKHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVZ1</accession>
    <name>A0A0D2SVZ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G117000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVZ1"/>
    <dbReference type="STRING" id="29730.A0A0D2SVZ1"/>
    <dbReference type="Gramene" id="KJB35485">
        <property type="protein sequence ID" value="KJB35485"/>
        <property type="gene ID" value="B456_006G117000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799276"/>
    <dbReference type="eggNOG" id="KOG1510">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="90" mass="9861" checksum="4046A35BF70E9336" modified="2015-04-29" version="1">MSAALVKAAKQFDALVAALPPSEGGEKAQLRRIAELQVENDTVGQELQKQLEAAVKELKQVQELFSQAADNCLNLKKLEFISLNNPSFHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZE4</accession>
    <name>A0A0D2SZE4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent helicase BRM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G121100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2SZE4"/>
    <dbReference type="Gramene" id="KJB49474">
        <property type="protein sequence ID" value="KJB49474"/>
        <property type="gene ID" value="B456_008G121100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763869"/>
    <dbReference type="eggNOG" id="KOG0386">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNMGSNQ"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000100">
        <property type="entry name" value="ATP-dependent helicase BRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000017">
        <property type="entry name" value="ATP-dependent helicase BRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000762">
        <property type="entry name" value="ATP-dependent helicase BRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000038">
        <property type="entry name" value="Brahma1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="9">
        <location>
            <begin position="490"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="1343"/>
            <end position="1520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="457"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="557"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1620"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2072"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="50"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="312"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="557"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="577"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="578"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1639"/>
            <end position="1648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1673"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1700"/>
            <end position="1713"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="1717"/>
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        <location>
            <begin position="1742"/>
            <end position="1755"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1786"/>
            <end position="1801"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1812"/>
            <end position="1823"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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            <begin position="1825"/>
            <end position="1836"/>
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    </feature>
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        <location>
            <begin position="1844"/>
            <end position="1862"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1863"/>
            <end position="1881"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1920"/>
            <end position="1929"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2072"/>
            <end position="2084"/>
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    </feature>
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        <location>
            <begin position="2103"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2137"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2181"/>
            <end position="2198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="2205"/>
            <end position="2228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB49474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2250" mass="252233" checksum="44D4C9BBEF0337A7" modified="2015-04-29" version="1">MHSGSGGGGGPSRNPSVGPVGRAASTSSAASPSSSSSAVSTPHLGFDSVQQQPQQQQQQQSQKQQHQIASRQSLQQQLLRKPEGNEANLAYQASGLQGLMGGSNFPSSPGSMQPPQMSRRFFDLPQQHASAQDSQNRSQGVEQQMASSAQQAYYQFAYQASQQQKALLAQQQAKMAMLGPASFKDQDMRTGNIKMQELISMQAANQAQASSSKNASEQLGCAEKQIEQGSRSASEHKPPAQATVIGQLMPGNVLRAMQTQQAPQTVQNMGNNQVAMAAQLQAWALERNIDLLQPANANLMAQLIPLMQSRMAAQQKTNERNMGTQSSPVPVSKPQITSPSVPSESSPRGNSSNDISGMSGFAKTRPMAPPNTFGSTSSVGVINSANNVSMQQLAIHGLDNQELPRQSVGHGNGMPPMHPPQVSANVSQSIDPSLPAKNSSGGIETVQMQHTKHFNRSSLQPAAPGNDGGSVNNVPSQGGASTQMPQQRFGFTKQQLHVLKAQILAFRRLKKGEGTLPQELLRAIVPPPLVVQQMQLPPLGGNNQDRDGGKNIEDQAKQVESKEKVAQAEQSTKGQNITKDEAYVGDDRATESTAHMQGASAMAKDPSTLPAGKEEQQSSVFSVKSDQEVERGLPKAPVRSDFSADRGKAVSPQVAASDGGQVKKPMQANSAPQLKDPASARKYHGPLFDFPFFTRKHESYGSAMPNSNNNLTLAYDVKDLLFEEGMEVLSKKRSENLRKIGNLLAVNMETKRIRPDLVLRLQIEEKKLRLKDLQARLRDEVDQQQQEIMAMPDRPYRKFVRLCERQRIELARHVQVTQKALREKQLKSIFQWRKKLLEAHWAIRDARTARNRGVAKYHERMLREFSKRKDDDRNKRMEALKNNDVERYREMLIEQQTNIPGDAAERYEVLSSFLTQTEEYLQKLGSKITAAKNQQEVADAANAAAVAARLQGLSEEEVRVAAACAGEEVMIRNRFMEMNAPREGSSVSKYYNLAHAVNEKIIRQPSMLRAGTLRDYQLVGLQWMLSLYNNKLNGILADEMGLGKTVQVMALIAYLMEFKGNYGPHLIIVPNAVLVNWKSELHNWLPSVSCIYYVGGKEQRSKLFSQEVLAMKFNVLVTTYEFIMYDRSKLSKIDWKYIIIDEAQRMKDRESVLARDLDRYRCQRRLLLTGTPLQNDLKELWSLLNLLLPEVFDNRKAFHDWFSQPFQREPTHNAEDDWLETEKKVIIIHRLHQILEPFMLRRRVEDVEGSLPPKVSIVLKCRMSAIQSAIYDWIKSTGTLRVDPEDEKRKVQKNPIYQAKVYKTLNNRCMELRKTCNHPLLNYPYFNDFSKDFLVRSCGKLWILDRILIKLQRTGHRVLLFSTMTKLLDILEEYLQWRRLVYRRIDGTTSLEDRESAIVDFNSPHSECFIFLLSIRAAGRGLNLQSADTVVIYDPDPNPKNEEQAVARAHRIGQTREVKVIYMEAVVDKISSQQKEDELRSGGTVDFEDDFAGKDRYMGSIESLIRNNIQQYKIDMADEVINAGRFDQRTTHEERRMTLETLLHDEERYQETVHDVPSLHQVNRMIARSEEEVELFDQMDEELDWTEEMTCHEQVPKWLRASVREVNAAVATLSKKPSKNILFTAGGGTESKETDTERKRGRPKKKIPSYKEIDETGEFSEASSDERNGYSGNEEEGEIGEFEDDEFSGAVGAPPVNNDQSEEDGALGDDGYEDAQASEHIRNNHILEEGGSSGSSLDSRRPTQMVSPISPQKFGSLSALDARPGSAARRLSDDLEEGEIAGSGDSHMDHQQSESWNHDRDEGEDEQVVQPKIKRKRSIRVRPRQTVERVEEKSATEEPLLQRGGSSLLSFQLDQKYQSQLRTDTERKPTRERNAFKHDPNDSSSKSRRNLPPRQIANTSKLHASVKPGRMNSMSAPSEDAGKPSRESWDSKLVNTCGSSNFGAKMSDVIQRKCKNVISKLQRRIDKEGQHIVPLLTDLWKRIENSGYTGGSGSNQLDFRKIDQRVDRLEYSGVMELVSDVQLVLKSAMHFYGFSHEVKSEAKKVHDLFFDLLKIVFTDTDFQEARNSLSFFSPASTSTSGPSSRQVAVGKRQKQMTDVESDSGLTQKSLQQRGPTHTGEETRIRVQLPQKELRLGSGSTREPYQQGDSLPTHPGELVTCKKKRKDREKSMVKPRTGSVGPISSPSIVRNIRSPTAGSVSKDVRPTQQTTHQPWPNQPAHLSNGSSGSVGWANPVKKLRTDTGKRRPSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZU7</accession>
    <name>A0A0D2SZU7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="17">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_006G178900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 23">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="17"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SZU7"/>
    <dbReference type="STRING" id="29730.A0A0D2SZU7"/>
    <dbReference type="Gramene" id="KJB36840">
        <property type="protein sequence ID" value="KJB36840"/>
        <property type="gene ID" value="B456_006G178900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0543">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000008">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000029">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000039">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000052">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF8">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0007">Acetylation</keyword>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="15 17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="17" id="KW-0697">Rotamase</keyword>
    <keyword evidence="11 18" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="20">
        <location>
            <begin position="51"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="20">
        <location>
            <begin position="175"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="20">
        <location>
            <begin position="292"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="18">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB36840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="625" mass="70522" checksum="7424CA7A4A134835" modified="2015-04-29" version="1">MASEEDTEQSYVPQKKKSESEDDKRRKKIVPGSLMKALMRPGGGESNPSDGDQIIYHCTVRTLDGVVVESTRSEHGGKGIPIRNVLGKSKMILGLLEGIPTMLKGEVAMFKMMPQMHYGEEDCPVPAPSSFPKEDDLHFEIELIDFSKAKVVSDDLGVLKKVIDEGQGWESPREPYEVKAWISAKTGDGKLIMSHTEGEPYFFTFGKCEVPKGLEMGIGTMTRKEKAVVYVTNQYLTPSPLLPMIEGYEEVHFEVELVHFIQVRDMLGDGRLIKRRLHDGKGDFPMDCPLHDSLLRVHYKGMLLNEEKTVFYDTRVDNQGEPLEFSSGEGMVPEGFEMCVRLMLPGEIALVTCPPDYAYDRFSRPPSVPEGAHVQWEIELLGFEMPKDWTGLNFQEIMDEAEKIRVTGNRLFKSGKFELAKAKYEKVVLREFNHVNPQTDEEGKVFLDTRNSLHLNVAACFLKMGECRKSIDACNKVLDATPVHAKALYRRGMAYMAAGDFEEARSDFQMMIKVDKSSEPDATAALAKLKKQEQEVERKARKQFKGLFDKKPGEIAEVQVEDRAGREITGENQKNDLSAPLLERDDSQHFNEADGGQYGMGWFYSLWPPGRRTFSALGLDRCTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T198</accession>
    <name>A0A0D2T198_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Strictosidine synthase conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_008G061100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the strictosidine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T198"/>
    <dbReference type="STRING" id="29730.A0A0D2T198"/>
    <dbReference type="Gramene" id="KJB48271">
        <property type="protein sequence ID" value="KJB48271"/>
        <property type="gene ID" value="B456_008G061100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1520">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVRRCSK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018119">
        <property type="entry name" value="Strictosidine_synth_cons-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426:SF93">
        <property type="entry name" value="PROTEIN STRICTOSIDINE SYNTHASE-LIKE 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10426">
        <property type="entry name" value="STRICTOSIDINE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20067">
        <property type="entry name" value="SSL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03088">
        <property type="entry name" value="Str_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Strictosidine synthase conserved region" evidence="5">
        <location>
            <begin position="131"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB48271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="334" mass="37030" checksum="5FD14893E3EB959B" modified="2015-04-29" version="1" fragment="single">SPTLQCLTQILIRGMPSPAPHPKKRLCPFPLLLSTLFPLLAAVLVYQLDPFDPAPLPIHELGQAAMSVSLRNDRMLQGAELVGAGELLGLEDIAYDSKSHLIYTGCQDGRIKRVRLHHADSAVEKWVNTHDGVDVADNGMIYFTDASYKYSMEDSVWDVLEGKPHGRLMSFDPVTRKTRVLVTHLYFANGVAVSPRQNSLILCETTMRRCRKYYIEGNKQGEQEKFVDNLTGLPDNIKYDGEGHYWIALATGNSVVLDLALRYAFIRKAMGLMEKYIGGLSKGKNAGVLVVDLEGKPVTSAIKIGNRLYCGSFVYPHITSLDLNQHPARSTVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2C6</accession>
    <name>A0A0D2T2C6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G218400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2C6"/>
    <dbReference type="STRING" id="29730.A0A0D2T2C6"/>
    <dbReference type="Gramene" id="KJB37735">
        <property type="protein sequence ID" value="KJB37735"/>
        <property type="gene ID" value="B456_006G218400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB37736">
        <property type="protein sequence ID" value="KJB37736"/>
        <property type="gene ID" value="B456_006G218400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800331"/>
    <dbReference type="eggNOG" id="ENOG502QUVH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PYCISEN"/>
    <dbReference type="OrthoDB" id="591557at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="74"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB37735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="445" mass="51127" checksum="75879FB58A425829" modified="2015-04-29" version="1">MLHYSVTVIRTNKFREMENQEPTPTQPNQRLGSPSQELPSTSSNEQTQKRNRPESPQRKSDDSAQSPKRSRNGSLPPQSFPQEIIFEILLNLPVQSLLRFRCVSKPWKSLIADNFFIKKHLKRAQNDPEFSKKRVLINTSSIQTGSSIKSCSLKSIFEDPNVNTTEIEYPSKKASRYDWIVGSCNGLICIAIREDTVLLLNPTLRVSKRLPDLGFKKRRGCYTVYGFGFDASGDDYKVVRVFCYQSKGFEDGYESIVRVYSMRTNCWRRIQDFPFGVPFSEAGKHVDGTLNWAVLSRQYRDFSCTIVSLDLAQETYKEVTQPCYGNGAGERILGVLDGCLCVLCSYGRLYAEVWVMKEYGKRESWTKLVTIPYTPIPGYEMFLTPLSVSKSGEILLRFEVNMLLYNPEKNMFRIPMFPYDAFSYIDQQEVYEESLVSPTVVNQHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2P0</accession>
    <name>A0A0D2T2P0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_011G051000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2P0"/>
    <dbReference type="STRING" id="29730.A0A0D2T2P0"/>
    <dbReference type="Gramene" id="KJB69948">
        <property type="protein sequence ID" value="KJB69948"/>
        <property type="gene ID" value="B456_011G051000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0206">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFIIMIC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000023">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF157">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="960"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="992"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1042"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1083"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1112"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="928"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="590"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="637"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="660"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="694"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="775"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="776"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <feature type="binding site" evidence="13">
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="882"/>
        </location>
        <ligand>
            <name>ATP</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="902"/>
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        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="905"/>
        </location>
        <ligand>
            <name>ATP</name>
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    </feature>
    <feature type="binding site" evidence="13">
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        <ligand>
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    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB69948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1236" mass="141192" checksum="46DF6A19B1CA7E1C" modified="2015-04-29" version="1" fragment="single">MVAASSRKRKGKIRWSKLYSFAACFRPLTSKERLAARELIGQPGFSRVVFCNEPHLHKRKPYKYPYNYISTTKYNVLTFLPRALFEQFRRVANFYFLLAAIFSLFSLAPFSRASLIAPLVFVVGISMLKEAVEDWHRFFQDLDVNNRTVKTHISNGVFVDKLWKELRVGDVVKVNKGEYFPSDLLLLSSGNEDGVCYVETMNLDGETNLKIKRCLEASLCLNEDEEFSKFKATVHCEDPNPNLYTFVGNIEFEKESYPLSPSQLLLRDSKLRNTDYIYGVVIFSGHDTKAVRNSTRSPSKRSRIERKMDHIIYILFSMLVLVSLVSSFGSLLYLRQDMVDWWYLQLPDDNKVNDLDDSNSEKYDDRFFNPSKPVQSAGLQFIRALVLYGYLIPISLYVSIEVVKVLQTMLINKDIELYDDVTCKSVQARTSNLNEELGQVEMILSDKTGTLTCNQMEFRKCSIAGVSYGGDITEVDLAASMRMNADFEPFEFSIDETDGATRSFEPFEFSVSSFSAQNGNARLTKTEEPVIKGFNFRDDRLTNENWIHGSNLFDITMFFRVMALCHTGIPLEDDNHKTDKLSYEAESPEEVSFLIASQEFGFQFCRRTQSLMVLREFDPSSMKEVEREYKLLNLLEFSSSRKRMSVIVSNEDGQNFLLCKGADSIIFDRLADNGRAYEQATTMHLSSYAEDGLRTLAFAYRTIEAAEYESWNTIFTQAKATIGPEREELLEQASETIEKDLILLGVVAVEDKLQKGVPECIDKLAQAGLKIWLLTGDKRETAINIGFACSLLRQDMKQFHLSLSRDAESNNQVKDMKEDILQQIESSYKMVCEERNKEAPFGLVIDGKALEIALRGDVKDEFLQLAVNCASVICCRVSPKQKALITRLVKQYTGKTTLAIGDGANDVGMIQEADIGVGISGMEGMQAVMASDFSLPQFRFLERLLIVHGHWCYQRISKMVLYFVYKNVAFGLTLFYYELYTSFSGEVLYDDWYMTMFNVMLTSLPVIALGVLEQDVSSDICLQFPALYQQGPRNVHFSWSRIIGWILNGVVSSLVIFLANIYILSPTAMRENGFVADIDSLGATTYTCIIWTVNCQIALITSHFTWIQHLSIWGSILLWYIFLLVYGALPPNFSGNAFQVLVEGIGPAPLYWMITVLVVVVSLLPYFIHIVIQRSYFPMDDHIIQEMEQCYKKYDVRDNEMWVREQRNSQRSTRIGFSARVDAKILSFNQQLQQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8T2</accession>
    <name>A0A0D2T8T2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G193000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T8T2"/>
    <dbReference type="STRING" id="29730.A0A0D2T8T2"/>
    <dbReference type="Gramene" id="KJB50916">
        <property type="protein sequence ID" value="KJB50916"/>
        <property type="gene ID" value="B456_008G193000"/>
    </dbReference>
    <dbReference type="OMA" id="PSIMFDP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038821">
        <property type="entry name" value="CLE45-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36726">
        <property type="entry name" value="CLAVATA3/ESR (CLE)-RELATED PROTEIN 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36726:SF5">
        <property type="entry name" value="CLAVATA3_ESR (CLE) GENE FAMILY MEMBER MTCLE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="96" mass="10438" checksum="2DB4307AC134C62C" modified="2015-04-29" version="1">MGFSVNTRGFILVSCIALLVFQTEIVSAMRGIDLALKWDKGLSPLVENSRILRAVGSVDSLQTPPSLAPAPSIMFDPNRSNKRSVKKGSDPIHNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TAW9</accession>
    <name>A0A0D2TAW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G226200</name>
        <name evidence="11" type="ORF">Gorai_010221</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TAW9"/>
    <dbReference type="STRING" id="29730.A0A0D2TAW9"/>
    <dbReference type="Gramene" id="KJB51636">
        <property type="protein sequence ID" value="KJB51636"/>
        <property type="gene ID" value="B456_008G226200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB51638">
        <property type="protein sequence ID" value="KJB51638"/>
        <property type="gene ID" value="B456_008G226200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765003"/>
    <dbReference type="eggNOG" id="KOG0706">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QAQHDMS"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000012">
        <property type="entry name" value="ADP-ribosylation factor GTPase-activating protein AGD10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="9">
        <location>
            <begin position="11"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="153"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB51636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0593268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="403" mass="43827" checksum="2DF262E98EA3151E" modified="2015-04-29" version="1">MESSDNLSDKNAVFRKLKTKSDNKMCFDCNAKNPTWASVTYGIFLCIDCSAVHRSLGVHVSFVRSTNLDSWSPEQLKMMIYGGNNRAQVFFKQHGWTDGGKIESKYTSRAAELYRQLLAKEVTKSMEEEVGMPLFPVASQSSKASNGFFDSKIDETPKESSLGGLGKPEVSATQKASHTVVTSTVKKPLGAKKTGKTGGLGARKLTSKPSENLYDQKPEEPVAPVTSSTKNTVPIASSFPSRFEYVENGQSSEFNSGGPQVVSHIAPPKSSSFIADFGMDRGFQKNSVSNSPKVQVQETDEARRKFLNAKSISSAQFFGDQTRAADNDAQVTLQKFSGSTAISSADLFGKGADHDLTASDLISRFSFQAQHDMSNLKNIAGETGKKLSSFASTFMSDLQDRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TIZ6</accession>
    <name>A0A0D2TIZ6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G053400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TIZ6"/>
    <dbReference type="Gramene" id="KJB75718">
        <property type="protein sequence ID" value="KJB75718"/>
        <property type="gene ID" value="B456_012G053400"/>
    </dbReference>
    <dbReference type="OMA" id="SSTLYCC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB75718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="104" mass="12258" checksum="EA5762FB06391651" modified="2015-04-29" version="1">MILRRLYVLQVFSAESSTLYCCVHLIVVYLIIFDINKAGGYICLCFLSPKRYQLVLKVRFSLFQAYSVKGRKGEMNSMQIYRRGTWHGDMMYIKIFKDDLNKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKX5</accession>
    <name>A0A0D2TKX5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G084000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family. CC-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKX5"/>
    <dbReference type="SMR" id="A0A0D2TKX5"/>
    <dbReference type="STRING" id="29730.A0A0D2TKX5"/>
    <dbReference type="Gramene" id="KJB76353">
        <property type="protein sequence ID" value="KJB76353"/>
        <property type="gene ID" value="B456_012G084000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779208"/>
    <dbReference type="eggNOG" id="KOG1752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AAWSYYM"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000028">
        <property type="entry name" value="Glutaredoxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011905">
        <property type="entry name" value="GlrX-like_pln_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02189">
        <property type="entry name" value="GlrX-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10168">
        <property type="entry name" value="GLUTAREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="5">
        <location>
            <begin position="35"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB76353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="125" mass="13551" checksum="276289BCA66AE9B9" modified="2015-04-29" version="1">MHCQTGSWGSYVPTTRTTVGDPLERIERLASENAVVIFSISSCCMCHAIKRLFCGMGVNPTVYELDQDPRGKDMEKALMRLLGSSPAVPVVFIGGKLVGTMDRVMASHINGTLVPLLKQAGALWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TNH1</accession>
    <name>A0A0D2TNH1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G289700</name>
        <name evidence="13" type="ORF">Gorai_019737</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15133"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutamate + NADP(+) + H2O = 2-oxoglutarate + NH4(+) + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11612"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.4.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 10">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TNH1"/>
    <dbReference type="STRING" id="29730.A0A0D2TNH1"/>
    <dbReference type="Gramene" id="KJB45110">
        <property type="protein sequence ID" value="KJB45110"/>
        <property type="gene ID" value="B456_007G289700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804769"/>
    <dbReference type="eggNOG" id="KOG2250">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AHECEVL"/>
    <dbReference type="OrthoDB" id="6718861at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004352">
        <property type="term" value="F:glutamate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000003">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000212">
        <property type="entry name" value="Glutamate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val/Trp_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033524">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11606:SF29">
        <property type="entry name" value="GLUTAMATE DEHYDROGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00074">
        <property type="entry name" value="GLFV_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal" evidence="11">
        <location>
            <begin position="178"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB45110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0591049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="411" mass="44720" checksum="94E490FA0538EB4E" modified="2015-04-29" version="1">MNALVATNRNFKLAARLLGLDSKLEKSLLIPFREIKVECTIPKDDGTLASFVGFRVQHDNARGPMKGGIRYHPEVEHDEVNALAQLMTWKTAVANIPYGGAKGGIGCDPRDLSISELERLTRVFTQKIHDLIGIHADVPAPDMGTGPQTMAWMLDEYSKFHGYSPAVVTGKPIDLGGSLGRDAATGRGVLFATEALLNEHGKAISGKKIVIQGFGNVGSWAARLIHEKGGKIVAVSDITGAIKNSKGIDIPRLLNHVKENKGVKGFEGADSLDPESILVEDCDILIPAALGGIINRENANEIKAKFIIEAANHPTDPEADEILSKKGVIILPDIYANSGGVTVSYFEWVQNIQGFLWDEEKVNNELKTYMTKAFKDVKKMCQVHNCDLRMGAFTLGVNRVARATVMRGWEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQD9</accession>
    <name>A0A0D2TQD9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alcohol dehydrogenase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G3219002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQD9"/>
    <dbReference type="STRING" id="29730.A0A0D2TQD9"/>
    <dbReference type="Gramene" id="KJB45700">
        <property type="protein sequence ID" value="KJB45700"/>
        <property type="gene ID" value="B456_007G3219002"/>
    </dbReference>
    <dbReference type="OMA" id="CQVEGWV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000141">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB45700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="11775" checksum="1AD344EC34D13B01" modified="2015-04-29" version="1" fragment="single">MAKSPEEEHPVKTFGWAARDPSGHLSPFIFSRRVTGEEDVRFKVLYCGICHSDLHSIKNEWGSSNYPMVPGHEIVGEVTEVGSKVEKVKVGDKVGVGCMVGACHSCDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSH6</accession>
    <name>A0A0D2TSH6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G368000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 81 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSH6"/>
    <dbReference type="STRING" id="29730.A0A0D2TSH6"/>
    <dbReference type="Gramene" id="KJB46425">
        <property type="protein sequence ID" value="KJB46425"/>
        <property type="gene ID" value="B456_007G368000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TRENRVW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005200">
        <property type="entry name" value="Endo-beta-glucanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040720">
        <property type="entry name" value="GH81_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983">
        <property type="entry name" value="ENDO-1,3(4)-BETA-GLUCANASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31983:SF0">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17652">
        <property type="entry name" value="Glyco_hydro81C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52008">
        <property type="entry name" value="GH81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="9">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 81 C-terminal" evidence="9">
        <location>
            <begin position="92"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB46425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="311" mass="34877" checksum="5B271199EE3657DD" modified="2015-04-29" version="1">MDVDALDSSAITTKSVYFYSKLIARAARLALIAEEVCFLDVIPAIRKFLKDTIEPWLDGTFNGNGFLYESKWGGIVSKQGSRDSEADFGFGIDPAWGRRYKPQAYSLVAGFMNLGSRSNSNYPRMRCFDFYKLHSWAGGLAEFADGRNQESTSEAVNGLNSAALMGLAYGDTHLVATGSTLTAHVIQAAQTWWHVKEGDNLYGEEFTRENRVWSWFAPPDWRECRLGIQLLPLLPISEILFSDIEYTRQLANWTLPALGRDVVGDGWKGFVYALEAIYDEESALEKIRNLSGLDDGNSLTNLLWWVHSRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSX4</accession>
    <name>A0A0D2TSX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G013200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="3">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSX4"/>
    <dbReference type="STRING" id="29730.A0A0D2TSX4"/>
    <dbReference type="Gramene" id="KJB78643">
        <property type="protein sequence ID" value="KJB78643"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB78644">
        <property type="protein sequence ID" value="KJB78644"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB78645">
        <property type="protein sequence ID" value="KJB78645"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB78646">
        <property type="protein sequence ID" value="KJB78646"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB78648">
        <property type="protein sequence ID" value="KJB78648"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB78649">
        <property type="protein sequence ID" value="KJB78649"/>
        <property type="gene ID" value="B456_013G013200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783749"/>
    <dbReference type="eggNOG" id="ENOG502QS6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEDESWH"/>
    <dbReference type="OrthoDB" id="696085at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF212">
        <property type="entry name" value="CALMODULIN BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4005" evidence="4">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB78643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="385" mass="44135" checksum="293244425F87898E" modified="2015-04-29" version="1">MGKKRSWFSWVKKIFASNAQPKTQKKSRRWRWIFGKLKLKQCRPALPAIPQQKSLCQATEDQRKHALNLAIATAAAAEVAVAAARAAAEVVRLANASNHFSNFTTKDRNRAAIKIQTAFRAHLARKALRALKGLVLLQAIIRGQVTRRRAMKNMKCLQSGTEMYPGIKEKVICQDTRRNQSLVHKDQLQVKDIIEHEYYSRRNWNDSVFSKEDAEAVWLRRQEAMAKRERMKKYSYSHRERVNSYMLDESVHVKETGRNSFLEAEANSEGTRRERMMILKHNVASNSSTWEVHGLQGLNSPYLFPRRSFCRVQNQNPAGNDSSVPSSTVFPTYMAATESAKAKVRSMSTPRQRLGLSDTCFDHNMPYKGGLSLWSTYNGETFKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TT75</accession>
    <name>A0A0D2TT75_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase-like plant mobile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G018300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TT75"/>
    <dbReference type="STRING" id="29730.A0A0D2TT75"/>
    <dbReference type="Gramene" id="KJB78773">
        <property type="protein sequence ID" value="KJB78773"/>
        <property type="gene ID" value="B456_013G018300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3035">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1110:FF:000002">
        <property type="entry name" value="isoamyl acetate-hydrolyzing esterase 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019557">
        <property type="entry name" value="AminoTfrase-like_pln_mobile"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF9">
        <property type="entry name" value="GDSL ESTERASE_LIPASE CPRD49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10536">
        <property type="entry name" value="PMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase-like plant mobile" evidence="4">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB78773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="403" mass="45594" checksum="2D149B1611844200" modified="2015-04-29" version="1">MSRGYKLDLTLISTLVERWRPKTYTFYLPCNECTITLEDVSLQIGLSVDGPAITGSTIVPGKVGLYKSLLGKVPDKFEGGRILMNWLKDNFNELPEDLEDRTEERGDLGQKPDIIIVSNLISIDVLRDCQRETSKRKGVQREEKRREMVGPVRPQFVLFGSSIVQLSFSNGGWGAILADVYARKADILLRGYFGWNSRRAIQVLDHVFPKDASTQPELIITYFGGNDSMGAHPSGLGPHVPLPEYIENMKQIVNYLKGLSDSTRLIFLTSPPVNEERVNKYASEHFSHLVRTNELCQTYADACVKLCQELDVKVVNLFTAFQQRENWMTDCFTDGVHLSAEGSKIVVAEILKVLKEAEWKPSLHWKSMPTEFAEDSPYDIVGADGKTTLNPSEWTFHQEIQWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTP0</accession>
    <name>A0A0D2TTP0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G026200</name>
        <name evidence="12" type="ORF">Gorai_002218</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probable carboxypeptidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0602021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTP0"/>
    <dbReference type="SMR" id="A0A0D2TTP0"/>
    <dbReference type="MEROPS" id="S10.A23"/>
    <dbReference type="Gramene" id="KJB78938">
        <property type="protein sequence ID" value="KJB78938"/>
        <property type="gene ID" value="B456_013G026200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782924"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DTSCRIH"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000003">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000013">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF198">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033755257" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB78938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0602021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="470" mass="53521" checksum="780E0D4A64B4ACC1" modified="2015-04-29" version="1">MGQSRFIDFLFVLLTCFTCFSSSFGDQNLDKITELPGQPKNVDFNQYSGYVTVNEEAGRALFYWFIESPLNRRPETRPLILWLNGGPGCSSVAYGAAEEIGPFRIRPDGKTLYSNPYAWNKLANTLFLESPAGVGFSYTNTTSDLYTSGDKRTAEDAYVFLVNWLERFPQYKYRDFYIAGESYAGHYVPQLAQIVYERNKGVQNPVINFKGFMVGNAVTDDYHDFVGTFEYWWTHGLISDSTYRNLQVACDLGSATHPSSECTTALEVAEAEQGNIDPYSIFTQPCADTTSLRRNLRGHYPWMSRAFDPCTERYSKEYFNRPEVQKALHANVTGIPYQWETCSDVVGYNWTDSPLSMLPIYQELIAAGIRIWVYSGDTDAVVPVTATRYSIDALKLPTINKWHPWYDNGKVGGWSQEYKGLTFVTVTGAGHEVPLHRPRQAFILFRSFLENKSMPSYLYSLSAVNKWKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TUJ0</accession>
    <name>A0A0D2TUJ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial adenine nucleotide transporter BTL3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G237100</name>
        <name evidence="14" type="ORF">Gorai_012575</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probable mitochondrial adenylate carrier that catalyzes the transport of ATP, ADP and AMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TUJ0"/>
    <dbReference type="STRING" id="29730.A0A0D2TUJ0"/>
    <dbReference type="Gramene" id="KJB59066">
        <property type="protein sequence ID" value="KJB59066"/>
        <property type="gene ID" value="B456_009G237100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59067">
        <property type="protein sequence ID" value="KJB59067"/>
        <property type="gene ID" value="B456_009G237100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770313"/>
    <dbReference type="eggNOG" id="KOG0752">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQYMIRT"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000098">
        <property type="entry name" value="Mitochondrial substrate carrier family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="217"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="331"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0595717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46223" checksum="F55028CA25E7E459" modified="2015-04-29" version="1">MPKFHLQFKNSLPDYQPYLPFPSNSNLLVPGGLFIDPCFPSSLLDLVSPFKGSPPSKNTACVSRRQKRESVAVQDLFFLSVSLSSDGLVSEHKECQLQNELNKKNKGAVAQVKQKVRVTRRGAVNTTKHLWAGAIAAMVSRTFVAPLERLKLEYIVRGEQRNIFELVKKIALTQGLLGFWKGNLINVLRTAPFKAVNFYAYDTYRKQLLRLSGNEETTNSERFIAGAAAGITATVLCLPLDTIRTKLVAPGGEALGGVIGAFRHMIQTEGFFSLYRGLVPSIVSMAPSAAVFYSVYDMLKSAYLHSPEGRKRIQNMRQMGQDLNALDQLELGPVRTLLYGAIAGACAEVATYPFEVVRRQLQLQVQASKMGALATGLKIVEQGGIPALYAGLIPSLLQVLPSASISYFVYEFMKIVLKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZ09</accession>
    <name>A0A0D2TZ09_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_008G074300</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZ09"/>
    <dbReference type="SMR" id="A0A0D2TZ09"/>
    <dbReference type="STRING" id="29730.A0A0D2TZ09"/>
    <dbReference type="Gramene" id="KJB48530">
        <property type="protein sequence ID" value="KJB48530"/>
        <property type="gene ID" value="B456_008G074300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763350"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001864">
        <property type="entry name" value="Calcium-dependent protein kinase SK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000085">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000101">
        <property type="entry name" value="CDPK-related kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001294">
        <property type="entry name" value="CDPK-related kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="163"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="467"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB48530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="610" mass="68013" checksum="2049321888102383" modified="2015-04-29" version="1">MGLCTSKPSPNPSDSTNASINTRNNDIYRKPNSVSASPLPDGVNSKEDQGKQGEEEKESSNPNNEGKKSPFFPFYSPSPAHYLFSKKSPARSSTNSTPKRFFRRPFPPPSPAKHIRAVLARRHGSVKPNEAAIPEGSDAEAAGATGTGLDKSFGFSKHFGSKYELGDEVGRGHFGYTCTAKFKKGELKGQQVAVKVIPKAKMTTAIAIEDVRREVKILRALSGHSNLVQFYDAYEDHDNVYIVMELCEGGELLDRILSRGGKYTEDDAKAVMIQILNVVAFCHLQGVVHRDLKPENFLFTSKDENSQLKAIDFGLSDFVKPDERLNDIVGSAYYVAPEVLHRSYSTEADVWSIGVIAYILLCGSRPFWARTESGIFRAVLKADPSFDEAPWPSLSSEARDFVKRLLNKDPRKRLTAAQALSHPWIKKYNDVKVPLDILIFKLVKAYLRSSSFRKAALRALSKTLTVDELFYLKEQFALLEPNKNGTISLENIKAALMKNATDAMKDARIPEFLASLNALQYRRMDFDEFCAAALTVHQLEALDRWEQHARCAYEIFEKEGNRPIVIEELASELGLSPSVPVHAVLHDWIRHTDGKLSFLGFVKLLHGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U635</accession>
    <name>A0A0D2U635_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_008G1956002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin-like family. Class-II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U635"/>
    <dbReference type="STRING" id="29730.A0A0D2U635"/>
    <dbReference type="Gramene" id="KJB50963">
        <property type="protein sequence ID" value="KJB50963"/>
        <property type="gene ID" value="B456_008G1956002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50964">
        <property type="protein sequence ID" value="KJB50964"/>
        <property type="gene ID" value="B456_008G1956002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50965">
        <property type="protein sequence ID" value="KJB50965"/>
        <property type="gene ID" value="B456_008G1956002"/>
    </dbReference>
    <dbReference type="OMA" id="SNMTLMH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000020">
        <property type="entry name" value="Formin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051144">
        <property type="entry name" value="Formin_homology_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733">
        <property type="entry name" value="FORMIN-J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45733:SF10">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 15A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="98"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="511"/>
        </location>
    </feature>
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        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="94"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="481"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB50965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="511" mass="55466" checksum="5E44BAE022D6A666" modified="2015-04-29" version="1" fragment="single">PPPPPMRGAPAPPPPPMRGAPAPPPPPMRGAPAPPPPPMRGAPPPPPGGAPPPPPPPGGRAPGPPAPPGAPRGAPPPPPLGARAADVRGRGRGLSRPGAAAAPRRSSLKPLHWSKVTRAIQGSLWEELQRYGEPQIAPEFDVSEIETLFSAVVPKPADSGGKSGGQRKSAGSKPDKVHLIDLRRANNTEIMLTKVKMPLSDMMAAVLAMDDTVLDVDQVENLIKFCPTKEEMELLKGYTGDKENLGKCEQYFLELMKVPRVESKLRVFSFKIQFGSQISEFRKSLNTVNSACNEVRNSVKLKEIMKKILYLGNTLNQGTARGSAIGFKLDSLLKLTDTRASTSKMTLMHYLCKVLAAKAPALLDFHLEFVSLEAATKIQLKSLAEEMQAIIKGLEKLKQELVASENDGPVSEVFRKTLKEFISVAETEVVSLTNLYSMVGRNADALALYFGEDPARCPFEQVTATLLNFVRLFRKAHEENVKQAELDKKKAEKEAEMEKAKEANHKKKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U654</accession>
    <name>A0A0D2U654_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Remorin C-terminal domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G196300</name>
        <name evidence="6" type="ORF">Gorai_009990</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the remorin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U654"/>
    <dbReference type="STRING" id="29730.A0A0D2U654"/>
    <dbReference type="Gramene" id="KJB50979">
        <property type="protein sequence ID" value="KJB50979"/>
        <property type="gene ID" value="B456_008G196300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50980">
        <property type="protein sequence ID" value="KJB50980"/>
        <property type="gene ID" value="B456_008G196300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764687"/>
    <dbReference type="eggNOG" id="ENOG502S23G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETKADSW"/>
    <dbReference type="OrthoDB" id="775261at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005516">
        <property type="entry name" value="Remorin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471:SF5">
        <property type="entry name" value="GB|AAD39278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471">
        <property type="entry name" value="OS02G0116800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03763">
        <property type="entry name" value="Remorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Remorin C-terminal" evidence="4">
        <location>
            <begin position="117"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB50980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0593031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="224" mass="25444" checksum="A9977742EADBBC8D" modified="2015-04-29" version="1">MNDDYNTELAVGVAAAAYIINSLVEDEARHRIKIRRSAQDTITGVRSSDRVTMRYSSKEIETAGETSSRKLMEKDNRSQESSLPRSKKGGSSSGRPVIMEAGDRSRKGNSSQLNVGETKADAWEKAEMEKLNKRCENMKASILAWENEKKLRAKVKMDKRKKELERRIKINQQLYQTKISRIDHIGGGAKAEVDEKRRHEELKIKEKARKIRASGKVPVSCFCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7N0</accession>
    <name>A0A0D2U7N0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aldehyde dehydrogenase 1</fullName>
            <ecNumber evidence="6">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_010G069600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>octanal + NADP(+) + H2O = octanoate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:59904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17935"/>
            <dbReference type="ChEBI" id="CHEBI:25646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:59905"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="6"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7N0"/>
    <dbReference type="SMR" id="A0A0D2U7N0"/>
    <dbReference type="STRING" id="29730.A0A0D2U7N0"/>
    <dbReference type="Gramene" id="KJB64879">
        <property type="protein sequence ID" value="KJB64879"/>
        <property type="gene ID" value="B456_010G069600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773894"/>
    <dbReference type="eggNOG" id="KOG2450">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSNTFNK"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000011">
        <property type="entry name" value="ALD5p Mitochondrial aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000065">
        <property type="entry name" value="Aldehyde dehydrogenase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00050461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB64879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="497" mass="53951" checksum="AFC07AEC659ED3EC" modified="2015-04-29" version="1">MGSHCESSVKIPPIKFTKLFINGNFVDSISGKTFDTIDPRTGEVITKVSLGDREDVDLAVKAARHAFDYGPWPRMSGSERGRMMMKLADLIEENVEEIAALDAVNGGKLFTLCKAIDIPGAARTLRYYAGAADKIHGTVLKMSKGLQGYTLREPIGVVGSIIPWNFPTTMFFMKAAPALAAGCTLVVKPAEQTPLSALYYAHLAKLAGIPDGVLNVVNGFGETAGAAISAHMDIDKVTFTGSTEVGRKIMAAAAASNLKPVSLELGGKSPLLIFDDADIDQAADIAFRGMFYNKGEICVASSRVYVQEGIYEKLVKKLVEKAKATVVGDPFDPQVNQGPQTDKKQFEKILSYIEHGKREGATLLTGGKHVGQKGYYIEPTIFTDVNEDMIITKEEIFGPVMSLMKFKTMEEAIKRANNTTYGLASGIITKNLNVANTVSRSIRAGVVWINCYTAFDVDCPYGGYKMSGFGRDFGLDALNQYLQIKSVVTPIHDSPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB71</accession>
    <name>A0A0D2UB71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phenylalanine ammonia-lyase</fullName>
            <ecNumber evidence="6 13">4.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_010G086000</name>
        <name evidence="15" type="ORF">Gorai_007425</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is a key enzyme of plant metabolism catalyzing the first reaction in the biosynthesis from L-phenylalanine of a wide variety of natural products based on the phenylpropane skeleton.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>L-phenylalanine = (E)-cinnamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21384"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="EC" id="4.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Phenylpropanoid metabolism; trans-cinnamate biosynthesis; trans-cinnamate from L-phenylalanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the PAL/histidase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.24" evidence="6 13"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB71"/>
    <dbReference type="STRING" id="29730.A0A0D2UB71"/>
    <dbReference type="Gramene" id="KJB65241">
        <property type="protein sequence ID" value="KJB65241"/>
        <property type="gene ID" value="B456_010G086000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773643"/>
    <dbReference type="eggNOG" id="KOG0222">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQEMINP"/>
    <dbReference type="OrthoDB" id="10051290at2759"/>
    <dbReference type="UniPathway" id="UPA00713">
        <property type="reaction ID" value="UER00725"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045548">
        <property type="term" value="F:phenylalanine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009800">
        <property type="term" value="P:cinnamic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00332">
        <property type="entry name" value="PAL-HAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000009">
        <property type="entry name" value="Phenylalanine ammonia-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.20">
        <property type="entry name" value="Phenylalanine ammonia-lyase 1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001106">
        <property type="entry name" value="Aromatic_Lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022313">
        <property type="entry name" value="Phe/His_NH3-lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005922">
        <property type="entry name" value="Phe_NH3-lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023144">
        <property type="entry name" value="Phe_NH3-lyase_shielding_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01226">
        <property type="entry name" value="phe_am_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10362">
        <property type="entry name" value="HISTIDINE AMMONIA-LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00221">
        <property type="entry name" value="Lyase_aromatic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00488">
        <property type="entry name" value="PAL_HISTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="8 13" id="KW-0587">Phenylpropanoid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0597623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="694" mass="76403" checksum="5AA1F3E46BA28963" modified="2015-04-29" version="1">MATAEFGLSENGCCVSSTHLYWKKAADALHCSHFNEVTQMVSQFAEANTVEIQGTTLTVAQVTAISRRNQVMVSLDESTARDRVANSANWVTNNISRGTDTYGVTTGFGATSHRRTTKTADLQAELIRFLNAGVIGKENLPTSYSKAAMLVRANTLMQGYSGIRWEILEAMAELMNQNLIPKLPLRGTITASGDLVPLSYIAGLLTGRHNSKVVTLEGEEIEGIEALKRAGIGSPFELQAKEGLALVNGTAVGSAVAATVCFDANLLALLSVILSALFCEVMHGKPEFTDPLTHELKHHPGQIESAAIMKFLLDGSDYMKEAKIRHEKDPLTKPKQDRYAIRTSPQWLGPQIEVIRHATHSIEREINSVNDNPLIDVDRDIALHGGNFQGTPIGVSMDNLRIAIAAIGKLMFAQFSELVCDYYNNGLPSNLSGGSHPSLDYGFKGAEIAMAAYCSELQYLANPVTTHVQSAEQHNQDVNSLGLISARKSAEAIEILKLMSSTFMVALCQAIDLRHLEENMREVVKQVLLQVVKKTLYIAEDGSLLESRFCEKGLLQVIEHQPVFSYLDDPMNPSYTLLPKLRQVLVERALKDCKGDENGFSIFRRIPVFIEELKARLEEELPKARTKFGNGEFGIANRIEKCRSYPIYGFVRTEIGTQLLIGEKRVSPGEDIEKVYEAINEGKLGAVLMRCLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UG27</accession>
    <name>A0A0D2UG27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase RsuA/RluA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G204900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UG27"/>
    <dbReference type="STRING" id="29730.A0A0D2UG27"/>
    <dbReference type="Gramene" id="KJB67704">
        <property type="protein sequence ID" value="KJB67704"/>
        <property type="gene ID" value="B456_010G204900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774239"/>
    <dbReference type="eggNOG" id="KOG1919">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIYREQV"/>
    <dbReference type="OrthoDB" id="428658at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF88">
        <property type="entry name" value="RNA PSEUDOURIDINE SYNTHASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="3">
        <location>
            <begin position="109"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB67704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="382" mass="41923" checksum="68DE701C5D041C35" modified="2015-04-29" version="1">MSNHSRTQSLVFGIPWPELNDGLFYSDVVPHSDSELTLIDFYSRKYKNSAPLQGWLQRIQNGQISVDGRVVKDPNTILSGDSVLVYHRLPWKEPDVPHLLEVLYEDDDMVALNKPSGLQVLPGGLFQQRTVLTQLCWSVKKQNSTLNSQETHPVPVHRLGRGTSGILLCAKTKVAKTRLAAYFADGTSLVGATSNRKAARSGTRKISKIYRALVTGILVDDKVIIDQPIGIVRYPGVAKGLYVASPSGKPALSKVEVLERDEKQNCTLVQVEIESGRPHQIRIHLSFIGHPLLGDPLYIAGGEPRCFDPELVDESFAQDGGYQRPTNPVPGDCGYYLHAHRLVLSHPTTNEMIYITAPLSTILQTSDEANGSPGSVSINSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UGF8</accession>
    <name>A0A0D2UGF8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G175100</name>
        <name evidence="3" type="ORF">Gorai_008019</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UGF8"/>
    <dbReference type="Gramene" id="KJB67106">
        <property type="protein sequence ID" value="KJB67106"/>
        <property type="gene ID" value="B456_010G175100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4WI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLSWQES"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35758:SF1">
        <property type="entry name" value="SERINE RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35758">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB67106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0598247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="118" mass="12889" checksum="BE42994AAD08884B" modified="2015-04-29" version="1">MAMPTYASPRGVAMVLALIAAVVLSPLYVRRKHEMGYYDLKLSSGFVLPMVLAALLIAIRTTSSSSSMPSGGKAWLIPSPDPTWVSRIGGSSWGLAAILVMLTLELSWQESVKEFFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQT4</accession>
    <name>A0A0D2UQT4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G080300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
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                <person name="Grupp K."/>
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                <person name="Lin L."/>
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                <person name="Wang Z."/>
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                <person name="Walford S.A."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="4">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="3">
        <location>
            <begin position="101"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB61030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26689" checksum="01A5EDA32586311E" modified="2015-04-29" version="1">MVILVCRMSSITSDGQNKYCKKTGKGKRPGKGGNRFWKSIGLGFKTPREAIEGTYIDKKSPFTGTVSIRGRILTGTYHSAKMVRTIIVRRNYLHCIKKYQRQKWNIQFFGLDSQQKVTSSYVVVIGLGGVGSHAASMLLRSGVGKLLLVGFDQVAEKTAFLRPIELKLVPVPWKTFSSMIPKWLRKTKIVKQISQMLVNHLGLNLTKDDLQNVVDLMEPYGQISNGIEYLNPPLDVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYW2</accession>
    <name>A0A0D2UYW2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G283300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MIP/aquaporin (TC 1.A.8) family. PIP (TC 1.A.8.11) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYW2"/>
    <dbReference type="STRING" id="29730.A0A0D2UYW2"/>
    <dbReference type="Gramene" id="KJB74256">
        <property type="protein sequence ID" value="KJB74256"/>
        <property type="gene ID" value="B456_011G283300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777110"/>
    <dbReference type="eggNOG" id="KOG0223">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THESMTI"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000001">
        <property type="entry name" value="Probable aquaporin PIP1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00861">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45687">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB74256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="288" mass="30767" checksum="AE2F382AFA5A65DC" modified="2015-04-29" version="1">MEGKEEDVRLGANKFSERQPIGTAAQSQDDKDYTEPPPAPLFEPSELTSWSFYRAGIAEFVATFLFLYISVLTVMGVVKDKTKCTTVGIQGIAWAFGGMIFALVYCTAGISGGHINPAVTFGLFLGRKLSLTRAIYYMVMQCLGAICGAGVVKGFMGKTRYGALGGGANSVNHGYTKGDGLGAEIVGTFVLVYTVFSATDAKRSARDSHVPILAPLPIGFAVFLVHLATIPITGTGINPARSLGAAIIFNKDKGWDDHWIFWVGPFIGAALAALYHVVVIRAIPFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2W9</accession>
    <name>A0A0D2V2W9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 724B1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">(22S)-22-hydroxycampesterol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_012G065900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>campesterol + reduced [NADPH--hemoprotein reductase] + O2 = (22S)-22-hydroxycampesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69835"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:28623"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:72331"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:69836"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Plant hormone biosynthesis; brassinosteroid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Steroid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V2W9"/>
    <dbReference type="STRING" id="29730.A0A0D2V2W9"/>
    <dbReference type="Gramene" id="KJB75969">
        <property type="protein sequence ID" value="KJB75969"/>
        <property type="gene ID" value="B456_012G065900"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:brassinosteroid biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 724B1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF159">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 724, SUBFAMILY A, POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0349">Heme</keyword>
    <keyword evidence="7 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00052777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00060577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB75969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="475" mass="54066" checksum="4B42155A64B70207" modified="2015-04-29" version="1">MFGFFPLILSAFLLGLGFYLLLQVLARKKPANLPRGSMGWPLFGETLGFLKPHSSNSMGSFLQEHCSRYGRVFKSHLFGSPTIVSCDHELNMVVLQNEEKLFKVSYPRAMHGILGKFSLLIVSGDVHKKLRNIGVSFITSSKSNPEFLDCVEKMTISMMNSWKNCKEIGFYKEVKKFTLNLMVKHLLSIEPEEPLAFKILEDFLTYMKGFVSLPVYLPGTPYASAVKARARLSATVREIIKERRKEQLGLVKGDFLDAILSKENLSDEKTVSIVLDMLLAGYETTATLMALIVYFLSLYPNVLAHLKQEHNAIRKNKENGESLNWEDYQKMEFTCNVIYESLRCGNVVKFVHRVALQDVKFKGYFIPSGWKILPVLTAVHFDPSLHENPMEFNPWRWTDKATSKKVMPFGGGPRLCPGADLAKVEIAFFLHHLVLNYRWKTMADDSPLAYPYVEFRRGLLLEIEPIQAKAGKIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4K9</accession>
    <name>A0A0D2V4K9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G101200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB76694">
        <property type="protein sequence ID" value="KJB76694"/>
        <property type="gene ID" value="B456_012G101200"/>
    </dbReference>
    <dbReference type="OMA" id="TRNINGW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB76694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="125" mass="14265" checksum="9DB8E33E98A2784E" modified="2015-04-29" version="1">MFFFYYHRFCLSFYLHSHNSQIHSQLESLNTGKSLRCKTEGTLSLRTVLATKTITFESLTISPEQDLLSFLLYAISKLILANGLFGGFQLSFPSRLADLTLTSIIVFEKPGLHSYCAFWTNNHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V556</accession>
    <name>A0A0D2V556_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G138000</name>
        <name evidence="10" type="ORF">Gorai_004770</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V556"/>
    <dbReference type="Gramene" id="KJB77450">
        <property type="protein sequence ID" value="KJB77450"/>
        <property type="gene ID" value="B456_012G138000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77451">
        <property type="protein sequence ID" value="KJB77451"/>
        <property type="gene ID" value="B456_012G138000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77452">
        <property type="protein sequence ID" value="KJB77452"/>
        <property type="gene ID" value="B456_012G138000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781024"/>
    <dbReference type="eggNOG" id="ENOG502QV94">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SGAQACE"/>
    <dbReference type="OrthoDB" id="2156856at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.80:FF:000002">
        <property type="entry name" value="AT-hook motif nuclear-localized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014476">
        <property type="entry name" value="AHL15-29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100:SF16">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016021">
        <property type="entry name" value="ESCAROLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="8">
        <location>
            <begin position="80"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB77451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0601597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="281" mass="28419" checksum="7361F11D08494080" modified="2015-04-29" version="1">MESGAGSRYVHHLLGPELQLQRSSEPQFNSPEKQGTTDHPSAATTSSGGGSTTPGRRPRGRPAGSKNKPKPPIIVARDSPNSLRSHVLEISSGSDIVDSVSDYARRRGRGVCVLSGTGAVTNVTLRQPAAPPGSVVTLHGRFEILSLTGTSLPPPAPPGAGGLTVYLAGVQGQVVGGSVVGPLMASGPVVLMAASFANAVYDRLPLEEEDPPPVHEQQPAASQSSGLTGSGGGNNNNSGTTGTGVGGGGGVPFYNLGPNMGTYPFPGDVYGWSGSATRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V7J8</accession>
    <name>A0A0D2V7J8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G004500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V7J8"/>
    <dbReference type="STRING" id="29730.A0A0D2V7J8"/>
    <dbReference type="Gramene" id="KJB78541">
        <property type="protein sequence ID" value="KJB78541"/>
        <property type="gene ID" value="B456_013G004500"/>
    </dbReference>
    <dbReference type="OMA" id="WLAFPPC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38928">
        <property type="entry name" value="ARGOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38928:SF9">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="70" mass="7305" checksum="A32B08B67AB60C76" modified="2015-04-29" version="1">MSGCFRPFGFGGLLLLAALTASMLVLPLVLPPLPPPPLMLLFFPVGLMAALVFLAFSPAETVGNVVVHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGW3</accession>
    <name>A0A0D2VGW3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AT hook motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G015100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGW3"/>
    <dbReference type="STRING" id="29730.A0A0D2VGW3"/>
    <dbReference type="Gramene" id="KJB69300">
        <property type="protein sequence ID" value="KJB69300"/>
        <property type="gene ID" value="B456_011G015100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045881">
        <property type="entry name" value="MNM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34682">
        <property type="entry name" value="AT HOOK MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34682:SF3">
        <property type="entry name" value="AT HOOK MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB69300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43348" checksum="DB3AE715E8C7B757" modified="2015-04-29" version="1" fragment="single">MSSQNQGVSLSSPADPPMRRKRGRPRKDETVQGDNSPVTPVCDNLNKNKQSVDMSDPASEDMVGQMVSGVIEGSFDAGYLLNVKVGDTNTHLRGVVFLPGRFTPITAANDVAPNAKMYKRKEIPFPFVSPQGHLDATSPSGKSEKPIEHKNDTPKVLDQGLHIGIQSGATPVSESQSASILIPPASNLPMNDTGLPLGQKVLQDLIADIGLQNNKAVGVGQDQSLQGFEAFKLMKGPNINAEAPKASAPMSATFTGTLPVSETVNLKPQVEHQAVSFDLKPQELFGDGKSLDLVNNQTPKFPEPEPRAISCEPTAIDVFGKQASKFPEPEPQVMPCEPGGINMFGKRPSKFPEPETQPMTCEPTGINMFGKQASKFAEPEPQGMPCEPAEIHMFGKQASKFAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VHN4</accession>
    <name>A0A0D2VHN4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G234400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>Malvales</taxon>
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    </organism>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="6">
        <location>
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            <begin position="25"/>
            <end position="541"/>
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        </location>
    </feature>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VM04</accession>
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    <organism evidence="2 3">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB84439"/>
        <property type="gene ID" value="B456_N025600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253701" evidence="1">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB84439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="67" mass="7411" checksum="ADC4B683455FC999" modified="2015-04-29" version="1">MISQILSISLLQHALACHSKGCWTNKLYLMPASSFGSSIFVVSPYNTKNSFVQNFQRGILMSLSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VS31</accession>
    <name>A0A0D2VS31_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G264700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VS31"/>
    <dbReference type="Gramene" id="KJB73970">
        <property type="protein sequence ID" value="KJB73970"/>
        <property type="gene ID" value="B456_011G264700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73971">
        <property type="protein sequence ID" value="KJB73971"/>
        <property type="gene ID" value="B456_011G264700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="77" mass="9000" checksum="AC79689E17E6E727" modified="2015-04-29" version="1">MTRTNREMALKSSNEMENKELKNDRKLDCSLIYEINCRKEQLSQMEREYNEMTATLGGLINGLIAKINSKDSNLWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSA6</accession>
    <name>A0A0D2VSA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G268500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSA6"/>
    <dbReference type="STRING" id="29730.A0A0D2VSA6"/>
    <dbReference type="Gramene" id="KJB74035">
        <property type="protein sequence ID" value="KJB74035"/>
        <property type="gene ID" value="B456_011G268500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB74040">
        <property type="protein sequence ID" value="KJB74040"/>
        <property type="gene ID" value="B456_011G268500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776254"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071472">
        <property type="term" value="P:cellular response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd14736">
        <property type="entry name" value="BACK_AtBPM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18280">
        <property type="entry name" value="BTB_POZ_BPM_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000136">
        <property type="entry name" value="BTB-POZ and math domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045005">
        <property type="entry name" value="BPM1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034090">
        <property type="entry name" value="BPM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379">
        <property type="entry name" value="BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379:SF293">
        <property type="entry name" value="BTB_POZ AND MATH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="6">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="195"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45193" checksum="C04ED68EF69146CA" modified="2015-04-29" version="1">MRKRKKSTMDDSKDSASKSVSETVNGSHQFTIKGYSLAKGMGPGKCIASDIFTVGGYDWAVYFYPDGKNPEDTAMYVSVFIALASEGTDVRALFELTLVDQSGKGKHKVHSHFDRALESGPYTLKYRGSMWGYKRFYRRTTLESSDYIKDDCLIMNCTVGVVRTRLEGPKQCSIHVLPSDMGQNLKALLESEVGCDITFQVGDEAFKAHKLILAARSPVFRAQFFGLVGDPNIDKVVVKDVEPSVFKAMLLFIYSDKFPDIQEITGSGSTCMSTNMVQHLLAAADLYNLDRLKVLCEAKLCEKLNADTVATTLALAEQHHCSQLKAVCLKFAATPANLGAVMQSEGFRHLEESCPSLLSELLKAFASVEECASMLSSKKRSGSSVYGIDLAAEVHVAEPVNPNDRRVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXJ9</accession>
    <name>A0A0D2VXJ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_012G096600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Marler B.S."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
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                <person name="Grimwood J."/>
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                <person name="Walford S.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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                <person name="Frelichowski J.E."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <dbReference type="KEGG" id="gra:105783054"/>
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        <property type="component" value="Chromosome 13"/>
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    <dbReference type="InterPro" id="IPR022051">
        <property type="entry name" value="DUF3611"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34548">
        <property type="entry name" value="PROTEIN TIC 21, CHLOROPLASTIC"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR34548:SF2">
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    </dbReference>
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    </dbReference>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB79390.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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            <taxon>Tracheophyta</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Functional analysis and molecular cloning of Gossypium raimondii KCS genes.</title>
            <authorList>
                <person name="Xiao G.-H."/>
                <person name="Li Q."/>
                <person name="Zhu Y.-X."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ELO family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.199" evidence="3"/>
    <dbReference type="EMBL" id="KC160475">
        <property type="protein sequence ID" value="AGK30009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M9Z3A3"/>
    <dbReference type="STRING" id="29730.M9Z3A3"/>
    <dbReference type="Gramene" id="KJB16038">
        <property type="protein sequence ID" value="KJB16038"/>
        <property type="gene ID" value="B456_002G209600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TGQVAMF"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ELO_CS"/>
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    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
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        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
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        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012307"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AGK30009.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB16038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0581168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="274" mass="31106" checksum="70C9509F52267C14" modified="2013-06-26" version="1">MDRIYSSLQYWLVNHPKILHFQWTEGQTLGSTPLFLALTVLSYLTLTLLLSRSTLPSLGPNILKPITALHSLNLFLISLIMAVGCTLSIISLPSPLPHIICFPPNTPPTGPLFFWANIFYLSKLLEFIDTLLIILSNSKQRLTFLHVYHHGTVVVMCYLWLRTSQTLFPVALVTNATVHVIMYFYYLLSAMGIRPKWKRLVTNCQIVQFMFSFMVSVLMLYYHFSGLGCSGMLGWCFNAVFNASLLALFLDFHGKSYAAKQKKVAVVVDKDKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LRD9</accession>
    <name>A0A0D2LRD9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Ribulose-phosphate 3-epimerase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_001G269600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="12">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LRD9"/>
    <dbReference type="STRING" id="29730.A0A0D2LRD9"/>
    <dbReference type="Gramene" id="KJB06537">
        <property type="protein sequence ID" value="KJB06537"/>
        <property type="gene ID" value="B456_001G269600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769478"/>
    <dbReference type="eggNOG" id="KOG3111">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHLMIED"/>
    <dbReference type="OrthoDB" id="1927044at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000181">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB06537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="226" mass="24531" checksum="0EE939C238E80AFD" modified="2015-04-29" version="1">MGVTPKIAPSMLSSDFANLASEAKRMLDFGADWLHMDIMDGHFVPNLTIGAPVIESLRKHTKAYLDCHLMVTNPIDYVEPLGKAGASGFTFHVEVSKENWQELIQKIKLKGMRPGVALKPGTPIEEVYPLINSENPVEMVLVMTVEPGFGGQKFMPEMMEKVRMLRNKYPSLDIEVDGGLGPSTIDVAASAGANCIVAGSSVFGAPEPAAVISLMRKSVLENQEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MBV3</accession>
    <name>A0A0D2MBV3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G163100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MBV3"/>
    <dbReference type="STRING" id="29730.A0A0D2MBV3"/>
    <dbReference type="Gramene" id="KJB15167">
        <property type="protein sequence ID" value="KJB15167"/>
        <property type="gene ID" value="B456_002G163100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785528"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWPEERF"/>
    <dbReference type="OrthoDB" id="779276at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF397">
        <property type="entry name" value="OS11G0242500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="156"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="621"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="697"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="739" mass="82618" checksum="AF726D5DC6AAF09C" modified="2015-04-29" version="1">MGCICSKGSRANEYVENNHGKRDKAHKNSRKTAKKLSVSFKRDNVVVEADATARLISNQQPNHGAVSGPSSSSDDEEKKAALAVFERSKGTPSELQRRPTTEADGRGGQGRQRMSRIINATGGERGAQVVAGWPSWLAAVAGEAINGWIPRKAESFEKLEKIGQGTYSSVYKARDLESNKIVALKKVRFVNMDPESVCFMAREIIILRRLDHPNVMKLEGLITSRASGSLYLIFEYMEHDLAGLLATPEVKFTEAQIKCYMQQLLRGLDHCHSRGVLHRDIKGSNLLIDCNGNLKIGDFGLATFFHPNQKQPLTSRVVTLWYRPPELLLGSTNYGVAVDLWSSGCILAELFAGKPIMPGRTEVEQLHKIFKLCGSPSEDYWKRSKLPHATIFKPQHPYKSCVLETFKDFPTSALVLLEVLLAIEPECRGTASSALQSEFFTTLPLPCNPSSLPKYPPSKEFDAKLREEESRRQRAGGKVHAVDPVRKFSRESIAIPAPDFNAELQASIQKWRGQFDAKSISEVWYPEEDRGAGFPIEPSKGTERVVYNSHSGQLMHPGKFESSRNKKTTEIESMKASARAFGFPRKPEELKTQTCVHRGAVELSRFSNSIAVRGSSRFDMTKENNINPHWPEERFNSGYNHLDNAESSEKHDLSHGLLDRPKASNVKDEQPSSKESAVGYVSMNNRVHYSGPLMPRGGNLEEMLKEHERRIQNAVRRARSNKTKAKINFDDNGQTESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MMQ1</accession>
    <name>A0A0D2MMQ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G118500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of SAE1A or SAE1B and SAE2. The complex binds SUMO proteins via SAE2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MMQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2MMQ1"/>
    <dbReference type="Gramene" id="KJB19777">
        <property type="protein sequence ID" value="KJB19777"/>
        <property type="gene ID" value="B456_003G118500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788661"/>
    <dbReference type="eggNOG" id="KOG2014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SENIKCH"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01492">
        <property type="entry name" value="Aos1_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000404">
        <property type="entry name" value="SUMO-activating enzyme subunit 1B-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="10">
        <location>
            <begin position="14"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB19777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="323" mass="36163" checksum="5AC63148D790FF01" modified="2015-04-29" version="1">MDGEELTEQETALYDRQIRVWGADAQRRLSKSHILVCGLKGTVAEFCKNIVLAGVGSVTLVDDRVVTDESLPANFLILPHENHYNGKTLAEVCCDSLKEFNPMVDVAVETGDISTFGVEFFEKFDAVIISCCSLGKKKLINQKCRKLSKRVAFYTVECRGSCGEMFVDLQDYKYSKKKLEETIECQIEYPSFEEAISVPWRALPRRVSKLYFAMRVIEQFEDVEGRNPGETSIADRLGVLKLRKELCETNSLDESQIPDALLERLLTDTREFPPVCAIIGGILGQEVIKAISGKGDPLKNFFFFDAMDGKGLIEDISGPSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MPQ8</accession>
    <name>A0A0D2MPQ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G162800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MPQ8"/>
    <dbReference type="STRING" id="29730.A0A0D2MPQ8"/>
    <dbReference type="Gramene" id="KJB20752">
        <property type="protein sequence ID" value="KJB20752"/>
        <property type="gene ID" value="B456_003G162800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB20753">
        <property type="protein sequence ID" value="KJB20753"/>
        <property type="gene ID" value="B456_003G162800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789159"/>
    <dbReference type="OMA" id="QKKTTPF"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13170">
        <property type="entry name" value="RanBD_NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF141">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="4" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="6">
        <location>
            <begin position="302"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="124"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB20752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="446" mass="47884" checksum="37BBC9A70B93BC1E" modified="2015-04-29" version="1">MNGTKRFALSSSAADANDSAFRNKRIMAGYPFDPQRAEPSQQQPNATPALDPQRAELSRRHVKALNIQFASWVQSQLKNHPDELWQDGVSDYLSHASHIMDKFSDVVNWLKANAANGDSLSAAESHKNESKNVPETKNTENKFFQGKIGFTPTSTTTSLIPGSTTLSFSPGTTTMSFSPGTTAGMFSLNTTTTRSTPADMTKKFPPLGTTTSFTSASSTTSFTPVGLTTSSMAAGSNSSFSFGLSTANFTSSSTTNSFTSSNMTSGFASPWSTGAFSNSQSPFLFGTQSSVSVDNNAADDADDENELPRPSSPSVKKSEEKGIVVVHEVKCKLYVKSTDPEDKDSWKDKGTGQLSIKCKEGISKGSKDSKPTIVVRNEVGKLLLNALLYPGIKTSAQKNSLVAIFHTSDEGGDNQEVVARTFLIRTKTEDDRNKLVTAIQEYAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MWJ8</accession>
    <name>A0A0D2MWJ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G109800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MWJ8"/>
    <dbReference type="STRING" id="29730.A0A0D2MWJ8"/>
    <dbReference type="Gramene" id="KJB23612">
        <property type="protein sequence ID" value="KJB23612"/>
        <property type="gene ID" value="B456_004G109800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0R1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLDCRVQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd09487">
        <property type="entry name" value="SAM_superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33915">
        <property type="entry name" value="OSJNBA0033G05.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33915:SF3">
        <property type="entry name" value="STERILE ALPHA MOTIF (SAM) DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB23612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="326" mass="37310" checksum="D06F29AD1CFD1076" modified="2015-04-29" version="1">MSLYNAFGSSNSTRLDHPRETITTPQTSNLFSVLWHKPSSIAMDWYSWLSKTALEPSLIYDYGLAFSRNELQKEDLAYFNHEFLQSMGISVAKHRLEILKLARKEVGETPNSLSKLILAINKTRKSFNKYVNKLVHHENNSIKRLPEPGRYRDQWRGGLTRKCNSEKEVNIEQPVRRTRKIAKSGPLDCRVQEKLLAPPRSLKLSGPLDRKMQENLVFNYKSPVTSGPIDIAIAQERLILTTNRSPKLSAPLTYVRPPSPKIHVFSGKVRYMSFRCFLPLRGASLYAFASEPDSDIRLGCPKISILKSCWTVLFIINTHLIVLYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MYR9</accession>
    <name>A0A0D2MYR9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
            <ecNumber evidence="2">2.4.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G154200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyltransferase 77 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.-" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MYR9"/>
    <dbReference type="STRING" id="29730.A0A0D2MYR9"/>
    <dbReference type="Gramene" id="KJB24627">
        <property type="protein sequence ID" value="KJB24627"/>
        <property type="gene ID" value="B456_004G154200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QT5X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035252">
        <property type="term" value="F:UDP-xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010306">
        <property type="term" value="P:rhamnogalacturonan II biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005069">
        <property type="entry name" value="Nucl-diP-sugar_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052636">
        <property type="entry name" value="UDP-D-xylose:L-fucose_XylT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47032:SF1">
        <property type="entry name" value="UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03407">
        <property type="entry name" value="Nucleotid_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="120"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleotide-diphospho-sugar transferase" evidence="3">
        <location>
            <begin position="269"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB24627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="415" mass="47261" checksum="017EA45A13689E11" modified="2015-04-29" version="1">MSSFLHQRPIQNPFSNAYPVSPRSSSTSQRPISIFSPTGLIILLSLMVILGVFVPWSGMPVATFSNSKKASSSLSKWRDYTLAEAASFVAKNGTLIVCAVSQPYLPFLNNWLISITRQKHQEKVLVIAEDYATLYKVNEKWPGHAVLVPPAIDSQTAHKFGSQGFFNFTSRRPQHLLKILELGYNVMYNDVDMVWLRDPFPYLEGNHDVYFTDDMAAWIVVVKRMERMERRLNLVLNLIVAPLPQTLGCYILEILLPLLLYRKVASCYFSLVDQVKALNHSHDLPPPGKKGRTYICSCMIFLRPKDGAKLVMKKWIEELQAQPWSKAKKANDQPAFNWALNKTAGLVDLYLLPQAAFPTGGLYFKNQTWVQQTKGMHVIIHNNYIIGFEKKIKRFQDYGLWLVDDHALDSPLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N214</accession>
    <name>A0A0D2N214_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ycf1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G219800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N214"/>
    <dbReference type="STRING" id="29730.A0A0D2N214"/>
    <dbReference type="Gramene" id="KJB25982">
        <property type="protein sequence ID" value="KJB25982"/>
        <property type="gene ID" value="B456_004G219800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB25982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="21849" checksum="FF65346D777783A7" modified="2015-04-29" version="1" fragment="single">KKKVPNEKQIIGLENRNQEEKEPIGEGGLVSDAQKQGNFKSVLSNQEKDVEENQTKKNVERKIYCLLHRLINPNEIVISSIQRGEMNLDILMIQKDLTLRELMKKGILIIDPVRLLVKNDGQFILYQTIILTKNKYLDSDKLMFFLWPNYRLEDLACMNRYWFNTNNGSRFSMIRIRMYPSLKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N542</accession>
    <name>A0A0D2N542_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G287900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N542"/>
    <dbReference type="STRING" id="29730.A0A0D2N542"/>
    <dbReference type="Gramene" id="KJB27267">
        <property type="protein sequence ID" value="KJB27267"/>
        <property type="gene ID" value="B456_004G287900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRGN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLTCGGN"/>
    <dbReference type="OrthoDB" id="1858978at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1320.10">
        <property type="entry name" value="Outer-capsid protein sigma 3, large lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053168">
        <property type="entry name" value="Glutamic_endopeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004314">
        <property type="entry name" value="Neprosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025521">
        <property type="entry name" value="Neprosin_propep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589:SF2">
        <property type="entry name" value="ASLB (DUF239)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
        <property type="entry name" value="PROTEIN, PUTATIVE (DUF239)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03080">
        <property type="entry name" value="Neprosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14365">
        <property type="entry name" value="Neprosin_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
        <property type="entry name" value="NEPROSIN_PEP_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247483" description="Neprosin PEP catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="2">
        <location>
            <begin position="156"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB27267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="418" mass="46287" checksum="F10F783DD8A2EE53" modified="2015-04-29" version="1">MANFIFGVFLILVLSYLSNRVTGKAPVKEIHADVDGKLKQLNKPAVKTIQSDDGDIIDCVDIYRQPAFDHPALRNHVIQMKPNFNFKEMEFNSKNGSSKLTVFQTWQKSGSCPKGTVPIRRIRREDLLRAQSVQQFGRKPQEVVLKSNTTIGRFPSINSNALALPAIVNRSAAILATVGANYTGAKADINVWNPNVESEDFTTAQVWLKAGPNDNFESIESGWTVNPQLYGDKKTRLFAHWTKDSYKTTGCFDLQCSGFIQTSSKIALGAAISPISMELGQQYYITIGIYMDENTNNWWLIFGNGITIGYWPASTLNVLKNSATMVEWGGQVYSPNVRKSPHTKTAMGSGKFASSLKGNACYMENIGIVDFSTQLQYPPAVTTLAEENYCYTALNHQDGSESSPTFYFGGPGQNYNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N553</accession>
    <name>A0A0D2N553_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MHD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G288600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N553"/>
    <dbReference type="STRING" id="29730.A0A0D2N553"/>
    <dbReference type="Gramene" id="KJB27280">
        <property type="protein sequence ID" value="KJB27280"/>
        <property type="gene ID" value="B456_004G288600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27282">
        <property type="protein sequence ID" value="KJB27282"/>
        <property type="gene ID" value="B456_004G288600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27283">
        <property type="protein sequence ID" value="KJB27283"/>
        <property type="gene ID" value="B456_004G288600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792979"/>
    <dbReference type="OMA" id="SKREMAP"/>
    <dbReference type="OrthoDB" id="2015333at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014770">
        <property type="entry name" value="Munc13_1"/>
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    <dbReference type="InterPro" id="IPR014772">
        <property type="entry name" value="Munc13_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057984">
        <property type="entry name" value="PATROL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008528">
        <property type="entry name" value="unc-13_homologue"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31280:SF4">
        <property type="entry name" value="ELONGATION FACTOR TS (DUF810)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31280">
        <property type="entry name" value="PROTEIN UNC-13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25761">
        <property type="entry name" value="TPR_PATROL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51258">
        <property type="entry name" value="MHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51259">
        <property type="entry name" value="MHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="549"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="MHD2" evidence="3">
        <location>
            <begin position="824"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB27282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="994" mass="110660" checksum="47C8F663DD558C66" modified="2015-04-29" version="1">MAHLFRDLSLGHSKRESTPPPPPLQTKPPPMPTNKLTSPDLQSPLGQLASQLTDSDLRLTAYDVFLAVCRTSASKPLSTSASSISDSSSQNSPGQNHNHSPSSPALQRSLTSAAASKMKKALGLKSPGSKKSPGSAPSSGQGKSKRPTTVGELMRIQMRVPESVDARVRRALLRIGGGLVGRRIESVVLPLELLQQLKQSDFSDQQEYDAWQKRNLRVLEAGLLLHPRVPLDKSNNASQRLRQIIHAALDRPIETGKNNESMQVLRSAVMSLASRSDGSLSDSCHWADGIPLNLRLYEMLLEMCFDINDETSIVEEVDELMEQIKKTWVILGINQMLHNLCFAWVLFHHFVSTGQVEMDLLYAADGQLAEVAKDAKTTRDPEYSKILSSTLSSILGWAEKRLLAYHDTFDSGNVYTMQGIVSLGVSAAKILVEDVSTEYRRKRKEVDVARNRIDTYIRSSLRTAFAQRMEKADSSRRASKNQPNPLPVLAILAKDVGELAVHEKQVFSPILKGWHPLAAGVAVATLHSCYANEIKQFISGITELTPDAVQVLRAADKLEKDLVQIAVEDAVDSDDGGKAIIREMPPYEAETAIANLVKGWIKTRLDRLKEWVDRNLQQEVWNPQANQEGFALSAVETLRIIDETLDAFFQLPIPAHPALLPDVIVGLDKCLQYYVIKAKSGCASRNTYIPTMPALTRCEIGSKFQGVWKKKEKSQNTQKRNSQVATMNGDKSFGIPQLCVRINTLHHIRSEMDVLEKRIVTHLRNCESAHLEDFSNGLSKRFELTPAACVEGVQQLSEAVAYKIVFHDLSHVLWDGLYVGEPSSSRIDPLLQELEQNLLVISETVHDRVRTRIITDIMKASCDGFLLVLLAGGPSRAFSRQDSQIIEDDFKALKDLFWANGDGLPADLIDKFSATVRDFLPLFRTDTESLIERFKRMTLEAYGSSARSRLPLPPTSGQWNPTEPNTLLRVLCYRNDEAASRFLKKTYNLPKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9S9</accession>
    <name>A0A0D2N9S9_GOSRA</name>
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        <recommendedName>
            <fullName evidence="11">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G091200</name>
        <name evidence="8" type="ORF">Gorai_016348</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9S9"/>
    <dbReference type="STRING" id="29730.A0A0D2N9S9"/>
    <dbReference type="Gramene" id="KJB29252">
        <property type="protein sequence ID" value="KJB29252"/>
        <property type="gene ID" value="B456_005G091200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LHMKLGK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="11"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB29252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0585578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56379" checksum="E52792A5D15B0EAB" modified="2015-04-29" version="1">MEELQASLQPRGLTLSTFPDKGRSLLAARDFYPGEVIISQDPYVCVPNNSLTESRCDGCFSKSNLKKCSACHVVWYCGSSCQKLEWKLHRFECQLLAKLDKERRKSVTPTIRMIVKLYLRRKLQNENVIPVTAMDNYNLVEALVSPILFSLKLEKDMSDIDEKQLLLYAQMANLVNLILQLPNIDIKEIAENFSKFACNAHTICDSELRSLGTGLYPVISIINHSCLPNAVLVFEGRLAVVRAVQHIPKDSEVSISYVETAASTITRQKTLKEQYLFTCTCVRCNKLGQYDDIQESAILEGYRCRDNGCSGFLLRESDEKGFVCQQCGLIRNKEEIRKIASDIKALSDKALKCSSSGNLQEAIVLYKNIEKLQKEVCHPFSIILMRTREKLLEILMQLEEWKEALAICRLTIPVYERVYPGFHPLLGLQYYSCGKLEWLLGETDDAIKSFTKAVDILRITHGTSTPFMKELLMKLEEARAEASFKLSSREDSYITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NDP7</accession>
    <name>A0A0D2NDP7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH:quinone oxidoreductase/Mrp antiporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G160600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NDP7"/>
    <dbReference type="STRING" id="29730.A0A0D2NDP7"/>
    <dbReference type="Gramene" id="KJB30797">
        <property type="protein sequence ID" value="KJB30797"/>
        <property type="gene ID" value="B456_005G160600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHIRNYR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22773">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="104" mass="11813" checksum="593A11F0518E94A8" modified="2015-04-29" version="1" fragment="single">GLPPLAGFFGKLHLFWCGWQAVLYFLVSIGLLTSLFSIYYYLKIIKLLMTGRNQEITPHIRNYRKSPLRSINSIELSMIIYVIASTILGISMNSIIAIAQDTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQB5</accession>
    <name>A0A0D2NQB5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_002G196200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the amino acid/polyamine transporter 2 family. Amino acid/auxin permease (AAAP) (TC 2.A.18.2) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQB5"/>
    <dbReference type="STRING" id="29730.A0A0D2NQB5"/>
    <dbReference type="Gramene" id="KJB15783">
        <property type="protein sequence ID" value="KJB15783"/>
        <property type="gene ID" value="B456_002G196200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785901"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMPSRIH"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000055">
        <property type="entry name" value="Amino acid permease 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0769">Symport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="60"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="512" mass="56533" checksum="FE4F09682C767A2A" modified="2015-04-29" version="1">MLPRSRTMPSRIHHGVVEERHDIKHYLQVEVQPKAQNESNATNSLPDYSKCFDDDGRLKRTGTFWTATSHIITAVIGSGVLSLAWAIAQLGWVAGPTVLVLFAFVNLYTSNLLAECYRSGDLVTGQRNYTYMEAVKAHLGGWKVKLCGWIQYLNLFGVAIGYTIAASVSMMAIKRSNCFHKSGGKDPCHMSSNGYMISFGIAEVIFSQIPNFSHIGWLSIVAAIMSFTYSSVGLGLGIGKVAEHERFDGSLLGISIGTVTHAGTVTGMQKIWRTLQALGAIAFAYSYSVILIEIQDTVKSPPAEYTTMKKATLFSITVTTVFYLLCGCFGYAAFGDLSPGNLLTGFGFYNPYWLLDIANLAIVIHLVGAYQVFCQPLFAFVEKWCAQKWPNCNFVTAEYEIPTPFGGVYELNLFRLVWRTIFVAITTIIAMLMPFFNDVVGFLGAMGFWPLTVYFPIEMYISHKKVGRGTSRWLALQIISVACFFVTVAAAVGSIAGVVLDLKTYKPFKTSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NTA8</accession>
    <name>A0A0D2NTA8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine-containing phosphotransfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G156600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a two-component phosphorelay mediators between cytokinin sensor histidine kinases and response regulators (B-type ARRs). Plays an important role in propagating cytokinin signal transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Histidine-containing phosphotransfer domain (HPt) contains an active histidine that mediates the phosphotransfer.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NTA8"/>
    <dbReference type="STRING" id="29730.A0A0D2NTA8"/>
    <dbReference type="Gramene" id="KJB36387">
        <property type="protein sequence ID" value="KJB36387"/>
        <property type="gene ID" value="B456_006G156600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799691"/>
    <dbReference type="eggNOG" id="KOG4747">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QACDANS"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000001">
        <property type="entry name" value="Histidine-containing phosphotransfer protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF64">
        <property type="entry name" value="HISTIDINE-CONTAINING PHOSPHOTRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HPt" evidence="8">
        <location>
            <begin position="38"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB36387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="148" mass="16873" checksum="94A1D7B5B772B623" modified="2015-04-29" version="1">MDLAALKTQLKNFVQSMFEEGVLDNQFSQIQALQDSTNPNFVEEVITLFCNDAERIVNEINRNLGYQNVDFSNLDSYVHQLKGSSSSIGANRLKLACANLRQASDERNKEGCLQALQLITCEYCLLRRKFQALLHLERSIVELETNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NYA0</accession>
    <name>A0A0D2NYA0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G083900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NYA0"/>
    <dbReference type="STRING" id="29730.A0A0D2NYA0"/>
    <dbReference type="Gramene" id="KJB19073">
        <property type="protein sequence ID" value="KJB19073"/>
        <property type="gene ID" value="B456_003G083900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQAVCQT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="63"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB19073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="497" mass="53996" checksum="50E5C953455BA2EF" modified="2015-04-29" version="1">MGNCFPSLFHARTRRPIQFSAAALVSGFPNLRLNETTGSGCILSPPLLKSFTYSELEQATMNFSSQNLIGEGGFGYVYMGFIDEQTLSAASPESGMAVAVKKLSPTGTQGHEQWLTELGNLGRLRHRNLVKLYGYCSQGEDRLLVYEYLSKGSLQDLLFKDCSPPLSWETRVGIAIDTARVLSFLHELGLILRDIKSANILLDSDFSAKLSDLGYAIEGPTGDQSYVLTRVFGTEGYTDPQYLATGMLNTKCDVYSFGVVLLELLSGRQAVCQTAAGIMEFLVDWAKPYLGDKRLLSRIMDTKLNGNYSKREAYGVAVIALQCVSEDKVRPSMAEVLSALRRLRLLSGSHASPSGVPSSSVGFKVDRPWLPLPPLDSVSSQRSISPLCSSDFSSPRHVPSSPSNGPRSSLSSQSDGPPFSLRELRRQLFSRQDRGSSGRTISPPLASTLSPSDLPLSFLGSPSNVSGLVSPSSDVPQVKSSKYNNKYPLKGALWNSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PCN5</accession>
    <name>A0A0D2PCN5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyl hydrolase family 13 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G204700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PCN5"/>
    <dbReference type="STRING" id="29730.A0A0D2PCN5"/>
    <dbReference type="Gramene" id="KJB43532">
        <property type="protein sequence ID" value="KJB43532"/>
        <property type="gene ID" value="B456_007G204700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005982">
        <property type="term" value="P:starch metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="8471" checksum="FFF563F002C3A603" modified="2015-04-29" version="1">MFDGTDAHYFRTGLRGHHSVWDSRLFNYGSWEVLRYLLSYARWWLEEYKFDGYRFDGVTSMMYKISLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PH35</accession>
    <name>A0A0D2PH35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E1 ubiquitin-activating enzyme</fullName>
            <ecNumber evidence="6">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_004G233800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="6"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PH35"/>
    <dbReference type="STRING" id="29730.A0A0D2PH35"/>
    <dbReference type="Gramene" id="KJB26263">
        <property type="protein sequence ID" value="KJB26263"/>
        <property type="gene ID" value="B456_004G233800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792437"/>
    <dbReference type="eggNOG" id="KOG2012">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000002">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018074">
        <property type="entry name" value="UBQ-activ_enz_E1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF215">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00536">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="15">
        <location>
            <begin position="996"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB26263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125372" checksum="59C1A0E2F16BEA2A" modified="2015-04-29" version="1">MCGMDDNMKLSTLAALTIVFLGFYGIFGSLMHYMLPRKRAGEGEVVEGESENDNNNINDVTVSPPTKKHRISTTAAADLTADNKSVTTGDNSSNYSNTCVIEPSVMAPRDANHNDIDEDLHSRQLAVYGRETMRRLFASNILISGMQGLGAEIAKNLILAGVKSVTLHDEGVVEMWDLSSSFVFSENDVGKNRALASLQKLQELNNAVVISTLTTTLTKQKLSDFQAVVFTDISLEKSLEYNDYCHNHQPPISFIKTEVRGLFGTVFCDFGPKFTVFDVDGEEPHTGIIASISNDNPALVSCVDDERLEFEDGDLVVFSEIQGMKELNDGKPRKIKSVRPYSFTLEEDTTNFGTYVKGGIVTQVKQPKVLNFKPLRAALKDPGDFLLSDFSKFDRPPLLHIAFQALNRFICEFGRFPVARSEEDAQKFISIAGNINECLGEGGVEDINPKLLTHFAFGARAVLNPMAAMFGGIVGQEVVKACSGKFHPLFQFFYFDSVESLPVEPLDPIDFKPLNSRYDAQISVFGSKLQKNLEDAKVFIVGSGALGCEFLKNVALMGVSCGSQGKLTITDDDVIEKSNLSRQFLFRDWNIGQAKSTVAASAAVSINPQLKIEALQNRVGPETECVFNDDFWENLTVVINALDNVNARLYVDQRCLYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPTEKQAPMCTVHSFPHNIDHCLTWARSEFEGLLEKTPAEVNAYLSNPSEYATAMRNAADAQAKDNLERILQCLEQEKCETFQDCVTWARLRFEDYFVNRVKQLTFTFPEDATTSTGAPFWSAPKRFPRPLQFSTTDPSHLQFIMAASILRAETFGIPVPDWVKNTKMLAKAVEKVIVPDFQPKEGVKIETDEKATSLSTGSVDDAAVINELLFKLERCRNNLPSGFRMKPIQFEKDDDTNYHMDLIAGLANMRARNYSIPEVDKLKAKFIAGRIIPAIATSTAMATGLVCLELYKVLDGAHKVEDYRNTFANLALPLFSMAEPVPPKVMKHRDMSWTVWDRWILSGNPTVRELIQWLKDKGLNAYSISYGSCLLFNNMFPRHKERLDKKVVDVAREIAKEDLPPYRSHLDVVVACEDDEDNDINIPQISVYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PH60</accession>
    <name>A0A0D2PH60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hexosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_004G235400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>myo-inositol + UDP-alpha-D-galactose = alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12464"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.123"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 8 family. Galactosyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PH60"/>
    <dbReference type="STRING" id="29730.A0A0D2PH60"/>
    <dbReference type="Gramene" id="KJB26288">
        <property type="protein sequence ID" value="KJB26288"/>
        <property type="gene ID" value="B456_004G235400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792455"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEATWAH"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047216">
        <property type="term" value="F:inositol 3-alpha-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000049">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB26288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="37793" checksum="520E95F2E78D95EE" modified="2015-04-29" version="1">MEGVATAKTVRPSSPKRAFVTFLAGNGDYVKGVVGLAKGLRKVKSKYPLVVAVLPDVPDDHKKILVDQGCIVKEIDPVYPPENQTQFAMAYYVINYSKLRIWEFVEFSKMIYLDGDIQVFDNIDHLFDMEDGYFYAVMDCFCEKTWSQTPQYKIGYCQQCPDKVQWPSRLGPKPPLYFNAGMFVYEPNLSVYGDLLTTLKVTPPTPFAEQDYLNMYFRDIYRPIPPIYNLVMAMLWRHPENIELEKVKVVHYCAAGSKPWRFTGKEDNMDRKDIKTLVTKWWDIYNDESLDYANAVGYGEAEDEQTGLEPFLAAMSDACVVQYINAPSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PM36</accession>
    <name>A0A0D2PM36_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G053000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PM36"/>
    <dbReference type="STRING" id="29730.A0A0D2PM36"/>
    <dbReference type="Gramene" id="KJB07924">
        <property type="protein sequence ID" value="KJB07924"/>
        <property type="gene ID" value="B456_001G053000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785588"/>
    <dbReference type="eggNOG" id="KOG1051">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMTEDTE"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF185">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="81"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="563"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB07924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="946" mass="103899" checksum="744BCC1DCA7F46DD" modified="2015-04-29" version="1">MDVLCSSSLAIHLHSRSIFPSSPPRFPFRFHRTFYYNNSIYSSSSSSCFGLSISRCNNFVHHVKHPHSFKRRKAIQISAVFERFTERAIKAVILSQREAKSLGKDMVFTQHLLLGLIGEDRDPNGFLGSGLKIENARDAVRSIWQSSNHGEDLGNKQQGSIVSSTDVPFSISTKRVFEAAVEYSRTMGYNFIAPEHIAIGLFTVDDGSASRVLKRLGANINHLAAEAVTRLQGELAKDGREPSLSSKKMSEKSSSGNAAVLRSPDKTKGKSALAQFCIDLTARASEGLIDPVIGRETEVQRIVQILCRRTKNNPILLGESGVGKTAIAEGLAISIAQAEIPAFLLNKKIMSLDIGLLMAGAKERGELEARVTALLSETKKSGNIILFIDEVHTLIGSGTVGRGNKGSGLDIANLLKPALGRGELQCIASTTIGEYRTQFEKDKALARRFQPVWINEPSQEDAVGILLGLREKYESHHHCRYTLEAINAAVYLSARYIPDRYLPDKAIDLIDEAGSRARIEAFRRKREQETDILSKAPNDYWEEIRTVQAMHEVVIASRLKNDAGASGVDDSSELLESESPLPSTSENDEPIMVGPEEIAAVASIWSGIPVQQLTADERMLLIGLDEMLKKRVIGQDEAVAAISRAVKRSRVGLKDLDRPIAAMIFCGPTGVGKTELTKALAACYFGSEDAMLRLDMSEYMERHTVSKLIGSPPGYVGYEEGGMLTEAIRRRPFMLLLLDEIEKAHPDIFNILLQLFEDGHLTDSQGRRVSFKNALVVMTSNVGSSAIAKGRRGSIGFLLENDESSSYAGMKALVMEELKAYFRPELLNRIDEVVVFRSLEKLQMLEIVNLMLQEVNARLVSLGIGLEVSESIKDLICQQGYDQTYGARPLRRAVTAIVEDPLSEALLAGNYSPGETAVIDLDALGNPIVTSRSDRNISLSDTASIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PNM2</accession>
    <name>A0A0D2PNM2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G043300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PNM2"/>
    <dbReference type="STRING" id="29730.A0A0D2PNM2"/>
    <dbReference type="Gramene" id="KJB47822">
        <property type="protein sequence ID" value="KJB47822"/>
        <property type="gene ID" value="B456_008G043300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763010"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000015">
        <property type="entry name" value="DUF21 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF59">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="8"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="210"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB47822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47464" checksum="A5D7ECA6E55BAFD3" modified="2015-04-29" version="1">MAVEYKCCGTDFFIHILVIVLLVVFAGLMSGLTLGLMSMSLVDLEVLAMSGTPNDRRHAAKILPVVRKQHLLLCTLLLCNAAAMEALPIFLDSLVTAWGAILISVTLILLFGEIIPQSVCSRYGLAIGARVAPFVQVLVWVCFPIAYPISKLLDLLLGHGHVALFRRAELKTLVNLHGNEAGKGGELTHNETTIIAGALELGAKTAKDAMTPISEAFAVDINAKLDRDLMNLVLEKGHSRVPVYYEQTTNIIGLILVNNLLTIHPEDEVPVKSVTIRRIPRVEEELPLYDILNEFQKGHSHMAVVVRQCNRTDESPSNRDGRPLQEVRVDMDADKHPKEKVLRRKRSLKWKSFPATGRSFKGGSRSKKWTKGTDSDILHLNDNPLPTLPEEAIGIITMQDVIEELLQVPLTLFNKFLISIFSTLDSYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSS0</accession>
    <name>A0A0D2PSS0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G077300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + H2O = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21209"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSS0"/>
    <dbReference type="STRING" id="29730.A0A0D2PSS0"/>
    <dbReference type="Gramene" id="KJB07019">
        <property type="protein sequence ID" value="KJB07019"/>
        <property type="gene ID" value="B456_001G077300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07020">
        <property type="protein sequence ID" value="KJB07020"/>
        <property type="gene ID" value="B456_001G077300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07021">
        <property type="protein sequence ID" value="KJB07021"/>
        <property type="gene ID" value="B456_001G077300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1615">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTWRNAD"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04309">
        <property type="entry name" value="HAD_PSP_eu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.210:FF:000003">
        <property type="entry name" value="Phosphoserine phosphatase SerB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000077">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000114">
        <property type="entry name" value="Phosphoserine phosphatase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.210">
        <property type="entry name" value="Phosphoserine phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB07021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="296" mass="32375" checksum="D385DF0A6079BDFA" modified="2015-04-29" version="1">MEGLVNSRIIPIRTSCRRHYSVFLPTFSLQLRNKNLNKGQVWMMRRPKSLDSVAASIQPLEASTTGNTDNRQPSKEVLELWRSADAVCFDVDSTVCVDEGIDELAEFCGAGKAVAEWTARAMGGSVPFEQALSARLSLFKPSLAQVQDFLDKRPPRISPGIEELVKKLMARNTDVYLISGGFRQMINPVASILGIPQENIFANQLLFGSSGEFLGFDANEPTSRSGGKATAVQQIRKVKGYKALVMIGDGATDLEARKPGGANLFICYAGVQHRESVAAKANWLVFSFTDLITALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PWB9</accession>
    <name>A0A0D2PWB9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G171300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PWB9"/>
    <dbReference type="Gramene" id="KJB50447">
        <property type="protein sequence ID" value="KJB50447"/>
        <property type="gene ID" value="B456_008G171300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R2DM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00261">
        <property type="entry name" value="AAI_SS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249282" evidence="2">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB50447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="243" mass="28098" checksum="B562F7C8591F8FC8" modified="2015-04-29" version="1">MSKTWIGCCVVATLLLCSLGRQDSRVVEMSLCFSSVRDPLFRLNRDLLSQSVKAFLVRGTKTETLDGRISHLNIHSFHYQSKAPRILFMQINLLFSYRIYRIPHLTMYVKLYPKTMAKLTLLAASLLLTLSIVNVVAVSSSRKGLRGCEKFLTESCRRVRDDSCRERMKLCCGELECIEVQRRCSVIRRLVKELLEDFRSKQKREMLQKARNLPALCRMGIGRCDIRVPFPPSWFTKFAYVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYU7</accession>
    <name>A0A0D2PYU7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G0088002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYU7"/>
    <dbReference type="STRING" id="29730.A0A0D2PYU7"/>
    <dbReference type="Gramene" id="KJB12264">
        <property type="protein sequence ID" value="KJB12264"/>
        <property type="gene ID" value="B456_002G0088002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052981">
        <property type="entry name" value="Ingression_C2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052">
        <property type="entry name" value="CONSERVED SERINE PROLINE-RICH PROTEIN (AFU_ORTHOLOGUE AFUA_2G01790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47052:SF3">
        <property type="entry name" value="INGRESSION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="43" mass="4872" checksum="14F0A31D004A8EEF" modified="2015-04-29" version="1" fragment="single">MSVSGIHGHVLEVTVVGCNRLKDTEWLSRQDPYVCLEYGSTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q521</accession>
    <name>A0A0D2Q521_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G158900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q521"/>
    <dbReference type="STRING" id="29730.A0A0D2Q521"/>
    <dbReference type="Gramene" id="KJB11781">
        <property type="protein sequence ID" value="KJB11781"/>
        <property type="gene ID" value="B456_001G158900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796616"/>
    <dbReference type="eggNOG" id="ENOG502QPMF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMSLHTM"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF50">
        <property type="entry name" value="PECTIN LYASE-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249088" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="5">
        <location>
            <begin position="35"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="6">
        <location>
            <begin position="56"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="482" mass="52854" checksum="E32A97F9F42FE21B" modified="2015-04-29" version="1">MELLGMSPMRTKMTRIVTVLLLVGFILGVRGGEARKGKVTESFAYTGISCRRHTASITDFGGVGDGKTSNTKAFQDAVNHLSKYASDGGAQLYVPAGKWLTGSFSLTSHFTLYLQKHALLLASQDMKEWPVLKPLPSYGRGRDAAGGRFTSLIYGTNLTDVIVTGANGTIDGQGSFWWQKFHKGKLKYTRPYIIEFMYSDTIQISNLTLLNSPSWNVHPVYSSNILIKGIKILAPVKSPNTDGINPDSCTNVRIEDSYIVSGDDCIAVKSGWDEYGISFGMPTKQLVIRRLTCISPYSAAIALGSEMSGGIQDVRAEDITSVHTESGVRIKTARGRGGFVKDIFVRRMSLHTMKWVFWMTGNYKQHADNHYDPNALPVIQGINYRDIVANNVSMAARLEGIEGDPFTQICIANVTIGMAAKAKKVPWTCTDVEGITSGVSPRPCDLLPDQGQKKIAACDFPAEPLSIDRVVLKTCTYRVNHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q739</accession>
    <name>A0A0D2Q739_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_002G153600</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q739"/>
    <dbReference type="SMR" id="A0A0D2Q739"/>
    <dbReference type="STRING" id="29730.A0A0D2Q739"/>
    <dbReference type="Gramene" id="KJB14989">
        <property type="protein sequence ID" value="KJB14989"/>
        <property type="gene ID" value="B456_002G153600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785418"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAYCHER"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000015">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="1.10.510.10:FF:000249">
        <property type="entry name" value="Calcium-dependent protein kinase SK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="142"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="515"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="549"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="591" mass="66337" checksum="8FEC43CE2C311A66" modified="2015-04-29" version="1">MGNSCAKSAATEEDENEDNKQDGNEGEAKDPGQSESKEPEESGSVRKQPPEEMKIVREEDKTGKEQESKSTEKAAEMTQRQQSKSHPQRLNSKPSQLAGFNKEGSKTGNKTRKAHNVKRQSCAGLQVGSVLQTKTGHLKEYYNLGRKLGQGQFGTTFLCIEKGTGKEYACKSIAKRKLTTTEDVDDVKREIQIMHHLAGHPNVISIKGSYEDNMAVHVVMELCAGGELFDRIVKRGHYSERKAAEIARIIVAVVEACHSMGVMHRDLKPENFLFVNNEEDSPLKAIDFGLSIFFKPGDILNDVVGSPYYVAPEVLRKHYGPEADVWSAGVITYILLSGVPPFWGETEQEIFNEVLNGELDFSSDPWPNISESAKDLVTKMLDRDTKRRIKAHEVLRHPWVQVDGVAPDKPLDSVVLSRMKQFSAMDKLKKMALRVIAQRLSEEEIAGLKEMFKMIDADNSGQITYDELKEGLKRFGANLAESEFRALMQAADINNSGTIDYEEFVTATLHLNKIEREDNLLAAFSYFDRDSSGYITLDELQKACQEFGIQDIHLDEIMREVDQDNDGRIDYNEFVAMMQEGNPKLGKKGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAM7</accession>
    <name>A0A0D2QAM7_GOSRA</name>
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        <name evidence="1" type="ORF">B456_006G155100</name>
        <name evidence="2" type="ORF">Gorai_001076</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QAM7"/>
    <dbReference type="STRING" id="29730.A0A0D2QAM7"/>
    <dbReference type="Gramene" id="KJB36363">
        <property type="protein sequence ID" value="KJB36363"/>
        <property type="gene ID" value="B456_006G155100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799677"/>
    <dbReference type="eggNOG" id="ENOG502S17J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEMVYRT"/>
    <dbReference type="OrthoDB" id="1688863at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33148:SF46">
        <property type="entry name" value="EMB|CAB85509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33148">
        <property type="entry name" value="PLASTID MOVEMENT IMPAIRED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB36363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0587957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="162" mass="17863" checksum="E54797D0BFB2FE24" modified="2015-04-29" version="1">MGNCLVVEEKVIRIMEPDGKILEYQAPIKVEQVLSNFSGHALSDSFSGFHHLQPDAKLISGQLYYLIPLPSPSKKGKKKKVRFSNPEVNDDQVSSPNVVRIKLIISKQELQELLQNGGASAQDIASHNIQSKQTTNGIITPDVDDDSCRESKPVLQTIAEVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QDW4</accession>
    <name>A0A0D2QDW4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G010100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QDW4"/>
    <dbReference type="STRING" id="29730.A0A0D2QDW4"/>
    <dbReference type="Gramene" id="KJB17574">
        <property type="protein sequence ID" value="KJB17574"/>
        <property type="gene ID" value="B456_003G010100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787483"/>
    <dbReference type="eggNOG" id="ENOG502S2EA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KPWEEMT"/>
    <dbReference type="OrthoDB" id="1925898at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36347">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36347:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB17574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="189" mass="21034" checksum="011365D6452F93AF" modified="2015-04-29" version="1">MKMDSTILQSLASKSPPSTTPLFLQPPSSPPSQPPCTHLFFPRHRPRLPKLDCTNSSTDNSSTTSGNDTPPPPPPPPGEPIQIRFKRGSRRRRQLQEDGFGVQGQNMKTNKAAIEQPVPKKWEEKSMTEKALDLYVGEKGLLFWLNKFAYASIFIVIGAWILFRFVGPALNLYQLDSPPLAPTSMFKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGI0</accession>
    <name>A0A0D2QGI0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G148900</name>
        <name evidence="17" type="ORF">Gorai_011894</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RBR family. Ariadne subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="6"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGI0"/>
    <dbReference type="STRING" id="29730.A0A0D2QGI0"/>
    <dbReference type="Gramene" id="KJB57117">
        <property type="protein sequence ID" value="KJB57117"/>
        <property type="gene ID" value="B456_009G148900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771155"/>
    <dbReference type="eggNOG" id="KOG1812">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PQTEMPW"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000018">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000230">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="95"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="99"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00003976"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB57117.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0595013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="301" mass="34535" checksum="00C1EF00C036B87C" modified="2015-04-29" version="1">MAQITPSSDLDFVDDFYYSALFDEDEHEIFPPSDEKYAEELQFQEALMSSTVFSKMGNNDICNPCIAHASSPLLIQAVPLPELLEMETEETGESSLSFCEICAERKENDQMFITQSCNHSYCSDCISKHVSTRVEENLTVVRCPGVNCETVLELDECRPLLPEVVIHRWEDALCQEFISASQRFYCPFRDCSASLLNDGGEVIREAQCPFCHRLFCAQCCVPWHPGIACENFQRLNEYERGREDLMVRELAKENKWARCPKCKYYVERTAGCPHMVCRCQFEFCYGCGEKWSNTHGGCQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIJ7</accession>
    <name>A0A0D2QIJ7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="9">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_001G020900</name>
        <name evidence="15" type="ORF">Gorai_020361</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB07030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0578059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QIJ7"/>
    <dbReference type="Gramene" id="KJB07030">
        <property type="protein sequence ID" value="KJB07030"/>
        <property type="gene ID" value="B456_001G020900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801400"/>
    <dbReference type="eggNOG" id="KOG4629">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAWTMKI"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Predicted mechanosensitive ion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF20">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel protein Msy1/2-like transmembrane" evidence="13">
        <location>
            <begin position="141"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="12">
        <location>
            <begin position="538"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25886"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB07030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0578059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="715" mass="82209" checksum="B925C21B09B95FEA" modified="2015-04-29" version="1">MADKKEEVLINVSNEETPKVSKESEVLTPKHTANKPPKVPNAGNESHLTRRRSFTKPKSRFGEQSYLIESDQMEETNLATQEQLGSPYRHSFNKASPNIRTDSSVSKTFSMTSNGEKEYEEIIKKVKLHKEKLKGVKPKVVFEVVVFLILLGCLIASLALDKLQKTQIWGLHIWKWCVLVMVIFCGMLVTNWFMHLVVFLIEINFLLRKKVLYFVHGLKKSVQVFIWLSLVLLTWTLLFLGIERSKTATKILDKVTWTLVSVLIGSFLWLLKTLLLKLLASNFHMNKFFDRIQESVFHHYILKTLSGTPFMEIDGFQRSPTHLTVSKNKKGKEAKAKNVIDMGKVHQLKREKVSSWHMKVLVDAITNSGLSTISNTLDESVYKESGEQADKEITNEEEAQYVAHQIFSNVVCHESNQNCHYIDEDDLLRFMIKEEVELVFPLFEGSSTGKIDRKSFTNWVIKVYQDRKTLAHALSDTKTAVKQLNKLVTVVLIIVTVVIWLLLMEIATTKVLLLLSSQLVVAAFMFGNTCKTIFEAIIFVFVMHPFDVGDRCVVDGVQLLVEEMNILTTVFLKLDNEKVYYPNSVLATKPISNYYRSPDMGDTIEFSIDFMTPAKTIGRLKEEIKKHLEANTLWHPGHLVVVKEIENVNKLKMALFCTHTMNFQDFREKNRRRTELVLALKRIFEELGIRYNLLPQHVNFNQVNQDRPGTTYAIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLV9</accession>
    <name>A0A0D2QLV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G016400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="11"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLV9"/>
    <dbReference type="SMR" id="A0A0D2QLV9"/>
    <dbReference type="Gramene" id="KJB17810">
        <property type="protein sequence ID" value="KJB17810"/>
        <property type="gene ID" value="B456_003G016400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB17811">
        <property type="protein sequence ID" value="KJB17811"/>
        <property type="gene ID" value="B456_003G016400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB17812">
        <property type="protein sequence ID" value="KJB17812"/>
        <property type="gene ID" value="B456_003G016400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787555"/>
    <dbReference type="eggNOG" id="KOG1379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCHYSAI"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000138">
        <property type="entry name" value="5-azacytidine resistance protein azr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF56">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="133"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB17811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="375" mass="39998" checksum="9351DD54C5D7A374" modified="2015-04-29" version="1">MAVSGSKVVFGDVYVDELVSSCGNGFEFLKPKGVYFADRSHISCRKAGMVLRKQEQPLFVCGHYVSPTMSRNSKYNPPFGPRIKSSRTSPLPCSSSRAVHDVSFDGSSSDDQTTSLPLRAIPSERTLTLVSGSCYLPHPAKVEKGGEDAHFICADEQAIGVADGVGGWAEVGIDAGEFARELMSNSVKAIRDEPKGSVDPARVLEKAHSSTKSQGSSTACIISLHKEGLHAINLGDSGFIVVRDGSTVFHSPVQQHGFNFTYQLESGNNGDLPSSGQVFRIPILPGDVIVAGTDGLFDNLYNNEVAAVVVHALRAGFSPESTAKEIVALARERAVDKNKQTPFAKAAQDAGYRYNGGKLDDITVVVSFITSSPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QPL2</accession>
    <name>A0A0D2QPL2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G095500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QPL2"/>
    <dbReference type="STRING" id="29730.A0A0D2QPL2"/>
    <dbReference type="Gramene" id="KJB41223">
        <property type="protein sequence ID" value="KJB41223"/>
        <property type="gene ID" value="B456_007G095500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIEWEDC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.60">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023194">
        <property type="entry name" value="eIF3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21681:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB41223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="93" mass="10894" checksum="A9B61950201287F9" modified="2015-04-29" version="1">MTELFFKKGDDKTLYNFIPNSESDFVEYAELISHRLYPYEKSYHYIALLKAVMRLSLTSLKVADAKDIASSVTTILARFVKYIYFSIEWEDCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QPM8</accession>
    <name>A0A0D2QPM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2-carboxy-D-arabinitol-1-phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.63</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G008300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17837"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58008"/>
            <dbReference type="ChEBI" id="CHEBI:58185"/>
            <dbReference type="EC" id="3.1.3.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast stroma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.63" evidence="8"/>
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        <property type="protein sequence ID" value="KJB21679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QPM8"/>
    <dbReference type="STRING" id="29730.A0A0D2QPM8"/>
    <dbReference type="Gramene" id="KJB21679">
        <property type="protein sequence ID" value="KJB21679"/>
        <property type="gene ID" value="B456_004G008300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790002"/>
    <dbReference type="eggNOG" id="KOG0235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HDAVNKT"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0047538">
        <property type="term" value="F:2-carboxy-D-arabinitol-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative 2-carboxy-D-arabinitol-1-phosphatase"/>
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        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF10">
        <property type="entry name" value="2-CARBOXY-D-ARABINITOL-1-PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="KJB21679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="509" mass="55867" checksum="61C5B9391D870A04" modified="2015-04-29" version="1">MISLANAPLLLHGRDHHLPTKRRTPFTVRSSSSLQEIDKSPTTAEDSKLRSELCALVPFPPIKAAKRVVLVRHGQSTWNEEGRIQGSSNFSVLTKKGEAQAETSRQMLIDDSFDICFSSPLIRSKRTAEIIWGTREDEIITDSDLREIDLYSFQGLLKHEGKAKFGPAFRQWQVDAANFNIDGHYPVRELWGRARNCWTKILAHESKSVLVVAHNAVNQALVATAIGLGTEYFRILLQSNCGVSVLDFIPHPDGGSPLICLNRLNQTPGSPVATGSSAGRRTSRRIILVCQGSTQDSEATVSKLGDQQMNMLGVIQAQKTAELLLDLKVSTIISSPNNACAQTATIISQVQEAADCLGADCVPRYVEMKNIPDLDVAEIFQPSTKDTTDISYLRPGWLNGLDDTVTSALRERSGQAWHSLLTELSDESEEEKIVVAVAHPVAHIALIGHCLNLTEEWLGSFHLDAGSISVVDFPDGPTGRGIIRCINYTAHLGRWSIPITRSTVDDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQA9</accession>
    <name>A0A0D2QQA9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_003G085400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00400">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB19111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1495" mass="163655" checksum="08F2DEA23871FA8A" modified="2015-04-29" version="1">MKCRSVACIWSGTPPVHRVTATAALNHPPTLYTGGSDGSILWWNLSNSDSHSEIRPIAMLCGHAAPIADLAICCPIVVSGEQSMDYSSNVAFNSSFDNGGALLSACTDSMLCVWSRSSGHCRRRRKLPPWVGSPSIIRTLPWNPRYACVGCCFIDAAHLTDHQLMESAEGGEISMDKESQNRKPPKCTVVIVDTYTLTIVQTVFHGNLSIGPLKFMDVVSSVDDGEIHCSLLADSFGKLQLVPLSKDFHQGSEGETRLQKSSKQEIEAWEDGLVEAGQVVSIATCRTTVATVLKDRSIFRLLDGAITIGVILFMNNVLCVEDDHGQSHVVGAMFLESKNYGNAQITGVTHESEIFLVWNNRGSAVLYAISYLDNTFNYEPLCEIPATSFPLGARLSFSFVHLSQILLRVESVCFTIEDSFQWKPRVTIWSLQQRCDRGKLFDECKMLGQGISFLGWTPTAGLDRKSESLGGFNTKLTSIQSSVSVSETVDSIHVDDSCYSVPKGQTVSSSMVISENLYAPSAIVYGFSSGQIQVVWFNLFRGLDSPAGSPRLEVDSHISKQNFAGHTGAILCLAAHRMMGAAKGWSFSQVLVSGSMDCTIRIWDLDSGNLVTVMHQHVGPVRQIILPPARTERPWSDCFLSVGEDSCVALTSLETLRVERMFPGHPDYPAKLVWDGARGYIACLCRHHSRVSDAIDVLYIWDVKTGSRERVLRGTASHSMFDHFCKEISVTSISGSSLSGNTSVSSLLLPIHEDGNLSQHRLNSSESGVSLSKMTGSSTLLANNSKLNSGKAPFDSRTRKQPIKCFCPYPGIATLSFDLAALIDPCQKRKRISKNGDGRENSYIKEHLSEAFSPRHLNSDDGFNTDQSSTDAIEEHDWIKSLEEYLVRFSLSFLHLWDVDCGLDDLLIADIKLKRPNGFIVSSGLQGDKGSLTLTFPGFTSSLELWKSSSEFCAMRSLTMVSLAQHMISLSHPSSSASSALAAFYTRNFADKYPDIKPPLLQLLVSFWQDESEHVRMAARSLFHCAASRAIPAPLCSQQATKHAKLLRSLTGIEESENEISRKEETIVGLSSECLLETEGTSQVEKAKLLGWLESYEIQDWISCVGGTSQDAMTSHIIVAAALVIWYPSLVKPSLATLVVQPLVKLVMAMNEKYSSTAAELLAEGMESTWKACIGTEIPRLISDIFFQIECVSGPSANSAGENPAVPVSIRETLVGTLLPSLAVADILGFLTVIESQIWSTASDSPVHLVSLATLIRVVRSSPRSLVQYLDKVINFILQTMDPGNSVMRKTCHPRSMTTLREVIRVFPMVAMNESSTKLAFGDAIGEINGASIRVYDMQSATKIKVLDASGPPGLPSLLLRAPEMSVTTVISALSFSPDGEGLVAFSEHGLMIRWWSLGSVWWEKLSRNLNPVQCTKVIFVPPGEGFSPKTSRSSIMGSVLGHDTEAHSQEAAACYSDKLKLLIHNLDLSYRLQWVGERKVLLTRHGLEIGSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSD0</accession>
    <name>A0A0D2QSD0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ThiC-associated domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_003G124300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSD0"/>
    <dbReference type="STRING" id="29730.A0A0D2QSD0"/>
    <dbReference type="Gramene" id="KJB19911">
        <property type="protein sequence ID" value="KJB19911"/>
        <property type="gene ID" value="B456_003G124300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDWNKQF"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.540:FF:000001">
        <property type="entry name" value="Phosphomethylpyrimidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="entry name" value="Radical SAM ThiC family, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006763">
        <property type="entry name" value="PRK09284.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009895">
        <property type="entry name" value="PRK13352.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557:SF1">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="THIAMINE BIOSYNTHESIS PROTEIN THIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01114">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00113">
        <property type="entry name" value="Radical_SAM_Phosphomethylpyrim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB19911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="71985" checksum="A42DBDD4F5A6EC08" modified="2015-04-29" version="1">MASVHASFTSVVCKNGNHSAPSRFPCTTFLPGFDVVGRVSNACKKEICPSMSSGPKATLTFDPPTTNSEKSKQKKHTINPASPDFMPLPSFEECFPKSSKECREVIHEESGHVLKVPFRRVHLTGDVPNFDTYDTSGPQNINPRIGLPKLRKGWVDRREKLGAPRYTQMYYAKQGIITEEMLYCATREKLDPEFVRSEVARGRAIIPSNKKHLELEPMIVGRNFLVKVNANIGNSAVASSIEEEVYKVQWATMWGADTVMDLSTGRHIHETREWILRNSAVPVGTVPIYQALEKVNGIAEDLSWEVFRDTLIEQAEQGVDYFTIHAGVLLRYIPLTAQRMTGIVSRGGSIHAKWCLAYHKENFAYEHWDDILDICNQYDVALSIGDGLRPGSIYDANDTAQFAELLTQGELTRRAWEKDVQVMNEGPGHIPMHKIPENMQKQLEWCNEAPFYTLGPLTTDIAPGYDHITSAIGAANIGALGTALLCYVTPKEHLGLPNRDDVKAGVIAYKIAAHAADLAKGHPHAQAWDDTLSKARFEFRWMDQFALSLDPMTAMSFHDETLPSEGAKVAHFCSMCGPKFCSMKITEDVRKYAEEHGYGNPEEAMQHGMDAMSAEFLAAKKTVSGEQHGEVGGEIYLPASYVNSSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QT27</accession>
    <name>A0A0D2QT27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Disease resistance RPP13-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G067100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22819">
        <property type="protein sequence ID" value="KJB22819"/>
        <property type="gene ID" value="B456_004G067100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ILMNDAD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF51">
        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="7">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="6">
        <location>
            <begin position="187"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="8">
        <location>
            <begin position="445"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="9">
        <location>
            <begin position="707"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB22819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1398" mass="158712" checksum="948AF9C1DDC9C91F" modified="2015-04-29" version="1">MEAIASSLVEAVVSGMFRSLSDHFSSTHFNKFARKEKILSELKKWEILLLKINACLEDAEEKQSKSCSVKLWLRDLRDIAYAAEDIIDELAYEARRRQMKEDAGPSSSTHKMMRKYVSACCVNFNPSTLKFSTKVESKIKKLTARLEAAVAIKNDLSLEENDRGRRERVTERLRTSSLVEPRVYGREKDKEVILDILMNDADEGFGDIAVACIWGMPGVGKTTLAQLVYNDIKVESSFDLKIWVCVSEEFDVIRLTAIMLEAVTSASWNSKDLNLLQVSLKEKLSGKKFLLVLDDVWNENYEQWEALCKPFIAGAAGSKILVTTRNVDTASIMAPCGTYHLRELADKDCLSLFTRHALGGSDFDGHPNLKTFGEEIVKKCSGLPLAAKTLGGLLRTKRNSDEWEDIMNSKIWHLPEKGNSILPALLLSYHHLPSHLKRCFSYCAIFPKDYEFDKEELIRLWKAEGFLHHTKRKKQMEDIGIEYFRDLWSRSFFQQSTINKNRYAMHDLINDLAQFVSKEICFFNNGDKLNDGVKLESFRHFSFLRHQYDVSKRFEMLSQMTSLRTLVALPIHMLPMAASSFLTNTVLQQFVPKLGCLRVLSLNGYCIDELPHSIGDLIHLRYLNLSRTSIKSLPESVGSLFNLQTLILHGCKNLTKLPRAIENLIDLCVLDLTDTDSLKEMPMQIGNLKNLKVLSKFIVRRDSGSGIKELKGLLHLRKEISVIGLENVVDTGEARDYVLKDKNKLEGLHLQWGHESFDHRNGENGLPVFNMLQPHQDIKRVRVACYGGTKFPSWLGGSSMANIADINLSNCRNVMSLPALGRLPSLKKLSLTGMNGVKRLDFEFFGDNLPSSKPFPVLEVLQFQNMLNWEYWCYPNNRPDEEDREFPNLRELMIHNCPKLYQKLPRYLPSLVKLNIKGCPNMAYSVMSLPSLLDLSIEDCNKMVPRSMVDLTSLTTLRIKRVPDLTCLPNVFEQFPGALKHLSLSNCIGLTALWQKGNEQELEPNELHCLTSLEHLRIESCSELVSFPDIGFCPKLKRLQLRDFPWLKNLPCWIMKQGELTDCLIEDLEIEECPSLTSFPRGILPPTLKRLKIQDCICLCSLPDGLMQADNSKNTFCLENLEIISCPSLVRFPHGRLPTSLKMLKIWECLQLEPLSDRLLPNNASLEYIDIWNCPTLISLPDSLNNLKCLMELIIGNCQYLKYFPEIDLSLPNLKTLNISNCANLKSLPHQILNLTSLLYLTICNCPCIVSFPKGGLPPNLLSLEIWDCEQLKEPISNWNLHTSTSLKDLSIVGGPDLVSIPDEKCLLPTTLVSIYIAKLNNLESLSKGLLNLPSLEELEVVDCPKLRSLPREGLPTTLGRLRIRNCSLLKDQCSRERGEYWPLIASIPCVEIQSTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QU85</accession>
    <name>A0A0D2QU85_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CLAVATA3/ESR-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G224900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QU85"/>
    <dbReference type="Gramene" id="KJB10795">
        <property type="protein sequence ID" value="KJB10795"/>
        <property type="gene ID" value="B456_001G224900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250045" description="CLAVATA3/ESR-related protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB10795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8850" checksum="C35B8E389A200269" modified="2015-04-29" version="1">MKRVWKNHKVVFSLLLVTILLSMATSGSLLAEAKIPNFLAIQDSLKSGIQRRNLRPSPPGGGTSPIPNPPYRQEPPARYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXG4</accession>
    <name>A0A0D2QXG4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G425100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXG4"/>
    <dbReference type="Gramene" id="KJB62597">
        <property type="protein sequence ID" value="KJB62597"/>
        <property type="gene ID" value="B456_009G425100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S5VA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHPIEIG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35131">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35131:SF2">
        <property type="entry name" value="GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="12317" checksum="E7AEC350BA754B01" modified="2015-04-29" version="1">MQRSKSSGKNVAVDMAAHHPIEIGTKGTVGSLVMQEIKYFNRLELELSCRESSKKPHGRPIVGPVVAAEKKKKRGASKLVASICSVVEVSENRPVGVSGSGYRNLKSDSKKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2F1</accession>
    <name>A0A0D2R2F1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-galactosidase galactose-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G052400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Reddy U.K."/>
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                <person name="Zhang T."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
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                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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                <person name="Ashrafi H."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
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                <person name="Wang Z."/>
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                <person name="Lemke C."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RCU8"/>
    <dbReference type="SMR" id="A0A0D2RCU8"/>
    <dbReference type="STRING" id="29730.A0A0D2RCU8"/>
    <dbReference type="Gramene" id="KJB27481">
        <property type="protein sequence ID" value="KJB27481"/>
        <property type="gene ID" value="B456_005G165200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794477"/>
    <dbReference type="eggNOG" id="ENOG502S3UZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VIRVHIY"/>
    <dbReference type="OrthoDB" id="652307at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021775">
        <property type="entry name" value="DUF3339"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128">
        <property type="entry name" value="OS05G0103400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33128:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11820">
        <property type="entry name" value="DUF3339"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB27481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7439" checksum="CDDF859178C120D7" modified="2015-04-29" version="1">MADWGPVVIAVVLFVLLSPGLLFQLPGRNKVVEFGNMQTSGISILVHAIIFFGLITIFLIAIGVHIYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RER5</accession>
    <name>A0A0D2RER5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SBP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G135700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RER5"/>
    <dbReference type="SMR" id="A0A0D2RER5"/>
    <dbReference type="STRING" id="29730.A0A0D2RER5"/>
    <dbReference type="Gramene" id="KJB49738">
        <property type="protein sequence ID" value="KJB49738"/>
        <property type="gene ID" value="B456_008G135700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764019"/>
    <dbReference type="eggNOG" id="ENOG502QS71">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514967at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1100.10:FF:000001">
        <property type="entry name" value="Squamosa promoter-binding-like protein 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1100.10">
        <property type="entry name" value="Transcription factor, SBP-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044817">
        <property type="entry name" value="SBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004333">
        <property type="entry name" value="SBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036893">
        <property type="entry name" value="SBP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251:SF132">
        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31251">
        <property type="entry name" value="SQUAMOSA PROMOTER-BINDING-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26102">
        <property type="entry name" value="Ig_SPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03110">
        <property type="entry name" value="SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103612">
        <property type="entry name" value="SBT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51141">
        <property type="entry name" value="ZF_SBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="946"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="SBP-type" evidence="12">
        <location>
            <begin position="153"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="391"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="64"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB49738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="987" mass="109565" checksum="E691F0423A8825CF" modified="2015-04-29" version="1">MEVRVGNEARPFYGMMNPVGLPAVGKRTLEWDLNDWKWDGDLFIASSINPVSADSMGRQFFPIGSGIPGNSSNSSSSCSEEVNPETEKGKRELEKKRRVIVVEDDLPNQEAGSLSLKLGSQGGHGYPVSQRGMRNWEGTNGKKTKLSGGSGNRAVCQVEDCGADLSHAKDYHRRHKVCEMHSKASKALVGNVMQRFCQQCSRFHVLQEFDEGKRSCRRRLAGHNKRRRKTNPDAIVNSNSLNDEQTSGYLLLSLLRILSNMHSNRSDQTTDQDLLTHLLRSLASRTGEQGGKNMSGLLPEACDLEAVSALFSNGQGPPRPFKHHITGTASQIPHTGRQSCDTKGAEVPSNTAGAVKINNFDLNDIYIDSDDETDGIERSLAPVNAGTGSLDCPSWVQQDSHQSSPPQTSRNSDSASAQSPSSSSGDVQSRTDRIVFKLFGKEPNDFPLVLRAQILDWLSHSPTDIESYIRPGCIVLTIYLRQAEAAWDELRYDLSFSLSRLLHCSDDTFWRTGWICIRVLDQIAFIYNGQVVVDTSLPLGSNHYSKIMSVKPIAISATERAQFSVKGINLSQPATRLLCAVEGKYLVQEATHELMDDSDDLKEQDELECINFSCSIPNVIGRGFIEIEDHCLNSSFFPFLVAEDDVCLEIRMLESVLETTDTDADIGRCGKMEAKNQAMDFIHEVGWLLHRSQLKSRLGHLDPNPELFPLRRFKWLMEFSMDHEWCAVVKKLLNILLDGIVSSGEHPSLNLALTEMGLLHRAVRKNCRPLVELLLRFVPEKTSDRLGFENETVADGVHKSYLFRPDVIGPAGLTPLHIAAGKDGSEDLLDALTDDPGKVGIDAWKNARDSTGSTPEDYARLRGHYSYIHLVQKKINKRPPSGHVVVDIPSAVSDCSTNQKPNNESTSSFEIGQLELRSIKRNCKLCDQKLAYGYGTANRSLVYRPAMLSMVAVAAVCVCVALLFKSCPEVLYIFRPFRWELLDYGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF92</accession>
    <name>A0A0D2RF92_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G019700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF92"/>
    <dbReference type="STRING" id="29730.A0A0D2RF92"/>
    <dbReference type="Gramene" id="KJB17845">
        <property type="protein sequence ID" value="KJB17845"/>
        <property type="gene ID" value="B456_003G019700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787587"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IDDESTC"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000775">
        <property type="entry name" value="BnaA09g28200D protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045182">
        <property type="entry name" value="JINGUBANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF334">
        <property type="entry name" value="PROTEIN JINGUBANG-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="266"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="308"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="441"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="484"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB17845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="509" mass="56546" checksum="275F3867B90778A8" modified="2015-04-29" version="1">MLRFHCLPSFFILLHLGVTLFYGLPFRWIIYLGFVTSLFCMESIRVKKRGAFNVLFEETGSVVSRKLAKIKCSIAGEEEVKDSKGSSPTTSCDDNGGGSRLTNCNDYFSLGSSPSGDSTPSSYVNSPWSTTALVVYDSSIDDESTCSKELIGSLVREEGHVYSLAVIGDLLYTGSDSKNIRVWMKQKEFSWFKSRGGLVKAIVVVGNKIFTGHRDGKIRVWKVSTKMDNNGVHKRVGSLPTIRDYIKAAIQPRRYFETEPCRRDVWLRHTDAVSCLSFNEDKTLLYSASWDKTFKVWRVSDWKCLESVQAHDDAVNSIVVGCDGLVFTGSADGTVKVWRRELEGKGTMHLLSQTLLKQDCAITALAVSPASKFVYCGSSDGLVNYWECENHFSHGGAFRGHKLAVLCLVTAGNLVISGSADKSISIWKRTAGNEHRWLSTLKGHKGPIKCLAIEKDQESTENEWILYSGSLDKSVKIWRVSEEEQSIQSSNEIDSSDDKRTPTSSSSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGF0</accession>
    <name>A0A0D2RGF0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G041200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGF0"/>
    <dbReference type="Gramene" id="KJB18235">
        <property type="protein sequence ID" value="KJB18235"/>
        <property type="gene ID" value="B456_003G041200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DFFTREN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000125">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000333">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000842">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF436">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="978"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="638"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="954"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB18235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="997" mass="112888" checksum="A8EE6CB458F1FF26" modified="2015-04-29" version="1">MPAPDVVSWNSIITGYWQNGFLRESKKLFISMPDRNILSWNSMIAGCVENGYLDEAFQYFKAMPERNTESYNAMMSGFIRWDRVKEAEMLFQEMPRKNVISYTAMMDGYMKVGEFEKARALFDEMPYRNVVSWTVMISGYVDNGRFNEAKELYERMPNRNVVAMTAMITGYFKEGKVEDARTLFDGIWCKDLPCWNAMITGYALNGIGEEALKLCSEMVKLAIQPDIFTLVSVFTACSGLASVKEGRQMHVLVIKYGFESDASLCHSLINMYSKCGSILDAEQAFRQMNGACLVSWNTIISAFAQHGLCEKAVEFFNQMEVVGVKPDGVTFLSLLSACGHAGKVNESMDFFDLMVKEYGICPGPEHYSCLVDTLSRAGQLEKASEIIRSMPFEADAGVWGALLAACSVYLNVELGELAAKKIVEWNPHHSGAYVVLSNIYAAAGMWDEVTRVRLQMKEQGVKKQCAYSWMEIGNKVHHFLGGDISHPDTNKIHLEIKSISLQMKALAEKEASFRKLKQELVKSRLFESEAMNLLYQAKKRIQELEEEIERRKESEKKMHDSFVAQSKEHKQTQISLERSKQEIKLLLENLDKSEGSSEVASQGSVGDDHLERHEFELQLTKTNSARALEDERASSLKAKKLAEEVKSLKSQLRSTIEAEENNQKAMDDLALALKEVKSEGNETKEKHCLTIQELEKSKEEVENLKLQLKNVEAQYMEAKKEADRFNNTSERLRLEAEETLLGWNGKEKGFVECIRKAEDERNAAQEENKALLEALEESENMYKIAKEENQKLRDIMKQAINEASVAKEAASIAREENSQLKDTIAKKEEALNILSQENESLKINEAAAVENIRDLKLLFCEANWETEDHHEQRYHKRSRGPLSLTFPVRASDEDSSSDYSDDPLKGSIFDVAETPKSAPAAGSTPNGGTHQRKKSSSVLTDDEGMNGEEFEGIDTSHFDEEGDRSTRKKKALLRRFGDLIRRKNIPKKEQPLDQGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIG5</accession>
    <name>A0A0D2RIG5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Centromere protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G078100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIG5"/>
    <dbReference type="STRING" id="29730.A0A0D2RIG5"/>
    <dbReference type="Gramene" id="KJB70482">
        <property type="protein sequence ID" value="KJB70482"/>
        <property type="gene ID" value="B456_011G078100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB70487">
        <property type="protein sequence ID" value="KJB70487"/>
        <property type="gene ID" value="B456_011G078100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777793"/>
    <dbReference type="eggNOG" id="ENOG502QR44">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHRGNTE"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="352"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="368"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB70487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="708" mass="78886" checksum="276F4F254490E4AF" modified="2015-04-29" version="1">MPLPSDPLEAYSGLSLFPRTFASFPNPPPPYDPHDLQHLHHFLKSMPLQCPDKLMEQAKAIVDNSSELFNLDMSGSDAEVLENPRERRPALGRKRPRFSLKPNSSLPTVSLEPSIDIDKFKDPEEFFVAFEKAENAKREIEKQTGGVLMDLDQNIQSMAARPRRPGILRRSVKYKHRYSTPISPVESFEEEIPSPVCNSQPEKSDQNVELQEELSVTNAENKVNELLDHLLTSTCDGDEAISLLQEQLQIKPIDLEKICLPDLQDIRRIDLKASRENLAKPRNSLSDIENLFKGISKRTPKRKAESSVHLLASPTPPRSPLASISLLKKQKLQSDVLSDPFSADDVRRSPVRNASGTESNNRESVQVDTEKELSVSHNNDRRTPQQQPKSSAHHLASPTPPRDPLASISLLHKQMMLSDPESEPFSTDSIDQPPKRNASPIESVNKQSSQVHKKEQNNSHLLRSPLLEANQTATANASSELDGRDFAGLFDKFVNDNARSFDSGINVVSSGSQANLENNSLRRPEVASDSHTIKPNEFGGRVEDIPPEAVVSTQTQVNVEGLTIDNSGAIQKESDESSPAIDEDRSMDGSLKAAESGEQLLENMKGKIKRQPCNKHKGKKHSRRQSLAGSGTTFDPEGRRRSTRIRSRPLEFWKGERFLYGRVHSSLATVIGIKYESPEKGDGGNPTLKVKSFVSDEYKELIELAARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIV1</accession>
    <name>A0A0D2RIV1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_003G079600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIV1"/>
    <dbReference type="Gramene" id="KJB18995">
        <property type="protein sequence ID" value="KJB18995"/>
        <property type="gene ID" value="B456_003G079600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VICISRM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046948">
        <property type="entry name" value="ATL20-22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279:SF6">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="16">
        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB18995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="353" mass="39974" checksum="324D6834FA57109C" modified="2015-04-29" version="1">MGVDRCQTRYGYKEINFPFQLKNQPNEYRCRYPGLDVSCNNQTDTSIAFPSSGNFTAQIIGNVEQIIEIADPNGCLAKRLLEGFDLSGTPFLTVYLQNFMLLNCSNDVPFSTVSVSSLLNWEYLTDTMWLTWNEPDCKRCLKSGVCKYNKNTGFDDGCSVDLDPGSSNLAKYFAIFLAVSVFFIVGLVICISRMKCCLHKWRNTNTETFTYGSTILQSNAVKKGLDQRVIEMYPTMVVDTLKTIPSCMHYFHANCEFFLESLNGLFKLLLGTPVIVIVVCIVYYYVRVHCYDHGQHPNVEIFSLSAEQQLSSLPRPNDNTCSICLSEYQAKETIRTIPYSSHYFHANCMSGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RJ35</accession>
    <name>A0A0D2RJ35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G211500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RJ35"/>
    <dbReference type="Gramene" id="KJB31859">
        <property type="protein sequence ID" value="KJB31859"/>
        <property type="gene ID" value="B456_005G211500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000417">
        <property type="entry name" value="E3 ubiquitin ligase BIG BROTHER-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043312">
        <property type="entry name" value="AtBBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47530">
        <property type="entry name" value="E3 UBIQUITIN LIGASE BIG BROTHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47530:SF4">
        <property type="entry name" value="E3 UBIQUITIN LIGASE BIG BROTHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB31859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="332" mass="36725" checksum="DA38A7040E5925F5" modified="2015-04-29" version="1">MSAEQKEQEQEPNSNPNPNGNGNGNENLNTESEHEERQEDSQEQEQEQEREQPPRQSSTRTPFTNLSQVDADLALARTLQEQERAYMMLRMNNDGGSDYGSWEAGSYLHDDDDDDDFGDPHDHDITDGDDEDEDDGEQEDEDEEEYDGTDADDDEDAFDVHAHAEDGDEDNNPSAELDPAAFSSDEAFARALQDAEEREMAARLLALAGINDRGIFTLEDHGGHSQDTWEEVDPDELSYEELLALGEVVGTESRGLSADSLASLPSIKYKAGSSQTGSNDSCVICRVDYDDGDSLTVLSCKHSYHPECINNWLKINKVCPVCSVEVSTSGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKM0</accession>
    <name>A0A0D2RKM0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G238100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKM0"/>
    <dbReference type="Gramene" id="KJB32379">
        <property type="protein sequence ID" value="KJB32379"/>
        <property type="gene ID" value="B456_005G238100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000663">
        <property type="entry name" value="Vacuolar import/degradation Vid27-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055559">
        <property type="entry name" value="CYPRO4_DUF7135"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF7">
        <property type="entry name" value="DEM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23581">
        <property type="entry name" value="DUF7135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7135" evidence="3">
        <location>
            <begin position="52"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="298"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="633" mass="70238" checksum="37F96776BD5BB5F2" modified="2015-04-29" version="1">MGTSQSHEGGIIDSDCEEEEEEEEEEEEEEEEEEEAEEQYDDALGDHQKSGSSSGTHKGLDEIDAKLKSLKLKYSSYQQQGNPNLKNPVKLLLHIGGNTPKAKWVISEKLTSYDFVKTAKTNGNDDELDSAGWVLEVGSKVRVRVSTEMQMKMFGDQRRVDFVDKAVWALKFLSDYEYRNFVTLFQNCLFENAYGMEASEENKVKVYGKEFIGWVKPEVADDSMWEDAKDHSTDSAPFKGSRGSIEEFEEAANGGVRSLALGALDNSFLVNDIGVHVYRNLNRGINGKGICVKYDGGGNASNLTLKKTLLMRAETNIMLMSPANKGKPNATGLKQVDIETGKIVTEWKFEKDGTDITMRDITNDNKGSQMDPSESTFLGLNDKILCQWDMRDKKGMVQDIATSGSPVLHWTQGHQFSRGTNFQCFASTGDGSIVVGSLDGKIRLYSKASMRQAKTAFPGLGSPITQVDVTYDGKWVLGTTDTYLILICTLFTDKDGRTKTGFTGRMGNRIPAPRLLKLTPLDSHLAGNDNKFHGGHFSWVTESGKQERHVVATVGKFSVVWDFQQVKNTSHGCYRNQQGLKSCYCYKIVLKDESIVESRFMHDKYAGSDLPEAPLIVATPLKVSSISLSGSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLL2</accession>
    <name>A0A0D2RLL2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G146200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLL2"/>
    <dbReference type="STRING" id="29730.A0A0D2RLL2"/>
    <dbReference type="Gramene" id="KJB30485">
        <property type="protein sequence ID" value="KJB30485"/>
        <property type="gene ID" value="B456_005G146200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB30486">
        <property type="protein sequence ID" value="KJB30486"/>
        <property type="gene ID" value="B456_005G146200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0576">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCHILST"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="345" mass="37526" checksum="E90AB8C55DA1F4B7" modified="2015-04-29" version="1">MVKHKFIEKCKCGASVMLPKIEKAKRIRAAMAQQAQTTAPTIPGLNPPEGSNLNGDYGYTVPSKPQNMGLQVANQTPATGTLKKPRTLDGVEVTGEVGEFGTVIVHPGDELQKSFAQSQPHNGKEASTAIEHAERAVINGSRRQLIESQRGASATVTMEELQLTAKGSSPSIFVYPEQKLRSDSVPEARGKGSNQISSGTLKNETVSKKKAFALQDKLSSIYAAGNTVPIPFLRATDISPIALLSDNFLVGMYRDFSGTMALEALQELFAGDGQSKKGRRAQNEMQFPPSVYKRLASSPTLMNLAQALAYHKMCYDEMPLQELQATQEQQTIQNLCDSLRTILRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RS30</accession>
    <name>A0A0D2RS30_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-rich protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G013700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RS30"/>
    <dbReference type="STRING" id="29730.A0A0D2RS30"/>
    <dbReference type="Gramene" id="KJB53963">
        <property type="protein sequence ID" value="KJB53963"/>
        <property type="gene ID" value="B456_009G013700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZUD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAGDNDQ"/>
    <dbReference type="OrthoDB" id="1931102at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132">
        <property type="entry name" value="OSJNBB0118P14.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33132:SF53">
        <property type="entry name" value="SERINE-RICH PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB53963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="22446" checksum="2356103B57EA85BF" modified="2015-04-29" version="1">MAASSRKSSGPVLRSLSPSGRFSSHYVSHSPSSSSSAFAYSSSSFTSRSSTFFNQPRSISPPRVNVYNHTQSSQSVRFSLDSRPISPNRSISAVRRNTEALRNLQSKQPKRTCMCSPTTHPGSFRCSLHKGFNNSHASSGYAPSNRLNARRSAMTNSLVRIGGVEGDLVKRALSALIRPSSHQQRRRAAFQPRPSRLSVMSKAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTH9</accession>
    <name>A0A0D2RTH9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Glutathione S-transferase 3, mitochondrial</fullName>
            <ecNumber evidence="15">4.4.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutathione peroxidase MGST3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">LTC4 synthase MGST3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_004G047600</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione</text>
            <dbReference type="Rhea" id="RHEA:75963"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:85236"/>
            <dbReference type="ChEBI" id="CHEBI:194498"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:75964"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>leukotriene C4 = leukotriene A4 + glutathione</text>
            <dbReference type="Rhea" id="RHEA:17617"/>
            <dbReference type="ChEBI" id="CHEBI:57463"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:57973"/>
            <dbReference type="EC" id="4.4.1.20"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:17619"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="14">Lipid metabolism; arachidonate metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Lipid metabolism; leukotriene C4 biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.4.1.20" evidence="15"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTH9"/>
    <dbReference type="SMR" id="A0A0D2RTH9"/>
    <dbReference type="STRING" id="29730.A0A0D2RTH9"/>
    <dbReference type="Gramene" id="KJB22440">
        <property type="protein sequence ID" value="KJB22440"/>
        <property type="gene ID" value="B456_004G047600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790394"/>
    <dbReference type="eggNOG" id="ENOG502S4E5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACQHLGW"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004464">
        <property type="term" value="F:leukotriene-C4 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006691">
        <property type="term" value="P:leukotriene metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.550:FF:000004">
        <property type="entry name" value="Microsomal glutathione S-transferase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF22">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0564">Palmitate</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00039056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00051411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00069748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00076908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB22440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="16163" checksum="34E106240C3F9F6B" modified="2015-04-29" version="1">MEFLAKEYGYVALVVVAYCFLSIWMGIQVGMARKKYKVYYPTLYALESENKDAKLFNCVQRGHQNSLEMMPMFFVLMILGGMAHPCISAALGLFYTVTRYFYFTGYSTGDPQKRLTIGKYGFLALLGLKICTISLAINLLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RU77</accession>
    <name>A0A0D2RU77_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G287300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RU77"/>
    <dbReference type="STRING" id="29730.A0A0D2RU77"/>
    <dbReference type="Gramene" id="KJB74317">
        <property type="protein sequence ID" value="KJB74317"/>
        <property type="gene ID" value="B456_011G287300"/>
    </dbReference>
    <dbReference type="OMA" id="IMEIFVI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053258">
        <property type="entry name" value="Ca-permeable_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34115">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34115:SF13">
        <property type="entry name" value="RPB1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB74317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="320" mass="36533" checksum="862631FBFEAFC4A4" modified="2015-04-29" version="1" fragment="single">RALKFPRSERAILASKRRRMSPGHIPSLRINNNNSITSFSFLMVVFLALINLKFQPLRNIESPFETQGVVMPMFVICMLVYSITFCTPYFPEVIDHINLLAGSLATVLLTFTLFPSLGRVILFIWTIHFVKLIYGAIPKLCQLCQALPSLLNLRVLLGRHAHHNEERCCNNHIHASLGFLISVLVDLIQVKYQSTNMAVPFETHPAIMFIFITAILVYAAAATIKTSNDNSSVHRVIVTKISLLTGSLATVVLVLVIVPPIGWFILLIWTFFLVKQIYYGCQMLRQPYRIISVVYYVIYQIFGRRRDMNQGRNRLSLFMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUT3</accession>
    <name>A0A0D2RUT3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GDSL esterase/lipase 7-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G002200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUT3"/>
    <dbReference type="STRING" id="29730.A0A0D2RUT3"/>
    <dbReference type="Gramene" id="KJB33226">
        <property type="protein sequence ID" value="KJB33226"/>
        <property type="gene ID" value="B456_006G002200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797362"/>
    <dbReference type="eggNOG" id="ENOG502SIKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSKACKE"/>
    <dbReference type="OrthoDB" id="1530612at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051238">
        <property type="entry name" value="GDSL_esterase/lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650:SF24">
        <property type="entry name" value="GDSL ESTERASE_LIPASE 7-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45650">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266869" description="GDSL esterase/lipase 7-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43016" checksum="9A8289C33F74A325" modified="2015-04-29" version="1">MVKLHLCVFIILIYLLEFGLSDVIEVPPLNINQKDLMKHLSLIDIKIALPAIYVFGDSFVDNGNNKAILGNKDAIGGGYLPFGIDFDGKPTGRVTNGRIGVDFIATVAGLPYPPPIMGMSKIDRKRIQTGVNYASGSSGLLPQNGHFLHKNVINFFQQVDLFENTTMEDLKGKFDSYKGFTQYLSKSLFFIHHAGNDLGLTFEAEMAKKYSIDKYAKLLIKEFSKQLKRLYTLGARKFFVSNVSPLGCSPFSINTKNHSGPCVEEINNRVSIYNELLPSLLKNLQSTLSGSKFVLGDIYKVFKDVFEMPESYGFKDVNTSCCIDNNGTKIQVCAPNIAPCKDRKTRVFFDPFHPSETMHFLWARRFLKDSSVCSPINLIQLMQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RW41</accession>
    <name>A0A0D2RW41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G076500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RW41"/>
    <dbReference type="STRING" id="29730.A0A0D2RW41"/>
    <dbReference type="Gramene" id="KJB55443">
        <property type="protein sequence ID" value="KJB55443"/>
        <property type="gene ID" value="B456_009G076500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RY0R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TGWFDIQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04216">
        <property type="entry name" value="Phytocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000048">
        <property type="entry name" value="Early nodulin-like protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF6">
        <property type="entry name" value="EARLY NODULIN-LIKE PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phytocyanin" evidence="2">
        <location>
            <begin position="80"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB55443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="278" mass="30941" checksum="D213BA32F4035ABA" modified="2015-04-29" version="1">MTCYSDSERNSKATYINHNFSYSIALKSPTSIQSTKTHYRNSRNMGQSSGYNYSTSVLQLITIVSCLVVLSCSGSVSAYKNYTVGGSLGWFDALEKPDVNYQKWADSKNFSLGDFLIFNTDNNHSVIQTYNFTTYKFCDYDDALQNDTIEWSATDPSSTAPHPISVAVPLLKEGMNYFFSSDYDGEQCNNGQHFKINVTHGQGLPKSLDPSDDAPAPNSPDYRGDDSAPETIVPANFNHPIEEESDKDEASGSGSVYFNTKFYGLLIFLQIVCIFFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RWB7</accession>
    <name>A0A0D2RWB7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G096300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RWB7"/>
    <dbReference type="STRING" id="29730.A0A0D2RWB7"/>
    <dbReference type="Gramene" id="KJB23400">
        <property type="protein sequence ID" value="KJB23400"/>
        <property type="gene ID" value="B456_004G096300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CAYFPME"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040256">
        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025558">
        <property type="entry name" value="DUF4283"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF99">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14111">
        <property type="entry name" value="DUF4283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4283" evidence="1">
        <location>
            <begin position="2"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="176" mass="20431" checksum="EEEA5DD7662EB5F5" modified="2015-04-29" version="1">MDLENDYYLVRFSEEDDYNKVLTNGPWVIFGQYLTIRPWTPDFLTTQDEGRFVRIAICVDLRKPLISKVRINGHLQRVEYESLPHVCFKYCLYGHGSDLCQKGCAYFPMEDDPVNMAMLEKLGCQDLNRRVKEEDYGLWMLVECRKWCTGRSLGVKVNDIQGRQNGGSRFEALGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RX34</accession>
    <name>A0A0D2RX34_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G043700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB34011.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="OS05G0103400 PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB34011.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12246" checksum="64963D72A5A2096F" modified="2015-04-29" version="1">MDSAHHPLLRHQENPKPYIKYKVLKEKLDKEREMSLLSNADWGPIVVAVVLFILLSPGMMFQLPTRTRVIEFGNMCTSGIAILVHAIIYFSLFTILIMAIGIHIHVY</sequence>
</entry>
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    <name>A0A0D2RXZ7_GOSRA</name>
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        <name evidence="15" type="ORF">Gorai_001238</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2RXZ7"/>
    <dbReference type="Gramene" id="KJB36779">
        <property type="protein sequence ID" value="KJB36779"/>
        <property type="gene ID" value="B456_006G177400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36783">
        <property type="protein sequence ID" value="KJB36783"/>
        <property type="gene ID" value="B456_006G177400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB36784">
        <property type="protein sequence ID" value="KJB36784"/>
        <property type="gene ID" value="B456_006G177400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0700">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000008">
        <property type="entry name" value="Phosphatase 2C family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="31"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB36784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0588125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="371" mass="41092" checksum="37D607ABCF846CCB" modified="2015-04-29" version="1">MVKSCWNPSAEGDSGGRVDGLLWCKDLGQHMYGEFSMAVIQANSMLEDQSQIESGPLSSTTSGPYGTFFGVYDGHGGTEASRYVNDNLFSNLKSFASEHQEISADVLRKAFSTTEENFLSLVRKQWHVKPHMASVGSCCLIGIICNGLLYIANAGDSRVVLGRSGRGTKQAKAMQLSVEHNASIDTVREELRSLHPNDPHIVVKKHRVWRVKGLIQISRSIGDAYLKKAEFNKEPLLPKFRLPEPFQKPILSAEPSVLVHKLHPDDQFLIFASDGLWEHISNQEAVKIVQTSPRNGIARRLIKAALKEAAKKREMRYSDLRKIDRGVRRHFHDDITVVVVFIDPNLINGGSSSYFPLSIKGGRFAAGAGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2D0</accession>
    <name>A0A0D2S2D0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G129400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wang Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="EMBL" id="KJB79582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23175" checksum="9415ACAF3CDE1F93" modified="2015-04-29" version="1">MARSGDPQGDGGEPVLPRASSSTRLRSRPDPFLVVCRCFSVITSLTAILCIAVNVLSAVRSFKNGADVFDGIFRCYAVVIAFFVVLAETEWGFIIKFWKVLEYWAGRGMLQIFVAVMTRAFPDYTERQKDLVLLQNIASYMLLACGVVYVFSGILCIGFLKRSRQQKEITREQAVQDLEVSYESCSKLAFWSTSCLDDFLSMYSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SA98</accession>
    <name>A0A0D2SA98_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Superoxide dismutase</fullName>
            <ecNumber evidence="6 13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G293300</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="6 13"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SA98"/>
    <dbReference type="STRING" id="29730.A0A0D2SA98"/>
    <dbReference type="Gramene" id="KJB60198">
        <property type="protein sequence ID" value="KJB60198"/>
        <property type="gene ID" value="B456_009G293300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770420"/>
    <dbReference type="eggNOG" id="KOG0876">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HQTYVTA"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="121"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB60198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="230" mass="25695" checksum="D520EC4325E5902A" modified="2015-04-29" version="1">MALRSLATRKTLTLALKSTRLAQSRALQTFSLPDLPYDYGALEPSISGEIMQLHHQKHHQTYITNYNKALEQLHDAIQKGDSSTVVKLQSAIKFNGGGHINHSIFWKNLAPISEGGGEPPHGSLGWAIDTNFGSLESLIQKMNAEGAALQGSGWVWLGLDKELKKLVVETTTNQDPLVTNGPNLVPLLGIDVWEHAYYLQYKNVRPDYLKNVWKVINWKYASEVYEKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDF9</accession>
    <name>A0A0D2SDF9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G035700</name>
        <name evidence="2" type="ORF">Gorai_017877</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0589112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2SDF9"/>
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        <property type="protein sequence ID" value="KJB39881"/>
        <property type="gene ID" value="B456_007G035700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802034"/>
    <dbReference type="eggNOG" id="ENOG502QW45">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPPKDSY"/>
    <dbReference type="OrthoDB" id="783877at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37181">
        <property type="entry name" value="F6A14.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37181:SF1">
        <property type="entry name" value="F6A14.6 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB39881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0589112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="391" mass="43618" checksum="B07553756547CA51" modified="2015-04-29" version="1">MTLLDVITKASASTGPHTSQADHPIVLNTDDIFFNLKPEVENPNPTSLVNPLTGWGISQTDAKFIDLSKKFYTKLNRNLKDIHNFNKEEFIGILNPFLEKIKEKGRIFIGVDPNDTGYTSVLLEKVGFLIGRDVLSLVLEACISLEIWELLEVLIVNGLVDHSCYPNLVVNIAAKKRSDLLCLCVKHARNLGSVELLCILKYFLCPPKDSYVSMVNVRKDWESQALLAIEKAKLGKKSPLAKEASILLMVAYDGFLDPELCLHYLLASNNVDEVILSSLLGKLVGKELINLIRYLGKWLKKYERFPQAIPCPKASSALGLKACDWVPKVEDVAKCLGFVVDENFSSLMLHPKFCEELKSIEGVVSSLAFEARFCCSMANVIEKLRAEDIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJR3</accession>
    <name>A0A0D2SJR3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G189700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2SJR3"/>
    <dbReference type="Gramene" id="KJB31400">
        <property type="protein sequence ID" value="KJB31400"/>
        <property type="gene ID" value="B456_005G189700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794734"/>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATPCKIF"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47434:SF1">
        <property type="entry name" value="PROTEIN PTST HOMOLOG 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47434">
        <property type="entry name" value="PROTEIN PTST HOMOLOG 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="449"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="389"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB31400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="525" mass="58774" checksum="FFD1F86F7B39BA57" modified="2015-04-29" version="1">MATFTSSTYTFVSPHSFLTHFRARVFPSCFCGINPGNKGNSVSLKLNLVRGLVFGEDKKRVSWWSCCCKKGWDNDGDLALEADILEFMKNSDKPEAFPSKKELVDAGRMDLVEGIKRQGGWLAMGWDLDDDDEHGFQEKGFPEAGVKDWDLLEKEKKWDNQTFQERAQSEVEISGASYLAVNSSSSTSSSGRSLEVAAKDDCGVEGILSRLERERNVNFGIGFRDKGDNTCPQTNCTEEESLVQASTDVTVGGPHRRKLMSFSGSSGLGNDTTAKFIQDQPLSGIDGLRNPTWREWSLQRAGIAGKEFEDISGYGTLEIRNKSNELDRRKESRASGKDINHNEIRDRLEHLKLELSSVLQSLRSNVDEVLSREGDESSIDNFHKLSDASEFQENEISNAQDKLRSLRARLAVLEGKMTLAIIDAQKTVEEKQKRIDDARRALQLLRTACIVWPNSGSEVLLAGSFDGWATKRKMEKSSTGVFSLQLKLYPGKYEIKFIVDGEWKLDPLRPIVNNNGFENNLLIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SL39</accession>
    <name>A0A0D2SL39_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G280300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SL39"/>
    <dbReference type="Gramene" id="KJB44934">
        <property type="protein sequence ID" value="KJB44934"/>
        <property type="gene ID" value="B456_007G280300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267336" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB44934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11778" checksum="5B12B8A8E79EFF9E" modified="2015-04-29" version="1">MITLWAIILLEEMMPCNCLHYRSYLRLDLLVALNCASTGILSYANILRDKLQLLEQDEIGNWMFSCYLSMEHLTKDDARQKFLLLWTLLIGFRFLSCLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SL71</accession>
    <name>A0A0D2SL71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="7 15">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ADP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G163700</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2 15">This protein plays a role in synthesis of starch. It catalyzes the synthesis of the activated glycosyl donor, ADP-glucose from Glc-1-P and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 15">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 15">Heterotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Plastid</location>
            <location evidence="3 15">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 15">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="7 15"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SL71"/>
    <dbReference type="SMR" id="A0A0D2SL71"/>
    <dbReference type="STRING" id="29730.A0A0D2SL71"/>
    <dbReference type="Gramene" id="KJB42681">
        <property type="protein sequence ID" value="KJB42681"/>
        <property type="gene ID" value="B456_007G163700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803384"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYHEASM"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00152"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02508">
        <property type="entry name" value="ADP_Glucose_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04651">
        <property type="entry name" value="LbH_G1P_AT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000010">
        <property type="entry name" value="Glucose-1-phosphate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000030">
        <property type="entry name" value="Glucose-1-phosphate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002772">
        <property type="entry name" value="PRK02862.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523:SF12">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE LARGE SUBUNIT 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="GLUCOSE-1-PHOSPHATE ADENYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25247">
        <property type="entry name" value="LbH_GLGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="12 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 15" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="16">
        <location>
            <begin position="90"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB42681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="518" mass="56596" checksum="5BDA20E23A27AC63" modified="2015-04-29" version="1">MVSMAAIGDLRLPSTASFNASSVCSSRKSSAPRSLSFSASALSGDKLVFKIATGCSRTERTASIVSPKAVSDSKNSQTCLDPDASRSVLGIILGGGAGTRLYPLTKKRAKPAVPLGANYRLIDIPVSNCLNSNISKIYVLTQFNSASLNRHLSRAYASNMGGYKNEGFVEVLAAQQSPENPNWFQGTADAVRQYLWLFEEHNVLEFLVLAGDHLYRMDYERFIQAHRETDADITVAALPMDEKRATAFGLMKIDEEGRIIKFAEKPKGDQLKAMQVDTTILGLDDERAKEMPFIASMGIYVVSKDVMLNLLRDQFPGANDFGSEIIPGATSIGMRVQAYLYDGYWEDIGTIEAFYNANLGITKKPVPDFSFYDRSSPIYTQPRYLPPSKMLDADVTDSVIGEGCVIKNCKIHHSVVGLRSCISEGAIIEDTLLMGADYYETDADRRFLSAKGSVPIGIGKNSHIKRAIIDKNARIGDNVKIINSENVQEAARETDGYFIKSGIVTVVKDALIPSGTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNC0</accession>
    <name>A0A0D2SNC0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G201200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNC0"/>
    <dbReference type="STRING" id="29730.A0A0D2SNC0"/>
    <dbReference type="Gramene" id="KJB43461">
        <property type="protein sequence ID" value="KJB43461"/>
        <property type="gene ID" value="B456_007G201200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803780"/>
    <dbReference type="eggNOG" id="ENOG502QQGA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12030">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12020">
        <property type="entry name" value="Uncharacterised protein family UPF0261, NN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009215">
        <property type="entry name" value="TIM-br_IGPS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051353">
        <property type="entry name" value="Tobamovirus_resist_UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056778">
        <property type="entry name" value="UPF0261_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002674">
        <property type="entry name" value="PRK02399.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31862:SF1">
        <property type="entry name" value="UPF0261 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G10120)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09370">
        <property type="entry name" value="PEP_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23189">
        <property type="entry name" value="UPF0261_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="2">
        <location>
            <begin position="6"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="UPF0261" evidence="4">
        <location>
            <begin position="208"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="TIM-barrel" evidence="3">
        <location>
            <begin position="484"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB43461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="752" mass="80024" checksum="48BB99407D4141B5" modified="2015-04-29" version="1">MGITAKVFCVGTADTKLDELHFLSQSVGSSLTTFSNSSSSKVEVVIVDVSAGQKETESSGDFKFVTRKELLLCYSESVGGNPIALPDDRGEAVDIMSKALQHFIKKAHADGVLAGAIGLGGSGGTSLLSSAFRSLPVGVPKLIVSTVASGQTEPYVGTSDLVLFPSIVDICGINSVSRVVLSNAGAAFSGMVIGKLEKFQESCNEGKKCTVGITMFGVTTPCVNVVNERLKNEGYETLIFHATGVGGKTMESLVREGYIQGVLDITTTEVADYVVGGVMACDSSRFDVIIEKKIPLVLSVGALDMVNFGAKDTIPSHFQQRKIHIHNAQVSLMRTTVDENKKFAAFIADKLNKSSSKIVVCLPQKGVSALDASEKPFYDPEATGTLLNELQRLIQINEDRQVKMYPYHINDPEFAKALVDSFMEICSKNPTDSSLPQVASCESSQDLQKGHDHNVSSSSSGTLTYSPSNFPDARPETLQRTQGILQQLRDQISKGLPIVGAGAGTGISAKFEEAGGVDLIVLYNSGRFRMAGRGSLAGLLPFADANAIVLEMANEVLPVVKAVPVLAGVCGTDPFRRIDYFLKQLESIGFSGVQNFPTVGLFDGNFRQNLEETGMGYGLEVQMIAKAHKMGFLTTPYAFNTNEAVEMAKAGADIIVAHMGLTTSGSIGAKTAVSLEESVLRVQAIADAAHAINPNVIVLCHGGPISGPSEAEFILKRTKGVHGFYGASSMERLPVEQAITSTVQQYKSISIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUF9</accession>
    <name>A0A0D2SUF9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G041400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUF9"/>
    <dbReference type="Gramene" id="KJB47779">
        <property type="protein sequence ID" value="KJB47779"/>
        <property type="gene ID" value="B456_008G041400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QU92">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCPRAYY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000002">
        <property type="entry name" value="probable WRKY transcription factor 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31429">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31429:SF54">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="8">
        <location>
            <begin position="294"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="230"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB47779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="505" mass="56094" checksum="9B7F59E4615D865C" modified="2015-04-29" version="1" fragment="single">KSLLTFFLNKIIGLKLGSHPTIKTSLLLTRPCGKGIDFGGSILRENKGLDDVEEINLTDQNWEMEMDLSLKIDSKEKEEDMEESMDSKMQVEEAEAAEDKEVTSMAAAGEVEDVDAPLELSLQGNNKTHELSVLQLEMNRMKEENKELRKVVEKTMQDYYDLQMKFAVIQKNDHKQDPPIFLSLNGNGNGNGNSSQDQQPIQRNLNIGNHQKHGPSEGDHNDEKNEEELGLSLRLQISSSQREREEEHNKEGSEETPNVASEQNKLQPTCLSAITSHAVSPPNRKARVSVRARCQTATMNDGCQWRKYGQKIAKGNPCPRAYYRCTVAPGCPVRKQVQRCLEDMSILITTYEGTHNHPLPVGATAMASTASAAADSFMFLDSSNPLSNGIPNLSQASLPYQNHPHLMKSHRNVMNFTDPSKGTILDLTNNRHVNHHFPTASSSSSHHPSPAFPWMPSRLSNGTSSRQWKSQEDKSLAENVTAIASDPKFRVAVAAAITSLINKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVE6</accession>
    <name>A0A0D2SVE6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystatin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G187300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVE6"/>
    <dbReference type="Gramene" id="KJB67373">
        <property type="protein sequence ID" value="KJB67373"/>
        <property type="gene ID" value="B456_010G187300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772195"/>
    <dbReference type="eggNOG" id="ENOG502S46Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFAITEH"/>
    <dbReference type="OrthoDB" id="2016588at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00042">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000010">
        <property type="entry name" value="Cystatin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046350">
        <property type="entry name" value="Cystatin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018073">
        <property type="entry name" value="Prot_inh_cystat_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47364:SF2">
        <property type="entry name" value="CYSTEINE PROTEINASE INHIBITOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16845">
        <property type="entry name" value="SQAPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00043">
        <property type="entry name" value="CY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54403">
        <property type="entry name" value="Cystatin/monellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00287">
        <property type="entry name" value="CYSTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018701919" description="Cystatin domain-containing protein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Cystatin" evidence="4">
        <location>
            <begin position="28"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB67373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="119" mass="13417" checksum="4BAFE20020063803" modified="2015-04-29" version="1">MQQNSRFLLLSLSLLFLPFIFSDAKKGPIIGGWTRIKDIKDPHVTEIAEFAVNEYNKLSSSSLVLQKVVKGETQVVAGINYRLVLKAKNGSVAKKYQAVVWEKSWLNFRNLTSFTLVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVJ9</accession>
    <name>A0A0D2SVJ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_008G056100</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVJ9"/>
    <dbReference type="STRING" id="29730.A0A0D2SVJ9"/>
    <dbReference type="Gramene" id="KJB48189">
        <property type="protein sequence ID" value="KJB48189"/>
        <property type="gene ID" value="B456_008G056100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763147"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQPAFRL"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF228">
        <property type="entry name" value="CYTOKININ HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB48189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="59486" checksum="C37EC94C27531259" modified="2015-04-29" version="1">MAAMVVFLITLSVLFMIFLVFKLVFDTISCYLLNPRRIRKTMEKQGVRGPKPRGVTGNMLEMFKLTSQSTSKEMGTIHHDLVGRLLPHYVKWSKSYGKRFIYWHGVEPRMCLTDTELIKELMTKHHLVTGKSWLQQQGSKHFTGRGLLMANDRDWYHQRHIASPAFMGDKLKSYCGHMVESTKQMLQSLQNAVNSGQTEFEIGAYMSRLTADIIARTEFDSSYEKGKQIFYLLTSLQHLCAQASRHLCFPGSRFFPTKYNREMKSLKMEVDRLLMEIIQSRKDCVEIGRSSSYGNDLLGILLNEMEKKRGDQFKLNLQLIMDECKTFFFAGHETTALLLTWTVMLLATNPSWQDKVRAELKEVCNGGVPSVDQLSKLSVLHMVINESLRLYPPATVLPRMAFENIKLGDLFIPKGLSIWIPVLAIHHSEELWGKDVNEFNPNRFNSRPFTSGRHFMPFAAGPRNCIGQSFAMMEAKIILSMLISRFSFTISQSYRHAPVVVMTLKPKHGVQVHLKPLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SX41</accession>
    <name>A0A0D2SX41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquinol-cytochrome c reductase complex 6.7 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G219300</name>
        <name evidence="2" type="ORF">Gorai_008280</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SX41"/>
    <dbReference type="SMR" id="A0A0D2SX41"/>
    <dbReference type="STRING" id="29730.A0A0D2SX41"/>
    <dbReference type="Gramene" id="KJB67953">
        <property type="protein sequence ID" value="KJB67953"/>
        <property type="gene ID" value="B456_010G219300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S99R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RPQPTDI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB67953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0598523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="57" mass="6390" checksum="D67715DBA55CE943" modified="2015-04-29" version="1">MAGERALFKFLKPGQRLQPADVQAAAMWGVAATTGALWLIQPFDWLKKTFLEKPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXN4</accession>
    <name>A0A0D2SXN4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G092800</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
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                <person name="Grover C."/>
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                <person name="Romanel E."/>
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    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T340"/>
    <dbReference type="STRING" id="29730.A0A0D2T340"/>
    <dbReference type="Gramene" id="KJB70108">
        <property type="protein sequence ID" value="KJB70108"/>
        <property type="gene ID" value="B456_011G058200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778579"/>
    <dbReference type="eggNOG" id="ENOG502QWFY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SFQRACM"/>
    <dbReference type="OrthoDB" id="680041at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039621">
        <property type="entry name" value="BG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541:SF28">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33541">
        <property type="entry name" value="PROTEIN BIG GRAIN 1-LIKE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB70108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0599190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45488" checksum="3725561D2E021BAC" modified="2015-04-29" version="1">MDTWDKMVREERYRTKTENPSFSSSLLDAIYRSIDESNGGGKRNEDLIFCRETSSMRKKQSNNSSSSSSFQRACMIEKWMEKKENKVFVTPKSMADFDDPVLLNSSSTSSDSSYGGGFSSSESDSFYSAKSRSSSSYHCHRLPKPIRTSTISAPKHEVFQNNFHGATQKSKHEGSFIKTKSKALKIYSDLKKVKQPISPGGRLASFLNSLFTSGNAKKTKISSSKTEQATSTCSSASSFSRSCLSTTKTPSSRGNVGTKRSVRFCLDEDSRPCGETKILHENELRTSMRKPVNKELEYRIMEENRRVAEAAKELYNSYQKKKIKEELYMRGIIYNGNEVLSDDETSAAAAAAIADDDDDDIASDASSDLFELDNLSAIGSNERYSEELPVYETTHLDTNRAIANGLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T3D2</accession>
    <name>A0A0D2T3D2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G238800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T3D2"/>
    <dbReference type="STRING" id="29730.A0A0D2T3D2"/>
    <dbReference type="Gramene" id="KJB38080">
        <property type="protein sequence ID" value="KJB38080"/>
        <property type="gene ID" value="B456_006G238800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3424">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QGKQMVI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="181"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB38080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="206" mass="23733" checksum="22C976F55BABCD77" modified="2015-04-29" version="1">MCTIVDVVHILQLDHSQSFYFSIFEISILVQMIVVNLLTGFNFSAGAFHYPPPQAERRSKSISTFKEPQLKAMADKAVTIRTRKFMTNRLLSRKQFIIDVLHPGRPNVSKAELKEKLARMYEVKDQNSIFVFKFRTHFGGGKSTGFGLIYDSVENAKKYEPKYRLIRNGLDTKVEKSRKQMKERKNRAKKVRGVKKTKAGEAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5J9</accession>
    <name>A0A0D2T5J9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G3415002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the REF/SRPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB38895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5J9"/>
    <dbReference type="Gramene" id="KJB38895">
        <property type="protein sequence ID" value="KJB38895"/>
        <property type="gene ID" value="B456_007G3415002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008802">
        <property type="entry name" value="REF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33732">
        <property type="entry name" value="REF/SRPP-LIKE PROTEIN OS05G0151300/LOC_OS05G05940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33732:SF9">
        <property type="entry name" value="REF_SRPP-LIKE PROTEIN OS05G0151300_LOC_OS05G05940"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05755">
        <property type="entry name" value="REF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB38895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="756" mass="78376" checksum="F8993C7406BB66A4" modified="2015-04-29" version="1">MSPGGSGERSPQAQNSGLLGTASGFIKQVSSDAISTAQSSPGVATKAQHSGLFGAASGLIKQVSSDAISAAHNVATDVQHAGLIGESLSNIDRLAPPVIKNVSSKAISAVQNVPGVVTEVGNGGLLNTATGILKQVSSDAISAAQGVATEVHHVGAIGESLAKIDNLVPSVIKQVSSDAISANQKVAGVATGLGSLVQHGGILSTASGLIKDVSSQAISAAQGVVSELKHGGVVKEETEKLKYLAFLQLAIIHVILWFGNLYTKLKQMSGPLKPVIEIVERMVKTLIGPIFETFFDSLYDLFKFADDWIGEFVTKIDGILPPVIKQAISKVTSAANNALGLTVDVPTMEVQSTGVKSTSSRFLQQISSGAILVVEGVASQAKNSGLIPEELQVLKYLKYLKYFVTVQAAVLRAVKFYFQVKKMLRPLRPVIDFIERVVVSVYQKIFAKMVKSLFRWVLVNLFGVPAGVFDIIDKVGGDLSKLGDLSNLGDLCTLGDFSTLGGLSKLGDLSKIDDLVPSGALSAVQSLPGVGGLATGLPGTGLLSSASGLLKPVSSNAIPGAQMVADVHHAGTVEATTKIDSLISPLFKRSSKVTSVAQKTLGMATGSATGFIKQISSGAISAAQKAPRVAQGLSNAGVQNTGSLTQLASKPIAATQKPAEVQHSGVVKGASTLAKSVFTVVEPTVEKCAVSIWQTLNKIPLFPQVASVVVPTAAFFTDKYNQTVATGAEKGYKVALILPVVPTQKIAKVFSVGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T803</accession>
    <name>A0A0D2T803_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">S-protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G162700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant self-incompatibility (S1) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T803"/>
    <dbReference type="Gramene" id="KJB71803">
        <property type="protein sequence ID" value="KJB71803"/>
        <property type="gene ID" value="B456_011G162700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S6K9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEDYQFG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060320">
        <property type="term" value="P:rejection of self pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010264">
        <property type="entry name" value="Self-incomp_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35630">
        <property type="entry name" value="LEGUMINOSIN GROUP486 SECRETED PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35630:SF1">
        <property type="entry name" value="LEGUMINOSIN GROUP486 SECRETED PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05938">
        <property type="entry name" value="Self-incomp_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0713">Self-incompatibility</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB71803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15297" checksum="559630AA7951A320" modified="2015-04-29" version="1">MDGRSSYVLFLVSVFIFSVAGRLGLGKRIATVHVTNSMPRELQPIQLGCNSRYKNHGMHQLHVGEDYQFGVEEKALHFCEAISGRQIASWHAYQPRRDWNHKAVFWRVKENGFFLSWDNSSWVRKSIWQTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8J5</accession>
    <name>A0A0D2T8J5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G152000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T8J5"/>
    <dbReference type="STRING" id="29730.A0A0D2T8J5"/>
    <dbReference type="Gramene" id="KJB71983">
        <property type="protein sequence ID" value="KJB71983"/>
        <property type="gene ID" value="B456_011G152000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EWDIKIK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF241">
        <property type="entry name" value="XYLOGLUCAN GALACTOSYLTRANSFERASE GT14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="7">
        <location>
            <begin position="94"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB71983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="527" mass="61016" checksum="4719519F9CFF493C" modified="2015-04-29" version="1">MENPITSKCCNHQPWFVLLVFFVFCIELFSFDYSGFTAKKSALVTVLDDNHGTVINTQSSLPHDFTEITNASVYPLPKTDEKGDLKVGTEIDSCVGRYIFVHDLPSRFNEDLVNNCRLLTRGTDKNMCPYLDNLGFGPEIENPEDVLINNSWFLTNQFLLEVIFHNKMKRYECLTNDSSIASAIYVPFYAGLDMSLYLWGFNTTVRDSASLGLVKWLSEKPEWKRMWGRDHFLVAGRIAWDFRRQSDNETDWGSKLRFLPESKNMSMLSIESSSWNNDYAIPYPTCFHPSKDSEIFRWQDRMRRQNRQYLFSFAGAPRPEYQNSIRGKIIDQCLASKSQCKLLDCNYGTTNCDNPVNVMKVFQSSIFCLQPPGDSYTRRSIFDSILAGCIPVFFHPGTAYAQYIWHLPKNYTAYSVYLPVKDLSEWKINLNETLLRMPEDRILRLREEVIKLIPRVVYASSRSRSETLEDAFDLAVKGILDRIESVRVMIREGKDPSIGFADGDDYKYTFSTYDTSMLNHFKIFHMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCU9</accession>
    <name>A0A0D2TCU9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Growth-regulating factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G259500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription activator.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The QLQ domain and WRC domain may be involved in protein-protein interaction and DNA-binding, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GRF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCU9"/>
    <dbReference type="Gramene" id="KJB52381">
        <property type="protein sequence ID" value="KJB52381"/>
        <property type="gene ID" value="B456_008G259500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765356"/>
    <dbReference type="eggNOG" id="ENOG502QVQ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="841551at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031137">
        <property type="entry name" value="GRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014977">
        <property type="entry name" value="WRC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31602:SF3">
        <property type="entry name" value="GROWTH-REGULATING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08879">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51667">
        <property type="entry name" value="WRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="7">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="WRC" evidence="8">
        <location>
            <begin position="201"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB52381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="458" mass="50007" checksum="E02C383248F3A5E7" modified="2015-04-29" version="1">MDTRNNAFVGTEKGLGRTDEGCDVGLGLMMMQQVEESCPNKSFMAMLPPHNHNHLSSSSSSSCYVEGFDGGASGGGPLVCNTSNQEPCRGDIYDVVGAASASVSSAAAAVVLKSLHHHSFSADPPFPHHSSVGEMAAAPVNARVPFTAAQWQELERQTMIYKYMMASVPVPAELLIPLTKNPSNVAIKGSLELGFSSNSSDPEPWRCRRTDGKKWRCSRDVAPDQKYCERHSHKCRPRSRKPVELPNHSNININNNDHKSQTLHNMASDGTTNQPHQNPHFTNHHDPHFFTSSFDQSRCLEWFMKGETTVPFASNPEWQRTNYGVSLQAQHHLNEQFTPSLASLEGSLNLNQTHSQETRAFIDAWSIAEREVVELEGIGSCKRPVSSNEKLPLSSLTLSMSGGGNENTQEEDDENSHHEMRGTLSWMGSSPGGPLAEALCLGIATSQTTSTSSCSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCY3</accession>
    <name>A0A0D2TCY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial inner membrane protein OXA1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G261000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC (TC 2.A.9.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCY3"/>
    <dbReference type="STRING" id="29730.A0A0D2TCY3"/>
    <dbReference type="Gramene" id="KJB52416">
        <property type="protein sequence ID" value="KJB52416"/>
        <property type="gene ID" value="B456_008G261000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF34">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB52416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12975" checksum="16424D415DCBBC22" modified="2015-04-29" version="1">MQGNPAAATIKNVSRVFAVLTVPFTMSFPKAIFCYWITSNLFSLGYGLVLKVPGVKKALGVPEIPKQPVVTAPRPSIDLYTALKQAKTASQQSTSLPIEPTEVANQITSSSSRPSIRGLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TE16</accession>
    <name>A0A0D2TE16_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G129100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB41930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_007G129100"/>
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        <property type="term" value="C:chloroplast"/>
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    <dbReference type="GO" id="GO:0010270">
        <property type="term" value="P:photosystem II oxygen evolving complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Protein LOW PSII ACCUMULATION 1, chloroplastic"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021883">
        <property type="entry name" value="LPA1-like"/>
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    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047558">
        <property type="entry name" value="TPR_END_plus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35498">
        <property type="entry name" value="PROTEIN LOW PSII ACCUMULATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35498:SF4">
        <property type="entry name" value="PROTEIN LOW PSII ACCUMULATION 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF3493"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB41930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="448" mass="50042" checksum="E54593C46AC14E24" modified="2015-04-29" version="1">MAVAALALNQQLLCFSYPKIRAKSRPWFPQKTTLLNSQKKPHIFIVSCSSSPTSQSPEANVQTAESCVNLGLSLFSKGRVKDALVQFETALSLDPNPVEAQAALYNKACCHAYQGEAKKAAECLRTALRDYNLKFGTILNDPDLASLRASPEFKELQEEYLLSFQARLGGEDIGYSFRRDLKLISEVQAPFRGVRRFFYVAFSAAAGISLLFTVPRLFRAIKGGDGAPDIWETVGNAGINIGGIIVLVALYFWDNKKEEEQLAQISRNETLSRLPLRLSTNRIVELVQLRDTVRPVILAGKKESVSSALQKAERFRTELLRRGVLLVPVIWGEGRTPQVEKKGFGVSKKAATALPSIGEDFEKRAQSITAKSKLKAEIRFKAEVISLEEWERWIRDQQESEGVTPGEDVYIILRLDGRVRRSGKGMPDWSQIVQELPPMEALLSKLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TEX2</accession>
    <name>A0A0D2TEX2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G285700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TEX2"/>
    <dbReference type="STRING" id="29730.A0A0D2TEX2"/>
    <dbReference type="Gramene" id="KJB74298">
        <property type="protein sequence ID" value="KJB74298"/>
        <property type="gene ID" value="B456_011G285700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776300"/>
    <dbReference type="eggNOG" id="ENOG502QU51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEMPGYS"/>
    <dbReference type="OrthoDB" id="1929779at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055028">
        <property type="term" value="C:cortical microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043622">
        <property type="term" value="P:cortical microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949">
        <property type="entry name" value="GASTRIC MUCIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31949:SF20">
        <property type="entry name" value="OS01G0141900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB74298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="583" mass="61304" checksum="5D0779B6F8760CFD" modified="2015-04-29" version="1">MNRSFRAQQETAMQTAALKQRQQLRASMMKDKEEELALFLEMRKREKEQSSFLNHCSEDFDAPLGSIPGTSPIFNLSASATAPARKMGGAADDFLNSESDKNDYEWLLTPPGTPLFPSLESQKTVMSQIGAPKASPTVLKSRLANPQPESAARSNLSPKQPALSSGLNSTGIRRPSSSGGPGSRPATPTGRPTLTGASKPTRSSTPTSRATLTSTRSSSSAAKPVTSAAKPAISATKSATKPVVHTTKPTVSAAKSASSTKPTVSARSATPTRSTARSSTPPARPSIPSSKPVSRAATPTRRPSSAANVSAPPIKSSPSVTKPTPSASRNPVPSRGGASPVVKSRPWKPSEMPGFSHDAPPNLRTTLPDRPLSATRGRPGAPSSRSSSVEPAPAGRPRRQSCSPSRGRLPNGSMLHVSGCSVPAISRGYSKVSDNVSPVVIGNKMVERVINMRKLVPPKQDDKHSPHGNLSVKSSSPDSSGFGRTLSKKSLDMAIRHMDIRRRIPCNLRPLMTNIPASSMYSVRSGPTRSRNISVSDSPLATSSNASSELSVNNNGICLDGSEIEDDIGSEIGGRSPASMHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TLY0</accession>
    <name>A0A0D2TLY0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G098900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TLY0"/>
    <dbReference type="STRING" id="29730.A0A0D2TLY0"/>
    <dbReference type="Gramene" id="KJB76663">
        <property type="protein sequence ID" value="KJB76663"/>
        <property type="gene ID" value="B456_012G098900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780634"/>
    <dbReference type="eggNOG" id="KOG0034">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46971">
        <property type="entry name" value="CALCINEURIN B SUBUNIT (PROTEIN PHOSPHATASE 2B REGULATORY SUBUNIT)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46971:SF4">
        <property type="entry name" value="OS08G0442300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB76663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="175" mass="19729" checksum="B59E2D5B51032F1C" modified="2015-04-29" version="1">MGNTSSMLTQYDIEEVQQHCNNAFSQQEIVSLYERFCQLDRNGGGFVSGEEFLSVPEFAVNPLSQRLLTMLDGLNFKEFVAFLSAFSPRATVQQKIEFIFKVYDSDGNGKVTFNDMLDVLHDLTGQFISEQQREQVLTKVLEEAGYTKESLLVMSDFVKILGSSGLKMEVEVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TP26</accession>
    <name>A0A0D2TP26_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G217300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TP26"/>
    <dbReference type="STRING" id="29730.A0A0D2TP26"/>
    <dbReference type="Gramene" id="KJB58594">
        <property type="protein sequence ID" value="KJB58594"/>
        <property type="gene ID" value="B456_009G217300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769721"/>
    <dbReference type="eggNOG" id="KOG1339">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYGTHFQ"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05476">
        <property type="entry name" value="pepsin_A_like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000025">
        <property type="entry name" value="Aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000030">
        <property type="entry name" value="Eukaryotic aspartyl protease family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034161">
        <property type="entry name" value="Pepsin-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF895">
        <property type="entry name" value="EUKARYOTIC ASPARTYL PROTEASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251921" description="Peptidase A1 domain-containing protein" evidence="9">
        <location>
            <begin position="29"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="86"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="636" mass="70992" checksum="86FF71F9AB667372" modified="2015-04-29" version="1">MARTWLHLTSSFLIVCCVIGFLISTVVAENHQRPPTVLPLSLSSRNHSLHRHVDNLRRRLFQSKLSGSTPNARLRLYDDLLSNGYHTARLRIGSPPQEFALIVDTGSTVTYVPCSSCSHCGNHQDSRFQPEMSSTYQPVKCNPSCNCDDEQKQCTYHRRYAEMSSSSGVLGEDLVSFGNESELMPQRAVFGCENVETGDLYNQRADGIMGLGRGRLSIMDQLVDKGVIGDSFSLCYGGMDVDGGAMVLGKIAPPPDMVFSHSDPFRSPYYNIEMKEIHVAGKRLELPDGAFDGRHGTVLDSGTTYAYFRRDAFAAFRDAILSAVHFLKRIPGPDPNYNDICFTGAGRDVSQLPKIFPQVEMVFNNGKKLLLSPENYLFRHSKASGAYCLGIFPNSESTTLLGGIVVRNTLVTYDRSNDRIGFLNTNCSELWRRVQFSGAPAPTPLVSPSKDTKMEIPSVLSPSGSPSNVLPGSFHVGFITFDMSISTTDSNLKSILKELTELISEELEVDNSQIRLLNVTSQEKDYLVRWGIFPAEPANYISNTIARSIILRLRDHRIQLPERFGNYKLMEWNAEPQRKLTSWQHRFLIMLVGSVTTLILSLSAIGIWLVHRQRQQTAYEPVGASVPERYLQPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQE2</accession>
    <name>A0A0D2TQE2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallothionein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G322600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallothionein superfamily. Type 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQE2"/>
    <dbReference type="STRING" id="29730.A0A0D2TQE2"/>
    <dbReference type="Gramene" id="KJB45705">
        <property type="protein sequence ID" value="KJB45705"/>
        <property type="gene ID" value="B456_007G322600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761278"/>
    <dbReference type="eggNOG" id="ENOG502S7B3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SENDCKC"/>
    <dbReference type="OrthoDB" id="994877at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044671">
        <property type="entry name" value="MT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33357">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33357:SF3">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB45705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="6708" checksum="A74728715F9A0557" modified="2015-04-29" version="1">MSGTCGNCDCADRSQCTKKGNSNTMIVETEKSYINNVEMDAPAENDGKCNCGTGCSCTDCTCGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U180</accession>
    <name>A0A0D2U180_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G370200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U180"/>
    <dbReference type="STRING" id="29730.A0A0D2U180"/>
    <dbReference type="Gramene" id="KJB61616">
        <property type="protein sequence ID" value="KJB61616"/>
        <property type="gene ID" value="B456_009G370200"/>
    </dbReference>
    <dbReference type="OMA" id="MANNWTA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000101">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053211">
        <property type="entry name" value="DNA_repair-toleration"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060">
        <property type="entry name" value="DNA DAMAGE-REPAIR/TOLERATION PROTEIN DRT100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48060:SF21">
        <property type="entry name" value="L DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268230" evidence="12">
        <location>
            <begin position="22"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="78"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB61616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="193" mass="21686" checksum="6A0E94B3AA5A28E1" modified="2015-04-29" version="1">MDYNTCFHLLLALFIPCSVLCLAMTVKNLNSNQFALLKFKDRVAGPQNDMANNWTASTSVCNWIGVSCGILHKRVIALNLTSMNLRGTIPPHLGNLSFLLSLDLSSNHFYGHLPKEFGQLHRLRILQLSYNRLNGEIPSWLGNLQRVRRLEMKNNNFTGTIPETLVNMSNLEILNLGFNQLSGQVPSSIFNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2Z9</accession>
    <name>A0A0D2U2Z9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G172000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2Z9"/>
    <dbReference type="STRING" id="29730.A0A0D2U2Z9"/>
    <dbReference type="Gramene" id="KJB82003">
        <property type="protein sequence ID" value="KJB82003"/>
        <property type="gene ID" value="B456_013G172000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783010"/>
    <dbReference type="eggNOG" id="ENOG502QSY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2018059at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032001">
        <property type="entry name" value="SAWADEE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039276">
        <property type="entry name" value="SHH1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33827">
        <property type="entry name" value="PROTEIN SAWADEE HOMEODOMAIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33827:SF7">
        <property type="entry name" value="PROTEIN SAWADEE HOMEODOMAIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16719">
        <property type="entry name" value="SAWADEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="3">
        <location>
            <begin position="13"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB82003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="375" mass="41962" checksum="CDB86C27452B9CBA" modified="2015-04-29" version="1">MGRHPSSGGPAFRFTQTEVAEMETILQEHHNQMPVREILMSLADKFSESAERKGKIVVQFKQIWNWFQNRRYAIRAKSNKVPGKLNITSMPRDDSNPMRNVPQPVAAPVPPHMTAPMPASTVPGAGRNLSESYMEFEAKSSRDGAWYDVATFLAHRYLDAGDPEVQVRIAGFGPEEDEWVNIRKHVRQRSLPCEASECVAVLPGDLVLCFQEGKDQALYFDAHVLDAQRRRHDIRGCRCRFLVRYDHDQSEEIVPLRKVCRRPETDYRLQQLHAASNLSNHQHKTSTDQSTALTPKIIGSSTEAMQKLQNPDQSRTATDSHFNVSVAAQTTNQESKILGIVTTDVTDPRISPVKNAMAAAATGIGPGQNVQEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4Y7</accession>
    <name>A0A0D2U4Y7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4408 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G449400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4Y7"/>
    <dbReference type="Gramene" id="KJB63016">
        <property type="protein sequence ID" value="KJB63016"/>
        <property type="gene ID" value="B456_009G449400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1PA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYFKFYF"/>
    <dbReference type="OrthoDB" id="1727102at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34947">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34947:SF2">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB63016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="25432" checksum="DF2B5AD96875A1E9" modified="2015-04-29" version="1">MDQTGNQKQKQSLSQFIETQFHINLTQLLLSVSIFSLFFSHSYCLSLFHSFSFTFHNTLAFKFISHNIDKNFIFLLCNGILVFLAKFSGLISSSSQHSNLSDDHYNHQSFKSYTYIPQTPLLELEKEENAGFVEEEAKGSSIDEPFVEDNEESEAYEPEEEEEEDIEESENYEPEEEELMEGNNVLSTEEMNKRFDEFIRKMKEGLRIEAQQQLVMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8U5</accession>
    <name>A0A0D2U8U5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_N0136001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204169">
        <property type="protein sequence ID" value="KJB84253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U8U5"/>
    <dbReference type="Gramene" id="KJB84253">
        <property type="protein sequence ID" value="KJB84253"/>
        <property type="gene ID" value="B456_N0136001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LRILWIT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF67">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="3">
        <location>
            <begin position="10"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="4">
        <location>
            <begin position="182"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="5">
        <location>
            <begin position="305"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB84253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="595" mass="69046" checksum="DFA8820BAA51B7B1" modified="2015-04-29" version="1" fragment="single">RCDDLTLEALQARLRSLLNYKKFLLVLDDVWNENQAKWVELRNLLRSTDGFSPSKIIVTTRSLNVASLMSSIPPCMLKGLPLEDCLTLFTKWAFNDGDERHYPNLIRIGEEIVKKCKGVPLAVRTLGSLLFQKTDESDWIYIRESEIWRLEQHENDILPVLKLSYNHLPSHLQRCLAFLSFYKKDEIYYSDRVIRLWMANGLLEHPKQNQEWEDVGKRYLNELLSRCLIQMEEDYWLYFTFKMHDLVHDLALDVSQKECKTVNSETETVDENVRHLLLCDGKLVGVPLIIQDASKESKTTHESLINLCLSNFKYLRALVLRKSPLTALPNSIGTLKHLRDLDLGVCMSLRELPRSFDKLRSLQSLNLGDTGLKQLPDSVQRLIELRHLVITIQATHLKEIRAGCWTSLQYLELRYCMELECLPEGMQYLKSLRTLILSYCLSLVSLPRSLKLLTKLEHLEIVGCFQINLKIELEEEEDKDLQLSLKTLSLLGLHALRDLPRLLLQGSSSTLQQLRIAFCPDLSVLPAWLPNLTSLQKLEIEHCVNLWDLPEGIDRLTNLRELRIYGCPELSKRYRENGGEDWNKISHIQKVDIYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL35</accession>
    <name>A0A0D2UL35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transmembrane protein 184C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G021900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UL35"/>
    <dbReference type="STRING" id="29730.A0A0D2UL35"/>
    <dbReference type="Gramene" id="KJB69394">
        <property type="protein sequence ID" value="KJB69394"/>
        <property type="gene ID" value="B456_011G021900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69395">
        <property type="protein sequence ID" value="KJB69395"/>
        <property type="gene ID" value="B456_011G021900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776539"/>
    <dbReference type="eggNOG" id="KOG2641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHHHWLD"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB69394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="33675" checksum="2E0A17073666FEB7" modified="2015-04-29" version="1">MDLSHLNRGQITRIGSGFCVLLTLHFTFQLLAQHLFHWKNPKEQKAIVIIIFMAPIYAVVSFVGLLDVRGSKEFFTLLESIKECYEALVIAKFLSLMYSYLNISISKNIVPDEIKGREIHHSFPMTLFQPRTVKLNHGTLKLLKYWTWQFVVIRPVCSILMITLQTLRVYPSWLSWTLTIILNVSVSLALYSLVVFYHVFAKELAPHKPLAKFLCIKGIVFFCFWQGVVLDILVAMGFIKSHHHWLDVEHIEEALQNTLVCIEMVVFTVVQRRAYSAAPYSGESEAKIKKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMD6</accession>
    <name>A0A0D2UMD6_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G047400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Streptophyta</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMD6"/>
    <dbReference type="Gramene" id="KJB69869">
        <property type="protein sequence ID" value="KJB69869"/>
        <property type="gene ID" value="B456_011G047400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB69869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="101" mass="11729" checksum="3BDF82E6F510DB5E" modified="2015-04-29" version="1">MAIINIGALSKKIGDREQKVLKNKKRHQLQYIIYLINPTSIYIETAIAYSCYQMGFLLQKILPQHKPKKGKKKTESIHGLHQMYVHDNYMTARGSSLLRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URF1</accession>
    <name>A0A0D2URF1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein MIZU-KUSSEI 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G111600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URF1"/>
    <dbReference type="STRING" id="29730.A0A0D2URF1"/>
    <dbReference type="Gramene" id="KJB71224">
        <property type="protein sequence ID" value="KJB71224"/>
        <property type="gene ID" value="B456_011G111600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775075"/>
    <dbReference type="eggNOG" id="ENOG502QSCG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="672310at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010274">
        <property type="term" value="P:hydrotropism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006460">
        <property type="entry name" value="MIZ1-like_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01570">
        <property type="entry name" value="A_thal_3588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696:SF4">
        <property type="entry name" value="OS08G0171800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31696">
        <property type="entry name" value="PROTEIN MIZU-KUSSEI 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04759">
        <property type="entry name" value="DUF617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27383" checksum="5157E4276E44FB83" modified="2015-04-29" version="1">MADSRPNTGNDNSRDGSTAPPPNPSTPKASSSPQPFSLIQPSELQSKKQKRKVLRAFRSVFRAFPIITPACKFPTSPGLQTDSHISISGIRVTGTLFGYRKGKVSLSIQESPKCLPSLVIEFSLQTNVLQKELSAGMVRIALECEKRCGKEQVKLFDEPLWTMFCNGKKTGHGVKREATAEDLHVMELLKAVSMGAGVLPGNSETEGVDGELAYIRAFFDRVVGSKDCETLYMLSPDGNTGPDLCIFLVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXK6</accession>
    <name>A0A0D2UXK6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G242200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2UXK6"/>
    <dbReference type="Gramene" id="KJB73651">
        <property type="protein sequence ID" value="KJB73651"/>
        <property type="gene ID" value="B456_011G242200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776844"/>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="17687at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="TBC1 domain family member 8B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000018">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
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    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
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    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="250"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="52"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="641"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="711"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="745"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="820"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="858" mass="96631" checksum="901EE2507D7F8973" modified="2015-04-29" version="1">MRSSSSTAAAATISTTNKGVNPVIAFEHKRDAYGFAVRPQHVQRYREYANIYKEEEEERSDRWNDFLERQAESAQLPVNGRPSEEGKETSHAAEDGDSEVKKGTEKDDLCERKSGSDNLSENDTEKEKVQSAPEKKVHRIQIWTEIRPSLQAIEDMMSVRVKKKCILSKDEQKTSQGKPLTPTEDARSPKGASEEDSDDEFYDAERSDPVQDSPTSGSGSTRTGGGADDAAPTESLFPWKEELEVLVRGGVPMALRGELWQAFVGVRARRVENYYQDLLANETNCGNNTEQQRLQSDSKGSTTESIGGPEKWKGQIEKDLPRTFPGHPALDDDGRNALRRLLTAYARHNPSVGYCQAMNFFAALLLLLMPEENAFWTLMGIIDDYFDGYYSEEMIESQVDQLVFEELVRERFPKLVNHLDYLGVQVAWVTGPWFLSIFMNMLPWESVLRVWDVLLYEGNRVMLFRTALALMELYGPALVTTKDAGDAVTLLQSLAGSTFDSSQLVLTACMGYQNVNEKRLHDLREKHRSAVIAAVEERSKGLQAWRDSQGLASKLYNFKQDPKSMIMETNKTKANGDLSHSESGSTNSDEVLISLTGDADTGAVPDLQEQVVWLKVELCRLLEEKRSAVLRSEELETALMEMVKQDNRRQLSARVEQLEQEVAELRMALSEKQEQENAMLQVLMRVEQDQRVTEDARRFAEQDAAAQRYAVQVLQEKYEEATASLAEMEKRVVMAESMLEATLQYQSGQSKVQPSPRSSHPDSSARSNQEPQQEIPARKISILSRPFGLGWRDRNKGKPGNVDGPNDAKPSNEGQNTEIPQKDTNDKETNGKDTNEKELNGRDTDDKGTNDIEEQHKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYX5</accession>
    <name>A0A0D2UYX5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G2842002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2UYX5"/>
    <dbReference type="Gramene" id="KJB74271">
        <property type="protein sequence ID" value="KJB74271"/>
        <property type="gene ID" value="B456_011G2842002"/>
    </dbReference>
    <dbReference type="OMA" id="WSAMTKM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065">
        <property type="entry name" value="OS10G0469600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48065:SF11">
        <property type="entry name" value="OS11G0213300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="10">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB74271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="180" mass="19405" checksum="41F8A71C71AEB366" modified="2015-04-29" version="1" fragment="single">MSFLRVLNLLNNSFYNQIPQSIGGLRRLETLYLTNNSVSGEIPSNLSSCSKLTIVRMAGNRLTGEIPAFLGFLSNLKVLSFYNNSLRGSIPPSLGNLSSLEELALTYNALDGIIPETLGRLTNLSIFLAAANAISGTLPVAMFNLSNIRGNKISGQIPISITNASNLDVLQFNDNRLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5H8</accession>
    <name>A0A0D2V5H8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_012G147000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5H8"/>
    <dbReference type="SMR" id="A0A0D2V5H8"/>
    <dbReference type="STRING" id="29730.A0A0D2V5H8"/>
    <dbReference type="Gramene" id="KJB77616">
        <property type="protein sequence ID" value="KJB77616"/>
        <property type="gene ID" value="B456_012G147000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77617">
        <property type="protein sequence ID" value="KJB77617"/>
        <property type="gene ID" value="B456_012G147000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779211"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEADQCK"/>
    <dbReference type="OrthoDB" id="1519200at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB77616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="450" mass="49541" checksum="4A04B06543419980" modified="2015-04-29" version="1">MRECISIHIGQAGIQVGNACWELYCLEHGIQPDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGAYRQLFHPEQLISGKEDAANNFARGHYTIGKEIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTVYPSPQVSTSVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYTNLNRLVSQVISSLTASLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVISAEKAYHEQLSVAEITNSAFEPSSMMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVASIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVQRAVCMISNSTSVAEVFSRIDHKFDLMYAKRAFIHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAESAEGDEGEDDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V6N1</accession>
    <name>A0A0D2V6N1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dirigent protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G145700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V6N1"/>
    <dbReference type="STRING" id="29730.A0A0D2V6N1"/>
    <dbReference type="Gramene" id="KJB77589">
        <property type="protein sequence ID" value="KJB77589"/>
        <property type="gene ID" value="B456_012G145700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778829"/>
    <dbReference type="eggNOG" id="ENOG502RXST">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARTHSWE"/>
    <dbReference type="OrthoDB" id="1864232at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
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    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB77589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="202" mass="22447" checksum="322F8200AF955354" modified="2015-04-29" version="1">MVASVLKTQSFIIFLILFFITIITSFSRLTVAYGYSELFGKYISPSSLGLKREKLSHLHFYLHDVLSGKNITGIRVVDGKPSTNRSSQFMFGDVYVIDDPLTIEPDINSKTVGKAQGTYTVASQGELSLLMVTNFAFTEGKYNGSTLSVLGRNEVLSTAREIPIVGGSGVFRFARGYAQVRTQSINQARAIVEYNVFVFHYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VAK1</accession>
    <name>A0A0D2VAK1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G1450001</name>
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    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_010G1450001"/>
    </dbReference>
    <dbReference type="OMA" id="NECLEYK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001019">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF861">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 14 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB66585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="117" mass="13621" checksum="77C5ED5D93365E9B" modified="2015-04-29" version="1" fragment="single">MLLAKLQHRNLVRLLGLSFAQKERILIYEFLPNSSLDNFIFDPVKCSLLNWEKRYKIIEGIAKGLLYLHEDSQYRIIHRGLKPANILLDEEMNPKISDFGMAKLFTVDQTRADTSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCB2</accession>
    <name>A0A0D2VCB2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G113900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VCB2"/>
    <dbReference type="Gramene" id="KJB80751">
        <property type="protein sequence ID" value="KJB80751"/>
        <property type="gene ID" value="B456_013G113900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254139" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11109" checksum="919A04AADB1A8229" modified="2015-04-29" version="1">MLYFAKILCCFAIRNMGISCALVHHMLLHCGTAVWSKQASRPNQCLVCDANKCMGPPDNAVDCDMIDVQNQSGTFSAKFYKKFMQLLVVFLLLFSIEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VE38</accession>
    <name>A0A0D2VE38_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G148800</name>
        <name evidence="11" type="ORF">Gorai_003041</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
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        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0598968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VHD4"/>
    <dbReference type="STRING" id="29730.A0A0D2VHD4"/>
    <dbReference type="Gramene" id="KJB69485">
        <property type="protein sequence ID" value="KJB69485"/>
        <property type="gene ID" value="B456_011G025900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776978"/>
    <dbReference type="eggNOG" id="KOG0323">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYQSTLC"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009755">
        <property type="term" value="P:hormone-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000035">
        <property type="entry name" value="RNA polymerase II C-terminal domain phosphatase-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000035">
        <property type="entry name" value="RNA polymerase II C-terminal domain phosphatase-like 2"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
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    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="RNA POLYMERASE II C-TERMINAL DOMAIN PHOSPHATASE-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FCP1 homology" evidence="18">
        <location>
            <begin position="151"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="17">
        <location>
            <begin position="719"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="17">
        <location>
            <begin position="855"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="540"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="676"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="787"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="927"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="927"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="944"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023163"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50137"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB69485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBA0598968.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="973" mass="109067" checksum="11CCF17E8DB1EC01" modified="2015-04-29" version="1">MSMYKSVVCRGDEVLGEVEIYPQQQQLREEEEEYGGKITVMEEEMKEIRIGYLTQGSERCPPLAVLHTITSTGICFKMESSKDNNYSSSFQDTPPLHLLHSECIRDNKTAVMPMGDCELHLVAMYSRNSDRPCFWGFNVARGLYDSCLVMLNLRCLGIVFDLDETLVVANTMRSFEDRIEALQRKMNTEVDTQRAAGMMAEIKRYQDDKAILKQYAENDQVVENGKVIKVQSEIVQPLSDNHQPIIRPLIRLQEKNIILTRINPQIRDTSVLVRLRPAWEDLRSYLTARGRKRFEVYVCTMAERDYALEMWRLLDPESNLINSKELLDRIVCVKSGLRKSLFNVFQDGICHPKMALVIDDRLKVWDEKDQPRVHVVPAFAPYFAPQAEANNTIPVLCVARNVACNVRGGFFREFDEGLLQKIPEISYEDDIKDIPSPPDVGNYLVSEDDTSASTANKDPPIFDGMADAEVERRLKEAISAASTVSSASINLDPRLASSLQFTMPSSSSVPLLAVQSSMASYPNMQFPQAAQVIKPVAPVVSPEPSLQSSPAREEGEVPESELDPDTRRRLLILQHGQDTRDHTPPEPAFPPARPAMQVPVSRAQSRGSWFSSDEEMSPRQLNRAVPKEFPLDSEQMHMEKHRGPPFFPKVESPIPSERLLRENQRLPKEALHRDDRLGLNHTPSSYHSFPGEEMPLGRSSSSHKDLDFESGRTIPSGETPAGVLQDIAMKCGAKVEFRPALVASMDLQFSIEAWFAGEKVGEGTGRTRREAQRQAAEDSIKSLANTYLSRIKPDTGSTQGDLSRSANTNENGFPGNLNLYGNQQSPKEESMPFSNAPEPSRLLDPRLEGSRRSMGSVTALKELCMMEGLGVVFQAQPPASNTLQKDEVYAEVEVDGQVLGKGTGFTWEEAKMQAAEKALGSLRSMLGQFTQKRQGSPRSLQDMPSKRLKPEFPRVLHRMPSSGRYHKNAPPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W185</accession>
    <name>A0A0D2W185_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G036800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycine-rich RNA-binding protein GRP1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
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    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
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    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
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    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
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    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
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    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
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                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
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    </reference>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Brubaker C.L."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the plastidial phosphorylated pathway of serine biosynthesis (PPSB). Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine.</text>
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    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
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        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
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        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0579279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
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    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="61"/>
            <end position="408"/>
        </location>
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            <dbReference type="EMBL" id="KJB10382.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="17">
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            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="420" mass="46398" checksum="2CEC7EDCEE07D565" modified="2015-04-29" version="1">MAATSLNAPNAPLLQKTHQTHVFLKPISTIPCQTSAKRFSISCSATTQDRLSVQSQSQDRVFNFAAGPATLPENVLLKAQSELYNWHGSGMSVMEMSHRGKDFRSIIEKAETHLRSLLNIPENYAVLFLQGGATTQFAAVPLNLCAPGDSVDYLVTGSWGDKAFKEAKKYCNPKVIWSGKSENYVRVPSFDGLELNPNGKYLHICANETIYGVEFKDYPVPRNPNGVLVADMSSNFCSKPVDVTKFGLIYAGAQKNVGPSGVCIVIVRKDLLGNAQEITPVMLDYKIHADNNSLYNTPPCYGIYMCGLVFEDLLKQGGLEEVEKKNQKKAGILYNAIDESKGFYRCPVEKSVRSLMNVPFTLEKSELEAEFLKEAEKEKMVQLKGHRSVGGMRASIYNAMPLAGVEKLVAFMKDFQAKHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MB80</accession>
    <name>A0A0D2MB80_GOSRA</name>
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        <recommendedName>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G148300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB14907"/>
        <property type="gene ID" value="B456_002G148300"/>
    </dbReference>
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    <dbReference type="OMA" id="ERMSEYI"/>
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        <property type="component" value="Chromosome 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33649">
        <property type="entry name" value="PAR1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PAR1 PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
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    <feature type="chain" id="PRO_5002246833" description="PAR1 protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB14907.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="24220" checksum="D1864C735EAF76B3" modified="2015-04-29" version="1">MPCFKIPLFLFLSSLFLHASLAEIICEDLPNDVCAFAIASSGKRCLLETALEKNEKEEYQCRTSEVMVERMAEYIENDDCVRACGVDRNSIGISSDSLLEPQFTSKLCAPACCHNCPNIVDLFFNLAAGEGVFLPDLCEAQRINPRRSMVELMSSSGAALGPISSEASALAPSPTPPITSEVPDSNEALASILSPSSISSEASTPGPGLAPISSEASSSTSSPGPTPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MCW0</accession>
    <name>A0A0D2MCW0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G187300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MCW0"/>
    <dbReference type="Gramene" id="KJB15632">
        <property type="protein sequence ID" value="KJB15632"/>
        <property type="gene ID" value="B456_002G187300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB15632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="86" mass="10107" checksum="C0F17A1ACB40D961" modified="2015-04-29" version="1">MEQRSIEFASKFPDQILDKLQSQRFLGSLNYVIYFYPGLSKLSDPNASKIVETDAFEIRYGGILKQIFARWQTILSIFDFDIEYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MVD2</accession>
    <name>A0A0D2MVD2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G079300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MVD2"/>
    <dbReference type="STRING" id="29730.A0A0D2MVD2"/>
    <dbReference type="Gramene" id="KJB23066">
        <property type="protein sequence ID" value="KJB23066"/>
        <property type="gene ID" value="B456_004G079300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB23067">
        <property type="protein sequence ID" value="KJB23067"/>
        <property type="gene ID" value="B456_004G079300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790718"/>
    <dbReference type="eggNOG" id="KOG2808">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRTEYAW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.940.10:FF:000004">
        <property type="entry name" value="Pre-mRNA-splicing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.110:FF:000005">
        <property type="entry name" value="Pre-mRNA-splicing factor 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="9">
        <location>
            <begin position="101"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB23067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="420" mass="47448" checksum="1A68C8D4390CEB2F" modified="2015-04-29" version="1">MDLLKEELLKKRQSLAQNTGGKRVFKRSEIEQKQIQKLREQEKRELEAKCHRQSTASPSNVSDTSAKPNPSASSTASTIATSTAGSSKSLTDEQNIDNLDLPRQEVIRRLRFLKQPITLFGEDDAARLERLKYVLKAGLFEVDSDMTDGQTNDFLRDIAELRKRQKTGILSDRKRKDREEGEGGGQDREEEGGGGGGELSGDGDGGSSGVDMDKDLKRMKANFDELCDEDKILVFFKRLLNEWKQELDDMGEAEKRTAKGKSMVATFKQCARYLNPLFKFCRKKVLPDDIRQALLVVVECCMKRDYLAAMDHYIKMAIGNAPWPIGVTMVGIHERSAREKIYTNSVAHIMNDETTRKYLQSVKRLMTFCQRRYPTLPSKAVEFNSLANGSDLQSLLAEERDSRVSSSDDKLRLMPTPTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N4X0</accession>
    <name>A0A0D2N4X0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PGG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G289100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N4X0"/>
    <dbReference type="STRING" id="29730.A0A0D2N4X0"/>
    <dbReference type="Gramene" id="KJB27212">
        <property type="protein sequence ID" value="KJB27212"/>
        <property type="gene ID" value="B456_004G289100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB27212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14803" checksum="59079E3D66EFD9F1" modified="2015-04-29" version="1">MAREIIENVERKGLSMSGEDDDKIKRIKKKLDTLELILVMLIRARNGLSENMINATLVTVALVITAIYQSSLSPPRGVWQVDNNSIPTTTSNVTTTALQIFDDNYNNSRFKHLLGQESRKTEGSNNQHSNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NBR9</accession>
    <name>A0A0D2NBR9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G197200</name>
        <name evidence="7" type="ORF">Gorai_021532</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NBR9"/>
    <dbReference type="SMR" id="A0A0D2NBR9"/>
    <dbReference type="STRING" id="29730.A0A0D2NBR9"/>
    <dbReference type="Gramene" id="KJB10357">
        <property type="protein sequence ID" value="KJB10357"/>
        <property type="gene ID" value="B456_001G197200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10361">
        <property type="protein sequence ID" value="KJB10361"/>
        <property type="gene ID" value="B456_001G197200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10362">
        <property type="protein sequence ID" value="KJB10362"/>
        <property type="gene ID" value="B456_001G197200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10363">
        <property type="protein sequence ID" value="KJB10363"/>
        <property type="gene ID" value="B456_001G197200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800364"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NQASECE"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="8"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0579271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="263" mass="29527" checksum="59E56269682545E8" modified="2015-04-29" version="1">MSSTGSTREENVYMAKLAEQAERYEEMVEFMEKVVKAVNVEELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEESKGNGDHVAIIKEYRGKIEAELSKICDGILSLLESHLIPSASTAESKVFYLKMKGDYHRYLAEFKTGVERKEAAESTLLAYKSAQDIAIVELAPTHPIRLGLALNFSVFYYEILNSPDRACNLAKQAFDDAISELDTLGEESYKDSTLIMQLLRDNLTLWTSDITDEAGDEIKEAPLKPESGEGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NCR5</accession>
    <name>A0A0D2NCR5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_001G223400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NCR5"/>
    <dbReference type="STRING" id="29730.A0A0D2NCR5"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSLVNCN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF2">
        <property type="entry name" value="RECEPTOR LIKE PROTEIN 30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="907"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="2"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="14">
        <location>
            <begin position="189"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB10768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="955" mass="106152" checksum="6625B8587D39D564" modified="2015-04-29" version="1" fragment="single">LDSERSALLRLKDGFILNRSASYDTLAYPKVSSWKLEGQVGGDCCSWDGIECDDNTGHVIGLDLSSSFLYGSINSNNSLFQLHHLRRLNLSDNNFNRSEIPSAIGNLTRLSRLDLSWSGFTGQIPYEVLLLSNLVILDLSRNRLELRNPSLKSLSERLLNLKHLDLYMVNVSSTIPQSLANLSALTYLSLDACELHGSFPIEVFQLHHLRRLSLCDNDFNGSEIPSAIANLTRLSRLDLSSSGFTGQIPYEVLQLSNLILDLDMVNVSSTIPQSLANLSALTYLSLEGCELHGTFPTSLANLTQLTYLSLAGNEFSPATLPWLTQLTKLTALNLDSTNSYGEVLSYLKNLTKLTYLTLTRNQFSERIPSWFGNLTGLNTLALGSNEFWGSIPKSIFTLKNLVDLDLYGNHLSGTYKLESFLNLKNLKTLQLSSNQFSLLSTTVINVTVPKFTLLTLASCNLSKFPSFLSSQDKLELLDLGGNKIHGCIPKWIWGLSGQTLQVLDLSENFLTGFDEPTVVPSWTILRKLDLSYNMLQGSLPNLPASIYQYFVSNNLLKGEISSGICNLTSITVLDLSNNSFSGMLPPCLGNLSESLSVLNLQNNNFSGPIPRACEKGNTLRMIDLSQNQLNGRIPRSLVNCNMLELLNLGNNQIEDTFPSWLGRLQELKILILRHNGFHGAIGEPKSNEFPKLQILDLSFNKLTGCLPSRHFQIWKAMKVVDVGNLRYLKADVSFEGRETNWTIDFSYSMTMTKAGVELKYEKIQDFLVAIDLSSNKFDGCIPEDIQMVKALQFLNLSNNFLSGPIPSSLANLSNLQALDLSRNKLSGEIPQELVQLTFLGFFNVSHNQLTGPIPQGKQFGTFENNSFEGNLGLCGNPLSKKCYPKGLSPPPPSLSKKDDGEDSWLQLGWKAIMLGYGSGVVNGLVLGYLFNPMKHKLFVKYFGRKMQNRRRGRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NHI3</accession>
    <name>A0A0D2NHI3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">cinnamyl-alcohol dehydrogenase</fullName>
            <ecNumber evidence="5">1.1.1.195</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_005G234800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(E)-cinnamyl alcohol + NADP(+) = (E)-cinnamaldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10392"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16731"/>
            <dbReference type="ChEBI" id="CHEBI:33227"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.195"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:10394"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Aromatic compound metabolism; phenylpropanoid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.195" evidence="5"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NHI3"/>
    <dbReference type="STRING" id="29730.A0A0D2NHI3"/>
    <dbReference type="Gramene" id="KJB32312">
        <property type="protein sequence ID" value="KJB32312"/>
        <property type="gene ID" value="B456_005G234800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045551">
        <property type="term" value="F:cinnamyl-alcohol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009809">
        <property type="term" value="P:lignin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000004">
        <property type="entry name" value="probable cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000100">
        <property type="entry name" value="Putative cinnamyl alcohol dehydrogenase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0438">Lignin biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="20"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB32312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="381" mass="41317" checksum="592A9917FB1A1FC8" modified="2015-04-29" version="1">MGSLENERKTTGWAARDPSGILSPYTYSLRNTGSEDVFIKVICCGICHTDIHQAKNDLGMSNYPMVPGHEVVGEVVEVGSGVNKFTAGDIVGVGYVVGCCKNCSPCNTDREQYCAKKIWTFNDVYTDGKPTQGGFSGSMLVDQKFVVKIPDGLAPEQAAPLLCAGVTVYSPLNHFGLKESGLRGAILGLGGVGHMGVKMAKAMGHHVTVISSTDKKKTEALDHLGADEYLVSSDTEAMQKAAESLDYIIDTVPAFHPLEPCLSLLRIDGKLILTGVTNTPLQFLTPSVMLGESNLKFFLGFHFSMSLKLCVETGRKSIAGTLVGSMKEQEEMLAFCKEKNLTSMVEVVKMDYINTAMERLEKNDVRYRFVVDVAGSKIDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NNT6</accession>
    <name>A0A0D2NNT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S2, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G086500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NNT6"/>
    <dbReference type="STRING" id="29730.A0A0D2NNT6"/>
    <dbReference type="Gramene" id="KJB34827">
        <property type="protein sequence ID" value="KJB34827"/>
        <property type="gene ID" value="B456_006G086500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQARRIY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB34827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8072" checksum="7F598669B4454994" modified="2015-04-29" version="1">MGMKFTRLGQTLAGLCQARRIYDSSTICLIDTNSDLGLADISIPANDDAIASIQLILNKLVVAICEGRSSYIQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P0X4</accession>
    <name>A0A0D2P0X4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G133700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P0X4"/>
    <dbReference type="STRING" id="29730.A0A0D2P0X4"/>
    <dbReference type="Gramene" id="KJB20113">
        <property type="protein sequence ID" value="KJB20113"/>
        <property type="gene ID" value="B456_003G133700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0101">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMTKGNK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000012">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB20113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="289" mass="32123" checksum="550D29B2AADDBBA7" modified="2015-04-29" version="1">MDKSIVHDVVLVGGSTRIPKVQQLLQDFFNEKELCKSINPDEVFAYVTVVQAAILSGEGNENVQDLLFLDVTLISLGLEIAAIQKKKEQVFSTYFDNQPGVLIQVYEGERTRTRDNNLLGKFELSGIPPAHRGVPQINVCFDIDANGILNISTEDKTTGQKNKITITNDKGKLSKEEIEKMVQEMKKYKSEHEEHEKKVEAKIAHENYTYNMRNTIKDDKTSSKLSAADKKKIEDAVEEAIQWLDGNQLAEELEDICNPIITKMYQGASGDMGGGSIDEDAPATGRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2R9</accession>
    <name>A0A0D2P2R9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_003G168600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P2R9"/>
    <dbReference type="STRING" id="29730.A0A0D2P2R9"/>
    <dbReference type="Gramene" id="KJB20848">
        <property type="protein sequence ID" value="KJB20848"/>
        <property type="gene ID" value="B456_003G168600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789223"/>
    <dbReference type="eggNOG" id="ENOG502S7AI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQPATTC"/>
    <dbReference type="OrthoDB" id="690947at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248519" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB20848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="141" mass="14884" checksum="FE50DBE2EBB4099D" modified="2015-04-29" version="1">MAQKMMMMAVLVILGTMMATFTVAQETCAQSLVPCAPYLNNATAQPQDDCCNPIKQAVETQLTCLCNLFNDPTLLSSFNVTVSEALRIARECGVTTDLSACNNATSPTSAPPPPGESGGADRIVLTGITTLFLFLASIALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PBA0</accession>
    <name>A0A0D2PBA0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DCD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G131900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PBA0"/>
    <dbReference type="STRING" id="29730.A0A0D2PBA0"/>
    <dbReference type="Gramene" id="KJB24183">
        <property type="protein sequence ID" value="KJB24183"/>
        <property type="gene ID" value="B456_004G131900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791332"/>
    <dbReference type="eggNOG" id="ENOG502QSUM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFNDGWN"/>
    <dbReference type="OrthoDB" id="1908866at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013989">
        <property type="entry name" value="Dev_and_cell_death_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044832">
        <property type="entry name" value="NRP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46034:SF37">
        <property type="entry name" value="DCD DOMAIN-CONTAINING PROTEIN NRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10539">
        <property type="entry name" value="Dev_Cell_Death"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00767">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51222">
        <property type="entry name" value="DCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCD" evidence="2">
        <location>
            <begin position="178"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB24183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="313" mass="35109" checksum="88CA74662B15DB6D" modified="2015-04-29" version="1">MENNQQSFWHFSDQLRIQNSNLANLSLNDSIWSNSYVSKRPDERRNFDIRVGGEVNSVNNLKPKVSDFNSFNNDGWKIGATTNNIGFGPIAPKNTGINGGFNKGVYSKPANNNNFNVSLKGNKNRGEDDHGSKSGKKNSNKKKNNNSDNNNNETKDGGSAADKRFKTLPPSEALPRNETVGGYIFVCNNDTMQENLKRQLFGLPPRYRDSVRAITPGLPLFLYNYSTHQLHGIFEAASFGGTNIDPTAWEDKKCPGESRFPAQVRVLTRKICEPLEEDSFRPILHHYDGPKFRLELNVPEALSLLDIFAEQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PC46</accession>
    <name>A0A0D2PC46_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G196600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PC46"/>
    <dbReference type="Gramene" id="KJB43372">
        <property type="protein sequence ID" value="KJB43372"/>
        <property type="gene ID" value="B456_007G196600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801522"/>
    <dbReference type="eggNOG" id="KOG0014">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CMIIFEP"/>
    <dbReference type="OrthoDB" id="601557at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF502">
        <property type="entry name" value="AGAMOUS-LIKE MADS-BOX PROTEIN AGL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB43372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="406" mass="46278" checksum="266AF75E9757480B" modified="2015-04-29" version="1">MARRKLKMKLIEKEKARAATLKKRLQSLKKKAHEFSTLCDVEVCMIIFEPELKDSPSRVEVWPSDPVQVETIIGRYNTMATSGSQKKTFSISDFFNMCRRQARDEVAQVCKANFKAKFPTWDDRIDNFSPEHIASCLTKLDSNIEVVKRKIMLMKGDDEQKLLRSELRTLGGFGARSTLSSSDNYIPAAALHLWNRSLLDNNIQTHTPLEIVNHFDLIQDIPRKNSEFGVIRDQPPLPARPLDMQLPSFSPADEALVKLSLSLNPIEKSLRMSMMNDLGFGVRSGIASSSKNSFPNNAMYNPPPSYSICHDPRFGMPSNDVMFDSASMPVLHDPRSNGVQNNVMLKEPKSALETCFYAPSMRPEVATYNQQQLMMPHVFSQMPPPEFTDFYHDINQHEMINKKQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PK38</accession>
    <name>A0A0D2PK38_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G366400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="980" mass="109933" checksum="6B9BDA5A882F1C38" modified="2015-04-29" version="1">MRTKRKRACKKSPARKSAAVARNGKATNQSEKAVNQNKEAFLTSINKINKEDSVSADSNDLEVTDKCDSDPDDAKRNSSSSSSSSDSDESFSAEDSSSGDSQSIDRRSRKSTKGHGNGKQKASKLPKKGRKDDVKSSKLLRSSGKRQDEFKMPQQDPRYNKKELEAALEVIKKIMKMDEAQPFNVPVDPVASGKPDYYAVIDTPMDFGMICSNLESSMKYLNSEDVFNDVQYIWENCCKCNKKGEYIVYLMKRVKKKFMKYWTAAGLSIKQSRQINVGTSYKPSTTDYATRHSGLEPFYQVSSAVGGASQMQQDQLGFSQPYGYMPPFSYSQPHQLPQPTPSTSWPQFSPLPPVSYHQHCQSQHPQPSTNQSQFSQLQACTGCNNAGYSHLQPPKEIAPKHKKHEPSSKHKKNAAMAPTASICGGAPSDSHAQQPQLSNKQPYFLRQRQSISPLQPSQLHAAADGDIAPKLKKHASMSKHRKNSSMNPASSIHGGPPGHSQTQLQAVVNGVKLHLPPQADYTRSSGYVPLYPVDPMAVPGQSHPQQSPLSRSESSEPQQLHPKTSHCRPQSSQLQDNLDIEYSHMSLTDSALRGIRCALEYSARPTTNKSNKANQDQLASVNLQPEQTPQSPEHPQRITKKKRGRGPTRCHFLNDLADGERIFVHFNKFGQPVGPESSKLSSFLGTIARNGHKAPLNFVHWRAMPDSYKEEMWEYVQTKFSLDPSGKSWVMQSIATKWRNWKADLKATYYDSLKTDEERLKVRDPRVVPDQWPSLISYWSSDDTKKHCATNRANRLKQRSGHSSGTKSYARILEEERNKRPDGKEPTRAELYILTHTRKNGQPVDETAAELISKIREQEAKKETTSQCSDESNDTLCRVMGEENHNRVRTYRMRSTCTDLFGPISSRDDLVRMASEAKKSADEEVRKMVVKMEAMEEKYARMENHIARMTSSMEKFLKKVGGSSNTLGLEQAAEPEEDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PPC1</accession>
    <name>A0A0D2PPC1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G097800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with F-actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PPC1"/>
    <dbReference type="STRING" id="29730.A0A0D2PPC1"/>
    <dbReference type="Gramene" id="KJB08688">
        <property type="protein sequence ID" value="KJB08688"/>
        <property type="gene ID" value="B456_001G097800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08689">
        <property type="protein sequence ID" value="KJB08689"/>
        <property type="gene ID" value="B456_001G097800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790092"/>
    <dbReference type="eggNOG" id="KOG0046">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWKQATK"/>
    <dbReference type="OrthoDB" id="431378at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032432">
        <property type="term" value="C:actin filament bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051639">
        <property type="term" value="P:actin filament network formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21293">
        <property type="entry name" value="CH_AtFIM_like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21296">
        <property type="entry name" value="CH_AtFIM_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21299">
        <property type="entry name" value="CH_AtFIM_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000045">
        <property type="entry name" value="Fimbrin-1 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000041">
        <property type="entry name" value="Fimbrin-2 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000031">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000034">
        <property type="entry name" value="Fimbrin-2 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039959">
        <property type="entry name" value="Fimbrin/Plastin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961:SF79">
        <property type="entry name" value="FIMBRIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19961">
        <property type="entry name" value="FIMBRIN/PLASTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="120"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="265"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="390"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="8">
        <location>
            <begin position="511"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="623"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB08689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="655" mass="73301" checksum="29CDA439DF241696" modified="2015-04-29" version="1">MSSYQGVIVSDPWLQSQFTQVELRTLKSKFINVRTQHGRVTLGDLPPVFSKLKAFTEMFNEDEIKTVLGESNSGMGEEIDFEGFLRAYLNLQTHAIEKSGGTKSSFLKATTTTFHHAINESEKASYVAHINNYLAEDKFLKDFLPIDPATDALFDLAKNGVLLCKLINVAVPGTIDERAINTKKVLNPWERNENHTLCLNSAKAIGCTVVNIGTQDLAEGRPHLILGLISQIIKIQVLADLNLKKTPQLVELVDDSQDVEELLSLAPEKVLLKWMNFHLKKVGYEKQVTNFSTDLKDGEAYAYLLNALAPEHSTPSTLDTSDPTERANMVLQQAEKLECKRFLTPKDIVEGSPNLNLAFVAQIFHNRNGLSTESKNMSYAEMMTDDVETSREERCFRLWINSLGISTYVNNLFEDVRNGWVMLEVLDKLFPGTVNWKQANKPPIKMPFKKVENCNQVINIGKDLNFSLVNVAGNDVVAGNKKLIVAFLWQLMRFSMLQLLKNLRSFSHGKEITDADILNWANNKVKKSGRTTQMESFKDKSLSNGVFFLELLTAVEPRVVDWNLVTKGETDEDKKSNATYIISVARKIGCSIFLLPEDVIEVNQKMILTLTASIMYFCLQQQGEGPDDSDLASEVSRLSVDGSVSDAAPSPQAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PR27</accession>
    <name>A0A0D2PR27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gag-pol polyprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G106200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PR27"/>
    <dbReference type="Gramene" id="KJB29538">
        <property type="protein sequence ID" value="KJB29538"/>
        <property type="gene ID" value="B456_005G106200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12725" checksum="7D958DB6D95D014C" modified="2015-04-29" version="1" fragment="single">MDTENGRTIKPKTLWATIKERFASADSKALYVISYGVNMQECKRTAKCIVQKEYSNTKLARKVLRSLSKRFSIKVTTIEEAKNLESLEINELIGSLQTFNMNLEGAKCTKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSU4</accession>
    <name>A0A0D2PSU4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable purine permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G111600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine permeases (TC 2.A.7.14) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2PSU4"/>
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        <property type="gene ID" value="B456_008G111600"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QRUH">
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    <dbReference type="OrthoDB" id="1907510at2759"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030182">
        <property type="entry name" value="PUP_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376">
        <property type="entry name" value="OS09G0467300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31376:SF2">
        <property type="entry name" value="PURINE PERMEASE 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16913">
        <property type="entry name" value="PUNUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="51"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
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            <end position="341"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_001G215200"/>
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        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rcd1"/>
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    <evidence type="ECO:0000313" key="2">
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32331" checksum="887377572CD489BE" modified="2015-04-29" version="1">MVSGAAAPVTSNPSARVIYLIRGLASEETREQSLDVLCKNRLTYDNLAVLLWKSFGTMSVLLQAAYRALSSDGLTEKALTQVCNAIALFQVTSLLSHQIQLLLAALIEINISFVATMPVYLYPFLNTMSNERSYECLRITSLGVIGCLRCMEVGKTLSRTVSTFIIYRILLSEKGLKYCFVLAERYLSVSQCLGKLVENLSEDDAENLPCLLRNIIGCYLRLSENERTRPQLSSYVPWKLLDGKYANIVRSDPKALANLRQLVCNLRTSKSCATHCTDEPPTSSNSPGPSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PV89</accession>
    <name>A0A0D2PV89_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G186800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PV89"/>
    <dbReference type="STRING" id="29730.A0A0D2PV89"/>
    <dbReference type="Gramene" id="KJB31328">
        <property type="protein sequence ID" value="KJB31328"/>
        <property type="gene ID" value="B456_005G186800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1577">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NISRECP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="170" mass="19434" checksum="3E47B0B1CE0377D3" modified="2015-04-29" version="1">MVEANLKFDMVPFLYKWNESDLCLHYSHSIAIFFCKVEFNPLWNQKKLREYCKANGVLLIGYSPLGASGTLWGSSRVLENEVLKEIAEAKGKTVAQICLKWAFEEGVGVIVKSFNVERMKQNLEILDWSLSEEERKRIGDLPQSRGCTGEPFVSENGTFKTIKDFWDGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q6A7</accession>
    <name>A0A0D2Q6A7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FGGY carbohydrate kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G006500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q6A7"/>
    <dbReference type="STRING" id="29730.A0A0D2Q6A7"/>
    <dbReference type="Gramene" id="KJB53807">
        <property type="protein sequence ID" value="KJB53807"/>
        <property type="gene ID" value="B456_009G006500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769833"/>
    <dbReference type="eggNOG" id="KOG2517">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKAMWHE"/>
    <dbReference type="OrthoDB" id="203824at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019150">
        <property type="term" value="F:D-ribulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019321">
        <property type="term" value="P:pentose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07782">
        <property type="entry name" value="ASKHA_NBD_FGGY_D-RBK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000101">
        <property type="entry name" value="FGGY carbohydrate kinase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006003">
        <property type="entry name" value="FGGY_RbtK-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01315">
        <property type="entry name" value="5C_CHO_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435:SF4">
        <property type="entry name" value="FGGY CARBOHYDRATE KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43435">
        <property type="entry name" value="RIBULOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="6">
        <location>
            <begin position="75"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="7">
        <location>
            <begin position="366"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00074355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB53807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="634" mass="68720" checksum="05D7AFD707D0266C" modified="2015-04-29" version="1">MNMKGKEMLGKGRTRSDTTPLLGKHKQQHQQPHPKNRFHSSPSACSHSISSPLFLEMAAAISSASSSPTSHCNVFLGVDVGTGSARAGLFDEEGKLLGSASSPIQIWKEGDCIEQSSTDIWHAVCSAVKAACSLAKIDGEQVKGIGFAATCSLVAVDADGSPVTVSWSGDSRRNIIVWMDHRAVKQAEKINSCNSPVLQYCGGSVSPEMQPPKLLWVKENLQESWSMVFRWMDLSDWLSYRATGDDTRSLCTTVCKWTYLGHAHMQHINEKDSRDMEACGWDDDFWEEIGLGDLVEGHHAKIGRSVAFPGHALGSGITPTAAKELGLVAGTPVGTSLIDAHAGGVGVMESLPEKENDNEAICHRMVLVCGTSTCHMAVSRDKLFIPGVWGPFWSAMIPEYWLTEGGQSATGALLDYIIESHVASPRLANHAASQKTSLFQLLNNILESMMRELQCPFIAALTEDTHVLPDFHGNRSPIADPKAKGVVFGLTLDPSEQQLARLYLAAVQAIAYGTRHIVEHCNANGHKIDTLLACGGLSKNALFIQEHADIIGCPIILPRESESVLLGAAILGAVAAKKYTCLSEAMKALNAAGQVIHPSTDSRVKKYHDSKYRIFRELYQQQLSQRSIMAQALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q797</accession>
    <name>A0A0D2Q797_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G158600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q797"/>
    <dbReference type="STRING" id="29730.A0A0D2Q797"/>
    <dbReference type="Gramene" id="KJB15069">
        <property type="protein sequence ID" value="KJB15069"/>
        <property type="gene ID" value="B456_002G158600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS8H">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000270">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF51">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="99"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="371" mass="42141" checksum="4424A5B983116305" modified="2015-04-29" version="1">MVSSCFIDYVLSFAIYFTWICLNYTQNIAGIFTKTLLVLFVGALAWAYQAIQPPPPKTCGSPDGPPITASRIKLRDGRHLAYKEHGVPLGAAKYKIVKVHGFDSCRLDAVPLSPELVERLGIYFVSFDRPGYGESDPNPKRTVKSMALDIEELADQLRLGSKFYVIGISMGGQVVWSCLKYIPHRLAGATLVAPAVNYWWSGFPTNLSNQAYQQMLPQDQWVLRVSHYAPWLTYWWNTQKWFPSSSVIANSIDIFSSEDRKLLMKILSTRNHAAQVRQQGEYESLHRDLIVGFGAWEFSPLELDNPFPNNEGSVHVWHGDEDRFVPVMLQRYIAEQLPWIRYHELPGAGHLFMVADGMWDNIVKTLLVGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8T7</accession>
    <name>A0A0D2Q8T7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7806 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G125800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8T7"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8T7"/>
    <dbReference type="Gramene" id="KJB35733">
        <property type="protein sequence ID" value="KJB35733"/>
        <property type="gene ID" value="B456_006G125800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPWA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENASIPH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056708">
        <property type="entry name" value="DUF7806"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35489">
        <property type="entry name" value="TITAN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35489:SF2">
        <property type="entry name" value="TITAN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25091">
        <property type="entry name" value="DUF7806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7806" evidence="3">
        <location>
            <begin position="252"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="348" mass="39407" checksum="281635376D0EE65E" modified="2015-04-29" version="1" fragment="single">KTPSLKRFFFTLQQVKCSSRTTESLVSGFLKSIFPRFLDYQTGMESLYAKLYDKYDKLKKRKLSEMDDIHRDQEEKFLNYVRAAEELIQHLKSENDKLNAEVNELRSEVASIMSSKDKQCVEYQKLLIEESQKYKALSDEVTRLQNRHEEGRVKGGRRDIIPTVSPGSAQVAPQSVSGNSTRMMTRKRRRNSAAETEDSIVSPGSANRKVATLSAFTEELPEKALSSEVLAHAQLPECCKGHISANATDCGTCLFQALIECLVGMKISTVNQTEGLCILALHQSSGYSFSLTWINKTSGEEAELVYRVLSLGTFERVAPEWMRDVIMFSTNMCPIFFERLARVIKLHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEF8</accession>
    <name>A0A0D2QEF8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G228700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEF8"/>
    <dbReference type="Gramene" id="KJB37643">
        <property type="protein sequence ID" value="KJB37643"/>
        <property type="gene ID" value="B456_006G228700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMGHRAV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051555">
        <property type="term" value="P:flavonol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF5">
        <property type="entry name" value="FLAVONOL 7-O-RHAMNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB37643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="325" mass="36353" checksum="DDC32E689496FF5B" modified="2015-04-29" version="1">MDFIHQLLLRGLKVTSKNLHFLNPILSFHSSSNNGQTLVLPFSSHPSIPFGVENLQDVPISFVPYFVEAMAQLYDLLFQWFQTNQSPPVAISFRGYPCPFNINFAARSLLPSLRSWGHHFQYVFGEDSDKMEIIKEEFTNHDRIWAVGPLLPIKATNNERGAPSSIPRDQVIEWLDSCNRDNSRRFHFIWGIEGDSQNLLPLGFEERLAGKGLMIKGWVPQQAIMGHRAVGSYLTHCGWNSAVEGLLGGALLLAWPMQVDHFDNSNLLIDELGVAIRASEGLITVPDSNKLAQVLSEPVSADRPERVRAMKLRQVGLDAIPKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMQ1</accession>
    <name>A0A0D2QMQ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G180500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB21049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QMQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2QMQ1"/>
    <dbReference type="Gramene" id="KJB21049">
        <property type="protein sequence ID" value="KJB21049"/>
        <property type="gene ID" value="B456_003G180500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789336"/>
    <dbReference type="eggNOG" id="KOG3249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHEVHAN"/>
    <dbReference type="OrthoDB" id="71310at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="19"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB21049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="224" mass="25364" checksum="01E063C7C85B7D62" modified="2015-04-29" version="1">MEMEEIVEEETSGKHENMVEITVKTIGPARPSSLHVPSSIKVLDLRKLIARKNHLPVENLKLILQGKVLHDRADEDDIYVRFNDGDSLIVAVKPKAPVGLDIDDDDEDLKFQLPQSTSQWKKKLYSFLRNRMKLPDIVLMAIFSLGLKAWALIILWFTLAPIAHKLDLGPLYILGTGFCLIFLNLGRRQPGDVSAYSIFNEDFRELPGTLNADAIDRDIRTGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QPV8</accession>
    <name>A0A0D2QPV8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pectinesterase</fullName>
            <ecNumber evidence="3">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_001G130900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QPV8"/>
    <dbReference type="STRING" id="29730.A0A0D2QPV8"/>
    <dbReference type="Gramene" id="KJB09235">
        <property type="protein sequence ID" value="KJB09235"/>
        <property type="gene ID" value="B456_001G130900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSQ4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QREYKCY"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000013">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF77">
        <property type="entry name" value="PECTINESTERASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase catalytic" evidence="9">
        <location>
            <begin position="20"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="298" mass="32736" checksum="E513BA2EA3F64B83" modified="2015-04-29" version="1" fragment="single">MASHGSNAATKALLIKIDPSGKGDYRKIQDAIDAVPSNNKQVVLISVKPGIYEEKIIVPANKPFITISGSNPNDTVITWNDSGNIFESPTFSVLASDFVAQYLTIQNTYGVGAKAVALRVSGDRVAFFGCRILSYQDTLLDDTGRHYYSNCYIEGAVDFICGNAASLFEKCHLHSLSEGDASITAQHRDSPSQNTGFTFLGCKITGVKTALLGRAWGPYSRVIFAFTYMSNVILPQGWDDWGDSSKQREYKCYGPGASTKKRVEWAKELTIEEANPFLTKNMIGGKSWITSTTYRFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSY9</accession>
    <name>A0A0D2QSY9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G149100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYB-CC family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2QSY9"/>
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        <property type="protein sequence ID" value="KJB42348"/>
        <property type="gene ID" value="B456_007G149100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB42349">
        <property type="protein sequence ID" value="KJB42349"/>
        <property type="gene ID" value="B456_007G149100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB42350">
        <property type="protein sequence ID" value="KJB42350"/>
        <property type="gene ID" value="B456_007G149100"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025756">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046955">
        <property type="entry name" value="PHR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499:SF80">
        <property type="entry name" value="HTH MYB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31499">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR PHL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14379">
        <property type="entry name" value="Myb_CC_LHEQLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="478" mass="52542" checksum="846E7B223C6F30D6" modified="2015-04-29" version="1">MEARPALSIQRSGASQLSSLGVSGGLSSSLSIPSTHLEGTYQKLPDIQQVPSERELTTRPQAHATRVPTNNGVVGHIFSSSSGFSSDLHYSSVLPNEKHSRNSPFISQSLADTASLPLSQSSSSLLPQPTIPSCCNKENSGSWCTDPDFLDFPVSTPVQSGQVENIQRSEDFSKQNDWQEWADQLITCDDALTSNWNELLVDNVTNLEPKMACQVAKPCTTMPAQNQQLPSPSVESLRVVNPSSSANNAPAKPRMRWTPELHEAFVEAVNQLGGSERATPKGVLKLMKVDGLTIYHVKSHLQKYRTARYRPESSEGSSEKKLTSMEEISSLDLKTGMGITEALRLQMEVQKRLHEQLEIQRNLQLRIEEQGRYLQMMFEKQKSGLDKLKVSSSNPENPAATSDATKEAPTKSELESSQRDHLDSGTGTVNNAKSMLERSSREMGGEDMATEAGDLEKTKARVSETSPEQAAKRSRIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QTE2</accession>
    <name>A0A0D2QTE2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G203000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QTE2"/>
    <dbReference type="SMR" id="A0A0D2QTE2"/>
    <dbReference type="Gramene" id="KJB10475">
        <property type="protein sequence ID" value="KJB10475"/>
        <property type="gene ID" value="B456_001G203000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771382"/>
    <dbReference type="eggNOG" id="ENOG502S9I7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IATMHER"/>
    <dbReference type="OrthoDB" id="1667576at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38225">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38225:SF4">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="127" mass="14529" checksum="F6071F74BA8ECB04" modified="2015-04-29" version="1">MASSLPSSFAIISPSSNHYSRQPIHVRAQSFRDGGGSSNRVDANLSVLRERIEQVKMKEKLERCCRSYDKWGWNYGAGYNYKVKRDGQLSELFELLSLVGATLGFTCLTGILFLCFFSFFLHLNQWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYY8</accession>
    <name>A0A0D2QYY8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrile-specifier protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_004G166500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYY8"/>
    <dbReference type="STRING" id="29730.A0A0D2QYY8"/>
    <dbReference type="Gramene" id="KJB24894">
        <property type="protein sequence ID" value="KJB24894"/>
        <property type="gene ID" value="B456_004G166500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791706"/>
    <dbReference type="eggNOG" id="KOG0379">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRDNDVH"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080028">
        <property type="term" value="P:nitrile biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000108">
        <property type="entry name" value="Kelch repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000102">
        <property type="entry name" value="Nitrile-specifier protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
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        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
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    </dbReference>
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        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
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    </dbReference>
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        <property type="entry name" value="Kelch motif"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB24894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35185" checksum="2A18D7A12C2BF894" modified="2015-04-29" version="1">MAEVKGKWVKLNQNGTGPGARSSHAITIVGQKAYVFGGEFTPRVPVDNKLYVFDLNNLTWSVADVTGDVPPPRVGVTMATVSETIYVFGGRDSAHKELDELYSFDTCTNKWVLLSNGDSGPAHRSYHSMTADDRHVYVFGGCGVSGRLNDLWAYDVACQKWIKYPTPGDSCKGRGGPGLAVVQGKIWVVYGFSGVEMDDVHCFDPVQGQWSQVETSGEKPTARSVFSTVGIGKCIIIYGGEVDPSDLGHLGAGKFSGEVYSLDADTLVWKKWEDERGLETHPGPRGWCAFSSGVRDGQLGLLVYGGNSPSNDRLDDIFIFTPSVA</sequence>
</entry>
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    <accession>A0A0D2QZ62</accession>
    <name>A0A0D2QZ62_GOSRA</name>
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    <gene>
        <name evidence="1" type="ORF">B456_009G221200</name>
        <name evidence="2" type="ORF">Gorai_012452</name>
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    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZ62"/>
    <dbReference type="STRING" id="29730.A0A0D2QZ62"/>
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        <property type="protein sequence ID" value="KJB63202"/>
        <property type="gene ID" value="B456_009G221200"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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    </dbReference>
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        <property type="entry name" value="UCP031279"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33526">
        <property type="entry name" value="OS07G0123800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33526:SF13">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031279">
        <property type="entry name" value="UCP031279"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB63202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0595586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="162" mass="17977" checksum="5EEC1587E9197FD2" modified="2015-04-29" version="1">MRSKGHSHNKFMRFITVPFKALVKARDLYVRSLTTCASRVSYGHGSGGCSAQYSGLPRSFSSALSATCNDNEDLRELIRAASVTSLGHRKEMEMLLKQQLRVQMGSKALPKSCSVVMGRIDEEKPCEFEENDASAAVVVKKNNNPRSRSYAVRKTTSSFDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2H5</accession>
    <name>A0A0D2R2H5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G108400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2R2H5"/>
    <dbReference type="Gramene" id="KJB23651">
        <property type="protein sequence ID" value="KJB23651"/>
        <property type="gene ID" value="B456_004G108400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791039"/>
    <dbReference type="eggNOG" id="ENOG502QV8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QVWRGIE"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF149">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="716"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB23651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="844" mass="94459" checksum="D2A3B44839EB2196" modified="2015-04-29" version="1">MVRGKLILICQHGGEFETKDDGSMLYAGGEAHALDISPETGFDDLKYKLAEKCNLELKSLAIKYFLPGNRRTLITLSNEKDLKRMCDFHKDSVTADVFLTGKAGFVPANHGMPAKRKKKATAARPATSKVAPSAGGLKDVTISIATPSDSVAGVNAALRSPSRAAKRTAGRNIVDGLFEVSVADATDTDTIDMSASPADTVKKRRRTASWKRAANGLTIVTVDDNLEETEKTPPRKKVARKFNPIVVANNGDHQLGPVDGSVEKQVESWKNGITEGQDFRSVAEFRDALQKYAIAHRFGYKLRKNDTNRANAVCAVEGCPWRIHASWVPSASVFRVKMLHEPHTCGGESWKIATPAKNWLVNVIKDRLRDSPHHKPKEIATGLLRDFGLELNYAQVWRGIEDARQQLQGSYKDAYNQLPWYCEKIEKTNPGSFTKLVIGDDKRFQRLFLSFNALIRGFQSGCRPLLFLEAIPLKSKYHEILLTATALDGDDGIFPVAFAVVDDENEDSWHWFLEQLRSAVSTSRSLTFVSDRDKGLMKHVLEIFENAHHGYSIYYLMDSFIQNLKGPFFGEGRASLPGCFLAAAKAVRPGGFRMYTEQIKRVSSSAYDWIMQNEPEYWANAFFKGEHFNHITLNIAEAYANWIEEARDLPIIPKVEVIRCKIMELMELRRTESSNWTMKLTPSKQEKLQEECVKARGLKVLFSSDTLFEVHDSSINVVDIVKQHCSCAMWKPTGLPCHHAVAVFNCTGRSVYDYCSKYYTAESFRLAFAESINPASTIAHPCGNEEDSEEDEDQIMPPSISRPVAAQQPKKIRRNKSQGIIRRSVCCTRCKGVGHNKVSCKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3W8</accession>
    <name>A0A0D2R3W8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G107900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R3W8"/>
    <dbReference type="Gramene" id="KJB14030">
        <property type="protein sequence ID" value="KJB14030"/>
        <property type="gene ID" value="B456_002G107900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEEVMKW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000060">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF229">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 73C3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB14030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="403" mass="44930" checksum="2E4E19EA9C13CC6E" modified="2015-04-29" version="1">MAQGHLIPMVDIGRLFAQRNVIVTIVTTPHNASRVQKTIDRAVESGLAIRLVQLRFPGKEAGLPDGVENMDMISSMEDYMDEAVQELYEKLTPGPICIISDFFLHYTLKIATKFQVPRISFHGICCFCYLCVHNLKSSKILDNITSDYECFKVPGLAEKVEFTKPQLPLNLDESWKDIFDTTTKADEASYGVVINSFEELESPYVKEYRKITKAWCIGPVSLSHKNELDKAERGKKASINEQQCLKWLDSQEPNSVIYACLGSMSTMKSPELIGLGLGLEASNKPFIWILRGNNDASNQVTKWIEEDGFEERIKGRGFVVVGWAPQVLILSHPAIGGFLTHCGWNSTIEGISAGVPLLTLPLFADQFTNERLVVQILKTGVSVGADEPTAWGEEKSGFKLTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R8E9</accession>
    <name>A0A0D2R8E9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF4378 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G030500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R8E9"/>
    <dbReference type="STRING" id="29730.A0A0D2R8E9"/>
    <dbReference type="Gramene" id="KJB28149">
        <property type="protein sequence ID" value="KJB28149"/>
        <property type="gene ID" value="B456_005G030500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796510"/>
    <dbReference type="eggNOG" id="ENOG502QV0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="770239at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022212">
        <property type="entry name" value="DUF3741"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025486">
        <property type="entry name" value="DUF4378"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212">
        <property type="entry name" value="ADHESIN-LIKE PROTEIN, PUTATIVE (DUF3741)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47212:SF4">
        <property type="entry name" value="ADHESIN-LIKE PROTEIN, PUTATIVE (DUF3741)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12552">
        <property type="entry name" value="DUF3741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14309">
        <property type="entry name" value="DUF4378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3741" evidence="2">
        <location>
            <begin position="213"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4378" evidence="3">
        <location>
            <begin position="754"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB28149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="922" mass="104168" checksum="F4249551A4CEEF23" modified="2015-04-29" version="1">MAKRSNRRTVRYERDQMGCMWGLITMFDFRHGRSTQRLLSDRRRGNRNVVGMGNSGNKIDMSTSSGEDKAMAMDTCKPSVKKLLEEEMSREHATKEEVNNTELDAKQFDSGEGDNERKNQKRRNKTRKKSSGGSLDVDAAKTLVSEISCYHKSEQQTTSNLDIENLVEELCQEMGQKRIDCVNRDQPVEGHMQPNMKSSRFEEMSEAIKFLVSQKLINRNQLTEGGELQASKEAMDALQILSLNEELFLKLLRDPNSSLVKNSKNSPNARDEESKPFSRSNFSEQEPVGLRQLNETVNRKQRNFFRRKSKSLERDLSDEQKVSEASTKIVVLKPGPTCSQTAETGSSIGSSPESKNIIRRREPNEKVGSHFFLSEIKRKFRHAMGREHHRIPAKEIPKRLSGERQSSSDNGGLKEYIGMNSPTKDHFFIERIAKPSSSVKKGEKTSKLKGPESSTEYETTHFSRHSNIYIEAKKHLSEMLTNGDDIMDLSGRQVPKTLGRILSLPDYNSSPIGSPARNPEPSSITAQSRFASPDKLQKLQNNVSNLSQSAEEPESRPGVSDNKNGDEVRGDNAILNKLDACVNDDTEDQSHSSSTKDEMGCEVYAGEVIVVEETEITVEEETELLDASSETNDYSITRDDKNVDMSEVYDEKQYPECSKQDLTEEDQQLFSPLASPSNSSLTKKVEGLEERPSPVSVLEPIFAEDVISPASIRCISGETSMQPLRIRFEEHGGSLATNCSNRFKTCMDDKESIYEYVKAVLEASSFEWDEFYIRSLSSDMLLDPLLLDEVEYLPNQLCHDKNLLFDCINEVLVEVCGYYLGSPGVSFVKTNIRPIPNLKNTIEEVWQGVYWHMLPMPLPRSLDQIVRKDMAKAGTWMDLRLDTDCIGGEISEAIFEDFVEDTITSYLNVSLECEYHAEGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9Z4</accession>
    <name>A0A0D2R9Z4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G062000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9Z4"/>
    <dbReference type="SMR" id="A0A0D2R9Z4"/>
    <dbReference type="STRING" id="29730.A0A0D2R9Z4"/>
    <dbReference type="Gramene" id="KJB28664">
        <property type="protein sequence ID" value="KJB28664"/>
        <property type="gene ID" value="B456_005G062000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796855"/>
    <dbReference type="eggNOG" id="KOG1696">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QARCRKN"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_eL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023638">
        <property type="entry name" value="Ribosomal_eL19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00526">
        <property type="entry name" value="RIBOSOMAL_L19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="149"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB28664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="206" mass="24100" checksum="808DDFCF1E56FD92" modified="2015-04-29" version="1">MVSLKLQKRLAASVLKCGRGKVWLDPNEINEISMANSRQNVRKLVKDGFIIRKPTKIHSRSRARRMKEAKRKGRHSGYGKRKGTREARLPTKILWMRRMRVLRRLLRKYRESKKIDKHMYHDMYMKVKGNVFKNKRVLMESIHKSKAEKAREKTLSDQFEAKRAKNKASRERKMARREERLAQGPGVKAAPAAAPQQAEGVKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RB41</accession>
    <name>A0A0D2RB41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleotide-sugar transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G264400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. CMP-Sialate:CMP antiporter (TC 2.A.7.12) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RB41"/>
    <dbReference type="Gramene" id="KJB26871">
        <property type="protein sequence ID" value="KJB26871"/>
        <property type="gene ID" value="B456_004G264400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26872">
        <property type="protein sequence ID" value="KJB26872"/>
        <property type="gene ID" value="B456_004G264400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26874">
        <property type="protein sequence ID" value="KJB26874"/>
        <property type="gene ID" value="B456_004G264400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792736"/>
    <dbReference type="eggNOG" id="KOG2234">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="419167at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB26871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="44122" checksum="CB4FC7A954EEDE9A" modified="2015-04-29" version="1">MIECSVCHSKIEPPASKSISRAYDKHRTFVSSKNRFLNVILVAGDCLLVGFQPILVYMSKVDGGFKYSPISVNFLIEVAKVIFAVVMLLFQSRHKKVGEKSLLSVSALVQAARNNVLLAVPALLYAINNYLKFIMQLYFNPATVKMLSNLKVLVIAILLKMIMKRKFSILQWEALALLLIGISINQLRSLPEGASSFGLPVATGAYLYTLIFVTVPSLASVFNEYALKSQFESSIYHQNLFLYGYGAMFNFLAILGIAIFKGPSSLDILQGHSKATMLLICNNAAQGILSSFFFKYADTILKKYSSTIATIFTGIASAVLFGHTLTINFVLGISVVIISMHQFFSSYSKVKDEQRSGNFKMVESIDSQRSRDASFPNKTDVSENASHHVNEEKGPLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDC3</accession>
    <name>A0A0D2RDC3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD finger protein ALFIN-LIKE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G120300</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Histone-binding component that specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the Alfin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDC3"/>
    <dbReference type="STRING" id="29730.A0A0D2RDC3"/>
    <dbReference type="Gramene" id="KJB29834">
        <property type="protein sequence ID" value="KJB29834"/>
        <property type="gene ID" value="B456_005G120300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1632">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15613">
        <property type="entry name" value="PHD_AL_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000306">
        <property type="entry name" value="PHD finger alfin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045104">
        <property type="entry name" value="Alfin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021998">
        <property type="entry name" value="Alfin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044104">
        <property type="entry name" value="PHD_AL_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12321">
        <property type="entry name" value="CPG BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12321:SF60">
        <property type="entry name" value="PHD FINGER PROTEIN ALFIN-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12165">
        <property type="entry name" value="Alfin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB29834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="290" mass="32869" checksum="A2B9B545F07E48E6" modified="2015-04-29" version="1">MEGVPHPIPRTVEEVFNDFRGRRSGLIKALTTDVDKFYQQCDPEKENLCLYGLPNETWEVNLPVEEVPPELPEPALGINFARDGMQEKDWLSLVAVHSDSWLLAVAFYFGARFSFGKNERKRLFRMINELPTIFEVVTGNVKQPTEQYANHNSSGKSKSSAKVVQSSKIETWMFFSVVFSSPLYVLLLIDVTFMASYACCWQSRQSESESKVVKMSASKDEDESGEDEEDDEQGATCGACGDSYGTDEFWICCDICERWFHGKCVKITPAKAEHIKQYKCPSCSSKRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDE7</accession>
    <name>A0A0D2RDE7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G099800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDE7"/>
    <dbReference type="STRING" id="29730.A0A0D2RDE7"/>
    <dbReference type="Gramene" id="KJB17200">
        <property type="protein sequence ID" value="KJB17200"/>
        <property type="gene ID" value="B456_002G099800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000779">
        <property type="term" value="P:regulation of double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044198">
        <property type="entry name" value="DEK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468:SF22">
        <property type="entry name" value="DEK DOMAIN-CONTAINING CHROMATIN-ASSOCIATED PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13468">
        <property type="entry name" value="DEK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB17200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="130" mass="14429" checksum="074CE2807505BD49" modified="2015-04-29" version="1">MVVNKCKMDLQEDIIAKLIDFLEAPHATTAILLAEKDKVLNFNCSFCQLSIFTHFLRYSFCLLSSLVGVESGKGLPGKMVAKGKDKAKKRKVKPSDYELRTTICGILKEVDFNTVRSATNLVPIMAESVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RII5</accession>
    <name>A0A0D2RII5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G100500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RII5"/>
    <dbReference type="STRING" id="29730.A0A0D2RII5"/>
    <dbReference type="Gramene" id="KJB29436">
        <property type="protein sequence ID" value="KJB29436"/>
        <property type="gene ID" value="B456_005G100500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032010">
        <property type="entry name" value="APD1-4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032008">
        <property type="entry name" value="APD1-4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858:SF6">
        <property type="entry name" value="LIGASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46858">
        <property type="entry name" value="OS05G0521000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16041">
        <property type="entry name" value="APD1-4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16040">
        <property type="entry name" value="APD1-4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB29436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="419" mass="47766" checksum="7010208998054056" modified="2015-04-29" version="1">MFRPGFVRASNHAQLPQWKDTWTRVLPALTLWICVSVILRYGYYGNCSMVLGPSSSRLMKASSVFVQQVQVRDENWKGALVYMFSEKPELSNEVNWNFSNYLIVGAYARKGYSLWLNKGSRICIRWATQPSRLDKIELIIIKGEKKRETLLPEQTVPFGALFLNEPVTGKEADYNIEEDDKYSVGLINSNPRSIIITFSLNVTSKVYDVTKASDMCSTLNGSCRLQLQFPHTQYVIVSTPDNGDIAGRYVELSFVARVVTYIAILGFFIIIILLVLKYLGACNDERTVINSNTTFREISWTETDPILLEKSVRLTYGTTAEDDNDDAETGSSSSSSEDLYDAKLCVICYDDQRNCFFVPCGHCATCYDCAQRYKQEEKKRNLLSLLSLTNKNCRIMEEDNKVCPICRRLIHKVRRLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIZ5</accession>
    <name>A0A0D2RIZ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UTP25 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G081200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIZ5"/>
    <dbReference type="STRING" id="29730.A0A0D2RIZ5"/>
    <dbReference type="Gramene" id="KJB19025">
        <property type="protein sequence ID" value="KJB19025"/>
        <property type="gene ID" value="B456_003G081200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2340">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLGMKQI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 C-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB19025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="8393" checksum="F67C4D9DC8EECACB" modified="2015-04-29" version="1">MLAGIRGIRNLIIYSLPERKEFYYEIVNMLEGSDDLACTVLFSQYDKLQLERIVGTAPAKRMIKSEKGVFVFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RML8</accession>
    <name>A0A0D2RML8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G127300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RML8"/>
    <dbReference type="Gramene" id="KJB33069">
        <property type="protein sequence ID" value="KJB33069"/>
        <property type="gene ID" value="B456_006G127300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8717" checksum="C749797016D78248" modified="2015-04-29" version="1">MGITILLNLQNSTSPSPFFLDGRRQPSEKPLMHGRNQPVCTNIVVTNTIAKLKVIAPVHYWNGVIWPKQPVTLVEIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RPD2</accession>
    <name>A0A0D2RPD2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_006G028300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RPD2"/>
    <dbReference type="Gramene" id="KJB33739">
        <property type="protein sequence ID" value="KJB33739"/>
        <property type="gene ID" value="B456_006G028300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797832"/>
    <dbReference type="eggNOG" id="ENOG502QVJM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IGNGRIW"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF149">
        <property type="entry name" value="TRICHOME BIREFRINGENCE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002263099" evidence="7">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="8">
        <location>
            <begin position="80"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="350" mass="40298" checksum="9A12D3AF08F07BF0" modified="2015-04-29" version="1">MGPFAFATSLFLFLIEICQQVDGIGSKCDIYKGKWVFDASYPLYNSSNCPFIHQEFNCQNNGRPDRLYQNFRWQPTSCNLPRFNGKDFLRKFRGKRIMFVGDSLGLNQWQSLSCLLHTATPQDPYISQRVAAISTFSFPTYGVSIMFLRNAFLVDIVNKKDRRVLKLNSIGNGRIWKGYDVLIFDTWHWWLLTGRKQPWDYVQDNNITRKDMNRTVAYKKALRTWARWVNLNVDPAKTKVFFQGVSPDHVDSRDWADPTAKTCRGETWPILSTEYPGGSPSPQDVLKRVLRIVSKKVHLLDITGLSQLRKDGHPSAFGYGGHRGNDCTHWCLPGVPDTWNELLFATLIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRE6</accession>
    <name>A0A0D2RRE6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G066000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRE6"/>
    <dbReference type="STRING" id="29730.A0A0D2RRE6"/>
    <dbReference type="Gramene" id="KJB34444">
        <property type="protein sequence ID" value="KJB34444"/>
        <property type="gene ID" value="B456_006G066000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHTPREF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044576">
        <property type="entry name" value="At4g25390-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46821">
        <property type="entry name" value="OS07G0586332 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46821:SF7">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB34444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="645" mass="72364" checksum="5ABEF34D7353468E" modified="2015-04-29" version="1">MMPRSLPPLQQPPLTHHRPLPIRLILPPIVAFTAAFSILLVLSLCLRKIRRERTVPADSKPPYRFSYSVLRRATSSFSVSQRLGQGGFGSVYRATISNNLHHDHRRSKNIQTVAVKVMDTSSLQGEREFQNELFFVSKLNSSLVVPVLGFSHDRKRRRMLLVYELMPNGNLQDALLHRKCPELMNWKQRFSVAVDIAKGVEYLHGLDPPVIHGDIKPSNILLDQYFSAKIADFGLARLKSEEVKLEIAEDHGSIAETESVATGFEDYGSIAENSEVVTVAVSPPAVATSPEIMEKGSVSVSEGNFDRASVENGKELVNGGGKQSGGSSSDWWWKQDMGAVGESGKVKDYVMEWIGSEIKKERPSNDWITSVASSSYEMKAKSGEKKNKKSKKRLEWWVSMEDDKENNVKRRPTRERWKEEYCAKLSKTNKKKKREMAMCHSDDNGGWENWWRLDDARKKKKRSKSSIGSVDWYDSFSGEIPKSGGISSTPSMRGTVCYIAPEYGGSDPSEKCDVYSFGVLLLVLIAGRRPLQVTGSPMAEFQRANLTSWAKHLAQTGKLFDLIDQSIQSLKQEQALLCITVALLCLQKSPARRPSMKEVVAMLTGDADPPQLPTEFSPSPPSRYPFKSRKKVRSSLLILLAWTCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRV2</accession>
    <name>A0A0D2RRV2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G075800</name>
        <name evidence="4" type="ORF">Gorai_000509</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRV2"/>
    <dbReference type="Gramene" id="KJB34624">
        <property type="protein sequence ID" value="KJB34624"/>
        <property type="gene ID" value="B456_006G075800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798848"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HLINCYV"/>
    <dbReference type="OrthoDB" id="1850776at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF368">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="92"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="330"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0587377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="542" mass="60582" checksum="EF0DD7741C5BCE28" modified="2015-04-29" version="1">MKKRLSHNLVSAVNSLHLSGSSKPLSFHKKTRFIQTVQTCNNLVLPTLTHSKILKSGLLNDTIITNHLINGYIKSQQISQAHQVFDEMPEPNVVSYTSLMSGYISASTPQLCLWMFREMHNSPVLPNDFTFATAVNACSILADLQKGKQVHGLVEVFGFRFNLVVCSSLVDMYGKCNEVDFAQLVFDSMADKNVVSWTSMITAYAQNGRGNEALEVFREFNLLDWEIPNKFMLASVINACASSGKLVSGKTTHGAVIRHGHDSNDVVASTLVDMYAKCGCIVYAARVFRRVRNPCVIPYTSMIVAAGKHGLGKVSIELFEEMIDKRIKPNDVTFVAVLHACSHSGLVDQGLEYFNSMSWKHGVVPEAKHYTCVVDMLSRIGRFDEAYRLAKSIKVNPNEGASLWGTLLSASRLHGRLDIAVEASKRLIESDQQVDGAYVTLSNAYVLAGEWENANDLRKKMKQTGVCKEPGCSWIDIKDSTYVFYAGNISFKRGTEVLRMLKELEREMKEKGRSKGLVFVDVEEEAMEETVDHWLKRLNREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSR8</accession>
    <name>A0A0D2RSR8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histidine kinase/HSP90-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G034000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSR8"/>
    <dbReference type="STRING" id="29730.A0A0D2RSR8"/>
    <dbReference type="Gramene" id="KJB22185">
        <property type="protein sequence ID" value="KJB22185"/>
        <property type="gene ID" value="B456_004G034000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0019">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSMAGHI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000357">
        <property type="entry name" value="Heat shock protein HSP 90-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="188"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="641"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="120"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB22185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="666" mass="76096" checksum="9C7FF79B17BDA60F" modified="2015-04-29" version="1">MADTETFAFQAEINQLLSLIINTFYSNKEIFLRELISNASDALDKIRFESLTDKSKLDAQPELFIHIIPDKTNNTLTIIDSGIGMTKADLVNNLGTIARSGTKEFMEALAAGADVSMIGQFGVGFYSAYLVAEKVIVTAKHNDDEQYVWESQAGGSFTVTRDTSGENLGRGTKITLFLKEDQLEYLEERHEEDKKDEEGKVEDVDEEKEKEEKKKKKIKEVSHEWSLVNKQKPIWMRKPEEITKEEYAAFYKSLTNDWEEHLAVKHFSVEGQLEFKAVLFVPKRAPFDLFDTRKKPNNIKLYVRRVFIMDNCEELIPEFLSFVKGIVDSEDLPLNISREMLQQNKILKVIRKNLVKKCIELFFEIAENKEDYNKFYEAFSKNLKLGIHEDSQNRTKIAELLRYHSTKSGDELTSLKDYVTRMKEGQNDIYYITGESKKAVENSPFLEKLKKKGYEVLYMVDAIDEYAVGQLKEFEGKKLVSATKEGLKLDESEDEKKKKEALKEKFEGLCKVIKDVLGDKVEKVVVSDRVVDSPCCLVTGEYGWTANMERIMKAQALRDNSMAGYMSSKKTMEINPENPIMEELRKRADADKNDKSVKDLVLLLFETALLTSGFSLDEPNTFGNRIHRMLKLGLSIDEDAGEAEADADMPPLEDADAEGSKMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUR8</accession>
    <name>A0A0D2RUR8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_011G284800</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUR8"/>
    <dbReference type="STRING" id="29730.A0A0D2RUR8"/>
    <dbReference type="Gramene" id="KJB74482">
        <property type="protein sequence ID" value="KJB74482"/>
        <property type="gene ID" value="B456_011G284800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHGEDER"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000288">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase EFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052:SF66">
        <property type="entry name" value="OS02G0610000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48052">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="20">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="21">
        <location>
            <begin position="61"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB74482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="730" mass="79069" checksum="D8B3993E96D876E9" modified="2015-04-29" version="1" fragment="single">QVFSKTPTGLVVRGNDTDQQALLQFKAKITDDRLRVMESWNSSIHFCQWHGVTCGRKHQRVTKLELQSLKLSGSLSPHIGNMSFLRVLNLLNNSFYNQIPQSIDGLRRLDTLYLTNNSISGEIPSNLSSCSNLTIVRMAGNRLTGEIPAFLGFLSNLKVLSFYNNSLKGSIPPSLGNLSSLEELALTYNALDGIIPETLGRLTNLSIFLAAANAISGTLPVAMFNLSNIRFFDIGENKIQCTLYTDLAITMPYVEFFSVRGNKISGQIPISITNASNLHVLQFNDNRLSGKVPSLEKLDKLSTLQLTVNGLGHGREGDLNFLCTLVNNTKLEFLFISDNNFGGVFPKCVSNFSNTLLQLEIDENKIMGRIPDGIGNLVNLEVLYASENQMSGPIPFEIGRLQKLNKFFAHINFLSGTIPHSIGNLSALTIVGLDFNNLQGNIPLSIGKCQSLLELTVSYNNLSGPIPPQLLGVSSMSIILDLSSNHLTGELPVAVENLKNLGQLYVSQNRLSGLLPKTLGSCVSLEKLFLDGNLFEGPIPSSLSSLRGLEALDVSNNNLSGEIPEFLVGFGALRYLNLSFNNFEGVIPSGGIFKNASATLVEGNSKLCGGIPELHMLRCNLKTSSSNSLRLKVAIIVATLGVTLAFTCLLILWIGKKKEKQATATSVENSVLQLSYQSIVRATDGFSTQNLVGSGSFGSVYKGVLEASGAVIVVKVLNLLNRGASMEFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RWB3</accession>
    <name>A0A0D2RWB3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G030500</name>
        <name evidence="6" type="ORF">Gorai_000232</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RWB3"/>
    <dbReference type="STRING" id="29730.A0A0D2RWB3"/>
    <dbReference type="Gramene" id="KJB33786">
        <property type="protein sequence ID" value="KJB33786"/>
        <property type="gene ID" value="B456_006G030500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798323"/>
    <dbReference type="eggNOG" id="KOG1502">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAMGNNT"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000388">
        <property type="entry name" value="Cinnamoyl-CoA reductase-like SNL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF483">
        <property type="entry name" value="CINNAMOYL COA REDUCTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB33786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0587096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="360" mass="39956" checksum="E7162EB2B6CF3AB3" modified="2015-04-29" version="1">MGIARTHDEDYETREFKTLVALAAMERRKDNGEFKGLTSHSSIVDLQDKLVCVTSGASFFGFALVNRLLLHGYFVRVLVANQEDVEKLREMEISGEMMGCKSKISVVVAKPNEIQGLMEAFDGCCGVFHTSSFADPAGLSGYSKSMAEMEGKASENVMKACARTPSVKHCVLTSSLLACIWRDNSQYEFPPLVNHNCWSNESLCVDKKLWYALGKLKAEKVAWKIAEEMSLNLTTICPGLITGHEFSYRNPTATIAYLKGAQEMYANGLLATVDVRRLAEAHVSVFEAMKTTTAFGRYICFDRIIQCEDEAEKLADEIGIPRNKISGNSSDCVFPNCFELSNKKLANLMSRTLRSCYGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RYD8</accession>
    <name>A0A0D2RYD8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Band 7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_004G126000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYD8"/>
    <dbReference type="STRING" id="29730.A0A0D2RYD8"/>
    <dbReference type="Gramene" id="KJB24055">
        <property type="protein sequence ID" value="KJB24055"/>
        <property type="gene ID" value="B456_004G126000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791254"/>
    <dbReference type="eggNOG" id="KOG2620">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMNMQLK"/>
    <dbReference type="OrthoDB" id="434619at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08829">
        <property type="entry name" value="SPFH_paraslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000008">
        <property type="entry name" value="Stomatin-like protein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050710">
        <property type="entry name" value="Band7/mec-2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032435">
        <property type="entry name" value="STML2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43327:SF10">
        <property type="entry name" value="STOMATIN-LIKE PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16200">
        <property type="entry name" value="Band_7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="65"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="351"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="409" mass="44853" checksum="9E47441AF40D9D0D" modified="2015-04-29" version="1">MSKMLRVGSLKNAVTTLRYLQESSFSTAVIRQHSSSAPPFATTVRHLRTGRDPSFRYETSPPVNWGIRIVPEKKAYVIERFGKYLKTLPSGIHFLIPLVDRIAYVHSLKEEAIPIPDQSAITKDNVSILIDGVLYVKIVDPKLASYGVENPIYAVIQLAQTTMRSELGKITLDKTFEERDTLNEKIVEAINVAAKDWGLQCLRYEIRDISPPRGVRAAMEMQAEAERKKRAQVLESEGERQSNINIADGRKSAVILASEAARMDQVNRAQGEAEAILARAQATAKGIALVSQSLKENGGVEAASLRIAEQYIQAFSNIAKEGTTMLLPSSAANPANMIAQALTMYKSLVSNSSTGDSHVNNSLELSRSTKHAPPGETEGEIPNPRAVEARDTNHVGEVGFSLQSSKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3F8</accession>
    <name>A0A0D2S3F8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TRAF-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G145500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S3F8"/>
    <dbReference type="Gramene" id="KJB36186">
        <property type="protein sequence ID" value="KJB36186"/>
        <property type="gene ID" value="B456_006G145500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSC3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EQKCTAN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF161">
        <property type="entry name" value="F26K24.24 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TRAF-type" evidence="6">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="144"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB36186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="428" mass="48161" checksum="46B5F149BAFB161A" modified="2015-04-29" version="1">MVEYLTQRSETFVAESVVLDAGLEVQASDHPYDIIAFLIDEFATTKRNLFSRVSEWLLSDKREDKIDDFSQEMEINGFWSIDKREAIVQTLLKNVDLKNEFHCDMKFYSADELAQHVPTCKYRSMTCQNEGCYAKYSISQMENHDSVCPYKMIPCEQKCLASLMRRDMDRHCITVCPMKLVNCPFYSVGCKSAIPQCKIEEHRSLDFHSHLLYILQGIHKEASVEVLRKRVEQLLQKYSSKLANIRDLRSLTYKVKDLDAKLGPLKVCATNEVDVATKTAGKLQILEASDTNKVTEKGAETRVVGFEAKPQSLEVTPTNKDSIEAVKAEIKDSEAKLQSLGVKSLNKVSKEGLKTKATDVEAKPQSLENTITNKDSGVAPGTTVNHHEARPPSLEVTPKKVSEATIENSVKDVEGKVRLSKVSTGENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S5Y1</accession>
    <name>A0A0D2S5Y1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G219200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S5Y1"/>
    <dbReference type="STRING" id="29730.A0A0D2S5Y1"/>
    <dbReference type="Gramene" id="KJB58636">
        <property type="protein sequence ID" value="KJB58636"/>
        <property type="gene ID" value="B456_009G219200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58638">
        <property type="protein sequence ID" value="KJB58638"/>
        <property type="gene ID" value="B456_009G219200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769331"/>
    <dbReference type="eggNOG" id="ENOG502QWJS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MYNWSLA"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21546">
        <property type="entry name" value="SPOC_FPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012921">
        <property type="entry name" value="SPOC_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF2">
        <property type="entry name" value="NUCLEIC ACID BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07744">
        <property type="entry name" value="SPOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="580"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="394"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="886"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="946"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="409"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="952"/>
            <end position="996"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1159" mass="126579" checksum="00D717B92CE475B1" modified="2015-04-29" version="1">MAMSSSEQPLKKRRLFDPPPDTVSQPETSVAPPTTPPPLSQEEILLRRRNRDEIRSVYENYKRIKSCISLKGKDARCMPELEQAYHALITASRGCLSVQRLVADFVPRYASHCPTALESATKAIIDVHNSSLAVISRGEDADNVAFQTAKACIFGLADICSTASIEAPSSLVARGICSTVFQNVLSFLIASFQGKDLFQIVDRDICKILDSDEMFSKLKQKFSDEDESSLIKLFKLQILSLLRILFCCPKKLLSACFELFRSSETDEADKGLYFLRQATGRLDDLDPTFGLDKIKVEPKSCMDSLGTSTKTSVLTGETPGSDSCTAIEDSSSVLKSSLLGLVFGKNPSLRNWMLLKYKKLCKSSPSKSVPEIVSSLEGIFELFGKGINMEASLVDSDEDDSDSSKFSSQPNLISRSSNQHETLSDQSGRGKSSNETCIENLSGQYLNPHIVPPETNLHLNAGSSHDSGGSRSVDFERHDHGDLTSSRSSVPRDQSSHQLLSPATRTPRDLRGNSFEGRNHFKNVDMSQGSNSSGTSALRSASGGVSNALASPSNRYGASSLSVWYFDSDPASLGVFSASRQLWLGSLGPDASEGYIRFELERFGPVEQFFFFQVKGFALVEYRNIIDSIRAREYIRGCFPWQVMFMDIGLGTRGSVNGVAVGSSSHVYVGNISSQWAKDETLHESRKVIYKGPYMVIDLTCECALLLEYETPEEAAAVMAHLRQHRKERNGHMPPFNAAPPSVSMPHVDSGRSGAAPPIHADIINNTSGNMSSSSMELVSPKLRMENHGTPAPGAHPFQSNWPPEGAVRKGDGYDNNLIADPAQGGGGAVSGASAQVWSYQKPESEMHSAPGSMPCMPIATQNLTAPPPPPQLQAPPFMRPVYHPPNSSWDPRGLNHQFPQNPISPGVVPNTFHGNAVPPPPPPPFVSASVTPLAQMQGPPVQHFEQRFPHPVVPPPLSSMPPPPPPPLSPPPLPQSLPPLVPPPPNSPPPPPPPIAESTDMGSSERCVKYQWQGSLCKSGAHYCTIYAQRLDSDLCKYSNASPEPTEWPAKLDMTKRTDFRHVKSTFTNTPPHKREVCCLIPSSTSDHKGFQDFISYLKQRDCAGVIKIPVVKSMWSRLLFILPYSQDACSMLSVVPPNASDCLIALVLPKETNFEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S6L9</accession>
    <name>A0A0D2S6L9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP synthase subunit a, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">30S ribosomal protein S2, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_013G017800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATPase A chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S6L9"/>
    <dbReference type="STRING" id="29730.A0A0D2S6L9"/>
    <dbReference type="Gramene" id="KJB78767">
        <property type="protein sequence ID" value="KJB78767"/>
        <property type="gene ID" value="B456_013G017800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0832">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4665">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVISELT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00310">
        <property type="entry name" value="ATP-synt_Fo_a_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000008">
        <property type="entry name" value="30S ribosomal protein S2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.220:FF:000001">
        <property type="entry name" value="ATP synthase subunit a, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="entry name" value="ATP synthase, F0 complex, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823:SF3">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT A, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="F1F0 ATP synthase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0138">CF(0)</keyword>
    <keyword evidence="8" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00035546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00074744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB78767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="425" mass="47381" checksum="4E8D3E755A50D4C1" modified="2015-04-29" version="1">MARRYWNINLEKMLEAEVHFGHGTRKWNPRMVPYISEKRKGIHITNLTRTARFLSEACDLVFDAASKGKQFLIVGTKNKAADSVARAPTTKMRLHKFRDLRTEQKTGGLNHLLKRNVAILLDIVIIVDQQEEYTALRECITLVIPTNCLIDTNSDSDLTDISIRTNDDAIASIRLLLNKLVVTIFLFLLEGNMNGVSNALNRLYDISGVEVGQHFYWQITGFQVHPQVLITSWVVIAILLGSAIIAVRNPQTITTAGKISSNIIWSMGSLYWNYVSIIFVSNWSGALLPWKIIQLPRGELAAPTNDINTTVALALLASVAYFYAGLSKKGLGYFSRYIQPTPILLPINILEDFTKPLSLTLCLVGFRLFENILADELEVVVIVSLVPSVVPIPVMFHGLFTSGIQALIFATLAATYIGESMEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S762</accession>
    <name>A0A0D2S762_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G207800</name>
        <name evidence="12" type="ORF">Gorai_001465</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S762"/>
    <dbReference type="STRING" id="29730.A0A0D2S762"/>
    <dbReference type="Gramene" id="KJB37506">
        <property type="protein sequence ID" value="KJB37506"/>
        <property type="gene ID" value="B456_006G207800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800217"/>
    <dbReference type="eggNOG" id="ENOG502QTDE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFCHENK"/>
    <dbReference type="OrthoDB" id="785956at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051758">
        <property type="entry name" value="ERF/AP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31657:SF20">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB37506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0588357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="301" mass="33517" checksum="F6B926DC41C18A9F" modified="2015-04-29" version="1">MQEIYHPFGFNNGVDIGSSLSQIILSGGSNTLDSVFSHCASLPTAIATNSVYEPLGSSVYLRQRDLLQKFCHENKGNPSFSGKSVKGLLQNYPNPPSTTNYLSPPQKKKLYRGVRQRQWGKWVAEIRLPQNRVRVWLGTYDTAETAAYAYDRAAYKLRGEYARLNFPNTKDPSELGFADCAKLNALKNTVDAKIQAICQKVKRGKARKKAKRSPEAEKQAKVPEPCSSSSLLSPAVFSENLSNEWPSPSVSEDGFWRCGNSPSSVLNDYPSMITEEPMFEDCSLARMPSFDADLLWEILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S822</accession>
    <name>A0A0D2S822_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar iron transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G253300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Vacuolar Fe(2+) uptake transporter.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Fe(2+)(in) = Fe(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:28486"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:28487"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Vacuole membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the CCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S822"/>
    <dbReference type="STRING" id="29730.A0A0D2S822"/>
    <dbReference type="Gramene" id="KJB59408">
        <property type="protein sequence ID" value="KJB59408"/>
        <property type="gene ID" value="B456_009G253300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4473">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGGWLRP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140315">
        <property type="term" value="F:iron ion sequestering activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005381">
        <property type="term" value="F:iron ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="203" mass="21354" checksum="1267FDCE36650478" modified="2015-04-29" version="1">MELEPTDDFNYSKRSQWLRAAVLGANDGLVSTAALMMGVGAVKQDIKAMILTGFAGLVAGACSMAIGEFVSVYSQLDIEVAQLKRDKLRDENTETTDEEEEEKGSKGEKESLPNPLQASAASALSFSVGAMVPLLAASFIKEYKVRLGVVVGAVSLALAVFGWLGAVLGRAPRVRSAVRVLVGGWLAMAITFGLTKLIGSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S910</accession>
    <name>A0A0D2S910_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G053700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S910"/>
    <dbReference type="STRING" id="29730.A0A0D2S910"/>
    <dbReference type="Gramene" id="KJB79547">
        <property type="protein sequence ID" value="KJB79547"/>
        <property type="gene ID" value="B456_013G053700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782966"/>
    <dbReference type="eggNOG" id="ENOG502QRHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYMFDGE"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47468">
        <property type="entry name" value="OS08G0130000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47468:SF1">
        <property type="entry name" value="OS08G0130000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB79547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="51337" checksum="7B9147984EC02160" modified="2015-04-29" version="1">MDSVEEEVPSGGEMEELVRPSSTNVAASVNEHPTSHFSGMVRQKAYVFDGFGNYFNKDWDLGEGEGKEFCWYHVELPKVRQKCCQSAQHLIDVLCPPLKLQDILSLASNGPFCGHVDGALVFRVNSPGPISSSFTFRLAARITEKSVITVSLGRVPRLGFSPVGQSLLSEIPSVENPSNYKRGSTNRSGIVIKEHVLEFLLTMNHSEEADNPVPKSISNLVVHVIDTHVDHLEDVVTKLEMELETVELELDRGGFALKKEMLDDRRFPKMHLNLQRLLQVIAHGEQVFPRVKEKCLSKSWFLSKDINSLDELIGRLRRLKENVGFLANRVTAIQAGLDSWQSEQINKKLYYLSFLSIVFLPLSVITGVFGMNVGGVPWTMQNNPEVKDGFFKVMVLCVAMLLLVLLCFLFPILYSHVMAWYKKRFLRRTWSHNRRSCRRTIGIQERSCCPRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SCK5</accession>
    <name>A0A0D2SCK5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7733 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G120000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SCK5"/>
    <dbReference type="STRING" id="29730.A0A0D2SCK5"/>
    <dbReference type="Gramene" id="KJB80887">
        <property type="protein sequence ID" value="KJB80887"/>
        <property type="gene ID" value="B456_013G120000"/>
    </dbReference>
    <dbReference type="OMA" id="NWLRCEF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056635">
        <property type="entry name" value="DUF7733"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33829">
        <property type="entry name" value="OSJNBA0044M19.10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33829:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24867">
        <property type="entry name" value="DUF7733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7733" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="76" mass="8862" checksum="3744FE6A635EE6D1" modified="2015-04-29" version="1">MVYNTRIFSLVDWLRCGFTKVDNEYAGSGKRVYVGRVLALANMGFWCFNLFGFLLPVYLPKAFKMYYSETKVKVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SG51</accession>
    <name>A0A0D2SG51_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF241 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G189600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SG51"/>
    <dbReference type="STRING" id="29730.A0A0D2SG51"/>
    <dbReference type="Gramene" id="KJB43234">
        <property type="protein sequence ID" value="KJB43234"/>
        <property type="gene ID" value="B456_007G189600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803662"/>
    <dbReference type="eggNOG" id="ENOG502QUY1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDCRVAM"/>
    <dbReference type="OrthoDB" id="1701699at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048367">
        <property type="term" value="P:shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004320">
        <property type="entry name" value="BPS1_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070:SF109">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF241)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33070">
        <property type="entry name" value="OS06G0725500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03087">
        <property type="entry name" value="BPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33396" checksum="9D1729C2AE303FB5" modified="2015-04-29" version="1">MGGKYHVRSISLPSRSHPTTLRIEDELNRLKAWEASSPLTTCESIFTCLSGLEDLYRCMGDLLSMPSTQQVLSQYHQHEKCVDELLDGSVRLLDICGIARDNMYEIKEHVHALQSALRRRKGDSSIEDNIVNYTKFRKQMKKKGKKLITELKQMGNKLGASPLLLDQHQDEDQYHHFLAVIRVLTQVNATTASIFQSFFSFLSAPVSSKQTRWSVVSKLMMHKGVISCEENVNELESVDAALCKHTSDVEKMQMAHKRLVELESGIEGLEKRLECVFRRLIKARTSLLNMISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGH4</accession>
    <name>A0A0D2SGH4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zinc knuckle CX2CX4HX4C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G136600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SGH4"/>
    <dbReference type="STRING" id="29730.A0A0D2SGH4"/>
    <dbReference type="Gramene" id="KJB30305">
        <property type="protein sequence ID" value="KJB30305"/>
        <property type="gene ID" value="B456_005G136600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EYQEDYS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040256">
        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025836">
        <property type="entry name" value="Zn_knuckle_CX2CX4HX4C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF178">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14392">
        <property type="entry name" value="zf-CCHC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zinc knuckle CX2CX4HX4C" evidence="2">
        <location>
            <begin position="97"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB30305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="168" mass="19767" checksum="FD89508A3C9F815F" modified="2015-04-29" version="1" fragment="single">FEYQEDYSRILNLTPWLFDRCLFSMLPFEEGNDIDSYQFWWLPFWLRIYNIPLELMDRQIALNVGDALGELVAIDWKDHNGGWTEFIRLKVKINVLKPLRGVVKLLDREGTKVTGVINYERLPDFYYGCGLIGHSSKTCKYNKGEPNPRQRHENKWGRTSEAKGSNEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHT2</accession>
    <name>A0A0D2SHT2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G431000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHT2"/>
    <dbReference type="STRING" id="29730.A0A0D2SHT2"/>
    <dbReference type="Gramene" id="KJB62698">
        <property type="protein sequence ID" value="KJB62698"/>
        <property type="gene ID" value="B456_009G431000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="8995" checksum="AC8E503A6C3B01AF" modified="2015-04-29" version="1">MEKALLEALFGFHFAFAQNPFDASFRPRYGRSFRGIPVLVMPEASQPQSLKPKMVSIPVHFVGSERGRSDSAIKIQKGASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHZ7</accession>
    <name>A0A0D2SHZ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G434800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHZ7"/>
    <dbReference type="STRING" id="29730.A0A0D2SHZ7"/>
    <dbReference type="Gramene" id="KJB62758">
        <property type="protein sequence ID" value="KJB62758"/>
        <property type="gene ID" value="B456_009G434800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SCHAPEF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000126">
        <property type="entry name" value="Predicted protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951:SF8">
        <property type="entry name" value="CYTOCHROME P450 93A2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951">
        <property type="entry name" value="OS08G0547900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB62758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="37628" checksum="72D0F55D2FF03D4F" modified="2015-04-29" version="1">MQLSATALRVMMSTLWGDDPSQDLIEFRKRLDEIVITFAAPNVSDFFPILAPFDLQGIESKGKEQVSWFYGVFESMIKNRRNIRDDGKEKENISKDFMQQLLELHWRGDEKNSLSINEVKALLLDMMLAGTDTIPTAVEWAMTELLRHRDKMTKLVKELDMVVGNQNTVEDSHIPQLVYLDAVIKETLRLHPVAPLLIPHVPSETTVIGGFTVPKGCRVFINAWVIQRDPELWDDPLRFHPERFLETDINYRSNNFGFFPFGSGRRICVGVSLAEKMMALLLGSLVHSFEWGLSEGTKPSLEDKFGIVLKKTEPLVGIPVARLPNLEQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SK65</accession>
    <name>A0A0D2SK65_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_007G261000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SK65"/>
    <dbReference type="STRING" id="29730.A0A0D2SK65"/>
    <dbReference type="Gramene" id="KJB44614">
        <property type="protein sequence ID" value="KJB44614"/>
        <property type="gene ID" value="B456_007G261000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804456"/>
    <dbReference type="eggNOG" id="KOG1376">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCLENEW"/>
    <dbReference type="OrthoDB" id="6049624at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="49"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="248"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB44614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="449" mass="49593" checksum="D3DBC302628C2509" modified="2015-04-29" version="1">MREVISIHIGQAGIQVGNACWELYCLEHGIQPDGMMPGDTSVGACHDAFNTFFSETGSGKHVPRAIFVDLEPTVIDEVRSGAFRQLFHPEQLISGKEDAANNFARGHYTVGREIVDLCLDRIRKLADNCTGLQGFLVFNAVGGGTGSGLGSLLLERLSVDYGKKSKLGFTIFPSPQVSTAVVEPYNSVLSTHSLLEHTDVAVLLDNEAIYDICRRSLDIERPTYNNLNRLISQIISSLTTSLRFDGAINVDITEFQTNLVPYPRIHFMLSSYAPVISAAKAYHEQLSVPEITSAVFEPSSMMAKCDPRHGKYMACCLMYRGDIVPKDVNAAVATIKTKRTVQFVDWCPTGFKCGINYQPPTVVPGGDLARVQRAVCMISNNTSVAEVFSRIDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGAEGGEDEEEPEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKA2</accession>
    <name>A0A0D2SKA2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G258200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with the GTPase NUG2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SKA2"/>
    <dbReference type="SMR" id="A0A0D2SKA2"/>
    <dbReference type="STRING" id="29730.A0A0D2SKA2"/>
    <dbReference type="Gramene" id="KJB83682">
        <property type="protein sequence ID" value="KJB83682"/>
        <property type="gene ID" value="B456_013G258200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783291"/>
    <dbReference type="eggNOG" id="KOG1570">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="14163at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_uL1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00062612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB83682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="216" mass="24476" checksum="1ADA06D904521452" modified="2015-04-29" version="1">MSKLQSDALREAISTIVANSKEKSRKFTETIELQIGLKNYDPQKDKRFSGSVKLPHIPRPKMKICMLGDAQHVEEAEKIGLDYMDVEALKKLNKNKKLVKKLAKKYHAFLASESVIKQIPRLLGPGLNKAGKFPTLVTHQESLESKVNETKAMVKFQLKKVLCMGVAVGNVAMEEKQIFQNVQMSVNFLVSLLKKNWQNVRCLYLKSTMGPSNRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNG0</accession>
    <name>A0A0D2SNG0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G323200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNG0"/>
    <dbReference type="Gramene" id="KJB45724">
        <property type="protein sequence ID" value="KJB45724"/>
        <property type="gene ID" value="B456_007G323200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761285"/>
    <dbReference type="eggNOG" id="KOG1479">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDCETAG"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF38">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOTIDE TRANSPORTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB45724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45950" checksum="58D1C3BD2FBFF73B" modified="2015-04-29" version="1">MTIVDGGESPSRLEGKISAMIVCWILGFGSLIAWNSMLTIGDYYYNLFPDYHPSRVLTLVYQPFAFGTMSILAYNESKINTRRRNIFGYSLFVASTFMLLVLDLATSGRGGLGSFIGICAIVAFFGVADACVQGGIVGDLSFMLPDFIQSFFAGLAASGALTSALRLITKAAFEMSNNGLRKGAMLFLAISTLFEFLCVLLYTYFFPKLPIVKYFRSKAALEGSKTVQADLAAAGIQTKDDHHEQNERLSNKQLFIQNIDYALDLFLIYVLTLSIFPGFLYENTGEHKLGTWYPLVLIASYNVWDLISRYLPLVKFLKIESRKGLTIAILSRFLLIPAFYFTAKYGDQGWMILLVSFLGLTNGHLTVCVMTAAPKGYKGPEQNALGNILVLCLLIGIFAGVSLDWLWLIGKKNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNS1</accession>
    <name>A0A0D2SNS1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G209700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNS1"/>
    <dbReference type="STRING" id="29730.A0A0D2SNS1"/>
    <dbReference type="Gramene" id="KJB43621">
        <property type="protein sequence ID" value="KJB43621"/>
        <property type="gene ID" value="B456_007G209700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803877"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VPRHTFQ"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF245">
        <property type="entry name" value="SKU5 SIMILAR 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251132" evidence="3">
        <location>
            <begin position="26"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="36"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="161"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="405"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB43621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="539" mass="60456" checksum="7E40194BD046A661" modified="2015-04-29" version="1">MKEATLLQFLLGIIVCSTLFFCTNAEDPYLFYTWEVTYGTRAPLGVPQQVILINNQFPGPPIEAVTNNNIVVNVINHLDEPFLITWHGIMQRRTSWQDGVLGTNCPIPPHSNWTYKFQVKDQIGTFMYYPSTLMHRASGGFGAFNINQRSVISIPYPAFDEDVTLLVGDWYIKGHKALQKQLDSGLDLPLPDGLLINGVSNFTFTGQKGKTYKFRVTNVGISTSINFRIQGHPMTLVEVEGCHTLQEVYESIDIHAGQSIAVLVTLHGSVKDYFIVASTRFTKPILTTTGILLYQGSQTPPSLPLPVAPTYHVHWSMKHARTIRMNLTANAARPNPQGSFHYGAIKVVRTILLANEKVEINDKLRYAVNGISYVDPATPLKLADWFNIPGVFVLNGTKDAPPSGPPTLGVSVFGLTLHDFVEIVFQNTEKTIQSWHLDGYNFFVAGYGGGNWTTDVRRRKRYNLVDAVSRSTVQVYPKSWTSILVSLDNKGMWNLRSQTWSKRYLGQEVYLRVWNDEKSLYTETDIPPNALFCGKAVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNW0</accession>
    <name>A0A0D2SNW0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G333200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNW0"/>
    <dbReference type="Gramene" id="KJB45854">
        <property type="protein sequence ID" value="KJB45854"/>
        <property type="gene ID" value="B456_007G333200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761369"/>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIRTCRM"/>
    <dbReference type="OrthoDB" id="646178at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098542">
        <property type="term" value="P:defense response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.430:FF:000003">
        <property type="entry name" value="Probable disease resistance protein At5g66910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23155:SF1185">
        <property type="entry name" value="DISEASE RESISTANCE RPP8-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="5">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="172"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="6">
        <location>
            <begin position="425"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="7">
        <location>
            <begin position="615"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB45854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="961" mass="111275" checksum="F9592AE2D11D9F9D" modified="2015-04-29" version="1">MAWSAVTSAVINIGKLLTEEAIYLWGVEEEVDRLQTELKWMQRYLTDAETKQSKEEMIRLWVAEIRELAYDAEDVVEEFALKIGSENKGCLPSCIKTSACCLKEGWALHKTRSKIEKIIERINDLVRRLQAYGVKELKDREEESSSSTERRESRRPYPHIMDDNIVGLVDDTEGLVKVLTNESRCQVVTIWGMGGLGKTTLAKKIYHDPQVRNYFEHFAFVYVSQPCQKRKVWEDILSGFKTLKDEDRKKRDEDLAEKLCNILEVKECLVILDDVWTREAWDSLKPAFPVATGRHRKSKILLTSRNRGIVSDAEIRELKCLNDQQSWELLQKIVSPKTGNIIDVKMIELGKNMVKHCAGLPLAIVVLGGILATKKNSLIEWQKISDNVKSYLKRGKNQGPEDVLALSYDDLPPYLRPCFLYLSHFPEDYMIDVDRLIQLWVAEGIVSSKEEERDGGEIAEDVAESYLMELVERCMIQVRERNVAASEIRATLKVKTIQMHDLIRDLCLSKAKQEKFVFIVDGSNASSLSMIRKVRRVSVHESFFIQCIKSPNIRSLLFFNQFFPEEALEKSFPLEVLNYVKKHCDDCCNPLFWILLISVGSTRRLKIREFWRYMFNNFKLLRVLNYDKGRTSYGFWTGWDLPSDIGNLIHLRFLSLKDLVFLWPKLQSSLGNLRCLQTLDLRVNFPEIHVPNVIWRMEQLRHLYLPFDCESSTKLNLGTLRKLLTLVNFNTKNCYLKDLINMTNLRELEINLPFNIENFNESGENPPIIGGKYLHSLFIIAIGESGSEIDPRHLAHLLSNCTSICQLSIAAEISKLPEYQYFSSHLAYIRLSWCKFEEDPMPTLEKLPNLRILEFKYTLEGKEMFCSAQGFPKLESLILEQLGKLEEWKVDEGAMPSLQRLEIRECGNLKMLPEGLRFITTLKELKIESMPKAFKDRLEEGGEDFYEVKHVPSIIFQNILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQ48</accession>
    <name>A0A0D2SQ48_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G095200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQ48"/>
    <dbReference type="STRING" id="29730.A0A0D2SQ48"/>
    <dbReference type="Gramene" id="KJB65438">
        <property type="protein sequence ID" value="KJB65438"/>
        <property type="gene ID" value="B456_010G095200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773668"/>
    <dbReference type="eggNOG" id="KOG2604">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DEFELWG"/>
    <dbReference type="OrthoDB" id="296793at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="9">
        <location>
            <begin position="117"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="10">
        <location>
            <begin position="286"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB65438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="784" mass="88519" checksum="AED6C07FCD6C88F5" modified="2015-04-29" version="1">MATNPAATPPNLPKSGAISKGYNFASTWEQNAPLTEQQQGAILMLSHAVAERPFPANLAQERTSGQDAGLSVSTKDNNFGDSGAIEAILVNTNQFYKWFTDLESAMRSETEEKYQHYVNTLTDRIQTCDDILRQVDETLDLFNELQMQHQAVATKTKTLHDACDRLVMEKQKLIEFAEALRSKLKYFDELENVTSNFYSPNMNVGNANFLPLLKRLDECISYVENNPQYAESSVYLLKFRQLQSRALGLIRSHVLSVLKRASSQVQTAIQSSGGNKASLSEGVEASVIYIRFKAAASELKPVLEEIESRASRKEYVHILAECHKLYCEQRLSLIKGIAHQRISEFAKKEGLPSLTRSGCAYLMQVCQLEHQLFDHFFPSSSEDVSSLAPLIDPLSTYLYDTLRPRLIHETNVDFLCELVDILKVEVLGEQLSRRSESLAGLRPTLERILADIHERLTFRARTHIRDEIANYIPFDEDLDYPAKLQHTADVKTETASADANPDVFKTWYPPLEKTVSILSKLYRCLESEVFTGLAQEALEVCSDSIQKASKLITKRSTPMEGQLFLIKHLLILREQIAPFDIEFSVTHKELDFSHVLEHLRRILRGQASLFDWTRSTSLARTLSPRVLESQVDAKKELEKSLKATCEEFIMAVTKQIVDPMLSFVTKVTAVKVALSSSTQNKKVDSVMAKPLKEQAFAAPEKVAELVQKVNSAIQQELPLVIAKMKLYLQNPSTRTILFKPIKTNIVEAHIQVQSLLKTEYSPDEKSTINMVNIQELEAQLDNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SW76</accession>
    <name>A0A0D2SW76_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G068100</name>
        <name evidence="6" type="ORF">Gorai_009031</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SW76"/>
    <dbReference type="STRING" id="29730.A0A0D2SW76"/>
    <dbReference type="Gramene" id="KJB48413">
        <property type="protein sequence ID" value="KJB48413"/>
        <property type="gene ID" value="B456_008G068100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB48414">
        <property type="protein sequence ID" value="KJB48414"/>
        <property type="gene ID" value="B456_008G068100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763284"/>
    <dbReference type="eggNOG" id="ENOG502QTXA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPNMTRD"/>
    <dbReference type="OrthoDB" id="1890360at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="PFYRE" evidence="3">
        <location>
            <begin position="442"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="536"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="350"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="LXXLL motif" evidence="3">
        <location>
            <begin position="450"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB48414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0592044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="614" mass="67688" checksum="B63B6579EBB9AB70" modified="2015-04-29" version="1">MAYMCADSGNLMAIAQQVIKQQQQQEQQQEQHHHQQQQLLGVSHVTLNPWPNNPHHGVSNSPILGYGLSGPGFTDLFQGDTGEGFQFPNMGHHHSSGFRFPDFGGGSGGEFDTDEWMDCLMNSGDSTDSSNLPSGCEVWQNNADFGLYGADPFSACPNRLSVACPTPSDLNRVIFPTEAQKNLSPTLQPQHQLPTWSPSPSPPPPPPPHVAVKETKASSPPSQTPLTNDATGVSADSTKIESAPPLLKALLDCARLSDSEPERAIKSLVELRESVSERGDPTERVAFYFTQALYSRVSLPAEKRLNLLETTSEDFTLSYKVLNDACPYSKFAHLTANQAILEATERATKIHIVDFGIVQGVQWAALLQALAARSAGKPTRIRISGIPAPVLGSSPAPSLYATGNRLRDFAKLLDLNFEFEPILTPIKELKESCFRVDNDEVLAVNFMLQLYNLLDATPVTVEAALCLAKSLNPKIVTLGEYEASLNRVGFVNRFKNALRYYTAVFESLEPNLPRDSPERVEVERQLLGGKIGAIIGAEEAEKRRERMEDKEQWKVLMESAGFETVSLSHYAISQAKILLWNYNYSSSYSLIESKPGFLTLAWKEVPLLTVSSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SYR6</accession>
    <name>A0A0D2SYR6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GH10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G020100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SYR6"/>
    <dbReference type="STRING" id="29730.A0A0D2SYR6"/>
    <dbReference type="Gramene" id="KJB47306">
        <property type="protein sequence ID" value="KJB47306"/>
        <property type="gene ID" value="B456_008G020100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB47307">
        <property type="protein sequence ID" value="KJB47307"/>
        <property type="gene ID" value="B456_008G020100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762769"/>
    <dbReference type="eggNOG" id="ENOG502QSCW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEWNSHH"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF82">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395581" description="GH10 domain-containing protein" evidence="6">
        <location>
            <begin position="28"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="7">
        <location>
            <begin position="216"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB47306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="579" mass="64894" checksum="7F45C851CF858974" modified="2015-04-29" version="1">MELWQKESVLLFLPLSILLSGLVKVDALSYDYTASIECLAQPHKAQYGGGMIKNPELNEGLIGWSTFGNAVIEHRNESDGNKFVVAGKRNHFQDSVSQKLFLENGKLYTFSAWVQVSEEKALVRAVFRTVTGLKRAAETVAESKCWSMLKGGLTVDASGPAELFFETDNTSVEVWVDSVSLQPFTQEEWMSHHVESIEKTKRRVRIRVEAEGNPVVNSKISIHQKASGKPIGCAVNKGILDNVGYQNWFTSRFTHTTFENEMKWYTTEPVRGKEDYSLPDSIMTLMKQHNIAVRGHNIFWDDPHYQPNWVPSLQPNDLSAAANKRINSIMTKYKGQVIGWDVVNENLHSNFFESKLGPDASATFYKMAAGIDHSIPLFMNEFNTLEQKGDAASTPAKYLEKLKNIQTFMGAEAKRMAIGLECHFDVPSLPYIRSSLDTLAATNLPIWLTEIDVQSGSNQAMYLEQVLREGHSHPGVSGMIIWSAWNPNGCYRMCLTDNNFKNLATGDVVDKLLKEWGIKATVEGKTDAAGFFEASLFHGEYEVKISDPVEAANSSVSQRFKVEPRHDSQDQIMLLQVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1H5</accession>
    <name>A0A0D2T1H5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G0646001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
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                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Lin L."/>
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                <person name="Wang Z."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">8</strain>
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    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="2">Belongs to the SAP30 family.</text>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T538"/>
    <dbReference type="STRING" id="29730.A0A0D2T538"/>
    <dbReference type="Gramene" id="KJB51639">
        <property type="protein sequence ID" value="KJB51639"/>
        <property type="gene ID" value="B456_008G226300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUFW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FQTADLM"/>
    <dbReference type="OrthoDB" id="1926382at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11449">
        <property type="entry name" value="bHLH_AtAIB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000078">
        <property type="entry name" value="Transcription factor bHLH13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045084">
        <property type="entry name" value="AIB/MYC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="MYC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11514:SF43">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="9">
        <location>
            <begin position="469"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="441"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="515"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="288"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB51639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0593269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="646" mass="70932" checksum="C628D01809CA7B14" modified="2015-04-29" version="1">MTDYRFASTMNLWTDDNASVMEAFMSSDLSALWQPPPQSSASTSTPAVVASSAAAAASGAPDLLKSSVAPQSHPSVALFNQETLQQRLQALIEGAHECWTYAIFWQSSYDYSGPAVLGWGDGYYKGEEDKGKRKLKTSSAVAEQEHRKKVLRELNSLISGSTAPTDDAVDEEVTDTEWFFLVSMTQSFVNGGGLPGQALFNSTPVWVVGSERLASSTCERVRQGQVFGLQTMVCIPSANGVVELGSTELITQSSGLMNKVRVLFNFNNGIEAGYLSMCNNIADEGENDPSSLWISDPNSGVEYKESHNNNQNQQIEKSIQFHDNPSSSSLTENPSSIQQRQSQNFGLNFSDYGFDGSYSVRNGNSSHLFKPESEETLNFGESKRSGNVVEENKKKTSPTSRGSHEDGMLSFSSAVVLPSSGMMKSSGGAGDSDNSDIEASVVKEAECVKPLEPEKKPRKRGRKPANGREEPLNHVEAERQRREKLNQRFYALRAVVPNVSKMDKASLLGDAISYINELSTKVQDAESEKQELQKQLEAMKKELAKKDSSPQNPKTSNHLGNRLIELETEVKVIGWDAMIRIQCKRKNHPAARLMAALKELNLDVQHASVTVVNDLMIQQATVKMGNPFYTQEQLRLALISKIGSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TFM7</accession>
    <name>A0A0D2TFM7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G078200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Activates SnRK1.1/KIN10 and SnRK1.2/KIN11 by phosphorylation of their activation-loop 'Thr-198' and 'Thr-176', respectively. Required for the regulation by SnRK1 kinases of the transcription of a large set of genes, the modification the activity of metabolic enzymes, and the control of various nutrient-responsive cellular developmental processes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Associates with the SNF1-related protein kinase (SnRK) complex. Interacts with AL1, a geminivirus (TGMV) protein essential for viral replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TFM7"/>
    <dbReference type="STRING" id="29730.A0A0D2TFM7"/>
    <dbReference type="Gramene" id="KJB55474">
        <property type="protein sequence ID" value="KJB55474"/>
        <property type="gene ID" value="B456_009G078200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770041"/>
    <dbReference type="eggNOG" id="KOG0585">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009615">
        <property type="term" value="P:response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000747">
        <property type="entry name" value="Serine/threonine-protein kinase GRIK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000206">
        <property type="entry name" value="Serine/threonine-protein kinase Ssp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF39">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GRIK1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="119"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB55474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="416" mass="47007" checksum="EB217EDB5A007461" modified="2015-04-29" version="1">MFSNSFSFARAMGCFGCFGFSTKPKQTTRPNCRSNFPLSQEFLLDEEIEEDDDDCSYNGEVTRTAHGDEVDSLGRGKRSEEILRFKLNNGLVCRQVPVKETNMIVRTEDENGNKMINEYVREYKIGSGSYGKVVLYRNSVDGKHYAIKAFHKSHLLKLRVAPSETAMTDVLREVLIMKILEHPNIVNLIEVIDDPTMDQFYMVLEYVEGKWVCEDSGPPRGLGEDTARKYVRDIVSGLMYLHAHNIVHGDIKPDNLLITSMGTVKIGDFSVSQVFEDDNDELRRSPGTPVFTAPECCVGLTYQGKAADTWALGVTLYCMILGRYPFLGETLQDTYDKIVNNPLILPSDMNPELRNLLEGLLCKDPKQRMTLNALAEHSWVIGEDGPIPQYLCWCTRNSYSREESNGRTGTQLTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TG20</accession>
    <name>A0A0D2TG20_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA double-strand break repair Rad50 ATPase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G083600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TG20"/>
    <dbReference type="STRING" id="29730.A0A0D2TG20"/>
    <dbReference type="Gramene" id="KJB55584">
        <property type="protein sequence ID" value="KJB55584"/>
        <property type="gene ID" value="B456_009G083600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769537"/>
    <dbReference type="eggNOG" id="ENOG502QXJW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VSQEWGQ"/>
    <dbReference type="OrthoDB" id="691984at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043424">
        <property type="entry name" value="BLT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071">
        <property type="entry name" value="GB|AAF24581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31071:SF16">
        <property type="entry name" value="MYB-LIKE PROTEIN Z ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB55584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="628" mass="70904" checksum="B2E0EEE8E225E18D" modified="2015-04-29" version="1">MSWQPHQNVEGKGKRVCKIRKRGCSSSSSSSLIQKYRFKRAILVQKRAGSTTPVPTWITATTKSPSLAIPSVEFPSKGSPKNVSKTKEGSVSARKLAATLWESNKIPSPQAMEDLEKKDRRRKPPIVAKMPHSLPPSLSDPSYTPISEKMDRPRIKAHKRRSSVVSPKLQLTDLDSVGNASLMEIEAHSRGNDHDGCITGIGTRLKDVRNSLATSKELLKVLNHVCGLEERNSSSMSLISALRVELDRARVEVDQLIRERRSNFDETEYLMRCFAEEKAAWKRKERERIRDAIACVAEELEVEKKLRRQTERLNKKLGKELADTNASLSKATKELKSEKRAKEILEQVCDELAKGMGEDRATAEELKRETAKVREEVEKEREMLHFADVLREERVQMKLSEAKHHFEEKNAVVEKLRNELETYLGTKIDGENGNGSPNLQRIKELEAYLKNINFGNCQAAKKDVDKGEVMVNGEECEADDSADSDLHSIELNMDNNDKSYNWSYASGNRVEGESKRIPTIRKENKGTKSRSEKLSWGSICLERGSSDSADWDYEDEIKRYKSVKSLRDHILSSNKIAPIGGFSSPTRQWSQSMHFQEPCSNGLPVLKVDDLKQPKVVSTRGEGRTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGV8</accession>
    <name>A0A0D2TGV8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">COBRA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G176300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the COBRA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGV8"/>
    <dbReference type="STRING" id="29730.A0A0D2TGV8"/>
    <dbReference type="Gramene" id="KJB42950">
        <property type="protein sequence ID" value="KJB42950"/>
        <property type="gene ID" value="B456_007G176300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTGW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TINHTAM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010215">
        <property type="term" value="P:cellulose microfibril organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052324">
        <property type="term" value="P:plant-type cell wall cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056900">
        <property type="entry name" value="COB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006918">
        <property type="entry name" value="COBRA_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673:SF36">
        <property type="entry name" value="COBRA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31673">
        <property type="entry name" value="PROTEIN COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25079">
        <property type="entry name" value="COB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04833">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038122">
        <property type="entry name" value="COBRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252540" description="COBRA-like protein" evidence="9">
        <location>
            <begin position="37"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="COBRA C-terminal" evidence="10">
        <location>
            <begin position="232"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="450" mass="50279" checksum="A866B00E736BDFAE" modified="2015-04-29" version="1">MANLLLFITRSFFKLCSFSLLILFLISCSSFPSTEAYDPLDPNGNITIKWDIMSWTSDGYVAVVTIYNFQQYRHIQAPGWKLGWTWAKKEVIWSMMGGETTEQGDCSRFKGNIPHCCNKHPTVVDLLPGTPYNQQIANCCKGGVLNSWAQDPATAASSFQLSVGQSGTTNKTVRVPVNFTLKAPGPGYTCGPAKIVKPSRFVTPDGRRETQAMMTWNVACTYSQFLAQEAPSCCVSFSSFCNDTIVPCSKCACGCQNTSQPGSCVESKASHIAPFVNSYTPLVRCTSHMCPVRVHWHIKLNYKEYWRVKITITNFNYNMNYTQWNLVVQHPNFDNLTQSFSFNYKSITPYTAINDTAMLWGIKFYNDMLLEAGPLGNVQSELLFRKDKATFTFEEGWAFPRRIYFNGDNCVMPTPNVYPGLPNASSHQLTSALGLLVTLLAAMALLFGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TH41</accession>
    <name>A0A0D2TH41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G2925002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TH41"/>
    <dbReference type="STRING" id="29730.A0A0D2TH41"/>
    <dbReference type="Gramene" id="KJB43004">
        <property type="protein sequence ID" value="KJB43004"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43005">
        <property type="protein sequence ID" value="KJB43005"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43006">
        <property type="protein sequence ID" value="KJB43006"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43007">
        <property type="protein sequence ID" value="KJB43007"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43008">
        <property type="protein sequence ID" value="KJB43008"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB43009">
        <property type="protein sequence ID" value="KJB43009"/>
        <property type="gene ID" value="B456_007G2925002"/>
    </dbReference>
    <dbReference type="OMA" id="ACISWGF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF56">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="50"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB43005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="135" mass="14452" checksum="F3C759A49E5A59B2" modified="2015-04-29" version="1" fragment="single">MEQQRKEATERLLSTQGHNNLFYSEENDGVCVGDGGLVAVSNFTSILGLSIFMAACITFGFGCAIGYSSPTQSSIMEDLGLSVTEFSLFGSILSIGSLIGAAISGKITDLFGRKLTMWILNLFYIGGWLAIAFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TH54</accession>
    <name>A0A0D2TH54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-haem dioxygenase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G011100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TH54"/>
    <dbReference type="Gramene" id="KJB53911">
        <property type="protein sequence ID" value="KJB53911"/>
        <property type="gene ID" value="B456_009G011100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="9"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB53911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="228" mass="26135" checksum="7D294FB95322EDE1" modified="2015-04-29" version="1" fragment="single">MSSDSHFGIPIIELPTNSKDLDGGSDEWRSLCKSVREACENHGCFQVVYHKISSHLQHELFSLIRQPFNLPLETKKQNVKSKPLHGYYEPGGDFLPFYESFGLEDASSCNSSKASPNLMQIHHHNHFYYQLRRVMKYSAPPSGEYTKVVSAHTDKLCSALLCEDGISGLEIETKDGEWENEYRYSLGTFAVPVKGTIIKAAKEMVDEEHPRFFQGYRFHGLRRLRKCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TIL5</accession>
    <name>A0A0D2TIL5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box protein At3g26010-like beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G204100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TIL5"/>
    <dbReference type="STRING" id="29730.A0A0D2TIL5"/>
    <dbReference type="Gramene" id="KJB43515">
        <property type="protein sequence ID" value="KJB43515"/>
        <property type="gene ID" value="B456_007G204100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RQDC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055290">
        <property type="entry name" value="At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056592">
        <property type="entry name" value="Beta-prop_At3g26010-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546:SF25">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35546">
        <property type="entry name" value="F-BOX PROTEIN INTERACTION DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24750">
        <property type="entry name" value="b-prop_At3g26010-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box protein At3g26010-like beta-propeller" evidence="1">
        <location>
            <begin position="156"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="416" mass="47058" checksum="2AD5E8CC746A955F" modified="2015-04-29" version="1">MFSFLVFMADFEGNNRETLEDDFCLLEDSDLEGDVDERFYELPILSPKAKAKIPVDYNKALKYVDRKEAGLEDVLRDHALHLLPAKTLFRFKTVSRRWDHWISSPLFAHRQTTYFKNVSGLFCQVADHSPSFISFNQDAYGMPDPSLSFFPEPVKVRSSCNGLVCCQGIEDDTYYICSPVTKEWKKLPRPNLYHGAKAAVVLAFEPYVLNFNESYELVCAVTFPDYPVVYFEIYSSRSSSWRVSDTICYELDGSGLHDGGYYMKGVVYWESSSGVILAFGLRDEQCGFLPLPANDEEYGNGALAMKHGELCYIQPRYQDNVCTINIHGNMDMSLKSVINLPYDAGSAFGVCRVLGFINGDILILGLGTRVVSYHVKEQKVELISQHEGGACTRYIPYVNSLVSLRHPLIRDKGLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJ28</accession>
    <name>A0A0D2TJ28_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G037700</name>
        <name evidence="6" type="ORF">Gorai_011038</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJ28"/>
    <dbReference type="STRING" id="29730.A0A0D2TJ28"/>
    <dbReference type="Gramene" id="KJB54526">
        <property type="protein sequence ID" value="KJB54526"/>
        <property type="gene ID" value="B456_009G037700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0KJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WRSKSTH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003676">
        <property type="entry name" value="SAUR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374">
        <property type="entry name" value="AUXIN-INDUCED PROTEIN-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31374:SF432">
        <property type="entry name" value="SAUR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02519">
        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0341">Growth regulation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB54526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0594119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="163" mass="18426" checksum="D8F33A77105A9154" modified="2015-04-29" version="1">MDHGNKSTGIKQIVRLKGMLQKWQTATFRSRPNSHNSQRNHGHGGVSRSINKVQTEKMYCDSDEDGCYSPEPAPDVPKGYFAVYVGPELRRFIIPTSYLSHPVFKILLQQAEEEFGYDHNGALTLPCEIETFKYLLKYIDQNQPKSHNVGGGSPVSEHVLICF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TK88</accession>
    <name>A0A0D2TK88_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G075600</name>
        <name evidence="10" type="ORF">Gorai_004332</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSP2"/>
    <dbReference type="STRING" id="29730.A0A0D2TSP2"/>
    <dbReference type="Gramene" id="KJB58156">
        <property type="protein sequence ID" value="KJB58156"/>
        <property type="gene ID" value="B456_009G196800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769075"/>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEKRVFW"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000195">
        <property type="entry name" value="Putative TPR repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000173">
        <property type="entry name" value="uncharacterized TPR repeat-containing protein At1g05150-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000287">
        <property type="entry name" value="uncharacterized TPR repeat-containing protein At1g05150-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45081">
        <property type="entry name" value="EF HAND FAMILY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45081:SF1">
        <property type="entry name" value="EF HAND FAMILY PROTEIN, PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="6"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="375"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="409"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB58156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="798" mass="89755" checksum="0D579BCCFC2E65C8" modified="2015-04-29" version="1">MATRGSRSEKVKRIFQQFDTNRDGGLNRDEMAALVVAVNPRVKFSDEQINAILDEVFRTYGEFIDGEKGLTYDGLLRTYDDGAGDVDRDFDALGLELNFDENKGASIVSEASSSSIADERVIESQKNQRTAAWAVSPHHGIVFDDTWKLVDDLEILLKRLKAKQAKDAKFRNDNFDAYSDAGWSRELGASAELSEKRVYWEESGPDYALFVKELGALRSRADGARSREEAFDGHMAIGRVLYEHQLFKEALICFKRSCELQPMDVRPHFRAGNCLYVLGKSKEAKEEFLLALESAEAGGNQWGYLLPQIYVNLGIALEGEGMVLSACEYYREAAILCPTHYRALKLLGSALFGVGEYRAAVKALEEAIFMKPDYADAHCDLASALHGMGEDERAIEVFQKAIDLKPGHVDALYNLGGLYMDLGRFQRASEMYTRVLAVWPNHWRAQLNKAVSLLGAGETEEAKKALKEALKMTNRVELHDAIYHLKQLQKKKVKTNGGTNGEAAFVIMDPSKFKTLGEKTTLRQDLGNALQIRAFQRLTRLNRCEVDLLKKEMNETDVPVSYSGSGGPQKSIRKPNLEEVLRKLLNFLKPETFQGAVKAINEKILSVLDETGSGRVDLGMFYAVLAPLCSGPPDKRKRIAFDALLWRPVNEGGSHIRKVDAVQYIKLLRAIFIPSHGASEMLEVHGETDTSMVSFNEFLIMFNDPDWGFGILSTLLKLETGDRNRHERHVCSVCRYPIIGSRFKEVKSHFSLCNQCYSEGKVPPNFKQDEYKFKEYGKEAEAMKDKCLCFNLQSRKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TUY3</accession>
    <name>A0A0D2TUY3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G309700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TUY3"/>
    <dbReference type="Gramene" id="KJB60519">
        <property type="protein sequence ID" value="KJB60519"/>
        <property type="gene ID" value="B456_009G309700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB60519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="85" mass="9504" checksum="B16BB6E6FE51E2B4" modified="2015-04-29" version="1">MTNLGVIDPPSIEFDPTHDQIIDPIGRNIGETQIKLEQPNIQTSSMKISIPTYKIKPILKPKPIKYVSTKRIPTILSVPPMVLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXZ4</accession>
    <name>A0A0D2TXZ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha,alpha-trehalose-phosphate synthase (UDP-forming)</fullName>
            <ecNumber evidence="3">2.4.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G362600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.15" evidence="3"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXZ4"/>
    <dbReference type="STRING" id="29730.A0A0D2TXZ4"/>
    <dbReference type="Gramene" id="KJB61504">
        <property type="protein sequence ID" value="KJB61504"/>
        <property type="gene ID" value="B456_009G362600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000100">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000046">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000039">
        <property type="entry name" value="alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012766">
        <property type="entry name" value="Trehalose_OtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011071">
        <property type="entry name" value="PRK14501.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02400">
        <property type="entry name" value="trehalose_OtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF130">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="791"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB61504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="915" mass="103011" checksum="79483290A49DB45C" modified="2015-04-29" version="1">MPGNKYNGNSNHIPTRVERLLRERVLSEQRKSIRASQSNEYLEEAGAARPFGQRLLVVANRLPVSAVRRGEDSWSLDISAGGLVSALLGVKQFEARWIGWAGVNVPDEIGQKALTKALAEKRCIPVFLDEEIVHQYYNGYCNNILWPLFHYLGLPQEDRLATTRSFQSQFAAYKKANQMFADVVNAHYEEGDVVWCHDYHLMYLPECLKKYNTKMKVGWFLHTPFPSSEIHRTLPSRYELLRSVLAADLVGFHTYDYARHFVSACTRILGLEGTPEGVEDQGKLTRVAAFPIGIDSDRFIRALELPQVQEHIKELKERFSGRKVMLGVDRLDMIKGIPQKLLAFEKFLEENPYWRDKVVLLQIAVPTRTDVPEYQKLTSQVHEIVGRINGRFGTLTAVPIHHLDCSLDFHALCALYAVTDVALVTSLRDGMNLVSYEFVACQEAKKGVLVLSEFAGAAQSLGAGAVLVNPWNITEVAASIGQALNMPAEEREKRHCHNFHHVTEHTAQEWAETFVSELNDTVVEAQLRSSKVPPELPQNDAMECYLLSSNRLVILGFNTTLTEPVDTPGSRGDQIKEMELKLHPALREPLTALCNDPKTTIVVLSGSDRCVLDKNFGEYNLWLAAENGMFLRHTKGDWMTTMPEHLNLEWIDSVKHVFEYFTERTPRSHFDFRDTSLVWNYKYADIEFGRLQARDMLQHLWTGPISNASVDVVQGSRSVEVRAVGVTKGAAIDRILGEIVHTTSMTTPIDYVLCIGHFLGKDEDVYTFFEPELPFDALSIARSKPFDGPRLLPAERSPPLKLPASKSGAKSSLHKMTQPPFPAPDRRTSSYYSGESLRRHPSVPEKISWSVLDLKGDNYFSCAVGRTRTSARYLLGSSDDVVSFLNRLTNASSSSDLVFGTDSLHLHPTHIRTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZS0</accession>
    <name>A0A0D2TZS0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase MuDR plant domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G119400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TZS0"/>
    <dbReference type="STRING" id="29730.A0A0D2TZS0"/>
    <dbReference type="Gramene" id="KJB80878">
        <property type="protein sequence ID" value="KJB80878"/>
        <property type="gene ID" value="B456_013G119400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RRK3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FTIRINC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF187">
        <property type="entry name" value="MUTATOR TRANSPOSASE MUDRA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB80878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="46200" checksum="5707EAFD48C2AF96" modified="2015-04-29" version="1" fragment="single">RSKFPTYNPNSTSPHFCIGMLFKDGEKFKSAIRKYSMCRRKEIKIIKTEPNRVRVKYIASKNFHDEHNSCVSFKNKMVNVKVIVEHFEATIGDNPKMKLREIQRRVASEMHVNKMVKDKLARNFVQEFAMLWDYANELKLKNPGSTIKMAVNRATLESPTHFKRFYVCFEALAKGWKEGCRPILGLDGCFLKGLFKGELLAAVERDGNNQILLTTDLGMEDGFGYTITSDQKRTKAFKGLHSLSDIVDNNLYETFNSSIVESRFKSIITMLEEIRVNMMTRIVAKRKQCSSWKYNYGPLIKKKFDDSKKEDADWKMIRNGENGCEISCPHACCTIWHFEQGPDDYLHRYYHKDTYLKAYEYTLQPIYGSHEWTKSGIKPVLPPVEKIMSGRPKKEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0P6</accession>
    <name>A0A0D2U0P6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectin acetylesterase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_013G131600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 6">Hydrolyzes acetyl esters in homogalacturonan regions of pectin. In type I primary cell wall, galacturonic acid residues of pectin can be acetylated at the O-2 and O-3 positions. Decreasing the degree of acetylation of pectin gels in vitro alters their physical properties.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
            <location evidence="2 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the pectinacetylesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0P6"/>
    <dbReference type="STRING" id="29730.A0A0D2U0P6"/>
    <dbReference type="Gramene" id="KJB81153">
        <property type="protein sequence ID" value="KJB81153"/>
        <property type="gene ID" value="B456_013G131600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784257"/>
    <dbReference type="eggNOG" id="KOG4287">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFYNKTE"/>
    <dbReference type="OrthoDB" id="2015280at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009505">
        <property type="term" value="C:plant-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052793">
        <property type="term" value="F:pectin acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004963">
        <property type="entry name" value="PAE/NOTUM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562">
        <property type="entry name" value="NOTUM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21562:SF5">
        <property type="entry name" value="PECTIN ACETYLESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03283">
        <property type="entry name" value="PAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008809677" description="Pectin acetylesterase" evidence="6">
        <location>
            <begin position="22"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB81153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="413" mass="46237" checksum="42A6C3C73DF56E59" modified="2015-04-29" version="1">MMKLSWVWIVIAIAFLQLVTGFLDFNETELSLIEAYDYGVSKLNYNPLMVGLTFITSAGAKGAVCLDGTLPGYHWHRGYGSGANSWLIQLEGGGWCNNVRTCVYRKKTRRGSSTYMEKQIPFTGILSDKAEQNPDFFNWNRVKLRYCDGASFTGDTENKAAKLQFRGQRIWLAAMEDLMSKGMRNAKQALLSGCSAGGLASILHCDEFRNMFPRTSKVKCLSDAGLFLDAVDVSGGRTLRSLYNGVVGLQGVQHNLPRICTIHSDPTSCFFPQNLISNIRTPLFILNAAYDSWQIQSSIAPPSADPHGYWHECRLNHAKCSASQMRFLQGFRIEMLNAIKGFSQSRENGLFINSCFAHCQTERQDTWFAANSPEIRNKAIAIAVGDWYFDRAGVKIIDCPYPCDKSCHNLVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U0P9</accession>
    <name>A0A0D2U0P9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G423500</name>
        <name evidence="2" type="ORF">Gorai_013674</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0P9"/>
    <dbReference type="Gramene" id="KJB62569">
        <property type="protein sequence ID" value="KJB62569"/>
        <property type="gene ID" value="B456_009G423500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768201"/>
    <dbReference type="eggNOG" id="ENOG502S3ZQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECLVFNM"/>
    <dbReference type="OrthoDB" id="509052at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006476">
        <property type="entry name" value="CHP01589_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01589">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871:SF59">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871">
        <property type="entry name" value="OS02G0137100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09713">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0596868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="96" mass="11489" checksum="DEA6D2231D8530C0" modified="2015-04-29" version="1">MNMDDSSASYIHMVHHLIEECLIFNMSKEECMEALAKHASIKPVITSTVWNELEKENKEFFEAYTRNRDQRATDMEKRQRIQFRVNAYMREKGNKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U411</accession>
    <name>A0A0D2U411_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_013G195000</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="4"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U411"/>
    <dbReference type="STRING" id="29730.A0A0D2U411"/>
    <dbReference type="Gramene" id="KJB82418">
        <property type="protein sequence ID" value="KJB82418"/>
        <property type="gene ID" value="B456_013G195000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03312">
        <property type="entry name" value="CIMS_N_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000003">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.210:FF:000018">
        <property type="entry name" value="5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003556">
        <property type="entry name" value="PRK05222.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30519">
        <property type="entry name" value="5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE N-terminal" evidence="16">
        <location>
            <begin position="3"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="15">
        <location>
            <begin position="432"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="15">
        <location>
            <begin position="670"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="605"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="675"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="677"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="690"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048690"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="PIRSR" id="PIRSR000382-3"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01717"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08267"/>
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        <source>
            <dbReference type="EMBL" id="KJB82418.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="793" mass="87923" checksum="47182DEF4E42E8F4" modified="2015-04-29" version="1">MASHIVGYPRMGPKRELKFALESFWDKKSSAEDLQKVAADLRSSIWKQMSDAGIKYIPSNTFSYYDQVLDATSMLGAVPPRYGWNGGEIGFDTYFSMARGNASVPAMEMTKWFDTNYHFIVPELGPDVNFSYASHKAVDEYKEAKALGVNTVPVLIGPVSYLLLSKPAKGVEKTFSLLSLLPKILPIYKEVISDLKAAGASWIQFDEPTLVLDLDSHKLQAFTAAYDDLESTLSGLNVLIETYFADLTSEAYKTLIGLKGVTAYGLDLVRGAQTLDLVKSNFPKGKYLFAGVVDGRNIWANDLAASFSTLKELEAVVGKENLVVSTSCSLLHTAVDLVNETKLDDEIKSWLAFAAQKVVEVNALAKALAGQKDEAFFSANAAAQASRKSSPRVTNEAVQKAAAALKGSDHRRATNVSARLDAQQKKLNLPILPTTTIGSFPQTLELRRVRREFKANKISEDDYIKAIKEEIKKVVDLQEELDIDVLVHGEPERNDMVEYFGEQLSGFAFTVNGWVQSYGSRCVKPPIIYGDVSRPKPMTVFWSSTAQSMTARPMKGMLTGPVTILNWSFVRNDQPRFETCYQIALAIKDEVEDLEKAGINVIQIDEAALREGLPLRKSEHAFYLKWAVHSFRITNCGVQDTTQVCILLHFFHVVKAFVSAHPLIGVVFIQQIHTHMCYSNFNDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTEEIADRINKMLAVLETNILWVNPDCGLKTRKYAEVKPALNNMVAAAKLLRTQLASAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U614</accession>
    <name>A0A0D2U614_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G164900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB63366"/>
        <property type="gene ID" value="B456_010G164900"/>
    </dbReference>
    <dbReference type="OMA" id="APVASWC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252366" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB63366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="73" mass="8444" checksum="C895E9A6280A37F8" modified="2015-04-29" version="1">MYLWVVLLRFSYSCLEWDFCYSLKARPSYCALAYQQVQPTVVQTVVAPVASWCRPQVVHFKCNVDTAFSEDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6Z2</accession>
    <name>A0A0D2U6Z2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G011200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB63681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="6354171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="protein indeterminate-domain 12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
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    <dbReference type="InterPro" id="IPR055185">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055186">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593:SF190">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10593">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22992">
        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22996">
        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB63681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="389" mass="41423" checksum="DFE6253CC58D4056" modified="2015-04-29" version="1">MAKFENSSSMAVSLIEAFQQTDGVQSKKKRNLPGMPDPEAEVISLSPKSLLATNRFICEICNKGFQRDQNLQLHRRGHNLPWKLRQRTDGNETRKKRVYVCPETSCVHHNAARALGDLTGIKKHYCRKHCEKKWRCERCSKTYAVKSDWTAHLKSCGTKEYKCNCGTVFSRRDSFYTHRAFCDALAEENARAQAATFSPPPLTQSTTTMVSPGLSTQSSEMLEIPMGLSPPDPPPPTTSISASNGDVLVTIFASTPPLETTSLSLSSPLYLSNNSSSSIFTAPSLQPAMSATALLQKAAQMGAAATSSPSLLRGLSFAVPSSSSTTPSTGHKPTSTLDLLGLGICGGGGGGRGGTSNGLSALFTQFGGGFNGEPAATTSYGAPNSSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDR8</accession>
    <name>A0A0D2UDR8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G167800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDR8"/>
    <dbReference type="Gramene" id="KJB66949">
        <property type="protein sequence ID" value="KJB66949"/>
        <property type="gene ID" value="B456_010G167800"/>
    </dbReference>
    <dbReference type="OMA" id="EETSQFK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36063">
        <property type="entry name" value="ARABIDOPSIS THALIANA GENOMIC DNA, CHROMOSOME 5, P1 CLONE:MOK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36063:SF8">
        <property type="entry name" value="GENOME ASSEMBLY, CHROMOSOME: A06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="72" mass="8349" checksum="7AFECCF83A80912F" modified="2015-04-29" version="1">MKGVKHLESSCEKAPSLFISHNKPSTSPSLETIFEETSQFKFEVEQHNTLFFLLFPFSLSFLSYLLLYTHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHP5</accession>
    <name>A0A0D2UHP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Multiple inositol polyphosphate phosphatase 1</fullName>
            <ecNumber evidence="4">3.1.3.62</ecNumber>
            <ecNumber evidence="3">3.1.3.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2,3-bisphosphoglycerate 3-phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_010G195300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2R)-2,3-bisphosphoglycerate + H2O = (2R)-2-phosphoglycerate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27381"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58248"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="3.1.3.80"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:27382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,5,6-tetrakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77115"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:77116"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1D-myo-inositol 1,2,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,6-trisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77119"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:195535"/>
            <dbReference type="ChEBI" id="CHEBI:195537"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:77120"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16989"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57798"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="EC" id="3.1.3.62"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:16990"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histidine acid phosphatase family. MINPP1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.62" evidence="4"/>
    <dbReference type="EC" id="3.1.3.80" evidence="3"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHP5"/>
    <dbReference type="STRING" id="29730.A0A0D2UHP5"/>
    <dbReference type="Gramene" id="KJB67526">
        <property type="protein sequence ID" value="KJB67526"/>
        <property type="gene ID" value="B456_010G195300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB67527">
        <property type="protein sequence ID" value="KJB67527"/>
        <property type="gene ID" value="B456_010G195300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773694"/>
    <dbReference type="eggNOG" id="KOG1382">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANSPWFA"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034417">
        <property type="term" value="F:bisphosphoglycerate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052745">
        <property type="term" value="F:inositol phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000017">
        <property type="entry name" value="Histidine acid phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016274">
        <property type="entry name" value="Histidine_acid_Pase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF8">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000894">
        <property type="entry name" value="Acid_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395500" description="Multiple inositol polyphosphate phosphatase 1" evidence="17">
        <location>
            <begin position="20"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="55"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="427"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00043691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB67526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="494" mass="56206" checksum="BA69171BFFC77A42" modified="2015-04-29" version="1">MAMAAILLLFLTLFSNSKADRDFDVRQHLCTVTRYGAVKDIVDNSFIPSDIPQGCTPIHLNLVARHGTRSPTKKRVREMEKLASHIKELIEDAKQRNLSLQKVPAWFHNWESPWKGKLKGGELDIKGEEELYQLGIRVRERFPDIFNEEYHPDVYPIKTTQIPRASASAVAFGMGLFSGKGSLGPGRHRAFAVTSESRASDTILRFFECCQTYKDFRKNQEPSFNKLKEPILTEITSALAKRYEFNFTRQDISSLWFLCKQESSLLDITDQACSLFSPTEVALLEWTDDIQMFMVKGYGKSLNYRMGVPLLKDVLQSMSEAINADEDNQVPGSYEKARLRFAHAETVVPFSCLLGLFLEGSDFERIQKEEPLDLPPKPPQKRNWRGSIVAPFAGNNMLVLYSCPANSSSKYFVQVLHNEHPIPMPGCGSTDFCPFQVFKDKIVEPHFMHDYDTLCNAHLDESKHKPETSKLSQLFHWIFRLGGNDDTPSHGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJW2</accession>
    <name>A0A0D2UJW2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G107700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJW2"/>
    <dbReference type="STRING" id="29730.A0A0D2UJW2"/>
    <dbReference type="Gramene" id="KJB56143">
        <property type="protein sequence ID" value="KJB56143"/>
        <property type="gene ID" value="B456_009G107700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56144">
        <property type="protein sequence ID" value="KJB56144"/>
        <property type="gene ID" value="B456_009G107700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56145">
        <property type="protein sequence ID" value="KJB56145"/>
        <property type="gene ID" value="B456_009G107700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768078"/>
    <dbReference type="eggNOG" id="KOG2073">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YILRECN"/>
    <dbReference type="OrthoDB" id="976155at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="610"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="730"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="794"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="637"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB56145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="842" mass="93930" checksum="30A7E66185378D4F" modified="2015-04-29" version="1">MFWQLTALSASSPVDSILDKENFTLEELLDEEEIIQECKALNSRLINFLRDRAQVEQLLQYIVEEPPEDADNKRSFKFPFIACEIFTCEIDVILRTLAEEEELMNLLFSFLEPNRPHSALLAGYFSKVVVCLMLRKTVPLMNYVQVHQDVFCQLVDLIGITSIMEVLVRLVAADDHVYPNFSDVMQWLADSNLLEMIVDKLSPSCAPEVHANAAETLCAITRNVPSALATKLSSPSFVARIFGHALEDSHSKSGLVNSLSVCISLLDPKRSAINSPLMYSFRNQLMYEPPIPVNSETINAMLPQLGDLLMLLNVSSDEKILPTTYGELRPPLGKHRLQIVEFIAVLLRTGNEAAQKELVNSGAIRRVLDLFFEYPYNNALHHHVESIMLSCLESKNDAIVDHLLQECDLIGKFLQTDKHQILSSDSNQPTLVAAGKRATRVGNIGHITRISNKLVQLGCSNSRIQACLQENSEWNEWQAKVLQERNAVENVYRWACGRPTSLQDRTRDSDEDDLHDRDYDVAALANNLSQAFRYRMHGNDDNEEQGALDRDDEDVYFDDESAEVVISSLRLGDEQGSLFTNSNWFAFQDDRTGNAPAATSPTEVMTEMNLNGTANGGNSSSDDEVVVGEEDELNENSQSVNSTSTSDVMNEFNNFMSRGDLSPQGEKANATQDMGFFRFETTENELFGDRSLPEWVRWGEYSDLQVGGSSKNPFLDDDSSDVNLPSQTETMVTDVAPPLNGSSDSMDLSEGSEGSDTNQKSPPLVPSLFEEDVEFVGVELEGTEKAMEQALKEGIVGEAGQLKRSSVPKVPEKENPDDDGAGMQEFNDSNYWRVDQEVSVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UPV9</accession>
    <name>A0A0D2UPV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G064800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UPV9"/>
    <dbReference type="STRING" id="29730.A0A0D2UPV9"/>
    <dbReference type="Gramene" id="KJB70241">
        <property type="protein sequence ID" value="KJB70241"/>
        <property type="gene ID" value="B456_011G064800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778037"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF3">
        <property type="entry name" value="OS09G0363800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="114"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="40056" checksum="FAC9BAA0FF89908E" modified="2015-04-29" version="1">MVAFSMVPFLGTVRSTPSLTSLAPYKRQISIRISPVSFPRNGFFPFRRFLQACLQSSSATMDTREKLPAEHSEIIFIGTGTSEGIPRVSCLTDPVKKCLVCSKAAEPGNINRRRNTSLLIRYGRPSGRCNILIDAGKFFYHSALQWFPEFGIRTIDAVIITHSHADAIGGLDDLRDWTNNVQPNISIYVAERDFEVMKKTHYYLVDTSVIIPGAAVSKLQFNIIQEEPFIVHDLQITPLPVWHGRGYRSLGFRFGDICYISDVSDIPEETYPLLENCEILILDALRPDRSSSTHFGLPRALEEVRKIKPKRTLFTGMMHLMDHEKVSEYLENLMETEGLDVQLSYDGLRIPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UX38</accession>
    <name>A0A0D2UX38_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 24 homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G235800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UX38"/>
    <dbReference type="STRING" id="29730.A0A0D2UX38"/>
    <dbReference type="Gramene" id="KJB73430">
        <property type="protein sequence ID" value="KJB73430"/>
        <property type="gene ID" value="B456_011G235800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73431">
        <property type="protein sequence ID" value="KJB73431"/>
        <property type="gene ID" value="B456_011G235800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777905"/>
    <dbReference type="eggNOG" id="KOG3229">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IMESMEP"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
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    </dbReference>
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        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB73431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25995" checksum="F76DEC8635BE1C7F" modified="2015-04-29" version="1">MDKFKNMLKPKPNPQQLLRDWQRKLRQECRNIERQIRDVQREEKGVQKAIREAAKRNDMGSAKALAKEIVMSRKAVNRLYENKAQLNSISMHLGESVAIARTVGHLSKSAEVMKLVNNLMKAPQMAATMQEFSKEMIKAGVIEEMVNDALDSALDSEDIEVETEEEVDKVLSEIAGETAAELPEAVRKERVRVSAHKESTSREEEAIVEGANDEEELEEIRARLARVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYU9</accession>
    <name>A0A0D2UYU9_GOSRA</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYU9"/>
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        <property type="gene ID" value="B456_009G362100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB61450">
        <property type="protein sequence ID" value="KJB61450"/>
        <property type="gene ID" value="B456_009G362100"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="987171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="3"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="258" mass="28121" checksum="DB10D4E3E4A3A5C5" modified="2015-04-29" version="1">MRHEEKEQEIPKLKDEHQMTKMELEEYKSKIGVMGNEIQQLKRKLEAQGQMLTSLEKLVEWFALQTNVQGSQVLATSGAVLQSVNELVSSGETGATYFQPSMAGFLQQTCFDQDYNITAPAAAAGFANHNLRFGFDAPNSQGNKAGDWTDSATANYNLPEYGATNNHDNIFNNVVGAGLLPTGSSLDANPEASFMFDAANNHENYGDLLPHGHATGSCSAHARKQFLAHVEKAKTTGWLDSSFHYGNSINGKENGACQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V6K4</accession>
    <name>A0A0D2V6K4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_010G065800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V6K4"/>
    <dbReference type="STRING" id="29730.A0A0D2V6K4"/>
    <dbReference type="Gramene" id="KJB64810">
        <property type="protein sequence ID" value="KJB64810"/>
        <property type="gene ID" value="B456_010G065800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774644"/>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010268">
        <property type="term" value="P:brassinosteroid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016131">
        <property type="term" value="P:brassinosteroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20639">
        <property type="entry name" value="CYP734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000029">
        <property type="entry name" value="Cytochrome P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050665">
        <property type="entry name" value="Cytochrome_P450_Monooxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282:SF224">
        <property type="entry name" value="CYTOCHROME P450 734A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24282">
        <property type="entry name" value="CYTOCHROME P450 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB64810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58689" checksum="0335EAB065AB3CE6" modified="2015-04-29" version="1">MEEVWQWLKLVGICLMLLMMVLKMVVLLWWRPRKIEEHFSRQGIRGPPYHFFIGNVKELVGMMLKASSQPMPFSHNILPRVLSFYHHWKKIYGATFIVWFGPTVRLTVSDPDIIREIFTSKSELYEKNEAHPLIKQLEGDGLLSLKGEKWAHHRKIISPTFHMENLKLLVPVVAQSVIEMVEKWSALIKRSKSGEIEIEVCEWFQSLTEDVITRTAFGSSYEDGKAIFGLQAQQMVLVAEAFQKVFIPGYRFLPTKRNISCWKLDRGIKKSLKKLIERRRSNCGNKMQGNGAKDLLGLLMEASNDISVNDIIEECKSFFFAGKQTTSNLLTWTAVLLAMHPQWQVQAREEVLRVCGLRDIPNKDDFVKLKTLSMILNESLRLYPPTVATIRRTKVDAELGGYMIPHGTELLIPILAVHHDKAIWGNDANEFNPARFSGGVARAAKHPIGFIPFGLGVRTCIGQNLAILQAKLALSIILQRFSFKLAPTYQHAPTVLMLLYPQYGAPIIFQPLSQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VEW6</accession>
    <name>A0A0D2VEW6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G168700</name>
        <name evidence="11" type="ORF">Gorai_003173</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0603013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VEW6"/>
    <dbReference type="STRING" id="29730.A0A0D2VEW6"/>
    <dbReference type="Gramene" id="KJB81951">
        <property type="protein sequence ID" value="KJB81951"/>
        <property type="gene ID" value="B456_013G168700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782619"/>
    <dbReference type="eggNOG" id="KOG0600">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07840">
        <property type="entry name" value="STKc_CDK9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000043">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000021">
        <property type="entry name" value="probable serine/threonine-protein kinase At1g54610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF387">
        <property type="entry name" value="F8L10.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="127"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="437"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="481"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB81951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0603013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="703" mass="78319" checksum="41807A4CA7503E15" modified="2015-04-29" version="1">MGCICCKPSAIEDSKQSPTSKVSLDVRVSMATSSRREDSQRTKDRYGNSEGRTMLIDKQVNGSVRIHGENLDRKREKVECVVRQHPGRGSVPKAIEGEQVAAGWPAWLAAVAGEAIQGWIPRRADSFEKLDKIGQGTYSNVYRARDLDQKKVVALKKVRFDNLEPESVRFMAREIHILRRLDHPNVIKLEGLVTSRMSCSLYLVFEYMEHDLAGLASNPGLKFSEPQVKCYMQQLLCGLDHCHSRGVLHRDIKGSNLLLDNNGILKIADFGLASFYDPLQNQPFTSRVVTLWYRPPELLLGATYYGTAVDLWSTGCILAELYAGKPIMPGRTEVEQLHKIFKLCGSPSEDYWRKSKLPHATIFKPQRPYRRCVAETFKEFPAPALALMETLLSIDPSDRGSAASALKSEFFTTKPLPCGPSSLPKYPPSKEFDAKMRNEEARRQGAAGTKGQRPELERKATRESRAAPAPDANAELVLSMQKRQNQSNSKSRSEKFNPHPEEIASGFPIDPPRPSQAVESNADAHGNHPKRGSHSGPLSHRAAWAKSGKNRDDPPKILTGADLSMMSGLVAARRNNLISEDHRESSGSSQSEAPKLFARFPGSFKEASESFIQHDQEHNVQQKEDGRSDNNDPVLLGYGSKGNKIHYSGPLLVPSGNVDQMLKDHDRQIQEAVRRARLDKAKKRKVQLEANHMSTTSLFVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFJ5</accession>
    <name>A0A0D2VFJ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G185900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFJ5"/>
    <dbReference type="Gramene" id="KJB82266">
        <property type="protein sequence ID" value="KJB82266"/>
        <property type="gene ID" value="B456_013G185900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82268">
        <property type="protein sequence ID" value="KJB82268"/>
        <property type="gene ID" value="B456_013G185900"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1925970at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044806">
        <property type="entry name" value="WVD2/WDL1-4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46372:SF6">
        <property type="entry name" value="PROTEIN WVD2-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46372">
        <property type="entry name" value="PROTEIN WVD2-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="8">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="179"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB82266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="345" mass="37705" checksum="E39FE948DD48B4DA" modified="2015-04-29" version="1">MGRELTDVDMDGKPNGVVNSNGNLTVSEGSESNNYEVKECTAKNSVVDNGHEKQEALGVKSTNFGTDIPEDQKCMDNDELSATASKPIGAGQAHHATSKTGANGTANVNSALSPATTKGSEPNSPITPLILRKPLQPYDRKHPDDEDNWSLTSSAASVRTARSRVTIGSAPTFRSAERAEKRREFYQKLEEKHRALEAERSQFEARTKEEQEAALKQLRKNMVVKANPVPDFYYEGPPRKVELKKLPLTRPKSPNFTRRKSCGDAVRSSQDEKAKACCQTHRRSLGNHTERSTTANEFKSKGRVSGQTSNGAGKAKERAKQVKEATKAAPTKIIEPSNANITVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGU3</accession>
    <name>A0A0D2VGU3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_013G215400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGU3"/>
    <dbReference type="Gramene" id="KJB82816">
        <property type="protein sequence ID" value="KJB82816"/>
        <property type="gene ID" value="B456_013G215400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782413"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVGENIN"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006857">
        <property type="term" value="P:oligopeptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01022">
        <property type="entry name" value="PTR2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB82816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="64067" checksum="51F4013C0CABE6DB" modified="2015-04-29" version="1">MDEKMSLTVADAVDYKGHPADKSRTGGWVPAALSLGIEICERLSTMGIAVNLVTYLGGTMHLPSATSANVVTDFMGTSFLLCLLGGFLADSYLGRYRTIAIFAMVQMLGTCLLAVSTKLPQLRPPPCKYTNVTQCEQANSFQMGILYLSLYLIALGTGGLKSSVSGFGTDQFDEKNEKEKAQMAYFFNRFFFVISTGTLMAVTVLVYIQDEVGRSWGYGICSASMFIALMIFFSGTKRYRYKKCSGSPIVHICQVVSAASGKKTAKLPSDISLLYEDLPEASRIHHTDQFRFLDKASVVTEDDYRQGSFMMNPWKLCPVTRVEEVKKMIRLLPIWATTIIFWTTYAQMITFSVEQATTMERTIGHFQIPAGSLTVFFVGAILISLAVYDRFIIPLCKKWRGEPGFTNLQLIGIGLFLSAMGMAAAAVVEVKRLSVAKKYNETTTLPITVFYLIPQFFLVGAGEGFIYTGQLDFFITQSPKGMKTMSTGLFLTTLSLGFFFSSLLVSIVKATTGSSDKQGWLGEHINKGRLDCFYGLLAALSFFNFGLFLLSAAWFRKKTVKQAPETEIIVKESTIEEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY07</accession>
    <name>A0A0D2VY07_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_012G110800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VY07"/>
    <dbReference type="STRING" id="29730.A0A0D2VY07"/>
    <dbReference type="Gramene" id="KJB76860">
        <property type="protein sequence ID" value="KJB76860"/>
        <property type="gene ID" value="B456_012G110800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780078"/>
    <dbReference type="eggNOG" id="ENOG502QQ4D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTWNEFQ"/>
    <dbReference type="OrthoDB" id="2015856at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11350:FF:000011">
        <property type="entry name" value="O-fucosyltransferase 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741:SF4">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31741">
        <property type="entry name" value="OS02G0726500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB76860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="633" mass="72454" checksum="08111E9BDA09F3AA" modified="2015-04-29" version="1">MSSGAANISANGSPMQGGPTTTRRRVADSPITAESDSNNPSSITDASNDEESDNPNGYILSVSSSVCGSHCLQQHHVMRHLQLRRKLLFSWVPDRWFIWIDNLCHWTVNMGHSLRSGRNMGRKILGLLLFMAVVSVFIKVSLFSTHVDVNGKWKKENGLLILQTFKEDWAMAQRVVSETEHSMPKRVLERISTPEIWMKPNSDNYHQCISRPKNQIRTRSKSNGYIIVHANGGLNQMRTGICDMVAVAKIMNATLVLPSLDHESFWTDPSDFKDIFDWRHFINVLKDDIDIVEYLPIKYSTIKPLVKAPVSWSKANYYRREVLPLLKRHKVIKFTHTDSRLANNNLPSSIQRLRCRANYEALRHAKEIEDLGRTLVDRLKSNNDPYIALHLRYEKDMLAFTGCIHNLTVEEGNELTVMRYNVRHWKEKEIDSEERRRQGGCPMTPREAAVFLKAMGYPSSTPIYIVAGEIYGSNSMAAFRSEFPNVYSHSTLATEEELELFKPYQNRLAALDYIVALESDVFVYTHDGNMAKAVQGHRRFEGFRKTINPDRQNFVKLIDQLDEGFITWEMFSSEVKSLHSDRLGAPYMRQTGESPRLEENFYANPLPGCICKTSQVQKISGPKFDQTLSSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2WA53</accession>
    <name>A0A0D2WA53_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peroxin-13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_N001500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxin-13 family.</text>
    </comment>
    <dbReference type="EMBL" id="KB204119">
        <property type="protein sequence ID" value="KJB84020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2WA53"/>
    <dbReference type="STRING" id="29730.A0A0D2WA53"/>
    <dbReference type="Gramene" id="KJB84020">
        <property type="protein sequence ID" value="KJB84020"/>
        <property type="gene ID" value="B456_N001500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSVT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMERMAF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035463">
        <property type="entry name" value="Pex13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19332:SF1">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB84020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="255" mass="27066" checksum="5187B264699D0B16" modified="2015-04-29" version="1">MTWGALELRDKSQSNPSTGESPPKPWEQVGGSSDSRTFKSPSIGSTNDVVEASGTARPGEIVSTTDRTTAVDRNVLGRPLPNRPWEQQTYGSTCGGRGYSSSLNYNSGYGSGMYGLSCDGLGSYGGGLYGNGMYRGGYGGLYENSGMYSGGMYGGGLGGFGQDSNNPFGAPPSPLGFWISFLRVLFDRTGVLYGEIARFVLRLLAIKTKPRKINQPGPGRVLGPHNHHGNQNYIDASKAAPSVAWDNIWGENISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M811</accession>
    <name>A0A0D2M811_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G076700</name>
        <name evidence="3" type="ORF">Gorai_022453</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dynein light chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M811"/>
    <dbReference type="SMR" id="A0A0D2M811"/>
    <dbReference type="STRING" id="29730.A0A0D2M811"/>
    <dbReference type="Gramene" id="KJB13467">
        <property type="protein sequence ID" value="KJB13467"/>
        <property type="gene ID" value="B456_002G076700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3430">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FIHFYIG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000008">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF70">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="1" id="KW-0243">Dynein</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB13467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0580224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="109" mass="11906" checksum="A2DFE61564BECF39" modified="2015-04-29" version="1">MLEGKAVVGETDMLQTMQQVALDVAAKALDFFDVTEATEIARFIKKEFDRAYGSGWQCIVGTDFGSFVTHCSGCFIYFCIGSLAILLFRGSAATEPDPHHFSALETLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MB90</accession>
    <name>A0A0D2MB90_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">30S ribosomal protein S31, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G149200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bTHX family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MB90"/>
    <dbReference type="STRING" id="29730.A0A0D2MB90"/>
    <dbReference type="Gramene" id="KJB14922">
        <property type="protein sequence ID" value="KJB14922"/>
        <property type="gene ID" value="B456_002G149200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785370"/>
    <dbReference type="eggNOG" id="ENOG502S834">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTRRIMM"/>
    <dbReference type="OrthoDB" id="911986at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032544">
        <property type="term" value="P:plastid translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030826">
        <property type="entry name" value="Ribosomal_bTHX/bTHXc/bTHXm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044695">
        <property type="entry name" value="Ribosomal_bTHXc/bTHXc_plant"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04560">
        <property type="entry name" value="ribo_THX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34550">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S31, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34550:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BTHXM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17067">
        <property type="entry name" value="RPS31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="10206" checksum="DE2A9378EBC5D612" modified="2015-04-29" version="1">MAMIQWCGTVARRVVMKQWPPLSSASPIEVMASPRAPTLCGRGDKKTKKGKRFKGSYGNARPKKEKKIERIKDKVEVPRSTPWPLPFKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ME44</accession>
    <name>A0A0D2ME44_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="9">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G212600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="9"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ME44"/>
    <dbReference type="STRING" id="29730.A0A0D2ME44"/>
    <dbReference type="Gramene" id="KJB16107">
        <property type="protein sequence ID" value="KJB16107"/>
        <property type="gene ID" value="B456_002G212600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786055"/>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009082">
        <property type="term" value="P:branched-chain amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000003">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000003">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF28">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB16107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="387" mass="43020" checksum="333498AE1E003020" modified="2015-04-29" version="1">MFMFSRSICCAKLNQLSTFETLFSNLKLRPCATPLIGPLQTCEYRIYSREKAEYANVNWDELGFALTKTDYMYVMNFTEEEQKFFNGTLTRFGNIEMCPSSGILNYGQGLFEGLKAYRKEDEGILLFRPQENALRMKMGADRMCMPSPTVDQFMDAVKKTVLANKRWVPPYGRGSLYVRPLLMATGRNLGVKPSSDYTFLVYASPVGNYHKGDLNLMVEDNVHRAIPGGTGGIKAVTNYSPVYKPLTEAKAKGFSDLLFLDALTGSNIEEGSACNIFILKGNVISTPTTHGTILPGITRKSIMEIASDFGYQVEERAIPIKEVFDAEEVFCTGTAMVVKSVASITYQGKRIGYKLGAETLAQKLHATLTGIQTGLIEDKLGWTMLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MKC2</accession>
    <name>A0A0D2MKC2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G069800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MKC2"/>
    <dbReference type="SMR" id="A0A0D2MKC2"/>
    <dbReference type="STRING" id="29730.A0A0D2MKC2"/>
    <dbReference type="Gramene" id="KJB18788">
        <property type="protein sequence ID" value="KJB18788"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18790">
        <property type="protein sequence ID" value="KJB18790"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18791">
        <property type="protein sequence ID" value="KJB18791"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18792">
        <property type="protein sequence ID" value="KJB18792"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18793">
        <property type="protein sequence ID" value="KJB18793"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18794">
        <property type="protein sequence ID" value="KJB18794"/>
        <property type="gene ID" value="B456_003G069800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788107"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="935493at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048767">
        <property type="term" value="P:root hair elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB18792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41712" checksum="2478DE523F80283D" modified="2015-04-29" version="1">MADAEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDSLMKILTERGYMFTTTAEREIVRDMKEKLAYVALDYEQELETAKSSSSVEKNYELPDGQVITIGAERFRCPEVLFQPSLIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKGEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MLD4</accession>
    <name>A0A0D2MLD4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G090200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MLD4"/>
    <dbReference type="STRING" id="29730.A0A0D2MLD4"/>
    <dbReference type="Gramene" id="KJB19232">
        <property type="protein sequence ID" value="KJB19232"/>
        <property type="gene ID" value="B456_003G090200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="5">
        <location>
            <begin position="166"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB19232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="320" mass="36437" checksum="EE485A580ABD4BDC" modified="2015-04-29" version="1">MIFFMNSINSDISAIDLCDEIPTIDYSLLFSENHDERAKSLEHLGKACQEFGFFYLINGVEQSVVEGALKGIFDFCELTNQEERSEYLKKNPMDRIRWGLRSHVGENREYLKIVAHPEYHCPSKPASFREYFKRMHEVELGLAKAISKILGYEETYIEKEFKLEVGFDVSAMNLYPPSFQSKCSIGVPEHTDPGFFVSLIQDVNGGLQMLTHKGNWVTVNIPRNAIFINLGDHLEILSNGKYKSHIHQVILDNNEVNRISMATLHGPSLDIFVAPALRFIDESHPPAYRGITYKESLELNGSDEIDVQSSLSLLRIPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N282</accession>
    <name>A0A0D2N282_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G222200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N282"/>
    <dbReference type="STRING" id="29730.A0A0D2N282"/>
    <dbReference type="Gramene" id="KJB26037">
        <property type="protein sequence ID" value="KJB26037"/>
        <property type="gene ID" value="B456_004G222200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792324"/>
    <dbReference type="eggNOG" id="KOG1082">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VFFTHEG"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10538">
        <property type="entry name" value="SET_SETDB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000046">
        <property type="entry name" value="SET-domain containing protein lysine methyltransferase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.850">
        <property type="entry name" value="Histone-lysine N methyltransferase , C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025776">
        <property type="entry name" value="SUVR4/1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043017">
        <property type="entry name" value="WIYLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018848">
        <property type="entry name" value="WIYLD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46450">
        <property type="entry name" value="INACTIVE HISTONE-LYSINE N-METHYLTRANSFERASE SUVR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46450:SF1">
        <property type="entry name" value="INACTIVE HISTONE-LYSINE N-METHYLTRANSFERASE SUVR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10440">
        <property type="entry name" value="WIYLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51580">
        <property type="entry name" value="SAM_MT43_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="630"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="391"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB26037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="795" mass="88435" checksum="01EA073EBD26925F" modified="2015-04-29" version="1">MAPNPRVVQAFRTMKEIGISEEKVKPVLKKLLKLYDKNWELIESENYRVLADAIFEEEDSKVSEPKKSTAHDQEDIDEEGSTPVELVRPLKRARLKNQEGLATCSHTNGSSNVAGTLLKEPKVEENEIPPASLQHRSLQSNVGNIRTEILPASPGPVCPQPPSHAPVSPHHSGRDKGKQIVEPRPNYKGKEPMSPHVASKGKGPERASVALRIKDPAPEPGIIPNNRVSATQALIIPKEEPFTDDMPQDEVPLAVIQPDSLSGRDLPIGDFSTEKSNWLEPPESLHAAEIAGSSASASGSERHTSCEHATVPDEIPSILEIASSQLGEVTISLSYNSALGGPNFQLPSIDELRGLMELRCLQSYKLIDPNFDVIKILTDMCECISELATNSSNQSQEGNEMPALDVLKKSPSRGDAEKNKENGCCEAAMMLNESFDNHCSGNGFVDNVGRKELVVAPQHHLTSNELRRVLDASDITKGEENFEISWVNEINKEFPTPFQYISDNLVFQNAHVSFSLSRIGDERCCPTCLGDCLFSQKPCVCACQAGGKFAYTPEGVIKEDFLEECISMTRDPQKQCLLNCTECPLERSKADDFPEPCKGHLQRKVIKECWIKCGCNKQCGNRVVQRGVNYKLQVFLTPDGKGWGLRTLENLPKGAFVCEFVGEILTIPEFYARNREKHTSPVLLDAYWGLKGVPKDEEALCLDATCYGNVARFINHRCLDANLIEIPVEVETPDLHYYHLAFFTTREVHALEELTWDYGIDFDDLDHHVKTFQCRCGSKFCRNMKRSIRSKSATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8A6</accession>
    <name>A0A0D2N8A6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G114400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8A6"/>
    <dbReference type="STRING" id="29730.A0A0D2N8A6"/>
    <dbReference type="Gramene" id="KJB08938">
        <property type="protein sequence ID" value="KJB08938"/>
        <property type="gene ID" value="B456_001G114400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS12">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMKAATN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000016">
        <property type="entry name" value="probable serine/threonine-protein kinase At4g35230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000069">
        <property type="entry name" value="probable serine/threonine-protein kinase At5g41260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045845">
        <property type="entry name" value="BSK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058209">
        <property type="entry name" value="TPR_BSK1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45863:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BSK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25575">
        <property type="entry name" value="TPR_BSK1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB08938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="40029" checksum="1B956F99E86E9FB9" modified="2015-04-29" version="1">MPNETLSKHLFHWENQHMKWAMRLRVALYLAQALDHCSSRGRALYHDLNAYRILFDQEGNPRLSSYGLMKNSRDGKSYSTNLAFTPPEYLRTGRVIPESVVYSFGTLLLDLLSGKHIPPSHALDLIRGKNFLMLMDSCLEGHFSNDDGTELVRLASRCLQYEPRERPNVKSLVTALTPIQKETEVPSHVLMGIPHGTLSSQQKILTPLGEACSRMDLTAIHEMLEKNGYKDDEGVANELSFQMWTDQIQETLNSKKRGDTAFRAKEFETAIECYTHFIGGMMVSPTVFARRCLCYMLFDMPQEAPGDAMQAQVISPEWPAAFYLQAAALFSLGMDKDALETLKDGTDLEARKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NA23</accession>
    <name>A0A0D2NA23_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G096000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KJB29347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2NA23"/>
    <dbReference type="Gramene" id="KJB29347">
        <property type="protein sequence ID" value="KJB29347"/>
        <property type="gene ID" value="B456_005G096000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052799">
        <property type="entry name" value="Rho_GAP_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46265:SF22">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN REN1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14389">
        <property type="entry name" value="Lzipper-MIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="53"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="220"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="620"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB29347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="738" mass="81380" checksum="411461C2912ECD26" modified="2015-04-29" version="1">MATKKNESSQKQQRMVFKKDEPSKRHQGDAAVVASPGPLPQAPPTPKSRVRNSVLKSGPLFLSTKACTHILPEKYTLRGIGWTSWKKRWFILTQTSLVFFKSDPSAIPQKENEVNLILGGIDLNNSGSVVVKADKKLLTVLFQDGQDGRTFTLKAESSEDLYEWKAAFENALSQAPSSPHVLGKNDILGNEKANAVNGSKDPVNNKQPVRSTVLGKPILLALEDVDGAPTFLEKALRFIEEHGTKAEGVLRLAADVEDVKCRIQEYEKGKTEFSPEEDPHVIADCIKYVIRELPSCPVPASCCNALLEAYRTLGGDRVNTMREAVLDAFPEPNRRLLQRILMMMRAVASNKTLNRMSSSAVAACMAPLILRPLVSGDCEIENDFNAGDDSSIQLLRAAAAANHAQAIVITLLEEYDKIFGEGYVPPNLYYGTEESGSESESESESESESESEEAADDDCNDATSGSNAYCDSDYVASGTGSKSGHSINNDLDDDKDSDYLSSSSEPSIADGDLKATKKLSSSLHSSLSENDLQRSEDNQSNKSSVIEANMFAEFGHRAKRPTVWGWAIAKKKLSMEPVHFPSKEEAEIERIKAEKSDLERGHTEEIEGNLVYGACLEKQKKTLHGHCQALQNDVSRLEEELHRERDKRTALEAGLTPSQGTVTLPNTVDEKIKADIKDIAQAEADINNLNKKVDELWMQLNQLLEQNSVSMNDRSNRHQPNHQEKRESGCSFLTGWIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NA65</accession>
    <name>A0A0D2NA65_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G098200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HD-ZIP homeobox family. Class II subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB29392">
        <property type="protein sequence ID" value="KJB29392"/>
        <property type="gene ID" value="B456_005G098200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797276"/>
    <dbReference type="eggNOG" id="KOG0483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000577">
        <property type="entry name" value="Homeobox-leucine zipper protein 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050762">
        <property type="entry name" value="HD-ZIP_Homeobox_LZ_Class_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003106">
        <property type="entry name" value="Leu_zip_homeo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714:SF24">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45714">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN HAT14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02183">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00340">
        <property type="entry name" value="HALZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="11">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="110"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB29392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="256" mass="28916" checksum="0CC8CA184E127484" modified="2015-04-29" version="1">MGFDDICNTALGLGLGCLVKQENISQLDHHQQKKKQLFLKHDHFSPSLLSLAPSYDTCAIFDAHQQQASSLSAASSFSNSSVKRERDLGGEEVELERICSRVSDEDDEGSPRKKLRLTREQSSILEDKFKQHSTLSPKQKQALAEELNLRPRQVEVWFQNRRARTKLKQTEVNCELLKKCYETLTEENKRLQKEVEELKSLKVTAPCYMQVGAATLTMCPSCERVDNVGENPSTTLFTLGQKSHFITPFTHPSAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NAA8</accession>
    <name>A0A0D2NAA8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G164100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NAA8"/>
    <dbReference type="STRING" id="29730.A0A0D2NAA8"/>
    <dbReference type="Gramene" id="KJB09773">
        <property type="protein sequence ID" value="KJB09773"/>
        <property type="gene ID" value="B456_001G164100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SYFZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KIHPNKA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.670">
        <property type="entry name" value="photosystem ii from thermosynechococcus elongatus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044900">
        <property type="entry name" value="PSII_PsbC_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB09773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34389" checksum="B6DEC048EBF003B4" modified="2015-04-29" version="1">MNEALVSDVTEEEIHAALLKIHPNKAPGPDGMTSKVDEFFEEIAQVNQMELRSGKKLPPVPNYGKNLVQELSQSKNRSSPNPESPVQDHGLSQNQNPGGIPIDRGAVGALSSQNEVTQRGRSRMLAGQTLAANGQHVRYDILAHLKKIPALLSVYDALKMSAELRMSLVYALTNPEEFSNEVNQVKMRSSEPTYAECLALITFTDDYLQPGLIKHNRPLFISGYLNGLGITRIMIDGGSAVNLLPLRMLKRLGIAIHRLGGEQKRVKADANPFSEAKAKQGEEALITQAQAFTFLVIDQRLGANVGSAQGPTYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NJ87</accession>
    <name>A0A0D2NJ87_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G033700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NJ87"/>
    <dbReference type="Gramene" id="KJB33037">
        <property type="protein sequence ID" value="KJB33037"/>
        <property type="gene ID" value="B456_006G033700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="91" mass="10285" checksum="56B0170E2AD4C262" modified="2015-04-29" version="1" fragment="single">VNFEAPFCLVWIGWALFEELSIPCKLVLNVVVMEETEALIVLKYVLYVLRFDSFSMFNLLKVVLVLPISKECLEGILGSLLNINSTVPSFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NP29</accession>
    <name>A0A0D2NP29_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_002G166800</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADAGIO family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NP29"/>
    <dbReference type="STRING" id="29730.A0A0D2NP29"/>
    <dbReference type="Gramene" id="KJB15243">
        <property type="protein sequence ID" value="KJB15243"/>
        <property type="gene ID" value="B456_002G166800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785569"/>
    <dbReference type="eggNOG" id="ENOG502QWBU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVCWRKF"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007623">
        <property type="term" value="P:circadian rhythm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009637">
        <property type="term" value="P:response to blue light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22154">
        <property type="entry name" value="F-box_AtADO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000041">
        <property type="entry name" value="Adagio protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000005">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000026">
        <property type="entry name" value="Putative LOV domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011498">
        <property type="entry name" value="Kelch_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175:SF2">
        <property type="entry name" value="ADAGIO PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46175">
        <property type="entry name" value="BACTERIOOPSIN TRANSCRIPTIONAL ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07646">
        <property type="entry name" value="Kelch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0090">Biological rhythms</keyword>
    <keyword evidence="11" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0287">Flowering</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="72"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="629" mass="69946" checksum="30F13FF88AFA7419" modified="2015-04-29" version="1">MSKGEEVMQSSGKRQRFAKDEVKRQEMEEQQQQEDDEEEEESQLPKKPGLLYYPTTPTSFVVSDALEPDFPIIYVNKVFEVFTGYRADEVLGRNCRFLQYRDQCAQRRHPLVDPFVVSEIRRCLEEGIEFQGELLNFRKDGTPLVNILKLAPIHDDDGIVTHIIGIQVFSEAKLDLNRVSYPVFKETCNQQLDESAQYSHFSNPPFSQHREICGILQLSDEVLAHNILSRLTPRDVASIGSVCRRIRQLTKNEHVRKMVCQNAWGREVTGTLEMMTKKLGWGRLARELTTLEAVCWRKLTVGGAVEPSRCNFSACAAGNRLVLFGGEGVNMQPMDDTFVLNLDAANPVWQRVSVESSPPGRWGHTLSCLNGSWLVVFGGCGRQGLLNDVFVLDLDAKQPTWKEVSGGAPPLPRSWHSSCTIDGSKLVVSGGCTDAGVLLSDTYLLDLTTDKPTWKEIPTSWAPPSRLGHSLSVYGRTKILMFGGLAKSGNLRLRSGEAYTIDLEDEEPQWRQLDCSAFTSVGSQNAVVPPPRLDHVAVSMPCGRIIIFGGSIAGLHSPSQLFLLDPSEEKPSWRTLNVPGQPPKFAWGHSTCVVGGTRVLVLGGHTGEEWILNELHELCLASRQDSDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQ94</accession>
    <name>A0A0D2NQ94_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G193800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQ94"/>
    <dbReference type="STRING" id="29730.A0A0D2NQ94"/>
    <dbReference type="Gramene" id="KJB15753">
        <property type="protein sequence ID" value="KJB15753"/>
        <property type="gene ID" value="B456_002G193800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEMIHGE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF25">
        <property type="entry name" value="AMIDASE C869.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265542" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB15753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="52741" checksum="89974857620BD226" modified="2015-04-29" version="1">MAVKALLFLQWIIVSVLNLNPLLRSVLEINPHARVQAEEADRQRRSNSHHPRSFSHGVPMLLKDTIATDDKMNTTAGSYALLGSVVGQDAGVVEKLMNVGAVILGMASLTEWYSFRALAKIPNGWCARGGQAQLLQDPCGSSSGSAISMAANMVTVSLGSETHGSILYPADYNSVVRLKPTVGLTSRAGVVPISSRQDTIGPMARTVADAVNLLDAIVGFDPEDSEATSEAAQFIPDGGYKQFLNEDGIIGKDWGLITWNYSDSIRSGELMLLQAEFKSSVNEYLKELAISSVRSLADIIDFNQNNPELEKLEEYGQQTLIESERTNGIWEKERKAAEYLEKLSRDGFEKKMKDYKLDALVTPGISLAMTVLAIGGYPGISVPAGYQSVGMPFGIYFGGLKGSEPKLIEMAYAFEQATRLRKPPPQFFQLTNHFLFGTFWVLKGMVGFDFKDLLLTQPNILDPARSNTCLRGVRLKLKFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NU43</accession>
    <name>A0A0D2NU43_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G173400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB36727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2NU43"/>
    <dbReference type="STRING" id="29730.A0A0D2NU43"/>
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        <property type="protein sequence ID" value="KJB36727"/>
        <property type="gene ID" value="B456_006G173400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799855"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37731">
        <property type="entry name" value="PEPTIDE TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDE TRANSPORTER FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB36727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="303" mass="34044" checksum="CF4214692F9D4991" modified="2015-04-29" version="1">MNSITSPVSCTIDDKDLDDAALWAVIDSAAASHSSSKHRKPLAIKYHSHQSPPTPVSDPSPPRKLPQQKVQNPNHQFYSPPSANCRRFTNSGEDCHRPYKIARSCASEVSETSPVAIVQRTPITSLPERSPEMYLSPGFGRVDVNGSEVSRGSSVRSEEKEGMRHSLSGMFPSVALFKQYQNAAMAILEKSDYTMISGNPFIKKSGWRKISFYFNLSYEIKDKNIEFDENRNVQRAEFVVRAYMQGGRFSDGWGSCERREKRFLKPNHDIPSTAETRAKNKACQDLLGIGEYRTGASQFQRQI</sequence>
</entry>
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    <accession>A0A0D2NWQ1</accession>
    <name>A0A0D2NWQ1_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G0536002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB18453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NWQ1"/>
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        <property type="protein sequence ID" value="KJB18453"/>
        <property type="gene ID" value="B456_003G0536002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB18453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="59" mass="6855" checksum="B9EAD6054C77BEC2" modified="2015-04-29" version="1" fragment="single">ASCDNKHRSGRSRYWFLTRCRVIELQSFWVCVHAIFGHDTQANLEMSFGCSQTMTLGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2G1</accession>
    <name>A0A0D2P2G1_GOSRA</name>
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        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G036500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="6">Binds to the translation initiation factors TIF3E1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB39897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2P2G1"/>
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        <property type="protein sequence ID" value="KJB39897"/>
        <property type="gene ID" value="B456_007G036500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802039"/>
    <dbReference type="eggNOG" id="KOG3301">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQFITHG"/>
    <dbReference type="OrthoDB" id="1557636at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
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        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF47">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="11">
        <location>
            <begin position="8"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="10">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00064713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB39897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="197" mass="23068" checksum="9FFDB84628B6A981" modified="2015-04-29" version="1">MVHVSFYRNYGKTFKKPRRPYEKERLDAELRLVGEYGLRCKRELWRVQYALSRIRNAARDLLTLDEKNPRRIFEGEALLRRMNRYGLLDESQNKLDYVLALTVENFLERRLQTLVFKTGMAKSIHHARVLIRQRHIRVGRQVVNIPSFMVRVDSQKHIDFSLTSPFGGGRPGRVKRKNQRAAAKKAAGGDGDEEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4Y6</accession>
    <name>A0A0D2P4Y6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIR1-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G011400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4Y6"/>
    <dbReference type="STRING" id="29730.A0A0D2P4Y6"/>
    <dbReference type="Gramene" id="KJB21738">
        <property type="protein sequence ID" value="KJB21738"/>
        <property type="gene ID" value="B456_004G011400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790034"/>
    <dbReference type="OMA" id="YINIFLE"/>
    <dbReference type="OrthoDB" id="1930194at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055281">
        <property type="entry name" value="GIR1-2/SIED1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056440">
        <property type="entry name" value="Zn-ribbon_GIR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33177:SF79">
        <property type="entry name" value="LITAF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33177">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24747">
        <property type="entry name" value="Zn-ribbon_GIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIR1-like zinc ribbon" evidence="2">
        <location>
            <begin position="114"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB21738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="159" mass="17626" checksum="9C4CC1361709EC7F" modified="2015-04-29" version="1">MLHLPIFLPTLNSKSSYINIFLETSYYYLISHFVHLEIGCFEGLFSPKVKKTTSRSPNQGLKLNSTSTTPARGSQSMSVSPPEISPENSCLSSEPGDEKEAASVVTMRNRPEVTTMLLVGCPRCLIYVMLSKVEPKCPQCKSTVLLDFLDEETAKWAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P793</accession>
    <name>A0A0D2P793_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G112300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P793"/>
    <dbReference type="STRING" id="29730.A0A0D2P793"/>
    <dbReference type="Gramene" id="KJB41612">
        <property type="protein sequence ID" value="KJB41612"/>
        <property type="gene ID" value="B456_007G112300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41613">
        <property type="protein sequence ID" value="KJB41613"/>
        <property type="gene ID" value="B456_007G112300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802840"/>
    <dbReference type="eggNOG" id="KOG0117">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3800936at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000585">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000808">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein Q isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000259">
        <property type="entry name" value="RNA-binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21245">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="105"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="280"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="437"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="453"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB41612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="52792" checksum="9E979330908B06D0" modified="2015-04-29" version="1">MAENAEVDERVDLDDNYMEEEDDDVEEHVDEDGVDSGGDENGEENDEEEFEDSKSGVDGKDQSLEVERSHIETEHVEDEEKPTASISEEEKEKHAQLLALPPNGSEVFIGGLPKDTSEEDLRELCEAIGEIFEIRLIKDKESGESKGYAFVAFKTKEVAEKAVDELHSKEFRGKTIRCSFSETKNRLFIGNIPKSLTEDDFRKAIESVGPGVENIELIKDPLNVNRNRGFAFVLYYNNACADYSRQKMASANFKLDGNNPTVTWADPKSSPDHSAASQVKALYVKNIPDNTSTEKLKEVFQRHGEVTKVVMPPGKAGKRDFGFIHYAERSSALKAVKDTEKYEIDGQVLEVVLAKPQADKKTDAAYPYIAGLNPNHLQHPGYGGFTGTTYGSPSAGFGAATSFQQPVIYGRGPMPTNMAMVPMVLPDGRIGYVLQQPGVQMPTPRPRRVDRGNGPGGGAGRSGNSGGVEGNRSRRYRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P7K8</accession>
    <name>A0A0D2P7K8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G061000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CONSTANS family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P7K8"/>
    <dbReference type="STRING" id="29730.A0A0D2P7K8"/>
    <dbReference type="Gramene" id="KJB22688">
        <property type="protein sequence ID" value="KJB22688"/>
        <property type="gene ID" value="B456_004G061000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22689">
        <property type="protein sequence ID" value="KJB22689"/>
        <property type="gene ID" value="B456_004G061000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790521"/>
    <dbReference type="eggNOG" id="ENOG502QUBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010402">
        <property type="entry name" value="CCT_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF131">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06203">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51017">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="CCT" evidence="11">
        <location>
            <begin position="360"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB22688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="417" mass="45458" checksum="B28A62A42BFBECDA" modified="2015-04-29" version="1">MGYNCDFCGHQRPVVYCRSDAACLCLSCDRNVHSANALSRRHSRTLLCERCNSQPALVRCTEERVSLCENCDWIGHGTSTSNSTHKRQTINCYSGCPSSAELSSLWPFFWQSPSPGESTCEKELGLMSITENIETTSWGPTGNTVSQNKNSAGVAEVNNDNNADMGSGWDGSSSILELRSPPLALDQPAGVTDTSLPKVSCPQTKRPSLYEDDLYDDFNMDEVDLNLDNYEELFGVALNHSEELFESGGIDSLFRTNDLSAADSDCRGAVAAEGSSVGLVNAIQPACSNGASADSVMSNKTDSVLCFTGRQAHSSLSFSGLTGESSGADYQDCGASSMLLMGEPPWCPPCTESSFQSSTRSNAVMRYKEKKKTRKFEKRVRYASRKARADVRKRVKGRFVKAGDAYDYDPLNQTQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PIP1</accession>
    <name>A0A0D2PIP1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G261400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PIP1"/>
    <dbReference type="STRING" id="29730.A0A0D2PIP1"/>
    <dbReference type="Gramene" id="KJB26817">
        <property type="protein sequence ID" value="KJB26817"/>
        <property type="gene ID" value="B456_004G261400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26818">
        <property type="protein sequence ID" value="KJB26818"/>
        <property type="gene ID" value="B456_004G261400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792704"/>
    <dbReference type="eggNOG" id="KOG0055">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PEVMFFD"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03261">
        <property type="entry name" value="ABC_Org_Solvent_Resistant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023">
        <property type="entry name" value="PROTEIN TRIGALACTOSYLDIACYLGLYCEROL 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF3">
        <property type="entry name" value="PROTEIN TRIGALACTOSYLDIACYLGLYCEROL 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="89"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB26818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="349" mass="38259" checksum="CB88DA071401599F" modified="2015-04-29" version="1">MTSATFSSSLLGPFPVVTSTRHCDLGKERNKFCCFNEKKGQRNVICACMAPPTRNLGRDEFHGTKFTESSKYGNFSKEVKHENDSDVLIECRNVYKSFGEKHILRGVSFKIRHGEAVGIIGPSGTGKSTILKIIAGLLAPDKGEVYIRGKKRMGLIGDDEISGLRIGLVFQSAALFDSLTVRENVGFLLYENSCMSDEQISQLVTETLAAVGLKGVEERLPSELSGGMKKRVALARSIICDISKESIEPEVLLYDEPTAGLDPIASTVVEDLIRSVHTKGEDASGKQGKIASYVVVTHQHSTILRAVDRLLFLHEGKVVWQGMTEEFTTSTNPIVRQFASGNLDGPIRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PL33</accession>
    <name>A0A0D2PL33_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G180200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PL33"/>
    <dbReference type="Gramene" id="KJB46802">
        <property type="protein sequence ID" value="KJB46802"/>
        <property type="gene ID" value="B456_008G180200"/>
    </dbReference>
    <dbReference type="OMA" id="TVWLPDN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB46802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="9074" checksum="889650416EF6917B" modified="2015-04-29" version="1">MMYSFNRIAKSITKPVMYTIHSKFGKPHLNLTTLFKTLSTKPPQNGKDDSWNDAWETVWLPDNIFSSQKILGFICDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLM0</accession>
    <name>A0A0D2PLM0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G003500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant LTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLM0"/>
    <dbReference type="STRING" id="29730.A0A0D2PLM0"/>
    <dbReference type="Gramene" id="KJB46977">
        <property type="protein sequence ID" value="KJB46977"/>
        <property type="gene ID" value="B456_008G003500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762606"/>
    <dbReference type="eggNOG" id="ENOG502RZXE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTTSMIN"/>
    <dbReference type="OrthoDB" id="1914452at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00010">
        <property type="entry name" value="AAI_LTSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.110.10:FF:000001">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.110.10">
        <property type="entry name" value="Plant lipid-transfer and hydrophobic proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036312">
        <property type="entry name" value="Bifun_inhib/LTP/seed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016140">
        <property type="entry name" value="Bifunc_inhib/LTP/seed_store"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043325">
        <property type="entry name" value="LTSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33044">
        <property type="entry name" value="BIFUNCTIONAL INHIBITOR/LIPID-TRANSFER PROTEIN/SEED STORAGE 2S ALBUMIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14368">
        <property type="entry name" value="LTP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00499">
        <property type="entry name" value="AAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47699">
        <property type="entry name" value="Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265908" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Bifunctional inhibitor/plant lipid transfer protein/seed storage helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="135"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB46977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="20720" checksum="7D7782DAEF224CF7" modified="2015-04-29" version="1">MEGFKVLHLIAILSTLSMVSVNGQISTACTASMISSFTPCLNFITGSSGNGSSSPTQGCCGSLKSLMSTSMDCACLIITASVPFQLPINRTLALSLPRACNMGGVPVQCKASGTPLPAPGPVPFLLPPTLAPAAASPLSPGASEASTPESDTPLDLAPASPPEAPSATMNPGIRPVLQPSASTPSYVSLPLAFTLLIGTTIFKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PY60</accession>
    <name>A0A0D2PY60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fumarylacetoacetase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G028600</name>
        <name evidence="6" type="ORF">Gorai_022177</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB11939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0579936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PY60"/>
    <dbReference type="STRING" id="29730.A0A0D2PY60"/>
    <dbReference type="Gramene" id="KJB11939">
        <property type="protein sequence ID" value="KJB11939"/>
        <property type="gene ID" value="B456_002G028600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775205"/>
    <dbReference type="eggNOG" id="KOG1535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCRKVIC"/>
    <dbReference type="OrthoDB" id="411064at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050163">
        <property type="term" value="F:oxaloacetate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="4">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB11939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0579936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="225" mass="23986" checksum="0479802BBCFA5216" modified="2015-04-29" version="1">MAAAGSLQNLLKLGTKIVGVGRNYAAHAKELGNAVPKEPVLFLKPTSSYLENGGTIEVPHPLNSLDYEVELAVVIGKTARDVPENTAMNYVGGYALALDMTAREIQSVAKSAGLPWTVAKGQDTFTPISSVFSVSMVPNPDNLELWLKVDDEIRQKGSTKDMIFKIPYLISHISSIMTLFEGDTILTGTPQGVGPVKVGQKITAGITGLVDVCFDVGKRQKPGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q3L4</accession>
    <name>A0A0D2Q3L4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3700 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G052600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q3L4"/>
    <dbReference type="Gramene" id="KJB34178">
        <property type="protein sequence ID" value="KJB34178"/>
        <property type="gene ID" value="B456_006G052600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB34180">
        <property type="protein sequence ID" value="KJB34180"/>
        <property type="gene ID" value="B456_006G052600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB34183">
        <property type="protein sequence ID" value="KJB34183"/>
        <property type="gene ID" value="B456_006G052600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798584"/>
    <dbReference type="eggNOG" id="ENOG502QT10">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEHENMQ"/>
    <dbReference type="OrthoDB" id="2019121at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd01910">
        <property type="entry name" value="Wali7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024286">
        <property type="entry name" value="DUF3700"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044828">
        <property type="entry name" value="TSJT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952">
        <property type="entry name" value="ALUMINUM INDUCED PROTEIN WITH YGL AND LRDR MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45952:SF5">
        <property type="entry name" value="ALUMINUM INDUCED PROTEIN WITH YGL AND LRDR MOTIFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12481">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01172">
        <property type="entry name" value="DUF3700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3700" evidence="1">
        <location>
            <begin position="2"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB34178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="236" mass="25370" checksum="60B23550CFDC8A3D" modified="2015-04-29" version="1">MLGVFSSAIVSPPDELVAAGCRTPSPKITADALVKRFLETNSSGVSMQIGDHVQFAYSHHKESPLQPRSFAVKDEIFCLFEGALDNLGSLKQQYGLAKSANEVILVIEAYKALRDRAPYPPNHVVGHLIGSFAFIVFDKSTSTLFVASDQFGKVPLYWGITADGYVAFADNAELLKGACGKSLASFPQGCFYSTAVGGLRSYENPKNKITAVPAEEEEIWGAKFKVEGPAVVAATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q9I5</accession>
    <name>A0A0D2Q9I5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2 8">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G203400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 8">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2 8"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q9I5"/>
    <dbReference type="STRING" id="29730.A0A0D2Q9I5"/>
    <dbReference type="Gramene" id="KJB15914">
        <property type="protein sequence ID" value="KJB15914"/>
        <property type="gene ID" value="B456_002G203400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785966"/>
    <dbReference type="eggNOG" id="ENOG502QRUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPSQRHI"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:cytokinin riboside 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000005">
        <property type="entry name" value="CASP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF14">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="230" mass="25336" checksum="70CEC8CDFF24736F" modified="2015-04-29" version="1">MEMEGKVVKSRFKRVCVFCGSSTGKRKCYRDAAVELAQELVARRLDLVYGGGSIGLMGLVSQAVHHAGGNVLGIIPRTLMSKEITGETVGEVRPVANMHQRKAEMARHSDCFIALPGGYGTLEELLEVITWAQLGIHDKPVGLLNVDGYYNYLLTFIDKAVDDGFIKPSQRHIIVSAPNATELVQKLEEYVPVHDGIIAKASWEVEQQQQQQVPQQVGFNATTFQTQIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QE09</accession>
    <name>A0A0D2QE09_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G008900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QE09"/>
    <dbReference type="STRING" id="29730.A0A0D2QE09"/>
    <dbReference type="Gramene" id="KJB17638">
        <property type="protein sequence ID" value="KJB17638"/>
        <property type="gene ID" value="B456_003G008900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB17639">
        <property type="protein sequence ID" value="KJB17639"/>
        <property type="gene ID" value="B456_003G008900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787469"/>
    <dbReference type="eggNOG" id="KOG2198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KYEKWGW"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023269">
        <property type="entry name" value="RCMT_subfamily_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF16">
        <property type="entry name" value="SAM-DEPENDENT MTASE RSMB_NOP-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02010">
        <property type="entry name" value="RCMT9"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="16"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB17639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="393" mass="43770" checksum="B92E5700B6CC7B09" modified="2015-04-29" version="1">MEEPSKSPLPEAFLRFLQANGIDPSIYIASDSTPRYLRLKPGNEAEIDGIEAEIKCKLEKVNWLPGFYSLRPDILIANSKSYLDGKIYGIDAASGAAVSVLNISPGDHVLDLCAAPGAKLCMMLDLLGDSGSVTGVDVARHRLAACRTMLQKYSLGDRCRLFVADGTTFSLAPLRVDSRSRSCESSFEEKDERFREWTSRRPWKERKRAAKARETMSLQSVTTSENPELIFYGRHSGVVGLSKNKLYKTMSDLEVSSCGYDKVLVDAECTHDGSVKHIQKFENWGWTTLQRRVLDAVRTDSLTLLQLKLLRNGFRLLKVGGLLVYSTCSLTVAQNEDIVEQFLKENAPAELQEINEAEEWPCKSGRIPKTLRFDPLTSQTSGLFVAKFTKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QF03</accession>
    <name>A0A0D2QF03_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G132000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QF03"/>
    <dbReference type="STRING" id="29730.A0A0D2QF03"/>
    <dbReference type="Gramene" id="KJB56678">
        <property type="protein sequence ID" value="KJB56678"/>
        <property type="gene ID" value="B456_009G132000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56682">
        <property type="protein sequence ID" value="KJB56682"/>
        <property type="gene ID" value="B456_009G132000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768351"/>
    <dbReference type="eggNOG" id="KOG0257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIGYMVI"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF5">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="33"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB56682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="394" mass="43387" checksum="3286A3803436AA28" modified="2015-04-29" version="1">MGSNGMLARRIVETEMPIMVQIQQLIRGAKNAVSLAQGVVYWKPPKQALDKVKALVEEPSVSCYGADEGLPELREALIRKLRQENNLQRSSVMVTAGANQAFVNLVLTLCDAGDSVVMFAPYYFNAYMSFQMTGVTKILVGPGYPKTLYPDADWLERTLLETKPVPKLVTVVNPGNPSGTYIPEPLLKRISDICKNAGCWLVVDNTYEYFMYDGLKHSCVEGDHIVNIFSFSKAYGMMGWRVGYIAYPTEVEGLATQLLKVQDNIPICASLISQQLALHSLELGPEWVREQVKDLVKNREIVIEALSPLGEGAVLGGEGAIYLWATLPEKCMDDVKVVHWLAHRHGVVVIPGSACGSPGHLRISFGGLMENDCRAAAQRLKTGLEELVKHGLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJH6</accession>
    <name>A0A0D2QJH6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">8-amino-7-oxononanoate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G261300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB17026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJH6"/>
    <dbReference type="STRING" id="29730.A0A0D2QJH6"/>
    <dbReference type="Gramene" id="KJB17026">
        <property type="protein sequence ID" value="KJB17026"/>
        <property type="gene ID" value="B456_002G261300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786535"/>
    <dbReference type="eggNOG" id="ENOG502QV7I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWRKGAV"/>
    <dbReference type="OrthoDB" id="515004at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35731">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35731:SF1">
        <property type="entry name" value="8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="29165" checksum="C68AD813F1AC1054" modified="2015-04-29" version="1">MMIALKAIQASFTYSSNHVFFQTRRITTYTKNPILCLSKSNDSESDSDPEPEGDTRKQDLLAQIAMLQAQKVRLTDYLDERSAYLTQFAEEANAEFDKVGEDALKGLEEASERIMENIESQMQAFKESQELNMQEIEMNEDQLAEFEDQMEKERNEGLFFKNLTEKKPIDTAKAMEEAEKVKEVTKEKVGSKARRNLYLALITVLAVGIADSLVTGSDWRKVAVLGAILVALFSQFIYEQTVLSEEEKTEKNDENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJR0</accession>
    <name>A0A0D2QJR0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G203200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJR0"/>
    <dbReference type="STRING" id="29730.A0A0D2QJR0"/>
    <dbReference type="Gramene" id="KJB58297">
        <property type="protein sequence ID" value="KJB58297"/>
        <property type="gene ID" value="B456_009G203200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770505"/>
    <dbReference type="eggNOG" id="ENOG502QWQZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020737at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010608">
        <property type="entry name" value="DUF1195"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34358:SF13">
        <property type="entry name" value="GENOME ASSEMBLY, CHROMOSOME: A08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34358">
        <property type="entry name" value="OS03G0411600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06708">
        <property type="entry name" value="DUF1195"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="182" mass="20366" checksum="723C2B9F5B408E1F" modified="2015-04-29" version="1">MKEQDSPTTPPIPITSQQLATPSVVKKDSSVTAGFLGKSGYKFWVLAAILLLAFWSMFTGSVSLKWSSGHLTAFSDDIDFSVYDDLDVLELEEREKVVRKMWDVYTHSASVRLPRFWLEAFEAAYEYLSSDVPGVRDTAMSEIAKLSMRSLNLDSPSLRSKSISVGKENSNRKEISASRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QL33</accession>
    <name>A0A0D2QL33_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G005200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Bifunctional nuclease with both RNase and DNase activities. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bifunctional nuclease family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QL33"/>
    <dbReference type="STRING" id="29730.A0A0D2QL33"/>
    <dbReference type="Gramene" id="KJB17546">
        <property type="protein sequence ID" value="KJB17546"/>
        <property type="gene ID" value="B456_003G005200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787427"/>
    <dbReference type="OMA" id="QFQLMRN"/>
    <dbReference type="OrthoDB" id="566255at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030891">
        <property type="term" value="C:VCB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="entry name" value="Bifunctional nuclease domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15160:SF1">
        <property type="entry name" value="VON HIPPEL-LINDAU DISEASE TUMOR SUPPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15160">
        <property type="entry name" value="VON HIPPEL-LINDAU PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="BFN_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="Hypothetical protein TM0160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="4">
        <location>
            <begin position="114"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB17546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="318" mass="36204" checksum="9EC7CBECA11541E1" modified="2015-04-29" version="1">MLGAQLCYRTFSTFWVFSHKSNATTYPTIPAFSFPSIRSSSIRLHFPAKLRPVSCHSIRSGSFDPQFNEDDDKDLQFLEASLLVSETVSHYRMLRQGITEEIKWQSSRREQHPISRAKIASIGQSFLSRFPTPTIFLKISCDGDFLLPIIVGEFAVEKLIASFWGDDNGECPDQFHLVKNVVEKLGYEVKMVRITERVVNTYFAKLYFSKPGENDVISVDARPSDAINVAHRCKAPIYVSKQIVLEDAIRIGFGMGRVRDTTPTYDVVLDSAMEGPDLLTEELDLVRNMNLAVEEERYNDAAMLRDELMKLRNSSRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNH2</accession>
    <name>A0A0D2QNH2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G260700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNH2"/>
    <dbReference type="Gramene" id="KJB59552">
        <property type="protein sequence ID" value="KJB59552"/>
        <property type="gene ID" value="B456_009G260700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769902"/>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CANQNVG"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF258">
        <property type="entry name" value="LACCASE-12-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249924" description="Plastocyanin-like domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="35"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="153"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB59552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32410" checksum="8E9690759B9B3504" modified="2015-04-29" version="1">MGSEKQGFIWLSGLLFLNILALSTAEVLYYEFFLQESQFTKLCSTKSILTVNGSFPGPEIRVRRGDTVFVNVHNQGNHAVSLKWEGVKDSIDGSNELIQPGRNFTYEIELEDEIGTLWWHATSAWAAATVHGAFVILPAANEDYPFPAPTSDQTIILGEWFREELTEANQTIAPGSADAYTINGHPGETYGCSNDTTYEMQVDYEGLYLVRVINAIANETMVFGVASHSFTIVGQSGAYSRRSFTNSLTLAPAQVVDVLLCANQNVGHYYITARPSSGAHITNGILRYTTTSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QP35</accession>
    <name>A0A0D2QP35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G273900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QP35"/>
    <dbReference type="STRING" id="29730.A0A0D2QP35"/>
    <dbReference type="Gramene" id="KJB59814">
        <property type="protein sequence ID" value="KJB59814"/>
        <property type="gene ID" value="B456_009G273900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB59817">
        <property type="protein sequence ID" value="KJB59817"/>
        <property type="gene ID" value="B456_009G273900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770071"/>
    <dbReference type="eggNOG" id="KOG4666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071618">
        <property type="term" value="F:lysophosphatidylethanolamine acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
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    </dbReference>
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        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="15">
        <location>
            <begin position="177"/>
            <end position="292"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB59817.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="396" mass="44523" checksum="D62BEA82B451E3A7" modified="2015-04-29" version="1">MESELRGFNTKPSKTPQPDPTHDDASSRDDRPLLTSASNVLELEKKCAAYVRNDVYGAMGRGELLLMEKLQLGIAFVTLLPLRTILVMTVLVVYYLICRICTLFSVPNHGEGQEDYAHLGGWRRTVILRSGRFLSKTLLFLVGFYRINETHNGSKNSQENSKTAGTLQPDEPEQRPGAIVSNHISYLDILYHMSSSFPSFVAKRSVANIPLVGLISKCLGCVYVQRESKSSDFKGVSGVVTDRVRKAHQDEYAPKILLFPEGTTTNGDYLISFKTGAFLARAPVVPVILKYPYQRFSPAWESVTGMRHVVFLLCQFVNHMEVTWLPVYYPSQLEKDDPKLYANNVRRLMASEGNLILSDIGLAEKRIYLATLNETNQRDGFTFLIEPKMTPFAVIL</sequence>
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    <accession>A0A0D2QSZ8</accession>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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        <property type="gene ID" value="B456_003G133500"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QUQ0"/>
    <dbReference type="Gramene" id="KJB10920">
        <property type="protein sequence ID" value="KJB10920"/>
        <property type="gene ID" value="B456_001G232600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804597"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="STHGCIT"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:RNA modification"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="E_motif"/>
    </dbReference>
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        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015">
        <property type="entry name" value="OS07G0578800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015:SF908">
        <property type="entry name" value="OS10G0540100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
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    </dbReference>
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        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="167"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="267"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0579474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="64689" checksum="425D0A45A766D8DB" modified="2015-04-29" version="1">MQSLKWRKHLKPLLLACEDKKPLAKIHALMIQTGHKNSVGNLIASYARVGDILSARKVFDKLSNRRVNSWNAMILAYSRKSFPKEVLDLYRQMIMEGIKPDSTTFTMAIKACVSLMDMEMGDEIWRKAVDFGYQKDVFVASSILNLYVKCGKMDEAMVVFNGMPRKDLVCWTTMVTGLAQSGRASEAIDSYRKMRMEGMEGDSVMMLGLIQASVNLGDSKLGRTIHGYMIRKGLSMDVVVQTSLVDMYAKNGYLEYALHVFKMPTKNDISWGALISGLAQNGFARNALELLVQMQGCGFKPDSMSLVGALLACSQCGLLKLGKSTHGCITRRFDLEPVSGTAMIDMYAKCGSLSYARALFDRIASKDIISWNVMIASYGVHGHGKEALSLFLKMTKMSLKPDHATFAALLSALSHSGMVNEGRYWFNFMVNEYGIQPIEKHYTCMVDLLARAGLVEEAYKLIGSMNNKPGVAVWVALLSGCRNHGKLSIGEMAAKKVLELNPDDLGIHALVSNFFAMGNMWDEVAVVKKLMKDSGKKKVPGYSVLDVDGKLHAFLMGDKSHHEYKAIATVLDNLDREMSFIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QUT8</accession>
    <name>A0A0D2QUT8_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
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    <gene>
        <name evidence="4" type="ORF">B456_001G233400</name>
        <name evidence="5" type="ORF">Gorai_021734</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QUT8"/>
    <dbReference type="Gramene" id="KJB10950">
        <property type="protein sequence ID" value="KJB10950"/>
        <property type="gene ID" value="B456_001G233400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804691"/>
    <dbReference type="eggNOG" id="ENOG502S1HQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TATTMEI"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46629">
        <property type="entry name" value="OS01G0917900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="284"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="150"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0579479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="332" mass="36320" checksum="A0164424CDD65AEB" modified="2015-04-29" version="1">MEGGNRRRLTLFEQISAVENGRDALAGLTLDAVLGNAKRPEQPPAQNRTLLEIIRDDGSNKGKKSWKALRDKLRLKRLAVSARTSSVRIPASDVIVNDNNRSQFSRQGSFRSHSADPTGVEDRGGSAPVSDPTVMNSRPQLARFGSGRFVQDHESEISRQHLTPFPSSNNARNNADSSEDEDDDSPVARDETRRLGAALEEERALSAREAAAAQEAATVAETNARPIGSTEEPVRMSLMDFLEETERQMGLTGSKCTTGDADADDEENEEKDKAEGSGGMEQTCCVCMVRHKGAAFIPCGHTFCRLCSRELWVQRGNCPLCNGTIQEILDIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R009</accession>
    <name>A0A0D2R009_GOSRA</name>
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        <recommendedName>
            <fullName evidence="1">DUF4371 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G270900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R009"/>
    <dbReference type="STRING" id="29730.A0A0D2R009"/>
    <dbReference type="Gramene" id="KJB44753">
        <property type="protein sequence ID" value="KJB44753"/>
        <property type="gene ID" value="B456_007G270900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWCA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIEMIRI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055298">
        <property type="entry name" value="AtLOH3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025398">
        <property type="entry name" value="DUF4371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 2-RELATED ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11697:SF230">
        <property type="entry name" value="ZINC FINGER, MYM DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14291">
        <property type="entry name" value="DUF4371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4371" evidence="1">
        <location>
            <begin position="40"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB44753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="435" mass="49856" checksum="1FF3F19C90272AEC" modified="2015-04-29" version="1">MFGINLKWDVLQCQLAEHVRWIIEKLTLSWVNDDSMCGDGFIRERSFDLVHVKDTTSLALEKAIHEVLLLHCLNVDDIHGQGYDGASNMRGECNGLQALFAKKCYSYLSIVLYLTDIINLAAFSNKWHEQLRDTESSHIAKLIDTSELETGKGKNQVDTLQRLGDTRWGSHLASLNSLIRMFDSVCVVLQDIIKSGNLTQRSEVDGIYDAMISIKFVFILHFMIEMIRITDDLCEALQYKPQDILNAMQLEVKLFCKDHEIEVPNLSAPYKVGRGRSCIQRENLTIEHHYRLDIFIVGIDSLLTKMNSPFNDEVVELLVLSSALDPHDYKAFSVEDIYKLMNSFYPDDYTEQEKLHMKIQLEHFQLYVHQSTELQKASIVIELSQVLAKTNKSSIYHHLDRIIRLMLTLPMSTTTTERAFSAMKNEDKASQQNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R020</accession>
    <name>A0A0D2R020_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tubulin/FtsZ GTPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G272600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R020"/>
    <dbReference type="STRING" id="29730.A0A0D2R020"/>
    <dbReference type="Gramene" id="KJB44763">
        <property type="protein sequence ID" value="KJB44763"/>
        <property type="gene ID" value="B456_007G272600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1375">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2004">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NWAKGSY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="5">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB44763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="196" mass="21678" checksum="EC16C26AAB3D582A" modified="2015-04-29" version="1">MVRSSKVVNVGTRSGLISGKSYATSMKLTTLENITVTPTFSWSASMSTTMKPVVEGMSHALFSWIWSAILMDLEPGTMDSVRSGPFGQTFRPDNFVFGQSGAGNNWAKGSYTEGAELIDSVLDVFRKEAENCDCLQDFRATISGANKLQCQQVIEELDVHKRLQLTLELVKKEMEISKIQDSIPKAIEEKISGEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1C8</accession>
    <name>A0A0D2R1C8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vps72/YL1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G087700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1C8"/>
    <dbReference type="STRING" id="29730.A0A0D2R1C8"/>
    <dbReference type="Gramene" id="KJB23251">
        <property type="protein sequence ID" value="KJB23251"/>
        <property type="gene ID" value="B456_004G087700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2897">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDIEYEQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB23251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="204" mass="23522" checksum="9E8E30855C2E8BB6" modified="2015-04-29" version="1">MGTGKEDTAVFLDRASRSTRGRRMTKLLDEEVEEDELFWNQEAFKEIQAHTYSSENTLTIFLDYRIDVDEENDVNYEEEPEVADVFDSDFDEDEPEPDEKVENEADERVHTKKRLIFPGKPSMKKKEKKKVLSNLDGDSKDENLTQKTSSTQHHDALDDAEGERIIRKSTRTSVIVRQAERDAIRAALQATMKVHCEVRGSLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R3Q5</accession>
    <name>A0A0D2R3Q5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G246500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R3Q5"/>
    <dbReference type="STRING" id="29730.A0A0D2R3Q5"/>
    <dbReference type="Gramene" id="KJB26543">
        <property type="protein sequence ID" value="KJB26543"/>
        <property type="gene ID" value="B456_004G246500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB26544">
        <property type="protein sequence ID" value="KJB26544"/>
        <property type="gene ID" value="B456_004G246500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792573"/>
    <dbReference type="eggNOG" id="KOG1429">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSFMYID"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047918">
        <property type="term" value="F:GDP-mannose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05273">
        <property type="entry name" value="GME-like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033890">
        <property type="entry name" value="GDP-Man_epi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43574">
        <property type="entry name" value="EPIMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB26544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="376" mass="42424" checksum="D7B59A0AE0A3F794" modified="2015-04-29" version="1">MGSTDGTSYGAYTYDALEREPYWPSEKLRISITGAGGFIASHIARRLKSEGHYIIASDWKKNEHMTEDMFCHEFHLVDLRVMENCLKVTNGVDHVFNLAADMGGMGFIQSNHSVIMYNNTMISFNMLEAARISGVKRFFYASSACIYPEFKQLETNVSLKESDAWPAEPQDAYGLEKLATEELCKHYTKDFGIECRIGRFHNIYGPFGTWKGGREKAPAAFCRKAITSIDKFEMWGDGLQTRSFTFIDECVEGVLRLTKSDFREPVNIGSDEMVSMNEMAEIVLSFEDKKLPIHHIPGPEGVRGRNSDNTLIKEKLGWAPTMRLKDGLRITYFWIKEQIEKEKVQGIDLSVYGSSKVVGTQAPVQLGSLRAADGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4J6</accession>
    <name>A0A0D2R4J6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G141900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4J6"/>
    <dbReference type="STRING" id="29730.A0A0D2R4J6"/>
    <dbReference type="Gramene" id="KJB24356">
        <property type="protein sequence ID" value="KJB24356"/>
        <property type="gene ID" value="B456_004G141900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791436"/>
    <dbReference type="eggNOG" id="KOG0867">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHPWGKI"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009407">
        <property type="term" value="P:toxin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03187">
        <property type="entry name" value="GST_C_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03053">
        <property type="entry name" value="GST_N_Phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000016">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034347">
        <property type="entry name" value="GST_Phi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF47">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE F6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01154">
        <property type="entry name" value="Main.5:_Phi-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="9">
        <location>
            <begin position="91"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB24356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="215" mass="24326" checksum="1CC83D4F381F74F8" modified="2015-04-29" version="1">MAAMKVHGYPLSTATQRVLACLYEKDVEFQFVNVDMVAGEHKSPNFLPLNPFGQVPAFEEGDLKLFESRATTHYIAHEYADKGTQLLLPGSNKTMAVFQLWKEVEAHQFDPPSTKLVFELRYKPHFGMTTDTAVVEEYEAKFAKVLDVYEARLAESKYLACDHFTLADLHHLPTVQYLLGSSAKKLFDSRPHVSAWVADITARPAWSKVMGMLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5J2</accession>
    <name>A0A0D2R5J2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Legumain prodomain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G103000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5J2"/>
    <dbReference type="STRING" id="29730.A0A0D2R5J2"/>
    <dbReference type="MEROPS" id="C13.002"/>
    <dbReference type="Gramene" id="KJB65602">
        <property type="protein sequence ID" value="KJB65602"/>
        <property type="gene ID" value="B456_010G103000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773196"/>
    <dbReference type="eggNOG" id="KOG1348">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21115">
        <property type="entry name" value="legumain_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.130:FF:000001">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1460:FF:000005">
        <property type="entry name" value="Vacuolar-processing enzyme beta-isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043577">
        <property type="entry name" value="AE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048501">
        <property type="entry name" value="Legum_prodom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046427">
        <property type="entry name" value="Legumain_prodom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000">
        <property type="entry name" value="HEMOGLOBINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12000:SF50">
        <property type="entry name" value="VACUOLAR-PROCESSING ENZYME GAMMA-ISOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20985">
        <property type="entry name" value="Legum_prodom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500139">
        <property type="entry name" value="AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262430" description="Legumain prodomain domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Legumain prodomain" evidence="10">
        <location>
            <begin position="375"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB65602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="488" mass="54160" checksum="E46FC7630A5336CE" modified="2015-04-29" version="1">MTTLVTGVFLLLLSVAGVVSAARYITGDVLRLPSEASRFFRWRSDDDEVGGTRWAVLIAGSNGYWNYRHQADVCHAYQLLRNGGLKEENIIVFMYDDIAFNEENPRPGVIINNPHGDDVYKGVPKDYTGEDVNVHNFFAALLGNKSAITGGSGKVVDSGPDDHIFIYYTDHGGPGVLGMPTFPYLYADDLIDVLKKKHASGTYKSMVFYLEACESGSIFEGLLPQGLNIYATTASNAEESSWGTYCPGEYPSPPPEYETCLGDLYSVAWMEDSDMHNLRTETLHQQYELVKKRTINGNSAYGSHVMQYGDVGLSKDSLFAYLGTNPANDNFTFVDENSLVPPTKAVNQRDADLVHFWYKYRKAPEGSVRKTEAQKQFVEAMSHRMHIDHSVKLIGKLLFGIERGLEVLNTVRPAGQPLVDDWKCLKKMVRTFETHCGSLAQYGMKHMRSLANICNAGIQTEQMAEASAQACVSVPTGRWSSLQKGFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R919</accession>
    <name>A0A0D2R919_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein RETICULATA-RELATED 1, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G041900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RETICULATA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R919"/>
    <dbReference type="STRING" id="29730.A0A0D2R919"/>
    <dbReference type="Gramene" id="KJB47793">
        <property type="protein sequence ID" value="KJB47793"/>
        <property type="gene ID" value="B456_008G041900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ0I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009706">
        <property type="term" value="C:chloroplast inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021825">
        <property type="entry name" value="RETICULATA-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31038">
        <property type="entry name" value="EXPRESSED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31038:SF2">
        <property type="entry name" value="PROTEIN RETICULATA-RELATED 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11891">
        <property type="entry name" value="RETICULATA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="96"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB47793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="58108" checksum="F2B0D16FA4487CFC" modified="2015-04-29" version="1">MSHIMFQTSPLPKTLLLKPSLPPPPGKHRKNLTLRCSSSSLIDGGESSVASLERCFLAPPAPVESASSGSGEVGPVMKGGQYGAFGAVTLEKGKLDLSQKQSTSSPELATGGGGGDIGKKINHGGGDGGDDDGDDDDYFDDFDDDGEGEEGGLFRKRMFLEELFDRKFVDAVLNEWHKTMMDLPAGFRQAYEMGLVSSAQMVKFLAINARPTTSRFISRTLPQGMSRAFIGRMLADPAFLYRLLLEEAATIGSSVWWEVKNRKDRIKQEWDLALMNVLTVAACNALVVWSLAPCRSYGNTFRFDLQNTLQKLPNNIFERSYPLREFDLQKRIHSLFYKAAELCIVGLTAGAVQGSLSNFLASKKKEKLSVTIPSMSTNALGYGAFLGLYANLRYQLLCGFDQAMVNHFDVIGVALFFSTALRVLNVQLGERSRLAWLGVEVDPLVQSDDLLKAYNRPSEDGTRSSSKWFISKNAIVSGLGLLGIRQGNAESAANEETRAPKARRKRIVRKKRIQYEREPLAKIFVWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RBZ0</accession>
    <name>A0A0D2RBZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G084600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RBZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2RBZ0"/>
    <dbReference type="Gramene" id="KJB48753">
        <property type="protein sequence ID" value="KJB48753"/>
        <property type="gene ID" value="B456_008G084600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763464"/>
    <dbReference type="eggNOG" id="ENOG502SAQX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YHTTSQN"/>
    <dbReference type="OrthoDB" id="689462at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008889">
        <property type="entry name" value="VQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039610">
        <property type="entry name" value="VQ29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34794">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34794:SF1">
        <property type="entry name" value="OS10G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05678">
        <property type="entry name" value="VQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VQ" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB48753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="184" mass="19911" checksum="7302D3B206AED32C" modified="2015-04-29" version="1">MEAYSSYAAAAAASSSEEARALKAPQASFHGSLHSVRKPLSKPWKKPIAPFPPTPPKVYTVDPINFRDLVQQLTGAPQFMSQSHNQTSTSQFQAQLPQQQRLQRVAPPALHVAAPPLSRTEVSAPLHLVSGLYHTTSQNQNFSDNAMFTSTSLGLTLSPSLFNWCTFPILSPGTLASLEQSTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDA1</accession>
    <name>A0A0D2RDA1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G003200</name>
        <name evidence="9" type="ORF">B456_005G003300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDA1"/>
    <dbReference type="SMR" id="A0A0D2RDA1"/>
    <dbReference type="STRING" id="29730.A0A0D2RDA1"/>
    <dbReference type="Gramene" id="KJB27597">
        <property type="protein sequence ID" value="KJB27597"/>
        <property type="gene ID" value="B456_005G003300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27599">
        <property type="protein sequence ID" value="KJB27599"/>
        <property type="gene ID" value="B456_005G003300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27600">
        <property type="protein sequence ID" value="KJB27600"/>
        <property type="gene ID" value="B456_005G003300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27641">
        <property type="protein sequence ID" value="KJB27641"/>
        <property type="gene ID" value="B456_005G003200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27642">
        <property type="protein sequence ID" value="KJB27642"/>
        <property type="gene ID" value="B456_005G003200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796270"/>
    <dbReference type="KEGG" id="gra:105796271"/>
    <dbReference type="eggNOG" id="KOG0417">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFHWQAT"/>
    <dbReference type="OrthoDB" id="1463766at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB27597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB27641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="148" mass="16492" checksum="5756FB61AFA1A343" modified="2015-04-29" version="1">MASKRILKELKDLQKDPPTSCSAGPVAEDMFHWQATIMGPSDSPYAGGVFLVTIHFPPDYPFKPPKVAFRTKVFHPNINSNGSICLDILKEQWSPALTISKVLLSICSLLTDPNPDDPLVPEIAHMYKTDRAKYEATARSWTQKYAMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDP8</accession>
    <name>A0A0D2RDP8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein uS5c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">30S ribosomal protein S5, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_010G256400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDP8"/>
    <dbReference type="STRING" id="29730.A0A0D2RDP8"/>
    <dbReference type="Gramene" id="KJB68627">
        <property type="protein sequence ID" value="KJB68627"/>
        <property type="gene ID" value="B456_010G256400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68628">
        <property type="protein sequence ID" value="KJB68628"/>
        <property type="gene ID" value="B456_010G256400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68629">
        <property type="protein sequence ID" value="KJB68629"/>
        <property type="gene ID" value="B456_010G256400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772817"/>
    <dbReference type="eggNOG" id="KOG0877">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGPMETE"/>
    <dbReference type="OrthoDB" id="309483at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000001">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_uS5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_uS5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF61">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US5M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="300" mass="32542" checksum="075062028CA12282" modified="2015-04-29" version="1">MAATTTAIALTLSSFTLRSTIPSKTFFFPKPSKPISLRRTFRPLSLTPQAKSSDIDTSFFDDVNPEEDIVFDPPTPPEGFTPPPSFDEGPEETEDEIAAAYEELYGPAYSGVSVLGNDVYVMDSKVKKSSAFGKVKKEKVRDGFEERVVQVRRVTKVVKGGKQLHFRAIVVVGDKQGQVGVGVGKAKEVIGAVQKSAVNARRNIITIPMTKYLTFPHRSEGDYGAAKVMLRPAAPGTGVIAGGAVRIVLEMAGVENALGKQLGSKNALNNARATVVAVQKMKQFREVAQERGIPMEELWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RJZ0</accession>
    <name>A0A0D2RJZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G101700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RJZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2RJZ0"/>
    <dbReference type="Gramene" id="KJB19430">
        <property type="protein sequence ID" value="KJB19430"/>
        <property type="gene ID" value="B456_003G101700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB19431">
        <property type="protein sequence ID" value="KJB19431"/>
        <property type="gene ID" value="B456_003G101700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0116">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYQDSSH"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000003">
        <property type="entry name" value="Nuclear transport factor 2 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF75">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="372"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB19430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50496" checksum="CBA4A531E77D1B06" modified="2015-04-29" version="1">MAMQEGSPVFTPSTQVIGNAFVEQYYHILHQSPNLVHRFYQDSSHLSRPDMHGNMTTVTTLQAINEKVLSLNYEDYTAEIKTADAEDSFEKGIILLVTGSLTGKDNVKKKFAQTFFLAPQDKGYFVLNDVFRYVEEKELQNSVPANGISEQASISALTPEPELTDDQLAKEPLTYSEEEDINNGAEVCDPLDKEEGSVVEEEVVEPQNIAGQNERIVTVDSAPMVPDDAPKQSYASIVKVIKSKASTPVYVPTNNVGAKPVNQRPVLSAKIAPTPAAEVPNSDHAPGSSNDNEEAEGHSIYVRNLPYNATPQQLEEAFRKFGTIKCNGIQVRSNKQGFTFGFVEFENPSSVQSALEASPITIGDRQAAVEEKRTNTRVRSSGRPRYNSSGKGGLRGDSFRARGNFGSGRGGYGRHEIRHPGDFSGQPKGSGGWNGDNNPKGVNRMEGVAIKGGQKQHDSTWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNT0</accession>
    <name>A0A0D2RNT0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TPX2 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G164700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNT0"/>
    <dbReference type="STRING" id="29730.A0A0D2RNT0"/>
    <dbReference type="Gramene" id="KJB20780">
        <property type="protein sequence ID" value="KJB20780"/>
        <property type="gene ID" value="B456_003G164700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSKT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGMRFGA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005880">
        <property type="term" value="C:nuclear microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060236">
        <property type="term" value="P:regulation of mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027330">
        <property type="entry name" value="TPX2_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009675">
        <property type="entry name" value="TPX2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326:SF15">
        <property type="entry name" value="OS06G0130200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14326">
        <property type="entry name" value="TARGETING PROTEIN FOR XKLP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12214">
        <property type="entry name" value="TPX2_importin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 central" evidence="2">
        <location>
            <begin position="275"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB20780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="505" mass="56821" checksum="B3EBD0902289A9B3" modified="2015-04-29" version="1">MEEEMEIEPVFEVSEVDLDYEFDAAQFFDFTREESPSEASDAERWFESAPSYPPSPFVTKLVLGEGSLLENVTTPVKCKEVDDIGRLREDDSELEFSSMDASKREPWSLFPQLRDPLRRACASTGNFMKHEGSNGGIFTSIQKVLLKVLNRPFQLTTGLTTSNNIPDDKPKAESNVTKLFMPRSSTLMKPTASRLAKQNCPPQVASTRFKKLQVPNSDRSLVHSSGVGSQAAKRQKLEGGLTHKVNEVKQQTTFVHKVPKKDVTADRNTINIKPKLTIPREPALRTAHRAQRVLPKNGTKQEHVSSAMHKFKARPLNRKILEAPSLPLPKKSVPKLPEFQEFHLKTSERAVQLPSSVSSSSFQTNDYDKGFVKPCTNSTNRNGTREVRRLDSCDTNYNIKAHLLNKKIFSGKGDLGVSKNIKKETTAPMEYKIRGERRVPQNPPIELFSKLSLTSELQPSNGSQMKVPCPTFISTKGLKENRLISFQPEHEMMMHLAKEKLLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RP53</accession>
    <name>A0A0D2RP53_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_006G021100</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RP53"/>
    <dbReference type="Gramene" id="KJB33604">
        <property type="protein sequence ID" value="KJB33604"/>
        <property type="gene ID" value="B456_006G021100"/>
    </dbReference>
    <dbReference type="OMA" id="QLSWNQI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase MSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000400">
        <property type="entry name" value="Nuclear pore complex protein NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001023">
        <property type="entry name" value="Os07g0541700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051420">
        <property type="entry name" value="Ser_Thr_Kinases_DiverseReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005">
        <property type="entry name" value="LEUCINE RICH REPEAT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48005:SF16">
        <property type="entry name" value="MDIS1-INTERACTING RECEPTOR LIKE KINASE 2-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002263089" description="non-specific serine/threonine protein kinase" evidence="21">
        <location>
            <begin position="28"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="370"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="398"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="573" mass="63525" checksum="B74FA7B2941C3BDB" modified="2015-04-29" version="1">MKSYFSTSIPTFCLLSIMAITSGITRATKSDSEWLAAEAKALMETGWWSNYSRAENHCTWPGIRCNAGSVVEIDLGGHGLNGSITPQIGALSELQILNLSWNSLTALGLLTNLTHLKKLMTLNLRYCDLSGPIPPHIGKLESMVDLDLSQNGLVGPIPSSVSSLTNLSSLFLQSNQLNGSIPEDIGGLTNLVELDLSSNRLSGHIPSSLGQLSGQIPSSLGQLTKLESLYLHHNQINSFIPHEIERLKDLKYLDLSNNWFIGPIPSSTFTGNKDLCGSIQGFHPCPSSPNVNRERNSKVVKHNLLIVILVPTLLFFVSTFVLVTFILFRRYRAKTLKSDSSPTKNGDLFTIWNFDGKIAFEDIIKATEDFDIKYCIGTGGYGSVYRAVLPSGKVIALKKLHRLEAEQPAYDTSFRNEIKFLAEIRHKNIIKLHGFCLHNRCMFLIYEYMENGSLFYALSIDDEAVELDWTKRVNIVKGVAHALSYMHHDCNLPIVHRDISSNNILLNSELEAFIADFGTARLLDPDSSNRTVIVGTYGYIAPGSAPSLSSYLFYLVLSILSFCCLFVSNYILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQV5</accession>
    <name>A0A0D2RQV5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G213300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQV5"/>
    <dbReference type="Gramene" id="KJB73072">
        <property type="protein sequence ID" value="KJB73072"/>
        <property type="gene ID" value="B456_011G213300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775097"/>
    <dbReference type="eggNOG" id="KOG1642">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTNTKPT"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00374">
        <property type="entry name" value="RNase_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF46">
        <property type="entry name" value="INTRACELLULAR RIBONUCLEASE LX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251203" evidence="3">
        <location>
            <begin position="22"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="250" mass="28757" checksum="042821F2754DF82D" modified="2015-04-29" version="1">MQKRQILVVVVVLAGVSLVVSDEDVKPLDFYKYSLQWPPSACTLPPPGKKCEVRHEARFTIHGYWPQYNKDTPVPPYCDDLRCTNTKPTSANDVVGILEKSPLKKDLMKDWPNLYARQRRKEEDNLEFWKYEWRKHGMCSDDANKPSEYFRNSLTLLPNFKNLKQDLGFKPRSKVGDILKNLRDKNYKVPQIVCNSNSQLLEIRFCYRNIAIDCPNWVGSKTCNKETADIFLPGGAGGTDDVKAQLNIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRG6</accession>
    <name>A0A0D2RRG6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper ion binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G010200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G010200"/>
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        <property type="entry name" value="At2g27730-like"/>
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        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="69"/>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB21845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="36" mass="3629" checksum="2700A962B93BBC52" modified="2015-04-29" version="1" fragment="single">KSTGNGAENSGGGKGNEMALGASLWVFTMLLLNFGV</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="component" value="Chromosome 4"/>
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        <property type="entry name" value="Myb/SANT-like_dom"/>
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        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
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        <location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="158"/>
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        </location>
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            <begin position="213"/>
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        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="344" mass="38924" checksum="659AC41D3F40950E" modified="2015-04-29" version="1">MVKTRNFVEGDSSLATKAVWDDELTLIFCELCVNEVNAGNRPTTHLNSKGWENVIALFQAKTQKNYGKPQLKNKWDTLKKEWRLWRELLKESTGIGWCPSKKTVDATEEWWAAKIQENPDFKGFKKKGIEPRLNELMWQMFGGIVATGENAWAPSSGVLPSGVPMGDDAPYEGFGDSDEHSNENEGIPPDEVPSNPSHEIPNRRKQTLGAAHGKGKKSSSSRKSSRNTLTTQIEKLCESMASPRKSVNEIIFPHSQYTISNAMDALRALGDEIPKRDELYYFATKMFQIPVKREMFLNLDPDDRVWWLRREYAEQNTIASFSSLVATSSFPFQPYHQPPPPSAP</sequence>
</entry>
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    <name>A0A0D2RWG2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Nuclear pore complex protein NUP214</fullName>
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    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G097900</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>eudicotyledons</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
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                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Dennis E.S."/>
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                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S023</accession>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 12"/>
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            <begin position="1"/>
            <end position="25"/>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S089</accession>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S089"/>
    <dbReference type="Gramene" id="KJB56778">
        <property type="protein sequence ID" value="KJB56778"/>
        <property type="gene ID" value="B456_009G135700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769696"/>
    <dbReference type="eggNOG" id="KOG1237">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYNYYYW"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17416">
        <property type="entry name" value="MFS_NPF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB56778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0594904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="63810" checksum="B4915909E8571CE1" modified="2015-04-29" version="1">MEDTKMEDSSNQREMSHEEMPETHSKGGLITMPFIIANESFEKVASYGLVPNMILYLIKDYHMGVAKGTNILFFWQAATNFTPILGAFVADSYLGRFLTIGLGSICSLLGMILLWLTAMVPQSKPPPCDLMTQTCSSPTSAQMTLLFFSFVLISLGAGGVRPCSLAFGADQLDRRDNPKNVRVLESFFGWYYASAAISVLIALTGIVYIQDQFGYRVGFGVPAILMLLSALVFFLASPFYLKQQASKSLLTGFVQVIIVAYKNRNLTFPLPNSTASYHHKRDSNVVAPTDKLRFLNKACIIKNPEQDIALDGSAANPWSLCTVEQVEELKALIKVLPLWSTGIIMSINLSQNSFPVLQASSMDRHLTKKFQIPAGSYGMFNIISLALWVIFYDRAILPMASKIKGKPVRIGVKLRMGIGLFLTCIAMVVSAIVENARRKEAIRSGFQNNPTAVVKMSAMWLVPQFCLNGFAEAFTAIGQTEFFYSELPKSMSSIAAALFGLGLAVANVLASVVVSIIDDITSKGGKESWVSSNINKGRIDNYYWVLAILSFINLFYYFLCAWAYGPTGRQATKVKSIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3K8</accession>
    <name>A0A0D2S3K8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G154900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3K8"/>
    <dbReference type="STRING" id="29730.A0A0D2S3K8"/>
    <dbReference type="Gramene" id="KJB77721">
        <property type="protein sequence ID" value="KJB77721"/>
        <property type="gene ID" value="B456_012G154900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77722">
        <property type="protein sequence ID" value="KJB77722"/>
        <property type="gene ID" value="B456_012G154900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779585"/>
    <dbReference type="eggNOG" id="KOG0691">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FREWVGE"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB77722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="338" mass="38172" checksum="EABD54C6C2E23284" modified="2015-04-29" version="1">MEKDTSYYDILGVDVDASIPQIKKAYYLKARRVHPDKNPDDPKAADKFHALGEAYQVLTDPEKREAYDKRGKTRVIPDTMLDPTAVFGMLFGSDFFEDYVGQLAMATLSAIEVESNSLLDKEAHRKKLEENMQAFQKQREDKLIEILKNRLQPFVEGHTNEFIQWANSEARDLSKAAFGEAMLHTIGYIYTRKAARELGKDGSCMQVPFLAEWVRDKGHHIKSQVKAASGAVSLIQIQDELRRLTQGADREENILKALEEKKDAMLQSLWQINVVDIESTLSNVCLEVLRDASVSEEVLVLRAKGMKKLGTIFQGAKSAYSRENSLRRVNVETETAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S5E7</accession>
    <name>A0A0D2S5E7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF829 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G210900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S5E7"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="MORN"/>
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        <property type="entry name" value="HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7_9 FAMILY PROTEIN"/>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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    </reference>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
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    <reference evidence="20" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
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    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. RAD16 subfamily.</text>
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        <property type="protein sequence ID" value="KJB38321"/>
        <property type="gene ID" value="B456_006G248800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800604"/>
    <dbReference type="eggNOG" id="KOG1001">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTSHCRW"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000089">
        <property type="entry name" value="DNA repair protein RAD5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="506"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="875"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="945"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="539"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB38321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="MBA0588678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1112" mass="126265" checksum="62E2E043F2E00879" modified="2015-04-29" version="1">MKAMDIDTVEDKKIQEIQSSMDNNVVSVVKLLPNDPDSNLHANTVSRMVTATGFRVSTLTGSGDQFGESEPVQAIVKEEPLLRLKEEPGLGFDSDASMKEDKVTKVKEEPCLGFGNEVRVKGEMGFNQTEEAVAQKEDSWPMDTFEEFLLLQNSKVQSLNESRKTQIKKKASETAELKSNNQNPPCVKKEPDFEWSQKRVDVKKEVSQERKVNGVLVEDEDFPEDPDWYLVGRTIVNAVSTTKGKNKLLDNEIVYFTFPSPVASYKLQSIVRFSTKRCGEIGRLPMDWAKWVNPLVYSNKVKVLGRCIAAPTTLSIMQEVMLFVSFYIHSSVFTMGDKSSSMFDAPWNMESMLSPLLNLFRYLKIKPYQKADFTPEELNSGKRVLHIQEDGYSEVTAALPAAKRRRGCQEQNKDEQDISEASLNKIVGAADTYDLEEMEPPHTLMCKLRPYQKQALYWMSGWEKGIDAEKAAQTLHPCWSAYRICDERASSIYVNVFSGEATVQFPSARQMARGGILADAMGLGKTVMTIALILSRLGRGNPDNEKPDSRKADGSITTNKKRDTYGSGPRRAKGGTLIICPMALLSQWKDELETHSRPETISIFVHYGGDRTNDPRVISEHDVVLTTYGVLTAAYKSDAENSIYHRVDWYRVVLDEAHTIKSSKTLGARACFALSAHCRWCLTGTPIQNNLEDLYSLLCFLHVEPWCNWAWWKTKIQGPYENGNPTGLKWIKAILRLLMLRRTKETKDKEGRPILVLPPTDIQVIECEQSEAERDFYDALFKRSKVQFDQFVAQGRVLHNYASILELLLRLRQCCNHPFLVMSRADSQQYSDLNKLAKRFLEAHPGLVTLNQNAPTKAYIEEVVDGIRRGENTECPICMESADDPVLTPCAHRMCRECLLSSWRTPTLGSCPICRTLLKKTDLITCPTENKFRVDIDKNWKESSKVSKLLDCLERSCQSGSGEKSIVFSQWTSFLDLLEIPLKRKGIGFLRFDGKLAQKQRERVLKEFNDTREKLVLLMSLKAGGVGLNLTAASNVFLMDPWWNPAVEEQAIMRIHRIGQKRTVTVRRFIVKETVEERMQQVQARKEKMIAGALTDEEVRSARIEELKMLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S9I2</accession>
    <name>A0A0D2S9I2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G085000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S9I2"/>
    <dbReference type="STRING" id="29730.A0A0D2S9I2"/>
    <dbReference type="Gramene" id="KJB40959">
        <property type="protein sequence ID" value="KJB40959"/>
        <property type="gene ID" value="B456_007G085000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0084">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEYQENT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB40959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="101" mass="11712" checksum="69E0A4269603521D" modified="2015-04-29" version="1" fragment="single">KIRTVEQDGKTIKLQIWDTAGQERFRTITSNYYRGAHGIIVVYDVTDQESFNNVKQWLNEIDRYASDNVNKLLVGNKCDLTENKVVSYEIAKVYVMFGCEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SB94</accession>
    <name>A0A0D2SB94_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G108100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SB94"/>
    <dbReference type="Gramene" id="KJB41519">
        <property type="protein sequence ID" value="KJB41519"/>
        <property type="gene ID" value="B456_007G108100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB41519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="64" mass="7441" checksum="6FD508C4F7F91438" modified="2015-04-29" version="1">MNNPNSFHFQNGSSIICLITKSSRMGKYRSDFLIIHRNKRLPTNGPQILQITIRSHTHNLKSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBH2</accession>
    <name>A0A0D2SBH2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G112500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBH2"/>
    <dbReference type="STRING" id="29730.A0A0D2SBH2"/>
    <dbReference type="Gramene" id="KJB41619">
        <property type="protein sequence ID" value="KJB41619"/>
        <property type="gene ID" value="B456_007G112500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802842"/>
    <dbReference type="eggNOG" id="ENOG502QSBA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMMVDNE"/>
    <dbReference type="OrthoDB" id="1891465at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000003">
        <property type="entry name" value="NAC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF221">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 43-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="15"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB41619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="377" mass="42973" checksum="F2ACC291A802DE32" modified="2015-04-29" version="1">MPENMSISVNGQSQVPPGFRFHPTEEELLQYYLRKKVSYEKIDLDVIRDVDLNKLEPWDIQESCKIGTTPQNDWYFFSHKDKKYPTGTRTNRATAAGFWKATGRDKVIYSNCRRIGMRKTLVFYKGRAPHGQKSDWIMHEYRLDDNIVETTVSNAMGEGTQEEGWVVCRIFKKKNHHKTLDNPNSSSLGSESRNHMLSACNEGELEQILEHMRRNCNEEGVANNSWRLMRPIETAISNSYPDSFMKLPSLESPNSTSSQNCYQPMMVDNEGSITNQVSGDPNSRLTNWAALDRLVASQLNGQTETSRQLACFNDHSISMGYGNPSADHHHHDLQSPALRYNRSYNGTQDYNSEMDLWSLTRSSSSSDPLCHVVNASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLT9</accession>
    <name>A0A0D2SLT9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G173600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB42906">
        <property type="protein sequence ID" value="KJB42906"/>
        <property type="gene ID" value="B456_007G173600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:plasmodesma"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:protein serine/threonine kinase activity"/>
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    </dbReference>
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        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
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    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003">
        <property type="entry name" value="OS07G0166700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27003:SF278">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN KINASE ANXUR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="105"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="405" mass="45343" checksum="78420A8E34D42845" modified="2015-04-29" version="1">MFLSLTLNNKEKGAQQPPSINSQNPGSNFFNNLLHFFLILLFDRPFSSEKKTQTSSMSLLHLFQVSKKAFGFVSRQESQPNSTLPEELCIRQFSLAEIKASTANFDEGFIIGISNFGSVYKGVIDDGTFTVAIRRMKFSLSAFRTEVVFLSQLNHLNVESLIGFCNEKGETILVYEYLSNGSLFDCLHGNGISCNPIAWEKRLQICIGAARGLHYLHTGVKYIVLHRNVTSNTILLDHELVPKLSGFFLSRLGPHSMSNASSKKQSLDVMATFGYLYSENLLGKNDVYAFGVVLLEVICGKTPVFEANGQERSLAAWANWCFKNGTIYHNIDPYLKGRVAPECFNKYVEIAMSCISYSADERPSMGEVESTLQDALELQKKADSEMKSIIPHSEVMYEDEQFCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMH6</accession>
    <name>A0A0D2SMH6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">small monomeric GTPase</fullName>
            <ecNumber evidence="3">3.6.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_007G304600</name>
        <name evidence="20" type="ORF">Gorai_019835</name>
    </gene>
    <organism evidence="19 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="20 22" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="20">8</strain>
            <tissue evidence="20">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Small GTPase that cycles between an active GTP-bound and an inactive GDP-bound state and mainly functions in vesicle-mediated endoplasmic reticulum (ER) to Golgi transport. The active GTP-bound form inserts into the endoplasmic reticulum membrane where it recruits the remainder of the coat protein complex II/COPII. The coat protein complex II assembling and polymerizing on endoplasmic reticulum membrane is responsible for both the sorting of cargos and the deformation and budding of membranes into vesicles destined to the Golgi.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Golgi apparatus</location>
            <location evidence="11">Golgi stack membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.2" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMH6"/>
    <dbReference type="SMR" id="A0A0D2SMH6"/>
    <dbReference type="STRING" id="29730.A0A0D2SMH6"/>
    <dbReference type="Gramene" id="KJB45409">
        <property type="protein sequence ID" value="KJB45409"/>
        <property type="gene ID" value="B456_007G304600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761103"/>
    <dbReference type="eggNOG" id="KOG0077">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DWLYNGF"/>
    <dbReference type="OrthoDB" id="964856at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003925">
        <property type="term" value="F:G protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000261">
        <property type="entry name" value="GTP-binding protein SAR1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 18" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
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                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQ62"/>
    <dbReference type="STRING" id="29730.A0A0D2SQ62"/>
    <dbReference type="Gramene" id="KJB33385">
        <property type="protein sequence ID" value="KJB33385"/>
        <property type="gene ID" value="B456_006G008800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTIX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THKHDQA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010017">
        <property type="term" value="P:red or far-red light signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11445">
        <property type="entry name" value="bHLH_AtPIF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000004">
        <property type="entry name" value="Basic helix-loop-helix transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047265">
        <property type="entry name" value="PIF1-like_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044273">
        <property type="entry name" value="PIF3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46807:SF7">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46807">
        <property type="entry name" value="TRANSCRIPTION FACTOR PIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="184"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="353" mass="39960" checksum="CA8FD0C74D18CAA1" modified="2015-04-29" version="1">MSFKASICLAMNHCSSDWNFESDLPISNQKKLLDNELVELLWQNGKVVLQSQTHKKQDDETVSWIQHPFEESFEKEMFSNFFSEFPVYDPMDHQHEQQEDDKNLSRGSSNGIGTTSTGLSVGTSKDDEDDDNGGQVENEKGTSGGVTSSQKRKNRDGREDYECQCEFAEVKPVRRSGSCRRQSRAAEVHNLSERRRRDRINEKMRALQELIPHCNKTDKASMLDEAIEYLKSLQLQLQVMWMGNGMAPMMFPGIQHYMSPMAMGTAPPTMPSIQNQRFIQNPTFSEQYARFLGFHHMQTASQPINMFGYGSQTTPQSPTVLGFSNGSNPLNGGTTATNNTSLSGKIVLWRLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRT1</accession>
    <name>A0A0D2SRT1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G071800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRT1"/>
    <dbReference type="Gramene" id="KJB46794">
        <property type="protein sequence ID" value="KJB46794"/>
        <property type="gene ID" value="B456_008G071800"/>
    </dbReference>
    <dbReference type="OMA" id="DFQDDWA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB46794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="67" mass="7812" checksum="5F7966A8CA6FA832" modified="2015-04-29" version="1">MGKLYHVLLNHFLNHLRCLFDPVAIYSKTTAFHGLGVCSLVLFSPYMRKGNRFKTNNHVLDFQDDWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ST06</accession>
    <name>A0A0D2ST06_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_010G142100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ST06"/>
    <dbReference type="STRING" id="29730.A0A0D2ST06"/>
    <dbReference type="Gramene" id="KJB66508">
        <property type="protein sequence ID" value="KJB66508"/>
        <property type="gene ID" value="B456_010G142100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FPCTAVI"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050262">
        <property type="entry name" value="Ribose-5P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43748:SF1">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
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                <person name="Duke M.V."/>
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                <person name="Grimwood J."/>
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                <person name="Lee T.H."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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                <person name="Saranga Y."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:regulation of flower development"/>
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        <property type="entry name" value="CCT MOTIF FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="247"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="PROSITE" id="PS51017"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB37520.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="343" mass="38539" checksum="2871205B2AF35DC6" modified="2015-04-29" version="1">MSQTQDLSLSPSSTSNFIQMSYNLSVSDNSSFNRCIPEMVSTDTIDFDSLFNLPFYDSSFDYNLQALSNNDDNQLNPVDESPPADQLLADLLPSNQLENLSLCQTTQFPSLSFGSHSENPGGSSRLEVKNEECRVDFDSAYGGVHENAGKYLQRSFSSNCFEGKSNFSFKPPFDSLMESQSFQGQASSLPETSFFTAQMRKVSSTGDLQSMRNVHNTQRSISTPCAMENTFMEESGFKVGRYNAEERQERISKYRAKRSQRNFNKTIKYACRKTLADTRPRIRGRFARNDETVETPKLACSTGDEADDLWGLLHEVGDEATATSGTLMNNFGQYQFQFNHGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T4Q4</accession>
    <name>A0A0D2T4Q4_GOSRA</name>
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            <fullName evidence="13">Malectin-like domain-containing protein</fullName>
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        <name evidence="15" type="ORF">Gorai_009402</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2T4Q4"/>
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        <property type="gene ID" value="B456_008G120500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB49467">
        <property type="protein sequence ID" value="KJB49467"/>
        <property type="gene ID" value="B456_008G120500"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="735844at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004714">
        <property type="term" value="F:transmembrane receptor protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000001">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045272">
        <property type="entry name" value="ANXUR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590">
        <property type="entry name" value="OS03G0124300 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34590:SF6">
        <property type="entry name" value="RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395495" description="Malectin-like domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin-like" evidence="13">
        <location>
            <begin position="46"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB49466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0592420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="473" mass="52697" checksum="5B92EDCBE9A868AB" modified="2015-04-29" version="1">MGTLLSSHGFSLFLLWTFTLYGLCLSFSPIDNYLINSGASLDSVVDNRRFISDSSNSPDSHLSSGRTFSLCAGTLLPGLPQIYHTARVFNSPSKYVFNVKDPGTHMVRLHFHRFNSSRLDLGNSRFHVLVNGLVALTNFSGGDFVNPKVIEYLLCVNSEKVEIRFVPAKKSNFAFVNAIEVISAPKDLVLETAQYVNGDKIEEFQGLNKQAFETMYRVTVGGPKVTPFNDSLWRTWIPDDEYLKLSEGSNKVYFGGRIKYQDGGASREVGPDNVYDSARLIRSKNASIPNVNLTWEFPVSEDYKYLVRMHFCDIASISLGLLYFNVYVNEHLAYKDLDLSDVTNYMLASPFYADFVVDAGRSGVITVSVGPSSKSMGYTVDAILNGVEIMKMNNSVYSLAGKVPAELIMKCWPRRTLGILLPLIALACLLLSLSAIVHRRKSNAELFPWSKLPTDIHEISPKQAKLQLSNIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5H9</accession>
    <name>A0A0D2T5H9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Plasma membrane proteolipid 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G134100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5H9"/>
    <dbReference type="STRING" id="29730.A0A0D2T5H9"/>
    <dbReference type="Gramene" id="KJB49701">
        <property type="protein sequence ID" value="KJB49701"/>
        <property type="gene ID" value="B456_008G134100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF120">
        <property type="entry name" value="HYDROPHOBIC PROTEIN LTI6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB49701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8576" checksum="FF64F5AD2C31E4AC" modified="2015-04-29" version="1">MPSINMCICIKCGCFSCKNTSGERDEKAGAADCVDIMLAILLPPAGIYKKEGCTGRFWANVVLTVLGIAPGSIHAVICISGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7Q2</accession>
    <name>A0A0D2T7Q2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_011G138200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T7Q2"/>
    <dbReference type="Gramene" id="KJB71708">
        <property type="protein sequence ID" value="KJB71708"/>
        <property type="gene ID" value="B456_011G138200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WLWDTIS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051502">
        <property type="entry name" value="RLP_Defense_Trigger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062:SF37">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251889" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="931"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB71708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="989" mass="111188" checksum="D17F669A0844EE91" modified="2015-04-29" version="1">MGPTWLRLLLISVLALEGAVWSDGCWDEERVALLQLQHFLTDIEYSREGPDCCEWKWVDCNITTRRVIQLSSLWGRLKIKDSNLFNASMFLPFEELKSLDLSGNDLVGCVENEAPLKWLSKLGGLETLDLSITNAKNNLLLHLGGLSSLITLILQQNDLKETIHLRGNDGQLSLINLEEIDLTVNLFNNSIMEELSGFSNLKSLKIGSNRLNGLVDLKELCALGHLETLDLSYNEVNRFVTSKGLCYLNNLEELSLNGNALGGAVAPCLGNLTSLRYLDISNNHFTGNIASTPLANLTTLQFLSLSNNQLQVPMSFRSFANHSNLKVLLADQNNMVADEPTAFQTWWPKFQLEVFSMSNCMIEEHGNLQLPNFLYFQHDLRDVDLSYCDFGGIRFPHWLLENNTRLEQLYMIDTSIVGPLFLPSHPSFNLKVFDISNNKIHHDIPRNFCSLFPHLEGLFMSKNDFKTDIPPCLGGLRRLQMLDLSHNDLFGEIPEELRMSSSLANLILSNNSLSGKIIPTVYHLIILLEELRLDGDKFEGEISYFSPISIKNLQVLDVSDNDISGELPTWLWDTISLKILDFSKNNFEGPITMQLCKLINLEFLDLSSNHLSGTIPSCSNLQRMRHVHLANNRLSGTLSNVIFKSSPLVTLDLSGNSFTGRIPNWISTLPILSVLLLKENQFDGEFPLQLCKLQSLSILDFSHNKLSGHLPSCLSNLTLKPSEKSYVDSGGYQFDFFDDVMVHMGLTIYNLTGLVSVYRGYPFTYHEEDVLFSTKGATYTYKGNILDLLSAIDLSCNQLTGIILPGFGNLSEIRGLNLSHNNLTGPIPSTFSELKQIESLDLSYNNLSGRIPSELTEMTSLEVFSVAHNNLSGPLPDRKNQFGTFDESNYEGNPLLCGPPLNKSCNGGNSPTAPNATSSEEEHGHIDMVDFYISFATSYAIIFLTTILVLYINPYWRRACFYFIEDRSIVCYFFIVDSLRQLPCFRRNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T828</accession>
    <name>A0A0D2T828_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G030800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T828"/>
    <dbReference type="STRING" id="29730.A0A0D2T828"/>
    <dbReference type="Gramene" id="KJB39790">
        <property type="protein sequence ID" value="KJB39790"/>
        <property type="gene ID" value="B456_007G030800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801984"/>
    <dbReference type="eggNOG" id="KOG1100">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1170.10:FF:000002">
        <property type="entry name" value="Baculoviral IAP repeat containing 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000239">
        <property type="entry name" value="probable BOI-related E3 ubiquitin-protein ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42647:SF5">
        <property type="entry name" value="SBP (S-RIBONUCLEASE BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036836">
        <property type="entry name" value="RNase_bind_SBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="182"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB39790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="38070" checksum="80FAD42BAAD866A0" modified="2015-04-29" version="1">MAVQAQYPSNVLLLNRSGQEGNEFPLQQQAGGVFLDQSHSHMLLNNNNNNPRKRGREVAGAAITAPINSYSMQTQPPQLIELSQLHHPNVVSTGLRLSFGDQQQKLQQHQNQNQNQSYRQQQQQQQNLVSNSSVFASDDLVTQIKRQRDELDHFLQAQGEELRRTLAEKRHRHYRALLEAAEESVARRFREKEAEVEKAKRRNVELEARAAQLGAEVQVWQAKAKAQEVTAASLQAQLQQAIMNGGAGLTQQDSRRGGEEWRKCAGGESEAQAEDAESAYVDPERVVAAASGPCCKACRTRVAAVVLLPCRHLCLCTECDRVAQACPLCLTLRNSSVEVFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TBW8</accession>
    <name>A0A0D2TBW8_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G223400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB73223">
        <property type="protein sequence ID" value="KJB73223"/>
        <property type="gene ID" value="B456_011G223400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB73223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="11775" checksum="12EFD750E664FF17" modified="2015-04-29" version="1">MCYPKCLVQDVISFYSLPSPMSEYLKMYKIGNTIISCWFVKPSLSRKSCLVAQSSTLALSMCLSLSHPRTYVSMSLQIRILQTDITLLSTHAIYLDFYLCFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TFH9</accession>
    <name>A0A0D2TFH9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G075500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TFH9"/>
    <dbReference type="STRING" id="29730.A0A0D2TFH9"/>
    <dbReference type="MEROPS" id="A22.A15"/>
    <dbReference type="Gramene" id="KJB55419">
        <property type="protein sequence ID" value="KJB55419"/>
        <property type="gene ID" value="B456_009G075500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770006"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYFKTKS"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB55419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="341" mass="37763" checksum="49FC16FC1E87D267" modified="2015-04-29" version="1">MKNTERLANLALAGLTLAPLVMKVDPNLNVILTACLAVYVGCYRSVKPTPPSETMSKEHAMRFPFVGSAMLLSLFLLFKFLSKDLVNAVLTCYFFVLGIIALSATILPALKHFLPKHWNEDHIIWRFPFFRSFEIEFTRSQIIAAIPGTFFCAWYASQKHWLANNILGLAFCIQGIEMLSLGSFKTGAILLAGLFVYDIFWVFFTPVMVSVAKSFDAPIKLLFPTADSARPFSMLGLGDIVIPGIFVALALRFDVSRGKGSQYFKSAFLGYTVGLVLTIVVMNWFQAAQPALLYIVPAVIGFLAAHCVWNGDVKPLLEFDELKTAVTSEDGSDDKSSKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TLY9</accession>
    <name>A0A0D2TLY9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G087300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TLY9"/>
    <dbReference type="STRING" id="29730.A0A0D2TLY9"/>
    <dbReference type="Gramene" id="KJB55651">
        <property type="protein sequence ID" value="KJB55651"/>
        <property type="gene ID" value="B456_009G087300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770450"/>
    <dbReference type="eggNOG" id="KOG3449">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF115">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB55651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="113" mass="11362" checksum="55B3DEEFA991A32D" modified="2015-04-29" version="1">MKVVAAYLLAVLGGNLSPSADDLKDILGSVGAEADDDRIELLLSEVKGKDITELIATGREKLASVPSGGGAVAAAPTAGGGGASAAPAAEAKKEEKVEEKEESDDDMGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQN8</accession>
    <name>A0A0D2TQN8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G154000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQN8"/>
    <dbReference type="STRING" id="29730.A0A0D2TQN8"/>
    <dbReference type="Gramene" id="KJB57216">
        <property type="protein sequence ID" value="KJB57216"/>
        <property type="gene ID" value="B456_009G154000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57217">
        <property type="protein sequence ID" value="KJB57217"/>
        <property type="gene ID" value="B456_009G154000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767963"/>
    <dbReference type="eggNOG" id="ENOG502QTRT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYAPRLE"/>
    <dbReference type="OrthoDB" id="660108at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044809">
        <property type="entry name" value="AUF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31215">
        <property type="entry name" value="OS05G0510400 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="20"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB57216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="391" mass="42135" checksum="0873AC6F2A669098" modified="2015-04-29" version="1">MSSVYSDPIHGTHPEPIDHFDRLPDSLLLLVFNMIGDVKALGRCCVVSRRFHALVPQVENVVVRVDCVISDDDCSPSSSVKSRAAGPFSTLFRLVFGGIVKPLQALGQFLGPERPSLNKTLNTSSSSSLSVGLGGGEDGEMDQGGVTHHSPTQVLRNFNELRFLRIELPGGELGIDDGVLLKWRADFGSTLDSCVILGAASVFNNVHFQVPGHGNDGFCINNGSNVGNGDDNGSIPESFYTNGGLKLRVVWTISSLIAASARHYLLQSIIAEHKTLDSLVLTDADGQGVLCMNGEQLEELRVKPLSASAASKRTLVPALNMRLWYAPHLELPDGVVLQGATLVAIRPSEQSASKKEVSDASWLSSAFEEPYGTAAKMLVKRRTYCLEMNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSD0</accession>
    <name>A0A0D2TSD0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G000700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSD0"/>
    <dbReference type="Gramene" id="KJB78473">
        <property type="protein sequence ID" value="KJB78473"/>
        <property type="gene ID" value="B456_013G000700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781108"/>
    <dbReference type="eggNOG" id="KOG2381">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQHHGFR"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF21">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="108"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="540" mass="59121" checksum="9583BBB7D9A5DF6A" modified="2015-04-29" version="1">MSFFTMAVAVDQHHGFKPFNRSQRCRLQSFTQLEYNILEVGHKDLAHSLKQVFEVANFHRSFSTPCLSFATNVEQEYATHPRIQIIGGPRLPRINALVIEVAMAIASGVVPVPVSNGLGGTYFLRNRRGETIAVTKPIDEEPLALNNPKGCGGSMLGQPGINRSIRVGETGIRELAAYLLDHGGFAGVPATALVKISHVAFHVNEATAISASPYKIASLQNFISHDFDAGNLGSSCFSVASVHKIGIFDLRILNLDRHAGNILVKKRGQHENFAVEAAELVPIDHGLCLPECLDDPYFEWLHWPQALVPFSESETEYILNLDPNKDAEILRTELPLLRESSIRVLILCTIFLKQAVSAGLCLADIGAMMTRELRGDEEKMSMLETLCVKAKESISEVDDGMDRYEVDDTGIFLVDNDIEGTSNEIAADIPKLFQNPLNLAKPPRPSKLSSVRLMPCASLPPLYKDTEVHIENGAKSNGKAAVGTVQGMSFSVQNGSGGGGVNLGDMRESKWEMFLESFVKLLPQAFDGSSKLKLRTSCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TX98</accession>
    <name>A0A0D2TX98_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G077900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TX98"/>
    <dbReference type="STRING" id="29730.A0A0D2TX98"/>
    <dbReference type="Gramene" id="KJB80038">
        <property type="protein sequence ID" value="KJB80038"/>
        <property type="gene ID" value="B456_013G077900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80040">
        <property type="protein sequence ID" value="KJB80040"/>
        <property type="gene ID" value="B456_013G077900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782853"/>
    <dbReference type="eggNOG" id="ENOG502QVCZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTNDEMN"/>
    <dbReference type="OrthoDB" id="1918650at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36034">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36034:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="852" mass="92342" checksum="C863F5EA15FBEB29" modified="2015-04-29" version="1">MNFLLLRSNQQAVPEPPPVQEEVAESTYVSSSATSLEGLIGEDPFPEYPTVENHDAETNGHLGDNAGVGSGKKSSVPENHIDVCEEDGWITIPYRDLPDDWNCAPDISSLRSLDRSFVFPGEQVHVLACLSACNQETEIITPFKVAAVMCKSGKRRGAQKQNGNMEGETNSVPEGGDASLNGAVMDQNGENLEKDKIDPAKDVSASESFLRMEDHRRQTETLLKRFKNSHFFVRIAESGEPLWSKKGASEKVSELSEMDSQQSIANETNNAAKNISRQNAVIDRGNFDANVSGGVARDSIKCCSLSSGDIVVLLKVNVGVDFLRDPVIEILQFEKYQDRNPSSKNQDNLVYANQDPCGELLKWLLPLDNTLPTPLTLSPPPLGSASGIGSPSQRPGVSASSGSPLFSFSHFRSYSMSSLPQNVTPPAGPVKAQSSKPSFDLDDVDHYTSQKNSKGKITGIEELLSYRGVSLERERFSVRCGLEGIHIPGRRWRRKLQIIQPIEIHSYAADCNTDDLLCVQIKNISPENVPDIVVFVDAITVVLEEASKGGPPASLPISCIEAGDDHSLPNLALRRGEEHSFILKPVSSMWKDLKTHGEKSKSSALQPPSMTSDRKGSVLVVNHYAVMVSCRCNYTESRLFFKQPTSWRPRVSRDVMISVASEMSGQYSGPNEGITQLPVQVLTLQASNLSDEDLTMTVLAPTSLTSPPSVVSLNSSPATPMSPFVGFSELAGKAGGERRTTAVSMPSLSENQKQNGDAGAKFTSSNAQLTPTADFIPTSGLGCTHLWLQSRVPLGCVPAQSTATIKLELLPLTDGIITLDTLQIYVKEKGLTYIPEHSLMINATSSISTGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXL0</accession>
    <name>A0A0D2TXL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">allantoate deiminase</fullName>
            <ecNumber evidence="12">3.5.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_008G050700</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>allantoate + H2O + 2 H(+) = (S)-2-ureidoglycine + NH4(+) + CO2</text>
            <dbReference type="Rhea" id="RHEA:27485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:59947"/>
            <dbReference type="EC" id="3.5.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.3.9" evidence="12"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXL0"/>
    <dbReference type="STRING" id="29730.A0A0D2TXL0"/>
    <dbReference type="MEROPS" id="M20.A07"/>
    <dbReference type="Gramene" id="KJB48025">
        <property type="protein sequence ID" value="KJB48025"/>
        <property type="gene ID" value="B456_008G050700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763083"/>
    <dbReference type="eggNOG" id="ENOG502QSJ5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047652">
        <property type="term" value="F:allantoate deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000019">
        <property type="entry name" value="Allantoate deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF19">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252151" description="allantoate deiminase" evidence="13">
        <location>
            <begin position="33"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="14">
        <location>
            <begin position="260"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB48025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="482" mass="52120" checksum="65DB0DC94EF47DE9" modified="2015-04-29" version="1">MTFTRISHFSLFFSSFFFLSSTLSSHLYPASATTPEKDGKTRSLYSEILRDEAVARLNDLGKVSDADGYLERTFMSPASVRAGFLIREWMEDAGLRTWVDSMGNLHGRVEGMNASAQALLIGSHLDTVVDAGMFDGSLGIISAISALKVLKSIGKLGELKRPVEVIAFSDEEGVRFQSTFLGSAAVAGILPVTALKISDKSGVTVQDALKGNSIEITEDSLLGLKYDPASIWGYFELHIEQGPVLEWVGFPLAVVKGIAGQTRMKVTVRGSQGHAGTVPMSMRRDPMAAAAELIVLLESLCKHPRDFLSSGGNCNEQTLESLSTSLVCTVGEISTWPSASNVIPGQVTFTVDLRAIDDVGREAVVYELSNQMYKICDRRSVSCIIERKHDANAVICDQELSSRLKSAAYSAVNKMVGQIHEEVPVLMSGAGHDAMAISHLTKVGMLFVRCRGGISHSPEEHVLEDDVWAAGLAVLAFLESHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U000</accession>
    <name>A0A0D2U000_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VPS37 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G411000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U000"/>
    <dbReference type="SMR" id="A0A0D2U000"/>
    <dbReference type="STRING" id="29730.A0A0D2U000"/>
    <dbReference type="Gramene" id="KJB62314">
        <property type="protein sequence ID" value="KJB62314"/>
        <property type="gene ID" value="B456_009G411000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767758"/>
    <dbReference type="eggNOG" id="KOG3270">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNEVFHS"/>
    <dbReference type="OrthoDB" id="10260857at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13678:SF2">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="9">
        <location>
            <begin position="151"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="140"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB62314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="230" mass="26451" checksum="4AB84E06D0674375" modified="2015-04-29" version="1">MFRFWGSQEQQAQPHPQEDSSHSWYPPPGVSSTNSSRPSTPGSSASNSFNLQRPSERPHSPSQVSPSEAAGIIALLKDKSVDELRKLLSDKDAYNQFLLSVDQVKIQNNIRDELRKETLQLARNNLDKEPQIMELRNQCRIIWTTELAAALEKLNDLERQKEEILKFYSPASFINRLQDAMNETDKESEMVNRQLLEKEIDLGTFVQKYKKLRTSYHRRALIHLAAKTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U270</accession>
    <name>A0A0D2U270_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Uridine kinase</fullName>
            <ecNumber evidence="12">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G452400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the UPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the uridine kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="12"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U270"/>
    <dbReference type="STRING" id="29730.A0A0D2U270"/>
    <dbReference type="Gramene" id="KJB63044">
        <property type="protein sequence ID" value="KJB63044"/>
        <property type="gene ID" value="B456_009G452400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB63047">
        <property type="protein sequence ID" value="KJB63047"/>
        <property type="gene ID" value="B456_009G452400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768597"/>
    <dbReference type="eggNOG" id="KOG4203">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000904">
        <property type="term" value="P:regulation of starch metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000015">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="13">
        <location>
            <begin position="49"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="265"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB63044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="482" mass="54150" checksum="7760176DAA3EA3F0" modified="2015-04-29" version="1">MGSAAVEDMIEASSGVHFSGFHMDGLDSRHIKKPMISPATENMHNQPFLIGVAGGAASGKTTVCDMIIQQLHDQRVVLVNQDSFYHKLTEEELARVHEYNFDHPDAFDTEKLLDSIDNLRHGRAVDIPKYDFKSYKLDVFPVRRVNPSDVIILEGILIFHDPRVRELMNMKIFVDTDADVRLARRITRDTVGKSRDIGAVLDQYSKFVKPAFDDFILPTKKYADIIIPRGGDNHVAIDLIVQHIRTKLGQHDLCKIYPNLYVIQSTFQIRGMHTLIRDSQTTKHDFVFYADRLIRLVVEHGLGHLPFTEKQVITPTGSVYTGVDFCKRLCGVSIIRSGESMENALRACCKGIKIGKILIHREGDNGQQLIYEKLPQDISKRHVLLLDPILGTGNSAVQAISLLIKKGVPESNIIFLNLISAPQGVHMVCKSFPRLKIVTSEIDIGLNKDFCVIPGMGEFGDRYFGTDDDDDQKVVTPMQQSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U289</accession>
    <name>A0A0D2U289_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIN4 pathogenic type III effector avirulence factor Avr cleavage site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G451800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB63074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U289"/>
    <dbReference type="STRING" id="29730.A0A0D2U289"/>
    <dbReference type="Gramene" id="KJB63074">
        <property type="protein sequence ID" value="KJB63074"/>
        <property type="gene ID" value="B456_009G451800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768588"/>
    <dbReference type="eggNOG" id="ENOG502S4YA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFCCLQA"/>
    <dbReference type="OrthoDB" id="1903947at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040387">
        <property type="entry name" value="RIN4/NOI4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF93">
        <property type="entry name" value="PROTEIN NOI4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB63074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8350" checksum="0258A98E8F45C889" modified="2015-04-29" version="1">MSEDKGRPLPKFGEWDVNDPASAEGFTVIFNKARDEKKTGGKPESPAKADAHGKPGADPSKPQSKKWLCCVQAPPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U6R9</accession>
    <name>A0A0D2U6R9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G055400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB64509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB64509"/>
        <property type="gene ID" value="B456_010G055400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S71B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121">
        <property type="entry name" value="HOMEODOMAIN PROTEIN 8, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB64509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="110" mass="12253" checksum="22DBA658E8185BFF" modified="2015-04-29" version="1">MAAEMMLRCVFEGSISMQDCLIERRPYHRNCQCALHNLKGVCLSTCTSRTTNMSFPKKQTWGDCSLCLSASKFSAQSPLLPDASFTNTIQNIDAAPVLSETEAQHSQVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAC2</accession>
    <name>A0A0D2UAC2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Dof zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G267000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Transcription factor that binds specifically to a 5'-AA[AG]G-3' consensus core sequence.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAC2"/>
    <dbReference type="STRING" id="29730.A0A0D2UAC2"/>
    <dbReference type="Gramene" id="KJB52540">
        <property type="protein sequence ID" value="KJB52540"/>
        <property type="gene ID" value="B456_008G267000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765430"/>
    <dbReference type="eggNOG" id="ENOG502RS8X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GESTGHC"/>
    <dbReference type="OrthoDB" id="1927254at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045174">
        <property type="entry name" value="Dof"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003851">
        <property type="entry name" value="Znf_Dof"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF1.4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31992:SF301">
        <property type="entry name" value="DOF ZINC FINGER PROTEIN DOF3.7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02701">
        <property type="entry name" value="Zn_ribbon_Dof"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01361">
        <property type="entry name" value="ZF_DOF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50884">
        <property type="entry name" value="ZF_DOF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Dof-type" evidence="11">
        <location>
            <begin position="35"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB52540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="217" mass="24075" checksum="270A78E0F1853161" modified="2015-04-29" version="1">MEATQWEQGIGVTKPMAIGEYSRSSARVQKGEANLNCPRCNSTNTKFCYYNNYSLSQPRYFCKTCRRYWTHGGSLRNVPVGGGSRKNKTSSSKKLDDDHLTHQNPKIHEGDHHQVINLAYPPVVPAQAYNSSQRLPFMPEIGGASTGIYSSGFPVLDPGLKFSSDGFGTGYDENHQGVEENGERLLLPVKEESKQVPVNTMNELDEDKEQGESTGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULK3</accession>
    <name>A0A0D2ULK3_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Stigma-specific STIG1-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G180700</name>
    </gene>
    <organism evidence="4 5">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULK3"/>
    <dbReference type="Gramene" id="KJB56845">
        <property type="protein sequence ID" value="KJB56845"/>
        <property type="gene ID" value="B456_009G180700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1NG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEGPDCC"/>
    <dbReference type="OrthoDB" id="5421723at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227:SF32">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252743" description="Stigma-specific STIG1-like protein 1" evidence="3">
        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB56845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14856" checksum="0F2FA845E4984150" modified="2015-04-29" version="1">MKFLNLFFMLSIVMALVAITLSAITSEKSDHPLGNSQMAASFRGAGGFPTQGFRPFLTCDKQPEICSMKGLFCCNRRCVDLKTEQFNCGRCGKTCNYSSICCEGKCVSPLFDENHCGGCNNSCGKGSSCVYGMCNYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2C8</accession>
    <name>A0A0D2V2C8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_012G061100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V2C8"/>
    <dbReference type="STRING" id="29730.A0A0D2V2C8"/>
    <dbReference type="Gramene" id="KJB75851">
        <property type="protein sequence ID" value="KJB75851"/>
        <property type="gene ID" value="B456_012G061100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VCDIFNI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000002">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF30">
        <property type="entry name" value="SUGAR TRANSPORTER SWEET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB75851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="28485" checksum="050BC1D03E82260D" modified="2015-04-29" version="1">MVSADTARTIVGIIVFRILFVMFCFAGNVISFFLFASPLPTFVKIYKKMAVEEFKPDPYIATAMNCMLWIFYGLPMVHPDSILVVTINSIGLAMELIYLSIFFLYAPNKGRAKVIGWLALEILFLGVVAACTLTLRKTHAQRSDLVGILCVIFGVLMYASPLTVMRKVIKTKSVKYMPFYLSLANFLNGVIWVTYALIRFDLYILIGNGLGALSGAIQLILYACYFKSTPKDDDENGVVEPSELQLSGGNGPSRPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3S0</accession>
    <name>A0A0D2V3S0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G009000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2V3S0"/>
    <dbReference type="Gramene" id="KJB63630">
        <property type="protein sequence ID" value="KJB63630"/>
        <property type="gene ID" value="B456_010G009000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772698"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000009">
        <property type="entry name" value="Auxilin-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF84">
        <property type="entry name" value="AUXILIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="1243"/>
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        </location>
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            <begin position="1088"/>
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    <feature type="compositionally biased region" description="Basic residues" evidence="2">
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            <begin position="106"/>
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        </location>
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            <dbReference type="ARBA" id="ARBA00023054"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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            <dbReference type="PROSITE" id="PS50076"/>
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            <dbReference type="EMBL" id="KJB63630.1"/>
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            <dbReference type="Proteomes" id="UP000032304"/>
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    <sequence length="1307" mass="147119" checksum="C6BB6C52926DEF20" modified="2015-04-29" version="1">MEYQRASAATSFSKKLSNGHSFNGKSLYDGVFGGQTKVGSAVEDYAEIFGGGSGSSIPFLDVPELNQRKFSVEVSSSKLDYSNIFGGFGDVDFAVSHEEFVAKPTRDKKRPAKTKSHSEGSFSYPSSNRVVSNDEASHGSSNGVKQFKMSYNKSSLGSKNGTNGTIHVAVPGFTCVVDENIAPPREDPVSSAVNEPYGTEKLGGGKGDDGVHCEKPASDVQACGVGKETLKGVDQFHSEPKSNGSDCNDVLFGTYDFGHGTPPSKVKRASSMSYNNGVNNRDSLKFGVPRSQSLDCDMGVSSPPYFDDELDVNSVAATSAAAVKKAIEEAQARLKVAKEIMERRKGYMGRVKPRSNGSSTSEERKKSKDTVKQNNFREDKAQETSEKIVASQQTSDGVKMQNVIKVHQVAAELEDEKRGFVAREAAGETCAKDFISLQADCRQDEVEKREAAKDGEREKDVTQDLNEHEGEEKTTFDKPEEYNEEPEVVEEATELKKKIDELREFFDNEECLHESVPDVEFHDTKEDETELRFGEQWEETEENVCNELEPCERKSEDPEQPIEDEKKVEMEEVKDTDDLERLTVAKEGLDMEEKHQHKIEQEENVSEKEKNEMLLEDVSVQEKFEEISEEAFEISELKEEVSAACRPEENNEEEDACDREDNEQMSDKMKEPVIIDPRDDAFDHEEEMRKLEENGDSLGNEEFMEAEENVELLEDAYQMEAADEGQMMASESVGTEEVQNQTNQEADEMTEAREDALDCYWEDLKVADNASNSNEINYLGETLEPSISEDSCETTPEFLCNEENEGIVEGCKAYSECKETEINSEADEMATNLEENLEFDKSDLAESNLKPDEIKWQAENTADASNFERSSIDVDPADVTFEKDHYEQHSEKSEKTFTMEKHVEELACKSEDVREAVVCLKQEENKYSFEHTDEVRFVDSQLHCEFGDKNEATQIGHEIEAGQSTEYEEENSPKTLMKEERETENASEEEVKLVREEQKRVDEAKERERKKEKVKEKEKERIAVERAIREARERAFAEARERAAAGRTNIEAQRKVKAETTQGESVKHSADTNDKTFMEAKLKAERAAVERATAEARQRALEKALSEKASLGARNQAEKFSDSKHSYQSYDSRYKGSCPPATSRYPNSSNQSASKYSEESDGAVGESAQRCKARLERHQRTAERAAKALAEKNERDLLAQKEQAERNRLAETLDAEVKRWLSGKQGNLRALLSTLQYILGPDSGWQPISLTDILGTAAVKKAYRKATLCVHPDKLQQRGANIQQKYICEKVFDLLKEAWNRFSAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5R7</accession>
    <name>A0A0D2V5R7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Coatomer subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_012G154500</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJB77746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2V5R7"/>
    <dbReference type="Gramene" id="KJB77746">
        <property type="protein sequence ID" value="KJB77746"/>
        <property type="gene ID" value="B456_012G154500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779715"/>
    <dbReference type="eggNOG" id="KOG0292">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="131"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="244"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="340"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="18">
        <location>
            <begin position="611"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="17">
        <location>
            <begin position="814"/>
            <end position="1216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR003354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB77746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1216" mass="136247" checksum="ACDEFB80940A7590" modified="2015-04-29" version="1">MLTKFETKSNRVKGLSFHTKRPWILASLHSGVIQLWDYRMGTLIDRFDEHDGPVRGVHFHMSQPLFVSGGDDYKIKVWNYKLHRCVFTLLGHLDYIRTVQFHHENPWIVSASDDQTIRIWNWQSRTCISVLTGHNHYVMCASFHPKEDLVVSASLDQTVRVWDIGSLNKKTASPADDILRFSQMNSELFGGVDAVVKYVLEGHDRGVNWAAFHPTLPLIVSGADDRQVKLWRMNETKAWEVDTFRGHMNNVSCVLFHSKLDIIVSNSEDKSIRVWDVTKRTGLQTFRREHDRFWILAVHPEMNVLAAGHDSGMIVFKLERERPAFAVSGESLFYAKDRFLRCYDFSTQREAQVIPIRRPGSASLNQSPRTLSYSPTENAVLICSDVDGGSYELYVIPKDSFGRGEMQEAKKGLGSSAIFVARNRFAVLDKGNNQVLIKNLKNEVVKKSGLPVPTDAIFYAGTGNLLCRSEDRVVIFDLQQRLVLGDLQTPLVKYVVWSNDMENVALLSKHTIVITNKKLVHRCTLHETIRVKSGAWDDNGIFIYSTLNHIKYCLPNGDCGIIRTLEVPIYITKVSGNTIFCLDRDGKNKAIVIDATEYIFKLSLLRKRYDQVMSMIRNSQLCGEAMIAYLQQKGFPEVALHFVKDEKTRFNLALESGNIQIAVASAKEIDDKDHWYRLGVEALRQGNAGIVEYAYQRTKNFERLSFLYLINGNLEKLSKMLKIAEVKNDVMGQFHNALYLGDIKERVKILENAGHLPLAYVTASVHGLQDVADRLAAELGDDVLPLPTGKEPSLLMPPTPVVSGGDWPLLRVMKGIFEGGLDSIGRGGVDEEEGAEGDWGEDLDVVDVDGLQNGDVAAVLEDGEVAEENEEEGGWDLEDLELPPEVETPRVSNNARSSVFVAPTPGMPVSQIWTQRSSLAADHAAAGNFDTAMRLLSRQLGIRNFAPLKSMFLDLHAGSHSYLRALSSAPVVSLAIERGWSESGSPNVRSPPALVFNFSQLDEKLKAGYKATTAGKFTEALRLFLSILHTIPFIVVESRREVDEVKELIIIAKEYVLGMQMELKRREMKDNPVRQQELAAYFTHCNLQLPHLRLALLNAMTVCYKAKNLATAANFARRLLETNPTNENQAKTARQVLQAAERNMTDASQLNYDFRNPFVTCGATYVPIYRGQKDVSCPYCTARFVPSQGGQLCTVCDLAVVGADASGLLCSPSQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V680</accession>
    <name>A0A0D2V680_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bile acid:sodium symporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G168600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V680"/>
    <dbReference type="STRING" id="29730.A0A0D2V680"/>
    <dbReference type="Gramene" id="KJB77936">
        <property type="protein sequence ID" value="KJB77936"/>
        <property type="gene ID" value="B456_012G168600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2718">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFAPQVC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004710">
        <property type="entry name" value="Bilac:Na_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361:SF66">
        <property type="entry name" value="OS12G0170300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10361">
        <property type="entry name" value="SODIUM-BILE ACID COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB77936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11269" checksum="1B020F0D601475E7" modified="2015-04-29" version="1">MPLYGDHVAVILSVMLLHFTGFFVGYISAAICRFREAERRAISIEVGMQNSSLGVVLATTHFTSPVVALPSAMSAVIMNIMGSSLGFFWRQISGSKQELEDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VCL0</accession>
    <name>A0A0D2VCL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CYRIA/CYRIB Rac1 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G119000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2VCL0"/>
    <dbReference type="Gramene" id="KJB80871">
        <property type="protein sequence ID" value="KJB80871"/>
        <property type="gene ID" value="B456_013G119000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782643"/>
    <dbReference type="eggNOG" id="KOG3534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQPNRVE"/>
    <dbReference type="OrthoDB" id="10265867at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009828">
        <property type="entry name" value="CYRIA/CYRIB_Rac1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008081">
        <property type="entry name" value="Cytoplasmic_FMR1-int"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12195">
        <property type="entry name" value="CYTOPLASMIC FMR1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07159">
        <property type="entry name" value="CYRIA-B_Rac1-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05994">
        <property type="entry name" value="FragX_IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008153">
        <property type="entry name" value="FMR1_interacting"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01698">
        <property type="entry name" value="CYTOFMRPINTP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYRIA/CYRIB Rac1 binding" evidence="1">
        <location>
            <begin position="59"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1286" mass="145979" checksum="E59AC6AC240969E4" modified="2015-04-29" version="1">MAAVPVEEAIAALSTFSLEDEQPEVQGPAVLVSTERGSTISPIEYSDVSAYRLSLTEDTKALNQLNTLIQDGKEMASVLYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEMSRLREIQRWQASAATKLAADMQRFSRPERRINGPTITHLWSMLKLLDVLVQLDHLKNAKASIPNDFSWYKRTFTQVSIQWPDTDSMREELDDLQIFLSTRWAILLNLHVEMFRVNNVEDILQVLIVFAVESLELDFALLFPERHMLLRVLPVLVVMATSSEKDSESLYKRVKINRLINIFKNDPVIPAFPDLHLSPTAILKELSNYFQKFSSQTRLLTLPSPHELPPREAQDYQRHYLIVNHIGAIRAEHDDFAIRFASAMNQLLLLKSTDGADVEWCKEVKGNMYDMVVEGFQLLSRWTARVWEQCAWKFSRPCKDVGPSDSQELSSSYSDYEKVVRYNYSAEERKALVELVSYIKSVGSTMQRSDTLIADALWETIHAEVQDFVQNTLATMLRTTFKKKKDLSRILSDMRTLSADWMANTNKPDSEFQSLQHGGDESRGNFFYPRPVAPTAAQVHCLQFLIYEVVSGGNLRKPGGLFGNSGSEIPVNDLKQLETFFYKLSFFLHILDYSATIATLTDLGFLWFREFYLESSRVIQFPIECSLPWMLVDHVLESQSAGLLESVLMPFDIYNDSAQHALVVLKQRFLYDEIEAEVDHCFDIFVTKLCEAIFTYYKSWSASELLDPSFLFALDNGEKYSIQPMRFTSLLKMTRVKLLGRTIDLRSLIAERMNKVFRENLEFLFDRFESQDLCAIVELEKLIDILKHSHELLSKDLSIDPFSLMLNEMQENISLVSFSSRLASQIWSEMQSDFLPNFILCNTTQRFIRSSKVPLVPVQKPSVPHAKPNFYCGTQDLNSAHQSFARLHSGFFGIPHMISLVKLLGSRSLPWLIRALLDHISNKIATLEPMITGLQETLPKSIGLLPFDGGVTGCMRLVKEQLSWGTKSELKAEVLRGIKEIGSVLYWMGLLDIVLRELDTTHFMQTAPWLGLLPGADGQMLSQNAGESPVVNLFKSATAAIVSNPRCPNPTSFYTMSKQAEAADLLYKANLNTGSVLEYALAFTSAALDKYCSKWSAAPKTGFIDITTSKDFYRIYSGLQIGYLEQSVQLQPNNHDMLGDSVAWGGCTIIYLLGQQLHFELFDFSYQILNVAEVEAASIMQTHKSPHSGQGWDSMLEAMKKARRLNNHVFSMLKARCPLEDKMACAIKQSGAPLPRIKFENTVSAFETLPQKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VF86</accession>
    <name>A0A0D2VF86_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G252300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VF86"/>
    <dbReference type="SMR" id="A0A0D2VF86"/>
    <dbReference type="STRING" id="29730.A0A0D2VF86"/>
    <dbReference type="Gramene" id="KJB68585">
        <property type="protein sequence ID" value="KJB68585"/>
        <property type="gene ID" value="B456_010G252300"/>
    </dbReference>
    <dbReference type="OMA" id="KYCNTRY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090558">
        <property type="term" value="P:plant epidermis development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000160">
        <property type="entry name" value="MYB-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47998">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB51-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47998:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR TRY-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB68585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="8350" checksum="B0C160896305A78E" modified="2015-04-29" version="1">MGDFDGHGSSNGCTSHDSKLKDKTKVRFSEDEEMLIARMFNLVGQRWSLIAGRIPGRTAEEIEKYWRSKHNPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFM2</accession>
    <name>A0A0D2VFM2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G058400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VFM2"/>
    <dbReference type="Gramene" id="KJB68770">
        <property type="protein sequence ID" value="KJB68770"/>
        <property type="gene ID" value="B456_011G058400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="75" mass="8446" checksum="94FDEDAB19ABE2FC" modified="2015-04-29" version="1">MENKLVEESEVASKKLKKSEGSTPLTKLFCSINWPVFVGKRGEKCNCNDRKSKCKAKTIHNLESLDPAFLLNYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIN9</accession>
    <name>A0A0D2VIN9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tropinone reductase I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G262200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family. SDR65C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIN9"/>
    <dbReference type="STRING" id="29730.A0A0D2VIN9"/>
    <dbReference type="Gramene" id="KJB83671">
        <property type="protein sequence ID" value="KJB83671"/>
        <property type="gene ID" value="B456_013G262200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0725">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SAINTMM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045000">
        <property type="entry name" value="TR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898:SF6">
        <property type="entry name" value="NADP-DEPENDENT MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42898">
        <property type="entry name" value="TROPINONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB83671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9197" checksum="A7699D2FBB707817" modified="2015-04-29" version="1" fragment="single">YSAINTMMIRHAIVEELAAFGAIVHKCSRTETELNDCLLEWKAKGLRVTGSVRDVSNQAQRENLLNTVSSEFNGKLNILVNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZY4</accession>
    <name>A0A0D2VZY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G160200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZY4"/>
    <dbReference type="Gramene" id="KJB77835">
        <property type="protein sequence ID" value="KJB77835"/>
        <property type="gene ID" value="B456_012G160200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QR4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="129"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="249"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB77835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="422" mass="46379" checksum="BC57ECB95A746126" modified="2015-04-29" version="1">MSVEFPYLYSSTALMCLMGSIQGALYAVCTVGDWNQWKLGWNVRLLAVAFVGIMGSSLFVFLVSWAVRLKGPLYIAIFNPLGLVLVAVVGSLLHDEKLHLGREYAASHIQSIWISACYSDENLGRKSLKKFNRKVLLQAFLCGLFGGSLVQNLYLQSLVHTSATFVAAIVNLAPAFTFILAICFKMEKLAIKTSAGKAKVCSTLIGIGGAMIFIFYKGIDVNIWSTDVNILKHHHQQVPSYHGTGQFIIGAFLGLLSCVSFCLWLIIQAKMSMGFPYLYSSTALMCLMGSIQGALYAVCTVRDWNQWKLGWNVRLLAVAYVGTMGSALFVFLISWAVRLKGPLYAATFNPLGLVLVAVVGSLLLDEKLHLGSIIGGLMIICGVYMVLWGRAKEMKQQTQESNETVEDEQEHEGTETPVIILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W5Q1</accession>
    <name>A0A0D2W5Q1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AIG1-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G135100</name>
        <name evidence="7" type="ORF">Gorai_002960</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0602793.1"/>
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    <dbReference type="InterPro" id="IPR027417">
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0602793.1"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="339" mass="37927" checksum="901EB2F51A6796C3" modified="2015-04-29" version="1">MMGGSAIDDDWEFTSPSNGIKTVVLVGRTGNGKSATGNSILGKKSFKSRASSSGVTSTCELQKTVLKDGQILNVIDTPGLFDFSAGSEFIGKEIVKCIDLAKDGIHAVLVVFSVRTRFSQEEEAALRSLQTLFGSKIVNYMIVVFTGGDELEENEETLEDYLGRECPQPLKDILGLCGNRLVLFDNKTKDETKRVKQVQDLLTLVNMVIEQNGGQPYTDELFAELKKGATKLRDQQEVVAALKGYSKREISEFKEQIERSYEEQLMRITEMVESKLKETTVRLEQQLAEEQAARLKAEELAQLAQMKSNDEIRKLRENLERAQKETEELRKQAARCAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W882</accession>
    <name>A0A0D2W882_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G215300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_013G215300"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="entry name" value="EmrE-like"/>
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        <property type="entry name" value="Sugar_P_trans_dom"/>
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    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
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    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="159"/>
        </location>
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            <end position="189"/>
        </location>
    </feature>
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            <end position="370"/>
        </location>
    </feature>
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        <location>
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            <end position="393"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB82815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="430" mass="48963" checksum="637749A9561AC62C" modified="2015-04-29" version="1">MEKAQEEMVYSIHHKKTTKPSERYPYDLICFRHTFTKTNSIFSFHCSLPYFPTIRSDPFLLFFLFIHHFPYLSIFQKTRKKQQHNRTMGKGGSLSDNVIKNIILSYTYVCIWIFLSFTVIVYNKYILDKKLYNWPFPISLTMIHMSFCATLAFLLIKVFKFVEPVSMSRELYLSSVVPIGALYSLSLWLSNSAYIYLSVSFIQMLKALMPVAVYSMGVLFKKETFKTDTMVNMISISFGVAIAAYGEARFDSWGVMLQLGAVAFEATRLVMIQILLTSKGITLNPITSLYYVAPCCLVFLLVPWIFVEYPVLKDTSSFDFDFVIFGTNSFCAFALNLAVFLLVGKTSALTMNVAGVVKDWLLIAFSWSVIKDTVTPINLFGYGVAFLGVAYYNHAKLQALKAKEAEKKVGQADEEGERLIEERQGEGSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2008-07-01" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>B2ZAQ5</accession>
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        </submittedName>
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        <name evidence="4" type="ORF">B456_011G036700</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2008" name="Mol. Biol. Evol." volume="0" first="0" last="0">
            <title>A phylogenetic analysis of indel dynamics in the cotton genus.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Yu Y."/>
                <person name="Wing R.A."/>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2008-04" db="EMBL/GenBank/DDBJ databases">
            <title>A phylogenetic analysis of indel dynamics in the cotton genus.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Yu Y."/>
                <person name="Wing R.A."/>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="EU626442">
        <property type="protein sequence ID" value="ACD56622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="B2ZAQ5"/>
    <dbReference type="SMR" id="B2ZAQ5"/>
    <dbReference type="Gramene" id="KJB68829">
        <property type="protein sequence ID" value="KJB68829"/>
        <property type="gene ID" value="B456_011G036700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778162"/>
    <dbReference type="eggNOG" id="KOG0013">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PINMIHE"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DC-UbP/UBTD2 N-terminal" evidence="2">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ACD56622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB68829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="13123" checksum="2F367D99D14413BA" modified="2008-07-01" version="1">MGCTGSKRTRGDENVKKIRKPKPWKHSEPITRTQLKQMRDEFWDTAPHYGGQREIWDALRVAAESELTHAQAIINSAGVIVQNDDLTICYDERGAKYELPKYVLSEPINMIHEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>M9Z397</accession>
    <name>M9Z397_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">KCS21</name>
        <name evidence="11" type="ORF">B456_007G009500</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Functional analysis and molecular cloning of Gossypium raimondii KCS genes.</title>
            <authorList>
                <person name="Xiao G.-H."/>
                <person name="Li Q."/>
                <person name="Zhu Y.-X."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="KC160470">
        <property type="protein sequence ID" value="AGK30004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M9Z397"/>
    <dbReference type="STRING" id="29730.M9Z397"/>
    <dbReference type="Gramene" id="KJB39374">
        <property type="protein sequence ID" value="KJB39374"/>
        <property type="gene ID" value="B456_007G009500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRZR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSWWYEL"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="8">
        <location>
            <begin position="48"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="9">
        <location>
            <begin position="351"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AGK30004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB39374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="457" mass="51882" checksum="1668C8089ED363E5" modified="2013-06-26" version="1">MLSKPTFFAFIIVAFEALFILQQWRHPIFHFLLLSYFFFAIKTYFLKSKQPRPVYLVDFLCYKPPSKCKVPFSSFIHHASMIEAFDTESVEFMAKTLVSSGLSQETYLPPALHCIPPKTHDRESINEAQMVLFPVMDELLSKTKLSPYDIDILILNCSGFCPSPSLSSIIINKYSMKSDIKSYNLSGMGCSAGTIGVDLAQNLLKTHENKTAIVLSTEILSTGWYSGHEKPKLILNCVFRMGGAGILLSNKKQAENTSKYKLIHSLRTQRAYDDTAYYAVYREEDSRGILGVTFNKDLLQAVSETLRSHITLLGSQILPFTEQFFHVISILRKKLIDESAEIYTPRFKTVVQHFCLPSSGKPLIREVAKGLNLNGRNIEPALMTLHRFGNQSSSSWWYELGYMEGKWRVKKGDKIWVLGLGTGIKCCSLVLECLRPIVEDDKKSPWSCCIQQYPIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LVK5</accession>
    <name>A0A0D2LVK5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G068200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. In the endosomes, drives the retriever and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex. Component of the heterotrimeric retriever complex consisting of VPS26C, VPS29 and VPS35L; within the complex interacts with VPS35L. Interacts with SNX17 (via C-terminus); the interaction is direct and associates SNX17 with the retriever complex. Interacts with SNX31; the interaction is direct.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LVK5"/>
    <dbReference type="STRING" id="29730.A0A0D2LVK5"/>
    <dbReference type="Gramene" id="KJB08145">
        <property type="protein sequence ID" value="KJB08145"/>
        <property type="gene ID" value="B456_001G068200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08147">
        <property type="protein sequence ID" value="KJB08147"/>
        <property type="gene ID" value="B456_001G068200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048768">
        <property type="term" value="P:root hair cell tip growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000009">
        <property type="entry name" value="Down syndrome critical region protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000023">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00067597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00093280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00093474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB08147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="328" mass="36444" checksum="A0EE193AB357FDC4" modified="2015-04-29" version="1">MSTKIDLSLSRPNRIYRPSEPLEGKILVKSASSISHYGIRMAINGSVNLQVRGGSAGVIESFYGVVKPITILSRTLEIRPSGKIVSGTTEIPFSITLRNPKEDNSERFYETFHGTNISIQYLATVDIMRGYLHKSLSATVEFIVESDKADLLNPPISPEMVIFYITQDTQRHPILPELKSGGFRITGRISTQCSMLEPLSGELTVEASVLPICSIDIHLLRVESVLLGEKIITETSLIQTTQIADGDVCRNMTLPIYVVLPRLLTCPTVLAGPFSIEFKVAIVIFFQSELSRLHPKSDPLTPRLWMAMETLPLELVRARPYASWTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LX77</accession>
    <name>A0A0D2LX77_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proline-tRNA ligase class II C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G106400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LX77"/>
    <dbReference type="STRING" id="29730.A0A0D2LX77"/>
    <dbReference type="Gramene" id="KJB08827">
        <property type="protein sequence ID" value="KJB08827"/>
        <property type="gene ID" value="B456_001G106400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2018">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4163">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline-tRNA ligase class II C-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="173" mass="19777" checksum="B911ACC04EA20DB1" modified="2015-04-29" version="1">MKNLKVRAVRCDNGEKTDISRVFLVEQVKRMLDKIQQNLFDVAKQKRDACIEVVKTWDEFVKALGQKKLILAPWCDEEEVEKDVKARTRGEMGAAKSLFVPHSNSLNSQKVRHRLRKDHGIEGGIPVVFSLEKPKAQLLPFRGPSGEEDNPSDYQVRMLASYFCSFKVLCLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M925</accession>
    <name>A0A0D2M925_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin B-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G102900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Acts as a calcium sensor. CBL proteins interact with CIPK serine-threonine protein kinases. Binding of a CBL protein to the regulatory NAF domain of a CIPK protein lead to the activation of the kinase in a calcium-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer. Interacts with CIPK.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M925"/>
    <dbReference type="STRING" id="29730.A0A0D2M925"/>
    <dbReference type="Gramene" id="KJB13947">
        <property type="protein sequence ID" value="KJB13947"/>
        <property type="gene ID" value="B456_002G102900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019900">
        <property type="term" value="F:kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000073">
        <property type="entry name" value="calcineurin B-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045198">
        <property type="entry name" value="CNBL1-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056">
        <property type="entry name" value="CALCINEURIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23056:SF135">
        <property type="entry name" value="CALCINEURIN B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="82"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="119"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="163"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU369080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="226" mass="25965" checksum="7D38AF4D8140735F" modified="2015-04-29" version="1">MLQCIDGLKHLFASVLQCCDIDLYKQSRGLVDPELLARETVCIVSEIEALYELFKKISSAVIDDGLINKEEFQLALFKTNKKESLFADRVFDLFDTKHNGILGFEEFARALSVFHPNAPIDDKIDFSFQLYDLKQQGFIERQEVKQMVVATLAESGMNLSDDVIESIIDKTFEEADTKHDGRIDKEEWRSLVLRHPSLLKNMTLQYLKDITTTFPSFVFHSQVDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M970</accession>
    <name>A0A0D2M970_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_002G105600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M970"/>
    <dbReference type="Gramene" id="KJB13997">
        <property type="protein sequence ID" value="KJB13997"/>
        <property type="gene ID" value="B456_002G105600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGTDVEC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF55">
        <property type="entry name" value="OS07G0686300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="56"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="134" mass="15631" checksum="10C0FBE7681B93CA" modified="2015-04-29" version="1">MAIDNKLGNYTFSLVSIVSAVKWAWSILLRYCLFPYPIPADIGYDYKQDWGTDVECAICLCKIDEDDEIPELRCDHLFHKACLDRWVGSRRFTCPICRTCTLTPPQLASGMQVMVFRYCSFDDSSSHRETWWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MT67</accession>
    <name>A0A0D2MT67_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G036900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MT67"/>
    <dbReference type="STRING" id="29730.A0A0D2MT67"/>
    <dbReference type="Gramene" id="KJB22246">
        <property type="protein sequence ID" value="KJB22246"/>
        <property type="gene ID" value="B456_004G036900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22247">
        <property type="protein sequence ID" value="KJB22247"/>
        <property type="gene ID" value="B456_004G036900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1039">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QQTNVEM"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16521">
        <property type="entry name" value="RING-HC_MKRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045072">
        <property type="entry name" value="MKRN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224:SF10">
        <property type="entry name" value="IP09428P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11224">
        <property type="entry name" value="MAKORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="211"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="9">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB22247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="364" mass="40356" checksum="D0BF72EE01B84449" modified="2015-04-29" version="1">MPKTKGVLCKFFAHGACFKGENCEFSHDWKDPPNNICTYYQKGICSYGSQCRYEHVKASQTDLSASSSSTKPRQFGVSGSAPLGPSTSTYCGSVVLPATSGEFPGSNGGFLPPSTNQAWHLESGQQDLLDDGDVLQPRSANLVELPICSFAAAGNCPRGDNCPHIHGDLCPTCGKHCLHPFRAEEREEHVKMCEKKQKHLEALKYSQEIECSVCLDRVLSKPTAAERKFGLLSECDHPFCISCIRNWRSSSPSSGMDVNTALRACPICRKLSYFVIPSVIWYSTPEEKQEIIDSYKAKLRSIDCKHFNFGNGNCPFGTSCFYKHAYRDGRLEEVALRHLGAEDGHTVIAKNIRLLDFLSDLHIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MUI2</accession>
    <name>A0A0D2MUI2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein AAR2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G064600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUI2"/>
    <dbReference type="STRING" id="29730.A0A0D2MUI2"/>
    <dbReference type="Gramene" id="KJB22752">
        <property type="protein sequence ID" value="KJB22752"/>
        <property type="gene ID" value="B456_004G064600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790556"/>
    <dbReference type="eggNOG" id="KOG3937">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VWQSGGL"/>
    <dbReference type="OrthoDB" id="201752at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070877">
        <property type="term" value="C:microprocessor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010445">
        <property type="term" value="C:nuclear dicing body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13778">
        <property type="entry name" value="Aar2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13777">
        <property type="entry name" value="Aar2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.550:FF:000002">
        <property type="entry name" value="AAR2 protein family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.20:FF:000001">
        <property type="entry name" value="protein AAR2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.550">
        <property type="entry name" value="Aar2, C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007946">
        <property type="entry name" value="AAR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033648">
        <property type="entry name" value="AAR2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038514">
        <property type="entry name" value="AAR2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033647">
        <property type="entry name" value="Aar2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038516">
        <property type="entry name" value="AAR2_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689">
        <property type="entry name" value="A1 CISTRON SPLICING FACTOR AAR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12689:SF4">
        <property type="entry name" value="PROTEIN AAR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05282">
        <property type="entry name" value="AAR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20981">
        <property type="entry name" value="AAR2_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAR2 N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AAR2 C-terminal" evidence="2">
        <location>
            <begin position="194"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB22752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="398" mass="45319" checksum="F35DE9E7B1F0495E" modified="2015-04-29" version="1">MMDADKALELVKSGATLLLLDVPQYTLIGIDTQVFSVGPAFKGIKMIPPGVHFVFYSSSTRDGKEFSPITGFFIDAGYSQVVVRMWDQQEERLIKVPEEEEERYRQAVRSFEFDKHLGPYDLSLYADWKRLSNYITKSTIERLEPIGGEITVTYEHGMLKNTCKSAMERVLDEQLRNSKFSSPAEKHPKRGCYYTPIPRIIKRKGIESEQLTSLNLDKTELLETLLVKDYGGSEESLLGELQFAFIAFLMGQSLEAFMQWKSLVSLLLGCTEAPFQTRSQLFTKFIKVIYYQLKYGLQKDRSVGEAGTSALLDDSWFSSDSFLHCFCKDFFSLVQDASVVDGDLLSWTRKLKELLENSLGWEFQQKSAVDGIYFEENDEYAPVVEMLDEPSGSEPTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MYD1</accession>
    <name>A0A0D2MYD1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_004G146100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MYD1"/>
    <dbReference type="STRING" id="29730.A0A0D2MYD1"/>
    <dbReference type="Gramene" id="KJB24452">
        <property type="protein sequence ID" value="KJB24452"/>
        <property type="gene ID" value="B456_004G146100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETISRCH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016004">
        <property type="term" value="F:phospholipase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
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        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
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        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB24452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="184" mass="20995" checksum="570568F71BBB2FC4" modified="2015-04-29" version="1">MGLSFTKLFSRLFAKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIANKVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N0T5</accession>
    <name>A0A0D2N0T5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G196100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB25487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N0T5"/>
    <dbReference type="Gramene" id="KJB25487">
        <property type="protein sequence ID" value="KJB25487"/>
        <property type="gene ID" value="B456_004G196100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000006">
        <property type="entry name" value="2-oxoglutarate-Fe(II) type oxidoreductase hxnY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF590">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IPNSYNTHASE"/>
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    </dbReference>
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        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="160"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB25487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="305" mass="34755" checksum="63A03F0414C0D844" modified="2015-04-29" version="1">MPDALQFPIIDLSFPDRFSIANLIRQGCVDHGFFYLVNHGVDEELISKVFEQSSNFFSLPIEEKMKLVRKNHRGYTALYAEKLDTTLTTEGDSKESFYIGPLADDLNQWPLEEDLPSWRSTMETYHQKLLSAVTKLLSLIALSLKLEEDFFEKVGALIEPLAFIRLLHYPGDLNSSSEEIFGASAHSDYGMVTLLVTDGVPGLQICREKSKQPQVWEDVPSMSGAFIVNIGDMMERWTNGLFRSTLHRVLQPRQDRYSVAFFTNPSKDCTVECLESCCTESCPLRFPPIKAIDYLEERLRLTYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N530</accession>
    <name>A0A0D2N530_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G287100</name>
        <name evidence="3" type="ORF">Gorai_015786</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N530"/>
    <dbReference type="Gramene" id="KJB27257">
        <property type="protein sequence ID" value="KJB27257"/>
        <property type="gene ID" value="B456_004G287100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7DB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEKMEGW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37265:SF8">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37265">
        <property type="entry name" value="OS01G0195300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB27257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0584993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="191" mass="20451" checksum="1374869ADF1CED49" modified="2015-04-29" version="1">MLMLGSPEYGFSGEAAGKLNVLLTESDDESEFSNDEGKLEEIMQELYKEITATTTSSSPNTSPPMVTLPSPSSSSSSSSPPLYLSPPPFSVSDVKSESCGASMSDSSSTVMAGIEFVVHAGKLPEKEIGVTEMGFDDDNNTTTTINNNNNNSGDFVAREEEMDGCDEGELGNDQWLTIILGWGPLELEDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NFC9</accession>
    <name>A0A0D2NFC9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IST1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G191700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NFC9"/>
    <dbReference type="STRING" id="29730.A0A0D2NFC9"/>
    <dbReference type="Gramene" id="KJB31432">
        <property type="protein sequence ID" value="KJB31432"/>
        <property type="gene ID" value="B456_005G191700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794756"/>
    <dbReference type="eggNOG" id="KOG2027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSKHICA"/>
    <dbReference type="OrthoDB" id="29853at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.60:FF:000003">
        <property type="entry name" value="IST1-like protein isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.60">
        <property type="entry name" value="Vacuolar protein sorting-associated protein Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005061">
        <property type="entry name" value="Ist1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042277">
        <property type="entry name" value="IST1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161">
        <property type="entry name" value="IST1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12161:SF81">
        <property type="entry name" value="OS01G0687700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03398">
        <property type="entry name" value="Ist1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35300" checksum="64A7B49F78C90F19" modified="2015-04-29" version="1">MSLLNQLFNRGVFGAKCKTCLSLAISRIKLLQNKRDLQLKNMRKEIAQFLQAGQEPIARIRVEHVIREQNIWAAYEILELFCEFVLARVPILESQKDCPPELREAVASIIFAAPRCSDVPDLLQIKNLFATKYGKEFVIAAMELRPDSGVNRAIIEKLSVSAPSGEIRLKVLKEIAQEYSVEWDSSGTEAEFNKKYEDLLAGSKQVCAEAAVSQAPSKQASGKSLPSNGAKTILPTDARPASQHHQVPSHMSKLTSSEIESSVKNGTAGPISDIKTETNSRPSDVLERARAAIASAERATAGARAAAELVNVKFGSLKLQGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NIT4</accession>
    <name>A0A0D2NIT4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G060000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NIT4"/>
    <dbReference type="STRING" id="29730.A0A0D2NIT4"/>
    <dbReference type="Gramene" id="KJB13168">
        <property type="protein sequence ID" value="KJB13168"/>
        <property type="gene ID" value="B456_002G060000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778048"/>
    <dbReference type="eggNOG" id="KOG3475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THALCHR"/>
    <dbReference type="OrthoDB" id="963097at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF25">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL37X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB13168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="95" mass="10803" checksum="8E3567E89318EAA0" modified="2015-04-29" version="1">MGKGTGSFGKRRNKTHTLCVRCGRRSFHLQKSRCSACAFPAARKRTYNWSVKAIRRKTTGTGRMRYLRHVPRRFKTGFREGTEAAPRKKVATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NK25</accession>
    <name>A0A0D2NK25_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G010400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NK25"/>
    <dbReference type="Gramene" id="KJB33422">
        <property type="protein sequence ID" value="KJB33422"/>
        <property type="gene ID" value="B456_006G010400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798117"/>
    <dbReference type="OMA" id="HTKIHEL"/>
    <dbReference type="OrthoDB" id="1903715at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36747">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36747:SF1">
        <property type="entry name" value="HYDROXYPROLINE-RICH GLYCOPROTEIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB33422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="105" mass="11766" checksum="DD3CCC9EA75CAB71" modified="2015-04-29" version="1">MGNPNFNCSIQSENAELKKIDEKVLQESGNDLPKTCTPRRLNLPNAFNFPERYRSPTDSVVSPVPRGLLARNRKAGGSLLPPSINHTKIHELRVEEIGLFSELKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NLQ4</accession>
    <name>A0A0D2NLQ4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G117600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NLQ4"/>
    <dbReference type="Gramene" id="KJB14283">
        <property type="protein sequence ID" value="KJB14283"/>
        <property type="gene ID" value="B456_002G117600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="112" mass="13179" checksum="902EECC2F694379F" modified="2015-04-29" version="1">MQPQMLQLVIRVLSERLHLWACIVGQPYYTSTNRRHRGRSTTPRNQQQENFFINGSFSLSGSELRELVGNKHPSLRTRLMVRKDLLQEGWLEISCKNISPAQFIMTIFRPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NUX4</accession>
    <name>A0A0D2NUX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G015300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NUX4"/>
    <dbReference type="Gramene" id="KJB17783">
        <property type="protein sequence ID" value="KJB17783"/>
        <property type="gene ID" value="B456_003G015300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1470">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000008">
        <property type="entry name" value="Phosphatidylinositol transfer protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF17">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN C23B6.04C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="118"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB17783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="316" mass="36321" checksum="A30F22230B2F35F7" modified="2015-04-29" version="1">MIPINEIQRLEKTRNYRVVKSSMLLKQGSSLFGEFCFLCRVSELRTAIGPLSGRSAKYCTDACLRRYLEARNWNVDKAKKMLEETLKWRLTYKPEEIRWHEVAHEGETGKVSRANFHDHQGRTVLIMRPGMQNTKSAENNIRHLVYLLENAIMNLAEGQEQMSWLIDFTGFSLNTSIPIKVARDIVYILQGHYPERLAVAFLCNPPKIFEAFYKAVKYFLDPKTAQKVKFVYPKNKDSMELMKSYFDVEDLPVEFGGNGTLKYDHEEFSRLMAEDDVKTAKFWGIDDKPYHIANGSGHSAAEVAPEPVAPIAQRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NX15</accession>
    <name>A0A0D2NX15_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G060300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NX15"/>
    <dbReference type="STRING" id="29730.A0A0D2NX15"/>
    <dbReference type="Gramene" id="KJB18563">
        <property type="protein sequence ID" value="KJB18563"/>
        <property type="gene ID" value="B456_003G060300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788008"/>
    <dbReference type="eggNOG" id="ENOG502QQ6S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAMRVES"/>
    <dbReference type="OrthoDB" id="191334at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044174">
        <property type="entry name" value="BC10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042">
        <property type="entry name" value="CORE-2/I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042:SF122">
        <property type="entry name" value="CORE-2_I-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB18563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="383" mass="44711" checksum="11840ACF0C4AB9E5" modified="2015-04-29" version="1">MQARMVAMEEGKDQASAIRTSISRTLPLRLLLFCLLFAVLAIGLSIICMYSLRFFIFQQTVAPSTFRPWFEEVHTIERWIRPPTNLWHSINDNELLWRASFVPKIKQYPFLRVPKIAFMFLTKGPLPLAPLWDRFFKGNERHCSIYVHALPSYISGYPQSSAFHRRQIPSQMVEWGKMSMCEAERRLLANALLDISNEWFILLSESCIPLYNFSVIYHYISRSNHSFMESYDDPGPYGRGRYDSRMEPEVTLGQWRKGSQWFEVNRMLAINIIEDNKYYPKFKEFCQPACYVDEHYFTTMLTIQVPHLLANRTLTWTDWSRGGAHPATFGKDDMTEAFFQKIFEGQACLYNGQPTSLCFLFARKFAPNALDPLLELAPKVFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NYT2</accession>
    <name>A0A0D2NYT2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pectinesterase</fullName>
            <ecNumber evidence="4 12">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_006G260800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10 12">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Secreted</location>
            <location evidence="12">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 12"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NYT2"/>
    <dbReference type="STRING" id="29730.A0A0D2NYT2"/>
    <dbReference type="Gramene" id="KJB38562">
        <property type="protein sequence ID" value="KJB38562"/>
        <property type="gene ID" value="B456_006G260800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPZF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LCHSTEY"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018040">
        <property type="entry name" value="Pectinesterase_Tyr_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00800">
        <property type="entry name" value="PECTINESTERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="12" id="KW-0134">Cell wall</keyword>
    <keyword evidence="12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113163" description="Pectinesterase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="13">
        <location>
            <begin position="39"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB38562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="561" mass="61039" checksum="4501364AFC238C32" modified="2015-04-29" version="1">MANNAIIGICAVFLVALVVAVVVGVTHIKNKSDGEEISSSNKAVQALCQPTNYKETCQKSLASSNSSDVKELIRTGFQAGLVEIKNVLAHSVTVQELIKDENNKAALGVCQEVLDLAIDDFQKSFDMLGEYDMSKIGKYLLELKTWLSGAFTSQQTCIDSFAESSNESSQKMQSILKTSMEITSNALAMLNGLSTIVKELNIPNVGNIDTTGVNRKLLSAEDMPEWISQADRKLLQAKPMDLKPNVVVAKDGSGKYDTINKALAEVPVKSPDRFVIHIKAGTYKEQINVTKQMTNVVFVGDGPTKTIITNDISVAKNPPVKTYRTATVAADGAGFMAKDIGFDNSAGPEGHQAVAFRATADRVIMFNCHFTGYQDTLYAHRERQLYSNCLITGTVDFIFGDAASIFQNCMLVVRKPGPGQNCMVTAQGRNDLGTNSAIVLQNCTISGAPDYIPVKDTNKAYLGRPWKQFARSIIMQSRIDDIIQPEGYAPMTGTIGIDTSFIAEFGNRGPGADTSRRVAWKGIKKIDINEANKWTPRVFLESETWIPSSGIPYSPDMVPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1Z2</accession>
    <name>A0A0D2P1Z2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_003G152300</name>
        <name evidence="17" type="ORF">Gorai_024857</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P1Z2"/>
    <dbReference type="STRING" id="29730.A0A0D2P1Z2"/>
    <dbReference type="Gramene" id="KJB20508">
        <property type="protein sequence ID" value="KJB20508"/>
        <property type="gene ID" value="B456_003G152300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789060"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFYDEDC"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000653">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF151">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="15">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB20508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0582723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="407" mass="46023" checksum="DE708FC522B40B81" modified="2015-04-29" version="1">MLEIGHAPGNALFGKYEIGRLLGCGAFAKVYHARNLRTGLSVAVKVINKKKLPSLTMMSNVKREISIMSRLNHPYIVKLYEVLATKTKIYVVMEFVKGGELFAKVAKGRFTEDLSRKYFQQLISAVGYCHSRGIFHRDLKPENLLLDDNGNLKVSDFGLSAVTDQIRADGMLHTLCGTPAYVAPEILSKKGYDGAKVDVWSCGVILFVMNAGYLPFNDPNLMAMYRKIYSGEFRCPKWMSSDMKRFISRLLDTNPVTRISLDEILKDPWFRKGYKEPKFHEEQPKDDAQASSSKLNAFDLISFSSGLNLSGLLDESHDYGERFILRESPEKLVEKVEQLGKGERMKVKKKKQWGVELEGKEGISGVAIEVYQLTDELVVVETKRTGSDAQWYKELWNNKLRPALVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PL86</accession>
    <name>A0A0D2PL86_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G012500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PL86"/>
    <dbReference type="STRING" id="29730.A0A0D2PL86"/>
    <dbReference type="Gramene" id="KJB27838">
        <property type="protein sequence ID" value="KJB27838"/>
        <property type="gene ID" value="B456_005G012500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2315">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000599">
        <property type="entry name" value="Eukaryotic translation initiation factor 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="10">
        <location>
            <begin position="250"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="472"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB27838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="549" mass="60080" checksum="57FD32CED0D7E5AC" modified="2015-04-29" version="1">MVSRSGKFSIADLQEKKVQPTAAQIARYDHPMAAAVEISPVLEILVREPDGYSIWNGPPFKNNNQPGIKLEKVPCNNAKYSEDGSRIMVTKTDSAIGIYDSNTLKEIRCFQIPNVVASALSPCGAYLQTFQKSTTPQEKNVVLWSIETGDPVYEQFQKNMTKATWPLIRFSSDEAVACRLATNEIQFFDAADFSKGISHRLRVPGVAAVELSRAPGSHVAAFVPESKGSPASVQIYACAKELQSQPLARRSFFRCSTVQLHWNHGSTGLLVVVQSDVDKTNQSYYGESKLHYLTTDGAFEGLVPLRKEGPIHDVQWSYSGKEFAVVYGFMPASATVFDKKCKPVHELGSGPYNTVRWNPKGKLLCLAGFGNLPGDMAFWDIIDKKQLGTTRAECSVTSEWSADGCYFMTATTAPRLQVDNCVKIFSYNGSLLFKKMFNKLFQADWKPESPDKFGEIAELIKSVGSVKIEETKSLGQGSTTKKPASANPPAQKPAAYRPPHAKNAAAVQAELFGGSSTGEMSKNALKNKKKREKQKEKKAAEAAAASGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLM5</accession>
    <name>A0A0D2PLM5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G043900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLM5"/>
    <dbReference type="STRING" id="29730.A0A0D2PLM5"/>
    <dbReference type="Gramene" id="KJB07754">
        <property type="protein sequence ID" value="KJB07754"/>
        <property type="gene ID" value="B456_001G043900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780205"/>
    <dbReference type="eggNOG" id="ENOG502S29N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGCPHAK"/>
    <dbReference type="OrthoDB" id="778717at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF38">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="150"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB07754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="232" mass="25945" checksum="D482710F29FF394A" modified="2015-04-29" version="1">MELQLGLSTPIFPFKMLDLNSYGYELREGLGPFGINVNNNCDSCSSSCSSSSSGGADDGGGGTKKRRLLDEENRIVPKTLPLLFWTNQRPNDEDEPKDVDDHSSSAIFKNDGEGLVGWPPVKAWRKKVRRRVANVRAAVENSCGGRASSSTYVKVKMEGNAIARKIDISLHHSFESLTTTLMRMFDISDENGQKSFKLTYLDREGDWLLAEDVPWRTFIGSLKYIKLIRSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PP54</accession>
    <name>A0A0D2PP54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G092600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PP54"/>
    <dbReference type="STRING" id="29730.A0A0D2PP54"/>
    <dbReference type="Gramene" id="KJB08594">
        <property type="protein sequence ID" value="KJB08594"/>
        <property type="gene ID" value="B456_001G092600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789553"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB08594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="54778" checksum="FE84C83D2313C78C" modified="2015-04-29" version="1">MEIEEDEERRRQRKLEEALEVKSLRRIISAYLNYPEAAEEDVRRYEKSFKKLPPAHKALLPHYPSKFQNLRRCISLNSYFIFTMLQAFEPPLDMSQDVDGCKDPHLENFEHGHCHSEERNASSCQSASTSGRMCCSNHAQACSQEKSNIMSNPTTELQEVKSEQQHEPIFGSGAGEVENNNEIAECCSNDVADSNGNAFSSPHDWLDPSLQLNVPLVDVDKVRCIIRNIVRDWAAEGEKERNQCYKPILEELDAQFPNRSKESPPACLVPGAGLGRLALEISCLGFISQGNEFSYYMMICSSFILNHTETTGQWTIYPWIHSNCNSLSDNDQLRPVLIPDIHPASAGITEGFSMCGGDFVEVYNDSSQIGVWDAVVTCFFIDTAHNIIEYIEIISRILKEGGVWINFGPLLYHFADMYGQEDDMSIELSLEDVKKIAFHYGFELEKEQTIETTYTTNPRSMMQNHYHAAFWTMRKKRTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PQM2</accession>
    <name>A0A0D2PQM2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carboxypeptidase</fullName>
            <ecNumber evidence="11">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G128600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Probable carboxypeptidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="11"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PQM2"/>
    <dbReference type="MEROPS" id="S10.A41"/>
    <dbReference type="Gramene" id="KJB09189">
        <property type="protein sequence ID" value="KJB09189"/>
        <property type="gene ID" value="B456_001G128600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SASCIET"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000030">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF473">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113209" description="Carboxypeptidase" evidence="11">
        <location>
            <begin position="26"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB09189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="443" mass="49371" checksum="15ADC9BD44EFECC8" modified="2015-04-29" version="1">MEGVACTWMLLSMCLLGYLIIYVEANEAKVLGNFLKSRLSKKSSSAVHSWAWLNEKTGDSPNYIQPQDGSMEADKIGALPGQPNGVDFNHYSGYVTVDSKAGRALFYYFAESPDKSSTNPLVLWLNGGPGCSSLIGAMMELGPFRINNDGKTLFRNDYAWNNVANVIFLESPAGVGFSYSNTSSDYHHIGDKSTAKDAYTFFVNWLERFPQYKTRDFYITGESYAGHYVPQLAYTILLNNKNANQTLINLKGIAVGNGWIDDRTGYLGQYDYLWTHALNSDETNKGIHAYCHQMSVNSFDPCSDYYMISYLNRPEVQTALHAGVAKWHKCSYSIFGWTDSPASVLPIFKNLMASGLRVWLYSGDVDSVVPITSTRYAINELKLPLKTAWRAWSTDNQVGGYVEEYEGLTLVTVRDAGHLVPSYQPARSLTMISSFLLGLLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSC9</accession>
    <name>A0A0D2PSC9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G101000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSC9"/>
    <dbReference type="Gramene" id="KJB49102">
        <property type="protein sequence ID" value="KJB49102"/>
        <property type="gene ID" value="B456_008G101000"/>
    </dbReference>
    <dbReference type="OMA" id="CNLDQAF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB49102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11050" checksum="26B93CC9E2C20FFA" modified="2015-04-29" version="1">MNSISTTAVDTSCRSPVSKPRAEPIKGYPVSLLQIYWLGFFTINPKSRKSQSNVSKKTIFGLALTTARSSCNLDQAFLSCQLNPSLFKLNHTEKNIKLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PT03</accession>
    <name>A0A0D2PT03_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G141300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PT03"/>
    <dbReference type="STRING" id="29730.A0A0D2PT03"/>
    <dbReference type="Gramene" id="KJB30398">
        <property type="protein sequence ID" value="KJB30398"/>
        <property type="gene ID" value="B456_005G141300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794195"/>
    <dbReference type="eggNOG" id="ENOG502QTPI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EDSAECF"/>
    <dbReference type="OrthoDB" id="772197at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012870">
        <property type="entry name" value="DUF1666"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46741:SF4">
        <property type="entry name" value="FINGER FYVE DOMAIN PROTEIN, PUTATIVE (DUF1666)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46741">
        <property type="entry name" value="OS09G0413600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07891">
        <property type="entry name" value="DUF1666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="757"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="850" mass="98466" checksum="FAF97C33BC2891E9" modified="2015-04-29" version="1">MGREIILALIKIDSMCTIRFIMLKKTHFDFRFGFMHGFLYTNMLPVVASFWVFLSKFIAYVFGSIPGYLFRPSAIKRFAEKDSGACSDSNFDGVKERQNSDHVDQGNREADKFSLVASSSKYEFLYRKGFSGFIKEPKAESYSVHEFYMGSANCDGRILVSRDSADADIGKIEVEAEDPGESFTVEKVEENCLQVNFVDERETEEPVEEISESLMLENVLQKEPQPGETDFVLENETEESALRFFFEKDFEKYIKQEESVEEKKPEQNIIKIEDVVKEIPKDFVEKLSEKPKHGEIETKDSFKEKAQESVEERSEKDASDIQGHGDHVEDNLDYFFVIDMYIEKPKKDGEIFSPRNNVVDVESIAQQVLANRLDLSYVLTDAQNMEHGIHERTSNIIRSPINDSDEEFIELEPRSEKLRVMGEDLSIEDEGDEEEFNSMVSPEKTQQTTLREEFIFSSCDEQEEEDNDDDSEFSSEDDDLMERLKIELKLARTGGLPTILEDSESPKMVEQLGPLKIEEKYDHKNHIAEIQKVYKSYSDKMRKLDILNSQTMHAVSLLQLKDPVRLSSAFGRSSAPAIKSLLSHNVWPFKQQKPEADPAMKSIRDLHMAFETVYVGQVCLSWEILHWQYGKVNRLWECDSLATHQYNQAAGKFQRFQVLVQRFLEDEPFQDRPRVENYAKNRCALRLLLQIPVIEDDCSKYKLEGAVSNGVLSDMIEESMHVLWEFLRADKDNTNATSKTPQQAQVAPHDPIDLELLMDVRTELQKKEKRLKEIQRNTNCIIKRLQRQHQRNLLDHTLFIAQVELKLVSRVLNMLKISTDQLIWCHEKLQRINFGSRKTEIEPSFTLFPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PT63</accession>
    <name>A0A0D2PT63_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G153800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PT63"/>
    <dbReference type="Gramene" id="KJB07241">
        <property type="protein sequence ID" value="KJB07241"/>
        <property type="gene ID" value="B456_001G153800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXG5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007789">
        <property type="entry name" value="DUF688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34371:SF2">
        <property type="entry name" value="DUF688 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34371">
        <property type="entry name" value="OS01G0551000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05097">
        <property type="entry name" value="DUF688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB07241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="243" mass="27287" checksum="DE99D37FE37EB8F9" modified="2015-04-29" version="1">MGTEAENESSYTPKLPLFSAPQAHMQSPERSGTSTPPLHVSASVPFRWEDEPGKPKPCTTLTLFSNPNHLAQKCLELPPRLLQDAKSTTVLEPARLQSSSSFRMGSECYGSFRVGSVSPERVQLGTMVLSKRGTYKDKGFLGSWKRKTFKAKREVGGAGKSYVFPSSGDKDSECSREEEEEEEEESNSSSVKTTRIKRVGSFHNLFNSKSHFWVRFISQFLYKFIVFEGCCYATFMVFITNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUG3</accession>
    <name>A0A0D2PUG3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G137900</name>
        <name evidence="11" type="ORF">Gorai_009532</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the WRKY group II-c family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUG3"/>
    <dbReference type="Gramene" id="KJB49782">
        <property type="protein sequence ID" value="KJB49782"/>
        <property type="gene ID" value="B456_008G137900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764045"/>
    <dbReference type="eggNOG" id="ENOG502QU0Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THISPLM"/>
    <dbReference type="OrthoDB" id="1927637at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.80:FF:000003">
        <property type="entry name" value="WRKY transcription factor 57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.80">
        <property type="entry name" value="WRKY domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017396">
        <property type="entry name" value="TF_WRKY_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003657">
        <property type="entry name" value="WRKY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036576">
        <property type="entry name" value="WRKY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044810">
        <property type="entry name" value="WRKY_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221:SF323">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31221">
        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03106">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038130">
        <property type="entry name" value="TF_WRKY_IIc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00774">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118290">
        <property type="entry name" value="WRKY DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50811">
        <property type="entry name" value="WRKY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="9">
        <location>
            <begin position="154"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="82"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="97"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB49782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0592552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="319" mass="35960" checksum="8E8C34FFC33B619E" modified="2015-04-29" version="1">MHTFMERKEGLKMEDYVMGNSINSNSSFCDYTGNGFPLQSVFDSCSEDDNNKFSLGFMELLGVQDFTCPLFDVAQQVPVSTKMESPEQGFNLPATPNSSSVSSGSSEAVNGEPVKVEDDQEEEDDQQKNKKQLKVKKANQKRQREPRFAFMTKSEVDHLEDGYRWRKYGQKAVKNSPFPRSYYRCTSTSCNVKKRVERCFTDPSIVVTTYEGQHTHPSPLMPRPNLVGSTINSGISAGAAAAFSVPMQRNTQSHYYYQQQQQHQHPFANSLSSLNFGHNGPSIDSSFLHERRLCTSGQSLLKDHGLLQDIIPSHMLKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUT4</accession>
    <name>A0A0D2PUT4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">histidine kinase</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_008G143100</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ethylene receptor family.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUT4"/>
    <dbReference type="STRING" id="29730.A0A0D2PUT4"/>
    <dbReference type="Gramene" id="KJB49872">
        <property type="protein sequence ID" value="KJB49872"/>
        <property type="gene ID" value="B456_008G143100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764096"/>
    <dbReference type="eggNOG" id="KOG0519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQEAHRY"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051740">
        <property type="term" value="F:ethylene binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038199">
        <property type="term" value="F:ethylene receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZ47</accession>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
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        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
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        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
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        <property type="entry name" value="PINORESINOL-LARICIRESINOL REDUCTASE 3-RELATED"/>
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            <end position="302"/>
        </location>
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        </source>
    </evidence>
    <sequence length="306" mass="34315" checksum="0FD7086F4EBA55E0" modified="2015-04-29" version="1">MEKSKVLIIGATGRLGYHLAQFSLQFGHPTYILIRDSSLNDPNKAQKLNFLSTAGAIPLKGSLEDENSLTEAVKQVDVVICSIPSKQALDQKLLLKVIKESGCIKKFIPSEFGVDPNKIQIYNLAHRFYAGKTEIRRLIEAEDIPYTYICCNLFMGYLLPSLAQPGLKAPPRDKVTIFGDGNAKAVFVKDVDVAACTINAIDDPRTLNKTLYLRPQGNVYSINELVAMWENKIGRELEKIHVPEEELLLKIKESSYPDNLEMIFIYSAFVKGDHTYFDIDECGVDGTKLYPHLKFTTVSEHLDTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q592</accession>
    <name>A0A0D2Q592_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G083400</name>
        <name evidence="4" type="ORF">Gorai_011389</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q592"/>
    <dbReference type="STRING" id="29730.A0A0D2Q592"/>
    <dbReference type="Gramene" id="KJB53458">
        <property type="protein sequence ID" value="KJB53458"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53459">
        <property type="protein sequence ID" value="KJB53459"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53460">
        <property type="protein sequence ID" value="KJB53460"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53462">
        <property type="protein sequence ID" value="KJB53462"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53465">
        <property type="protein sequence ID" value="KJB53465"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53466">
        <property type="protein sequence ID" value="KJB53466"/>
        <property type="gene ID" value="B456_009G083400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3XV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EGHEMID"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34564">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34564:SF3">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395342" evidence="2">
        <location>
            <begin position="23"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB53462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0594486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="108" mass="12793" checksum="71A054693BA4EBFE" modified="2015-04-29" version="1">MAISRPMLLVFLLLILIMTSQFEWRHQIVDFDMTPSVTPKQQQISRREEAVKEKIILSQEKNIQRLQELVRSLQQQLLQCKGNNKTNDTISHLTEHVLELERQQILED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5B3</accession>
    <name>A0A0D2Q5B3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G127900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q5B3"/>
    <dbReference type="STRING" id="29730.A0A0D2Q5B3"/>
    <dbReference type="Gramene" id="KJB14494">
        <property type="protein sequence ID" value="KJB14494"/>
        <property type="gene ID" value="B456_002G127900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R9NF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FVTFQAK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36398">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36398:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="273" mass="30138" checksum="03D89E5658D7C19B" modified="2015-04-29" version="1">MVYYFIHYNTTVKTIRLLASLSAMPPPMLRLISSTSVSTVAGLPPILTKPPISNQSLSINPSEENRQKVLRLISRRDAAFLSLISLFPSLLHTPHASAFSIGISGPKDWLKEQKRKSSKFLLAPIDASRQSLHSVYLLLMDKESTISNNDLEEVQKLLKSAARDCVVQERNSFVAFQANTGVEVCTFRLIVKNASSLLENKNPVKLEAEAMLDDLISMFCSSGVCSSFTSLNTLANESDIQVASSRQRVADALKDTITSLDKFEQGIKDCLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q9R5</accession>
    <name>A0A0D2Q9R5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knottin scorpion toxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G207400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB15984">
        <property type="protein sequence ID" value="KJB15984"/>
        <property type="gene ID" value="B456_002G207400"/>
    </dbReference>
    <dbReference type="OMA" id="KTACANK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249593" description="Knottin scorpion toxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8119" checksum="65B1844CAFC4CF60" modified="2015-04-29" version="1">MNKLQMSAILIVVILFAIGNEIMAQDGEGKLCAIPFNLPNCTDWVCKTACANKFPPNGYGMCQAGSTCLCFHPCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAZ6</accession>
    <name>A0A0D2QAZ6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G112500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QAZ6"/>
    <dbReference type="Gramene" id="KJB14036">
        <property type="protein sequence ID" value="KJB14036"/>
        <property type="gene ID" value="B456_002G112500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783223"/>
    <dbReference type="eggNOG" id="KOG0149">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIIVHSP"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12384">
        <property type="entry name" value="RRM_RBM24_RBM38_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000250">
        <property type="entry name" value="RNA-binding (RRM/RBD/RNP motifs) family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176">
        <property type="entry name" value="BOULE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11176:SF57">
        <property type="entry name" value="PROTEIN BOULE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="288" mass="31007" checksum="0383FEB5C81C13BA" modified="2015-04-29" version="1">MAFQQILGPSSGSSSSSGFQYMNSPFGDTTYTKVFVGGLAWETQSETMRRYFEQFGEIVEAVVITDKNTGRSKGYGFVTFRDPESARRACADPTPIIDGRRANCNLASLGRPRPPVPYGINSNLSGRLRPPSPYIGSVPRGAYVGSIGYQPPLPYNYQQGLMYPSYGYATYGPEYVYPQGAYNPYVAQQYLQIYGVPGAVNPVIYPYGQLGQTVPSGHGYTAVQGYAMPSHQIVQFGGAVANAITTSPMPTIQTPYPGGIAASVPTQPQFIVTTPQFMQGSGSDQTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QG30</accession>
    <name>A0A0D2QG30_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G244500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB38253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_006G244500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QWKIANI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF434">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE 13, PLASMA MEMBRANE-TYPE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB38253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="225" mass="24927" checksum="E30B76D869B8DDB6" modified="2015-04-29" version="1">MRFLATFFSDKTGTPTGSPMKVIKFWVGQQEVASSISPVVVYLTHEGVALNTTDSFGFSDCPKEKAILSWAEMDLKIDMEKTKKSCVLIRGAEVLDFEQKRSGVLIGRNNGDTLHVHWKGPAEIILAMCSSYYDASGVVKDLNDGERAKFEQIIQGMAASNLSCIAFAHKQVQEKEYDDLKEKKQVDGKSLTLLGVVGIKDPCKPGVKKQWKIANIFGSKHQNDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGB3</accession>
    <name>A0A0D2QGB3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydroxyproline O-arabinosyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G035500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGB3"/>
    <dbReference type="STRING" id="29730.A0A0D2QGB3"/>
    <dbReference type="Gramene" id="KJB06390">
        <property type="protein sequence ID" value="KJB06390"/>
        <property type="gene ID" value="B456_001G035500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771913"/>
    <dbReference type="eggNOG" id="ENOG502QQNK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10259977at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056508">
        <property type="entry name" value="HPAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044845">
        <property type="entry name" value="HPAT/SRGT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485:SF3">
        <property type="entry name" value="HYDROXYPROLINE O-ARABINOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31485">
        <property type="entry name" value="PEPTIDYL SERINE ALPHA-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23452">
        <property type="entry name" value="HPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Hydroxyproline O-arabinosyltransferase-like" evidence="8">
        <location>
            <begin position="67"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB06390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="361" mass="40740" checksum="3B8B924DE680D992" modified="2015-04-29" version="1">MGCGNVFFTLIITLSVALITYNILISANASLKQELPGPSTSSIIDPIIQMPVEKSRKYGSNAEKRLFHTAVTASDSVYNTWQCRVMYYWFKKHKNGPNSDMGGFTRILHSGKPDNYMNEIPTFIARPLPAGMDQGYIVLNRPWAFVQWLQKADIKEDYILMAEPDHIIVKPIPNLSKDGLGAAFPFFYIEPKKYELVLRKYFPEEKGPITNIDPIGNSPVIVGKDSLKKIAPTWMNVSLAMKKDPETDKAFGWVLEMYAYAVSSALHGVGNILYKDFMIQPPWDTEIGNKFIIHYTYGCDYNLKGKLTYGKIGEWRFDKRSFDTEAPPRNLPLPPPGVPESVVILVKMVNEATSNIPNWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QP02</accession>
    <name>A0A0D2QP02_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G035300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QP02"/>
    <dbReference type="Gramene" id="KJB21459">
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        <property type="gene ID" value="B456_004G035300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQSG">
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    </dbReference>
    <dbReference type="OMA" id="RIWRDKM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006957">
        <property type="entry name" value="EIN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33305">
        <property type="entry name" value="ETHYLENE INSENSITIVE 3-LIKE 2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33305:SF11">
        <property type="entry name" value="PROTEIN ETHYLENE INSENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="85" mass="10063" checksum="D8A8F5E42B2318B2" modified="2015-04-29" version="1">MDFFSAPLGEKDVAASQIEPEATVEDDYSEEEIDVDELERRIWRDKMRLKRLKEQNKCKEGIDIAKQRLSQEQARRKKMCGFSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QR35</accession>
    <name>A0A0D2QR35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G032400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QR35"/>
    <dbReference type="Gramene" id="KJB22159">
        <property type="protein sequence ID" value="KJB22159"/>
        <property type="gene ID" value="B456_004G032400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0701">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQTELYG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF51">
        <property type="entry name" value="RNASE III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14709">
        <property type="entry name" value="DND1_DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="3">
        <location>
            <begin position="69"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB22159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="314" mass="35441" checksum="23B4E122DB1E5C93" modified="2015-04-29" version="1">MEHHFTQLDDGASADVKPASNFGAAVATVLLALLLQIFWRCCRSICHNHVKKYKFSSSSAAANMDPSIIAAVEKILKYTFKDKRLLKEALTHSSCREDMSYERLEFIGDAALGLAVATYFFCWEPRLNPDQLTLFRIKSVSNERLALVAARHELDRFVRSKDTAPLNRNVREYVKAVKQGDDHKNLTVRSPDILAAIVEALAGAVYLDLNFDLTKLWTIFKDVLMIDEITVPNDFESSEINGAQTELYGLCGKRNWGKPVYSLVKADRCQYEMKYVYSVEVETDAGVCRHKGDEKSTPKDARNSAAYLLLRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QSJ7</accession>
    <name>A0A0D2QSJ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G188500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QSJ7"/>
    <dbReference type="STRING" id="29730.A0A0D2QSJ7"/>
    <dbReference type="Gramene" id="KJB10200">
        <property type="protein sequence ID" value="KJB10200"/>
        <property type="gene ID" value="B456_001G188500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS2Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF31">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="156"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="591" mass="68112" checksum="785B892CF37D90EC" modified="2015-04-29" version="1">MANHQRTSRIGVGGGGPMFGGFGFTVRLLASAITVALCFFFLLSFFFTSHSHSPHLQTNFGFSTGIGSTRRSVLALKSDPLKPRLDQIRKQADDHRSLVLAYASYARKLKLENSKIVRVFADLSRNYSDLISKPSYQALFETDSLSIDEPLLRQFEKEVKERIKATRQMISEAKESFDNQLKIQKLKDTIFAVNEQLTKAKKQGAFSSLIAAKSIPKSLHCLAMRLMEERISHPDKYTDEGKPMPPEFEDPKLYHYAIFSDNVLAASVVVNSATKNAKEPWKHVFHVVTDKMNLGAMQVMFKLKDYNGAHIEVKAVEDYKFLNSSYVPVLRQLESANLQKFYFENTLENATKDTTNMKFRNPKYLSILNHLRFYLPEMYPKLHRILFLDDDIVVHKDLTGLWKIDMDGKVNGAVETCFGSFHRYAQYMNFSHPLIKQKFNPKACAWAYGMNFFDLDAWRREKCTEEYHYWQNLNENRTLWKLGTLPPGLITFYSTTKPLDKSWHVLGLGYNPSISMDEIRNAAVVHFNGNMKPWLDIAMNQFKPLWSKYVDFDLEFVQACNFGDHQLQKSLFNKKFNLTLSKLLLFCVEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXK1</accession>
    <name>A0A0D2QXK1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G221500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXK1"/>
    <dbReference type="STRING" id="29730.A0A0D2QXK1"/>
    <dbReference type="Gramene" id="KJB43878">
        <property type="protein sequence ID" value="KJB43878"/>
        <property type="gene ID" value="B456_007G221500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804003"/>
    <dbReference type="eggNOG" id="KOG0817">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ECEKGIG"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF105">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="150"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB43878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="286" mass="31709" checksum="2B7E41973DA614D5" modified="2015-04-29" version="1">MELLLEFLFTLSLSFVLSFIIAKLLSLSSVIDQHLEAVSRCMEVPNKSEKCVLECEKGIGFVSEVVKFDALGESVEEKGTLEECLNDSHGPTKISEVTVEEISSGEENFGDKTTEIGLAEEDEEEIEVLEDCLNKGLSDDDWEGIERSELEKDFGAAVCFLESRNNADQILKLGDNLKMQLYGLQKVATEGPCLETHPMAFKLSARAKWNAWKRLGNMSPEAAMEQYITLLSRSIPGYGESKQHSADVKAPWKLPLDAKTMPANQAISVDSYRTFNEGTMSAVYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYC4</accession>
    <name>A0A0D2QYC4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G007500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYC4"/>
    <dbReference type="Gramene" id="KJB12230">
        <property type="protein sequence ID" value="KJB12230"/>
        <property type="gene ID" value="B456_002G007500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF9">
        <property type="entry name" value="DUF829 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="406" mass="45879" checksum="64EE67AC58D4DF72" modified="2015-04-29" version="1">MGGGGSVYWGRNQEESKQVKGIVVIFAWVSIHEKHLKNYLDFYSSLGWNSLVSRADFLNVYYPERAMSLAFVLLNELLEPYSVLGFQKLKIRTCPVVFVAFSGSPKACMYKVFQIIQETGEGRLNPLIRNCVCGQIYDSGPVDFASDLNARFALHPSIRKMPVPSKLVSWIAKGVASGLDGLYLTRFESQRTEYWETLYSSVDLDAPYLILCSEKDDLAPYPVIRDFTQCLQDLGADVEIVKWNGSPHLEHYKHYPIQYKAAVASFLEKTTLVYSRRIRNLREMNGMHDEISELIYGLQKAAVDSNQSFRRVALGPSDHFFLPSSAKYHNSRESGSLQDERPISLPVQPSINAHSVLGQILFDACVPKNIEGWDIRYSGSSKGQPFASARRRSPPLGIKCNRRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0I4</accession>
    <name>A0A0D2R0I4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G017400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
            <location evidence="1">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the C-terminally encoded plant signaling peptide (CEP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0I4"/>
    <dbReference type="Gramene" id="KJB63792">
        <property type="protein sequence ID" value="KJB63792"/>
        <property type="gene ID" value="B456_010G017400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SCXF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIMSGHK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005179">
        <property type="term" value="F:hormone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902025">
        <property type="term" value="P:nitrate import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901371">
        <property type="term" value="P:regulation of leaf morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000280">
        <property type="term" value="P:regulation of root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048364">
        <property type="term" value="P:root development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033250">
        <property type="entry name" value="CEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348:SF36">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33348">
        <property type="entry name" value="PRECURSOR OF CEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0052">Apoplast</keyword>
    <keyword evidence="5" id="KW-0372">Hormone</keyword>
    <keyword evidence="7" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250733" evidence="9">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB63792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="75" mass="8145" checksum="CC5C221E5AA47230" modified="2015-04-29" version="1">MAKNDILFVGALLFVLLFAYGVSFSEERVLKADHYEAFVADNVGTEYDTDDFRPTTPGHSPGAGHSTGPNSNDHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0U2</accession>
    <name>A0A0D2R0U2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G196300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0U2"/>
    <dbReference type="Gramene" id="KJB25529">
        <property type="protein sequence ID" value="KJB25529"/>
        <property type="gene ID" value="B456_004G196300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB25529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9360" checksum="C69813E0F0239E1C" modified="2015-04-29" version="1">MSVISWKSDGMVPVSAWLFKLACGAFFVGLDDLESVENRRGRSLSLEKWRRITDCERKCWNLTKYLIFEANFLIISAYCCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R4S8</accession>
    <name>A0A0D2R4S8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G267300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R4S8"/>
    <dbReference type="STRING" id="29730.A0A0D2R4S8"/>
    <dbReference type="Gramene" id="KJB26939">
        <property type="protein sequence ID" value="KJB26939"/>
        <property type="gene ID" value="B456_004G267300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793741"/>
    <dbReference type="eggNOG" id="ENOG502R8AM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEVGSCE"/>
    <dbReference type="OrthoDB" id="772776at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.80:FF:000003">
        <property type="entry name" value="NAC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF212">
        <property type="entry name" value="PROTEIN SOMBRERO-LIKE ISOFORM X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="7">
        <location>
            <begin position="8"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB26939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="389" mass="43878" checksum="4A7B98070C4BB99C" modified="2015-04-29" version="1">MGSTNGGVPPGFRFHPTDEELLHYYLTKKVSFQKFDMEVIREVDLNKMEPWELQERCRIGSSPQNEWYFFSHKDRKYPTGSRTNRATNAGFWKATGRDKCIRNSYKKIGMRKTLVFYRGRAPHGQKTDWIMHEYRLEDGDDPQGNPTEDGWVVCRVFKKKNLFKVSNTINGGSSLNSSDQHHHLNMNHTNTTSSSSQTQPPPPLSFMHRSNDQYNLNTTTTTTLELNKAELALHYPPHIPTPTHQYSLFHPQTLLPTHKSMTAYEYAPPLPVGLPSESSHPIMIKQLMSSNPRDCDSGSESVRYQCETGLEGVAAGGGGGSGRDDENEGMNEWGMLDRLVTSHMGIGQDSSSKGVRFEDSNNNGTNATSVHPINQLSLRGEMDFWGYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RBB6</accession>
    <name>A0A0D2RBB6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_005G085800</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="18">Serine/threonine-protein kinase that may function as a signaling receptor of extracellular matrix component. Binding to pectin may have significance in the control of cell expansion, morphogenesis and development.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RBB6"/>
    <dbReference type="STRING" id="29730.A0A0D2RBB6"/>
    <dbReference type="Gramene" id="KJB29124">
        <property type="protein sequence ID" value="KJB29124"/>
        <property type="gene ID" value="B456_005G085800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SNHTSVH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000043">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF511">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 19" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 21" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250061" description="Protein kinase domain-containing protein" evidence="21">
        <location>
            <begin position="25"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="23">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="418"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00058961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB29124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="26">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="748" mass="83370" checksum="2083B42F3846ADA0" modified="2015-04-29" version="1">MSSIRSLVLMQLMILLNVILTVKASTPAVAKPGCRSRCGDVIIPYPFGTGGDCNITAGFFINCNTSFIPHKPFFRNVEVINISTDGQLRILSNTSYDCYNTSYRNWLFYYFRLSEFLINNNKNKFTAIGCDTYAVVQQAGSYGQRYATGCLSLCNNITDVSNGSCSGIGCCQTSIPKDVRSYNISLDSYANHTNVLPENPCSYAFVAEVDSYTFSASDLRGFEFQSRQFPITLDWNIGNTSCNEANMDVNNFACKEYSKCVDSENNSGYFCKCLEGYVGNPYLPNGCQDINECESISPCNGTARCTNLLGTYNCSCPVGYEGDGKKSGTGCSLPNKDQSKTSPLIVALGVAIGFLGLLLGIVLWCWMLRQRQISKLREANFQQNGGILLREQLSKRQGYREDVKVFTAEELEKATNNYNESRILGQGGQGTVYKGILADNQIVAIKKSIIGDPSQVEQFINEIMVLYKINHRNVVKLLGCCLETQVPLLVYEYITNRTLFHHLHNDDATSYLSWETRLRIATETAEALSYLHSAASIPIIHRDIKLANILLDDNYTAKVSDFGASRLIPSDQAQITTIVQGTFGYLDPEYMLSSLLTEKSDVYSFGVVLMELLTGQKVVCFKRPEENRVLPMYFTSLMKEDRLLDILDPRVLNDENVEQLMEVATLARRCVRVKGEERPTMKEVAHELAGLQAMAKHPWSKSNLVSEESEYLLGKFPSTYDNGVTSSSIGMGYDSINNKITFELEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RD42</accession>
    <name>A0A0D2RD42_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G1173001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RD42"/>
    <dbReference type="STRING" id="29730.A0A0D2RD42"/>
    <dbReference type="Gramene" id="KJB27563">
        <property type="protein sequence ID" value="KJB27563"/>
        <property type="gene ID" value="B456_005G1173001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27564">
        <property type="protein sequence ID" value="KJB27564"/>
        <property type="gene ID" value="B456_005G1173001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27565">
        <property type="protein sequence ID" value="KJB27565"/>
        <property type="gene ID" value="B456_005G1173001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB27566">
        <property type="protein sequence ID" value="KJB27566"/>
        <property type="gene ID" value="B456_005G1173001"/>
    </dbReference>
    <dbReference type="OMA" id="PERDCKP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB27566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="135" mass="15749" checksum="751EC0B0AD0E36DB" modified="2015-04-29" version="1" fragment="single">MEEEKEKKRWSVAYTKHIKQKRKVYHDGFLDLHISSNKLMLYDESDKLLECRMLRRDEVVSSAQTLTFAAYFVDVGLLQSPYLNFSDARKKSNEVEPIDRSLSPSQKIIREFKKNELQKYVAQQTGPTTTKASVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDU4</accession>
    <name>A0A0D2RDU4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-galactose/UDP-glucose transporter 2-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G116300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. UDP-galactose:UMP antiporter (TC 2.A.7.11) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDU4"/>
    <dbReference type="Gramene" id="KJB49388">
        <property type="protein sequence ID" value="KJB49388"/>
        <property type="gene ID" value="B456_008G116300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763822"/>
    <dbReference type="eggNOG" id="KOG1582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YNRTTQF"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF8">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB49388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38416" checksum="3CC2AC4108D80D44" modified="2015-04-29" version="1">MKNEEQARFLFGISLSDLPKWKQFLICSSGFFFGYLVNGVCEEYVYNRLQFSYGWYFTFVQGFVYLFLIYLQGFTPKQMVNPWKTYVKLSAVLMGSHGLTKGSLAFLNYPAQLMFKSTKVLPVMVMGAFIPGLRRKYPAHEYISAILLVVGLILFTLADAQTSPNFSVVGVVMVTGALVMDSFLGNLQEAIFTLNPETTQMEMLFCSTVVGLPFLIPPMVLTGELFKAWNSCSQHLYVYGVLVFEAMATFIGQVSVLSLIAIFGAATTAMVTTARKAVTLLLSYLIFTKPLTEQHGTGLLLIAMGITLKLLPMPVDSKPGYKRVSSSVASEETRNGLEVEEKNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2REE4</accession>
    <name>A0A0D2REE4_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G127100</name>
        <name evidence="4" type="ORF">Gorai_009448</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2REE4"/>
    <dbReference type="STRING" id="29730.A0A0D2REE4"/>
    <dbReference type="Gramene" id="KJB49598">
        <property type="protein sequence ID" value="KJB49598"/>
        <property type="gene ID" value="B456_008G127100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763923"/>
    <dbReference type="eggNOG" id="KOG0028">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQDAEVW"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010091">
        <property type="term" value="P:trichome branching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044205">
        <property type="entry name" value="KIC/PBP1/KRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47319:SF4">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN KIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB49598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0592466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="123" mass="13747" checksum="FF72F5B4BA19B8FD" modified="2015-04-29" version="1">MENKGRTTTKNEYEDLLPVMAEKLDVEAFVSELCGGFRLLADEDRGLITAESLKKNSALLGMEGMSEEEAWDMVKEGDLDGDGALNQTEFCILMVRLSPGMMEDAETWLEKAIHQELRKKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGJ8</accession>
    <name>A0A0D2RGJ8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G0690001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB28741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="13" mass="1554" checksum="113B09627CEF9B14" modified="2015-04-29" version="1" fragment="single">MAEGQNEMQKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RK35</accession>
    <name>A0A0D2RK35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G101500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RK35"/>
    <dbReference type="Gramene" id="KJB71037">
        <property type="protein sequence ID" value="KJB71037"/>
        <property type="gene ID" value="B456_011G101500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776636"/>
    <dbReference type="eggNOG" id="KOG0167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YDICPRT"/>
    <dbReference type="OrthoDB" id="10064100at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16664">
        <property type="entry name" value="RING-Ubox_PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045210">
        <property type="entry name" value="RING-Ubox_PUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315">
        <property type="entry name" value="U BOX DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23315:SF240">
        <property type="entry name" value="U-BOX DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="7">
        <location>
            <begin position="264"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB71037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="759" mass="84525" checksum="5CD262101FFE156A" modified="2015-04-29" version="1">MGTEAVEAPSYPCSFQVHCLMCTELTKFVERIMNIFPEIEAARPRCSLGIKALCSLNSAIERAKLLLQYCSESSKLYLAITTDSMVARFQKIKNLLEQGLCQIQSMVPVTLVAEICQIVDDLRAANFVPDKFDEEAGKVVRELLHRGAAASDSMEYAEMKALQSAASRLHITSPKAILIEKRSIKKLLEKVSDCDQPKKKILKYLYYLLRKYANLIIGAQTDNERAFAVKSPSTSFTHARSANVEPHTEYKQSSVQADMLNRAIPPEEFKCPISSRLMYDPVVIASGQTFERTWIQKWFDDGNDTCPKTKMKLDHLSLTPNAAMKDLISKWCMKYKITIQDPSMQPDVLQSLETSSASIASFGISMNDLCFPVDISSISIGSLDTSYTSDGSHNRIAGGLSLMPEQTGDDCLQQQSVCSTRSKIDLECLSSLAMLDREAQYKMVEDKKNLLKCDDLDCVSLSSKNFIEPLLKFLSSAHDSHDIRAQKAGFQLLSTFLSKSRDGIRYLDQNAYSMLSLFIDSEVTREVLDIMEVLSEHSSCKSKISASGALVSMLNILDSNIKDFQDQIIKILSNLSSSSTDICSDLVSPECIPKLIPYLQDTSLAKHCIVVLRNLCNNQEGRTWITQTPGCIASIAMLLETGGFEDQENALAILLTLCSQSIEYCHLVMDECCIFPVLFDVSVKGNEKGKASALELLRLLRDTKHDADDDDADKQECSNSNDVESEDANNYSKDKVSHKILFGVKLPKFSRSTAPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RV39</accession>
    <name>A0A0D2RV39_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G006700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RV39"/>
    <dbReference type="STRING" id="29730.A0A0D2RV39"/>
    <dbReference type="Gramene" id="KJB33326">
        <property type="protein sequence ID" value="KJB33326"/>
        <property type="gene ID" value="B456_006G006700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798068"/>
    <dbReference type="eggNOG" id="KOG1289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFFWTWP"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="58053" checksum="1861079FFBC5C7FE" modified="2015-04-29" version="1">MEHNQQPTQFQEMDSGEKRLNELGYKQELRREMTLFKTLAISFSTMTLFTGITPLYGSSLQYAGPASLVWGWVVVSFFTCFVGVAMAEICSSFPTTGSLYFWAAHLAGPKWGPFSSWCCAWLETIGLIAGIGTQAYAGSQTLQSIILLSTGTNKDGGYFAPKWLFLCMYVSLTLIWAVLNTFALEVIAFIDIISIWWQVIGGLVIVIMLPLVAMTRKSAAYVFTSFEMGVDSTGVSSKPYAVILSFLVSQYSLYGYDAAAHLTEETKGADKNGPISILSSIGIIAVFGWAYILALTFSIKDFSYLYDPSNETAGAFVPAQILYDAFHGRYHNSAGAIVLLFVIWGSFFFGGLSITTSAARVVYALSRDKGIPYSSIWRQVHPKRKVPSNAVWLCAAICIVMGLPILKVNVVFTAITSICTIGWVGGYAVPIFARMVMPEKNFKPGPFYLGRARRPVCLVAFVWICYTCSVFLLPTYYPITWDTFNYAPVALGVGLSLVMVWWWVDARKWFKGPVRNIEISGNGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RXX3</accession>
    <name>A0A0D2RXX3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G175400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2RXX3"/>
    <dbReference type="Gramene" id="KJB36759">
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        <property type="gene ID" value="B456_006G175400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTGF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHEEAAS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35286">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35286:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB36759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="194" mass="22020" checksum="252CF84AE62321F7" modified="2015-04-29" version="1">MNSFSNTTNFDNLLLQTLLGRLQIRPTTTTSFLTQSLEDILLDAANFSDSDSDDTNKTQLAKEESKLEKEIIRIILSGKIDPLKPNSGQAVTINDHHICITSHKEKGSDYRVWEWHGHIMLFDEENGFTPEYIYGNYFERLQGKPLVSRAEEEKEEEEKVVNLGLRELIDGDAEPDTTGGRILHRNISASSPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S136</accession>
    <name>A0A0D2S136_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NusG-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G110300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S136"/>
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        <property type="protein sequence ID" value="KJB76852"/>
        <property type="gene ID" value="B456_012G110300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUSC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06091">
        <property type="entry name" value="KOW_NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09890">
        <property type="entry name" value="NGN_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF4">
        <property type="entry name" value="KOW MOTIF FAMILY PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="RHO-INTERACTING TRANSCRIPTION TERMINATION FACTOR NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="N-utilization substance G protein NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="4">
        <location>
            <begin position="107"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB76852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="352" mass="40042" checksum="E39FA2FD15E87306" modified="2015-04-29" version="1">MKQGLLLWSPCYLSPPSFHSISLKIPSIKHTPRLAPISASLDSTDTQVQLQQQLSARERRQLRNERRESKSGYSWREEVEERLIKKPKKRYTSWTEELNLDNLAHLGPQWWVVRVSRLRGLETAEVTARVLARNFPNIEFKFLFFSLQIYTPAVQEKKRLKNGSISVKPKPLFPGCVFLRCVLNKEIHDFIRECDGVGGFVGSKVGNTKRQINKPRPVSVDDMEAIFRQAKVEQEKSDQAFQEEQQGENALMSDKMNIEYNVDSNGVTSSVLDTKPKRQTKKKSDTVVNGAKYSKQLVPGSKVRVLSGNFAEFIGSLKKLNRKTGKATVGFTLFGKETLVDLDVKDVVLETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2U3</accession>
    <name>A0A0D2S2U3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_012G139000</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glucose(out) + H(+)(in) = D-glucose(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73203"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:73204"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sucrose(out) + H(+)(in) = sucrose(in) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:73211"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:73212"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2U3"/>
    <dbReference type="Gramene" id="KJB77472">
        <property type="protein sequence ID" value="KJB77472"/>
        <property type="gene ID" value="B456_012G139000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB77475">
        <property type="protein sequence ID" value="KJB77475"/>
        <property type="gene ID" value="B456_012G139000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779697"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VVCVIAW"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009705">
        <property type="term" value="C:plant-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000103">
        <property type="entry name" value="monosaccharide-sensing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000108">
        <property type="entry name" value="Monosaccharide-sensing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF35">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="687"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="7"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB77472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="740" mass="79116" checksum="D9A068CD00712CB8" modified="2015-04-29" version="1">MSGAVLVAVAAAIGNLLQGWDNATIAGAVLYIKREFSLESEPTIEGLIVAMSLIGATCITTCSGGISDWLGRRPMLIISSVLYCVSGLVMLWSPNVYILLLARLLDGFGVGLAVTLVPVYISETAPPEIRGLLNTLPQFTGSIGMFLSYCMVFGMSLSELPNWRLMLGVLSIPSLIYFILTIFFLPESPRWLVSKGRMIEAKKVLQRLRGREDVAGEMALLVEGLGVGGETSIEEYIIGPANEDIEDQDISDDKDQIKLYGPEEGLSWVARPVTGQSTLGIVSRHGSMASQSALGLVDPLVTLFGSVHEKVPETGSMRSALFPHFGSMFSVGGNQARNEEWDDDIVPREGEDYPSDGGGGDSDDNLHSPLISRQTTSLDKDIVPTNHGSLTSLRHGSLMQSTTGEQVGSMGIGGGWQIAWQLSEKVGPDGKKEGGFKRIYLHQEGVPGSRRGSLVSLPGNDAPVDSEYVQAAALVSQPALYASELMKQHPVGPAMIHPAETPKGPSWKDIFEPGVKHALVVGIGIQILQQFSGINGVLYYTPQILEQAGVGVLLSNLGISSSSASLLISGITTLLMLPSIAVAMRLMDIAGRRSLLLSTLPVLIISLLVLVIGSVVKMGNVVHAAISTVSVVLYFCFFVMGFGPIPNILCAEIFPTRVRGICIAMCALTFWICDIIVTYSLPVLLKSVGLAGVFGMYAVVCVISWVFVFLKVPETKGMPLEVITEFFSVGAKQVAAAKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S770</accession>
    <name>A0A0D2S770_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G208400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S770"/>
    <dbReference type="STRING" id="29730.A0A0D2S770"/>
    <dbReference type="Gramene" id="KJB37516">
        <property type="protein sequence ID" value="KJB37516"/>
        <property type="gene ID" value="B456_006G208400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PKNADNV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000416">
        <property type="entry name" value="p-loop nucleoside triphosphate hydrolase superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056653">
        <property type="entry name" value="DUF7751"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF76">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24933">
        <property type="entry name" value="DUF7751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="518"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB37516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="797" mass="89207" checksum="071A8DBDB025E133" modified="2015-04-29" version="1">MDQKHVLLSALGVGVGVGMGLGLVSGQSRLTGSGSAASTGLTLENMEKELIRQIVDGRESQVRFDEFPYYLSEQTRTLLTSAAYVHLKHADVSKYTRNLSPASKALLLSGPSELYQQMLAKALAHYFESKLLLLDVTDFSLRCFKRSPSESALERLSSRLKRQSSSVDIASRGNEGPPKLRRNASVSDNMNGLASKCSPANLAPMSRTSSLFFDEKLLIQALYKVLVYVSRATPIVLYLRDIDKLLFRSQRFYNFFQQMLKKLSGNVLILGSRVVDLGNDRELEERLAVLFPYNIEIRPPEEEQHLVNWKSLLEKDMNMIQTQDNKNHIIEVLSANDLDCDDLDSICIADTLALSRYIEEVVVSAISYHLMNNKDPEYRNGKLVISSKSLAYGLSIFQGKSIGNYRLKLEAPTETLKEAGTLSVGIKPESKSVIRTGNGTTNPEKTDGENSASVIKVPEVVPDNEFEKRIRHEVIPANEINVTFADIGALDETKECLQELVMLPLKRPDLFKGGLLKPCRGILLFGPPGTGKTMLAKAIAREAGASFINVSMSTIASKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLLTKPVERILVLAATNRPFDLDEAIIRRFERRIMVGLPGVENREKIFRTLLAKEKVEENLNFAELAAMTEGYTGSDLKNLCTTAAYRPVRELIQQERLKDMERKKKEAEGQNSDDPSTKNDDVEERVITLRPLNMEDLRQAKNQVAASFSSEGAGMNELKQWNELYGEGGSRKKEQLSYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S836</accession>
    <name>A0A0D2S836_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G210400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S836"/>
    <dbReference type="STRING" id="29730.A0A0D2S836"/>
    <dbReference type="Gramene" id="KJB27405">
        <property type="protein sequence ID" value="KJB27405"/>
        <property type="gene ID" value="B456_004G210400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050254">
        <property type="entry name" value="RNA_pol_beta''_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34995">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34995:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB27405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="274" mass="31324" checksum="66F62F51D414FD8F" modified="2015-04-29" version="1" fragment="single">IGSISLWVADTSIPLVRTCLVLSWDQDNKSSFAEEVCASFVEVRTNGLIRDFLRIDLVKSHIFYIRTRNDPSGSELISDNRSDRTNKNPQNHRTIHTLLNRNKESQSLIILSSSNCFRMAHSTISSIIRLWMSVAKYLELDNLKQAFQVLNYYLIAENGRIYKFDPCRNIFLNAVNLNWYFSHHHYHHNYCEEMSTIISLGQFICENVCIAKNGPRLKSGQIFIAQVDSIIIRSAKPYLATPGATVHGHCGEILYEGDTLVTFIYEKSRSGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S8Z6</accession>
    <name>A0A0D2S8Z6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alanine--glyoxylate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G006500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glyoxylate + L-alanine = glycine + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:24248"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="2.6.1.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.44" evidence="4"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S8Z6"/>
    <dbReference type="STRING" id="29730.A0A0D2S8Z6"/>
    <dbReference type="Gramene" id="KJB27700">
        <property type="protein sequence ID" value="KJB27700"/>
        <property type="gene ID" value="B456_005G006500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796307"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008453">
        <property type="term" value="F:alanine-glyoxylate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009853">
        <property type="term" value="P:photorespiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB27700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="483" mass="52874" checksum="A9A6FC5702A8D308" modified="2015-04-29" version="1">MRRFIPATAVLSEKTKYSLPLRRWRWRCFSQVAQKEFDNKGGVVVPKMPSFDYAPPPYTGPSAAEILSKRKEYLSPAMFYLYNKPLNVVDGRMQYLFDENGRRYLDAFGGIATVCCGHCHPHVVDAIVNQTKRLQHSTILYLNHAIADLAEALANKLSGNLKVVFFTNSGTEANELAIMMARLYTGCHDIISLRNAYHGNAAGTMGATAQSNWKFNVIQSGVHHAINPDPYRGVFGSEGEKYAKDIQDLIQFGTSGNIAGFISEAIQGVGGIIELAPGYLPAAYNIIKKAGGLCIADEVQGGFGRTGSHFWGFENHGVVPDIVTMAKGIGNGIPLGAVITTPEIAEVLTRRNYFNTFGGNPVCTAAGLAVLNVIEKEKLQDNAFVVGSYLKERLIALKDKHDLIGDVRGRGLMLGVELVTDHELKTPAKLETLHLLDQMKEIGVLVGKGGFYGNVFRITPPLCFTTEDADFLVDVMDYAMSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAY3</accession>
    <name>A0A0D2SAY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Son of sevenless</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G089800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAY3"/>
    <dbReference type="STRING" id="29730.A0A0D2SAY3"/>
    <dbReference type="Gramene" id="KJB80277">
        <property type="protein sequence ID" value="KJB80277"/>
        <property type="gene ID" value="B456_013G089800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPWS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESRWGFA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133:SF7">
        <property type="entry name" value="F26K24.10 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133">
        <property type="entry name" value="OS08G0107100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="35641" checksum="93CECA9D2A5C68C5" modified="2015-04-29" version="1">MVTPPPPLLKIDLWTIRSEYCRIIKAHSRHFLALSLLFLLPFSFFLSIYPFIAIEFYLSFLQQDPSIFPTKTFILNLLYTLPISIFSLLATGSITYSIFHGFYGRPIKLLSAIKAAFTSFFPLFSTCLMTQLIVSGISLILGLAFSAVVILGFQVRYPSPYFIFLCLVYVIILLFVVVHLQVNWIFAYVVVVVESSWGFEPLKRSRNLVKGMKGVALKIILFFGFFISINTWRSVMTYGDSAADKWTSWPFVLNIFVTSTFSMVFLFYNLAANTVFYIYAKALHGELAEDEEFAAKYVSLAVDDGKAPHVVSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SB85</accession>
    <name>A0A0D2SB85_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP1-interacting protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G050900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SB85"/>
    <dbReference type="STRING" id="29730.A0A0D2SB85"/>
    <dbReference type="Gramene" id="KJB28480">
        <property type="protein sequence ID" value="KJB28480"/>
        <property type="gene ID" value="B456_005G050900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUP9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERDTQNG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008:SF2">
        <property type="entry name" value="COP1-INTERACTING PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31008">
        <property type="entry name" value="COP1-INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1054"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB28480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1236" mass="136762" checksum="A9DA19A2ECE1A247" modified="2015-04-29" version="1">MKSSTQLDSAVFQLTPTRTRFELVISANGKSEKMASGLLNPFLAHLKIAQDQISKGGYSIILQPEPGIDATWFTKGTMERFVRFVSTPEILERVYTVELEILQIEEAIAIQSNNNIGLSAAAEEHHLKSSESIEGKRATLDSNEEKAIILYAPGARPPLANGSAVQEENPKVQLLKVLETRKTALQKEQGMAFARAAAAGFSIDDMAPLMSFSERFGASRLRDACVEFTELWKRKHETGQWLEIEAMSSRADFSAMKELKQAWPVISENNGKSGLQSSTDEKPPIDQQTPGRQEYSQAQFPCPLFPPWPIHSPPGGMPTFQGYAMQGMSYYPHYPGSSPFFQQPYPSMEDLSHNVGQRIQRRHSMDSQNGSEAWKLERAKPQDDVESENETSVSPKSRKKRSSSGKRQSGMVVIRNINYIASKKQNLSDSDSHSGPEMDEEDGNSVQKNSLRSSKGKRSQAKPVDTEETVSGKEIDGGHWQAFQNYLLKGAEEEERRANQRIFSAEKEVQEKRILNRVSEDPVVLGGQEMSQYEERNMTDMHRTSASSGRMLKASSNDQSLTSIKGGHSADDRNSVDGSHYTEIEGRRVYRSSTNDEFIVNRQQNTNSPSGRLAVNWFERSSNNINDDSYIVPFRSTSVPRVGTDDRNAIGMDSEFSLSLQKSGTASNRVGSQINYKTDDLTLIPERGMEIGSIGYDPALDYKIQVDAEYATSLDKKKKEGMKGSKTSEIWKSKLVADPSDKKKTVGPIRKGKPSKMSPLDEAKARAERLRTYKADLQKMKKEKEEAEIKRLEALKMERQKRIAARNSSNAAQPSTAMQNKKQLLLKISPSSHKGLKFTDAEPGLSSPLQRSIRITPVVSPASLKTPKPSKLNNGTNSGGNRLSKSVPSLPVQKKDIGSVTPDAKVSMARIRRLSEPKVSSSARVSSVKSRNSEPSPRRKAFRGPESRKISAIVNHDKSKIVSLPELKIKTTKAPNITHSNSGGKGMTQKVNRSVSSTTDVTELCKNLDKVSFNIDGDDSMIIEKTIVMLEQEKPSVPPVNSSEGTAAIQKGNDVGRKTKEVSDYPSTRAPVSSLNAGSLDHEHLTQQRSQAYEVQKVNVSNTEKEPSKFTSSSVTKKPYQAPLARVSSSEDPCSEVSDHAIAPPTRLQAASKESESVRARVADSKNLKLEKIPEVPDKHQVKESPKGIRRLLKFGRKNHSSATSEHRIESDSVGVNDSPADEFVTTAHLLVKFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBP5</accession>
    <name>A0A0D2SBP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G003700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBP5"/>
    <dbReference type="STRING" id="29730.A0A0D2SBP5"/>
    <dbReference type="Gramene" id="KJB39251">
        <property type="protein sequence ID" value="KJB39251"/>
        <property type="gene ID" value="B456_007G003700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1124">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1211">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000004">
        <property type="entry name" value="Outer envelope protein 64, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF5">
        <property type="entry name" value="OUTER ENVELOPE PROTEIN 64, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="55"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB39251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="614" mass="67709" checksum="BBB49303ABC76B99" modified="2015-04-29" version="1">MASHAANLWVLLGLGLAGIFLMTKRLKKTIKADFGAFIQKLELLPPPQPAPPKAPHPLTGLNFAVSDVFDIEGYVTGFGHPDWLKTHEPSTRTSPVVLALVEGGATCIGKTVVDELAYSIHGENKHYSTPTNPAAPARISGGSSSGAAVAVAADFVDFSLGIDTLGGIRVPAAFCGVIGFRPSYGVISNTGIIPVSSSLDTVGLFAKDPSTLRRVGLVLLQLPFSVQRNPKQILLADDCFELLKIPKDRISQVVTNSTEKHFGRQVLKHENLEKYFSSKVPSLKEFYSQKINGDSKISSLTLLANVAQILQRYEFKRTHGEWINSEKPVLDSAISAQINETLDMTDKEIEICKLVRTEMRLAVNNLLKDDGILVIPTTAYPPPKLGSKEIFSDDYQNRSFSLLSIASISGCCQVTLPLGYHDKCPVSVSFIARHGGDRFLLDTVQTVYSSLQEHADTVAKSKLSPNAVKQEHSAEAVKEKGNQAYKDKQWQKAIGFYTEAIKLSDNNATYYSNRAAAYLELGSFLQAETDCTKAISLDKKNVKAYLRRGTAREMLGYYKEAIEGEFLHFMFQVFCIVIFICKPLHLLDQSEMKTKDYDCSCPVWICMLFENFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHQ7</accession>
    <name>A0A0D2SHQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_005G1558001</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHQ7"/>
    <dbReference type="STRING" id="29730.A0A0D2SHQ7"/>
    <dbReference type="Gramene" id="KJB30700">
        <property type="protein sequence ID" value="KJB30700"/>
        <property type="gene ID" value="B456_005G1558001"/>
    </dbReference>
    <dbReference type="OMA" id="KYAMHEN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000343">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF861">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 14 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="1"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="276" mass="31362" checksum="7C3DE44D4507B800" modified="2015-04-29" version="1" fragment="single">LQHRNLVRLLGLSFAQKERILIYEFLPNSSLDNFIFDPVKCSLLNWEKRYKIIEGIAKGLLYLHEDSQYRIIHRDLKPANILLDEEMNPKISDFGMAKLFTVDQTRADTSKVVGTYGYMAHDYAWHGQYSVKSDVYSFGVLVLEIISGKKISSFSNQEVGDSLLTHAWRNWREGTPLEVVDPILRDGSRSEIMRCIHLGLLCVQDNIDSRPTMASVVLMLSSYSISLPVPSRPAFSMHSTMETETKSQSSSLSNQSKRENIQVSVNEASISELDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJT9</accession>
    <name>A0A0D2SJT9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G254100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJT9"/>
    <dbReference type="Gramene" id="KJB63378">
        <property type="protein sequence ID" value="KJB63378"/>
        <property type="gene ID" value="B456_010G254100"/>
    </dbReference>
    <dbReference type="OMA" id="QASHICR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022251">
        <property type="entry name" value="DUF3774_wound-induced"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12609">
        <property type="entry name" value="DUF3774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB63378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="71" mass="7780" checksum="D8EAAA4361242AE3" modified="2015-04-29" version="1">MEDQASKLKSNLSSLKNPSSPSSSSSSSKQASHICRTLNHGVLSKTTNHEKLKQAEESLRTVMYLSCWGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMR2</accession>
    <name>A0A0D2SMR2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G190100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMR2"/>
    <dbReference type="STRING" id="29730.A0A0D2SMR2"/>
    <dbReference type="Gramene" id="KJB43246">
        <property type="protein sequence ID" value="KJB43246"/>
        <property type="gene ID" value="B456_007G190100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0351">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000444">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002061">
        <property type="entry name" value="RecQ family DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF155">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="46"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="247"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="674"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="702"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="720"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="732" mass="81932" checksum="D1E765506E2678FF" modified="2015-04-29" version="1">MKKSPLPVQNLGAKGKQRKCGREALVKLLRWNFGHPDFRGNQLEAIEAILSGRDCFCLMPTGGGKSMCYQIPALAKTGIVLVISPLIALMENQVMALKEKGIAAEFLSSTQTSQLRNKIHEDLDRGQPSIRLLYVTPELIATSGFMSKLKKIHGRGLLNLIAVDEAHCISSWGHDFRPSYRKLSSLRNQLQDVPILALTATAIPKVQKDVIDSLNLQNPLVLKSSFNRPNIYYEVRYKDLMDDAYADLCDVLKSAGDVCAIVYCLERTTCDDLSTHLSKNGISCAAYHAGLNNKLRSSVLDDWICSKIQVVVATVAFGMGIDRKDVRIVCHFNIPKSMEAFYQESGRAGRDQLPSRSLLYYGVDDRKRMEFILSIAESKKLQSSDSQHGLSKKSTSDFNLMVEYCEGSGCRRKKILESFGEEVSASLCKKSCDACKHPNLVAKYLVELTTAIAVRQRNGFSKILSSSTDAFENENFSEFWNRNDEASGSEEDISDSEDGFEVAKGISRSKFSKKTGINEKIELLQRAEENYYRNKAHDKQANKPDKNAISGALRESSKQRLLDALKQAHQRLGDLKVDFEASSTILENECFKKYGKSGKSFYYSQVASKVRWLSTTSSAAEITNQIGTGITSPLENITRKEEPSRTVSAMLHDERKKEVNKVIGEQRCGDIESKTSVKASTPQMQTKLPAIPSFSQFVNSRKSKEMQQPKASEEKEHHHSPNKHTKKRMRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SN91</accession>
    <name>A0A0D2SN91_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">adenylate kinase</fullName>
            <ecNumber evidence="5">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_010G054600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="5"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SN91"/>
    <dbReference type="STRING" id="29730.A0A0D2SN91"/>
    <dbReference type="Gramene" id="KJB64578">
        <property type="protein sequence ID" value="KJB64578"/>
        <property type="gene ID" value="B456_010G054600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774117"/>
    <dbReference type="eggNOG" id="KOG3078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001694">
        <property type="entry name" value="Adenylate kinase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053021">
        <property type="entry name" value="Chloroplast_ADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018962">
        <property type="entry name" value="DUF1995"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509:SF6">
        <property type="entry name" value="ADENYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35509">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (DUF1995)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09353">
        <property type="entry name" value="DUF1995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1995" evidence="14">
        <location>
            <begin position="327"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB64578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="594" mass="66159" checksum="8C4B1CCE8F4F0988" modified="2015-04-29" version="1">MLATSSSSSSSTAISLHPLSNYNASATPSLNPSSLSFSSSYSYLSPLSFRLHSSKTHLRITPKKGLRVSCSTNEPLKVMISGAPASGKGTQCELIVQKFGLVHISTGDLLRAEVSSGTEIGNKAKEFMNSGRLVPDEIVTAMVTVRLSHQDAKEKGWLLDGYPRSFAQAQSLEELNIRPDIYIVLDVPDEILIDRCVGRRLDPVTGKIYHLKNFPPESEEIKARLVTRADDTEEKVKSRLEIYKQNAAAISSTYSSITNKIDGNRPKEMIFKDIDSLLSQLLKDKTVKSMKPVLQTESRLDQASSNQEKWRGIPTRLNNIPHSREIRNYFYDDVLQATQRAVNDGRTRLKVEINIPELNPEMDVYRIGTLMELVRVIALSFADDGKRVKVCVQGSMGEGALAGMPLQLAGTRKILEFMDWGNYGAMGTFIKIGSIGAKEVDEEDDMFILVAPQNAVGNCIVDDLRAMTDAAGKRPVILINPRLKDLPGSSGIMQTMGRDKRLEYAASFESCYFFRLLYYAGTQYPIMGAIRMTYPYDYELYKRVDEPSGKEKYVSLSTFKERPTIDEINDAFLGKPRNKDKKASGIWGFLSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SR88</accession>
    <name>A0A0D2SR88_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G029400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SR88"/>
    <dbReference type="Gramene" id="KJB33755">
        <property type="protein sequence ID" value="KJB33755"/>
        <property type="gene ID" value="B456_006G029400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798307"/>
    <dbReference type="eggNOG" id="KOG2933">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SWENFCQ"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF62">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21040">
        <property type="entry name" value="CEP104-like_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="2">
        <location>
            <begin position="71"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="327" mass="36259" checksum="E72493A452DAC79E" modified="2015-04-29" version="1">MMSGNALRDLNTLPASERKNDSSSKGNFTKTCNGNTIENVEELQKKNPSSVCINGGETINAAVEVANSEVEYIESENLGDLEDVNTCLEKLLPGLESKDWVLVVETLNNVRRLSIFHREEMHSMLGDLIPLVVKSLKNPRSAVCKTAIMTSADIFSAYNDDLIEFLDPLLVQLLLKSSQDKRFVCEAAERALEVMTTSVFPMSLLPKLQPYLKNRNPRIRAKASMCFSRSVPRLGVEGIQEYGIDKLIQVAASQLSDQLPESREAARTLLLELQTVYEKSNGLSTTIPEQPEMNSWEHFCQSKLSPLSAQAVLRVTNIAREGLVIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRJ3</accession>
    <name>A0A0D2SRJ3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">(+)-delta-cadinene synthase</fullName>
            <ecNumber evidence="3">4.2.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G036100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="4.2.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRJ3"/>
    <dbReference type="STRING" id="29730.A0A0D2SRJ3"/>
    <dbReference type="Gramene" id="KJB33880">
        <property type="protein sequence ID" value="KJB33880"/>
        <property type="gene ID" value="B456_006G036100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798382"/>
    <dbReference type="eggNOG" id="ENOG502QUH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NHINSMI"/>
    <dbReference type="OrthoDB" id="1936865at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047461">
        <property type="term" value="F:(+)-delta-cadinene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000007">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.130:FF:000001">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF9">
        <property type="entry name" value="TERPENE SYNTHASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="7">
        <location>
            <begin position="65"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="8">
        <location>
            <begin position="299"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB33880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="597" mass="69634" checksum="860E41C9E0B7CA5E" modified="2015-04-29" version="1">MASCMFNSFSICSFPVQSKWKHFSYHGSSFRRLNVSFASRCEATNKISVEDNIVIRRSADYHPPIWEYDYVQSLRNDFVQDESYKERSSKLKEDVRMMFENVVDPLEKLELIDTIQRLGLSYHFGDGIKKTLKNISIDRSSTVASNKDNLYATALEFRLLRQHGYKVNQDVFACFMDEVGDIKASHNQDCKGLLNLYEASYHLLEGETMLENARKLAAKLLKQCLKENNDHQYLWMLVEHALVLPLHWRMPRLEARWFIDVYEKKKDKNPIILELAILDYNIVQSMHQDDLRYASTWWKELGLGKTLSFARDRLMENFLWSVGMINTPQDGKGRRIQTKVNALITVIDDVYDVYGTLDELELFTDVVERWDINEIQKLPNYMKICYHALYNSVNEMAFDTLKEQGIDVLPFLKKVWTNLCKSYLLEAKWYYIGYTPTLREYIDNAWISISGSVMLGHSYLATDLITEEGLHHIQQYYPDMIYWSSIVVRLADDLGTSSYELQRGDVPKSIQCYMNESGASEEEARDHIRKLIDATWKKMNEDQMAKSPFSRTFIEVAMNLARISLLMYQNGDGHAIEDKETKDRVLSLFVNPIALPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SW16</accession>
    <name>A0A0D2SW16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FG-GAP repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G065200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SW16"/>
    <dbReference type="STRING" id="29730.A0A0D2SW16"/>
    <dbReference type="Gramene" id="KJB48369">
        <property type="protein sequence ID" value="KJB48369"/>
        <property type="gene ID" value="B456_008G065200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763250"/>
    <dbReference type="eggNOG" id="ENOG502QPN1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HVLICED"/>
    <dbReference type="OrthoDB" id="270568at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34284:SF1">
        <property type="entry name" value="FG-GAP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252093" description="FG-GAP repeat-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB48369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="697" mass="77492" checksum="9C00543D0BBDBCD4" modified="2015-04-29" version="1">MRKRDLAILMLSAFAIFFSLQHEGDFSFREAWYHLSDEYPIKYEAERLPPPLVADLNGDGKKEILVATHDAKIQVLEPHARRVDEGFSEAPLLAEVSLLPDKIRVASGRRPVAMATGVIDRIYKSGQPQKQVLVVVTSGWSVMCFDHNLTKLWENNLQEDFPHNAHHREIAISISNYTLKHGDSGLVIVGGRMEMQPHLYLDPFEEIGMAERSAEQHRRSANEKEASENSGTVNLRHFAFYAFDGRKGGLRWSRKNENIEEHSSDSSQLIPQHNYKLDVHALNTRQPGEFECREFRESILGVMPHHWDRREDTLLKLSHFKRHKRKTLKRVPGKSTTYPFHKPEEHHPPGKDDSKKISNLIGKAAKYASSAKSKKPMAYIPTITNYTQLWWVPNVVVAHQKEGIEAVHLASGRTVCKLHLQEGGLHADINGDGVLDHVQAVGGNGAEQTVISGSMEVLRPCWAVATSGVPVREQLFNASICHHSPFNLFQHGEFYRGFGRSSHVASLEVATPILIPRSDGHRHRKGSHGDVIFLTNRGEVTAYSPGLHGHDAVWQWQLLTDATWSNLPSPSGMMEGGMVVPTFKSISLRVHDNQQMILAAGDQTGVIISPGGSVLTSIDLPAPPSHALIAEDFSNDGLTDLILVTSSGVYGFVQTRQPGALFFSTLVGCLLLVMGVLFVTQHLNSMKGKPRASSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1M2</accession>
    <name>A0A0D2T1M2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G165300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2T1M2"/>
    <dbReference type="Gramene" id="KJB50349">
        <property type="protein sequence ID" value="KJB50349"/>
        <property type="gene ID" value="B456_008G165300"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502S5H6">
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34687">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34687:SF1">
        <property type="entry name" value="CHAPERONE PROTEIN DNAJ-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252216" evidence="1">
        <location>
            <begin position="28"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="10207" checksum="AC298E04570D6214" modified="2015-04-29" version="1">MVPIVLTQMATGLGVLAGAVFVKSVMDQKPMAGPFQRCPTCNGTGRVLCICSRWSDGDVGCRTCSGSGRRACSSCGGSGTGRPIPVQLIVRQPTNRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T3X0</accession>
    <name>A0A0D2T3X0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G071600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T3X0"/>
    <dbReference type="Gramene" id="KJB70408">
        <property type="protein sequence ID" value="KJB70408"/>
        <property type="gene ID" value="B456_011G071600"/>
    </dbReference>
    <dbReference type="OMA" id="WTTNKER"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB70408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="97" mass="11261" checksum="F66FF95CE708261F" modified="2015-04-29" version="1">MKNSHWTTNKERLAKANSKALYVIFCSVDQQEFKRVSNCIIVKESFALGEEYCNTKLVNNVLRSFPKIFFIEVTATKEAKNHEILKIDELIETLSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T483</accession>
    <name>A0A0D2T483_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G2113002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T483"/>
    <dbReference type="Gramene" id="KJB51309">
        <property type="protein sequence ID" value="KJB51309"/>
        <property type="gene ID" value="B456_008G2113002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="31" mass="3387" checksum="994199BFAE4FF2B3" modified="2015-04-29" version="1" fragment="single">MVCKLALCPAFQASGASNWTSRPTTNNLRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5Q0</accession>
    <name>A0A0D2T5Q0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-fructofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_008G236700</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; sucrose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.26" evidence="4"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5Q0"/>
    <dbReference type="STRING" id="29730.A0A0D2T5Q0"/>
    <dbReference type="Gramene" id="KJB51889">
        <property type="protein sequence ID" value="KJB51889"/>
        <property type="gene ID" value="B456_008G236700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765117"/>
    <dbReference type="eggNOG" id="KOG0228">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004564">
        <property type="term" value="F:beta-fructofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18624">
        <property type="entry name" value="GH32_Fruct1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000001">
        <property type="entry name" value="Beta-fructofuranosidase, insoluble isoenzyme CWINV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.560:FF:000002">
        <property type="entry name" value="Beta-fructofuranosidase, insoluble isoenzyme CWINV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021792">
        <property type="entry name" value="Beta-fructofuranosidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050551">
        <property type="entry name" value="Fructan_Metab_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31953">
        <property type="entry name" value="BETA-FRUCTOFURANOSIDASE, INSOLUBLE ISOENZYME CWINV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11837">
        <property type="entry name" value="INV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-fructofuranosidase N-terminal" evidence="15">
        <location>
            <begin position="18"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="13">
        <location>
            <begin position="121"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="14">
        <location>
            <begin position="442"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF11837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB51889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="649" mass="72424" checksum="260788661EFA1A45" modified="2015-04-29" version="1">MVDTRPFLPVSSHAGSDPTGPSENRRKPMKLQLSIFFVLLTVGFFAALLTSNNGSDNGFVKENEHGSLASPSSEKQLRPVSRGPAVGVSEKSNRLFAKDNENQLAYPWNNSMLSWQRTAFHFQPEKNWMNDPNGPLFYKGWYHFFYQYNPHAAVWGDIVWGHAVSKDLIHWLHLPLAMVADQWYDKNGVWTGSATILPDGKVVMLYTGSTTENVQVQNLAYPADHSDPLLINWVKYSGNPVLVPPPGILDKDFRDPTTAWLTSEGKWRITIGSKINKTGIALVYDTKDFIYYELLDGVLHAVPGTGMWECVDFFPVSKTEENGLDTSVNGPSVKHVVKASLDDDRHDYYSIGTYHEKNGTWIPDEPKIDVGIGLRYDYGIYYAAKTFYDQNKNRRVLWGWIGESDSEAADMQKGWASVQSIPRTILFDKKTGTHLLQWPVEEIESLRLKSYEFNQVKVQAGSVVPLDVGPATQLDIIAEFEIDKEALEKTTGSNVTFSCSSSGGTIERGALGPFGLLVLADDSLSEQTPVYFYIAKGSDGKLKTFFCNDQSRSSVASDVNKQIYGNLVPVLEGEKLSLRVLVDHSIVESFAQGGRTVITSRVYPTKAIYGAAKLFLFNNATEASVSASLRIWQMNSAFIRPYPNNKESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7P4</accession>
    <name>A0A0D2T7P4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Basic helix-loop-helix protein 110D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bHLH110D</name>
        <name evidence="10" type="ORF">B456_007G023500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0126558" last="E0126558">
            <title>The Basic/Helix-Loop-Helix Protein Family in Gossypium: Reference Genes and Their Evolution during Tetraploidization.</title>
            <authorList>
                <person name="Yan Q."/>
                <person name="Liu H.S."/>
                <person name="Yao D."/>
                <person name="Li X."/>
                <person name="Chen H."/>
                <person name="Dou Y."/>
                <person name="Wang Y."/>
                <person name="Pei Y."/>
                <person name="Xiao Y.H."/>
            </authorList>
            <dbReference type="PubMed" id="25992947"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KP698871">
        <property type="protein sequence ID" value="AKI33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T7P4"/>
    <dbReference type="STRING" id="29730.A0A0D2T7P4"/>
    <dbReference type="GeneID" id="105801914"/>
    <dbReference type="Gramene" id="KJB39650">
        <property type="protein sequence ID" value="KJB39650"/>
        <property type="gene ID" value="B456_007G023500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801914"/>
    <dbReference type="eggNOG" id="ENOG502QT7W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054502">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025610">
        <property type="entry name" value="MYC/MYB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF3">
        <property type="entry name" value="TRANSCRIPTION FACTOR EGL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14215">
        <property type="entry name" value="bHLH-MYC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22754">
        <property type="entry name" value="bHLH-TF_ACT-like_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="8">
        <location>
            <begin position="420"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AKI33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB39650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="624" mass="69892" checksum="5D3971CEC5E135AD" modified="2015-04-29" version="1">MATTGVQNQEKVPMNLKQQFALAVRNIQWSYGIFWSISAKQPGVLEWGDGYYNGDIKTRKTVQSFEPKADDQLGLQRSEQLRELFESLSAGETSPHTKRPSVALSPEDLTATEWYYLVCMSFVFNIDQGLPGRTLSIGQPIWLCNAQYADSKVFSRSLVAKSASIQTVVCFPYAGGVIELGVTDLVLKDLGLIHRVKSLLLDAPETITGNINDVACPGLGPNEIESELSPFLGCEQLERGSPNEISDGFEPNQPAEDPFVNGGASQVQSWQFMDDHHSLNTSDCISQTFSDHEDVVPLCQGENDNDNDFRDVEECDRINRAAFDPISDDMHYRTVVSVLLKSSHQFILGPHFGNSNKESGFISWKMNSSVKYRKAKVEIPQKLLKKMLFEVPRMHDKGLLKSPQGGDGVGDAVWRPEADELCKSHVLSERRRREKINERLMILKSLVPTNSKADKVSILDDTIEYLQDLERRVEELECCRELTESETKTKQKHHRDRAERTSSNKVTNGNKSASSNKRKAYDIEETKQDIDHVASKDGSTENLTVSTNNKDLTIEFKCRWRDGILFEIMDALSVLDLDCHSVQSSTIEGILSVTIKSKYKGSSVAKPGTIKQALLQKVQSLTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TBL1</accession>
    <name>A0A0D2TBL1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G239200</name>
        <name evidence="4" type="ORF">Gorai_010316</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TBL1"/>
    <dbReference type="STRING" id="29730.A0A0D2TBL1"/>
    <dbReference type="Gramene" id="KJB51931">
        <property type="protein sequence ID" value="KJB51931"/>
        <property type="gene ID" value="B456_008G239200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765146"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RICVHEM"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11073">
        <property type="entry name" value="CYP76-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000067">
        <property type="entry name" value="Cytochrome P450 - like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951:SF3">
        <property type="entry name" value="CYTOCHROME P450, FAMILY 706, SUBFAMILY A, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47951">
        <property type="entry name" value="OS08G0547900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0349">Heme</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0593371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="502" mass="56173" checksum="A9581C998F9F83F9" modified="2015-04-29" version="1">MALLFTFVIASSILWLTWIYLKSKKGKPPPPPGPLGLPLVGNLPFLRPDLHSYFSELAHIYGPVVKLQLGSKLAILITSSSTAREVLKDQDIAFANRDVPVVAKVLTGGRDIVWNPYGPEWRMLRKVCVIKMLSNATLDKVYSLRRQEVRETLGYLYSKAGSPVNVGEQMFLTILNVLTNMLWGGSMEGEARASLGAEFRQVISEVTELLGLPNVSDFFPALAPLDLQGAVKRIRKPAEKLDAIIDKIINQRLEEKQSGHTVEEFKDFLQFLLKLKDEDDSKTPMTMTHIKALLLDMVVGGSDTSSNSIEFTMAEIINKPEVMRKAQQELDEIVGKDNFVEESHIHKLPYLLAVMKESLRLHPVLPLLVPHCPSEPSTVGGYAIPKGSRVFVNAWAIHRDPSIWENPLEFNPDRFLNSQWDFSGSDFRYFPFGSGRRICAGIAMAERMVLYSVASLLHSFDWQVPGGEKLDLSEKFGIVLKLQNPLVAIPTPRLSDPALYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TDC0</accession>
    <name>A0A0D2TDC0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G114200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TDC0"/>
    <dbReference type="STRING" id="29730.A0A0D2TDC0"/>
    <dbReference type="Gramene" id="KJB41655">
        <property type="protein sequence ID" value="KJB41655"/>
        <property type="gene ID" value="B456_007G114200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSHQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSIRWYS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.330.10:FF:000002">
        <property type="entry name" value="B3 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044800">
        <property type="entry name" value="LEC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR ABI3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31140:SF123">
        <property type="entry name" value="B3 DOMAIN-CONTAINING TRANSCRIPTION FACTOR NGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252480" description="TF-B3 domain-containing protein" evidence="7">
        <location>
            <begin position="31"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="TF-B3" evidence="8">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB41655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="421" mass="47771" checksum="35658F58A3DC14C3" modified="2015-04-29" version="1">MNTSKKPLFAEGNFWWWWVILMNFVQDEDHEENDDEVTRENTSNFPFSSSSSSATSNNKDTVAQQHQKHLWLGTLDSREDYKVQVPAIKFDKKLGQMDLSLGNNNEYQSNIGSCIGGDSGSTIRCIEKEHMFDKVVTPSDVGKLNRLVIPKQHAEKYFPLHSSTNEKGLLLNFEDRNGKSWRFRYSYWNSSQSYVMTKGWSRFVKEKKLDAGDTVSFQRGVGESGKHRLYIDWRRRPNAPDPTTLAHIQLQSQFNFPHSVRWGSLYSMPQPMCVPRNYEPLHRLNYSIYPNTHRQRQAITYGNAGQYYPRSSSGSHHHQIGAVQAGGAEPMVIDSVPVVQGNKTVAKRLRLFGVNLECPNTTQAESSSGFPHGTIGSDDSPHFSSFSRQSTLSNNNTLRQSGMQAEYSKKGKSSLSIDLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGS4</accession>
    <name>A0A0D2TGS4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G002900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGS4"/>
    <dbReference type="STRING" id="29730.A0A0D2TGS4"/>
    <dbReference type="Gramene" id="KJB53736">
        <property type="protein sequence ID" value="KJB53736"/>
        <property type="gene ID" value="B456_009G002900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768833"/>
    <dbReference type="eggNOG" id="ENOG502QU30">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEANHNC"/>
    <dbReference type="OrthoDB" id="191334at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044174">
        <property type="entry name" value="BC10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003406">
        <property type="entry name" value="Glyco_trans_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042">
        <property type="entry name" value="CORE-2/I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31042:SF150">
        <property type="entry name" value="OS06G0661900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02485">
        <property type="entry name" value="Branch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB53736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="44259" checksum="EC8BC277C3E7557A" modified="2015-04-29" version="1">MGGDMQMLPGSSHRPALKRPVWIIFFVSLVSLFLACSYIYPPHGDAACYVFSSKGCKAVTDRPLPSPARELTDEEFASKVVFRDILHIPRIQPKYSKIAFMFLTPSSLPFEKLWDRFFCGHEGKFSVYVHASKEQPVHVSRYFLNREIHSDKVGWGKISMVDAERRLLAHALKDPDNQQFVLLSESCIPLHSFDYVYDYLMHANMSFVDCFFDPGPHGHGRYSKHMLPVVEKKDFRKGAQWFSIRRQHALVVMADSLYYSRFRDYCKRGFDGKNCIADEHYLPTFFHIIDPGGIANWSVTHVDWSERKWHPKSYRARDVTYELLKNITSIELSVHVTSDEKREEQVQACLWNGVRRPCYLFARKFYPETLHKLMKLHNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJ64</accession>
    <name>A0A0D2TJ64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PdxS/SNZ N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G134000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Scheffler B.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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                <person name="Roberts A.W."/>
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                <person name="Wang Z."/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2TL26"/>
    <dbReference type="STRING" id="29730.A0A0D2TL26"/>
    <dbReference type="Gramene" id="KJB57429">
        <property type="protein sequence ID" value="KJB57429"/>
        <property type="gene ID" value="B456_009G163600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769359"/>
    <dbReference type="eggNOG" id="KOG0167">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLMDTMN"/>
    <dbReference type="OrthoDB" id="777117at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46700">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46700:SF2">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB57429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0595120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48492" checksum="B0EAD932003624EA" modified="2015-04-29" version="1">MFPSQVQTLNMSTTSSSSIWLLSCRKLKFFTRIRRFLHSKAARKQYGSSASDHSNKLRIVNNTDEEEDLVVEKTESELDGSMALQKSVKRLHFGSWEEKEMAAKAIEKLAKEDVKVRKLMAELGVIHMLVSMVDTEVVGRRLAAIKALIELADGTFTNKELMLEAGILSKLPKHIDAVDDQTRHEFAELLLSLSSISNTPFSLANTEVLQFLIAILESATSIETKETCLGVACNLSAVLENARPLVSNGTVHTLLKLSSFKELSEKALAALGHLVLTLMGKKAMEDSSMVPESLIEILTWENKPKCQELSAYILMILAHQSSTQRDKMSKAGIVPVLLEVSLLGSPLAQKRAMKLLQWFKDERQAKMGPHSGPQTARIAIGSPLHPREAQEGKKMMKNLVKQSLHKNMEMITRRANAAGDSSNLKSLVLSTSSKSLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TS44</accession>
    <name>A0A0D2TS44_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G356400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TS44"/>
    <dbReference type="Gramene" id="KJB46280">
        <property type="protein sequence ID" value="KJB46280"/>
        <property type="gene ID" value="B456_007G356400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB46280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="99" mass="11325" checksum="0C302CE78C9BB268" modified="2015-04-29" version="1">METKFSSSNNPECVLVVGFQMKYFLCDTWSKHASTLVGEQDSLLLVDWLPHPFLQYRTLALGIETLLLVKHNQSLLVSPIFGKLPKEKVKRFSTTHHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TT62</accession>
    <name>A0A0D2TT62_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Knottin scorpion toxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G016100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TT62"/>
    <dbReference type="Gramene" id="KJB78753">
        <property type="protein sequence ID" value="KJB78753"/>
        <property type="gene ID" value="B456_013G016100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252023" description="Knottin scorpion toxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8305" checksum="943DBFFC64007665" modified="2015-04-29" version="1">MAKMKILSFILILVLVLSIENMGVVGDGCCTDYHRGPCEHGKDDAAPDGSCFKFCTTQQFCRDALCKNNNVCHCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U053</accession>
    <name>A0A0D2U053_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G349100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U053"/>
    <dbReference type="STRING" id="29730.A0A0D2U053"/>
    <dbReference type="Gramene" id="KJB61276">
        <property type="protein sequence ID" value="KJB61276"/>
        <property type="gene ID" value="B456_009G349100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766174"/>
    <dbReference type="eggNOG" id="KOG1769">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPPDDVC"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="27"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="115" mass="12611" checksum="85A87FCDA5701082" modified="2015-04-29" version="1">MPRFAAAGSSGGDDKALTTADGQSQIIQVCVKSQDGNKVVYNIKRNAKLIKLMHAYCRKKQLDIHTVRFIYEGHRVPGKYTSDELNLEDGAEICCMFHQSGGGVCSMPKITSAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U176</accession>
    <name>A0A0D2U176_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_009G369800</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U176"/>
    <dbReference type="STRING" id="29730.A0A0D2U176"/>
    <dbReference type="Gramene" id="KJB61611">
        <property type="protein sequence ID" value="KJB61611"/>
        <property type="gene ID" value="B456_009G369800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDNSMIC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000101">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF583">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="821"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="23">
        <location>
            <position position="849"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1107" mass="123304" checksum="13AA95F8CEAA7ADB" modified="2015-04-29" version="1">MTARNLNSDQFALLKFKDRIADPQNVLANNWTASTSVCRWIGVSCGIIHKRVIALNLSSMNLRVTIPPYLGNLSFLLSLDLNHNSFYGLLPKELGQLHRLKILQLSFNSLNGEIPSWLGNLHKVQRLQMTNNTFTGTIPQTLVNMSNLEIFNLIFNQLSGQVPSSIFNISSLKIITLSGNSLSSSLPNDMCQHLPKLKGLYLSWNEFSGNIPSSIDKCNNLKNLSLSYNQFVGIIPRSIGNLSRLEELYLGFNNLEGQIPKEIGNLLSLEMLSIQAIKGLTGPIPSPIFNISSLKAIGLSENNLSDSLPNDVCQHLPKLEGLDLISNELSGNIPSSIGKCNNLRILSLSINKFTGIIPRSIGNLTQLEELYLALNNLEGNLPSMTNALKLEYLILRGNKLSGNIPNSISNVSMLKFLDLVDNLFSGPIPKTLGNLRHLERLQIMNNNLITGSADHEWTFLSSLTNCRHLRKIVVSGNPLSGVLPTYIGNLSTSLQRFYADHCELEGNIPMQIGNLSNMLVLELGYNKLSGFIPTSIGGLRNLQGLGLFSNKLEGPISESLCDLERRYNLFLGLNKLYGSIPSCFGNITSLRYLYLESNKLSSAIPSTLWNLNDILEVDLSSNYLDNSHALDVGDLRSLLKLNLSRNILTGDILSTFGGLKTLVSLDLSNNILHGVEIGQPCFCLKCMQLNDMLQHSLEKLLYLKYFNVSFNRLEGEIPIEGCFSNFSSTSFMKNYALCGPPRLLVPPCKNDIHKNSKMTLLHAFRYGLPTIGIVIVLIVLTIIYRRCQSRGTTLPIRDDLLSLKTLRRISYYELSQATNGFEECNMLGFGSFGYVYKGRLSDGMEVAIKVFNLQIEGAFQSFDIECDAMRNIVHRNIVKVINCCSSVDFKALVFDYMSNGNLEKWLHSNNCFLDIIQRVNIMIDVAAAVEHLHNEHPTPIIHCDLKPSNILLDEDMVAHVGDFGIAKLLGEGDVMKQTMTLATIGYMAPEFGSTGIVSIKCDVYSYGIILIETFTKKKPTDNLFAEEVTIRHWMECSLPKGAIEIADADLLREEDEYFVVKANCISAIMELALNCSAELPEERKDMKDVVVELKKIKQRLLNNIKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4J8</accession>
    <name>A0A0D2U4J8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G168700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2U4J8"/>
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        <property type="protein sequence ID" value="KJB50395"/>
        <property type="gene ID" value="B456_008G168700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50396">
        <property type="protein sequence ID" value="KJB50396"/>
        <property type="gene ID" value="B456_008G168700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
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        <property type="term" value="P:mitochondrial mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF182">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="241"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="379"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="414"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
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        </location>
    </feature>
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            <begin position="589"/>
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        </location>
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            <begin position="624"/>
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        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="659"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB50395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U558</accession>
    <name>A0A0D2U558_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G029900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_010G029900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB64024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="150" mass="17640" checksum="1C21859988CFC0F6" modified="2015-04-29" version="1">MSPKCLLDSPFIWGDTDKCRFLINVDYLLKRGVFELNNFNYSLDKCLDENLSNWVHALYNKPVLYKVNDYSRKSYELLSAAAVVRFCSNIFQHYNEYADECGERKIGKIRIVRKLSEALPNLFVDLFDGYINHAYCLEELYEPDVHEAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8A6</accession>
    <name>A0A0D2U8A6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G232700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2U8A6"/>
    <dbReference type="Gramene" id="KJB51810">
        <property type="protein sequence ID" value="KJB51810"/>
        <property type="gene ID" value="B456_008G232700"/>
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:response to stress"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
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    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF499">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="320" mass="35979" checksum="0A474A568EB83BE2" modified="2015-04-29" version="1">MESSSEVSSRLQYIEQYLLDENQFPPVGLWSFLNENQWTNYPKSEVSTSQSHSLYSQTSTSDSCLTASNFNSLDEDDFFNFSTSFPGFESNHSDVFEFDSKPQFIHLTTPKPLTSDATACEFQVKSRSSSNSTSNSQSRKPSLKISLPHKVEWIQFGKPDLTEVKPKNSNTEERSKHYRGVRQRPWGKFAAEIRDPNRKGSRVWLGTFDTAIEAAKAYDRAAFKLRGSKAILNFPLEAGKLDVIAADGERKRSRDDGAGDEREVKAVKRVNDDVTKARDNGDAPLTPSNWTSFLDCDNDTKGLFNMPLLSPLGLHQVIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U8K3</accession>
    <name>A0A0D2U8K3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G039400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB64246">
        <property type="protein sequence ID" value="KJB64246"/>
        <property type="gene ID" value="B456_010G039400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYADRFN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000022">
        <property type="entry name" value="F-box protein FBW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF80">
        <property type="entry name" value="F-BOX DOMAIN, LEUCINE-RICH REPEAT DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB64246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="29172" checksum="3217275EAD9D0448" modified="2015-04-29" version="1">MEEEQSEFRHWDELLPDVLGLIFTNLSLQELLTIIPCVCKSWRKTVGDPHCWQDIDLDEWSCRWQPHQLDRMLRMLVRRSSGSLRRLHVSGLKNDSIFSFVTENAGSLQVLRLPHSKISDSIVEQTAPRLSTVTFLDLSYCPKIGAQAIEAIGKHCKLLVTLCRNMYSSDSAGKVEPEDEANAIAATMPRLKHLELGFHLISTECVLNILSSCPQLKHLVIDGCPQVKLDRKFLKEKYPKLKTGEALHLWSSTVPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA97</accession>
    <name>A0A0D2UA97_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G265200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA97"/>
    <dbReference type="STRING" id="29730.A0A0D2UA97"/>
    <dbReference type="Gramene" id="KJB52500">
        <property type="protein sequence ID" value="KJB52500"/>
        <property type="gene ID" value="B456_008G265200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765411"/>
    <dbReference type="eggNOG" id="KOG2761">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WAGLICL"/>
    <dbReference type="OrthoDB" id="1295045at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08870">
        <property type="entry name" value="START_STARD2_7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.530.20:FF:000006">
        <property type="entry name" value="StAR-related lipid transfer protein 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF52">
        <property type="entry name" value="POLYKETIDE CYCLASE_DEHYDRASE AND LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="131"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB52500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="411" mass="46626" checksum="6F5D69E974A3A560" modified="2015-04-29" version="1">MLYLVPFWIAFLVGILVGWAWKPKWAELLTQKLSSVVSKSLELSLPSSSSMSPMFCLKNFGSSSCLNSLNLQPEAWVIDNGEQGKTLSVSPSEYDNSSTSRSVVNEGCSSAITEEDLKHLCQLVEMRDGGPTWMHMMDRSTPNMSYQAWRRDPKTGPPQYRSRTVFENATARIVRDFFWDDEFRPKWDHMLAYSATIEECSTTGTMVVRWIRKFPFFCSDREYIIGRRIWEVDGSYYCVTKGVTCASVPRRNKPRRVDLYYSSWYIRAVESRRGNGQLTACEVLLFHHEDMGIPWEIAKLGVRQGMWGTVKKIKPGLCAYQKERESLASLSQSAYMAQVNTKISMEYLISLESNEVLSRSDVDSTSENPLAQNISRALIYGGLIVLACSLDHGALSKTFIFGMGRKLTDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UB75</accession>
    <name>A0A0D2UB75_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_010G086300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UB75"/>
    <dbReference type="STRING" id="29730.A0A0D2UB75"/>
    <dbReference type="Gramene" id="KJB65246">
        <property type="protein sequence ID" value="KJB65246"/>
        <property type="gene ID" value="B456_010G086300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB65252">
        <property type="protein sequence ID" value="KJB65252"/>
        <property type="gene ID" value="B456_010G086300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773066"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHNAKHL"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="246"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB65246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="337" mass="36922" checksum="9DF859A3F86611E9" modified="2015-04-29" version="1">MSYMAVRVQSLSKKNFDERFSILSLPHMSVGFQPWWNSNEQKIAHSLPQNISLKVETPSKLHHNAKHLDHQLPDQESTSAQAICQSRPEMGVTRGSNPSFYSSDFGQDESCGKDIEGQMKPINNPNTVFSPSNPNYNLSMASAQYPYADVCIGGLFTPYGQPAIIQAQMAGGSAPARLPLPLDLAEDGPVYVNAKQYHGILRRRRYRAKLEAQNKLVKSRKPYLHESRHLHAVNRVRGSGGRFLSKKKLQQPHHPTSNPSSRSISDASCLDRKNSGSELESHLHGGGCSSSSTSCSDISSASNNNGSFQLRKHGFMDISPGVSSMCNGLQNCASVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UEE3</accession>
    <name>A0A0D2UEE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G178000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UEE3"/>
    <dbReference type="STRING" id="29730.A0A0D2UEE3"/>
    <dbReference type="Gramene" id="KJB67154">
        <property type="protein sequence ID" value="KJB67154"/>
        <property type="gene ID" value="B456_010G178000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GDELHCA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF4">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="10">
        <location>
            <begin position="35"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB67154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="331" mass="36869" checksum="D09543666B5A148E" modified="2015-04-29" version="1">MGYFFEELTTALRDYVRRETLLYFAQWLTYHYKNSKGEGPEIYLKREDPNHGSTYKINNAIAQAMIAKWMGWNSILAGTRAVQHEVVIATTFVKLSLDCTIFMQSTDMEKQASNVLLMKHLRAEVESIDGTFKDGSSEAIRALMGNLETKYYLAEKTVGLHPCPSMGGRLDILVACIGSGSNALGLFHEFINDEDVRLIGVEAAGFELNNVGVYHGVMSYLLQDEEGQILGPHSIGVGLKYPGVGPNVRFLKEIGRAEFHTTTSEEAVATYRQLCQLEGIFQALEASHALAFLEKLCPTLPNGTKVVVNLSSRRDKDATIVFQYQPDQLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKB2</accession>
    <name>A0A0D2UKB2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_011G005600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the terpene synthase family. Tpsa subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKB2"/>
    <dbReference type="STRING" id="29730.A0A0D2UKB2"/>
    <dbReference type="Gramene" id="KJB69109">
        <property type="protein sequence ID" value="KJB69109"/>
        <property type="gene ID" value="B456_011G005600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SHPY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000007">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF93">
        <property type="entry name" value="ALPHA-HUMULENE_(-)-(E)-BETA-CARYOPHYLLENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="6">
        <location>
            <begin position="73"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="7">
        <location>
            <begin position="288"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB69109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="584" mass="67338" checksum="479BAD5FE354EB58" modified="2015-04-29" version="1">MTVQVQGSGNTNILLCLSKAPSPPFPMLFPLRLHKAKRCCFVAAHSTSSTKATPLSSNHRESGRPLANFPPDIWGDHFLTLSFDISELDRCSTQIEVLKEMVKDMLMTSTTDPLHNILLINSLCRLGVSYHFETEVEQQLTRCFDTLSQLIHNNDYNLHETAIMFQVFRSHGYNMSSDIFNKFKKRNCEFKISDIKEMITLYEAAQFKINGEFILDEAFNFTTTQLKSIVSQASTHYAQYIENALNCPYQKGMKMKQGIIHLKFAKYDFNRIQMMLQQELSSLCSEWKEENMESRFPYARQRIVESFFSATVFYFEPCYARARNIYAKLLSTLAFIDDTYDAYGTYEELQHFTDAMQRFDISVIDELPTDYLKLLYETTLNVHNEIEDKVGKEGRSYAVSYTKNELKEVALAYLVERRWVHGCYMPTFDEYPETALKTCVAILSVCQALVGMEEADETAYQWLINTDNKLHKALNIIARLYDDIATNEAEEKRGLVCGTSCYMKQYGITRQEAVEAYREMIEVAWKDMNEGCLKPMPVSNKVALRPLNFARLVLVAYMKDDGFTRPELSMKDVIAKVLIHPIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UL59</accession>
    <name>A0A0D2UL59_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G129000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56640">
        <property type="protein sequence ID" value="KJB56640"/>
        <property type="gene ID" value="B456_009G129000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMTDNAP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000179">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000059">
        <property type="entry name" value="ABC transporter G family member 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
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        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48040:SF20">
        <property type="entry name" value="PLEIOTROPIC DRUG RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48040">
        <property type="entry name" value="PLEIOTROPIC DRUG RESISTANCE PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="573"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="650"/>
            <end position="669"/>
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    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="675"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1216"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1294"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1329"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1359"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1390"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1438"/>
            <end position="1461"/>
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            <begin position="163"/>
            <end position="436"/>
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    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="869"/>
            <end position="1122"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="817"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB56640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1469" mass="165483" checksum="4B7329D76EC60375" modified="2015-04-29" version="1">MVMEGGDIIKASNSLRGSLRAGSLRAGSSSIWRNSAVDVFSRSSRDEDDEEALKWAALEKLPTVARLRKGILTGSQGGANEVDVDNLGWQEKRTLLERLVKVAEEDNERFLLKLKNRIDRVGIDLPTIEVRYENLNIEAEAFVGTSALPSVLNFITSIFENFLIDMGVLSSRKKKLTILKDVSGIVKPGRMTLLLGPPSSGKTTLLLALAGKLDPALQFSGSVTYNGHTMKEFVPQRTAAYISQYDLHIGEMTVRETLAFSARCQGVGTRYDMLSELSRREKQANIKPDPDIDVFMKAVATEGQEANVITDYIMKILGLDMCADTLVGNEMLRGISGGQKKRVTTGEMLVGPARALFMDEISTGLDSSTTFQIVNCLRQTVHILNGTALISLLQPAPETYNLFDDIILLSDSVIVYQGPREHVVSFFESMGFKCPERKAVADFLQEVTSRKDQMQYWARKDQPYRFITANEFAEEFQSFHVGMKLGEELGTPFDKTKSHPAALATKKYGLGKWELLKACFARELLLMKRNSFVYIFKIIQLTIVSCITMTLFLRTEMDRDSVQGGSNYMGALFFGMIFLMFCGMPELSMTITLLPVFYKQRDLLFFPPWVYALPSWILKIPMTLIEVSVWVFITYYTVGFDPNIQRFVRQFLLLVLISQTAASLFRFIASATRNIIVANTFGTFSLLVLFALSGFVLAREDIRGWWIWGYWISPLMYGQNALMVNEFLGHQWSPVPPGSNESIGLQVLKSRSFFHESYWYWLGVGALVIFVVLYNVFFTLALTYLKPFEKNRAVISEKPQSNDQANGVGGSIQLADHENSSSHVNRSELQDDIQRNTSSSKSFSLSDATLRINGKKKKGMVLPFEPHSLTFEDIYYSVDMPQEMKEQSITEDDRLVLLKGISGAFRPGVLTALMGVSGAGKTTLMDVLAGRKTGGYIEGNITVSGFPKKQETFARISGYCEQNDIHSPHVTVYESLVYSAWLRLANDIDAETRKMFIEEVMELVELDSLRHAIVGLPGVNGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELFLMKRGGQEIYVGPLGHHSKYLIKYFEGIQGVSKIKDGYNPATWMLEVTASAQELSLGVDFADIYKNSHLYRRNKALIEDLSKPAPGAKELYFATQYSQPFLSQCAACLWKQHWSYWRNPPYTAVRFLFTTAIALMFGTLFWDLGSKTKKLQDLSNVMGSMYAAVLFIGIQNSSSVQPVVSVERTVFYRERAAGMYSAMPYAIGQVLIEIPYIFVQASGYGIIVYSMVGFEWTAAKFFWYIFFMLFTLLYFTFYGMMAVAVTPNSHIAAIVSSAFYGLWNLFSGFIIPRSSMPVWWRWYYWICPVSWTLYGLLVSQFGDINELLEDGNNETVKQYLRNYYGFRHDYLGLVAAVIISFAVLFGTIFAVAIKMFNFQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM00</accession>
    <name>A0A0D2UM00_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_011G001900</name>
        <name evidence="15" type="ORF">Gorai_005041</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0598798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM00"/>
    <dbReference type="Gramene" id="KJB68991">
        <property type="protein sequence ID" value="KJB68991"/>
        <property type="gene ID" value="B456_011G001900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUJJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MANWIGV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000041">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF19">
        <property type="entry name" value="POLLEN RECEPTOR-LIKE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220184" description="Protein kinase domain-containing protein" evidence="12">
        <location>
            <begin position="27"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="327"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="597"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB68991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0598798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="639" mass="71308" checksum="B698D11FF9BFA3DF" modified="2015-04-29" version="1">MKMTILGTRIAILSLWSLVIVSLGDMGDTENLLKFKDSLANPSSLRNWNASTSPCKGSMANWIGVICVKNKIWGLQLENMNLRGLVNIQILDKLPTLRIISLMNNDFEGIMVNIRKLEALKALYLSNNRFHGEIPDDAFEGMRSLKKVFLANNVFSGKIPSSLTVLPNLVILRLEGNQFEGHIPDFKQELKVVCLANNKLEGPIPKSLSRMSATMFSGNKNLCGKPLQACTSSPPRPPPSSKEKTLSSVKIALIVLSTALLLLIIAILILFLTWRTQTESQKANVVNEAKRVSKSGSMVKAAGFEHGSTLMILRDGAQRFDLQDLLKASAEVLGSGNLGASYKVEMEKDDGVVVAVVKRYKQMNNAGKDEFYEHMTRLGKLNHKNLLPLMAYHYMKEEKLLVSQYTDNGSLATHLHGNPCEDKPGLSWQTRLKIIKGIARGLSHLYKELPTLILPHGNLKSSNVLLDHTFKPLMCDYGLTPLINQEQVHMFMAAYKSPEYALKGRVSKKTDVWCLGILILELLTGKLPENYVQPKYNSKANLGSWVKEKMSSESVFDDGLLGTKDDKRDEVMSVLKIGLKCCEEDLNKRPELKQVVQEIEQLGDDEDEDEDDDDDDDDDEFCSTICEVNASICSEKCER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UVR5</accession>
    <name>A0A0D2UVR5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="22">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_011G191800</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(3S)-3-hydroxybutanoyl-CoA = (3R)-3-hydroxybutanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:21760"/>
            <dbReference type="ChEBI" id="CHEBI:57315"/>
            <dbReference type="ChEBI" id="CHEBI:57316"/>
            <dbReference type="EC" id="5.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45228"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:45900"/>
            <dbReference type="ChEBI" id="CHEBI:85097"/>
            <dbReference type="ChEBI" id="CHEBI:85489"/>
            <dbReference type="EC" id="5.3.3.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UVR5"/>
    <dbReference type="STRING" id="29730.A0A0D2UVR5"/>
    <dbReference type="Gramene" id="KJB72706">
        <property type="protein sequence ID" value="KJB72706"/>
        <property type="gene ID" value="B456_011G191800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB72708">
        <property type="protein sequence ID" value="KJB72708"/>
        <property type="gene ID" value="B456_011G191800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777302"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003857">
        <property type="term" value="F:(3S)-3-hydroxyacyl-CoA dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008692">
        <property type="term" value="F:3-hydroxybutyryl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004300">
        <property type="term" value="F:enoyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.50:FF:000004">
        <property type="entry name" value="Peroxisomal fatty acid beta-oxidation multifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000025">
        <property type="entry name" value="Peroxisomal fatty acid beta-oxidation multifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006180">
        <property type="entry name" value="3-OHacyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23309:SF9">
        <property type="entry name" value="PEROXISOMAL FATTY ACID BETA-OXIDATION MULTIFUNCTIONAL PROTEIN MFP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00067">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="21">
        <location>
            <begin position="314"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="20">
        <location>
            <begin position="495"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB72706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="725" mass="79487" checksum="41F57992CEE36535" modified="2015-04-29" version="1">MGSKNNGRTTLEVGADGVAIITIINPPVNSLSPDVLYSLKESYDEALQRDDVKAIVVTGTNGKFSGGFDITSFDGMQSGKVEQPKLGFVSVEIVSDTLEAAKKPSVAAIDGLALGGGLEVAMACHARISTPTAQLGLPELQLGVIPGFGGTQRLPRLVGLTKSLEMMLTSKPVKGEEAVGLGLVDAVVSSHELIETARRWALDVLARRKPWVATLYKTEKLEPLGEAREIFNFARAQARKRAPNLKHPLVCIDVIEEGIVAGPRAGLWKEAEAFQVLLKSDTCKSLVHIFFAMRGTSKVPGITDRGLMPRQVRKVAVLGGGLMGSGIATALILSNYTVILKEVNEKFLEAGIDRVKANLQSRVKKGKMSQEKFEKTISLLSGVLDYERFRDVDMVIEAVIENVSLKQQIFADLEKFCSPHCILASNTSTIDLNLIGERTKSQDRIVGAHFFSPAHVMPLLEIVRTRQTSPQIIVDMLDVGKKIKKTPIVVGNCTGFAVNRMFFPYTQLGLFLVERGTDVYRIDRVITKFGMPMGPFRLADLVGFGVAIASGMQFIENFPERTYKSMLVPLMQEDKRTGEGTRKGFYSYDNERKPSPDPELYKYIEKSRSISGVAVDPKFVKLSDKDIVEMIFFPVVNETCRVLAEGIAVKAADLDIASVMGMGFPPYRGGIMFWADSLGSNYIYCRLEEWTKMYGEFFKPCAFLAELAAKGAPLSAAVEQAKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UWW3</accession>
    <name>A0A0D2UWW3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G230000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UWW3"/>
    <dbReference type="STRING" id="29730.A0A0D2UWW3"/>
    <dbReference type="Gramene" id="KJB73373">
        <property type="protein sequence ID" value="KJB73373"/>
        <property type="gene ID" value="B456_011G230000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73374">
        <property type="protein sequence ID" value="KJB73374"/>
        <property type="gene ID" value="B456_011G230000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776863"/>
    <dbReference type="eggNOG" id="KOG2953">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="79"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="151"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB73374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51282" checksum="DE04EDF3CD92814D" modified="2015-04-29" version="1">MEGSVVEDLGAPDSWEVADLDATMSRLMLSSNKESKPEFPDATSSASASGSPDEKVVSEDAINEVDQFLREAIQNPRERLSILRMEQDVEKFIRDPNQQQFEFQQLPTSYLRLAAHRIAQHYSLQSMVLLDNNLPDGSGSRIIVCKTSECRLPRIRLADIPVNLPSEDPGVVKVAIKQRPQKRSQLVSNSNSNSMKSNSSKSVEERKEEYNRARARIFNSSSSSSGSGGKPPSEPRLQDVNYYGSSRMPNMEEKSVSVVADVNSGSGLIEYSSSSSRSARSRTEKEPIGRSKPHNRVAIFRDRETDRKDPDYDRNYDRYMQRFDPGFGFNSGPYTMQPMYTPAINYNTEFPQLGSTHRPQIATEHQPRPLPQHIPGPWVAPPTATGISYGHPETMMPPFNPNHVGARSTSAIYLHSSQYPLQRPGMPFIHPHEHVHQPFSQPHQHQPDASFGLARPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UY92</accession>
    <name>A0A0D2UY92_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G263400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ZIP transporter (TC 2.A.5) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UY92"/>
    <dbReference type="STRING" id="29730.A0A0D2UY92"/>
    <dbReference type="Gramene" id="KJB73956">
        <property type="protein sequence ID" value="KJB73956"/>
        <property type="gene ID" value="B456_011G263400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775178"/>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYTGCHS"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004698">
        <property type="entry name" value="Zn/Fe_permease_fun/pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00820">
        <property type="entry name" value="zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF41">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265785" evidence="9">
        <location>
            <begin position="30"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB73956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="355" mass="38316" checksum="4EBB45AC3676CCE6" modified="2015-04-29" version="1">MKSVLKSLANSTFLVLFIIFSSSTPLVLAQCEAETKTNGCHNYRESMKLKIIAIVAILLSSMIGVCLPLFSGQVPSLKPDRDLFTIVKAFSSGVILATGYMHVLPDSFNDLMSGCLPENPWRKFPFTTFVAMLSAVLTLMVDSFAMSVYKKRCGKALMADANNGGGLENTNVVQVDNFEHGHSHSLEMNDDVSSQLLRHRVIAQVLELGIVVHSVVIGLAMGASGNQCTIRSLIAALCFHQMFEGMGLGGCILQAEYEIKMKAIMVFFFSATTPLGIVLGIGLSKVYSETSPTSLMVVGLLNACSAGLLNYMALVDLLAADFLGPKLQTNMKLQAWSYVAVLLGAGFMSLMAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYN9</accession>
    <name>A0A0D2UYN9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G273700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYN9"/>
    <dbReference type="STRING" id="29730.A0A0D2UYN9"/>
    <dbReference type="Gramene" id="KJB74114">
        <property type="protein sequence ID" value="KJB74114"/>
        <property type="gene ID" value="B456_011G273700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="CDD" id="cd22157">
        <property type="entry name" value="F-box_AtFBW1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="8"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB74114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="236" mass="27614" checksum="6703184D2897B1E7" modified="2015-04-29" version="1">MQMPRFEVPEALVMEILSKLPVKSLTRFNCVCKYWCSFFRTPHFISKHYHNNVKNNNLNLVLQRHDHGTANMPYFSQSSNQLPYVYGARHGLFCLYDCLTDKAAIWNPSTREFKILSPSSVQAILMPFSVSPIPKFFESYREHYIQELKELTDLLIYGLRMKEYGINNSALNLFRLVLFDPSSQEFKVVGIKTYMEHHQHYISVFAFVENRVPINGIQEHKDHIICQLVGDAPNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V0G5</accession>
    <name>A0A0D2V0G5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G408300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA glycosylase family. DEMETER subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62197">
        <property type="protein sequence ID" value="KJB62197"/>
        <property type="gene ID" value="B456_009G408300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62198">
        <property type="protein sequence ID" value="KJB62198"/>
        <property type="gene ID" value="B456_009G408300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62199">
        <property type="protein sequence ID" value="KJB62199"/>
        <property type="gene ID" value="B456_009G408300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62200">
        <property type="protein sequence ID" value="KJB62200"/>
        <property type="gene ID" value="B456_009G408300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62201">
        <property type="protein sequence ID" value="KJB62201"/>
        <property type="gene ID" value="B456_009G408300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767395"/>
    <dbReference type="eggNOG" id="ENOG502QQKH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5607at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035514">
        <property type="term" value="F:DNA demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019104">
        <property type="term" value="F:DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141166">
        <property type="term" value="P:chromosomal 5-methylcytosine DNA demethylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1670.10:FF:000004">
        <property type="entry name" value="DNA glycosylase/AP lyase ROS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044811">
        <property type="entry name" value="DME/ROS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028924">
        <property type="entry name" value="Perm-CXXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028925">
        <property type="entry name" value="RRM_DME"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46213:SF13">
        <property type="entry name" value="DEMETER-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46213">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR DEMETER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15629">
        <property type="entry name" value="Perm-CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15628">
        <property type="entry name" value="RRM_DME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="11">
        <location>
            <begin position="1354"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="441"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="959"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1278"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1111"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1282"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB62200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1893" mass="211237" checksum="2BA2F07F8E55A4E5" modified="2015-04-29" version="1">MSKQGQERPVIHIELQENQIFGANCIESERCSFGFAQESQTEGVVACSDSGSCTEVNGSFNNLMAASVWSESFSCGQNPAELGNVSSVDLSAIATAVSAASTSAAPVGINNHSGCGPSGLFPVHVNLSTQRNIRIAGNCTPRKNQNVIPPQNPYDYDFNLPAGPSEAFSQTSISDFAPITPDKARTAEMKEVPEIGKLYIVNITEKQDEQANELVPARLDVNVVQCSKELQMPVLKSSLTATPSKENQNSDNGGSHLAELEITTPQQKQRKRKHRPKVITEGKPRRPRKPATPKPDGSQETPTGKRKYVRKSTVKNDTSILLGVANAEKSTGKRKYVRRKGLNKDSTIPTQEGGKGATHPETLEHNKKPCRRALDFDTVGQEREESSACKPACNLNSSPGTENLGKEGSQSKSMVQLCGIIEVDAEKTQTGIAFELKQSVKEKPKDDLSLPEDQAPGTPVPTKNNPSHRRQNTHPQKLSNRRGKDKATGHDGLKRNERTTLDSDAQLPARSLIDSKCRTSSLLEGGQANKSAATQQEDTRIVNSYGSHYNNFCAYQMILGMQFPHIHRRKRTGKGQNSATSSASSSITAARSLVPAEACLVDKMEVNPHQLISSGVSTEHEAGRKFSLNKMQTFNYIMASNQTESSKKKRTRETTGIQDLASLNGIAQRKRHPEYRSSQPPVDYDMREVGNTDRPQTSMEALVTEMQAKLAKTKQTKKRNCLVSSACSSTNEAQMHKKLLRASPEEIWKQFFSVDALLEQFNQLDINREGSAIACQEQNALVPYNMIYQEHNALVVYRDGTIVPFVPTRKRRPRPKVDLDEETNRVWKLLLENINSEGIDGTDEEKAKWWEEERRVFSGRADSFIARMHLVQGDRRFSPWKGSVLDSVIGVFLTQNVSDHLSSSAFMSLAARFPIKSKSKDKLYHQEGTSLVNGEEFYVLEPEESIKWDAKTAIQPVGDQSSMTVDGYQDSEEKEVANSEELSGSSTATVSSINEPKCNLLNSSGSGLSKYCDSTANRLNMETIRGKTECFKGDEETNDVLSSQNSVVSSENSGDFSLVQTAERTGSCSEGNSEGADHTKRPIFNILNGSTSFVQLLQMVGSARLHEVQSHQNMSPNENSNVRTSQFQNHTRENCDNSDGPKSFTREDLMPSANYHPYLTLNSEVREIGHFETLKEETRVSEASKTIDESMIKRLSPLTQESASRTMDQNDKTRSVQVAQQSTFENFQSSTNTIPVEMTVSHCPKGLLQDTINLVESPAEAQNKEMLRHVSMSKHSEETLDITESSTAFDNQRTPQQKMQESNLYTHDSSSNKELNSMVGELKSEGRKVKKEKKDDFDWDSLRKQTEVNGRKREKTERTMDSLDWEAVRCAEVHEIAETIKERGMNNVLAQRIKDFLNRLVRDHGSIDLEWLRDVPPDKAKEYLLSIRGLGLKSVECVRLLTLHHLAFPVDTNVGRIAVRLGWVPLQPLPESLQLHLLELYPILESIQKYLWPRLCKLDQRTLYELHYQMITFGKVFCTKGKPNCNACPMRGECRHFASAFASARLALPGPEEKSIVSATENGTSDRNPAVIIDQLALPLPQSNELLDRNYQSEANQQLQAASTVNKCDPIIEEPASPEPECTQVAENDIEDMFSEDPDEIPTIKLNMEEFTQTLQNYMQNNIELQEGDMSKALVALTAEAASIPTPRLKNVNRLRTEHQVYELPDSHPLLNELDKREPDDPCKYLLAIWTPGETANSIQQPERRCNSQEHGKLCDDETCFSCNSIQEAESQIVRGTLLIPCRTAMRGSFPLNGTYFQVNEVFADHDSSLNPIAVPREWLWNLPRRMVYFGTSIPSIFKGLTTEGIQHCFWRGYVCVRGFDQKSRAPRPLMARLHFPASRLAKAKGKGAGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4V2</accession>
    <name>A0A0D2V4V2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G133100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V4V2"/>
    <dbReference type="Gramene" id="KJB77346">
        <property type="protein sequence ID" value="KJB77346"/>
        <property type="gene ID" value="B456_012G133100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S4EN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PPNFFPN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040277">
        <property type="entry name" value="Os04g0629400-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36036">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36036:SF1">
        <property type="entry name" value="PROLINE-RICH FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB77346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="157" mass="16108" checksum="30A698A57C68A477" modified="2015-04-29" version="1">MCYVGKATKIFIFIVTALVVLGLVLGFGLLRHHKSHSHKCSGGDSCPSPNFFPNPISTPNSPPFSSSSSSYNPPPLAIGSNQPTSPNSPPTSIPTANPPPPPSTPPAVQDPTPTPPPPDANPNPPPQSTPPPPPAVLPVPPYNQPTPVLVAPGPVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V7T9</accession>
    <name>A0A0D2V7T9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">20 kDa chaperonin, chloroplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Chaperonin 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein Cpn21</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G091000</name>
        <name evidence="8" type="ORF">Gorai_007466</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V7T9"/>
    <dbReference type="STRING" id="29730.A0A0D2V7T9"/>
    <dbReference type="Gramene" id="KJB65345">
        <property type="protein sequence ID" value="KJB65345"/>
        <property type="gene ID" value="B456_010G091000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB65347">
        <property type="protein sequence ID" value="KJB65347"/>
        <property type="gene ID" value="B456_010G091000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773814"/>
    <dbReference type="eggNOG" id="KOG1641">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="PRK00364.2-2"/>
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    </dbReference>
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        <property type="entry name" value="20 KDA CHAPERONIN, CHLOROPLASTIC"/>
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    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
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    <dbReference type="PIRSF" id="PIRSF038157">
        <property type="entry name" value="Chaperonin_21_chloroplast"/>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
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    <dbReference type="SMART" id="SM00883">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0143">Chaperone</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00031971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00073031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00079398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB65345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0597666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="256" mass="26937" checksum="1E01583FEC112636" modified="2015-04-29" version="1">MATSQLTASSVTASARNLASLQGLRLSTVKFSSFGTLKPGALTSRSFKRLVVKAATVVAPKYTSVKPLGDRVLVKIKETEEKTEGGILLPTTAQSKPQGGEVVAVGEGKTIGNTKLESSVKTGAQVIYSKYAGTEVEFNGANHLLLKEDDIVGLLETDDIKDLKPLNDRVFIKVSEAEEKTAGGLLLTEASKEKPSIGTVIAAGPGTLDEEGNLKPLSVSPGNTVLYSKYAGNDFKGNDGSNYIALRASDVMAVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V8U1</accession>
    <name>A0A0D2V8U1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_010G114100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="SMR" id="A0A0D2V8U1"/>
    <dbReference type="Gramene" id="KJB65810">
        <property type="protein sequence ID" value="KJB65810"/>
        <property type="gene ID" value="B456_010G114100"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
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        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
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        <location>
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            <end position="219"/>
        </location>
    </feature>
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            <begin position="231"/>
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        </location>
    </feature>
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            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="306"/>
        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
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        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB65810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="349" mass="38652" checksum="3499E9495A9E78FF" modified="2015-04-29" version="1">MGKGGSLSDGVIKKILLSYTYVAIWIFLSFTVIVYNKYILDKKMYNWPFPISLTMIHMSFCASLAFLLIKVFKVVEPVSMSRDLYLSSVVPIGALYSLSLWLSNSAYIYLSVSFIQMLKALMPVAVYSIGVLFKKEGYKNDTMVNMLSISFGVAIAAYGEAKFDTWGVILQLGAVAFEATRLVMIQILLTSKGITLNPITSLYYVAPCCFVFLLVPWVFVEYPVLKETSSFHFDFVVFGTNSICAFALNLAVFLLVGKTSALTMNVAGVVKDWLLIAFSWSVIKDTVTPINLFGYGLAFLGVAYYNHSKLQALKAKEAQKKTAQADEEGGRLLEEREGEGSGKSSESQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSB7</accession>
    <name>A0A0D2VSB7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
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        </recommendedName>
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    <gene>
        <name evidence="10" type="ORF">B456_011G269100</name>
        <name evidence="11" type="ORF">Gorai_006706</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0600521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSB7"/>
    <dbReference type="SMR" id="A0A0D2VSB7"/>
    <dbReference type="STRING" id="29730.A0A0D2VSB7"/>
    <dbReference type="Gramene" id="KJB74050">
        <property type="protein sequence ID" value="KJB74050"/>
        <property type="gene ID" value="B456_011G269100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777133"/>
    <dbReference type="eggNOG" id="KOG1322">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="8">
        <location>
            <begin position="2"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="9">
        <location>
            <begin position="251"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB74050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0600521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="361" mass="39574" checksum="0B1783E4EE500208" modified="2015-04-29" version="1">MKALILVGGFGTRLRPLTLSVPKPLVEFANKPMILHQIEALKAVGVTEVVLAINYQPEVMLNFLKEFETKLGITITCSQETEPLGTAGPLALARDKLVDESGEPFFVLNSDVISEYPFKEMIEFHKAHGGEASIMVTKVDEPSKYGVVVMEESTGQVDKFVEKPKLFVGNKINAGIYLLNPSVLDRIELRPTSIEKEVFPKIAAEKKLYAMVLPGFWMDIGQPRDYITGLRLYLDSLRKKASPKLASGPNVVGNVLVHETAKIGEGCLIGPDVAIGPGCVVESGVRLSRCTVMRGVRIKKHACISSSIIGWHSTIGQWARVENMTILGEDVHVCDEIYSNGGVVLPHKEIKSSILKPEIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VXT7</accession>
    <name>A0A0D2VXT7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G105500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VXT7"/>
    <dbReference type="STRING" id="29730.A0A0D2VXT7"/>
    <dbReference type="Gramene" id="KJB76755">
        <property type="protein sequence ID" value="KJB76755"/>
        <property type="gene ID" value="B456_012G105500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779261"/>
    <dbReference type="eggNOG" id="KOG0656">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DDHMEMS"/>
    <dbReference type="OrthoDB" id="62at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20544">
        <property type="entry name" value="CYCLIN_AtCycD-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000060">
        <property type="entry name" value="D6-type cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="94"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB76755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="358" mass="41470" checksum="6B12FC5B24187AAB" modified="2015-04-29" version="1">MSSFSKSESRIAMENLLCDEVWLSSPGTPDLSHESEHYIWKGYGYADLFYTTKEDSEQALVICLKKEFSYMPEAGYLDYLQSKNLVFARFRAVQWLIKTCTRLNLSIGTVFNAVNYLDRFLSMSQCHGWKHWMMELLSVACLSIAAKFNETSLPSLDELQMEDLEHCFQPSTIQQMELMVLQALKWRLGSTTSYSYIELITSNYICDINYNLHKELINQVNRTLVKAILDFELVPYPPSVVAVSALWCSLEELVPSSYNAHLTKILKLINQDHEDDVMECRRIMKAWVVHPFYNMKVSEQYSHYYPPSPVTVLLTDRIDMINDCQVDLSVFKMPLAGSNAFKLDRESSGNRKRKKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W9J1</accession>
    <name>A0A0D2W9J1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G258100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB83680.1"/>
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    </dbReference>
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        <property type="gene ID" value="B456_013G258100"/>
    </dbReference>
    <dbReference type="OMA" id="CCSSGIG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB83680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="16001" checksum="71D5D6A119DCFB3F" modified="2015-04-29" version="1">MNGFLQKRENDRSPLNLFECWGFQFNENERHCFFTGKFLLKPLPIYIAEAMDCQCCSSGIGECHSGRMTKENKMLQLHMKTPTSSTSSSLACTCLSLSGNPETIGNANNGLIFMMKTTLLSPTTLIALHEKSLEWKVYLVNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LT35</accession>
    <name>A0A0D2LT35_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">Oxidative stress 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G009600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJB07232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2LT35"/>
    <dbReference type="Gramene" id="KJB07232">
        <property type="protein sequence ID" value="KJB07232"/>
        <property type="gene ID" value="B456_001G009600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HELGNNG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF99">
        <property type="entry name" value="COLD INDUCED PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB07232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="14985" checksum="2FD8B1FCF03D93D9" modified="2015-04-29" version="1">MKKMESDESSFENSINASIASSSDLVDDATSSASSSNGPLYELSEMMAQLPIKRGLSKHYHGKSQSFTSLANVKSIEDLPKKVVRVRAKMMKSCKSYGWGLDGHHHHNKVYYSPKATISKKGSSSTRVCFMSSSLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G0137001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_001G0137001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1689">
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    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
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    <dbReference type="PANTHER" id="PTHR13047">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
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    </dbReference>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB07287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="11128" checksum="57E4C047CCB14C39" modified="2015-04-29" version="1" fragment="single">MGDDDEHNSSSTDEGRKEMDIYPLSCYYFGSKEAIVFKDETVSDRITRMKSNYAAYGLRTSVEAVLLVELFKHPHLLLLQLNNSIFKLPGGRLRPGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M3V5</accession>
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            <fullName evidence="4 18">Peroxidase</fullName>
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        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="20 21">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 18">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M3V5"/>
    <dbReference type="STRING" id="29730.A0A0D2M3V5"/>
    <dbReference type="Gramene" id="KJB11687">
        <property type="protein sequence ID" value="KJB11687"/>
        <property type="gene ID" value="B456_001G271900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QT4B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSHCERF"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000008">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF45">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 18" id="KW-0349">Heme</keyword>
    <keyword evidence="12 18" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="8 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 18" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112602" description="Peroxidase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="23"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="33"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="66"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="119"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB11687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="324" mass="35426" checksum="FFCDB39A84B150B9" modified="2015-04-29" version="1">MAVRTWLMILFLVFMMMQKGKGQLSETFYRTSCPKVESIVRKVVTEKINQTFVTIPATLRLFFHDCFVEGCDASVLISSPNGDAEKDAPDNLSLAGDGFDTVIKAKTEVEKSCPRVVSCADILTIATRDIIELAGGPSFKVELGRRDGLISKASRVTGNLPDPNFNLTQLNTMFAKNNLTQTDMIALSGAHTVGFSHCSRFANRLYSFSPSSPVDPDLDPTYAQQLMQACPQNVDPRIAINMDPATPQTFDNMYFQNLVTKKGLFTSDEVLFTNKASQATVIDFANNPGDFSGAFVTAIRKLGRVGVKTGNAGQIRVDCTAFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MNK2</accession>
    <name>A0A0D2MNK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12 15">Homoserine dehydrogenase</fullName>
            <shortName evidence="12">HDH</shortName>
            <ecNumber evidence="5 12 15">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_003G140000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12 16">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 12 15"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MNK2"/>
    <dbReference type="SMR" id="A0A0D2MNK2"/>
    <dbReference type="STRING" id="29730.A0A0D2MNK2"/>
    <dbReference type="Gramene" id="KJB20242">
        <property type="protein sequence ID" value="KJB20242"/>
        <property type="gene ID" value="B456_003G140000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788923"/>
    <dbReference type="eggNOG" id="KOG0455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYTRCYS"/>
    <dbReference type="OrthoDB" id="67851at2759"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N527"/>
    <dbReference type="Gramene" id="KJB27252">
        <property type="protein sequence ID" value="KJB27252"/>
        <property type="gene ID" value="B456_004G286600"/>
    </dbReference>
    <dbReference type="OMA" id="NTRDNNE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36801">
        <property type="entry name" value="OS06G0150200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36801:SF3">
        <property type="entry name" value="OS06G0150300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB27252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22002" checksum="47C4A9D0C376751A" modified="2015-04-29" version="1">MGRIVPLDGDVVIHPALPFSLVVAATAATIAIITGLCGFFRKPPPELQEPTSADTTSPTNEEQEPNTTADGGETEEGGNELLPPPPCMAALTFKNPENAGNLMKKSASTRSKLSSTFSVKKHLRSISVREIIEKGKHVQQKHHQEDSLWTKKIILGEKCKVSYGVEDDDEDQNGGNKGEVDTIPAAGNEDAIVDKEKEITSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N745</accession>
    <name>A0A0D2N745_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Trichome birefringence-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G083200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N745"/>
    <dbReference type="Gramene" id="KJB08473">
        <property type="protein sequence ID" value="KJB08473"/>
        <property type="gene ID" value="B456_001G083200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788774"/>
    <dbReference type="eggNOG" id="ENOG502QSS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWHMLHI"/>
    <dbReference type="OrthoDB" id="767975at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045492">
        <property type="term" value="P:xylan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533">
        <property type="entry name" value="N-ACETYLNEURAMINATE 9-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13533:SF31">
        <property type="entry name" value="PROTEIN ALTERED XYLOGLUCAN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265277" description="Trichome birefringence-like N-terminal domain-containing protein" evidence="6">
        <location>
            <begin position="17"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB08473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42073" checksum="A218745387D07A31" modified="2015-04-29" version="1">MLMMMLGAVQLGAAAACVVVLVPMGMAGWHLSRNKMLFFSGALFISLAICVHLTPYFPSVPDFVTSVSSAVVFDHRSSCINLVNEISWEVKPNASFHHFNNTQNSSSIADFYDKRWDWSDSYKLKACEFTKLSKSDASDLLNGSWVVIAGDSQARLFTLSLLNLILGPQSQRMDSVRADLFKRHSDYSVLVNETGMKLDFIWAPYVMNLTNLVMNFKTQKNCPDVMIMGAGLWHMLHFTNASDYDLHLHILKTQVVSLLPFSTELAMNEPVTGSVPIKSSHLFWLGMPVLINGMLNTEEKRAKMNDAMWHAYDKALGDSKLLRQTGGPLFLLDFQSLTWNCGPHCTSDGMHYDGAIYEAAVQIMLNTLLIESHQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8M1</accession>
    <name>A0A0D2N8M1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G121700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8M1"/>
    <dbReference type="STRING" id="29730.A0A0D2N8M1"/>
    <dbReference type="Gramene" id="KJB09053">
        <property type="protein sequence ID" value="KJB09053"/>
        <property type="gene ID" value="B456_001G121700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792623"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTFHGCS"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000523">
        <property type="entry name" value="Zinc finger protein WIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043584">
        <property type="entry name" value="WIP1/2/3/4/5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059161">
        <property type="entry name" value="Znf-C2H2_STOP1/2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45878">
        <property type="entry name" value="ZINC FINGER PROTEIN WIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45878:SF24">
        <property type="entry name" value="ZINC FINGER PROTEIN WIP3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23115">
        <property type="entry name" value="zf-C2H2_STOP2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB09053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="359" mass="40677" checksum="8990151F09A50994" modified="2015-04-29" version="1">MNMGFRSYHVAEDKTLCFQAPTFIEWLKPSSSSSPSSSPSSSSSSSTISSSYVAQHVQLINPMNIMKRPLISFQQQQQQQQYHDFHKHQVGEETIQCLPLLSRFTENKPLKEEALQKVMSVGDVKEEKIEKVTVSLHIGLPNSSAAAAAEGDDNIPVVDHKILKEEEPMKKTFHGCSFNTMSRFWIPTPAQILVGPMQFACSICSKTFNRYNNMQMHMWGHGSEYRKGPDSLKGSQPAAMLRLPCYCCAQGCKNNINHPRAKPLKDFRTLQTHYKRKHGAKPFMCRKCGKTFAVKGDWRTHEKNCGKLWYCTCGSDFKHKRSLKDHIRSFGKGHSPHPSLEGFEDDKECITGSEDEFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NI14</accession>
    <name>A0A0D2NI14_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Beta-galactosidase</fullName>
            <ecNumber evidence="4 9">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G246600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
            <location evidence="2">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="4 9"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NI14"/>
    <dbReference type="STRING" id="29730.A0A0D2NI14"/>
    <dbReference type="Gramene" id="KJB32547">
        <property type="protein sequence ID" value="KJB32547"/>
        <property type="gene ID" value="B456_005G246600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795335"/>
    <dbReference type="eggNOG" id="KOG0496">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MLPTNVQ"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000037">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000061">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000142">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000021">
        <property type="entry name" value="Beta-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041392">
        <property type="entry name" value="GHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17834">
        <property type="entry name" value="GHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002259697" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="12">
        <location>
            <begin position="35"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase beta-sandwich" evidence="13">
        <location>
            <begin position="362"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="14">
        <location>
            <begin position="471"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="14">
        <location>
            <begin position="621"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="732" mass="81963" checksum="4062E9C927E1F2B3" modified="2015-04-29" version="1">MAANSISHCFSLSITILFLYLLLVHCNVTYDRKAIAIDGQKRILFSGSIHYPRSTPEMWEGLIQKAKNGGLDVIDTYVFWNLHEPSPGNYNFEGRYDLVQFIKLVKKAGLYVHLRIGPYICGEWNFGGFPVWLKYVPGISFRTDNEPFKKAMAKFTQKIVQMMKDENLFESQGGPIILSQIENEYEPESKLYGPAGKAYVKWAAKMAVGLNTGVPWVMCKEYDAPDPVINTCNGFYCDYFSPNKPYKPTLWTEAWTGWFSDFGGPNYQRPVEDLAFAVARFIQKGGSFVNYYMYHGGTNFGRTAGGPFITTSYDYDAPIDEYGLIRQPKYDHLKELHKAIKLCEKALLNSDPNIVILGSYEKAHVFSSESGGCAAFLSNYNLRSNAKVTFNNIHYNLPRWSISILPDCRNVVFNTAKVGTEASRVQMVPTNVKIESWETFNEDVHSVDDESSMTVKGLLEQLNITRDTSDYLWYTTSVRISSSESFPRKGTPLTLSIQTAGHGIHVFINGQLSGSAFGTQQKRKFSFTKNINLHPGENKISILSIAVGLPNIGPHFETRNIGVQGPVVLHGLDEGKKDLTWQKWSYKVGLKGEADNLGSPNSIPSNDWTRGSLATLKQRPLTWYKAFFNAPGGDDPLALDMSGMGKGQVWINGESIGRYWTISVNGNCSGCSYVGAFRQTKCHFGCGGPTQQWYHVPRSWLKPTRNSLVVFEEIGGDASKISIVKRLTATDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKX6</accession>
    <name>A0A0D2NKX6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_006G029000</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKX6"/>
    <dbReference type="Gramene" id="KJB33752">
        <property type="protein sequence ID" value="KJB33752"/>
        <property type="gene ID" value="B456_006G029000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HLKMAWV"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000231">
        <property type="entry name" value="RING-H2 finger protein ATL46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF13-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45768:SF78">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="163"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="342"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="342"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="370" mass="41712" checksum="E0346B2C884A173D" modified="2015-04-29" version="1">MICGMLESKENSWVLEHDHLKMSWFHHYHQIKQKDGYFQYPSPLLLPPYAPPGFHKDSSPSSPSSSSGSRISPALLFIIVILAVLFFISGLLHLLVRFLTKHPPSSTSSQSNRYPEISTSDALQRQLQQLFHLHDSGLDQAFIDALPVFHYKEIVGLKEPFDCAVCLCEFSEKDKLRLLPMCSHAFHINCIDTWLLSNSTCPLCRGTLFTPGFSMENPMFEFDEIREDEGLHGQKTMEIEEIVVDKGVLPVRLGKFKRLDGQPRESLGETSSSNLDARRCFSMGSYQYVLGASDLRVTLSYDKRHGCDVKPSVEGKKISSASKGESFSVSKIWLWSKKGKLSTSSSDEQMGMPSSLNTELPPWLVKTQEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P2P7</accession>
    <name>A0A0D2P2P7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cornichon family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G167000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P2P7"/>
    <dbReference type="SMR" id="A0A0D2P2P7"/>
    <dbReference type="STRING" id="29730.A0A0D2P2P7"/>
    <dbReference type="Gramene" id="KJB20822">
        <property type="protein sequence ID" value="KJB20822"/>
        <property type="gene ID" value="B456_003G167000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB20823">
        <property type="protein sequence ID" value="KJB20823"/>
        <property type="gene ID" value="B456_003G167000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789206"/>
    <dbReference type="eggNOG" id="KOG2729">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNHYLID"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB20823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="16488" checksum="684C788002A4245F" modified="2015-04-29" version="1">MLDIFIWLISFFIIIAIIVLLIYQLTCLADLEFDYINPYDSSSRINKVVLPEFFVQGFLCLFYLVTGHWVMSLLCTPYLYYNVKVYMLKQHLVDVTEIFNSLNREKNRRYYKLAYLVILLFISLFWIIFSALEYEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P401</accession>
    <name>A0A0D2P401_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G273700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P401"/>
    <dbReference type="SMR" id="A0A0D2P401"/>
    <dbReference type="STRING" id="29730.A0A0D2P401"/>
    <dbReference type="Gramene" id="KJB21383">
        <property type="protein sequence ID" value="KJB21383"/>
        <property type="gene ID" value="B456_004G273700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21384">
        <property type="protein sequence ID" value="KJB21384"/>
        <property type="gene ID" value="B456_004G273700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21385">
        <property type="protein sequence ID" value="KJB21385"/>
        <property type="gene ID" value="B456_004G273700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792831"/>
    <dbReference type="eggNOG" id="KOG4495">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHCDPTE"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725">
        <property type="entry name" value="OS03G0364000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47725:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="11939" checksum="BBC6539FF0362838" modified="2015-04-29" version="1">MAMYIRVKRSKTTYFIQCDPTETTLDIKQKLHTLIDQPVNDQRLILMSNGDILEDSKTLADQKVENDAVVALTLRKDDNEFEDVNIVKPNDFYQSRDTDSGNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJX9</accession>
    <name>A0A0D2PJX9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COV1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G005800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJX9"/>
    <dbReference type="Gramene" id="KJB07174">
        <property type="protein sequence ID" value="KJB07174"/>
        <property type="gene ID" value="B456_001G005800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07176">
        <property type="protein sequence ID" value="KJB07176"/>
        <property type="gene ID" value="B456_001G005800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786327"/>
    <dbReference type="eggNOG" id="ENOG502QPUG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MAGHCND"/>
    <dbReference type="OrthoDB" id="534431at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010222">
        <property type="term" value="P:stem vascular tissue pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="COV-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876:SF15">
        <property type="entry name" value="COV-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB07174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29045" checksum="4C1D8510A5F72E08" modified="2015-04-29" version="1">MGDDKSAAMTASRDRELLIPVAESVHDDSSKASSSSSSASSHHAGRETFYKIVQSWASKKFMTGCVILFPIAITFYITWWFIHFVDGFFSPIYAQLGIDIFGLGFVTSITFIFLVGVFMSSWLGASVLGLGEWFIKRMPFVRHIYNASKQISSAISPDQNTQAFKEVAIIRHPRIGEYAFAFITSSVTLQSDAGEEELCCVFVPTNHLYLGDIFLINTKDVIRLNLSVREGIEIVISGGMSMPQILSTLDTQLERSRPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PMI3</accession>
    <name>A0A0D2PMI3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450 71A9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G063600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PMI3"/>
    <dbReference type="STRING" id="29730.A0A0D2PMI3"/>
    <dbReference type="Gramene" id="KJB08074">
        <property type="protein sequence ID" value="KJB08074"/>
        <property type="gene ID" value="B456_001G063600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786693"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHGLGNN"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF19">
        <property type="entry name" value="CYTOCHROME P450 71A9-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB08074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59728" checksum="6B4DAF93ABAAF680" modified="2015-04-29" version="1">MSILSPSFKFHSFSCQTPKPIVKKSYSMDFQFILTLSFIAFTLMVFKYKARTRRLPPGPWKLPIIGNLHQLGDSSHKSIQRLSQQYGPMMFLQLGAVPTLVISSADAAMAIFKGPGGGYDLAFSGRPTNLYVAKKLSYEYNGITFAPYGELWREMRKIAVAELLSSKRVQSFRTIREEEVAAMLNHIDIASSSSAPVNLKKLSLLLANHVVCRVTFGKKYGGGGDGGTNRFDRVLHEVQHLVGEFVVSDYFPWMWWVNKLNGMETRVEKNFEELDKLYDEVIADHVAPTRTKANHEDIVDVLLRLQKDARQLITLNNQQIKGVLTDMFIAGTDTTASSLVWTFTELIRNPPSMEKVKYEVRKVGNGRDKIEESDIPKLHCLHSVIKETLRLHPPAPLLVPRETTEDCVVGDYEIPAKTRVIINAKSIGTDPKYWENPHDFQPDRFMKSSVDFKGQHLEFLPFGVGRRGCPGMSFAIMLLQLMVANFLYRFDWELPEGMSVEDVDMEEELGITVFKKTPLCLVPIRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PMX5</accession>
    <name>A0A0D2PMX5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein bL25 beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G073500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PMX5"/>
    <dbReference type="STRING" id="29730.A0A0D2PMX5"/>
    <dbReference type="Gramene" id="KJB47477">
        <property type="protein sequence ID" value="KJB47477"/>
        <property type="gene ID" value="B456_008G073500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB47479">
        <property type="protein sequence ID" value="KJB47479"/>
        <property type="gene ID" value="B456_008G073500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763344"/>
    <dbReference type="eggNOG" id="ENOG502QV9D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMPICKI"/>
    <dbReference type="OrthoDB" id="193674at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.20:FF:000006">
        <property type="entry name" value="Ribosomal protein L25/Gln-tRNA synthetase, anti-codon-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="entry name" value="Ribosomal protein L25, beta domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_bL25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_bL25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_uL5_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25/GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33284:SF2">
        <property type="entry name" value="RIBOSOMAL PROTEIN L25_GLN-TRNA SYNTHETASE, ANTI-CODON-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL25 beta" evidence="1">
        <location>
            <begin position="143"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB47477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="237" mass="26708" checksum="6F1FBE5BA15E9F35" modified="2015-04-29" version="1">MLRLWRGLKTVVQTSPANTHHYHTIQAIPRECTGSRISSRDRAQGRIPAVVFSQGLLEKNPSNRSPSRKQILTTERKQIRSIIKSVQLPFFCSTRFQLQIRAGSGSSVLLESGTVLPIKIHRDEESGKILNLVFVWADEGTELKVDVPVVFKGLEDCPGLKKGGYFKMIRSSLKFQCPAEHIPQKIEVDVSKSDIDDRVLMHDIEVHPSMKLLSKNESMPICKIAPTYIENPEPIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PP60</accession>
    <name>A0A0D2PP60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G051200</name>
        <name evidence="11" type="ORF">Gorai_008910</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0591918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PP60"/>
    <dbReference type="Gramene" id="KJB48037">
        <property type="protein sequence ID" value="KJB48037"/>
        <property type="gene ID" value="B456_008G051200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763088"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVGMKWA"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000035">
        <property type="entry name" value="Cationic amino acid transporter 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF22">
        <property type="entry name" value="CATIONIC AMINO ACID TRANSPORTER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13520">
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    </dbReference>
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    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="318"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="9">
        <location>
            <begin position="509"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB48037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0591918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="585" mass="64368" checksum="4B92A000084F9E81" modified="2015-04-29" version="1">MSYIGKEDEVQQRPYWRWSKVDFLPEESFQNWNTYLSALSQIYSRFNDRLLSRSDDANEITQLRKQSENDMKRCLTWWDLTWFGFGSVIGAGIFVLTGQEAHHHAGPAIVLSYVASGISAMLSVFCYTEFAVEIPVAGGSFAYLRIELGDFVAFITAGNILLESIVGGAAVARAWTSYFATLLNRQPDSLRIPKGNYLLDPIAVAVLAIAATIAMISTKKTSQLNWIATALNTLVILFVLIAGFAHANTSNLTPFLPHGAKGIFQAAAIVYFAYGGFDSIATMAEETKNPSRDIPLGLLGSMSIITVVYCLMALSLSMMQKYTEIDPNAAYSTAFQSVGMKWAKYLVALGALKGMTTVLLVGALGQARYTTHIARAHMIPPWFALVHPKTGTPINATLLMTISSGLIAFFSSLDVLASLLSVSTLFIFMMMAVALLVRRYYVREVTPGINQLKLVIFLLVIIASSMGTSAYWGLRPNGWVGYVVTIPLWFLGTMGVSIFLPQQRTPKVWGVPLVPWLPSLSVAINIFLMGSLGPPAFIRFGICTVAMLVYYILVGVHATYDMAHQQQKLDSLKVKNEDEDKEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PP90</accession>
    <name>A0A0D2PP90_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF668 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G075500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB28916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2PP90"/>
    <dbReference type="Gramene" id="KJB28913">
        <property type="protein sequence ID" value="KJB28913"/>
        <property type="gene ID" value="B456_005G075500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28916">
        <property type="protein sequence ID" value="KJB28916"/>
        <property type="gene ID" value="B456_005G075500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797000"/>
    <dbReference type="eggNOG" id="ENOG502QQVZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2020544at2759"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045927">
        <property type="term" value="P:positive regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DUF3475"/>
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        <property type="entry name" value="DUF668"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045021">
        <property type="entry name" value="PSI1/2/3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31730">
        <property type="entry name" value="OS01G0873900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31730:SF32">
        <property type="entry name" value="PROTEIN PSK SIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11961">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3475" evidence="3">
        <location>
            <begin position="162"/>
            <end position="218"/>
        </location>
    </feature>
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            <begin position="383"/>
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    </feature>
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            <begin position="42"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05003"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF11961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB28913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="72620" checksum="9C2B1D3D9E87FCA6" modified="2015-04-29" version="1">MGGLCSRRSTVDNAPVGGFPHVNGHFARGSGLVFQTRQLPAKISTNSAPPAEDSADNAGMESREPFSFPEISTVPYCMNPAGIDDGIPRLSRVLSNKSRSTKSKQAAVAKVTEVGSRLGRAGTAGFGKAVDVLDTLGSSMTNLNLGSGFTSGVTTKGNKISILSFEVANTIVKGANLMQSLSMENIRHLNEMVLKSEGVQNLISRDMDELLRIAAADKREELKIFSGEVVRFGNRCKDPQWHNLDRYFEKLGSELTFEKQLKEEAETIMQQLMTYVHYTAELYHELHALDRFEQDYRRKLQEEDNSNTAQRGDSLAILRAELKSQNKHVKNLKKKSLWSRILEEVMEKLVDIVHFLHLEIHEAFGAADGDKPVKGSVSSHKKLGTAGLALHYANIITQIDTLVSRSNSVPPNTRDSLYQGLPPTIKSALRSRLQSFQLKEELTVPQIKAEMEKTLQWLVPIATNTTKAHHGFGWVGEWANTGSEMNRKPAGQTNLLRIETLHHADKEKTEVYILDLVVWLHHLVTQVRAGNGGIRSPVKSPIRSPNQKTVQLSTQKQSPSSMLTVEDQEMLRDVSKRKKAPGISKSQEFDTAKTKLIKHHRLSKSTSHSPTSESKKDPFLIRRLSSVPFIDFDINRIKALDVIDRVDTLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUG5</accession>
    <name>A0A0D2PUG5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative plant transposon protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G202400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUG5"/>
    <dbReference type="Gramene" id="KJB10459">
        <property type="protein sequence ID" value="KJB10459"/>
        <property type="gene ID" value="B456_001G202400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046796">
        <property type="entry name" value="Transposase_32_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20167">
        <property type="entry name" value="Transposase_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative plant transposon protein" evidence="1">
        <location>
            <begin position="39"/>
            <end position="209"/>
        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <sequence length="241" mass="28296" checksum="A81FC48CCADC2AAA" modified="2015-04-29" version="1">MYNSVKPDTIDVEKKALNTMKVNSQHQVKIGKPSEDVPVVPSVLHEFYANLKFFEEDKVYVRGREVEISPSIISKYYRVLFLANNEIELLETRNFKGVNVDYIILYLTEGKGEWEREVYTNLPISFNPILFTTLDKIWLHFLRMKVCPTSSSRIVNPFQDILLTAILQRKQIFIGTWIYKFMLRCVIRDDTGVFFPHLITDLCRAARVPIDPLKPFRQPTTHMITSSIYQKFKVIQQEQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0A0</accession>
    <name>A0A0D2Q0A0_GOSRA</name>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>Malvales</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q135</accession>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Jin D."/>
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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    <dbReference type="STRING" id="29730.A0A0D2Q135"/>
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        <property type="gene ID" value="B456_008G243000"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0593399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="388" mass="41371" checksum="F79E0D88B2B24CAC" modified="2015-04-29" version="1">MDPSEDGGTSDLSTSTGGPNNATPTAANSIKNDENCENSALMVMPLKEEPIEPDPDRKTHPPRPTRVVPVSGQMSMQIPIPTPVTTAKRSYNKDRHTKVEGRGRRIRIPATCAARIFQLTRELGHKSDGETVRWLLEHAEHAIIEATGTGTVPAIAVSVGGTLKIPTTSATNTSNNNSQIDDKTKKRKRPASSEFCDVNDGIPIAVAQQQQQQQRLVTQYSGLAPVAQQALVPVWAVGNTGMMVPANAFWMIPQSTPTASGDWLTNQRPPPQLWAFSPALTSVCNIAARPTSSFVATTTETQAVVCDGVSTLAVSTSSTPVGATEAKKSTMAPSVSSGGNGGGGTGGTAQMLRDFSLEIYDKQELQLMGRSWNHHQQQIKAASKQKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q1X7</accession>
    <name>A0A0D2Q1X7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_006G016800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q1X7"/>
    <dbReference type="STRING" id="29730.A0A0D2Q1X7"/>
    <dbReference type="Gramene" id="KJB33547">
        <property type="protein sequence ID" value="KJB33547"/>
        <property type="gene ID" value="B456_006G016800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB33548">
        <property type="protein sequence ID" value="KJB33548"/>
        <property type="gene ID" value="B456_006G016800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798185"/>
    <dbReference type="eggNOG" id="KOG0996">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000003">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="15">
        <location>
            <begin position="557"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="204"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="723"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="930"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB33548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1245" mass="142010" checksum="469C05D09A7CBC51" modified="2015-04-29" version="1">MGMETKDEFATREPDRAQVGSRGPRLVINEMVMRNFKSYAGEQRVGPFHKSFSAVVGPNGSGKSNVIDAMLFVFGKRAKQMRLNKVSELIHNSTNHQNLDSAGVSVHFQEIIDLDDGTYEAVPGSEFVISRVAFRDNSSKYYINNRASNFTEVTKKLKGKGVDLDNNRFLILQGEVEQISLMKPKAQGPHDEGFLEYLEDIIGTNKYVEKIDESSKELESLNEKRSGVVQMVKLAEKERDSLEDVKNEAEAYMLKELSLLKWQEKAAKLAHEDTSLKMVELRENVSNVEENLKNKREEIQESSKRLKEIESVHNKHLIRKEELDNDLRTCKEEFKEFERQDVKYREDLKHMKQKLKKLEDKLEKDSSKIEDVSKECENSKNLIPKLEENIPKLQKLLLDEEKVLEEMKENSKVETEKYRSELSKVRAELEPWEKELIVHKGKLEVAHTERNLLTQKHEAANTAFKDAQKEMDNILGKTETITAAVKDKQTDLEKNKLGALEARKLEQTCIKEQEALIPLEQAAREKFAELKSVLDSEKSQGSVLKAILQAKESKQIEGIYGRMGDLGAIDAKYDVAISTACPGLDYIVVETTAAAQACVELLRREQLGIATFMILEKQLDLLERSKEKVRTPEGVPRLYDLIKVQDERIKLAFYAALGNTIVAKDLDQATRIAYGGNKEFRRVVTLDGALFEKSGTMSGGGSKPRGGKMGTSIRAASVSRETVVAAEKELANMVDSLNNIRQRIADATRRYQASEKVVAELDMEIAKSQKEVDSLNSEYKYLEKQLDSLEAASRPKKDEIDRLEELKKIISTEEKEIDRLIQGSKKLKEKASDLQNKIENAGGEKLKTQKSKVEKIQSDIDKNSTEINRHKVQIETGEKMVKKLTKGIEESKKEKERIIEGKDKMHGMFKEIEQKAFIVQDNYKKMQKVIDEHGEVLEKSKLEYEKVKKNVDQLRASEVDADFKLQDMKKMYKELEMKGKGYKKKLNDLEISLQKHMEQIQKDLVDTEKLQATLADETLTEACDLKRALEMVTLLETQLKEMNPNLDSISEYRNKVSVYNERVDDLNTVTQQRDDIKKQYDELRKKRLDEFMAGFNAISLKLKEMYQMITLGGDAELELVDSLDPFSEGVVFSVRPPKKSWKNIANLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFKNVSIVGHYVKDRTKDAQFIIISLRNNMFELADRLVGIYKTDNCTKSITINPNSFVVCEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q1Z8</accession>
    <name>A0A0D2Q1Z8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Granule-bound starch synthase 1, chloroplastic/amyloplastic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Granule-bound starch synthase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_008G260100</name>
        <name evidence="15" type="ORF">Gorai_010477</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; starch biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q1Z8"/>
    <dbReference type="STRING" id="29730.A0A0D2Q1Z8"/>
    <dbReference type="Gramene" id="KJB52402">
        <property type="protein sequence ID" value="KJB52402"/>
        <property type="gene ID" value="B456_008G260100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765362"/>
    <dbReference type="eggNOG" id="ENOG502QQX3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="UniPathway" id="UPA00152"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009501">
        <property type="term" value="C:amyloplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019252">
        <property type="term" value="P:starch biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03791">
        <property type="entry name" value="GT5_Glycogen_synthase_DULL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000073">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000090">
        <property type="entry name" value="Starch synthase, chloroplastic/amyloplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC/AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45825:SF3">
        <property type="entry name" value="GRANULE-BOUND STARCH SYNTHASE 1, CHLOROPLASTIC_AMYLOPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0750">Starch biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Starch synthase catalytic" evidence="13">
        <location>
            <begin position="84"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB52402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0593537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="608" mass="67130" checksum="5FF80F2F983A093D" modified="2015-04-29" version="1">MATVTASHLVSTVCQVNSHGADTKAANLICMKNQAAMTHNGLRFLNMLDRLQMRTNAKAVARQAVKQENPRPWGKIICGKGLNLVFVGAECGPWSKTGGLGDVLGGLPPAMAANGHRVMTVSPRYDQYMDAWDTSVLVEVKVGDKIETARFFHCYKRGVDRVFVDHPMFLEKVWGKTGSKIYGPNAGVDYKDNQLRFSLLCQAAMEAPKVLNLNSNRYFSGPYGEDVIFIANDWHTGLLPCYLKSMYQSRGIYMNAKVAFCIHNIAYQGRFPFSDFSVLNLPDRFKSSFDFFDGYPKPIKGRKINWMKAGILESDKVLTVSPYYAQELISGEDKGVELDNIIRKTGITGIVNGMDVQEWNPATDQHINVQYDASTVMDAKPILKESLQAEMGLHCDRNVPVVGFIGRLEEQKGSDVLAEAIPRFIRENCQIVILGTGKMAMEEQIENLETQYPDKARGIANFNVPLAHKIIAGSDFILIPSRFEPCGLIQLHAMRYGTVPIVASTGGLVDTVKEGFTGFQMGAFNVECDAVDPSDLDKVAKTVRKALATYGTPTMNEMIQNCMAQDLSWKGPSKLWEKLLLSLEVAGSEPGNEGEEIAPLAKENVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAE3</accession>
    <name>A0A0D2QAE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G097300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QAE3"/>
    <dbReference type="STRING" id="29730.A0A0D2QAE3"/>
    <dbReference type="Gramene" id="KJB13846">
        <property type="protein sequence ID" value="KJB13846"/>
        <property type="gene ID" value="B456_002G097300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781514"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFKERDS"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000008">
        <property type="entry name" value="Cytochrome P450 71D8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF8">
        <property type="entry name" value="CYTOCHROME P450 71D11-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58015" checksum="21C31D4B9D66DD56" modified="2015-04-29" version="1">MDNQFKMLPLSFTFLLFIFMVLKLWMRSKKKDSPKNLPPAPLKLPLIGHLHLLMVSLPHHRLTELAKRHGSLMHLQLGELSHIVVSSPEAAKEVMKTHDINFANRPYLLAAEIMLYNFSDIGFTPYGSHWRQLRKVCTLELLSTKRVQSFRSIREEEVSSLITSIFCNTGSEINFGELLCNLSYNITLRTTLVGRCKLQHETFIPIVKEFVEALGGFSITDLFPSIKLLPMISGMRTKLERCHHDLDMMLESIIEEHRASHANLGNSDDETDDLLDVLLNLQDHGGLEFPLTTENIKAVILDMLIAGTETSSTAVEWAMSEMMKNPRILEKAQAEVRQVYDRTGEVNESDLHELKYLKLVIKETLRLHPPLPLLIPRENSERCEINGYEIPAKTKVIVNAWAIGRDSNYWSEAERFNPERFIHSSVDYKGANFEFIPFGAGRRMCPGMSYGMAVVELSLAQLLYHFDWKLPNGMKNEDLDMTEAFGASVRRKSNLYLIPIPYRPACAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKH1</accession>
    <name>A0A0D2QKH1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-coenzyme A oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_007G028900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the acyl-CoA oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QKH1"/>
    <dbReference type="STRING" id="29730.A0A0D2QKH1"/>
    <dbReference type="Gramene" id="KJB39743">
        <property type="protein sequence ID" value="KJB39743"/>
        <property type="gene ID" value="B456_007G028900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801965"/>
    <dbReference type="eggNOG" id="KOG0136">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNMYNVL"/>
    <dbReference type="OrthoDB" id="538336at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003997">
        <property type="term" value="F:acyl-CoA oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005504">
        <property type="term" value="F:fatty acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033540">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA oxidase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001676">
        <property type="term" value="P:long-chain fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000015">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000005">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000013">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000075">
        <property type="entry name" value="Acyl-coenzyme A oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055060">
        <property type="entry name" value="ACOX_C_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029320">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012258">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002655">
        <property type="entry name" value="Acyl-CoA_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909">
        <property type="entry name" value="ELECTRON TRANSPORT OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10909:SF250">
        <property type="entry name" value="PEROXISOMAL ACYL-COENZYME A OXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01756">
        <property type="entry name" value="ACOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22924">
        <property type="entry name" value="ACOX_C_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14749">
        <property type="entry name" value="Acyl-CoA_ox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000168">
        <property type="entry name" value="Acyl-CoA_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-coenzyme A oxidase N-terminal" evidence="14">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-alpha1" evidence="15">
        <location>
            <begin position="278"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase C-terminal" evidence="13">
        <location>
            <begin position="480"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000168-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB39743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="664" mass="74621" checksum="2737BD24CA5680D0" modified="2015-04-29" version="1">MEALDYHAEERRKAEFDVEEMKIVWAGSRQAYEISDRVARLVASDPVFRKDNRTMLSRKDLFKDTLRKAAHAWKRIIELRLSEEEASKLRFFVDQPVFTDLHWGMFIPAIKGQGNEEQQQKWLPMAYKMQIIGCYAQTELGHGSNVQGLETTATFDPETDEFVIHSPTLTSSKWWPGGLGKVSTHALIYARLITDGQDHGVHGFIVQLRSLDDHLPLPGITVGDIGMKFGSGAYNSMDNGVLRFDHVRILRDQMLMGVSQVTREGKFMQSDVPRQLVYGTMVYVRQKIVADASCALSRAVCIATRYSVVRRQFGSHNGGPETQVIDYKTQQSRLFPLLASAYAFRFVGEWLKWLYTDVTQRLQASDFSTLPEVHACTAGLKSVTTSATADAIEECRKLCGGHGYLSSSGLPELFAVYVPACTYEGDNVVLLLQVARFLMKTVSQLGSGKKPVGTIAYMGRSEHLLQCRCEVERAEDWLKPNVILEAFEARAARMSVTCAKNLNNFANQEEGFAQLATDLAEAAVAHVQLIIVSKFIEKLQQDIPGKGVKRQLEILFNVYALSLLHKHLGDFVASGCITPKQGALANEQLRLLYSQVRPNAIALVDAFNYTDHFLGSVLGRYDGNVYPKLYEEAWKDPLNETVVPDGYHEYIRPILKQHIRVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLQ1</accession>
    <name>A0A0D2QLQ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_003G161000</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLQ1"/>
    <dbReference type="STRING" id="29730.A0A0D2QLQ1"/>
    <dbReference type="Gramene" id="KJB20719">
        <property type="protein sequence ID" value="KJB20719"/>
        <property type="gene ID" value="B456_003G161000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SSHGHEE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000217">
        <property type="entry name" value="E3 ubiquitin-protein ligase At1g12760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF28">
        <property type="entry name" value="OS02G0674700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB20719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="389" mass="43698" checksum="9AE9DD0CCE6530C5" modified="2015-04-29" version="1">MTSTTPTNRSSADDITNTTPFLSSTTTVSRSDSATRPSVRRQSLREAARFMRRATSRRTMREPSMLVRETAAEQLEERQSDWAYSKPVVILDVIWNFAFVAVAVGVLFLSRDENPEMPLRLWIIGYAFQCLLHMVCVCVEYKRRRRRQSMDYSPFNAGEDGVLSSGSGVESEQYVTFAQLEEDNGSNVAKHLESANTMFSFVWWITGFYWVSLGGQALARGSPQLYWLCIIFLAFDVFFVVFCVALACIIGIAVCCCLPCIIAILYAVADQVTFESYLHEGASKEEIDQLSKFKFQKNGDNEKPAGDVQGPVGGIMIECGTDSPMEQVLSQDDAECCICLSAYEDGVELRELPCRHHFHCACVDKWLYINATCPLCKYNILKSSSQEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QPZ8</accession>
    <name>A0A0D2QPZ8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G288400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QPZ8"/>
    <dbReference type="STRING" id="29730.A0A0D2QPZ8"/>
    <dbReference type="Gramene" id="KJB60077">
        <property type="protein sequence ID" value="KJB60077"/>
        <property type="gene ID" value="B456_009G288400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RSKANFC"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009511">
        <property type="term" value="C:plasmodesmatal endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048574">
        <property type="term" value="P:long-day photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009663">
        <property type="term" value="P:plasmodesma organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009911">
        <property type="term" value="P:positive regulation of flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd08378">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04019">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000128">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047257">
        <property type="entry name" value="C2B_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047258">
        <property type="entry name" value="C2C_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF22">
        <property type="entry name" value="MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="297"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="455"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="10">
        <location>
            <begin position="621"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="895" mass="102277" checksum="981F97EE9FFFE767" modified="2015-04-29" version="1">MSKLVVEVVDAYDLMPKDDQGSSSPFVEVEFDGQRQRTQTKHKDLNPSWHESLVFDISQPGDLEYKTIDVTVYNDRKGNHGHHRNFLGRVKISGASVPSSESGSSVQHYPLDKRGLFSNIKGEIALKLYQVCDELPREQVQRAAPASVVAENEETGRFQESQFNETPFQEINGGRVQESQFQETPFQEINNVNNFDEEIKVDEKKKKKKKKEPEVRTFHSIGKEPEVRTFHSVGTGTGGPPPAPPPMKEKPPAVEIRADFAKAAAPAASVMHMQMPRQNPDYLLVETRPPVAARLRYRGGDKTLTTYDLVEQMHYLYVNVVKAKDLPVMDMSGSLDPYVEVKLGNYKGQTKHLEKNQNPVWHQIFAFSKERVQSNLLEVVVKDKDFGKDDFVGKIVFDVMEIPLRVPPDSPLAPQWYRLADKKGDKVKGEIMLAVWMGTQADESFPEAWHSDAHNISHSNLANTRSKVYFSPKLYYLRVHVMEAQDLVPHDKGRLPDPYVKVVLGNQIRPTKVIQRTIHPVWDDQLMFVASEPFEDYIIVSVDDRIGPGKDEILGRAMIPVREVPQRLETGKPPDPRWFNLLKPSKAEEEGEKKKEKFSSKILLRIFLEAGYHVLDESTHFSSDLQPSSKFLRKQSIGILELGILSAKNLQPMKMKDGKLTDAYCVAKYGNKWVRTRTLLDTLSPRWNEQYTWEVHDPCTVITIGVFDNSHTNGSKDDARDQRIGKVRVRLSTLEIDRVYTHYYPLLVLTPGGLKKNGELQLALRFTCTAWVNMVAQYGRPLLPKMHYVQPIPVMNIDWLRHQAMQIVAARLQRAEPPLRREVVEYMLDVDYHMWSLRRSKANFNRIMSLLSGVTAICKWFNDICYWRNPITTCLTKTSPTYGCSAFTSGSYTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQM0</accession>
    <name>A0A0D2QQM0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G301600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQM0"/>
    <dbReference type="STRING" id="29730.A0A0D2QQM0"/>
    <dbReference type="Gramene" id="KJB60357">
        <property type="protein sequence ID" value="KJB60357"/>
        <property type="gene ID" value="B456_009G301600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770658"/>
    <dbReference type="eggNOG" id="ENOG502QSPX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AEIHYPT"/>
    <dbReference type="OrthoDB" id="660305at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34466">
        <property type="entry name" value="OS11G0129800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34466:SF3">
        <property type="entry name" value="OS11G0129800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="18"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="568" mass="62285" checksum="353910EBC368D548" modified="2015-04-29" version="1">MVVSSTFESSLRRGNPTSRKAAPSSSESSKSAAAAPPRRSRSVSAFSRTSSSDFSGFSIKRDNPLFVNTTNHNNSNSTSNDEDDDDSGALFPNSGFKSDRITSKTKPKAVAAGDYNNRRGRPVSRTGSDGKQWSGSGNSISKESSRSLSVVDTRRRGRSVSRTPLSRTNVATSESEVEQEGNSWMKSKNKGNLSATSGNGQKGNSAQSRSSLTRSGHRKPTDPLDASPTSLSRLETAKWNDSVSTSSFSEAELMESFQGENLVGDATAASDIYRTVKSEVRRAISDIQNELQGAIRSNATTNRVELASDIQHEYATKLEQSQERARQLRADLAVEEHRGMELSRILKEVLPDAKTPSTKKSHPRRKTSIERRKISKCLTDDALAYFDECVSLSTFDGSDFSSIEDPPLKCVGTVDVDGVSLPHANSSIPSTNFPSSYLHDKQEGPFTYNHDVSGLTSGDGIMEQNSIDCEWNRKFQFSFSPKPGSLCELQQDIKKYVKGFEKDTGKIDVDSRIKQRNSYDREEYNLLGSQQSLLFDHVFLKNRLDTGSLHLCNGGCFSASFLPFASLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QUM6</accession>
    <name>A0A0D2QUM6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G231400</name>
        <name evidence="14" type="ORF">Gorai_021724</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QUM6"/>
    <dbReference type="STRING" id="29730.A0A0D2QUM6"/>
    <dbReference type="Gramene" id="KJB10905">
        <property type="protein sequence ID" value="KJB10905"/>
        <property type="gene ID" value="B456_001G231400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804468"/>
    <dbReference type="eggNOG" id="ENOG502SPQG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNFVNCE"/>
    <dbReference type="OrthoDB" id="985850at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF216">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAC" evidence="12">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0579468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="402" mass="45641" checksum="6EA07A459CABA1DB" modified="2015-04-29" version="1">MNTVKGFRFHPTDEELIEYLLLETFGVDRDSLVQVIDQVPDICQWEPWQLAESSQLQTGDRLWYFIYAPTYKYRNSKRISRTTREGYWKPTGNARKIIDPQTGEVIGTKKTLVFYKGQCNDKYKIKTCWVMHEYELVAAPNSIDIDQKTFNLCKLKKRVDISCTDAGQSSQHKDCDDVVHNQSGIKSYAGDRSNQHNIANDGVVSNLSSHDLDDAIPKENLHERSKECNEPEGNSGVQKLNSIIEKDDKSCSSVLTDGDETITVERSDQHNVVVAAEGFGIPSSFEYFDYEVLIPAEFFYNDGLWYDELLEVPEATNNSNWIQDQSINNTEDVEFLNSIIVDNDEAYLLEENRPHPSAADNEVLGAVGSSDLMEKPSKRLRLSHDDHVETTEARAGGSITYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QV27</accession>
    <name>A0A0D2QV27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Metallothionein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G389000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallothionein superfamily. Type 15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QV27"/>
    <dbReference type="Gramene" id="KJB61892">
        <property type="protein sequence ID" value="KJB61892"/>
        <property type="gene ID" value="B456_009G389000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7B3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QCKCGST"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044671">
        <property type="entry name" value="MT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33357">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33357:SF3">
        <property type="entry name" value="METALLOTHIONEIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0480">Metal-thiolate cluster</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB61892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="6585" checksum="6F7FB58238DB8A6B" modified="2015-04-29" version="1">MADKCGNCDCSDKSQCVKKGNALVIETEKSYISTVVVEAVAENDGKCKCGTSCSCTNCTCGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVZ4</accession>
    <name>A0A0D2QVZ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="5">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G196100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="5"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVZ4"/>
    <dbReference type="STRING" id="29730.A0A0D2QVZ4"/>
    <dbReference type="Gramene" id="KJB43358">
        <property type="protein sequence ID" value="KJB43358"/>
        <property type="gene ID" value="B456_007G196100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803728"/>
    <dbReference type="eggNOG" id="KOG1372">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HWQTVNY"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000102">
        <property type="entry name" value="GDP-mannose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="9">
        <location>
            <begin position="31"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="373" mass="42009" checksum="6845D031286FBF0F" modified="2015-04-29" version="1">MATENNSSRVGSGSGSYTVNGDAAPDRKIALITGITGQDGSYLTEFLLNKGYEVHGLIRRSSNFNTQRINHIYIDPHNAHKARMKLHYADLTDASSLRRWLDTIRPDEVYNLAAQSHVAVSFEIPDYTADVVATGALRLLEAVRSHIAATGRTHIKYYQAGSSEMFGSTPPPQSEHTPFHPRSPYAASKCAAHWYTVNYREAYGLFACNGILFNHESPRRGENFVTRKITRAVGRIKIGLQNKLFLGNLQASRDWGFAGDYVEAMWMMLQQEKPDDYVVATEESHTVEEFLQVAFGYVGLNWKDHVVIDKRYFRPAEVDNLKGDSSKARKVLGWKPKVGFEQLVKMMVDEDIELAKREKVLVDAGYMDAQQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R559</accession>
    <name>A0A0D2R559_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G275700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB27069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_004G275700"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0D2R5B7</accession>
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        <name type="common">Peruvian cotton</name>
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            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_002G131800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SFD6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 2"/>
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    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
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    </dbReference>
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        <location>
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            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB14570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="200" mass="22846" checksum="C335CCE1DD7F83BA" modified="2015-04-29" version="1">MKKTYAKARDVDEVDANATSIFLGFQRVLDLSKYLTVPLFHKYRDKKSTFQFIIYKVHGRVVIYIKNIFGELEGFFTMMHIFSSITSTQNSNLDDGAFVPKGIDKACPRATWPATGKKRASVPITEEQVRGIFHRYDTNRDGLLSKQELKNAFSSLGSRMPGVRAWLALQHADVNGDGYINEAEFDKLVKYTLKRGYKFN</sequence>
</entry>
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    <accession>A0A0D2R5R3</accession>
    <name>A0A0D2R5R3_GOSRA</name>
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            <fullName evidence="2">Neprosin PEP catalytic domain-containing protein</fullName>
        </recommendedName>
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    <gene>
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    <organism evidence="3 4">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>rosids</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G288000"/>
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        <property type="entry name" value="ASLB (DUF239)-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31589">
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    </dbReference>
    <dbReference type="PROSITE" id="PS52045">
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        <location>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002250283" description="Neprosin PEP catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Neprosin PEP catalytic" evidence="2">
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        </location>
    </feature>
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        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB27269.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="420" mass="47216" checksum="8F5C94A1D5442499" modified="2015-04-29" version="1">MANFIFRVLLTLVLSYLCNRVNGKANFKEIDEKLKQLNKPAVKTIQSEDGDIIDCVDIYKQPAFDHHALKNHIIQMKPSFDLKEERLSSKNESTKLAIFQTWQKSGSCPEGTVPIRRIRRGDLLRAKSVQQFGRKPHEVVLKSNTTVEHKDGQLPSINTTALAMPVIVNRSAATLVTVGYNYIGAKADINVWTPNVEAQDEYTTAQIWLKAGPGDNFESIESGWTVNPQLYGDKRTRLFAHWTKDSYKTTGCFDMTCSGFVQTSSQYLLGGSIEPVSTEFGQQYDLTVGIYMDPNTANWWLKIGKDIPVGYWPASTLLFYLNHSSTLVEWGGQVYSSNVKKKPHTKTGMGSGQFASGLRGNACYMDNIAIVDFSMQLKYPQWVGTWADEQYCYTALNYQEGYGTLPIFYFGGPGQNYNCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R776</accession>
    <name>A0A0D2R776_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G185800</name>
        <name evidence="11" type="ORF">Gorai_015080</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R776"/>
    <dbReference type="STRING" id="29730.A0A0D2R776"/>
    <dbReference type="Gramene" id="KJB25326">
        <property type="protein sequence ID" value="KJB25326"/>
        <property type="gene ID" value="B456_004G185800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791936"/>
    <dbReference type="eggNOG" id="ENOG502RY2R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNLMSPC"/>
    <dbReference type="OrthoDB" id="1708403at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052426">
        <property type="entry name" value="Plant_dev_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801:SF5">
        <property type="entry name" value="OS05G0286100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45801">
        <property type="entry name" value="OS07G0101800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB25326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0584258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="215" mass="23662" checksum="5065E48F716F0CBE" modified="2015-04-29" version="1">MAADLRLLSLTQLQKLAQSQHNQNLMAASWVWNPQEAADDDSWEVRAFAQDTGNVMGTTWPPRSYTCTFCRREFRSAQALGGHMNVHRRDRARLHQTHPPAPTVPLINQTSSSTTQDFVSDGGLCLLYQIPTPNGAFNSPSMNPCSLDSTSPLLSMSPYPSNNLMAPPPPPYINYPATPPGLHNSSSADNNICSMETSIEELDLELRLGQRPTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAD6</accession>
    <name>A0A0D2RAD6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G071500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAD6"/>
    <dbReference type="STRING" id="29730.A0A0D2RAD6"/>
    <dbReference type="Gramene" id="KJB28794">
        <property type="protein sequence ID" value="KJB28794"/>
        <property type="gene ID" value="B456_005G071500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28795">
        <property type="protein sequence ID" value="KJB28795"/>
        <property type="gene ID" value="B456_005G071500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000182">
        <property type="entry name" value="PTI1-like tyrosine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052101">
        <property type="entry name" value="Plant_StressResp_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47983">
        <property type="entry name" value="PTO-INTERACTING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47983:SF49">
        <property type="entry name" value="RECEPTOR-LIKE CYTOPLASMIC KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="169"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB28794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="386" mass="42700" checksum="4B01AD748260FC6E" modified="2015-04-29" version="1">MLIHKQKRVEGKKLMKEGKTKFYRTPLCTIATLFSPYVSCPCHIIIIIINGCSKCKWYMSALPGKRIQSILNYVQVANSDQTPQTHSLYVFADFQGKRNMSCFSCCEEDDIHKASGNGSFMANTPASNSGGHGYQAREAVTRDPRPVTIQPIAIPAITVDELKEMTDNFGMKSLIGEGSYGRVYYGILKSGNAAAIKKLDSSKQPEQEFLAQVSMVSRLKDENVVQLLGYCVDGSLRFLAYEYASNGSLHDRLHGKKGVKGAQPGPVLSWTQRVKIAYGAAKGLEYLHEKAHPHIIHRDIKSSNLLLFDDDVAKIADFDLSNQAPDATARLHSTRVLGTFGYHAPEYAMTGTLSSKSDVYSFGVILLELLTGRKPVEIRCHVDSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAX3</accession>
    <name>A0A0D2RAX3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G200500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Tdpoz family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAX3"/>
    <dbReference type="STRING" id="29730.A0A0D2RAX3"/>
    <dbReference type="Gramene" id="KJB67617">
        <property type="protein sequence ID" value="KJB67617"/>
        <property type="gene ID" value="B456_010G200500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773406"/>
    <dbReference type="eggNOG" id="KOG1987">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071472">
        <property type="term" value="P:cellular response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd14736">
        <property type="entry name" value="BACK_AtBPM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18280">
        <property type="entry name" value="BTB_POZ_BPM_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000136">
        <property type="entry name" value="BTB-POZ and math domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056423">
        <property type="entry name" value="BACK_BPM_SPOP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045005">
        <property type="entry name" value="BPM1-6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034090">
        <property type="entry name" value="BPM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379">
        <property type="entry name" value="BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR26379:SF293">
        <property type="entry name" value="BTB_POZ AND MATH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24570">
        <property type="entry name" value="BACK_BPM_SPOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="6">
        <location>
            <begin position="25"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="5">
        <location>
            <begin position="195"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB67617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45397" checksum="6A8CB60867ED58E9" modified="2015-04-29" version="1">MKKRKKSNMEDFKDSESKSVSETVNGSHQFTIKGYSLAKGMGAGKCIQSDIFTVGGYDWAIYFYPDGKNPEDSAMYVSVFIALASEGTDVRALFELTLIDQSGKGKHKVHSHFDRALESGPYTLKYRGSMWGYKRFFRRTTLESSDYIKDDCLIMNCTVGVVRTRLEGPKLSSIPVPPSDMGQNLRALLESEVGCDIMFQVGDETFKAHKLILAARSPVFKAQFFGLVGDPNLDKIVVKDFEPSIFKAMLLFIYTDKLPDVQEIVDSTSMCTSTNMVQHLLAAADLYNLDRLKVLCEAKLCEELNADTVATTLALAEQHHCAQLKAICLKFAATPSNLGAVMQSEGFKHLEECCPSLLSEMLKAFASSEESSSLLSSRKRSVSSVYGMDLAAEGPAAEPMNPNGRRVRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDY6</accession>
    <name>A0A0D2RDY6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G014400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDY6"/>
    <dbReference type="Gramene" id="KJB27881">
        <property type="protein sequence ID" value="KJB27881"/>
        <property type="gene ID" value="B456_005G014400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796369"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVCANIE"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000351">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000682">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g16610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015">
        <property type="entry name" value="OS07G0578800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015:SF1934">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="318"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="557"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="635"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB27881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="727" mass="81194" checksum="2E94F74779DA701F" modified="2015-04-29" version="1">MRHFPLNSITSKKRPLYLFNLKIRNSTNNGDFADTLKIYSSMLRDTPVHGNSFTFPLLFKACASLNSLHDGTKLHAHVLQLGFQQDIFVQTSLLDMYSKCSDLASARNVFDEMVMRNVVCWNTMISAYCRCFRVMEAMNLLKEMWVIGFELNASTFVSVIAACTNLRLGLSMHCCVFKLGLLHCEIPLANSVVNMYVKFGLIDDARSIFDTVDERSILSWTTIIGGYVSVGNVGEAFNLFNRMRQMGCVSQDMVLFVKIISGCVKSGNLLLASSVHSLVLKSGFHGEASIDNSVLNMYSKCGDIVSARRVFEMVDEKCIFLWTSMIAANTQHGYPAEALDLFKSLLRTDLKPNEATIASILSACADLGSLSIGNEIEHYVKLNGLASNQQVQTSLIHMYCKCGRIDKAEEVFAGVLHKDLAVWSSMINGYAIHGMGNEALKLFHRMQITKPCSLDHVVFTSILLACSHSGLVEDGLKYYKSMKDDYGIEPGIEHYTCLVDLLGRAGHFDLALKTIQEMPLQVQAQVWAPLLSSCRKHCKIELGEYVAKKLLDLNPGNTSSYVLMANIYTSAGKWKEAAKTRSMMRNKGLVKEPGWSQIEINGSVHVFMAGDRSHHRSAGIYEKLNELNTKLKEAGYVAETDMVVHDLENEEKEESMKVHSERLAVAWGLIGTEPGTTLTIIKNLQTCGDCHSFLKFTSKVTGRHLIVRDGQRFHHFQLGSCSCKDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFI3</accession>
    <name>A0A0D2RFI3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <ecNumber evidence="12">4.1.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_005G149100</name>
        <name evidence="19" type="ORF">Gorai_016785</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="12"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFI3"/>
    <dbReference type="STRING" id="29730.A0A0D2RFI3"/>
    <dbReference type="Gramene" id="KJB30564">
        <property type="protein sequence ID" value="KJB30564"/>
        <property type="gene ID" value="B456_005G149100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794279"/>
    <dbReference type="eggNOG" id="KOG0788">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CYQRKNE"/>
    <dbReference type="OrthoDB" id="1068353at2759"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099402">
        <property type="term" value="P:plant organ development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.50:FF:000001">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.90.10:FF:000002">
        <property type="entry name" value="S-adenosylmethionine decarboxylase proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.50">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001985">
        <property type="entry name" value="S-AdoMet_decarboxylase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00535">
        <property type="entry name" value="SAM_DCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF15">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001355">
        <property type="entry name" value="S-AdenosylMet_decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="4 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9 12" id="KW-0704">Schiff base</keyword>
    <keyword evidence="5 12" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5042319584" description="S-adenosylmethionine decarboxylase beta chain" evidence="17">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5042319585" description="S-adenosylmethionine decarboxylase alpha chain" evidence="17">
        <location>
            <begin position="69"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="13">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="13">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="16">
        <location>
            <begin position="68"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="15">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR001355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001355-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0586030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="355" mass="38482" checksum="3D43E2BBF2A7C110" modified="2015-04-29" version="1">MAVSAIGFEGYEKRLEISFFEPGIFADPEGKGLRALTKAQLDEILGPAECTIVSSLSNKQVDSYVLSESSLFVYPYKIIIKTCGTTKLLLAIPPILKLAGSLSLAVKSVRYTRGSFIFPGAQPFPHRNFSEEVAVLDNYFGKLGAGSKACVMGGLDKQKWHVYSASAEPVTATGPVYTLEMCLTGLDRDKASVFYKDQSGSAAVMTINSGIRKILPESEICDFEFEPCGYSMNAIEGDAISTIHVTPEDGFSYASFEAVGYNLKDKNLKQLVGRVLQCFKPSDFSVAVHVDVGGGQSLEQSCLLDVKEYCCGEMGIEGLASGGSMMYQKFKSTGGCGSPRSTLKCCWKEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RG10</accession>
    <name>A0A0D2RG10_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_003G034200</name>
        <name evidence="27" type="ORF">Gorai_024005</name>
    </gene>
    <organism evidence="26 28">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 28" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="27 29" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27">8</strain>
            <tissue evidence="27">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="27" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="27">8</strain>
            <tissue evidence="27">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0581839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RG10"/>
    <dbReference type="STRING" id="29730.A0A0D2RG10"/>
    <dbReference type="Gramene" id="KJB18105">
        <property type="protein sequence ID" value="KJB18105"/>
        <property type="gene ID" value="B456_003G034200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787720"/>
    <dbReference type="eggNOG" id="ENOG502R5E1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HIVEWVI"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050829">
        <property type="term" value="P:defense response to Gram-negative bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010102">
        <property type="term" value="P:lateral root morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060866">
        <property type="term" value="P:leaf abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000453">
        <property type="entry name" value="Leucine-rich receptor-like protein kinase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000417">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000275">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000233">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase TDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF35">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE HSL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="18 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12 24" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220061" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="26"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="682"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="710"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB18105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="MBA0581839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="988" mass="109519" checksum="69890F6582F2D7BD" modified="2015-04-29" version="1">MRNPDLKALICFLFWVVCVFTFVVSFNGDSQILIRVKDSQLDDPNGRLRDWVILTPDQSPCNWTGVRCESRNRTVASIDLSGFGISGGFPFEFCRIRTLRTLYLADNNLNGSLSSQAISPCFRLREIDLSGNIFVGELPDFLSEHLEVLELSNNNFTGDIPVSFGRMKSLKVLSLGGNLLNGKVPSFLGNLTELTDFALGYNPFKPSPLPDEIGNLSKLEYLWLTNANLVGEIPFSIGNLISLKSLDLTCNFLIGKIPESLSKLKKLEQIELYQNQLTGELPESLAELTSLLRLDVSQNSLTGKLPEKIAAMPLESLNLNDNFFTGEIPEVLASNQYLSQLKLFNNSFTGKLPSDLGKFSPLEDFDVSTNNFSGELPPFLCHKRKLQRVVIFTNRFSGSIPESYGECESLNYIRMGDNAFSGNVPEKFWGLPLMQLFELQNNHFEGSISPSISALQKLTILRISGNNFSGVIPEGMCKLHNLTQINLSQNRFSGGLPLCITDLKLQTLELEDNELTGNLPGSVGSWTELTELNLARNRFTGEIPPTLGNLPALIYLDLSGNLLIGKIPEDLTKLRLNRFNLSGNLLNGKVPSGFNNEFFISGLLGNPDLCSPNLNPLPPCPRIKPGTFYVVGILTVCLILLIGSVIWFFRTRSKFGSKTRRPYKVTLFQRVEFNEDEIFPFMKDDCIIGTGGSGRVYKVKLKTGQTVAVKRLWGVKREAEEVFRSETETLGRIRHGNIVKLLMCCSGDEFRVLVYEYMENGSLGDVLHGDKWGGLADWPKRFAIAVGAAQGLAYLHHDCLPPIVHRDVKSNNILLDEEMRPRVADFGLAKTLQIEAGDDGSNGGAMSRIAGTHGYIAPEYGYTLKVTEKSDVYSFGVVLLELITGKRPNDSSFGENEDLVKWVTEVVLSSLPPSASAQGGNDGGGYFGKKVAEIVDPRMMPSTYEMKEIERVLNVALKCTSAFPINRPSMRKVVELLKDQRCVQLVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGZ0</accession>
    <name>A0A0D2RGZ0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G0509001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGZ0"/>
    <dbReference type="Gramene" id="KJB18405">
        <property type="protein sequence ID" value="KJB18405"/>
        <property type="gene ID" value="B456_003G0509001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB18405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="69" mass="7759" checksum="52E94BA6AB203521" modified="2015-04-29" version="1" fragment="single">MNAPLVPSASLDETSISILTITLFGILGDSLEAFNADLDEELDFLQWIASSNSKNYQLWFFFIVPRFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RI75</accession>
    <name>A0A0D2RI75_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G071200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RI75"/>
    <dbReference type="STRING" id="29730.A0A0D2RI75"/>
    <dbReference type="Gramene" id="KJB70387">
        <property type="protein sequence ID" value="KJB70387"/>
        <property type="gene ID" value="B456_011G071200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YCANELC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000291">
        <property type="entry name" value="Protein phosphatase 2C 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="69"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB70387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="347" mass="38806" checksum="4054335772D741A4" modified="2015-04-29" version="1">METCEMTRKASRSRDMLLGLEERVVNLKDSLGDVKKTLEEVKRRIVELDLKEEQLNEVKRSCFLRIIGSSNSGSNCAFNIGKQRLAKPFDVRRIFVFKLFFEIVGGANVALVSNYCANELCRIVAEEWERGSSLDGWNKRWEVALCKAYERADNAFKDEALAPKSVGSTALVLIVSPCQIIAANCGDSRAVLCRGAQAIPLTVDQKPDRADELERITSSGGRILNWGCLRVEGILSMSRAIGDHDLKPWVISVPEVTFTTRTKEDECLILASDGLWDVLSNDDVVKLARKELRQRHRLAGANKSSFPPAWHVSQHVLKQALDAYSLDNISVIVVDLKNPKLKPQEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIM9</accession>
    <name>A0A0D2RIM9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">gibberellin 3beta-dioxygenase</fullName>
            <ecNumber evidence="9">1.14.11.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_011G078700</name>
        <name evidence="14" type="ORF">Gorai_005543</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the iron/ascorbate-dependent oxidoreductase family. GA3OX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.15" evidence="9"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0599319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIM9"/>
    <dbReference type="STRING" id="29730.A0A0D2RIM9"/>
    <dbReference type="Gramene" id="KJB70547">
        <property type="protein sequence ID" value="KJB70547"/>
        <property type="gene ID" value="B456_011G078700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778558"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AGKLMWL"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016707">
        <property type="term" value="F:gibberellin 3-beta-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009686">
        <property type="term" value="P:gibberellin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000013">
        <property type="entry name" value="Gibberellin 3-beta-dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="201"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB70547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0599319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="368" mass="40818" checksum="A9E852EBC6195E07" modified="2015-04-29" version="1">MPSRLSDAFRAHPQQQLKHPDFTSLHELPDSYAWNQRDDPSPETFATESVPLVDLNDPNALQVIGHACKTWGIFQVTNHGISTSLLDMVEHTCRSLFSLPVHQKLKAARSPDGVSGYGFARISSFFSKLMWSEGFTIVGPPDEHFCQLWPQDFSYHCDVIKEYKEEMKKLAGRLMWLMLGSLGIIAKEDIKWAGPKADFKEASAALQLNYYPACPDPDRAMGLAPHTDSTLLTILYQNSTSGLQVFKEGAGWVAVPPVPGGLVINVGDLMHILSNGSYQSVLHRAMVNRSHHRLSSAYLYGPPSTVEISPHPKLVGPTHPPLYRPVTWNEYLHTKAKHFNKALSSVRVCVPLNGLGDVNEQNNSVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLU1</accession>
    <name>A0A0D2RLU1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_005G149600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dimeric E1 enzyme. E1 activates RUB1/NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a RUB1-ECR1 thioester and free AMP. E1 finally transfers RUB1 to the catalytic cysteine of RCE1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLU1"/>
    <dbReference type="STRING" id="29730.A0A0D2RLU1"/>
    <dbReference type="Gramene" id="KJB30556">
        <property type="protein sequence ID" value="KJB30556"/>
        <property type="gene ID" value="B456_005G149600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794284"/>
    <dbReference type="eggNOG" id="KOG2016">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INDSCTE"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01493">
        <property type="entry name" value="APPBP1_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000263">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000337">
        <property type="entry name" value="NEDD8-activating enzyme E1 regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="8"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB30556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="524" mass="58199" checksum="46103532FDCCC780" modified="2015-04-29" version="1">MAEPKTKYDRQLRIWGEQGQAALEKASICLLNCGPTGSETLKNLVLGGVGSITIVDGSKVEFGDLGNNFMVDDSSLGQSKAKCVCSFLQELNDAVKAKFIEEYPEALIDTNPSFFSQFTLVVATQLVEESMVKLDRICRQENVMLIFARSYGLTGLVRICVKEHTVIESKPDHFLDDLRLNNPWPELRGFADAIDLNVQDPVAHKHIPYVVILVKMADEWKTSHGGTLPSTREQKREFKELLKARMAATDEDNYKEAIDASFKLFAPQGISSDLQQIINDSCAEVGSSSSDFWVMVAALKEFIANEGGGEVPLEGSIPDMTSSTEHYVNLQKIYQAKSEADYLVLEERVRNILKKIGRDPHSIPKATIKSFSKNARKLKVCRYRSIEDEYNNPSPAELHKYLTDEDYSIAVGFYILLRAVDRYAANFNHFPGQFDGGLDEDISRLKTTAVSLLNDLGCSGLTLTEDLINEMCRFGAAELHAVAAIIGGIASQEVIKLITKQFVPMTGTFAFNAIDHKSQLLNLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLX8</accession>
    <name>A0A0D2RLX8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G131200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLX8"/>
    <dbReference type="STRING" id="29730.A0A0D2RLX8"/>
    <dbReference type="Gramene" id="KJB20065">
        <property type="protein sequence ID" value="KJB20065"/>
        <property type="gene ID" value="B456_003G131200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788817"/>
    <dbReference type="eggNOG" id="ENOG502QRPU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HAVINQM"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000341">
        <property type="entry name" value="very-long-chain 3-oxoacyl-CoA reductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB20065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="320" mass="35940" checksum="7B7607D38442A95A" modified="2015-04-29" version="1">MEACFFDTLKAQPFWVIFLFTLGSLSLLKFSFVFLKWVWINFLRPGKNLKKYGSWGLVTGPTDGIGKGFAFQLARKGLNLVLVGRNPDKLKDVSDSILAKYAKIQIKTVVVDFTGDLDEGVKKIKETVEGLDVGVLINNVGISYPYARYFHEVDEELLVNLIKVNVEGTTKVTQAVLPGMVKRKKGAIVNIGSGAAIVIPSDPLYAVYAATKAYIDQFSRCLYVEYKNSGIDVQCQVPLYVATKMASIKRSSFFVPSTDGYARAAMRWIGYEPRCTPYWPHSILWGLAYSLPESVVDAWRLRFCLGIRKRGQMKDSRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRF3</accession>
    <name>A0A0D2RRF3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alcohol dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G066400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRF3"/>
    <dbReference type="STRING" id="29730.A0A0D2RRF3"/>
    <dbReference type="Gramene" id="KJB34449">
        <property type="protein sequence ID" value="KJB34449"/>
        <property type="gene ID" value="B456_006G066400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEMTNEG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000067">
        <property type="entry name" value="alcohol dehydrogenase 1-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:001292">
        <property type="entry name" value="Alcohol dehydrogenase class-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF26">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="11">
        <location>
            <begin position="148"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB34449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="322" mass="34964" checksum="05AC29EEDAE7172B" modified="2015-04-29" version="1" fragment="single">GQNPLFPRILGHEARGVVESVGEGVMDVQPGDHVLPIFTGECKECPHCLSEASNMCDILRINTERGGMLHDGHTRFSKDGKPIYHFLGTSTFSEYTVVHVGQVAKINPEAPLDKVCVLSCGMSTGFGATVNVAKPKKGGSVAVFGLGAVGLAAAEGARVCEASRIIGIDLNPNRFEEAKKFGCTEFVNPKDHNKPVQEVIAEMTGGGVDCSIECTGSTQAMVSAFECVHDGWGVAVLVGVPSRDDSFKTHPIHFLNERTLRGTFFGNYKPRSDIPGVVEKYMKKELELDKFITHSVPFLDINKAFEYMLRGEGLRCMIRMDA</sequence>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_006G074100"/>
    </dbReference>
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    <dbReference type="OMA" id="YCYKKCT"/>
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        </location>
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        <location>
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            <end position="158"/>
        </location>
    </feature>
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        <location>
            <begin position="138"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34589.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="239" mass="27127" checksum="7B729DB8CE6A0EE7" modified="2015-04-29" version="1">METMNKRFSRVSLVAVLLVLIAVQVNGFFPFDYESEFAQNSLDFQNFPSNSDSDENSLFSESHVYEPQSQYFHQVNPEETSLLSQSELPHDSFQTQNFESTNLPFETQQFPFEINANHRIKSPSPSPAPSPVQVSSPAPSPVEVPSPAPSPVEAPHPPKPNPDNICKLKCSTKCLKQEIPILHNLCCRVCKLRCLYHYADLIYTCTNRCAESMPNTFKSDEKKEAAYVKYCYKKCTKNF</sequence>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
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                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_009G160500"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </feature>
    <feature type="chain" id="PRO_5002266976" evidence="1">
        <location>
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            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJB26305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0584645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB26305"/>
        <property type="gene ID" value="B456_004G238200"/>
    </dbReference>
    <dbReference type="OMA" id="KIAWLVK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB26305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0584645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="245" mass="27766" checksum="A594D71D0BCA3E9B" modified="2015-04-29" version="1">MPAKIHERNGVLVSQNSHFSYVLSITLPQPTIRIKIPKVLVKAMQRRNHGRRENDAIHKKESFRKKVGSMASSVFGKNNNSPEAASDEAMMKLKKMIESLDMESEKNGEDEYVFNDGVMVLVDEKEMVEAEEGDEGKEELAMVVEAGNERKERLRLLQTYSKKISNVGNDDSGVVCVDDNEGKGTLGMKEGNGSNDMTWSQSRRRKPKIAWLVKRITEKVVGVKSKEEEVWRKRILMGEKCKPLN</sequence>
</entry>
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    <name>A0A0D2S8G5_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Auxin-responsive protein SAUR21-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G251300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ARG7 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_005G251300"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="SAUR_fam"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Auxin_inducible"/>
        <property type="match status" value="1"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022604"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB27505.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0D2S8P2</accession>
    <name>A0A0D2S8P2_GOSRA</name>
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        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G073900</name>
        <name evidence="6" type="ORF">Gorai_018171</name>
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    <organism evidence="5 7">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0589423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S8P2"/>
    <dbReference type="STRING" id="29730.A0A0D2S8P2"/>
    <dbReference type="Gramene" id="KJB40699">
        <property type="protein sequence ID" value="KJB40699"/>
        <property type="gene ID" value="B456_007G073900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802419"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ETTWDAY"/>
    <dbReference type="OrthoDB" id="5314041at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF40">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="222"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="576"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="578"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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        </source>
    </evidence>
    <sequence length="676" mass="75086" checksum="D3D2DF3686D3C627" modified="2015-04-29" version="1">MLPTYFPLRWESTGDQWWYASPIDWAAANGHYDLVRELLRIDGNHLIKLTSLRRIRRLETVWDDEEQFDDVAKCRSEVARKLFIKCESKKTKNSLIRCGYGGWLMYTAASAGDLGFIQELLQRNPLLVFGEGEYGVTDILYAAARGKNSEVFTLIYNFAVSPRFMTANAEGFKEHIGEIPSVYKWEITNKAVHAAARGGNLKILMELLHGYYKDVLAYRDKRGSTVLHAAAGRGQVEVVEKLVSSFDIIASVDDQGNTALHIAAYRGQAAVVEALIHVSPSLISVRNNAGETFLHFAVSGFQTPTFRRVDLQINLMKRLVHEKKFNMEDIVNAKNNDGRTALHLAIIGNVHTDLVQLLMSAPSINVNTSDANGMTPLDLLRRRPHSASSDMLIRHLISAGGMFGCKDHTARRAIASHLKMQHGSSPGTSFRISDTEIFLHTGVETTWDAYDANDPSSRGRSRSSSIDYDSGDENRKSSVNIKPSSKNKAAQRLKSVLRWPHMKGKKPKRLKKSIEGCSEETPIPLRQRFSKPSSSLPNNKRTLSVRSNQSSPIAKKKLASGIMKGVMQDMPQLTIQGRSRSSSFSRSSLSSPSSLDKQKGIFTEDIGGPSCYIPSTDDEKPSTIEKQGSNKKGLKRQYFCFGGSGLTMKTTVSRQRPNLNLNLNQTTVNPAMASMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAZ4</accession>
    <name>A0A0D2SAZ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ALA-interacting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_009G303800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAZ4"/>
    <dbReference type="STRING" id="29730.A0A0D2SAZ4"/>
    <dbReference type="Gramene" id="KJB60400">
        <property type="protein sequence ID" value="KJB60400"/>
        <property type="gene ID" value="B456_009G303800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60401">
        <property type="protein sequence ID" value="KJB60401"/>
        <property type="gene ID" value="B456_009G303800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60403">
        <property type="protein sequence ID" value="KJB60403"/>
        <property type="gene ID" value="B456_009G303800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770701"/>
    <dbReference type="eggNOG" id="KOG2952">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWNNDQP"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB60403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="349" mass="39298" checksum="11EC09CBA322FA94" modified="2015-04-29" version="1">MSSSTPSSSAGGVGSADSAAPRRNSKRPKYSKFTQQELPACKPILTPRWVISAFMLVSIVFIPIGVVSLFASRDVVEIIDRYETACVPDGYKNDKVTFIQSNLTKQCNRTLTVKKRMKKPIYVYYQLDNFYQNHRRYVKSRSDSQLKENSSWDDVSSCKPEDTSNGQPIVPCGLIAWSLFNDTYNFSLNDQQLAVNKKGISWKSDRDSKFGKDVFPKNFQNGTLKGGATLNPSIPLSEQEDLIVWMRTAALPTFRKLYGKIEQDLQPNDQIHVTLDNNYNTYSFNGKKKLVLSTTSWLGGKNDFLGIAYLTVGGLCFFLALSFTVVYLVKPRRLGDPSYLSWNRNPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBL9</accession>
    <name>A0A0D2SBL9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G060600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBL9"/>
    <dbReference type="STRING" id="29730.A0A0D2SBL9"/>
    <dbReference type="Gramene" id="KJB28650">
        <property type="protein sequence ID" value="KJB28650"/>
        <property type="gene ID" value="B456_005G060600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB28651">
        <property type="protein sequence ID" value="KJB28651"/>
        <property type="gene ID" value="B456_005G060600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796837"/>
    <dbReference type="eggNOG" id="KOG4441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CACKQAH"/>
    <dbReference type="OrthoDB" id="6359943at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="73"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MATH" evidence="4">
        <location>
            <begin position="712"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB28650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="93778" checksum="24C6659505CDEB42" modified="2015-04-29" version="1">MEPQFSKHRSYGQPTHHHHHQPQLKMSIPPPPPPPPQHSENDRSCSELRAFDCNLNSLCEHIRMEGFNGGSFSDIVVNAMGSTYHLHRLILSRSSYFRNMLHGPWKEANSPVVTLNVDDSNVNGEAIAVALAYLYGHHPKLNDNNAFRVLAAASFLDLQDLCAICTDFIISELWTSNFLAYQVFAENQDYGVHGERVRSACWGYLCQSGAMELKEVLPKLSSQTLHALLTSDELWVSSEEKRFELALYTLLAKDAFYQPERSGQGSSSSSEIDVGTSLESSKGKGKNLVDSFHGCVVDIPAGISSADQQVQRPKYARSESLCPCSMDQSSSMSSSFSEGIRTSHSYVEMPIGDGTSGGMAMEGPSEEGSCYQLNNNNWLASDQSKHCSSEDSSCSGLMLNDWGRCSMASLSWGGRVVGKRQVKSYAKGNCGVGGEEYDAFVNIFEGGSLLYCNMSFEALLNVRKQLEELGFPCKALNDGLWLQMLLRQRVQEIGADTCKNCCLTSMQCSCRQPFGIQHGVATTGYYVQEHDQSHLTGNIRNVYVADNAQDEGNGLFRPVRVQVRGAIDGLAGIGRGATSVPATLWTPTRFVFSRVPFGMGNRIGQQSPANEDSEARADHNGDMSGGGLTALVELSQGGTSNAINVREEQTERSCELDPQSKVPMTSIARPATSGIAMQMLETPDRAIGIDWENATSSSISLDLKTPLSHFPSFRFGVQFEDVHRLSDGQVKHSPEFFYAGSLWKVSVQAFNDEDPQGRRTLGLFLHRRKAEITDSLGKVHMFIDSREKVTARYQLICPSKRDVMVFGSFKQRGTLLPKAPKGWGWRTALLFDELADLLQNGALRVAAVVQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBQ7</accession>
    <name>A0A0D2SBQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Membrane-associated kinase regulator 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G316400</name>
        <name evidence="3" type="ORF">Gorai_013123</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0596297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="entry name" value="BKI1/MAKR1/3/4"/>
    </dbReference>
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        <property type="entry name" value="MEMBRANE-ASSOCIATED KINASE REGULATOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33312:SF5">
        <property type="entry name" value="MEMBRANE-ASSOCIATED KINASE REGULATOR 4-RELATED"/>
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            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0596297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="303" mass="33491" checksum="5D3C2462444CB66B" modified="2015-04-29" version="1">MAVSHLSNDLEDDEYIEMEVSSYSTFFCNSSSISSPPPQFPIPIEFEFQMSSSMEIQPTTSPADELFYKGKLLPLHLPPRLQMVQKLLQNSTSLYGDFYGTPLTSTPFESCNVSPSQSCRISQELNPEECLFEYSTEALSGHCNDKNHRKKSSSSVIGSKLKAYRGYLKSLFSKSGCSSESCSAAKVADEGSILRAKERLDRSMMMKSTKKAPFGQIRHRRSLSLAIKRQDSTNKSPSSSSSSGSSPSPNSNGVQYLQLLKRSSSVNVEIESPIQGAIAHCKQSQQLIRSRKTVSEVGHAIWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQH8</accession>
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            <taxon>malvids</taxon>
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    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0586994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQH8"/>
    <dbReference type="Gramene" id="KJB33470">
        <property type="protein sequence ID" value="KJB33470"/>
        <property type="gene ID" value="B456_006G012200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVZ6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CEHEVSK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012417">
        <property type="entry name" value="CaM-bd_dom_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33349">
        <property type="entry name" value="EMB|CAB62594.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33349:SF41">
        <property type="entry name" value="EMB|CAB62594.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07839">
        <property type="entry name" value="CaM_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CaM_binding"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calmodulin-binding" evidence="2">
        <location>
            <begin position="296"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="196"/>
        </location>
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        <location>
            <begin position="328"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="116"/>
        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0586994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="429" mass="47439" checksum="CA31F1AD67E602F4" modified="2015-04-29" version="1">MAAESVGSSMTPEIPGINGGDSRRSSLSCAANNKERTRSLYRRASTGCCHDICKPEKKHESEEKAPKLPFPKRITKKAFDEPNLFENLELPPKKKIVKPETSTNSPSGSSSGVKKVVPMKEKASMEKVKAKYPPNSRRHSIDITDVVNFEDKKTSMTKLKSSPKLKPDVFDAGKVVKQDRSLPSKKVPSKANERSCYKRSITCLKPKNQAERKSGIDDMKTGKRNVIKELAASQKASTAGATSLTTRKYRNLKVVPKQKDRNKVENGETEQLLDEHDTLQEKTLYVIKLETENMMLESDKNENCAAELSPPIVDESGYAVTKVDHDSVPEYGEDKTVNTEAADNSSNNGPLRLKSGQGRETDGDTNDIVSRHKSVQGKIDGKSLFNNVIKETVNKLVETRKNKVMTIVGAFETAISLQDSKPLSNVASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSL3</accession>
    <name>A0A0D2SSL3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G058200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSL3"/>
    <dbReference type="Gramene" id="KJB34300">
        <property type="protein sequence ID" value="KJB34300"/>
        <property type="gene ID" value="B456_006G058200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB34300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="76" mass="8794" checksum="C38BD2562572ED19" modified="2015-04-29" version="1">MRLNFIILFVYLFLIIILIIFQKRELVFENPKQKEEIEVILATASAPPPAMKFNIANLTTGCQKKLEIDDDQKLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSP7</accession>
    <name>A0A0D2SSP7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G286900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSP7"/>
    <dbReference type="STRING" id="29730.A0A0D2SSP7"/>
    <dbReference type="Gramene" id="KJB45041">
        <property type="protein sequence ID" value="KJB45041"/>
        <property type="gene ID" value="B456_007G286900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804739"/>
    <dbReference type="eggNOG" id="KOG0308">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REEMCAS"/>
    <dbReference type="OrthoDB" id="2421129at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:003673">
        <property type="entry name" value="Transducin/WD40 repeat-like superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001545">
        <property type="entry name" value="WD repeat-containing protein 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="122"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="256"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB45041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="763" mass="83539" checksum="E6E5515EE83FD42F" modified="2015-04-29" version="1">MHRVGSAGNNTNSNRPRKEKRLTYVLNDTADTKHCAGINCLAVLKSSASDGCDYLFTGSRDGTLKRWALGENAATCSATFESHVDWVNDTVIAGDSTLVSCSSDTTLKTWNCLSEGTCTRTFRQHSDYVTCLAAAEKNTNVVASGGLGGEVFVWDIEAAATPVSKSSDVVEDDCSNSMNGSANLLPISSPRTISSSNSIRTHATQCHGYVPIAVKGHKESVYALAMNGSGSLLVSGGTEKVVRVWDPRTGSKNMKLRGHADNIRALLLDSTGRYCLSGSSDSMIRLWDLGQQRCVHSYAVHTDSVWALASTPTFSHVYSGGRDLSLYLTDLTTRESLLLCTKEQPILQLALHDDSIWVATTDSSVCRWPAEGRTPQNVFQRGGSFLAGNLSFSRARVSLEGSTPAPVYKEPIFTIPGTPAIVQHEILNNRRHVLTKDAAGSVKLWEITRGVVIEDYGQVSFDKKKEQLFEMVSIPAWFTADTRLGCLSVHLDTPQCFTAEMYSVDLNITGKPEDDKVNLARETLKGLLVHWLAKRRQRHGTQASANGDVVSGKDMTARSSAHSRIEVDGNAENDSLVYPPFEFSTVSPPSIITEGSQGGPWRKKITELDATEDEKDFPLWVLDCVLNNRLPPREKTKCSFYLHPCEGSAVRILTQGKLSAPRILRMHKVVNYVIEKLVLDKPIDSLNIDGTYAAGLGGQPQHSAGGEGSLRSGLKPWQKLRPSIEILCNNQVLSPEMSLATVRAYIWKRPEDLVLNYRMIQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SSW5</accession>
    <name>A0A0D2SSW5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G292400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SSW5"/>
    <dbReference type="Gramene" id="KJB45146">
        <property type="protein sequence ID" value="KJB45146"/>
        <property type="gene ID" value="B456_007G292400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF56">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="48"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB45146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="413" mass="44765" checksum="034359CFD9B9B1E5" modified="2015-04-29" version="1">MGRQRTEATESLLVRQGNDNLVYNEENGGLGDGGSEAVSDVTTILGLSTFVATCIAFGSGCAVGYSSPTESSIMEDLGLSVAEFSVFGSILSIGALLGSAISGKITDFLGRKLTMWILNLFYIGGWLAIAFAKTPWLLDLGRLSLGFTVGTFTYLMPVYISEITTKNVRGRFSVIPSLTVGWGISFMYIVGSFVSWRTLALIATIPGLLQLLPLFFIPESPRWLAKVGRDKELEDVLLCLRGNKADIFNEAAEIKDYVESLKSFSKEGILEIFQKKYFRPLLTLIGMIILMNLGGANAFSFYSGVIFVSAGLSSMVGLITLATTQTIVGVLGIILIDKLGRRPLQLVSTAGLCFSCFLTGLSFLLKESNWWDQGSPALAFIGLLVYTGSYIVGSGIPWLLLSEVHKLFSFMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUY6</accession>
    <name>A0A0D2SUY6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G101200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUY6"/>
    <dbReference type="STRING" id="29730.A0A0D2SUY6"/>
    <dbReference type="Gramene" id="KJB35120">
        <property type="protein sequence ID" value="KJB35120"/>
        <property type="gene ID" value="B456_006G101200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2870">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FSSIMVW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="5">
        <location>
            <begin position="92"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB35120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="200" mass="23879" checksum="5D152935776503EE" modified="2015-04-29" version="1" fragment="single">MIVNMGPHHLSMHGVFRLIVTLDAEYIVDCELILSYLHREMEKIAKNRTIISYLSYSNYVGVESYSFSSIMVWIIFYIFKERELVNDLFEAIIERIEGMGIIGGEEAINWGLPDPMLRASEIKLDLRNFDHYECYDKFDWEIQWQKERDSLARYLARISEMTESIKMIQQALERIPKSPYENLEIRCFDRERDPEKKFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVR9</accession>
    <name>A0A0D2SVR9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G351100</name>
        <name evidence="4" type="ORF">Gorai_020053</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
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                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <location>
            <begin position="75"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF05678"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB46156.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0591375.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
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    </evidence>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Mansoor S."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Protein modification; protein ubiquitination.</text>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXE2"/>
    <dbReference type="Gramene" id="KJB46776">
        <property type="protein sequence ID" value="KJB46776"/>
        <property type="gene ID" value="B456_008G100700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763655"/>
    <dbReference type="eggNOG" id="KOG0768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000095">
        <property type="term" value="F:S-adenosyl-L-methionine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000038">
        <property type="entry name" value="S-adenosylmethionine carrier 1 chloroplastic/mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="11 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="132"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="227"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB46776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34764" checksum="2F177D0F77E6EA3F" modified="2015-04-29" version="1">MGPFTLAVDTKSSSLVSSDVSNRKIKNLQLQTKKCFASVSMEEEKPFDFLRILFEGIIAGGTAGVVVETALYPIDTIKTRLQAARGGGKIVLKGLYSGLAGNLAGVLPASALFVGVYEPTKQKLLKLFPENLSAVAHLTAGAIGGIAASLIRVPTEVVKQRMQTGQFTSASNAVHVIASKEGFKGLYAGYGSFLLRDLPFDAIQFCIYEQIRIGYKAAARRDLNDPENAIIGAFAGALTGAITTPLDVIKTRLMVQGSANQYKGIFDCVQTILREEGPSALLKGIQPRVLWIGIGGSIFFGVLESTKRLLAERRSKPTQQSKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SYV9</accession>
    <name>A0A0D2SYV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">B456_010G253800</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="19"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SYV9"/>
    <dbReference type="Gramene" id="KJB68598">
        <property type="protein sequence ID" value="KJB68598"/>
        <property type="gene ID" value="B456_010G253800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772407"/>
    <dbReference type="eggNOG" id="ENOG502QSUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQWNAGN"/>
    <dbReference type="OrthoDB" id="1910371at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000060">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000005">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000330">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase At4g03230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF932">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PAN_AP"/>
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        <property type="entry name" value="S_TKc"/>
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        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
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        <property type="entry name" value="EGF_3"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 20" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
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    <keyword evidence="8" id="KW-0430">Lectin</keyword>
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    <keyword evidence="6 22" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
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    <feature type="chain" id="PRO_5002251330" description="Receptor-like serine/threonine-protein kinase" evidence="23">
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            <begin position="28"/>
            <end position="838"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="26">
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            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="25">
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            <begin position="288"/>
            <end position="325"/>
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    <feature type="domain" description="Apple" evidence="27">
        <location>
            <begin position="344"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="523"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="551"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    </evidence>
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        <source>
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    <sequence length="838" mass="94367" checksum="797ADAB7307E8187" modified="2015-04-29" version="1">METKNKTPFFVSSLIFLLCCLARFCYGTDIIRQGKTMKDGDKLVSSDGVFELGFFSPENSRFRYVGIWYKVDMEAVVWVANRDKPMVNTNGVLRIGIDGNLVVLDGDRNFVWSSGVPGILSNTSSARLQKNGNLELLNNDTSEVIWESFHHPTDTFLPGMKLPVSISMGEVRFFTSWRSAIDPSCGNYSAGIIPNGGPQIVIWDQSGRRRWRSGQWNAVIFTGVSNMSNTASFLYGFKLSEPDENGTRYFTYNPSNSSALSRFRIGYDGTERHLRWDGKKWTVLLSQPGTKCDLYNHCGNYATCDNFVSSSTCNCLEGFRPKFEDQWSKGNWSGGCERRTELECQRGKPDGFKRMKCMKLPDFSNILVPVKSRDDCRQSCLGNCSCTAYAYVYGIGCMIWVGDLVDVQHIDQSGTIQFFYRLNHSDLDDKKKISNGVIVIISMVGACFLVAFLWLLWRYKKKLKVSSMVCCKDKDAVVFNEFSTEFSADFSGPSDILIDGNQVNRPELPIFNFSTVAAATNNFCEENKLGQGGFGAVYKGELPGGQEIAVKRLSRQSGQGLEEFKNEIILLAKLQHRNLVRLLGCCIQGEEKMLIYEYMPNKSLDNFLFAKQAVLDWRTRVGIIEGIARGLLYLHRDSRLRIIHRDLKASNILLDAEMNPKISDFGMARIFGGNQIEANTVRVVGTYGYMSPEYAMEGLFSIKSDVYSIGVLLLEIVSGRRNTSFRSSEYTSLIAYAWQLWEDDKAMYIVDPLIQESCCPKEALKCIHIGMLCVQDSAMYRPTMATVVLMLESEAPTLPKARQPTYRSFRRSIDEQPIPNGQEIVSSNDVTITTIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZ97</accession>
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    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="12">8</strain>
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        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0588053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_006G167600"/>
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        <property type="component" value="Chromosome 6"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="protein indeterminate-domain 12-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="protein indeterminate-domain 5, chloroplastic-like"/>
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        <property type="entry name" value="C2CH-4th_BIRD-IDD"/>
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        <property type="entry name" value="C2H2-2nd_BIRD-IDD"/>
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    <dbReference type="InterPro" id="IPR031140">
        <property type="entry name" value="IDD1-16"/>
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        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00096">
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    </dbReference>
    <dbReference type="SMART" id="SM00355">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
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        <location>
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        </location>
    </feature>
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            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB36625.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0588053.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="452" mass="48935" checksum="0C58A4408B3E1060" modified="2015-04-29" version="1">MSGEAFSLPAASIGGFIQDPSNANPNPKPNANPAKKKRNLPGTPDPDAEVIALSPKTLMATNRFICEICKKGFQRDQNLQLHRRGHNLPWKLRQRTNKEVRKKVYICPEKTCVHHDPSRALGDLTGIKKHFSRKHGEKKWKCEKCSKKYAVQSDWKAHSKTCGTREYKCDCGTLFSRKDSFITHRAFCDALAEESARLTSVAATSLNFRNDTVNLPHGFAGRGVQDVAGIPQFGSGFPQDFSGMPAPGLPEMVQMAPANVFGSSSHFPGFENGGATSSNSNNLSLSQLPQGLKEEGRNEGNLMESLSSLYSDNQNKQSKANASPMSATALLQKAAQMGSTRSNSSFFGNSFGVMSSSSSHTAPTFMASSSASMSATSNKLDKLMLQTGGKPSEPTLLSMHHPGSNSFAQSLTRDFLGMSNDQSPRPFLPQELAKYAAIGSTMGLSQFTSSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZR6</accession>
    <name>A0A0D2SZR6_GOSRA</name>
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        <submittedName>
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        <name evidence="2" type="ORF">B456_006G177700</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <begin position="55"/>
            <end position="92"/>
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    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB36815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="151" mass="17043" checksum="91AE9136E0572544" modified="2015-04-29" version="1">MLHQRPPWVREEPATRGKRLRPSHRPSATKGTMLVQQCSISLALQTREAKVVVVPPKKTGEANRTKPNVANRRGGGASKAIGEKPLIFGQRPTKERGERFGHYCVRKARKGRQTTAGTRPIMAEERKVVCRICSDLNLIYYKISSKRHSFN</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_008G076000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763364"/>
    <dbReference type="eggNOG" id="ENOG502QWDH">
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    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32011">
        <property type="entry name" value="OS08G0472400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32011:SF2">
        <property type="entry name" value="OS08G0472400 PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
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            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB48581.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T3Z2</accession>
    <name>A0A0D2T3Z2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G072700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T3Z2"/>
    <dbReference type="STRING" id="29730.A0A0D2T3Z2"/>
    <dbReference type="Gramene" id="KJB70423">
        <property type="protein sequence ID" value="KJB70423"/>
        <property type="gene ID" value="B456_011G072700"/>
    </dbReference>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="2274" mass="241076" checksum="D37401F44F49ACF2" modified="2015-04-29" version="1">MALFRRLFYRKPPDRLLEISEHVYVFDCCFTADVLEEDEFKVYMGSIVAQLQDYFPDASFMVFNFREGDRRSRISDILSEYDMTVMDYPRQYEGCPLLPLEMIHHFLRSSDSWLSLEGQQNVLLMHCERGGWPVLAFMLASLLLYRKQYSGEQKTLEMVYKQAPRDLLKLLSPLNPRPSHLRYLQYISRRNLSSDWPPAHTPRDLDCIILRVLPLFEGGEGCRPVIHVYGMDPKTPANRSSKLLFSTSKTKKQVPYFRKEECALVTIDTHCHIQGDVVLECVHLYDDLVHEETIFRVMFHTAFVRRNILIFNHDDVDVLWDARHQFPKDFTVEVVFMDRDAVVPNLPRVATKSEDRNDGECASPEEFFEVEEIFSNAVDAVEGKVDVLDGKVDALDGKVDYDSQIVHENKPEQKDILREDVDSHLLDGKVDYNSQIVHENKPEQKDISREDVDPHALDGKVDYDSQIVHENKPEQKDILREDVDPHRIQECSTYDGNKKQDVKFDSSIDAVKDIAMDDVNYKLHMKLDSDINAVKDIAVDDGDIKAGSVEFTINLLRERETKEVTEDVLGKLEDTADTGNREESVPLKKQRLKTDVSRSKPEKILPISKKQDGLSPKPASDSALVKPKSRQLEPQGQPARPAKPNAVSRWIPPNKGSYANSMHVSYPPSRPNSAPPVPSSTLRKSKSVSNLKGSIGAVISKDVSSKQKCQKVDDTKTSKDFSSEQKGQKVDLTKPSGSPKEIYTAPIIPTPLPGLQQSVYIPPSTPAAAPPPAPPSPPPPRSLLASQSLEENTISILPPPLSGNVSRMSFAALSTPPPPPPPPPCTAIKVHTTGMLSQNPVAVPPPLPPSPPFSNPQISKLFSSRPPPSPPLKSRFSSAFLNVLHSQAPPRPSPVRSLGTSKLGNVPSFHQKPPPTPPTQGAMAPSIMHEVLSAPSPPLAPPLCDAPSSPPLPPLVPTRHVPLPPPPPPPPPQYRALAPLSQPMPHYIASTPPIPLPPPLLLGMCASSSLPSPMPHSPSPPLELPPLMSTTPSPPPPPLTSAPTPPPLPPSMSTTSIPPSPPLLICSATIPPPPPSQPPLMSSALPPPPSAPLLMSNASLPPTPPSPPSISSCPPPPALPLPSMSSVLLPPLAPLPPLMSSVPPPPPPPPTPSPLSVYGTPLPSSPLAPSMSSDPPPQLPSMSNALLPPPSPPSLTTIAPLPFLPSPSFSMTSVPPPPPSSLPPQLTSSAPIPSPPSPSSSTTSVPLPPPPSPPFSATIAPHPPPPSPPSSTTTVPLPLTSPPFSTTIASSPPSPPPPPMCSTPLPPFSPPFSTTIASSPPSPPPPPMCSTPLPPPSPPSLTNIVPSPPAPQLPSMSSASLPPPSPPSSVTSALPPSIPPPSPPPLLMSTASFPAPPSPPFLTTSAPPPPSPPPPSISNTPLPPPSVSSAPLPLSLSPTTLMTSAPPPSPSLPSPPPTLMSTAPLPPPSSPPSATTSAPPLLSPSPLSISSIQPLPSSMSSASIPRSPSPTTLTTSALPPPSPPPSSISSTPPPPSPTTSMTSTPAPPSPPPPSISSTPPPPPSMSSASIPPSPSPNTLMTSALLPPPPPSPPPPSISSTPPPPSPTTLTTSAPPPPSPPPPSTSNTQPPPPSISSASLPPSPLSTTFSTSASPPSPPPQLVSSVPPSSPPSMSSVSPPPPPPPSSMFDVPHPPLPPLPGVPPPPPTPFGAPLPPPPPVNEIVAPAPLMHGAPPPPPLPPTIGEPPPPPPSGVPPPPPPPLGIEPPLPAPPFGVGPPPPPPPPGGGAPPPPPPPGGGAPPPPPPPGGGAPPPPPPPGGGAPPPPPPPGGGAPGPPAPPGAVGGGPPPPPPFGAKGADARGRGRGLSRSGAIQTARRSSLKPLHWSKVSRAIQGSLWEELQRHGEPQVAPEFDVSELETLFSNVVPKRSGDKGKGKSAGPKTDKVHLIDLRRANNTEIMLTKVKMPLPDMMAAVLAMDDTVLDVDQVENLIKFCPTKEEMELLKNYTGDKESLGKCEQYFLELMKVPRVESKLRVFCFKIQFRTQVSEFKRSLNIVNSACNEVRNSLKLKDLMKKILYLGNTLNQGTARGAAVGFKLDSLLKLTDTRASTSRMTLMHYLCKVLAAKKPALLDFHLDFVSLEAATKIQLKALAEEMQAIIKGLEKVKQELAASENDGPVSEVFHKTLKEFVSGAEAEAASVTNLYSTTGRNADALALYFGEDPARCPFEQVTSTLLNFVRLFRKAHEENVKEAEAEQKKAEKEAETEKSKGKQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB26</accession>
    <name>A0A0D2TB26_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G079400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TB26"/>
    <dbReference type="Gramene" id="KJB40835">
        <property type="protein sequence ID" value="KJB40835"/>
        <property type="gene ID" value="B456_007G079400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SG53">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVAMMET"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37908:SF4">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37908">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251942" evidence="2">
        <location>
            <begin position="22"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB40835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9434" checksum="60615961512251EC" modified="2015-04-29" version="1">MGGSWFLKLLLLSMLFILSFSQGLGRKWMENNVEFQDYSVQLEEFAEKAREMMEIMDYKEPGPNTNPRTSYIFGPPPQPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TBY3</accession>
    <name>A0A0D2TBY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G223900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TBY3"/>
    <dbReference type="Gramene" id="KJB73238">
        <property type="protein sequence ID" value="KJB73238"/>
        <property type="gene ID" value="B456_011G223900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000604">
        <property type="entry name" value="Proline-rich receptor-like protein kinase PERK8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000849">
        <property type="entry name" value="receptor-like cytosolic serine/threonine-protein kinase RBK1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989:SF8">
        <property type="entry name" value="INACTIVE PROTEIN KINASE SELMODRAFT_444075-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47989">
        <property type="entry name" value="OS01G0750732 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="334"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="188"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="661"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB73238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="691" mass="77544" checksum="1756920BD588A6D4" modified="2015-04-29" version="1">MTKEAERVVVILDGSKELNPSIIKWPLFGLSLKPGDKLLVLGILHQVINPMGFKSKVDTSSIFGTNRRITVEEMGKKLEQYNKDAALVKISEQYKKEQIEFQVKILAGYPLKDVAARAVKSFGATWLVLDRHMKNDQRYFVENLSCNIVRLKKDCNAEELRGPNVKDNFKLPQCHIPYAEMIPAIGPQRLHSPQNREGESIGEHQSHSNRKSISRSSSASSISGNRAPFLSYNEPKSSSSSMYVHDEAYGTTTGPETGGEHSPLSINESGDQKDLQSPDENPKQHNHNDDWMGGNPGDQVFKNSLCLICKNRRPKIGWMRDFTYAELQAATEGFNAKNFLSEGGFGSVYRGEINGMKIAVKQHKYNASLQGEKEFKSEVHVLRTARHENLVMLVGSCSEGNHRLLVYEYVCNRSLDLHLSKHSRRPLSWQKRVKIALGTAKGLKYLHDNNIIHRDMRPNNILVTHEFEPLLGDFGLARTQHEDSDKSSETMTRVVGTLGYLAPEYAECGKVSTKTDVYSFGVVLLQLITGMKTTDKRLGGKSLVGWARPLLKDRNYPDLIDQRILDKHDVHQLFWMVRVAEKCLTKDPQKRLSMDKVVFALNYITDCDNFCGIEDFSPAQSDTVSQDSYDSVSQSPFEDDSVFTIETTSANSLSLFNERLPPSPPISSKSSASTLFGESASSSGSNHERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TCG3</accession>
    <name>A0A0D2TCG3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_011G232600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TCG3"/>
    <dbReference type="STRING" id="29730.A0A0D2TCG3"/>
    <dbReference type="Gramene" id="KJB73423">
        <property type="protein sequence ID" value="KJB73423"/>
        <property type="gene ID" value="B456_011G232600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777590"/>
    <dbReference type="eggNOG" id="KOG0156">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IVENHDI"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11072">
        <property type="entry name" value="CYP71-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000011">
        <property type="entry name" value="Cytochrome P450 83B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955:SF15">
        <property type="entry name" value="CYTOCHROME P450 71A2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47955">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 71 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB73423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="57874" checksum="17DFC46E40F62B23" modified="2015-04-29" version="1">MELLNVAKLSFNLLFSSLILLLSLLIWLKLAKRKTLNLPPSPPKLPLIGNIHQLGKLPHRSLRDLSRKYGSLLLLQLGYNPTVVVSSADIVREIVENHDIVFANRPRTTAVDILFYGSKDMAFAPNNKFWKQVRKISVVELFSHQRVHSFQFVRDEEVELLTNKIRSACLKGESINLTDMLMFVSSNIVSRCFLSHKNEEEDGCTKFGELAKRLLILFTSSCIGDMFPYLRWVDVLTGYIPSMKAVSAELDAFLDQVIQEHKAFESNDQVSNKKDFVSIIMQLQKDGMYEMDLTQDNIKAILLDMFVGGTDTSATTKEWMMAELLKHPNAMKKVQEEVRNVVGNKLRVDAEDVSKMEYLKCVLKETLRLHPAGPLMVPRETTASVKLGGYDIPSNTTVLVNVWAIQRDPKWWENPEEFIPERFENSSIDFKGQDFQFIPFGFGRRRCPGMPFGVAAIEYVMANLLYWFDWKLPAGEIAENLDMTELFGLTVTKKTPLHVLPLSHFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TDV0</accession>
    <name>A0A0D2TDV0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G050000</name>
        <name evidence="5" type="ORF">Gorai_011135</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TDV0"/>
    <dbReference type="STRING" id="29730.A0A0D2TDV0"/>
    <dbReference type="Gramene" id="KJB54809">
        <property type="protein sequence ID" value="KJB54809"/>
        <property type="gene ID" value="B456_009G050000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770586"/>
    <dbReference type="eggNOG" id="ENOG502QTAB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHERPHQ"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044552">
        <property type="entry name" value="GLIP1-5/GLL25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966">
        <property type="entry name" value="GDSL-LIKE LIPASE/ACYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45966:SF36">
        <property type="entry name" value="INACTIVE GDSL ESTERASE_LIPASE-LIKE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="25"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB54809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0594223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="361" mass="40266" checksum="95BAEAC6E88D6DD1" modified="2015-04-29" version="1">MANLRASCISFLLCFTTCINLISSHYLPENHVALFIFGDSLFDPGNNNYINTTADFRANFYPYGETFFKCPTGRFSDGRLIPDFIAQFAGLPIIPTYLQPGKRKFTDGVNFASGGAGALVESHQGFVVDLETQIKYFNKVEKSLRQELGDAGAKKLMSKAVYLISIGGNDYFTKNSSVSDEEFVSMVLGNLTVALKEIYKKGGRKFGFPNLLPLGCLPYMKAQSGGSCIDELTAIAKLHSAELLKTLVKLQNQLEGFKYAYYNLYQSFTERLNNPSKYGFKDATTACCGSGPYGGVYSCGGKRGIEVYELCDKPGDYFFFDSYHPSEKAYRQLAELMWAGNTDIVWPYNLKMLFQDNAFYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TDZ8</accession>
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        <recommendedName>
            <fullName evidence="13">Signal peptide peptidase-like 1</fullName>
        </recommendedName>
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        <name evidence="10" type="ORF">Gorai_010595</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB52781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TDZ8"/>
    <dbReference type="STRING" id="29730.A0A0D2TDZ8"/>
    <dbReference type="Gramene" id="KJB52781">
        <property type="protein sequence ID" value="KJB52781"/>
        <property type="gene ID" value="B456_008G276400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB52782">
        <property type="protein sequence ID" value="KJB52782"/>
        <property type="gene ID" value="B456_008G276400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765529"/>
    <dbReference type="eggNOG" id="KOG2443">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VDYQWAY"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030660">
        <property type="term" value="C:Golgi-associated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF22">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB52781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0593660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40734" checksum="98803E23B34E929B" modified="2015-04-29" version="1">MDSLWKLLYLLEPAPLTLILTAVAVTFGSAFRALNYGKEMERNRDLSEASITLDRSQALMIPIMSSCSLLLMFYLFSSVSQLLTAFTAIASVSSLFFCLSPHVAYLKSQLGLADPFVSRCCSKSFTRIQGLLLLACILMVAAWLVSGHWILNNLLGISICIAFVSHVRLPNIKICAMLLVCLFVYDIFWVFFSERFFGANVMVSVATQQASNPVHTVANSLSLPGLQLITKKLELPVKIVFPRNLLGGASPGGNSADFMMLGLGDMAIPAMLLALVLCFDHRKTRETVSLLDLHSSKGHKYIWYALPGYAVGLVTALAAGILTHSPQPALLYLVPSTLGPVIFISWLRKDLVELWEGTMPNLSDKARQIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TH64</accession>
    <name>A0A0D2TH64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G180500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TH64"/>
    <dbReference type="SMR" id="A0A0D2TH64"/>
    <dbReference type="STRING" id="29730.A0A0D2TH64"/>
    <dbReference type="Gramene" id="KJB43030">
        <property type="protein sequence ID" value="KJB43030"/>
        <property type="gene ID" value="B456_007G180500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803571"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFVWGTG"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Jones D.C."/>
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                <person name="Mansoor S."/>
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                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>A0A0D2TT85</accession>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Reddy U.K."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35286:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    </dbReference>
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        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB46575.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A0D2TU86</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="3" type="ORF">Gorai_008561</name>
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    <organism evidence="2 4">
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
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                <person name="Frelichowski J.E."/>
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                <person name="Peterson D.G."/>
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                <person name="Scheffler B.E."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="8">Belongs to the HSF family. Class A subfamily.</text>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U6F9"/>
    <dbReference type="STRING" id="29730.A0A0D2U6F9"/>
    <dbReference type="Gramene" id="KJB63486">
        <property type="protein sequence ID" value="KJB63486"/>
        <property type="gene ID" value="B456_010G003600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:128031859"/>
    <dbReference type="eggNOG" id="ENOG502QQ3M">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYVAMAN"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000010">
        <property type="entry name" value="glucan endo-1,3-beta-glucosidase, basic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265434" description="glucan endo-1,3-beta-D-glucosidase" evidence="8">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB63486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="343" mass="37720" checksum="15EBC12BC2A3E42D" modified="2015-04-29" version="1">MANAIMHSTMLLLLSGLLLAIFKTTGAEVGVCYGMRANNLPPAAEVIDLFKQKGIKRMRLYDPNPDALQALGGTNIELLLDLPSANLESVAASQANADQWVEDNIKKYNTVNFRYIAVGNEVKPTDSFAQSLFPAMQNIRTAIVNAGLGDQIKVSTATFFDAIDKSSFFPPSKGSLDPEYQKLLGQVITFLRDNQAPLLVNTYPYFSHIGDPEHVPLDYALFTAPSAVVQDGSLQYQYLFDAMLDTFYSALEKAGGGSLDIVVSETGWPSDGGQATSVDNAMTYNTKLVQHVNQGKGTPKKPEKAIVAYLFAMFDENEKEPAFEKHWGLFFPNKQEKYSISFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9D1</accession>
    <name>A0A0D2U9D1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_N025200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204686">
        <property type="protein sequence ID" value="KJB84433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9D1"/>
    <dbReference type="STRING" id="29730.A0A0D2U9D1"/>
    <dbReference type="Gramene" id="KJB84433">
        <property type="protein sequence ID" value="KJB84433"/>
        <property type="gene ID" value="B456_N025200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KIMIILH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB84433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="164" mass="18646" checksum="AFC5D95F50E86415" modified="2015-04-29" version="1">MKIMIILHLILESSHKLYHLVSFHQLNSFPNTCTVCGGALQNLRWRVNSGVFTVDRCNIQRTWAARFIQAAWRRYSKRKIMELHRKEEEEEEEAEGSDGYRSNSGGGSYSLGASFLASKFAANALRGIHRNQNAKSAKKLVKLQKPPEPDFAAEDADRYVTANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UA77</accession>
    <name>A0A0D2UA77_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G265000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>salicylate + NADH + O2 + H(+) = 2,3-dihydroxybenzoate + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:51792"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:30762"/>
            <dbReference type="ChEBI" id="CHEBI:36654"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UA77"/>
    <dbReference type="Gramene" id="KJB52495">
        <property type="protein sequence ID" value="KJB52495"/>
        <property type="gene ID" value="B456_008G265000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765409"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENSPHFL"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Protein DMR6-like oxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DIOX_N"/>
    </dbReference>
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        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="222"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="371" mass="42727" checksum="14FA3911D0548B96" modified="2015-04-29" version="1">MNLNEISKYCSQHSLVSTVAPLLLYFLLGIPIWDMDTKVLSSGIRYSNLPANYVRPESERPRLSEVSECEDVPVIDLGCEDRTHIIQQICHACMRYGFFQVINHGVSKETVEKMLQVAHDFFELPLEEKLKLYSDDPSKTMRLSTSFNVNKEKVHNWRDYLRLHCYPLHKYVPEWPSNPPPFKDIVSNYCVEVRELGYRLQELISQSLGLEKDYIKNVLGEQGQHMAVNYYPPCPEPELTYGLPGHTDPNALTILLQDLQVAGLQVLKDGKWLAVNPQPDAFVINIGDQLQALSNGRYKSVWHRAVVNANKERMSVASFLCPFDRALISPAKPLTEDGCEAVYRDFTYAEYYSKFWSRNLDQEHCLELFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF79</accession>
    <name>A0A0D2UF79_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G152600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF79"/>
    <dbReference type="STRING" id="29730.A0A0D2UF79"/>
    <dbReference type="Gramene" id="KJB66691">
        <property type="protein sequence ID" value="KJB66691"/>
        <property type="gene ID" value="B456_010G152600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2669">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16981">
        <property type="entry name" value="CID_RPRD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000018">
        <property type="entry name" value="ENTH/VHS family protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF23">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB66691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="203" mass="23574" checksum="88B7DD2B133434B3" modified="2015-04-29" version="1">MGSSFNPQILVEKLAKLNNSQASIETLSHWCIFHMNKAKQVVETWDRQFHCSPRKQRLAFLYLANAILQNSRRKGSEFVGEFWKVLPDALRDVIESGDEFGRNDALRLISVWEKRKVFSSRGQILKEELFGRQSECNNRNGRHINPKLLKQPVGDTVDKIVLGYQFLYCSQMDEDVIFSKCRNAISCKNIFNIVTFNIIVRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFX8</accession>
    <name>A0A0D2UFX8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G201700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFX8"/>
    <dbReference type="Gramene" id="KJB67644">
        <property type="protein sequence ID" value="KJB67644"/>
        <property type="gene ID" value="B456_010G201700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB67644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="9130" checksum="FA4848D10A2BC467" modified="2015-04-29" version="1">MLSKYLTMTPGEILLPLFSARSFTSYKVASVNGDYSFSLLLLCCLCYYWWSLPLLLPRAQLTTLHLYHCAKTYNAYCFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ91</accession>
    <name>A0A0D2UJ91_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small acidic protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G088300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
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                <person name="Grover C."/>
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                <person name="Hu G."/>
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                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Das S."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF03168"/>
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    </evidence>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
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                <person name="Scheffler J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <property type="entry name" value="Xan_ur_permease"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0595483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="60007" checksum="BEA8C3A963B68C35" modified="2015-04-29" version="1">MGETENHHHHHPPPPQAAAPPAAPPNLALSRGPTWTPAEQLHQLQYCIHSNPSWPQALLLAFQHYIVNLGTTVLIASNIVPLMGGTHGDKARVIQVLLFMSGINTLLQTLIGSRLPTVMGASIAYTLPLFSIINDYNDEDFASPHDRFVHSMRTIQGSMIVSSFLNIILGYGRAWGELTRFFSPIVVVPVVCLVGLGLFARGFPLLGNCVEIGLPMLILLMICQQYLKRIHSRAHLILERFALLLCIGIVWAFAAILTVSGAYNNVKPATKQSCRTDRSFLMSSAPWIKIPYPFQWGTPIFRASHVFGMLGAALVSSAESTGTFFAAARLSGATAPPAHVLSRSIGLQGIGMLLEGLFGSLVGTTASVENVGLLGLTHIGSRRVVQISTAFMIFFSIFGKFGAFFASIPLPIFAAIYCILLGIVAASGITFIQFANSNSMRNIYVLGVSLFLGLSIPQYFVTSRTFDGHGPVRTNAVWFNDILNTIFSSPATVAIIVGTLLDNTLEANHVEDRGIPWWKPFQHSKGDVRTEEFYSYPLRINEYLPSRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UUM1</accession>
    <name>A0A0D2UUM1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L13a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G159000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UUM1"/>
    <dbReference type="STRING" id="29730.A0A0D2UUM1"/>
    <dbReference type="Gramene" id="KJB72096">
        <property type="protein sequence ID" value="KJB72096"/>
        <property type="gene ID" value="B456_011G159000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777735"/>
    <dbReference type="eggNOG" id="KOG3204">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHHYETI"/>
    <dbReference type="OrthoDB" id="962189at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13a-4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF39">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13X-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB72096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="23628" checksum="7EB7851F73784323" modified="2015-04-29" version="1">MVSGSGICAKRVVVDARHHMLGRLASILAKELLNGQKVVVVRCEEICISGGLVRQKMKYMRFLRKRMNTKPSHGPIHFRAPAKILWRTIRGMIPHKTKRGAAALARLKTYEGIPAPYDKMKRMVIPDALKVLRLQKGHKYCLLGKLSSEVGWNHYDTIKELERKRKERAQVAYERRKQLIKLRVKAEKVAEEKLGAQLEVIAPIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UW50</accession>
    <name>A0A0D2UW50_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G301200</name>
        <name evidence="7" type="ORF">Gorai_013026</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UW50"/>
    <dbReference type="STRING" id="29730.A0A0D2UW50"/>
    <dbReference type="Gramene" id="KJB60341">
        <property type="protein sequence ID" value="KJB60341"/>
        <property type="gene ID" value="B456_009G301200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60342">
        <property type="protein sequence ID" value="KJB60342"/>
        <property type="gene ID" value="B456_009G301200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60343">
        <property type="protein sequence ID" value="KJB60343"/>
        <property type="gene ID" value="B456_009G301200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60344">
        <property type="protein sequence ID" value="KJB60344"/>
        <property type="gene ID" value="B456_009G301200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60345">
        <property type="protein sequence ID" value="KJB60345"/>
        <property type="gene ID" value="B456_009G301200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770648"/>
    <dbReference type="eggNOG" id="ENOG502QR11">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LMQIYMP"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14707">
        <property type="entry name" value="bZIP_plant_BZIP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000036">
        <property type="entry name" value="ABSCISIC ACID-INSENSITIVE 5-like protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043452">
        <property type="entry name" value="BZIP46-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952:SF385">
        <property type="entry name" value="ABSCISIC ACID-INSENSITIVE 5-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22952">
        <property type="entry name" value="CAMP-RESPONSE ELEMENT BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="249"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB60345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0596195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="321" mass="35739" checksum="6298EAED4B7507EC" modified="2015-04-29" version="1">MGIQTMGSQGDSGSNGKQLQFQQLTQQNSMYSLTLDEVQNQLGDLGKPLSSMNLDELLKNVWTLEANQTFGMDSDGTVLTNQASLQRQASLSLTGALSKKTVDEVWRDIQQSKNDGEKKSRERQPTLGEMTLEDFLVKAGVVAEASTDGDVGASIAGVDLSVAPQFAQQGQWMQYPQPQYHHPQQSIMGVYMPPQPMPRPLALGTAAVMDVSYPENQVPLHSPLMGTLSDTQASGRKRGAPEDIVEKNVERRQKRMIKNRESAARSRARKQAYTNELENKVSRLEEENERLRKRKELEKLLPSAPPPEPKYQLRRTSSAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UZT3</accession>
    <name>A0A0D2UZT3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G001500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="5">The Mn(2+) ion enhances activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UZT3"/>
    <dbReference type="STRING" id="29730.A0A0D2UZT3"/>
    <dbReference type="MEROPS" id="M20.A06"/>
    <dbReference type="Gramene" id="KJB74614">
        <property type="protein sequence ID" value="KJB74614"/>
        <property type="gene ID" value="B456_012G001500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780358"/>
    <dbReference type="eggNOG" id="ENOG502QQEM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITSACDR"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009850">
        <property type="term" value="P:auxin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08017">
        <property type="entry name" value="M20_IAA_Hyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000001">
        <property type="entry name" value="N-acetyldiaminopimelate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044757">
        <property type="entry name" value="ILR1-like_Hyd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014:SF140">
        <property type="entry name" value="IAA-AMINO ACID HYDROLASE ILR1-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PEPTIDASE M20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253108" description="Peptidase M20 dimerisation domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="7">
        <location>
            <begin position="212"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005962-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB74614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="428" mass="46741" checksum="17C80542D38257AD" modified="2015-04-29" version="1">MVARLHTLLVSLACLSAIHGRVDHDYKDQLLSSAQQEKDWLVSIRRQIHENPELLFQEHNTSALIRQHLDQLGIPYSYPFAKTGIVAQIGSGSKPIVALRADIDALPLQELVDWEHRSKIDGKMHACGHDAHTTMLLGAAKLLNQRKDRLKGTVRLLFQPAEEGGAGASHMIKEGALGDAEAIFGMHIDYSTLTGSITLVSGPVLAATCIFEAKIEGVGGHAAGPHSTVDPILAASFTILALQQLISREADPLHSQVLSVTFIRGGSAFSVIPSYVEFGGTLRSLTTEGLHKLQQRLKEVIKGQAAVHRCKAFIDMKEKDHPVYPAVVNDDGLHQHVQKVGSLLLGPENVKRGKKIMAGEDFAFYQEKIPGFMLSIGIRNEELGSIHPPHSPYFFLDEDVLAIGAALHTALAELYLNEHKHSILDEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2T7</accession>
    <name>A0A0D2V2T7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G065200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
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    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V2T7"/>
    <dbReference type="STRING" id="29730.A0A0D2V2T7"/>
    <dbReference type="Gramene" id="KJB75944">
        <property type="protein sequence ID" value="KJB75944"/>
        <property type="gene ID" value="B456_012G065200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779466"/>
    <dbReference type="eggNOG" id="KOG2529">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000012">
        <property type="entry name" value="tRNA pseudouridine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="6">
        <location>
            <begin position="313"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA pseudouridylate synthase B C-terminal" evidence="7">
        <location>
            <begin position="464"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB75944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="511" mass="59011" checksum="C4CC5E27C117ACE4" modified="2015-04-29" version="1">MSLHLLRPKILYFFTAIGSSRLLSSKSCNFTNKLIFSKQPFSSFFFSTTSTPYPLQYDMIINTPTQSQPTPTRRRLSKPDSPNSPEEEDPEKELGFDSWVQKKLTSEEEMDKSKRKYYKKRRKRMYGSDSEDDDKGKNEDGFVELKPKVVEFDRLHEREEELYFYDTFAYPWENDKHYKMVYQLEKKYFPDQCFDKAFLEPGESNEKIKIKGKSKKTDDNNKKNNKVEDKGLVFFEEEENSGEDVKEKVTEKKVEEFFKCLKKVPNKETDDGEPYLVSRSTGLPTRWDGPYGTVVLVNKPKGWTSFTVCGKLRRLVKVKKVGHAGTLDPMATGLLIVCVGKATKLVERYQGMVKGYSGVFRLGEATSTWDADSPVIQREPWEQIKDEDIKKAAASFCGEIWQVPPMFSAIKVGGERMYEKARKGETVELSPRRISIFHFDIERSLEDRQNLIFRVTCSKGTYIRSLCADFGKALGSCAHLTALRRDSIGEYSAEDAWEFKELEEAITKGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4N9</accession>
    <name>A0A0D2V4N9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G125900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2V4N9"/>
    <dbReference type="Gramene" id="KJB77211">
        <property type="protein sequence ID" value="KJB77211"/>
        <property type="gene ID" value="B456_012G125900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779913"/>
    <dbReference type="eggNOG" id="KOG2772">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATECYYQ"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000174">
        <property type="entry name" value="Transaldolase type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002881">
        <property type="entry name" value="PRK03343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF31">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB77211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="442" mass="48019" checksum="DB68CB0282E319EE" modified="2015-04-29" version="1">MATISKLSNPNPVASLSSSFKPRSSSSLKCFVGFPTRPGFSSKLVSSSSLSSINTHPFRGSLVVRCSLADGNGSSVKRTTLHDLYEKEGQSPWYDNLCRPVTDLLPLIASGVRGVTSNPAIFQKAISSSNAYNDQFRELVQSGKDIESAYWELVVKDIQDACKLFEPIYDQTDGGDGYVSVEVSPRLADDTNGTIEAAKYLHEVVDRPNVYIKIPATAPCIPSIKEVIANGISVNVTLIFSLARYEAVIDAYLDGLEDSGLSDLSRVTSVASFFVSRVDTLIDKMLEMIGTPEALDLRGKAAVAQAALAYRLYQKKFSGPRWEALVKKGAKKQRLLWASTSVKNPAYPDTLYVAPLIGPDTVSTMPDQALQAFIDHGTVSRTIDANVSEAEGIYSALEKLGIDWGKVGSQLEDEGVESFKKSFDSLLDTLQEKANTLKFVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5I2</accession>
    <name>A0A0D2V5I2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2'-phosphotransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_010G043000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5I2"/>
    <dbReference type="Gramene" id="KJB64320">
        <property type="protein sequence ID" value="KJB64320"/>
        <property type="gene ID" value="B456_010G043000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB64320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25110" checksum="B0C7E6EC81899745" modified="2015-04-29" version="1">MFGNDFPVYPSPSEQSAADGAQKQKLDDADKKIVVFFFHNSIPFSAAKSMYLHVEFYISKLSDQFTNAGKKQMSCAERGRRKRTVHAVRKDNKQRFSVLEENGELLIRTNQGHTTVESERLLKQILSADEVQFCVHGTYKRNLESILESGLKRMKRLHVHFSSGLPTDGEVTSGMRRDVNVLIYLDVRKALEGFDGVVPVKCFEKIESWPDRKPIPFLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5Q7</accession>
    <name>A0A0D2V5Q7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Triosephosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G153600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5Q7"/>
    <dbReference type="STRING" id="29730.A0A0D2V5Q7"/>
    <dbReference type="Gramene" id="KJB77731">
        <property type="protein sequence ID" value="KJB77731"/>
        <property type="gene ID" value="B456_012G153600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779606"/>
    <dbReference type="eggNOG" id="KOG1643">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CRPVVAM"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB77731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="33130" checksum="42720F01BDD28BAC" modified="2015-04-29" version="1">MAMISTYCPHFNGLRRSSPKLDSSQSQSFLQHINSQLRLASSRKPCRAVTAMAGSGKFFVGGNWKCNGTKDSITKLVSDLNSTKLETDVDVVVSPPFVYLDQVTASLTGRIEVSAQNSWIGKGGAFTGEISVEQLKDIGCKWVILGHSERRHIIGEDDQFIGKKAAYALNEGLGVIACIGELLEEREAGKTFDVCFQQLKAFADVVPSWDNIVIAYEPVWAIGTGKVATPQQAQEVHVAVRDWLKKNVSEEVASKTRIIYGGSVNGSNCAELAKQEDIDGFLVGGASLKGPEFATIVNSVTSKKVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V789</accession>
    <name>A0A0D2V789_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G163100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V789"/>
    <dbReference type="STRING" id="29730.A0A0D2V789"/>
    <dbReference type="Gramene" id="KJB77884">
        <property type="protein sequence ID" value="KJB77884"/>
        <property type="gene ID" value="B456_012G163100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS9I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWNDLFI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025846">
        <property type="entry name" value="TBL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF12">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14416">
        <property type="entry name" value="PMR5N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Trichome birefringence-like N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="7">
        <location>
            <begin position="121"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB77884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="411" mass="46817" checksum="D959312075C25CC9" modified="2015-04-29" version="1">MAATKKLSSLFPLLSLICFISFFLLLSISRKASISSSTTHPQFLRFKPIDANLTTRSDPSATGDSSCDYSDGSWVYDPNAGFDRYDSSCKEIFKGWNCILNNKSNGRDIIKWRWKPRNCDLPPFDPLQFLHTYRDTNIGFIGDSLNRNMFVSLFCTLKRVSNDVKKWRPAGADRGFTFLHYNLTIAYHRTNLLARYANGNGGKLEALGYKEGYRVDVDVPESTWEKAPSFHDILIFNTGHWWWAPSKFDPVKSPLLFFEKGLPVIPPIPPDLGLDKVLNHVIRFVEKTMRPDAIKLFRTQSPRHFEGGDWDQGGSCQRLQPLLPEQVENLFSLKNNGTNVETRLVNQHIYNALKGSNVHVLDITRMSEFRADAHPSTAGGKKHDDCMHWCLPGVTDTWNDLFVTHLNSLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V820</accession>
    <name>A0A0D2V820_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G186500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB78234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V820"/>
    <dbReference type="Gramene" id="KJB78234">
        <property type="protein sequence ID" value="KJB78234"/>
        <property type="gene ID" value="B456_012G186500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779597"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ARESKMH"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901957">
        <property type="term" value="P:regulation of cutin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000099">
        <property type="entry name" value="MYB transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1347">
        <property type="entry name" value="MYB TRANSCRIPTION FACTOR MIXTA-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB78234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="308" mass="34670" checksum="64A923EA292AAA0B" modified="2015-04-29" version="1">MGRSPCCEKVGLKKGPWTPEEDQKLLAYIEQHGHGSWRALPLKAGLQRCGKSCRLRWINYLRPDIKRGKFSLQEEQTIIQLHALLGNRWSAIATHLPKRTDNEIKNYWNTHLKKRLTKMGIDPVTHKPKTNALGSTTGNPKDAANLSHMAQWESARLEAEARLVRESKLVPSNPPQSNHFTAVAPSPTPATRPQCLDVLKAWQGVVCGLFTLNMDNNNLQSPTSTLNFMENTTTLPMSSSSVNGMFNENFGWNSSFNPCESGDILKVEYGSDQIPELKERLDHPMELHEMDCSSEGTWFQELFGFNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V8X4</accession>
    <name>A0A0D2V8X4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G007300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V8X4"/>
    <dbReference type="STRING" id="29730.A0A0D2V8X4"/>
    <dbReference type="Gramene" id="KJB78569">
        <property type="protein sequence ID" value="KJB78569"/>
        <property type="gene ID" value="B456_013G007300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782353"/>
    <dbReference type="eggNOG" id="KOG1768">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EACAFEM"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="86"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB78569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="128" mass="14719" checksum="7B0DC37990AD4CFF" modified="2015-04-29" version="1">MTFKRRNGGRNKHGRGHVKFIRCSNCGKCCPKDKSIKRFLVRNIVEQAAVRDVQEACVYDTYTLPKLYVKMQYCVSCAIHSHVVRVRSRTDRRKRDPPARFIRRRDDMPKPGQPGQAPRPGVAVPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V981</accession>
    <name>A0A0D2V981_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G015700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V981"/>
    <dbReference type="STRING" id="29730.A0A0D2V981"/>
    <dbReference type="Gramene" id="KJB78749">
        <property type="protein sequence ID" value="KJB78749"/>
        <property type="gene ID" value="B456_013G015700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783518"/>
    <dbReference type="eggNOG" id="ENOG502S1J2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CFQDPQF"/>
    <dbReference type="OrthoDB" id="1918588at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040414">
        <property type="entry name" value="CID1/CID2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33790">
        <property type="entry name" value="OS05G0344200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33790:SF1">
        <property type="entry name" value="PROTEIN EARLY RESPONSIVE TO DEHYDRATION 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB78749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="140" mass="16548" checksum="7353B194CBA764F3" modified="2015-04-29" version="1">MEILPQRSSLSSTLNPNAPLFIPLAYRMVKDFSDQWWALVQSSPCFRDYWLQERFHDPENDDVSDDDDDPLFPDDLDDIFEQYDDVLLDPRPEEKEKKLVPFGTSKWRKDRVVTESPRFIEKAPKIVNVKVSPRTIHQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V9H2</accession>
    <name>A0A0D2V9H2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G126500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V9H2"/>
    <dbReference type="STRING" id="29730.A0A0D2V9H2"/>
    <dbReference type="Gramene" id="KJB66080">
        <property type="protein sequence ID" value="KJB66080"/>
        <property type="gene ID" value="B456_010G126500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERTKTCI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler B.E."/>
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                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Thrash A."/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Shu S."/>
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                <person name="Byers R."/>
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                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
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                <person name="Grover C."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31300:SF2">
        <property type="entry name" value="LIPASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04788">
        <property type="entry name" value="DUF620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="471" mass="51169" checksum="A0174CDADD20A9F3" modified="2015-04-29" version="1">MEKKQGFFSSLKEDVIRGLSPSRSRSNSLARTGSPMSGLLRRKKTSNQYYAGGGGYVAQPEPLIARSGSLRPVGEALAPLMEGPDPDGVEIGDSKRVGSGIGQWVKGQLSRNPSVTASYKRSDLRLLLGVMAAPLAPVHVNCNDPLPHLSIKDTPIETSSAQYILQQYTAASGGQKLQNSIRNAYAMGKLKMVACEYETATRTVKNRNGSKGAESGGFVLWQMNPDMWYVELAVGGSKVRAGCNGKLVWRHTPWLGSHTAKGPVRPLRRALQGLDPRTTAGMFADARCIGEKNVNGEDCFILKLCTEPQTLKARSEGPAEIIRHVLFGYFSQKTGLLVHIEDSHLTRIQSNGGDAVYWETTIDSYLDDYRPVEGIMIAHSGRSVVTLFRFGEVAMSHTKTKMEEAWTIEEVAFNVPGLSVDCFIPPGDLKSGSIGETCELPQDEKGKTAIVLAAQRAKLAAAGNTIWKMEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W399</accession>
    <name>A0A0D2W399_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_013G059800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W399"/>
    <dbReference type="SMR" id="A0A0D2W399"/>
    <dbReference type="STRING" id="29730.A0A0D2W399"/>
    <dbReference type="Gramene" id="KJB79630">
        <property type="protein sequence ID" value="KJB79630"/>
        <property type="gene ID" value="B456_013G059800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782247"/>
    <dbReference type="eggNOG" id="KOG0841">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="7"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB79630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="261" mass="29439" checksum="0B8EF9203CBEA8A0" modified="2015-04-29" version="1">MATSSPREDNVYMAKLAEQAERYEEMVKFMETVVSAVPSSDELSVEERNLLSVAYKNVIGARRASWRIVSSIEQKEEGRGNADHVSVIREYRAKIEAELSEICAGILKLLDEKLVPAAKTGDSKVFYLKMKGDYHRYLAEFKTGDDRKAAAENTLTAYKSAQEIATSELAPTHPIRLGLALNFSVFYYEILNSPDRACSLAKQAFDEAISELDTLGEDSYKDSTLIMQLLRDNLTLWTSDMQDDATDEIKEAPKREEEKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LV38</accession>
    <name>A0A0D2LV38_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Floricaula/leafy-like transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G053900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Probable transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FLO/LFY family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LV38"/>
    <dbReference type="SMR" id="A0A0D2LV38"/>
    <dbReference type="STRING" id="29730.A0A0D2LV38"/>
    <dbReference type="Gramene" id="KJB07932">
        <property type="protein sequence ID" value="KJB07932"/>
        <property type="gene ID" value="B456_001G053900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785701"/>
    <dbReference type="eggNOG" id="ENOG502QSDD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1875842at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4180.10">
        <property type="entry name" value="Protein LEAFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035209">
        <property type="entry name" value="FLO/LFY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002910">
        <property type="entry name" value="FLO_LFY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038276">
        <property type="entry name" value="Floricaula/leafy_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035079">
        <property type="entry name" value="LFY_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36079">
        <property type="entry name" value="PROTEIN LEAFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36079:SF1">
        <property type="entry name" value="PROTEIN LEAFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17538">
        <property type="entry name" value="C_LFY_FLO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01698">
        <property type="entry name" value="SAM_LFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="5 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Floricaula/Leafy protein SAM" evidence="11">
        <location>
            <begin position="53"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Floricaula/leafy DNA-binding C-terminal" evidence="12">
        <location>
            <begin position="222"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="158"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB07932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="406" mass="44969" checksum="7DF69A6281AF94DA" modified="2015-04-29" version="1">MDPETFASGSFFKWDPRGLMAPTPARLVEAVAAVPQPQAVAVAAAAAFMGRPRELGGIEELFQAYGIRYYTAAKIAELGFTVNTLLGMKEEELDEMMNSVSQIFRWELLVGERYGIKAAVRAERRRLEEEDSRRRHLVLGDTTTTTTAANALDALSQEGLSEEPVQQEKEAAGSGGGGTWEMVIGGGRRKQQRRRKGQKKVVEVDNGDEFEGGDDDDENGDGGGGGYERQREHPFIVTEPGEVARGKKNGLDYLFHLYEQCRDFLIQVQNIAKDRGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDEEASNALRRAFKERGENVGAWRQACYKPLVSIAARQGWDIDAIFNAHPRLAIWYVPTKLRQLCHAERNGAAAVAAGSSSVSGGHDHMGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M2R1</accession>
    <name>A0A0D2M2R1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Large ribosomal subunit protein uL4 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G248400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M2R1"/>
    <dbReference type="STRING" id="29730.A0A0D2M2R1"/>
    <dbReference type="Gramene" id="KJB11232">
        <property type="protein sequence ID" value="KJB11232"/>
        <property type="gene ID" value="B456_001G248400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767325"/>
    <dbReference type="eggNOG" id="KOG1475">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="5">
        <location>
            <begin position="284"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="409" mass="45155" checksum="9814886EEF0EF6F5" modified="2015-04-29" version="1">MAAAAAAAARPLVSVQTIDSDMATDSTQTVPLADVMKASIRPDIVTFVHDNISKNRRQPYAVSKRAGHQTSAESWGTGRAVSRIPRVPGGGTHRAGQGAFGNMCRGGRMFAPTKIWRRWHRKINVNQKRYAVASAIAASAVTSLVMARGHRIEAVPEMPLVISNAVESVEKTSAAIKVLKQVGAYPDVEKAKDSVGIRPGKGKMRNRRYISRKGPLIVYGTEGAKLVKAFRNIPGVEVANVERLNLLKLAPGGHLGRFIIWTKSAYEKLDSIYGSFEKPSEKKKRYILPRSKMVNADLGRIINSDEVQSVVKPIKKEIKRAPLKKNPLKNLNAMLKLNPYAKTARRMALLAEAQRVKAKKEKLDKKRKPVSKEEATAIKSAGKAWYKTMISDSDYTEFENFSKWLGVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M672</accession>
    <name>A0A0D2M672_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G033500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M672"/>
    <dbReference type="STRING" id="29730.A0A0D2M672"/>
    <dbReference type="Gramene" id="KJB12732">
        <property type="protein sequence ID" value="KJB12732"/>
        <property type="gene ID" value="B456_002G033500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSUU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCCSINI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00028">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01098">
        <property type="entry name" value="PAN_AP_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000001">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000418">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32444:SF198">
        <property type="entry name" value="BULB-TYPE LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00473">
        <property type="entry name" value="PAN_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002258509" evidence="4">
        <location>
            <begin position="25"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="6">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="7">
        <location>
            <begin position="338"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="466"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="553" mass="62025" checksum="5F10181AB56A8493" modified="2015-04-29" version="1">MGKTISCSVLLALISCFYLPFGTALDTITASKSIKDPDVIISQSGVFRLGFFSFANSSNRYVGILYNQIPIQTVVWVANKNKPLKDFSGILKISDDGNLVVLNGKAEILWSSKVKNLVPNATTAQLLDSGNLVLNNGVNSLWESFQDPSNAFLETMKISTDVKTSRKVEIKSWKSPDDPSDGNFSLSLEHFNIPESAIWNNNQLYYRSGPWNGQSFIGVMNMNTVYLDGFYLVSDDKQQTYYFTYQYSNNSWSLHYELDSQGNLIGRQWDAGKGDWINWYAVLQTDCNVYGKCGPFGMCDPTKRPICSCLKGFKPRNREEWSRGNWSSGCFRTTLLQCQRDNNNGSGAGQGDDGFLKLKMMKVPAFPDRSSLINGDCKDQCLKNCSCVAYAYDDGIGCMFWGGDLIDVQKFSTRGVDLYIRLPSSELGRNKIWRQIEDVEENLIGAKLQQLPLFNFEELATATDNFHHTKKLGQGGFGPVYRGTLDDGKEIAVKRLSKASGQGLEEFMNEVVVISKLQHRNLVKLFGCCVEGEEKMLVYEYMPNKSLDSFLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MA61</accession>
    <name>A0A0D2MA61_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_002G126500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MA61"/>
    <dbReference type="STRING" id="29730.A0A0D2MA61"/>
    <dbReference type="Gramene" id="KJB14472">
        <property type="protein sequence ID" value="KJB14472"/>
        <property type="gene ID" value="B456_002G126500"/>
    </dbReference>
    <dbReference type="OMA" id="IMASATC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45764:SF38">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="61"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="187" mass="21753" checksum="550B1F17EB021C5F" modified="2015-04-29" version="1">MSPVVSEILRSGFMINSSLRRRTHLVQSFSVVFLHCGNSNSSGSTLLQISGSEEDLHRLMDERKRKRMESNRESARRSRMRKQKYLDDLMAQLTLLRKDNNQILTSINFITHHYFNIEAENSVLRAQFMELSQRLDSLNHILNYLNDPTLNNGIWVYETEPFETSADSFTNFTLNQPIVASADIFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MBR3</accession>
    <name>A0A0D2MBR3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAT C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G161200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MBR3"/>
    <dbReference type="Gramene" id="KJB15112">
        <property type="protein sequence ID" value="KJB15112"/>
        <property type="gene ID" value="B456_002G161200"/>
    </dbReference>
    <dbReference type="OMA" id="VEWWMIY"/>
    <dbReference type="OrthoDB" id="1001566at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008906">
        <property type="entry name" value="HATC_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05699">
        <property type="entry name" value="Dimer_Tnp_hAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAT C-terminal dimerisation" evidence="2">
        <location>
            <begin position="107"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="467" mass="53277" checksum="574CB1C1C1611E53" modified="2015-04-29" version="1">MGFIYEAVDRAKRAIQQNCRYFTEYEKIIDNRWNFMHFDLHSAGYFLNPQFQFGVEHSENVLIETLEGTRSVIERLEPSMDTQVRMVNQLLLFRDKHETLGTSQAQRAWKQMNPVEWWMIYGTCVPELQKLAIKVLSQTTSASNCERNWSTFSYIHTKARNRLKYKKLEKLVFTYYNMRLKMRHQQKMSTGDINASFNPISLDYIFEGVDPLSEWLHEKENPLLDGENAGVLPLDTSDDEMDVDQSQQQILSHSSSSSTPSQSGDGPDGGGLSPIDEDDGYSGDRGEIRSSSQYGGEYGGGTTGGHFRDKSEFDGNMFPEPRRDRSEPRAPSKGKGKKHTSIGSSSGRRSSSSNLGYSDSSTSTQGFYPPEQPSHGYPQPYGYYPPFPNYGVPYQPQMHPPPPMYHPPPPFMYPPPQIYPPYQLNENQGENVTFFGYIFGQRARESSQERSQSEGEGFDLPRHSTNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MSD2</accession>
    <name>A0A0D2MSD2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G021100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MSD2"/>
    <dbReference type="STRING" id="29730.A0A0D2MSD2"/>
    <dbReference type="Gramene" id="KJB21917">
        <property type="protein sequence ID" value="KJB21917"/>
        <property type="gene ID" value="B456_004G021100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVMN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKLWCSW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013187">
        <property type="entry name" value="F-box-assoc_dom_typ3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017451">
        <property type="entry name" value="F-box-assoc_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01640">
        <property type="entry name" value="F_box_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF13">
        <property type="entry name" value="F-BOX PROTEIN CPR30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08268">
        <property type="entry name" value="FBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB21917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="377" mass="44172" checksum="704D8A51081375E4" modified="2015-04-29" version="1">MATLSHDMIIEILGCLSVKDLLRFKCVSKLWCSWIEDPYFIKLHLSYSLKTNTNHSLILHHRKFQFLSVNYDSPKTTRRLEQPFGEQKNPIQILGSCNGLLAVEYDYNRIFLWNLSTRKYQVLPSTKIDFSSSSICYGRSIYYGFGYDLVSDDYKLVRMVQLLGENDEYFHSEAKVYSLRSNCWRRIKDFCFYLIFYRELGFLANNVLHWMVSKTPESSNRNLVGFDLRSEEFRVVELPDFCLDENFYFDVKAMGGYLCLTATHRELNDVVVDVWIMKEYGVKESWVKLMSSTQPDLLPGSPFEVPLAFSKNGNKVLFHNKYSRGNRDSLVWYDLGSKRVEKVAIEGVPVVYDVYLYVESLVPLNDRRPRDVFNLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MUM7</accession>
    <name>A0A0D2MUM7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit delta', mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">F-ATPase delta' subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_004G068100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUM7"/>
    <dbReference type="STRING" id="29730.A0A0D2MUM7"/>
    <dbReference type="Gramene" id="KJB22816">
        <property type="protein sequence ID" value="KJB22816"/>
        <property type="gene ID" value="B456_004G068100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22817">
        <property type="protein sequence ID" value="KJB22817"/>
        <property type="gene ID" value="B456_004G068100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790599"/>
    <dbReference type="eggNOG" id="KOG1758">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTTMKWR"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000005">
        <property type="entry name" value="ATP synthase delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.440">
        <property type="entry name" value="ATP synthase delta/epsilon subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF14">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA', MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="16">
        <location>
            <begin position="70"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00067584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00078690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB22817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="200" mass="21342" checksum="3F7F21DE2299E332" modified="2015-04-29" version="1">MLRRALGLLPRPIAAARARSFSTDLPAAHTADATFMEAWNKVMPNMDPPKTPLSFMHPRPPTPSSIPPKLTVNFVLPYASELSTKEVDMVIVPATTGQMGVLPGHVATIAELKPGVLSVHEGSETTKYFVSSGFVFIHANSFADIIAVEAVPLDRIDANLVQKGLADFTQKLSSATTELEKAEAQIGIDVHSALNSALTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MXS8</accession>
    <name>A0A0D2MXS8_GOSRA</name>
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                <person name="Zhang D."/>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="48"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="48"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="8">
        <location>
            <begin position="100"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB36867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0588140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="398" mass="43525" checksum="F6CDB79F88BD92E8" modified="2015-04-29" version="1">METEVEAVDNGNGTTVAEINVPSPPPLDGGEGGDCGSRDDSAAGGRTRKQRVKGPWSPEEDAILSELVSKFGARNWSLIARGIAGRSGKSCRLRWCNQLDPAVKRKPFTDEEDRMIISAHAVHGNKWAVIARLLPGRTDNAIKNHWNSTLRRRYMDLGRINTESANMMEDAGCLDKTKASSEETLSCAEDSSFRSLEWKDASSSEKLDNQSKGKALAGTQSNHELIEPPTLFRPVARISAFNVYNNMDAPEFVSPCSRPVPVLGPSIQTSKPDVGTCKLLEGVYTDRLVPLHCGHGCCGTQNGQNKSLLGPEFVEFSEPPSFPNYELAAIATDISNLAWLKSGLENNSVRAMDDATAGTSHRSQVHMGHFEESQMSDRLRIEERNSKFMGTMTNLLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NYY3</accession>
    <name>A0A0D2NYY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pectate lyase superfamily protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G266100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NYY3"/>
    <dbReference type="STRING" id="29730.A0A0D2NYY3"/>
    <dbReference type="Gramene" id="KJB38662">
        <property type="protein sequence ID" value="KJB38662"/>
        <property type="gene ID" value="B456_006G266100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800777"/>
    <dbReference type="eggNOG" id="ENOG502QS3K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YPNDNQT"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000012">
        <property type="entry name" value="Polygalacturonase At1g48100 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31375">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB38662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="51662" checksum="D065BE5D22158301" modified="2015-04-29" version="1">MDLAHVCFFIWILAILTFYQHPINVNARYHYHKKQQKTKGSPFIDEAPAPAPALVPSTSADPPSIPSDPYPTDPGDTSDCIFDVTAYGAVGDGSSDDTAAFREAWKAACSVESATILVPSDNIFTITSTIFSGPCKPGLVLQVNGVLMPPKGPDCWPKADSRKQWLVFYRLDDMKLTGNGTIEGNGHEWWELPCKPHRGPKGSSLPGPCESPAMIRFFMSSNIVVSGLRVQNSPQFHMKFDGCEGVLIEELSISTPKLSPNTDGIHIENTKSVGIYNSMISNGDDCISIGPGCSNVDINGVTCGPSHGISIGSLGVHNSQACVSNITVRNAVIRESDNGVRIKTWQGGTGSVSGISFENIQMENVRNCIIVDQYYCLSKECLNQTSAVYVTDIRYKNIKGTYDVRNPPIHFACSDTVACTNITMAEVELLPQEGELVDDPFCWNAYGIEETLSIPPIGCLQEGMPQAITETSQYSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P285</accession>
    <name>A0A0D2P285_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLATZ transcription factor family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G032400</name>
        <name evidence="3" type="ORF">Gorai_017844</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0589077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P285"/>
    <dbReference type="STRING" id="29730.A0A0D2P285"/>
    <dbReference type="Gramene" id="KJB39827">
        <property type="protein sequence ID" value="KJB39827"/>
        <property type="gene ID" value="B456_007G032400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802008"/>
    <dbReference type="eggNOG" id="ENOG502QQYG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GHCKFHV"/>
    <dbReference type="OrthoDB" id="1908108at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006734">
        <property type="entry name" value="PLATZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31065">
        <property type="entry name" value="PLATZ TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31065:SF48">
        <property type="entry name" value="PLATZ TRANSCRIPTION FACTOR FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04640">
        <property type="entry name" value="PLATZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB39827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0589077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24254" checksum="F3C6B45EDE810BE1" modified="2015-04-29" version="1">MGAGGPDEEDNRWPPWLKPLLKEQFFVQCKHHVDFHKSECNMFCLDCVNGALCSFCLAYHKDHRYIQIRRSSYHDVIRVSEIQKYLDISGVQTYIINSAKIVFLNERPQPRPGKGVTNTCEVCDRSLVDSFRFCSLGCKIVGTSKNFHKKKRQLGMNMAALDSEDSYSSSCHEKINNKVQSFRPSTPPPTRTAKRRKGIPHRAPMGGLIIEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4N9</accession>
    <name>A0A0D2P4N9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Subtilisin-like protease SBT4.3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_004G002500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21603">
        <property type="protein sequence ID" value="KJB21603"/>
        <property type="gene ID" value="B456_004G002500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRA7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKSYKCP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02120">
        <property type="entry name" value="PA_subtilisin_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04852">
        <property type="entry name" value="Peptidases_S8_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000002">
        <property type="entry name" value="Subtilisin-like protease SBT5.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034197">
        <property type="entry name" value="Peptidases_S8_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045051">
        <property type="entry name" value="SBT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041469">
        <property type="entry name" value="Subtilisin-like_FN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10795">
        <property type="entry name" value="PROPROTEIN CONVERTASE SUBTILISIN/KEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17766">
        <property type="entry name" value="fn3_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002260329" description="Subtilisin-like protease SBT4.3" evidence="9">
        <location>
            <begin position="26"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="132"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="11">
        <location>
            <begin position="651"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="10">
        <location>
            <begin position="749"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="Subtilisin-like protease fibronectin type-III" evidence="12">
        <location>
            <begin position="1309"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="757"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="812"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7 8">
        <location>
            <position position="1135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB21603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1350" mass="144328" checksum="235C1590485806BC" modified="2015-04-29" version="1">MAMSSFLLFVDITVILMLCISLCHGAVEDDRKVYIAYLGAAPDREDIATSQHSAMLQSLSTLSSVENYLIKSYKRSFNGFAAKLTNEEAKKLASFKEVVSVFPSKVYHLQTTRSWDFLGLNQTVKRNATAESNVIVGVLDTGIWPESDSFSDEGFGPPPKKWKGACKGGQNFTCNNKLIGARAYHSDSARDTEGHGTHTASTAAGNNVVNASFYGLAEGIARGGVPSARIAAYKVCSGILCLSEDILAGFDDAIADGVDLISVSLGLEIPVDLYEDPVAIGAFHAAEKGVLVLQSAGNSGTTGFQSVSSVAPWILSVAASTTDRLFVDKVVLGNGWKTLTGFSVNSFSLNRTKVPLVYGLQITSSCDEAHARACYSYCLNKTLVKNKIVLCDVMNGVNAAYDAGALGLITKYQVENVSFVVPLSAITLSSKDYDLVISYHNSTKEPKAEILRSETIKDKFAPIVASFSSRGPNAFVPDILKPDISAPGVDILAAYSPVASPSTTTTDPRRVKYNIISGTSMSCPHVAGVAAYVKTFHPHWSPSAVKSALMTTAFPMDAPRTQGAEFAYGSGHINPVKAIDPGLVYDTVEGDNIRFLCSKPFKVTFHRTVTNVGVARCTYNATIATLSELEIKVVPQVLSFKSLTEKKSYNVYIAYLGSLPDGDYIASSHHCNMLSALSKHSSVENHLIRSYKRSFNGFAAKLTNEEAKKLSSFKGVVSVFPSKVYHLHTTRSWDFLGLNQTVKRNATESDVIVGVFDTGIWPESDSFSDEGFGPPPQKWKGACKGGQNFTCNNKLIGARVYITDSARDTEGHGSHTASTAAGNNVVNASFYGFAEGTARGGVPSARIAAYKVCNGICTSEDILAAFDDAIADGVDLITASLGSFFVFEFYSDAVAIGAFHAAEKGVLVVQSAGNSGLAGFQSVASVAPWILSVAASTMDRHFVNKVVLGNGKTLTGLSINTFSLNRAMVPLVYGMQASSDCDEFSARLCFPNCLNKTLVKNKIILCDDMQGVDEAYNAGALGLITKYGFDDVAYVVPMPAITLSSKDYDSVTSYLNSTKQPKAEILISETITDKSAPIVASFSSKGPNFIVPDILKPDISAPGVDILAAYSPVASPSITTTDTRRVKYNIISGTSMSCPHVAGVAAYVKTFHPHWSPSAIKSALMTTAFPMDAPRNQGAEFAYGSGHINPVKAIDPGLVYDNVKGDNIRFLCSIGYDEGSIKNIEGNNTSCPKNTFPMDAPRNQGAEFAYGSGHVNPVKAIDPGLVYDTVEGDNIRFLCSIGYDEGSIKKLAGNNTSCPKNSTKMLPRDFNYPTLTALVPAGKPFKVTFHRTVTNVGVARSTYNATIATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PCX8</accession>
    <name>A0A0D2PCX8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G163100</name>
        <name evidence="6" type="ORF">Gorai_014919</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJB24828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB24830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <location>
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            <end position="157"/>
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            <end position="414"/>
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        <location>
            <begin position="1"/>
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            <end position="158"/>
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        <location>
            <begin position="1"/>
            <end position="19"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB24828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0584088.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PG64</accession>
    <name>A0A0D2PG64_GOSRA</name>
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            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">B456_007G285300</name>
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    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
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        <reaction evidence="7">
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
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        <property type="entry name" value="Pkinase"/>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="282"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="544"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
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            <end position="657"/>
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    </feature>
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        <location>
            <begin position="670"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
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            <begin position="544"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="573"/>
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    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB45017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="727" mass="83617" checksum="6F5084396B2970E2" modified="2015-04-29" version="1">MNGLLHLEEPDCSEFVEVDPTGRYGRYNEILGKGASKTVYRAFDEYEGIEVAWNQVKLYDFLQSPEDLERLYCEIHLLKTLKHKNIMKFYTSWVDTANRNINFVTEMFTSGTLRQYRLKHKRVNIRAVKHWCRQILRGLLYLHSHDPPVIHRDLKCDNIFVNGNQGEVKIGDLGLAAILRKSHAAHCVGTPEFMAPEVYEEAYNELVDIYSFGMCILEMVTFEYPYSECTHPAQIYKKVISGRKPDALYKVKDPEVRQFVEKCLATVSLRLSARELLNDPFLQFDDCEYDLRQLEYGRELDEVGPLIRLPYLEFHHNSNSYSNGYKNGYGYETPNEWGYHPAEIEPSGIGLFEYQEDEHAANVDISIKGKMGNDGGIFLRLRIVDKEGRIRNIYFPFDVETDTALSVATEMVSELDITDQDVTKIADMIDGEIASLVPGWRRGPGIDESPRFSNQNFCHNCASNRTSTGSLLDFLTHNGGVKDSRVLQCCRTGCASMHGRFEEITFQVEESEHCVTDGAPNESSQSDNLHYQEIWDQHENHELRQRNSDKEFDKSDQSFLANGDKEVREEKKIQSPNRNSIQCLTSSRSFSEVHSLYCDLSDNYENEVQQELRWLKAKYQMELRELRDQQQLGIVSDSSNCSNKDKNRNNDIPPLSTFAPNKHFNSDFHYNKNKRCPDSANRGGRYHKPAESPRVKEMVTAQNFCTGSLLPQSLHRTISLPVDAVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PP75</accession>
    <name>A0A0D2PP75_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Excitatory amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G051900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PP75"/>
    <dbReference type="STRING" id="29730.A0A0D2PP75"/>
    <dbReference type="Gramene" id="KJB48057">
        <property type="protein sequence ID" value="KJB48057"/>
        <property type="gene ID" value="B456_008G051900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763096"/>
    <dbReference type="eggNOG" id="ENOG502S4FE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GILCYES"/>
    <dbReference type="OrthoDB" id="523796at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36052">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36052:SF1">
        <property type="entry name" value="EXCITATORY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB48057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9140" checksum="2F6434B043F85FBE" modified="2015-04-29" version="1">MAVSATVIGALLGLGTQMYSNALRKLPYMRHPWEHLLGMGMGAVFVNQLVNWDAQLQRDLDNMLEKAKAANERRYFDGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PQS5</accession>
    <name>A0A0D2PQS5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G231800</name>
        <name evidence="8" type="ORF">Gorai_021728</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PQS5"/>
    <dbReference type="STRING" id="29730.A0A0D2PQS5"/>
    <dbReference type="Gramene" id="KJB06315">
        <property type="protein sequence ID" value="KJB06315"/>
        <property type="gene ID" value="B456_001G231800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB06316">
        <property type="protein sequence ID" value="KJB06316"/>
        <property type="gene ID" value="B456_001G231800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB06317">
        <property type="protein sequence ID" value="KJB06317"/>
        <property type="gene ID" value="B456_001G231800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804512"/>
    <dbReference type="OMA" id="NRTIINC"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="149"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB06316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0579472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="204" mass="22623" checksum="0721237C2CAD4D9C" modified="2015-04-29" version="1">MNTIESRGPSLRGYQWRKVVLDLNAPPCEIIEQEGTSEQVGLKEVACQPVHPASPATIDVEVIDDDVTESSATAFAEAKNNSRRSSGRTVVDLDSGWLTRSTNNNQNKHRRPPPSQTVINCDHYINLESTPQFTVKEILKPQPPPTFNCPICMGPLTEEMSTRCGHIFCKACIKAAIAVQRKCPTCRKKVTVKELFRVFLPSAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PR02</accession>
    <name>A0A0D2PR02_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G135900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PR02"/>
    <dbReference type="STRING" id="29730.A0A0D2PR02"/>
    <dbReference type="Gramene" id="KJB09344">
        <property type="protein sequence ID" value="KJB09344"/>
        <property type="gene ID" value="B456_001G135900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1208">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VAYKIIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF200">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER FEY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB09344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="293" mass="32596" checksum="8234F7B3D26AF264" modified="2015-04-29" version="1">MAKRKQGLGWIEWLRGWMYVIYEMLFQRITASHLHNPLELPPLSDLTCIVTGSTSGIGREIARQLAEAGAHVVMAVRNPKAAHELINQWSASWHGLPLNIEVMQLDLLSLDSVVTFANAWNARLAPLHVLINNAGIFSIGEPQKFSKDGFEEHMQVNHLAPALLSILLLPSLIRGSPSRIINVNSVMHYVGFVDTEDMNAVTGKRKYSSLLGYTSSKLAQVMFSSVLHKRLPVEAGVNVLCVSPGIVHTNVARDLPRIVQAAYHLIPYFIFSAQEAHIFWEAYLSFAISIIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PRA6</accession>
    <name>A0A0D2PRA6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Response regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G142000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PRA6"/>
    <dbReference type="Gramene" id="KJB09429">
        <property type="protein sequence ID" value="KJB09429"/>
        <property type="gene ID" value="B456_001G142000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794585"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QYDQGDF"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17584">
        <property type="entry name" value="REC_typeB_ARR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000007">
        <property type="entry name" value="Two-component response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045279">
        <property type="entry name" value="ARR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874:SF63">
        <property type="entry name" value="RESPONSE REGULATORY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43874">
        <property type="entry name" value="TWO-COMPONENT RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="35"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="11">
        <location>
            <begin position="220"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="8">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB09429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="48907" checksum="5E9681A6BCAAC365" modified="2015-04-29" version="1">MTYVVGIKVIATTYTVCFFNAMDGGFDGDFPAGLKVLVVDENRTCLLVLETMLRKLSYEVTTCQLARHALALLREDKNRFDIVLCDLHMPEMDGLKLLEIIGLEMDLPVVMMSSDDGKGVIMKGIIHGACDYLVKPVQMEAVRLIWQHVVRKRQRALGDFQQLRGNIHATGRTLLLKQAKNAVDQMPARERRILKRARENDDEDEDDEDDEGELSEEVTTAKKPRVIWTQELHDIFVIAVNQLRQQAVPKKILERMQAMNVTGLSRANIASHLQKYRLHLRKGGGQPLADNRDVNLNPSIGQASSFNQFNLQFQQPTATGSSCNQLPMQNLMITPQPCTINDSVVPDSTQCFPTELSTNDLSQPNLLFQNDVPTSNVEHLYRNVGVNVSELSNPISSVDDSSVNQLIYEPSVLVRQYDQGDFFHGGFPRLETLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PWI8</accession>
    <name>A0A0D2PWI8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G174800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PWI8"/>
    <dbReference type="Gramene" id="KJB50512">
        <property type="protein sequence ID" value="KJB50512"/>
        <property type="gene ID" value="B456_008G174800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764444"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WACVFNT"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035251">
        <property type="term" value="F:UDP-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000064">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000143">
        <property type="entry name" value="UDP-glycosyltransferase 89B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047:SF28">
        <property type="entry name" value="F11M15.8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48047">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB50512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="52320" checksum="15A0439BCAD6A825" modified="2015-04-29" version="1">MSTTVNNCHILLFPYPAQGHMLPLLHLAHRLSLHGLTITIVITPKNLPYLSSLLSSHPSSITPLILPFPSHPSIPPGVENVKDLGHSGNLPMLTSLSKLHDPLLHWFNSHPDPPVAIISDFFLGWTLHLAHQLNIPRLVFFPSGAFLAAIDDYVWNNVEQLKTLDQVELSALPGSHVFKSHHLPSLFRLYKKSDPDWEFVKDLKLANTKSWGCVFNSFEAFEGEYMDYLKKKLSHDRIFGVGPLNLPGPGNLGSGSDLNERLLTWLDGCPKASVVYVCFGSQKLLKREQMEALALGLEKSGTRFVWVVKTGSTQEREDGFGNVPDGFEERVAGRGLVIREWAPQVSILSHEAAGGFLSHCGWNSVLEGIVGGVVILAWPMEADQFVNARLLVEDMGVGVRVCEGAGSVPEAGELSRVIGESMSEVGGLKDKAKELKEKALEAVSKEGSSVQDMGWLVGELRKLKPFKSRIQHTSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZ12</accession>
    <name>A0A0D2PZ12_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G143400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZ12"/>
    <dbReference type="Gramene" id="KJB09456">
        <property type="protein sequence ID" value="KJB09456"/>
        <property type="gene ID" value="B456_001G143400"/>
    </dbReference>
    <dbReference type="OMA" id="PHITWLP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="88" mass="9978" checksum="0A3252662606CAEF" modified="2015-04-29" version="1">MMKMDRCATWVCLKGHMISFSISSFNFCLPPQQKNNSSCNLVHPHPHPPSSPCHPMLLSTCHPSLYMCPHITWLPCHPNLKATNFCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZW7</accession>
    <name>A0A0D2PZW7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G027900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZW7"/>
    <dbReference type="Gramene" id="KJB12624">
        <property type="protein sequence ID" value="KJB12624"/>
        <property type="gene ID" value="B456_002G027900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXXN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFCHSIL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="76" mass="8978" checksum="6F427C68F23F882C" modified="2015-04-29" version="1">MINGSSRRDLLLNSQYFCHSILAGTENPLPSRLCYRRLWGSRNRRALILGWAYYLDAFNSYPLRTWLPSIYRGHDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5W1</accession>
    <name>A0A0D2Q5W1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1771 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G087000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_006G087000"/>
    </dbReference>
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        <property type="entry name" value="At5g58720/SDE5-like_UBA-like"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47872:SF3">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR SDE5 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47872">
        <property type="entry name" value="NUCLEAR RNA EXPORT FACTOR SDE5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UBA_At5g58720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="119"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="536" mass="60083" checksum="6ECA29D6BD7120F2" modified="2015-04-29" version="1">MEVSSLNGLQNEEEALNSLLDAFGSLFSLNDIASAYCEAGRNPDLAGLILCEMQGIPPLVATDQSNNEVKNNETSGSSYVKSSQNNSQASEVFTVDQPVSAATDECSGKRKKDEPMESSRCNSFQRSCQENGGLSSPKQKARPVSGGTVSSMLGKGYMKSVPLANGSYPGTKPMKVDSKEMPMSLFWGEELEPSSQNEDRMHKDMEDFLFKMLGEGFRLERDMIREVLNSCGYNMQKSMKKLLDWSAVSLDKEKKPSAMSLDKEKKPLGESGEKTNDIHLRTSRPSQENMNIVLNADVAERQQKDGNDLQKEVLAALFGAPERSEELPRRSKRPARRPIALGEIVERPLIDVTAEPKVDRVRSQEDKKDDEDEEDSFQVLRRAVKEYRGTMKEYYKAAVDAFAKGDQDEANKLLEQGQFFQEKARQADEESNQKIFETRNTETEDEMLLELHNHGTREAIQLLKCHLSSLAGIPSFKYLKVIINTDKEDSSKGTCRRLVMKLLQKESISWSEGETSGIILIQLDNINPKRLSFAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QDM3</accession>
    <name>A0A0D2QDM3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Shugoshin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G111300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shugoshin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QDM3"/>
    <dbReference type="Gramene" id="KJB56227">
        <property type="protein sequence ID" value="KJB56227"/>
        <property type="gene ID" value="B456_009G111300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770985"/>
    <dbReference type="eggNOG" id="ENOG502RYFF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDQNTDH"/>
    <dbReference type="OrthoDB" id="770508at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034090">
        <property type="term" value="P:maintenance of meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044693">
        <property type="entry name" value="SGO_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011515">
        <property type="entry name" value="Shugoshin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34373:SF8">
        <property type="entry name" value="SHUGOSHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34373">
        <property type="entry name" value="SHUGOSHIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07557">
        <property type="entry name" value="Shugoshin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin C-terminal" evidence="4">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB56227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="278" mass="31656" checksum="E3938BEEB73E3BB9" modified="2015-04-29" version="1">MGGERMAKRSSLGSLMRKRLSDITNTQSQPKPSNQEEKPQQIPPAAEDYINQLIKEKMTLIELVEERNKIIELSGTELQNLRTSLQKLQLQNWNLAQSNSQILAELNLGRDRVKALQHELVCKDALLKAKNLERKGKADINGQNTDHAAEDDDKACTRNRRRNARSQSMGPLTTSRRSGDKEKAENKRRCLRRRTARFKSQEAENLFEIDDLDYVGAQPDTPMHELAASSLSMEEACSNPRAENRSSIAARPLPLRKAVEKVQSYKEVPLNIKMRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIS1</accession>
    <name>A0A0D2QIS1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_009G188700</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="17">Plastid</location>
            <location evidence="17">Chloroplast thylakoid membrane</location>
            <topology evidence="17">Single-pass membrane protein</topology>
            <orientation evidence="17">Stromal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QIS1"/>
    <dbReference type="STRING" id="29730.A0A0D2QIS1"/>
    <dbReference type="MEROPS" id="M41.020"/>
    <dbReference type="Gramene" id="KJB57987">
        <property type="protein sequence ID" value="KJB57987"/>
        <property type="gene ID" value="B456_009G188700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHTEYSE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019684">
        <property type="term" value="P:photosynthesis, light reaction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010304">
        <property type="term" value="P:PSII associated light-harvesting complex II catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.210:FF:000003">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF113">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9 18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="21">
        <location>
            <begin position="296"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB57987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="694" mass="74715" checksum="F0578200024AA092" modified="2015-04-29" version="1">MVHITHGSDSVLHPCPKASMANSLLSSNFFGTQLPLSPPTPKTTRKLQVTRSILNNKPNSNHTFRALRSHATLAALFFSSVTPQALAVDNSPPTPPPVIEAQPTNPSPSNQSHFSQDLLLIAPKPQSQSSDLPEGSQWRYIEFLNAVKKGKVERVRFSKDGSVLQLSAVDGRRASVIVPNDPDLIDILAMNGVDISVSEGESGNGLFNFIGNLLFPFLAFAGLFFLFRRAQGGPGGPGGLGGPMDFGRSKSKFQEVPETGVTFADVAGADQAKLELQEVVDFLKNPDKYTALGAKIPKGCLLVGPPGTGKTPLARSVAGEAGVPFFSCAASEFVELFVGVGASRVRDLFEKAKSKAPCIVFIDEIDAVGRQRGAGLGGGNDEREQTINQLLTEMDGFSGNSGVIVLAATNRPDVLDAALLRPGRFDRQVTVDRPDVAGRVKILQVHSRGKALAKDVDFEKIARRTPGFTGADLQNLMNEAAILAARRDLKEISKDGITDALERIIAGPEKKNVVVSVRRRNWLPIMVFDFLYALKFTEAGHALVGALIPEYDPVAKISIIPRGQAGGLTFFAPSEERLESGLYSRSYLENQMAVALSGRIAEEVIFGEENVTTGASNDFMQVSRVARHMVERFGFSKKIGRVAIGGPGGNPFLGQQMSSQKDYSMATADVVDAEVRDLVETAYSRAKQINHNPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMW2</accession>
    <name>A0A0D2QMW2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_003G037100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QMW2"/>
    <dbReference type="STRING" id="29730.A0A0D2QMW2"/>
    <dbReference type="Gramene" id="KJB18166">
        <property type="protein sequence ID" value="KJB18166"/>
        <property type="gene ID" value="B456_003G037100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18167">
        <property type="protein sequence ID" value="KJB18167"/>
        <property type="gene ID" value="B456_003G037100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787747"/>
    <dbReference type="eggNOG" id="ENOG502QWA0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYFLDNF"/>
    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000002">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000003">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor ANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF101">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR AIL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="222"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="324"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB18166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="505" mass="55822" checksum="893A065C97D30B3B" modified="2015-04-29" version="1">MAPATVSNWLSFSLSPMEMLRSSSEPQFVSYEGSSAATASAASPHYLIDNFYANEWTNPKHQTQQPAMAADESSILSSFHHHQVPKLEDFLGDSSSIVRYSDNSQTETQDSSLTHLTQIYDHHHVGAAAYFNDHQDLKAITGFQAFSTNSGSEVDDSASMGRTQLAAVEFPGHSNCPTAGSLSLGVNQTSEINTTTTNKAVVSVDSDCSKKIVDTFGQRTSIYRGVTRHRWTGRYEAHLWDNSCRREGQARKGRQVYLGGYDKEEKAARAYDLAALKYWGPTATTNFPITNYSKELEEMKHVTKQEFIASLRRKSSGFSRGASIYRGVTRHHQQGRWQARIGRVAGNKDLYLGTFATEEEAAEAYDIAAIKFRGINAVTNFEMSRYDVEAIAKSSLPIGGAAKRLKISLESEQKPAVVNHEQQPQCSSNSNISFAPMQQSISTIPCGIPFDAAAFYQHNLYHHLQASNISISDLPGSSSTMTTTPTTLMSQPTADQFFLWPHQSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QS54</accession>
    <name>A0A0D2QS54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Gnk2-homologous domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_001G181200</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell junction</location>
            <location evidence="12">Plasmodesma</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cysteine-rich repeat secretory protein family. Plasmodesmata-located proteins (PDLD) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QS54"/>
    <dbReference type="STRING" id="29730.A0A0D2QS54"/>
    <dbReference type="Gramene" id="KJB10030">
        <property type="protein sequence ID" value="KJB10030"/>
        <property type="gene ID" value="B456_001G181200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798414"/>
    <dbReference type="eggNOG" id="ENOG502QWKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FGMVENG"/>
    <dbReference type="OrthoDB" id="1926347at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009506">
        <property type="term" value="C:plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010497">
        <property type="term" value="P:plasmodesmata-mediated intercellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046739">
        <property type="term" value="P:transport of virus in multicellular host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000001">
        <property type="entry name" value="cysteine-rich repeat secretory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000008">
        <property type="entry name" value="cysteine-rich repeat secretory protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051378">
        <property type="entry name" value="Cell2Cell_Antifungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080">
        <property type="entry name" value="ANTIFUNGAL PROTEIN GINKBILOBIN-2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32080:SF36">
        <property type="entry name" value="PLASMODESMATA-LOCATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262031" description="Gnk2-homologous domain-containing protein" evidence="15">
        <location>
            <begin position="32"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="16">
        <location>
            <begin position="35"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="16">
        <location>
            <begin position="143"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB10030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="297" mass="32192" checksum="4CC65CE913C9C4C9" modified="2015-04-29" version="1">MGLPRKSPSLLSLSLVSITIFLGSFPFVATAADYTNLVFKGCADQKFQDPSGVYLQNLKNLMQDLVSQSSQRTFSTAASGEDPNAINGLYQCRGDLSTSQCYSCVSKIPKISDKVCGKAVAARVQLSGCYLRYEIAGFKQVPETEFLYKVCGSSSSGRTEFEKRRETAFNMAEEGVKSGSSLFYTGDYQSVYVLAQCQGDMGTANCGDCVKTAFETAKNNCGDSVSAQLYLHKCYISYSYYPNGIPTISSGTGETRQRTQKTVAIAVGGVAGLGFLVVCLMFLKSVVKKRSKKHEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QUQ9</accession>
    <name>A0A0D2QUQ9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G094400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QUQ9"/>
    <dbReference type="STRING" id="29730.A0A0D2QUQ9"/>
    <dbReference type="Gramene" id="KJB23354">
        <property type="protein sequence ID" value="KJB23354"/>
        <property type="gene ID" value="B456_004G094400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1175">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44378">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 17, PEROXISOMAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44378:SF4">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME 18, PEROXISOMAL ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="4">
        <location>
            <begin position="127"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="207"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB23354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="315" mass="35217" checksum="18D2FA2D40A35252" modified="2015-04-29" version="1">MAKRLGEVGLEDLYRAGGSTISIKEATHMYQAIAASKASDPDPRRVWKEVVSRRVLKPWHPHHLHQLVYYSVYANWDVSINGPPLYWFPSLDESKITNLGRIMEIHGPKLLGTSYKDPIESFSLFQKFSFQHPETYWSIVLEELSVVFHSSPSCILDNSKKLEPSGAWLPGAVLNIAECCLLPSTHPTKEDNSCALVWREEGRDDLDVNRMTLKELREQVMVVANAVDATFSKGDAIAIDMPMTVSAVVIYLGIILAGCVAVSIADSFAAKEIATRLRVSNAKAIFTQDKNVHEEAIIVVLLFIWNPRLVKEKGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QWJ8</accession>
    <name>A0A0D2QWJ8_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="20" type="ORF">B456_007G204000</name>
        <name evidence="21" type="ORF">Gorai_019156</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QWJ8"/>
    <dbReference type="STRING" id="29730.A0A0D2QWJ8"/>
    <dbReference type="Gramene" id="KJB43513">
        <property type="protein sequence ID" value="KJB43513"/>
        <property type="gene ID" value="B456_007G204000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803810"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTNYMED"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000239">
        <property type="entry name" value="Proline-rich receptor-like protein kinase PERK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000207">
        <property type="entry name" value="proline-rich receptor-like protein kinase PERK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047117">
        <property type="entry name" value="PERK1-13-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47982:SF6">
        <property type="entry name" value="PROLINE-RICH RECEPTOR-LIKE PROTEIN KINASE PERK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="259"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="534"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="18"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="579"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB43513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="MBA0590451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="602" mass="64374" checksum="BB35460E3D838525" modified="2015-04-29" version="1">MGSSPENSPSEDSPPAPSDSNSSQDSPSRTDSSSSSSSSSSPRPSSSSSSSPPPPAKSSSSDSKQDSSSSSSSPPPSTRHTYHSPASSNSSHSHKSSGSKQVSSSKNTPSSDSSDKIAGVDIKIIVGAAVAVGLVLLLLIICCIVCCCRKKKKKAQRQVMYYDDAKGDGKDYYNNYQNTQWGNGPNGPEHVVKVPPPSGGANYSGGWGSQAPPVFSGQASSNFSGPHPPPLPPPSPNLALGFNKSTFSYEELLAATNGFSQANLIGQGGFGYVHKGVFPNGKEVAVKSLKSGSGQGEREFQAEVEIISRVHHRHLVSLVGYCIAGGQRMLVYEFVANKTLEHHLHGKDRPVMDFPTRLRIALGSAKGLAYLHEDCHPRIIHRDIKSANILLDNNFEAMVADFGLAKLSTDNYTHVSTRVMGTFGYLAPEYASSGKLTDRSDVFSFGVMLLELITGKQPIDISMDDSLVDWARPLLTRALEGGNVDELVDPRLEKNYNQNEMQRMIACAAASIRHSARKRPKMSQIARILEGDSSLDDLNENGSKPGQSTIFGASGEYTNSSYNADMERFRQLALGSQEFTSSDYGTSSCENSTEMGPGGARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QX05</accession>
    <name>A0A0D2QX05_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G419400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QX05"/>
    <dbReference type="STRING" id="29730.A0A0D2QX05"/>
    <dbReference type="Gramene" id="KJB62492">
        <property type="protein sequence ID" value="KJB62492"/>
        <property type="gene ID" value="B456_009G419400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768129"/>
    <dbReference type="eggNOG" id="ENOG502QVVC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNGCGWT"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB62492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="25895" checksum="5E2E43A6EACF0323" modified="2015-04-29" version="1">MANNNNLEESSPLLSKQVSVEEDEKKNLNVNNSTDVAASPAARTGAGFGWTADGLPLVHGSVVGEPMGRSQWDSSLLACLGRNDEFCSSDVEVCLLGSVAPCVLYGSNVERLGSAPGTFANHCLPYSGLYLIGNSFFGWNCLAPWFSYPTRTAIRRKFNLEGTCEALNRSGGCCGSCLEDEVQREQCESACDFATHVFCHACALCHEGRELRRRLPHPGFNAQPVLVMIPPGEQTMGRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXV4</accession>
    <name>A0A0D2QXV4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G173200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXV4"/>
    <dbReference type="STRING" id="29730.A0A0D2QXV4"/>
    <dbReference type="Gramene" id="KJB12050">
        <property type="protein sequence ID" value="KJB12050"/>
        <property type="gene ID" value="B456_002G173200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785648"/>
    <dbReference type="eggNOG" id="ENOG502QTJ2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFVEWKL"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF1">
        <property type="entry name" value="INACTIVE PEROXYGENASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB12050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22754" checksum="E167A77CF33B1C03" modified="2015-04-29" version="1">MAFSMPPEALLEGVGDAGAAKPSGSEQSVLEKHVAFFDRNHDGIVYPWETFEGFRAIGAGYLLSMTGAFLIHFALSSKTRPGKCPSPFFPIEVKNIHLAKHGSDSGVYDSDGRFISLKFEEIFRKFARTHGNALTSGELMAMLKANREPQDYKGWIGSWTEWMTLYNLCKDNNGLLRKEIVKGVYDGSLFERMERDRKPHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QY73</accession>
    <name>A0A0D2QY73_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small ubiquitin-related modifier</fullName>
            <shortName evidence="9">SUMO</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G442500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="8">Interacts with SAE2, SCE1, SIZ1 and MMS21. Interacts with HSFA2. Covalently attached to ABI5, FLD, GTE3, HSFA2 and ICE1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the ubiquitin family. SUMO subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QY73"/>
    <dbReference type="SMR" id="A0A0D2QY73"/>
    <dbReference type="STRING" id="29730.A0A0D2QY73"/>
    <dbReference type="Gramene" id="KJB62897">
        <property type="protein sequence ID" value="KJB62897"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </feature>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="198" mass="22816" checksum="5A68E28796692853" modified="2015-04-29" version="1">MSSCIKLEVQTDDQTPQKWCISLHEDVLKRLLSQHGGPITMHKVFGEGSLFSPLLFGKFFDPSDAFPLWDFDSDTLLYNLRNSGKTTVDWFHTDQAYVLKAPLPGVGKTNIQIHVEKGKIMEISGQVKQQREGKAKDWRSCNWWLYGYVRRLELPEDADCRKIEAFLTNGVVLEIRIPRNPLYFGTLEMKIQQPKISE</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler B.E."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB24161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G130700"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
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        <property type="term" value="F:ribosome binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:translation elongation factor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="1">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB24161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="116" mass="13381" checksum="0A1FD4DAD57CEDA4" modified="2015-04-29" version="1">MVTIVDGFNYYFCDLLQTIEQTKENVVKKLALTYEEMEQECKETMDGFAEGKDLVVSVMSAMGEGQICALKDIGPKYFQIHLLQILDGTIKDFGSTKCGFDVLFWVWIEKREQQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R509</accession>
    <name>A0A0D2R509_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G3661002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R509"/>
    <dbReference type="Gramene" id="KJB46408">
        <property type="protein sequence ID" value="KJB46408"/>
        <property type="gene ID" value="B456_007G3661002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LLWHANN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="5">
        <location>
            <begin position="195"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="6">
        <location>
            <begin position="331"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="7">
        <location>
            <begin position="815"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB46408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="906" mass="103997" checksum="9ED1CE7D1DC54407" modified="2015-04-29" version="1" fragment="single">IVANIIKSVTHQAPDQNLEMDQLQKQLRDKIDGKKYLLVLDDIWNDDPERWSRLKKLLMGGAKGSRIIVTTRSLRVAEITNKCQSHVLKLKGLSGDDAWSLFKKIAFEQGYADSTNSAFVEVGRQISERCGGVPLAIRTIAGTLSLKKTANEWHSFKENELAKISQIEGEILPILKLSYDHLPSHLKHCFAYCRLYPTDYTIQVQALVQFWIAQGFIKQLNQSQSLEEIGFGYFKDLVERSFFQEVEEYGIGNMTCKMHDLMHDLAESVAGMESSIVDSNKIASDVGEKCRHISINPSLIPLFKGKKLRTLLHFQYGLSQDFSYETWDLIIANCRCLRVLKLNSIGIHKISPSICKLKHLRYLDLSENPVRILPKSICKIQNLLALKLDWCTGLKELPKKIEKLVNLTHLRCKDCWELTHMPRGIGKLTSLETLSMFVVDEDGSHGGADLSELRLLSNLRGELRIRNLGFVKNAKEKFKAANLKEKQHLRSLLLEWSLRFDDDDEKSLEDLQPHPNLKELCIAGWRGKAKFPSWLPLLTNLVKIFISGDNFKYFPSFAQLPCLELLKIERCTKLEYMDDNSLKGSQGEPQSFFPSLKHLSLWDCPNMKSWWRMTKPIDDDSNEDDTTVIGTSTMAFPCLSSLWIVNCPLTLMPLYPSLDDKLELRNTSSRPLKQTIKMNINAKAPSTSTSSLPLSKLKSFHVHNIEGLDTHTLDECLQHLTSLKRLTIGDCKVVDLEGMQWEPLKNLSHLEIDNIPKLVSLPIWLQHLVQLKTLKIHNWNGLRSLLPVFQHLTFLEEFEVRNCEELELSGAGIQIFQDHTSLRSLRLEYIPKCRHLPEWLQHLTNLQRLYLVNLPNLTSLPDEMRCLTSLEYLQVQEIPQLKERCRKDIGADWQKIAHIPDIRLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R884</accession>
    <name>A0A0D2R884_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G025500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R884"/>
    <dbReference type="SMR" id="A0A0D2R884"/>
    <dbReference type="Gramene" id="KJB28074">
        <property type="protein sequence ID" value="KJB28074"/>
        <property type="gene ID" value="B456_005G025500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796469"/>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AYFHYFR"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000167">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000237">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF870">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 75B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="469" mass="52544" checksum="0620FD9E20D129AD" modified="2015-04-29" version="1">MPHPHFIVVTYPAQGHINPTLQFAQHLIRIGVRVTYITSISASRRMTKVPTAEGLSFLPFSDGYDDGIKPGDDIDHYLSEFKRRGKDAISEFITSSENEGKPITCIVYSLCLHWAAEVARKHHIPSALLWIQPATVFDIYYFYFNGYESAIKAQADETNPKCSIKLPGLPPLFTRDLPSFVIASNVYQSALSLFQEQMDVLAEEPNAKILINTFDALEHEALNAIEKFKTVGIGPLVPSSFFNSKDALDNSLRADLFQSDSKNYIQWLDSKPKSAVVYVSFGSMAALKKQQVEEIARALISSRRPFLWVVRNRKDRGEEEKEEDKLTCREELEQFGMVVPWCSQVEVLSHPSLGCFVTHCGWNSTLESLVAGVPVVAFPQWTDQGTSAKLIEDVWGTGVRVSGNEEGIVERDEIVRCLDLVMGDDEKGMEVKKNVEKWKGLAREVAMEGGSMDMNLKAFVDDVAQGYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RB58</accession>
    <name>A0A0D2RB58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_005G080000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RB58"/>
    <dbReference type="STRING" id="29730.A0A0D2RB58"/>
    <dbReference type="Gramene" id="KJB29019">
        <property type="protein sequence ID" value="KJB29019"/>
        <property type="gene ID" value="B456_005G080000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000060">
        <property type="entry name" value="Serine/threonine-protein kinase isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF41">
        <property type="entry name" value="OS12G0163800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="12">
        <location>
            <begin position="187"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="288"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB29019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="553" mass="62332" checksum="40F57DCBE19E4BCD" modified="2015-04-29" version="1">MDLTEGVGESSSPPRSFGSFNSYDVRNDVFNRLVESGHEQAISNPDFRDFLDSHFNRLPASYGLDVNMDRVEDVLLHHKLLALAKDPERRPVYHIRFLENLCTKADAIDDKQYINSLSPQSFDDGDSEKVIPSHKSRSRDHPVDFEPCFKLEDLNLDVRKNSKCEDDIHLTENFTKRQEIVHIPTHEVIFSTTDRPKLLSQLSALLSDIGLNIREAHVFSTTDGYSLSVFVVDGWPVEDTDGLNKAMEKAVARSKGSFPGSSHSPPAIEDASETQEKSGDWEIDGRLLKIGEKIACGSCGDLYRGIYLGQDVAVKILRSEHLNDTLEDEFAQEVAILREVQHRNVVRFIGACTKSPQLSIVTEYMPGGSLYDYLHKNHNVLKLSQLLKFAIDVCKGMEYLHQSHIIHRDLKTANLLMDTDNVVKVADFGVARFLNQGGVMTAETGTYRWMAPEVINHQPYDQKADVFSFAVVLWELVTAKIPYDTMTPLQAALGVRQGLRPELPENAHPKLLDLMQRCWEAAPDMRPSFSEITTELETLFEEVKETTEAVNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFI4</accession>
    <name>A0A0D2RFI4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Cysteine-rich receptor-like protein kinase 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_011G0182002</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFI4"/>
    <dbReference type="Gramene" id="KJB69347">
        <property type="protein sequence ID" value="KJB69347"/>
        <property type="gene ID" value="B456_011G0182002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWDY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FATVEAN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000142">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000012">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000003">
        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32099:SF42">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32099">
        <property type="entry name" value="CYSTEINE-RICH REPEAT SECRETORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 16" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250140" description="Cysteine-rich receptor-like protein kinase 25" evidence="16">
        <location>
            <begin position="27"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="18">
        <location>
            <begin position="139"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="335"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB69347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44980" checksum="3BA26D692967A4C0" modified="2015-04-29" version="1" fragment="single">MQISTVSTNLLLLVIVLSLLSPAIEAQQPTYRFHSCPNTTTFTVNSTYQANRNTVLSSLSSNSTRGDGFYNTTAGRSPDMVYGLFLCRGDLSTSVCQACVTFATTDISQRCPNQTTAVVWYDECLLRYSNQNIFSVVTEEPEVRLRNTQNVTDNQDLFNQQVLAMMNDTANQAANTPEGAKKFATREEDVNFSSTFEALYTLGQCTPDLISMDCNRCLRMVISTLPTGWQGARVLNPSCNVRYEIYPFYNQTGVASPPSPTPSPPAPGGNGRRSWPIIVAIVVPIAASILLLLLMCWLLKRRAKKKYDTNVGYDITTIDSLQYDYATIEAATDKFSDANKLGKGGFGEVYKGILSNQQEIAVKKLSRGSGQGDEEFKNEAVLVAKLQHRNLVRLLGFCLKREERIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RFU2</accession>
    <name>A0A0D2RFU2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G156800</name>
        <name evidence="4" type="ORF">Gorai_016837</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RFU2"/>
    <dbReference type="STRING" id="29730.A0A0D2RFU2"/>
    <dbReference type="Gramene" id="KJB30719">
        <property type="protein sequence ID" value="KJB30719"/>
        <property type="gene ID" value="B456_005G156800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794368"/>
    <dbReference type="eggNOG" id="ENOG502S31C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTYLMPK"/>
    <dbReference type="OrthoDB" id="1072116at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07816">
        <property type="entry name" value="Bet_v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000916">
        <property type="entry name" value="Bet_v_I/MLP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052006">
        <property type="entry name" value="MLP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31338">
        <property type="entry name" value="POLYKETIDE CYCLASE/DEHYDRASE AND LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31338:SF16">
        <property type="entry name" value="POLYKETIDE CYCLASE_DEHYDRASE AND LIPID TRANSPORT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00407">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01037">
        <property type="entry name" value="Bet_v_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bet v I/Major latex protein" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB30719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0586083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="152" mass="17562" checksum="8D8BCF573DB9165F" modified="2015-04-29" version="1">MAQIRRMDCKVEVKSSADRFFDAFNTKAHLMPKMSTRLISDVKLLQGDWNSLGSVRIWYYASQGKSAACKEVRENVDEKNRTIVYGILEGEISNYYKTWKSTLNVTPNGEGSLAKWTIEYEKQNDHVPEPLNYCDFYAIWSKDVDAYLLNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIL0</accession>
    <name>A0A0D2RIL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G102000</name>
        <name evidence="13" type="ORF">Gorai_016427</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
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                <person name="Wendel J.F."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0593226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="555" mass="60244" checksum="9F3BEA75C2DAB7CC" modified="2015-04-29" version="1">MAEESSEFQNTQGLVHAPESNEREIIDRSIFDVGDTSMKPERANKEAYSTYSRVEHKPTRKEIWAWYAYELCSYFVHTVLIPVVFSLTIGQIVEEPTEPLRGWSESAKGLACKINEMKLYERLTQRSISVGNSKVSPLEWTSISWAIGLVLAAPALRSISTNLDQGQNLQVFAGAATAIGALFCLPVGFFKVTWIFPIYIAPVVAAIIVATASHTRHHGLMIRGFSGTTIQRHQFPDRRGVSSWLSLYATAAGCLGSAVIAAFVYYMLRIQDIFTGLWVVSIFSGLKWLAGIVHVFTLRPGEAITSPSPTNHFLSIFKYHHGLGSLIIVGLSSFTSMCIFTGGVLYLVGQLCLKPVFLLYFWLIYFIFPSISLPLLQPIQLVFKANAVKMHLLGLILSLVTSGTGFQFRKENWQRHHILIFAAVQSTSAGVLHAFGRVLLMDCSPAGKEGAFAVWYSWVKMVGTCLGFAIASGAAAGNVGTSFATAFCTAAVAMVISIYANISDVGGAVAAGLVSEEGETASPITKGLDESDSMSMSMSNVDGNAKKQAVGEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RPF1</accession>
    <name>A0A0D2RPF1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G030100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RPF1"/>
    <dbReference type="STRING" id="29730.A0A0D2RPF1"/>
    <dbReference type="Gramene" id="KJB33764">
        <property type="protein sequence ID" value="KJB33764"/>
        <property type="gene ID" value="B456_006G030100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NESMDGC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF122">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB33764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="339" mass="38956" checksum="2708E8971774E0E2" modified="2015-04-29" version="1" fragment="single">KKCAACFREFNKMEHLVDHMRTSYHSLHEPTCVLCNKHCRSFDSLREHLIGPLPKQECNKLFKILGCKFCLSILESPHALKLHQHRCRFSGVNYGTMSRPANKSTTVVDNGFSSHVVALACQMVDGGGNNESMDGCARVCMVDEYENIIFHVYVKPPISVPNYRYENSGIGGEHLRDGMPLKQVQRRIEEFLCNGEAMWKIRSPKAGKARILVGHHLHPLLQSLHLQYPSFMIRDTAAYPPLMKTNKLSNSLKYLTQTYLGYDIQAGVQDPYEDCVATMRLYLRMRNQVHQREDYPQASDPRNRNNFAPSRQSELERMSPEAMLAISRSDYYCWCLDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RYL4</accession>
    <name>A0A0D2RYL4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G073300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYL4"/>
    <dbReference type="STRING" id="29730.A0A0D2RYL4"/>
    <dbReference type="Gramene" id="KJB34571">
        <property type="protein sequence ID" value="KJB34571"/>
        <property type="gene ID" value="B456_006G073300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WFMVPEA"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000010">
        <property type="entry name" value="3-isopropylmalate dehydratase large subunit, chloroplastic-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001614">
        <property type="entry name" value="PRK00402.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF11">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="73"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="6">
        <location>
            <begin position="362"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB34571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="510" mass="55404" checksum="11AF75253619E47D" modified="2015-04-29" version="1">MASSVGFAHPTSSLIINKKDKSLSVVPSTSQLSIYKCKKPISNNISMAMATRQSERKPATTGSMKSPMTMTEKILAKGAEKAEVKAGDNVWVNVDVFMTNDISGPGSIGIFQKEFGENAKVWDREKVVVIPDHYIFTSDERANRNVDILREFSLDQNIKYFYDITDLSNFKANPDYKGVCHIALAQEGHCRPGEILLGTDSHTCTAGAFGQFATGIGNTEAGFVLGTGALLLKVPQTLRFVMNGEMPDYLLAKDLILQIIGEISVAGATYKSMEFVGTTVESLNMEERMTLCNMVIEAGGKNGVVAADSTTFKYLEDKTSVPYEPVYSDGLASFHSEFRFDISKLEPLVAKPHSPDNRALARECKHIKIDRVYIGSCTGGKTQDFLAAAKLFLASGKKVKVPTFLVPATQKVWVDIYTLIVPGSGGKTCSQIFEEAGCDTPASPSCAACMGGPKDTYARMNEAQVCVSTTNRNFPGRMGHKEGQIYLASPYTAAASALTGYITDPREFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RZP7</accession>
    <name>A0A0D2RZP7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pectate lyase superfamily protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G147300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RZP7"/>
    <dbReference type="STRING" id="29730.A0A0D2RZP7"/>
    <dbReference type="Gramene" id="KJB24490">
        <property type="protein sequence ID" value="KJB24490"/>
        <property type="gene ID" value="B456_004G147300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTPQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051801">
        <property type="entry name" value="GH28_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339">
        <property type="entry name" value="PECTIN LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31339:SF9">
        <property type="entry name" value="PLASMIN AND FIBRONECTIN-BINDING PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB24490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="52118" checksum="CFF68C9275B7B989" modified="2015-04-29" version="1">MECCRQLVVLVDVLLVLAFCGHIAWTVKASSQCKQALSREIRPHSVAITEFGAVGDGVTLNTKAFQNAIFYLNSFSDKGGAKLFVPAGRWLTGSFDLISHLTLWLDKDAVILGSDNPDDWPVVDPLPSYGRGVELPGGRHRSLIYGRNLTDVIITGDNGTIDGQGSVWWNWFKRKTLDYTRPHLVELMNSTGVVISNLTFSNSPFWTIHPVYCSHVIVQNVTILAPLDSPNTDGINPDSSNDVCIEDCYISTGDDLIAIKSGWDEYGISFARPSTNIIIRRLIGHNRNGSGIAIGSEMSGGVSEVYAENLYFFDSSTAITIKTARGRGGYVRNIYILNVTLVGVDTAIRFDSTFSPHPDDFYDPNALPVIERITIKDVIGNNIKVAGLLEGIEGDTFHHVCLLNIALTVTSGSPWNCSYIQGYSAMVSPETCEPLKESIYPNHSSDCYHLSNHLRSSVGILILAISQAQQQPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2Q2</accession>
    <name>A0A0D2S2Q2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G263500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the targeting and/or fusion of transport vesicles to their target membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S2Q2"/>
    <dbReference type="STRING" id="29730.A0A0D2S2Q2"/>
    <dbReference type="Gramene" id="KJB38624">
        <property type="protein sequence ID" value="KJB38624"/>
        <property type="gene ID" value="B456_006G263500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800756"/>
    <dbReference type="eggNOG" id="KOG0859">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTHAQEF"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000009">
        <property type="entry name" value="Vesicle-associated membrane protein 724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF72">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="11">
        <location>
            <begin position="10"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="130"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB38624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25139" checksum="EE330AD9C10B7DD0" modified="2015-04-29" version="1">MSQEAFIYSFVARGTTILAEYTEFTGNFPAIAAQCLQKLTSSNNKFTYNCDHHTFNFLVEDGYVYCVVAKDSVGKQISISFLERMKVDFKKRYGGGKADTAMAKSLNKEFGPVLKEHKKYIIEHAEEIEKLLKVKAQVSEVKSIMLENIDKAIDRGESLTTLADKTENLHDQAQAYKNQGTKIRRKMWYQNMKIKMVVLGILLLLVLVIWVSVCHGFDCSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3T9</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 7"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="96" mass="10846" checksum="FCF3F0AAD32910F2" modified="2015-04-29" version="1">MSVIFRPSCTLPFPISFSFRRIMSILFSLSLTISVFCRSSCRGSLPARDSWPCVPRFSSGCPHSLSSWRRLHHGSPLNGARWNPNLFATAGCSYFW</sequence>
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    <accession>A0A0D2S455</accession>
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        <lineage>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB26050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="KEGG" id="gra:105793695"/>
    <dbReference type="eggNOG" id="ENOG502S1IN">
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="entry name" value="cupin_TM1112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008579">
        <property type="entry name" value="UGlyAH_Cupin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33271">
        <property type="entry name" value="OS04G0445200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33271:SF3">
        <property type="entry name" value="RMLC-LIKE CUPINS SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05899">
        <property type="entry name" value="Cupin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="(S)-ureidoglycine aminohydrolase cupin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB26050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="110" mass="12256" checksum="358C97783C27C6A3" modified="2015-04-29" version="1">MAENSLRIFVEKNPSDSKLSELNIKCWPKWGCSPGKYQLKFDAEETCYLLKGKVRVYPKASLSTSTAEMVEFGAGDLVIIPKGLSCIWDVSIAVDKHYQFQSSSSSSCDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S6S4</accession>
    <name>A0A0D2S6S4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ZF-HD dimerization-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_009G231800</name>
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    <organism evidence="12 13">
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S6S4"/>
    <dbReference type="Gramene" id="KJB58948">
        <property type="protein sequence ID" value="KJB58948"/>
        <property type="gene ID" value="B456_009G231800"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QRG0">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="1921929at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000257">
        <property type="entry name" value="Zinc-finger homeodomain protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006455">
        <property type="entry name" value="Homeodomain_ZF_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006456">
        <property type="entry name" value="ZF_HD_homeobox_Cys/His_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01565">
        <property type="entry name" value="homeo_ZF_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01566">
        <property type="entry name" value="ZF_HD_prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31948:SF140">
        <property type="entry name" value="ZINC-FINGER HOMEODOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04770">
        <property type="entry name" value="ZF-HD_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51523">
        <property type="entry name" value="ZF_HD_DIMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZF-HD dimerization-type" evidence="11">
        <location>
            <begin position="59"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="165"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB58948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="255" mass="27536" checksum="E6F7876DADCFD511" modified="2015-04-29" version="1">MDFEEHDDQDEEMGMAVPAGYDSLGNSSAPRSKIGPAASGGEGAAASAPPRKVGSGIRYRECQKNHAVSIGGHALDGCGEFMAAGDEGTLDALKCAACNCHRNFHRKETDGEGSSIYNPHHHHHHYQQHPQFSPYYRAPPPAGYLHLTPQQRPLALPAASGGGIAGGYSREDEDVSNPSSSAGGGGGSGGLKKRFRTKFTPEQKDKMLGFAERLGWRIQKHDEAAVEQFCEETGVKRQVLKVWMHNNKYTLGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S938</accession>
    <name>A0A0D2S938_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanosine nucleotide diphosphate dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G055600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S938"/>
    <dbReference type="SMR" id="A0A0D2S938"/>
    <dbReference type="STRING" id="29730.A0A0D2S938"/>
    <dbReference type="Gramene" id="KJB79587">
        <property type="protein sequence ID" value="KJB79587"/>
        <property type="gene ID" value="B456_013G055600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782574"/>
    <dbReference type="eggNOG" id="KOG1439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADHCFIS"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000010">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.519.10:FF:000015">
        <property type="entry name" value="Guanosine nucleotide diphosphate dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF10">
        <property type="entry name" value="GUANOSINE NUCLEOTIDE DIPHOSPHATE DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB79587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="444" mass="49593" checksum="8F5EF5CF32B507F2" modified="2015-04-29" version="1">MDETYDVIVLGTGLKECILSGLLSVDGLKVLHMDRNDYYGGESTSLNLVQLWKHFKGNDKPPEQLGTSREYNVDMIPKFMMANGSLVRILIHTGVTKYLNFKAVDGSYVYKKKKIYKVPATDVEALKSPLMGLFEKRRARKFFIYVQDYDENDPKSHEKLDLNKVTAKELISKYGLEDDTIDFIGHALALHNEDSYLAQPALNFVKRMKLYAESLARFQGGSPYIYPLYGLGELPQAFARLSAVYGGTYMLNKPECKVEFDGDGKVIGVTSEGETAKCNKVVCDPSYLSDKVKKVGKVARAVCVMSHPIPDTNDSHSAQVILPQKQLGRKSDMYVFCCSYAHNVAPKGKYIAFVSAEAETDNPEQELKPGVDLLGSVDEIFYDTYDRYVPTNDHQADNCFISASYDSTTHFETTVIDVMEMYTKITGKVLDLSVDLSAASAAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SC45</accession>
    <name>A0A0D2SC45_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G071000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SC45"/>
    <dbReference type="STRING" id="29730.A0A0D2SC45"/>
    <dbReference type="Gramene" id="KJB28820">
        <property type="protein sequence ID" value="KJB28820"/>
        <property type="gene ID" value="B456_005G071000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2352">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="AdoMet_MTases"/>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
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        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
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        <property type="entry name" value="Methyltransf_11"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
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    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
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        <location>
            <begin position="53"/>
            <end position="155"/>
        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="EMBL" id="KJB28820.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
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                <person name="Reddy U.K."/>
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                <person name="Saranga Y."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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    <accession>A0A0D2SCN2</accession>
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            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJB39561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0588980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB39561"/>
        <property type="gene ID" value="B456_007G019300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2569">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="CAND6-7_N"/>
    </dbReference>
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        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF22">
        <property type="entry name" value="DBJ|BAA84809.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21904">
        <property type="entry name" value="CAND6-7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036292369" description="Intimal thickness related receptor IRP domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
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    </feature>
    <feature type="domain" description="CAND6/7 N-terminal" evidence="9">
        <location>
            <begin position="26"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="8">
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            <begin position="169"/>
            <end position="409"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
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        <source>
            <dbReference type="Pfam" id="PF21904"/>
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    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB39561.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0588980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="50323" checksum="FC4AB79FE0FA9A73" modified="2015-04-29" version="1">MCRSFLLFLLISLFVSFGFAEIRFTKIRSNDRPIIPFDEFWFTHNGRLELNVSQITLSDNNPNLNFNNVGFFLCTRNAWLHVLQQLADAEISCVLHSSLVKIVSNFKTLNGKSSFNSVLPVKNADRYTLLFANCLSQVKVSMTVRSAMYNLKGNQNHRDYLSADETFLPKLYFLLSLVYFTLAGIWIYVLYKKRLTVFRIHFFMLIVVVLKALNLVSKAEDTLYIQQTGTAHGWDVPFYIFSSLKGIMLFTLIILIGTGWSLLKPYLQDKEKMVLTIVIPLQVVANIALVIIDETSPFSPYRVTWKSLFLLVDIICCCAMLLQIIWSIKNLREAAQTDGKAAVNLMKLTLFKQYYVMVICYIYLTLVAVYGLETITWGKYPWSCVLVGELATLVFYVFTGYKFKPETYNPYFAIDDEEEEADDVEQLKLHDEEKIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SD99</accession>
    <name>A0A0D2SD99_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G032700</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SD99"/>
    <dbReference type="Gramene" id="KJB39831">
        <property type="protein sequence ID" value="KJB39831"/>
        <property type="gene ID" value="B456_007G032700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QITTQID"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000187">
        <property type="entry name" value="E3 ubiquitin-protein ligase ATL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044600">
        <property type="entry name" value="ATL1/ATL16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46913:SF1">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="33"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="120"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB39831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="220" mass="25340" checksum="06BB1D60084ED1D1" modified="2015-04-29" version="1">MSNGLDPELIQAFPTFYYSTVKEFRREKYGLECAICLGEFNDNDMLRLLTICCHVFHKECVDLWLESHKTCPFCRGELDEPRQSLDKSPMIVRSNSMHEIGASQSPLQDAVCIDIREDDDDKDTVGERENEAQTSSNTNQEHSRIQKFSRWNSTGHSIPRTREEDRYTLRLPEHIKKQFVRGHKIAKSCITFGEFTSPSDYRNQGSGKPSETLQGDIDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SEX3</accession>
    <name>A0A0D2SEX3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome non-ATPase regulatory subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G375500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SEX3"/>
    <dbReference type="STRING" id="29730.A0A0D2SEX3"/>
    <dbReference type="Gramene" id="KJB61703">
        <property type="protein sequence ID" value="KJB61703"/>
        <property type="gene ID" value="B456_009G375500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766425"/>
    <dbReference type="eggNOG" id="KOG4413">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WGQEYIS"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB61703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="56987" checksum="E5E45889FBC5D5D3" modified="2015-04-29" version="1">MDEEFALDDPTQLLDSASDFAHHPGSLNDAAVKDFLDRFPLPVIISALQTKSDVPGLENTLVACLERVFKTKYGASLIPQYMTFVQVGLKADSQVVRCLSCKTVSSFLKNFDDKSIYAIKLIIDCDIYQLLLDCLINGDEQVATAAIDAIKNLAQFPEAVGIIFPSNINEATHLGNVASRCSSLGRVRVLSLIVKLFSISSSIASVIYNSNLLSLLEAEIRNSNDTLVTLSALELLYELTEVQHGAEFLARTTLQLLHSIISNSSMESILRSRALMISGRLLSKENVYMFVDEPSAKSLISAIDVRLGLLDSQDTDERESALEALGGIGSSIQGAVLLLTSFPPAARHIVHAAFDRQGGGKQLAALHALGNIVGENRPEDGVILNGDAEESLRRLVYEVASESSKLTPSGLLLSVLQQAAEFRLAGYRVITGLVARVWCLMEIFSKPEIINIVTDPTAETTKIAMEARYNCCKAIHRSFMSSKLVSDPALSGIAGKLQEAVQRGPYLVRKHTEATPVVMTAERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SFR7</accession>
    <name>A0A0D2SFR7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G172900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SFR7"/>
    <dbReference type="Gramene" id="KJB82012">
        <property type="protein sequence ID" value="KJB82012"/>
        <property type="gene ID" value="B456_013G172900"/>
    </dbReference>
    <dbReference type="OMA" id="ECLIAGY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021:SF7">
        <property type="entry name" value="PROTEIN FB17, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="305" mass="34706" checksum="1638149A6FB2BA91" modified="2015-04-29" version="1">MAFKPEWVTQPIFSGLIFSIFYLIFVNLLKNLNPGLQYFDLQSNWNFQKEFESFTAENGKLEDLIEYLIAGYRQVPATDLQKQEISVDLSYSHPNFDVKLDGIELDDLKDDLVPSKVTNPENSLIIQPNTITEFLLKIDEDVASNVDLSDFTICFNGEQKTIGRYSFPISLVPTVERIMNAYGDVSASSPMNTNITGKIYLLFCATIKEMEDLELHQVTQTKMLKWRDAIKDALRVKFKVEFAMSHLKKIARAYFGGIGEQVLLTINEKLNSLYKERAKALEGFKDFLANAKDFDGQSVSTGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJB1</accession>
    <name>A0A0D2SJB1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_005G183600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the splicing factor SR family. RSZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJB1"/>
    <dbReference type="STRING" id="29730.A0A0D2SJB1"/>
    <dbReference type="Gramene" id="KJB31255">
        <property type="protein sequence ID" value="KJB31255"/>
        <property type="gene ID" value="B456_005G183600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0107">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12373">
        <property type="entry name" value="RRM_SRSF3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000214">
        <property type="entry name" value="Serine/arginine-rich splicing factor 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23569" checksum="D4203093E8528719" modified="2015-04-29" version="1">MSRVYVGNLDPRVTERDLEDEFRIFGVLRSVWVARRPPGYAFIEFDDRRDAIDAIRELDGKNGWRVELSHNSKGGGGRGGRRGGGEDLKCYECGEPGHFARECRSRYGSRGLGSGRRRSPSPRRRRSPSYGYGRRWAIVQEDLLGAAAYHLVVVGVTAGRLHIVILVVIHLMQMEIKVGTEAKSEMTASMANKYSNTIVLNRFSEQKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SLK8</accession>
    <name>A0A0D2SLK8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G289900</name>
        <name evidence="3" type="ORF">Gorai_019738</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLK8"/>
    <dbReference type="STRING" id="29730.A0A0D2SLK8"/>
    <dbReference type="Gramene" id="KJB45094">
        <property type="protein sequence ID" value="KJB45094"/>
        <property type="gene ID" value="B456_007G289900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804775"/>
    <dbReference type="eggNOG" id="ENOG502S81K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGFWGFV"/>
    <dbReference type="OrthoDB" id="1930127at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132">
        <property type="entry name" value="EMB|CAB87627.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132:SF2">
        <property type="entry name" value="EMB|CAB87627.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989234" description="Methyltransferase-related protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB45094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0591050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10304" checksum="840F4BD4BF9A0956" modified="2015-04-29" version="1">MCPMRFLLVFFSAILAGYFAWRTVRSSSDIDGQVSEDSEKIIVKDKQEFSFKRMVQNGFWVFVDMASGKYLWRNFKELKNDKKMKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNH6</accession>
    <name>A0A0D2SNH6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G324500</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNH6"/>
    <dbReference type="STRING" id="29730.A0A0D2SNH6"/>
    <dbReference type="Gramene" id="KJB45739">
        <property type="protein sequence ID" value="KJB45739"/>
        <property type="gene ID" value="B456_007G324500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAKYCTL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004:SF439">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB45739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56089" checksum="BA988F21864202FA" modified="2015-04-29" version="1">MSHITKCSINSIKNINFNCSNTYNFRRSIISYQNNAFRHYFNDTDLIHLGLILSRRLSFFLTNLTIGLSLSLELLPQLSSPLNSNRPTRQIPTPPPSLLWYFASRNKLVGDIPSSICNSSSLKVLSLWNNSFNGTIPECIGNLSSSLSHIDLWNNNFHGKIPESFAKYCTLQSFRINNNQIGGSLPRSLGNCKDLNLLDVGNNKLNDTFPNWLGNLDHLQVLVLRSNKFFGQMDNSDVTVSFSRLRIIDLSRNNFSGYLPTNFFKNLHSVRKGHENKLEPEYMEDVSDYVAFNFAYGLSFTVKGSATEFQSLLTKWMVIDFSDNQFFGELPKTLGELHSLIIVNLSHNCLTGPIPSSLGDLSELESLDLSSNKFQGRIPTELTNLGFLEVLNLSQNNLEGPIPQGKQFDTFTNDSYKENLGLCGLPLSKRCDNYRGTLVKFDRDDDELNWKFSILMGYGCGLVLGLSMGYIVFATGKPWWLIRIVERVQQRFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SUJ2</accession>
    <name>A0A0D2SUJ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">gibberellin 2beta-dioxygenase</fullName>
            <ecNumber evidence="10">1.14.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_006G092800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the 2-beta-hydroxylation of several biologically active gibberellins, leading to the homeostatic regulation of their endogenous level. Catabolism of gibberellins (GAs) plays a central role in plant development. Converts GA9/GA20 to GA51/GA29 and GA4/GA1 to GA34/GA8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>gibberellin A1 + 2-oxoglutarate + O2 = gibberellin A8 + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15005"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:58524"/>
            <dbReference type="ChEBI" id="CHEBI:58594"/>
            <dbReference type="EC" id="1.14.11.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Hormone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Plant hormone biosynthesis; gibberellin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the iron/ascorbate-dependent oxidoreductase family. GA2OX subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.13" evidence="10"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SUJ2"/>
    <dbReference type="STRING" id="29730.A0A0D2SUJ2"/>
    <dbReference type="Gramene" id="KJB34965">
        <property type="protein sequence ID" value="KJB34965"/>
        <property type="gene ID" value="B456_006G092800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797904"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NLCLESH"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045543">
        <property type="term" value="F:gibberellin 2-beta-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000014">
        <property type="entry name" value="Gibberellin 2-beta-dioxygenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="2 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="165"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00052204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB34965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="325" mass="36349" checksum="D4868C21AF4F3802" modified="2015-04-29" version="1">MVVLSKPAPLHDHYASIKTCKPRISVFKGIPSINLRDPKAKMLIIQACQEFGFFKLLNHGVPMETIARLEAEALSFFNLPRSVKDKAGPPNPFGYGTKGIGPNGDVGWIEYLLINTDQNPAISRSAVKDYVMEVKAVAYEVAELMAEGLGIERRDVWSKMLREEESDWCLRLNHYPISQDLQALSGRKMIGFGEHTDPQIISLLKSNNTSGLQICLKDGTWVSVPPDHASFFVTVGDALQVMTNGRLKSVRHRVMTNSLKPRISMIYFGGPPLSETIRPLPSLMAKGEESLYNEFTWREYKASAYKSRLGDYRLGLFEKASTTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SWA2</accession>
    <name>A0A0D2SWA2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G068900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SWA2"/>
    <dbReference type="Gramene" id="KJB48429">
        <property type="protein sequence ID" value="KJB48429"/>
        <property type="gene ID" value="B456_008G068900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB48434">
        <property type="protein sequence ID" value="KJB48434"/>
        <property type="gene ID" value="B456_008G068900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763291"/>
    <dbReference type="eggNOG" id="ENOG502QVYY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WNGSHAG"/>
    <dbReference type="OrthoDB" id="1642657at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000063">
        <property type="entry name" value="G-box binding factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044827">
        <property type="entry name" value="GBF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012900">
        <property type="entry name" value="MFMR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967:SF20">
        <property type="entry name" value="G-BOX-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45967">
        <property type="entry name" value="G-BOX-BINDING FACTOR 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07777">
        <property type="entry name" value="MFMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="247"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB48434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="344" mass="36154" checksum="8F3A20C7230B7415" modified="2015-04-29" version="1">MGTEEESTPAKPSKPTASTQEMPTTVSYPDWSTQMQAYYGAAATPPLFASTVASPTPHPYIWGGQHPLMPPYGTPVPYPAVYPPRGVYAHPNMAPMPSSARNNGADGKDRGATKKPKGSSGSKVGESAKATSGSGNDGGSQSGESGSEGTSDRSDESNQQEVNAGKKGSFEQMLADANAQGKAAGALVPAEPIVSMPATTLNIGMDLWSASPAATGAPKTRPNASGTVATVPAGAVMPDQWIQDERELKRQKRKQSNRESARRSRLRKQAECEELQAKVESLANENHTLRDELKKLSDECEKLTSENSSIKDELMRICGPEAISNLEQGNPSPVGEAGGDEGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1B3</accession>
    <name>A0A0D2T1B3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G062500</name>
        <name evidence="5" type="ORF">Gorai_008983</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0591994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1B3"/>
    <dbReference type="STRING" id="29730.A0A0D2T1B3"/>
    <dbReference type="Gramene" id="KJB48291">
        <property type="protein sequence ID" value="KJB48291"/>
        <property type="gene ID" value="B456_008G062500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763217"/>
    <dbReference type="eggNOG" id="KOG3070">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HMAKDCV"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF22">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="149"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB48291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0591994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="244" mass="25621" checksum="BA94C212367C04BE" modified="2015-04-29" version="1">MAEQQQEQQQSRSTGKVLWFDDQKGFGFIHPDDGGEDLFVHQSSIKSEGYRSLAEGESVEFTVSQGNGGKTQAVDVTAIGGSQISKKDRRTGGGGWRAGNDRRNGSGGCYNCGDLNHLARDCSNNLISLDNNDNYNNSAYNSGGGGGSCYNCGEAGHFARECRRDAGGSAGGGAGKCYNCGKFGHFARECNRNSGAGGGSRGCFNCGGFGHLARDCSNNKGSECYKCGEAGHFARECPNLKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7X2</accession>
    <name>A0A0D2T7X2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pterin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_008G176100</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate = 7,8-dihydropteroate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19949"/>
            <dbReference type="ChEBI" id="CHEBI:17836"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="EC" id="2.5.1.15"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="ChEBI" id="CHEBI:72950"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the DHPS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T7X2"/>
    <dbReference type="STRING" id="29730.A0A0D2T7X2"/>
    <dbReference type="Gramene" id="KJB50551">
        <property type="protein sequence ID" value="KJB50551"/>
        <property type="gene ID" value="B456_008G176100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764458"/>
    <dbReference type="eggNOG" id="KOG2544">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMYETEP"/>
    <dbReference type="OrthoDB" id="615426at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.20:FF:000006">
        <property type="entry name" value="Dihydropteroate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.560:FF:000003">
        <property type="entry name" value="Folate synthesis bifunctional protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="entry name" value="7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="entry name" value="Dihydropteroate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="FOLATE SYNTHESIS PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941:SF1">
        <property type="entry name" value="FOLIC ACID SYNTHESIS PROTEIN FOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="Dihydropteroate synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00794">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="16">
        <location>
            <begin position="230"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB50551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="511" mass="56080" checksum="69EE9506349C41F8" modified="2015-04-29" version="1">MNLFKKLLSTKHGIIGAQKYCRATFCSILHSAVDHSVEVHSPDQEVVIALGSNVGDRLNNFNQALQLMRKSGIHITKHGCLYETAPAYVTDQPRFLNSAVRAVTKLGPHELLGVLKTIERNMGRSGGIRYGPRPIDLDILFYGKYQIGSDKLTVPHERIWERPFVMAPLMDLLGLVIDSDTVACWHSLSTDSDGLFGLWDKLGGESLIGKEGMKRVLPIRNHLWEWSKKTSVMGILNLTPDSFSDGGKFVSVQNAVSHVRSMISEGADIIDIGAQSTRPMASRISAEEELDRLIPVLEAVLEMPEMEEKLVSVDTFYSDVASEAVKKGAHLVNDVSAGQLDPNMLKMVASLDVPYIAMHMRGDPTTMQSRDNLQYSDVCSQVASELFSRVKDAELSGVPAWRIILDPGIGFSKKTEHNLDILTGLPVIRSEIAKRSLAASHAPLLIGPSRKRFLGEICNRPAAGERDPATIASVTAGIFGGANIVRVHNVRDNVDAVKVCDAMLKERSIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T895</accession>
    <name>A0A0D2T895_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G182700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T895"/>
    <dbReference type="SMR" id="A0A0D2T895"/>
    <dbReference type="STRING" id="29730.A0A0D2T895"/>
    <dbReference type="Gramene" id="KJB50696">
        <property type="protein sequence ID" value="KJB50696"/>
        <property type="gene ID" value="B456_008G182700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764532"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GCQMAYE"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009617">
        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000003">
        <property type="entry name" value="Outer mitochondrial membrane protein porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00558">
        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB50696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="276" mass="29399" checksum="06F71F2C59640603" modified="2015-04-29" version="1">MGKGPGLYTDIGKKARDLLYKDYQADHKFTLTTYTSNGVAITSTGTKKGELLLADISTELKNKNITTNVKVDTSSKLFATVTVDEPAPGLKTIFSFIAPDQRSGKVELQYQHEYAGISTSIGLTANPLVNFSGVVGNNSVTVGTDLSFDTASGNFTKLNAGLNFTHSDLIASLTLNDKGDTLNASYYHIVSPLTNTAVGAELSHSFSSNENTLTIGTQHALDPLTTVKARLNNYGRASALIQHEWRPKSLITISGEVDTGAIEKSAKVGLALALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8R5</accession>
    <name>A0A0D2T8R5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NIF system FeS cluster assembly NifU C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G162800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72058.1"/>
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        <property type="gene ID" value="B456_011G162800"/>
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    </dbReference>
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        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="OS09G0481800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36018:SF1">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB72058.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="19316" checksum="DBB3A79AA59D1547" modified="2015-04-29" version="1">MSKDLLVSHCYYQSKTMVASTAAVTFPGPGGLISGRARPRSRPAGVKLQQQRPSSINIHIISRISSQSKSLGPLKAASGGGVPLPPLDLTEENIELVLADARVELAQLFDTEVGITGQVELSELDGPFVKISLKGRFWHKRTTVVARVGNYLKQRIPEILVVEIEDEKQLDDSPENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T932</accession>
    <name>A0A0D2T932_GOSRA</name>
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            <fullName evidence="5">Thaumatin-like protein 1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">B456_007G048800</name>
    </gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB40150"/>
        <property type="gene ID" value="B456_007G048800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801428"/>
    <dbReference type="eggNOG" id="ENOG502QUID">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SGRLWCQ"/>
    <dbReference type="OrthoDB" id="1714438at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002267722" description="Thaumatin-like protein 1" evidence="2">
        <location>
            <begin position="26"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB40150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="18573" checksum="7E7CC5ED33C9A63A" modified="2015-04-29" version="1">MTTHQLSIVLAMFFLQLFLSSQSHSSVFTMVNKCRYTVWPGVLSGAGTTQSSPTGFILRRGESTSVSVPTSWSGRLWCQTLCTEDSSGKFSCLTGDCGSSTLECSSSGASPPATLAEFTLNGAGEVDFYDVSLVDGYNLPMMVSPNGGTGGNRTLAFIGGAITILAAMRQLWHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB81</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB72973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_011G2068002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB72973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="24091" checksum="0557FAF5239270FE" modified="2015-04-29" version="1" fragment="single">ELQIDELHTTSQSSSDENEPSINMLIKYQEFMIKVIDKIQDLELKREYILKLKSSLKEKPEKEKEIIYSQSQMYNIQDIIFNKYEKIKPRQITNSKLQLEIKQIKLELSQLKTEQQEMKGQMRSLKHEIAEKSSSETEPEPEENTQEYIMILTEILPNAEISNKGIKYQTCFLMVKDITQDVILGTPFISLLKHYKVTNNSISTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TBX2</accession>
    <name>A0A0D2TBX2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G224000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TBX2"/>
    <dbReference type="STRING" id="29730.A0A0D2TBX2"/>
    <dbReference type="Gramene" id="KJB73228">
        <property type="protein sequence ID" value="KJB73228"/>
        <property type="gene ID" value="B456_011G224000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776592"/>
    <dbReference type="eggNOG" id="ENOG502QSJE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FNILCQE"/>
    <dbReference type="OrthoDB" id="1927586at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF160">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="8">
        <location>
            <begin position="548"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB73228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="858" mass="96565" checksum="2298329EE0DD26F7" modified="2015-04-29" version="1">MDVGGGKGDNVRGVNIESSKGGGSSGNLIENLTGIDVVVNPNDDGGAGGKPCVGMEFESEDAGRTFYDGYARRLGFSTHVGQFTRTKLDGPIVTWDFACSREVLKRKNVESCNAMFRIERKDGKKWVATKFVEDHNHSMVNPSKVHYLRPRRHFAGVTKNVPETSDAATDVWALVDGNHVSCEATRVGNTSCVDPNHLVRNMGSVGYVGLPSQRRTLGKDAQNLLNYFKKLQAENPGFYYAIQLDDDNRMTNVFWADARSRAAYNHFGDAVIFDTMYRPNQYQIPFAPFTGINHHGQMVLFGCALLLDESESSFTWLFRTWLSAMNNRCPVSITTDQDRAIQAAVSQVFPETRHCICKWHILREGQERLAHIYLAHPSLYGEIYGCINFSETIEDFESSWTTLLDKYNLQKNEWLLAVYNARKQWAPVYFRGTFFAILSSNQGVSSFFDGYINQQTTIPLFLKQYERALECSLEKEIEADCDTICTTPELKTPSPMEQQAANLYTKKVFSKFQEELVETFVYTANKIEGDGIVSKYRVAKYEHDDKAYFVMLNVSEMKASCTCQMFEYSGILCRHILTVFTVTNVLTLPSHYILRRWTKSAKSWVGLDEKNADPQGVETLTARFNILCQEAFKLAEEGSVVPETYSAAINALRDAVKKVAFIKKDVAKVTPPRSYINGNSHEDGSKKTTSPVSEMVPSLWPWQDVVSPRFNLIDSGAPLTDLNQPSMAPVSIDRETDHLDSTVVLSCFKSMTWVIENKKEVEACKVAVINLKLHDYSKNPLGEAEVQFSLTKVTLEPMLRSMAYISQQLSTPVNRVAAINLKLQDTKTTSGEKEVKFQVSKDTLGSMLRSMAYIREQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TD78</accession>
    <name>A0A0D2TD78_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G244800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TD78"/>
    <dbReference type="Gramene" id="KJB73703">
        <property type="protein sequence ID" value="KJB73703"/>
        <property type="gene ID" value="B456_011G244800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB73703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="11798" checksum="84BC39A4B42466BC" modified="2015-04-29" version="1" fragment="single">MVDLLSTLKIFYVLHLNLRPLPEEIPIDSKATIKAKSTNTTNHAEQYTKKPIVMVAKMQIRMEIEAHMATAIKSSKWWLDSRDNSRHVKNVKTILDPNEELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TEP1</accession>
    <name>A0A0D2TEP1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G063000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TEP1"/>
    <dbReference type="Gramene" id="KJB55089">
        <property type="protein sequence ID" value="KJB55089"/>
        <property type="gene ID" value="B456_009G063000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768373"/>
    <dbReference type="eggNOG" id="KOG1278">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEYEGNW"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF110">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354300" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="31"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="495"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="605"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB55089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="644" mass="74134" checksum="BCB6691498EDB76E" modified="2015-04-29" version="1">MEYRSRSIHKSTSIMISAILFLFLIHTSHCFYLPGVAPEDFQKGDPLKVKVNKLTSIKTQLPYSYYSLPFCPPKKIVDSAENLGEVLRGDRIENSPYVFKMREPQMCSVLCRITLDAKAAKQFQEKIDDEYRVNMILDNLPLVVPIRRLDQGSPTVYQLGYHVGLKGQYTGSKEEKIFIHNHLAFTVKYHRDPQTDSARIVGFEVKPYSIKHEYEGKWSENTRLTTCDPHTKHTVVNSNTPQEVEANKEIIFTYDVEYQESDVKWASRWDAYLLMSDDQIHWFSIVNSLMIVLFLSGMVAMIMLRTLYRDISKYNELETQEEAQEETGWKLVHGDVFRPPSNSDLLCVYVGTGIQFLGMVLVTMIFAVFGFLSPSNRGGLMTAMLLLWVFMGIFAGYASSRLYKMFKGTEWKKISLKTACLFPGIVFAIFFVLNALIWGQKSSGAVPFGTMFALVVMWFGISVPLVFVGGYIGFKKPAIEDPVKTNKIPRQIPEQAWYMNPIFSILIGGILPFGAVFIELFFILTSIWLNQFYYIFGFLFLVFIILLITCAEITIVLCYFQLCSEDYLWWWRSYLTSGSSALYLFLYATFYFFTKLEITKLVSGMLYFGYMLIASYAFFVLTGTIGFYACFWFTRLIYSSVKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TFY4</accession>
    <name>A0A0D2TFY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carboxypeptidase</fullName>
            <ecNumber evidence="12">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G160000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Probable carboxypeptidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="12"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TFY4"/>
    <dbReference type="Gramene" id="KJB42610">
        <property type="protein sequence ID" value="KJB42610"/>
        <property type="gene ID" value="B456_007G160000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803346"/>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GRFLHYW"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000143">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF254">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112868" description="Carboxypeptidase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB42610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="491" mass="54974" checksum="DE62B305A75E8839" modified="2015-04-29" version="1">MADNFLYFCLFCSLVVLTQSAPEEALVTQLPGFSGTFPSKHYSGYVNVDQNHGKNMFYYFVESERNPSEDALVLWLNGGPGCSSFDGFVYEHGPFNFEAAKANESLPQLHLNPYSWSKVSNIIYLDSPVGVGFSYSKNKSDYETGDVQTAIDTHAFLLKWFELYSEFLPNPFFIAGESYAGVYVPTLSSEVVKGIVAQKKPIPNFKGYLVGNGVADDEFDGNALVPFAHGMGLISDELYEEVNSECKGNFYIPLSETCESKLEKVEKNIEDLNIYDILEPCYHAPETLENTDIKIRLPSSFRKLGETNRPLAVRTRMFGRAWPLRAPVRDGIVPTWPQLLDAESVPCTDDTVATQWLNDPAVRKAIHAEEETAIGKWELCTDKILYDHDAGSMIVYHKNLTSGGYRALIYSGDHDMCVPFTGSQAWTRSIGYEIVDEWRPWMSNGQVAGYLQGYANNLTFLTVKGAGHTVPEYKPEEALDFYSRFLAGKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGC6</accession>
    <name>A0A0D2TGC6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Uncharacterized protein ycf72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G032000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ycf72 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGC6"/>
    <dbReference type="Gramene" id="KJB74823">
        <property type="protein sequence ID" value="KJB74823"/>
        <property type="gene ID" value="B456_012G032000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038860">
        <property type="entry name" value="YCF72"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37377">
        <property type="entry name" value="RIBULOSE BISPHOSPHATE CARBOXYLASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37377:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB74823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="8161" checksum="6E1C291526C9C72A" modified="2015-04-29" version="1" fragment="single">PALPKLFWFTPTFPTCLTVAEQFLDIKRTSPERNFNFRTARAALANCPPLPSVISMLCMAVPKGIPIEVYSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKL0</accession>
    <name>A0A0D2TKL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyisobutyryl-CoA hydrolase</fullName>
            <shortName evidence="2">HIB-CoA hydrolase</shortName>
            <shortName evidence="2">HIBYL-CoA-H</shortName>
            <ecNumber evidence="2">3.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">3-hydroxyisobutyryl-coenzyme A hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G062800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-methylpropanoate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20888"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57340"/>
            <dbReference type="EC" id="3.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKL0"/>
    <dbReference type="STRING" id="29730.A0A0D2TKL0"/>
    <dbReference type="Gramene" id="KJB55096">
        <property type="protein sequence ID" value="KJB55096"/>
        <property type="gene ID" value="B456_009G062800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768158"/>
    <dbReference type="eggNOG" id="KOG1684">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000027">
        <property type="entry name" value="Probable 3-hydroxyisobutyryl-CoA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004127">
        <property type="entry name" value="PRK05617.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176:SF14">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl-CoA hydratase/isomerase" evidence="3">
        <location>
            <begin position="51"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB55096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="405" mass="45692" checksum="96AD1082C58E5F8B" modified="2015-04-29" version="1">MQRVKAVLKARHSFQRLGILSHQRCLSAQPNYALYDDFEDQVLVEGRAKSRAAILNRPSALNALTASMAARLKRLYESWEENPDIGFVLMKGNGRAFCSGVDTVALHRLLNEGKVYECKRFFETLYKFVYLQGTYLKPHVAIFDGITMGCGGGISLPGMFRLVTDKTVFSHPETQLGFHPDAGASFYLSRLPGYLGEYLALTGDKLNGVEMIACGLATHYCLNARLAWIEERLGNLMNDDPAVIDSSLAQYGDLVYPDRSSILRRIDTIDKCFSHDTVEEIIDSLENEAAGAYDDWCKTVLRKMKEASPLSLKVTLRSIREGRFQSLDQCLAREYRISLAWISKSVSNDFTEGVRARLVDKDFAPKWYPASLEEVSKDMVEYYFTPLGELEPELVLPTSLREPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TL74</accession>
    <name>A0A0D2TL74_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G251800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TL74"/>
    <dbReference type="STRING" id="29730.A0A0D2TL74"/>
    <dbReference type="Gramene" id="KJB44420">
        <property type="protein sequence ID" value="KJB44420"/>
        <property type="gene ID" value="B456_007G251800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804376"/>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EIYPWTI"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
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    <accession>A0A0D2TMW6</accession>
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        <name type="scientific">Gossypium raimondii</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <text evidence="8">Belongs to the WUS homeobox family.</text>
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    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPU5"/>
    <dbReference type="Gramene" id="KJB77558">
        <property type="protein sequence ID" value="KJB77558"/>
        <property type="gene ID" value="B456_012G143600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="92" mass="9051" checksum="271C4D4880A526AF" modified="2015-04-29" version="1" fragment="single">GTLGNSGLGNSGTLGNSGFGNSGILGSSGFGISGNSGFGSSTFGNDGMSGNSGLGISGTDVSKRRRAPTKTVLLLIDDKVINKKGNTKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSE5</accession>
    <name>A0A0D2TSE5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Disease resistance protein RGA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G364400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TSE5"/>
    <dbReference type="Gramene" id="KJB46385">
        <property type="protein sequence ID" value="KJB46385"/>
        <property type="gene ID" value="B456_007G364400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GMESSIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000322">
        <property type="entry name" value="Probable disease resistance protein At1g63360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057135">
        <property type="entry name" value="At4g27190-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056789">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF40">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25019">
        <property type="entry name" value="LRR_R13L1-DRL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23247">
        <property type="entry name" value="LRR_RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0611">Plant defense</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="6">
        <location>
            <begin position="186"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="9">
        <location>
            <begin position="429"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="R13L1/DRL21-like LRR repeat region" evidence="10">
        <location>
            <begin position="663"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein At4g27190-like leucine-rich repeats" evidence="8">
        <location>
            <begin position="893"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB46385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="127956" checksum="AC2DF02A7A0DBD3B" modified="2015-04-29" version="1">MAEAIAFDLALELITKLSSFTLSQIGLCWNVKDDLDDLKSTVSTIKAVLLDAEERSATSQLVKDWLEKLKDVLYDADDLLDDFFTEALRKDLLGGNKLTKEVRFFFSSSNQFAYGLKMGRKIKTIKARLISIGSEAKVFNLVERDRPMETSFMTKKRQLTHSFKDKIIGRDDDKTALLKLVLEFESEENVYIIPIVGFGGLGKTALAQFVYNDEMVKNHFELMMWVCVSDVFDVKIIVENIIKSATGKAPDQNLEMDQLQKQLREKIGGKKYLLVLDDIWNDEWEKWVSLKELLVGGAKGSRIIVTTRSSKVAKITSKCQPYVLNGLSDNDAWSLFKEIAFEQRSADSTDSGFVEIGKLILERCCGVPLVIRTIAGTLSFKETKSEWLSFKDNELAGISQNDGEILPTLKLSYDHLPSHLKHCFAYCRLYPKDYRIRVQALVQFWIAQGFIKQLNQSQSLEEIGFGYFKDLVERSFFQEVEGDLMEEMRCKMHDLMHDLAESVAGMESSIIDSNNIASDVGEKCRHISINPLLIPSLIPLFKGKKLRTLLRHPNNFSRNLSEETWDFVIANCRCLRVLDLHLLGIQMIPPSIYKLKHLRYLDLSYNRGLKILPKSICKIQNLLALKLNLCTGLKELPKKIEKLVNLTHLGCEGCFSLTHMPHLSELRLLNNLRGRLTIRNLGSVKNAKEKFKAANLKEKQHLSSLHLEWNVDNDDEDDNVKSLEDLQPHPNLKELYIAGWRGDAKFPSWLSLLTNLVDMRIYGGKFKHLPSFAQFPCLQDLVICDLTELEYMDDNSPKGSQGEPQSFFPSLKHLSLLDCPNMKNWWRTTKPIDDDSNEEDTTVIGTSTMAFPCLSSLKIKNCPLTLMPLYPSVDEDLMLSNTSSRALKQTMKMNITSTTPSTSTSSLPLSKLKSFDVRNIEWLDTHTLDECLQHLASLKRLTIRDCKEVDLEGMQWEPLKNLSHLEIDNIPKLVSLPIWLQHLVQLKTLKIHNCNGLRSLLPVFQHLTFLEEFEVKDCKELELSAAGIQIFQDHTSLRSLRLQNIPKCRHLPEGLQHLTNLQGLYLVNLPNLTSLPDEMRCLTSLKSLQIQEIPQLEETCRKDIGADWQKIAHIPNIRLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTD3</accession>
    <name>A0A0D2TTD3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_013G022800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTD3"/>
    <dbReference type="STRING" id="29730.A0A0D2TTD3"/>
    <dbReference type="Gramene" id="KJB78848">
        <property type="protein sequence ID" value="KJB78848"/>
        <property type="gene ID" value="B456_013G022800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHYIHRI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829:SF2">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01434">
        <property type="entry name" value="NADHDHGNASE5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01435">
        <property type="entry name" value="NPOXDRDTASE5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NADH-Ubiquinone oxidoreductase (complex I) chain 5 N-terminal" evidence="11">
        <location>
            <begin position="75"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:quinone oxidoreductase/Mrp antiporter transmembrane" evidence="10">
        <location>
            <begin position="138"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB78848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="22487" checksum="7ABF8143A1B20E71" modified="2015-04-29" version="1">MEHAYQYSWIIPFVPLLIPILIGMGFLLFTTATKNLRRIWTFPNILLLSIVMIFSLDLSIQPINGSSIYQYVWSWTINNDFSFEFDYFIDSLISILITTVGIFVLIYSDNYMSHDEGYLKFFAYMSLFNTSMLGLVISSNLIQIYIFWELVGMCSYLLICFWFTRPAAAKAFQKAFLNYKFLPSPSFHSLYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYM4</accession>
    <name>A0A0D2TYM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G324900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TYM4"/>
    <dbReference type="STRING" id="29730.A0A0D2TYM4"/>
    <dbReference type="Gramene" id="KJB60771">
        <property type="protein sequence ID" value="KJB60771"/>
        <property type="gene ID" value="B456_009G324900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771332"/>
    <dbReference type="eggNOG" id="ENOG502QPUJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.760:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5015213375" description="Expansin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="8">
        <location>
            <begin position="52"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="9">
        <location>
            <begin position="170"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB60771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="253" mass="27199" checksum="610C14EC7544CE08" modified="2015-04-29" version="1">MFACLVCRKMGFAGVLLLGFLAMVSSGHGYDGGWINARATFYGGSDASGTMGGACGYGNLYSQGYGTNTAALSTALFNDGLNCGSCYEIKCMNGDGKWCLRGSIVVTATNFCPPNDAGGWCNPPQHHFDLSQPVFQHIARYKAGIVPIAYRRVPCKRNGGIRFTINGNSYFNLVLITNVGGAGDVHAVAIKGTRTGWQTMSRNWGQNWQSNSYLDGQSLSFKVTTSDGRTVVSYNVAPPNWSFGQTFTGNHFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U4Q1</accession>
    <name>A0A0D2U4Q1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G444900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U4Q1"/>
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        <property type="protein sequence ID" value="KJB62951"/>
        <property type="gene ID" value="B456_009G444900"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="68" mass="7634" checksum="135C256AB366AE88" modified="2015-04-29" version="1">MPAAVVVKKVVPEKMRLHPAVSRVLTLGFVAVTVNWLFLPQLARNGVEENIIEEYSKLMDLFKGNPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U5U8</accession>
    <name>A0A0D2U5U8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G231500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U5U8"/>
    <dbReference type="Gramene" id="KJB83148">
        <property type="protein sequence ID" value="KJB83148"/>
        <property type="gene ID" value="B456_013G231500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FKMGHRM"/>
    <dbReference type="OrthoDB" id="2018467at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051707">
        <property type="term" value="P:response to other organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14798">
        <property type="entry name" value="RX-CC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001091">
        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058922">
        <property type="entry name" value="WHD_DRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF67">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18052">
        <property type="entry name" value="Rx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23559">
        <property type="entry name" value="WHD_DRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="5">
        <location>
            <begin position="169"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance protein winged helix" evidence="7">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="8">
        <location>
            <begin position="550"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB83148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="840" mass="97046" checksum="7589F4EB631ECEDE" modified="2015-04-29" version="1">MAETFLFNIAKRVLAKIGNLSVDEVRLAFNVKTDLKKLEDTMISIKAVLLDAERQQHQNEKLRLCMWKLRDIFYDAEDVIDDFKCEALRKQDAINHRDNNLKVRVLGSCCLPLSFSLKMSHKIKDINGRLGELATEWKSFDLRQCSDNRHVFRRETISFVDSSDVIGRDEDKENIISMLMKPSEARNVPVIPIVGIGGLGKTTLAQLVYNDDRVTSLFPLKIWICVSEEFDLSRLLRLIIQSVNKGERCDDSTLDALQARLRSLLTEKKFLLVLDDVWNENKAKWVELRNLLRSTDGFSPSKIIVTTRSLNVASIMSSIPPYILKGLPLEDCLTLFTKWAFNDGDERHYSNLIRIGEEIVKKCKGVPLAVRTLGSLLFQKTDESDWIYIRESEIWRLEQHENDILPVLKLSYNHLPSHLQRCLAFLSLYKKDEIYYSDRVIYLWMANGLLEHPKQNQEREDVGKRYLNELLSRCLIQMEQDLVHDLALDVSQKECKTMNSETETVDENVRHLLLCDEKLVEVPRVLGEMKNVKTVIIQDASEASKTIHESLINLCVSNFKYLRTLELRDSPLSALPNSIGTLKHLRDLDLAKCEGIRELPRSFYKLRSLQFLNLEGTGLKQLPDSVQRLIELRHLVITIKATHLKEIRAGCWTSLQYLKLHYCTKLECLPEGMQYLKSLRTLVLNDCVKLVSLPRSLKFLSKLEHLEIVGCLLINLKMELEEEEKDLQLSLKTLSLFVLPALRDLPRLLLQGSSSTLQQLRIQFCQNLSVLPAWLPNLTSLQKLEIFNCFNLWDLPEGIDRLTNLRELRIYGCPELSKRYRENGGEDWHKIAHIQKVVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U669</accession>
    <name>A0A0D2U669_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_010G157100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 11">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ELOF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U669"/>
    <dbReference type="SMR" id="A0A0D2U669"/>
    <dbReference type="STRING" id="29730.A0A0D2U669"/>
    <dbReference type="Gramene" id="KJB63421">
        <property type="protein sequence ID" value="KJB63421"/>
        <property type="gene ID" value="B456_010G157100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB63423">
        <property type="protein sequence ID" value="KJB63423"/>
        <property type="gene ID" value="B456_010G157100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773310"/>
    <dbReference type="eggNOG" id="KOG3214">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CLDANKK"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB63421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="107" mass="12281" checksum="11C3D1BA12D07B45" modified="2015-04-29" version="1">MGKRKSRAKPAPKKRMDKLDTVFSCPFCNHGTSVECRLDMKNLIGEASCRICQESFSTVITALTEPIDIYSEWIDECERVNNLEEEDDGDQDEGYVPRKRVSTSEWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U7I6</accession>
    <name>A0A0D2U7I6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G021300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U7I6"/>
    <dbReference type="STRING" id="29730.A0A0D2U7I6"/>
    <dbReference type="Gramene" id="KJB63871">
        <property type="protein sequence ID" value="KJB63871"/>
        <property type="gene ID" value="B456_010G021300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QT1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQLGVHF"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000008">
        <property type="entry name" value="Tryptamine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF12">
        <property type="entry name" value="HXXXD-TYPE ACYL-TRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB63871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="455" mass="51184" checksum="B71247197D870BC3" modified="2015-04-29" version="1">MEQSTVRIISECYVTPPHVSDQSKQPYYLTTWDLVMLSVQYIQKGLLYTKPENSCEENLINNVLDRLKQSLSIALVHFYPLSGRLVTKIEENPKSHFVFVDCNSSPGAKFIHAAVDLSVSDIVSPTYVPLVVQSFFDHDRAINYDGHTRPLLSIQVTELVDGVFIGCSMNHVLGDGATFWHFFNALSEIFQAQGDTKMKISRPPVLEKWFPEGHGPLLNLPFTNQDEFITRFEAPELLERMFHFSAKSIAKLKERANTESNTIEISSFQSLSAFVWRTITKARRFPNETVTGCRLAINNRSRLEPALPLDYFGNSIQSVRAVTTAGELLHHNLGWAAWKLHQAVVNHTDKQVRGFVNGWLDSPFIYKIAQLFDPQSVMFGSSPRFNMYENEFGLGKALMLRSGYAHKFDGKVSSYPGREGGGSVDLEICLPPSSMKALELDEEFMSVVSSGGIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHS8</accession>
    <name>A0A0D2UHS8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_010G197700</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHS8"/>
    <dbReference type="STRING" id="29730.A0A0D2UHS8"/>
    <dbReference type="Gramene" id="KJB67571">
        <property type="protein sequence ID" value="KJB67571"/>
        <property type="gene ID" value="B456_010G197700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774219"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWRTGDT"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000357">
        <property type="entry name" value="serine/threonine-protein kinase-like protein CCR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000569">
        <property type="entry name" value="Serine/threonine-protein kinase-like protein CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46146:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE-LIKE PROTEIN CCR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265599" description="non-specific serine/threonine protein kinase" evidence="19">
        <location>
            <begin position="27"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="394"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="504"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB67571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="813" mass="87777" checksum="DAF319CC9455703F" modified="2015-04-29" version="1">MTKLFFPLLFAVSSLAVISFPPLTHALGSGLTLAVAYGTATVCAIVAAQPTQRIICYRAGDNTSSSIAPVPILPNVSYFTVAGGETNLCALRSGGYSLLCWETNAPNYPVKRLYVNDTVFLQSLSIGDERICATTTNTSQPVACWRPDGNNRNDVGELPNRNYTMGKITSGFGFSCGIVLSQNNRVACWGSNSVVSTDIERQFGNISMENIEAGVSHVCGVNSVGDLVCKGNNSAGQLNVPLNKGLRFASWLALGEGFSCGIRRLNGTVVCWGSMTESAIEDIEFESIVAGLNFTCGLTTKNLSIVCWGPGWPGNNGFNSNYSFELPLMAEILPGPCVQSFCSECGIYPESNRLCSGSGNICRPCFNITTASPPSPVAPSPEVSRPSRELRRGLLAFAIVGSIGGFMGICSAIYCLWTGVCFGKKKVHNSVQPTITRAGSNGGPGSNNSPPSRSLRIRRQSSRAMKRQRSGPSMIRQRSGTSSKHADKAEEFSFAELVAATNGFSLENKIGAGSYGVVYKGKLSDGREVAIKRGETGSKMKKYQEKEIAFESELSFLSRLHHKHLVRLVGYCEEMDERLLVYEYMKNGALYDHLHDKNNIEKSSSLLNSWKMRIKIALDAARGIEYLHNYAVPPIIHRDIKSSNILLDANWTARVSDFGLSMMGPESDRDYKPTKAAGTVGYIDPEYYGLNVLTTKSDVYGLGVVMLELLTGKRAIFKESESGGTPVSLVDYTVPAIMNGEVVKVLDPRVGPPELNEAEAVELMAYTAMHCVNLEGKDRPTIGDIVSNLERALTVCDGSHGSISSGAFSIVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULX8</accession>
    <name>A0A0D2ULX8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_011G001200</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULX8"/>
    <dbReference type="Gramene" id="KJB68971">
        <property type="protein sequence ID" value="KJB68971"/>
        <property type="gene ID" value="B456_011G001200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777119"/>
    <dbReference type="eggNOG" id="ENOG502QTQY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AFWIFSK"/>
    <dbReference type="OrthoDB" id="647974at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001653">
        <property type="term" value="F:peptide receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031347">
        <property type="term" value="P:regulation of defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000309">
        <property type="entry name" value="Leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000125">
        <property type="entry name" value="Protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000213">
        <property type="entry name" value="Tyrosine-sulfated glycopeptide receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF18">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="17 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="13 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="24" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002268676" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="46"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="714"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="801"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB68971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1086" mass="119629" checksum="790AB61706054A27" modified="2015-04-29" version="1">MMIDDKETSRGASASRPTAFSMLHLLLNLLLLLLQSFFFVSPSQAACDQNDRVFLLAFQSNITAPSSSPLNWSTTTDCCFWEGVACDGPDSGRVSQLWLPSRGLTGHLSTSLLNLTLLTRLNFSHNRFTGFLPSGFFSSLNHLQVLDLSYNSLYGELPLDFISDDNSSLSPIQTLDLSSNHFSGTIRSNSVLQAALNLTIFNVSNNTLTGQVPSWICINTSLTILDLSYNKLDGKIPTGLDKCSKLQIFRAGFNNLSGTLPADIYSVSSLEQLSLPLNHFSGGIRDAIVQLDKLTILELFSNEFEGPIPKDIGQLSKLEQLLLHINNFTGYLPPSLMSCTNLVTLNLRVNHLEGDLSAFNFSTLQRLNTLDLGNNNFTGTLPLSLYSCKSLTAVRLASNQLEGQISPAILALRSLSFLSISTNKLTNITGAIRILKEVKNLTTLILTKNFMNEAIPNDENIIGEGFQNLQILALGGCNFTGQVPKWLAKLKNLEVLDLSQNRISGLIPSWLGSLPNLFYIDLSANLISGEFPKELTSLWALATQESNNQVDRSYLELPVFVMPNNATSQQLYNQLSSLPPAIYLRNNNLSGNIPEAIGQLRFLHVLDLSQNDFSGSIPEQLSNLTNLEKLDLSGNRLSGQIPESLRGLYFLSSFSVAYNNLQGPIPSGGQFDTFTSSSFEGNPGLCGSIVQRICPNAPGAAHSPTLPKRLNTKLIIGLVLGICSGTGLVITVLALWILSKRRIIPGGDTDKIELDTLSCNSYSGVHPQTDKDASLVMLFPNKTNEVKDLTIFELLKATDNFNQENIIGCGGFGLVYKAILADGTKLAVKKLSGDFGLMEREFKAEVEALSTAQHENLVSLQGYCVHEGFRLLIYSYMENGSLDYWLHEKENGPSQLDWQTRLKIARGASNGLAYMHQICEPHIVHRDIKSSNILLDDKFEAHVADFGLSRLILPYHTHVTTELVGTLGYIPPEYGQAWVATLRGDVYSFGVVMLELLTGKRPVDMSRPKTSRELVSWVQRLRSEGKQDEVFDPLLKGKGSDEEMLQVLDVACLCINQNPFKRPTIQEVVEWLKGVGTINRNQNKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2URY5</accession>
    <name>A0A0D2URY5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1-aminocyclopropane-1-carboxylate synthase</fullName>
            <ecNumber evidence="9">4.4.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G222700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:58360"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.4.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.14" evidence="9"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2URY5"/>
    <dbReference type="STRING" id="29730.A0A0D2URY5"/>
    <dbReference type="Gramene" id="KJB58715">
        <property type="protein sequence ID" value="KJB58715"/>
        <property type="gene ID" value="B456_009G222700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767610"/>
    <dbReference type="eggNOG" id="KOG0256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPQGRCY"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016847">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009835">
        <property type="term" value="P:fruit ripening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000038">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000051">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate synthase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF44">
        <property type="entry name" value="1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0266">Ethylene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0292">Fruit ripening</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="39"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00059261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB58715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="468" mass="52994" checksum="54520B134E2CD64B" modified="2015-04-29" version="1">MLSSKASCNSHGQDSSYFLGWQLYENNPFHEVENPTGIIQMGLAENQLSFDLVESWLRKNPEVMELKKGGESVFRELALFQDYHGLPTFKNELVEYMAKMRGNKVKFDPNNLVLAAGATSANETLIFCLADPGEAILLPTPYYPGFDRDLKWRTGVEIVPVHCWSSNGFRITMFALEEAYERAQKLNLKVKGVLITNPSNPLGTTMTKEELDHLITFAMAKNIHVISDEVFSGTVFDSPGFISILEAAMDRNLENTDVWSRIHIVYSLSKDLGLPGFRVGMIYSNNKTVVGASTKMSSFGLVSSQTQYLLTNVLASKRFTSKYMKENQKRLKKRKEMLVSGLKKSGIECLKSNAGLFCWVDMRHLLSSNTLEAETKLWNQMVCDVGLNISPGSSFHCSEPGWFRVCFANMSRGTLQVAMRRIKDFVERSNFMGRIKMNYQQNMSSLSRKLLSNWVRKLSSPDPNEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UX88</accession>
    <name>A0A0D2UX88_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vinorine synthase-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G235600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UX88"/>
    <dbReference type="Gramene" id="KJB73491">
        <property type="protein sequence ID" value="KJB73491"/>
        <property type="gene ID" value="B456_011G235600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SI0I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIFIDHF"/>
    <dbReference type="OrthoDB" id="937078at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF20">
        <property type="entry name" value="VINORINE SYNTHASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51044" checksum="E904F45A01184344" modified="2015-04-29" version="1">MFNFEAKVFAKEIIKPSSPEIHGMKPFKLNIFDQLTPTTYASFMAFYPLIEANFTTTNILPHLKTSLSETLNILYPISGRIKDNIFIDHFHEGVPFLSAQAGCRLSEFLKHHEVKLLNKLLPCQPFSKEFNNEAPLLVCQITMFTCGGIALGVVFSHKIFDAAIIFHLLDVWSKITRGSHHHNVGFHGLANASMLFPPRNEVSQHYLSKVENLWFTEPYNSITMRFTFDAKSIAELRAIAKGELEAMPSRIQAVLGFIWKCSMAASRMISGSFKPFVLAQAVSLRPRMNSNILQNSIGNLFCWTHCVTNLTDQIDTELFELVKLMRKSILTIDDEYLNALQGEKGFKIIGEYINKLETMFSIEKPDFFSSTSWVNIKYYELDFGWGNPQWVAPFGEAGSEFNNNVVFIETKCGKGIEAWITLDEKRMLVLEKDAEFLKFATPNPEISSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UZS2</accession>
    <name>A0A0D2UZS2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G393400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1 9">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the histone H4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UZS2"/>
    <dbReference type="STRING" id="29730.A0A0D2UZS2"/>
    <dbReference type="Gramene" id="KJB61885">
        <property type="protein sequence ID" value="KJB61885"/>
        <property type="gene ID" value="B456_009G393400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WISNMSG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000002">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="10">
        <location>
            <begin position="88"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB61885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="147" mass="16601" checksum="5FA3C8DE9FADF2E9" modified="2015-04-29" version="1">MDHYLNKKLPSSRYKIPRNFVSLLKFPILLSKSLKSLKFGWISNMSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKIFLENVIRDAVTYTEHARRKTVTAMDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V121</accession>
    <name>A0A0D2V121_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B456_012G033000</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="18"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V121"/>
    <dbReference type="Gramene" id="KJB75231">
        <property type="protein sequence ID" value="KJB75231"/>
        <property type="gene ID" value="B456_012G033000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780325"/>
    <dbReference type="eggNOG" id="ENOG502QT6D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TAPYAYW"/>
    <dbReference type="OrthoDB" id="758220at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048544">
        <property type="term" value="P:recognition of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000237">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000059">
        <property type="entry name" value="S-receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.10:FF:000026">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.10">
        <property type="entry name" value="Bulb-type lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000858">
        <property type="entry name" value="S_locus_glycoprot_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF7">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00954">
        <property type="entry name" value="S_locus_glycop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0430">Lectin</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 18" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 21" id="KW-0732">Signal</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253212" description="Receptor-like serine/threonine-protein kinase" evidence="21">
        <location>
            <begin position="22"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="23">
        <location>
            <begin position="25"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="24">
        <location>
            <begin position="334"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="500"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJB75231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="788" mass="87887" checksum="38419CD71840FB2B" modified="2015-04-29" version="1">MVAISFLFLVCSFSFHLHAVAQPRNSTILLGSSLTPTTTGKSAWLSPSGLYGFGFYPQGKGYGVGVFLAGVPQRTVVWTANRDDPPVPSTASLVLTTDGRLILQSPPRRDVYIITDASQKIAAASMLDTGNFVVFNSDGDMIWQSFQYPTTSILQGQRLSAGMELFSSVSETDQSTGIFRLKMQHDGNLVQYPVDTPDTARYAYWSSGTFGIGENVSLNLDNDGHLYMLNSTGFNIKDLTTGGYDDTNRTIYLMKIDSDGIFRLYSYRLDRNGNRSVIWSSTSNKCAPKGLCGLNGYCVDVDREANCICLPGFAPVIERNFTAGCERNFSSDSCKNGDGKIQYTIQAAENTVWEDTGYSEVTSTTREECETACYEDCNCEAAMFNDGKCTKQRLPLRYGRRDLSNSNIALIKVGISSSINEPRKHADEPKDGKGKVHTDILIIGLSLIGFAIMVLVISGALILWSRVFRYKRFSTDSNIRLCENVAPISFSFAEIEAMTDNFQEEIGKGAFGTVFKGTVMLNGLTKFVAVKRLDNISDQGEREFQNEMRIIGRTHHRNLVRLLGYCHDGANRLLIYQYMINGSLSDVLFTPERRPCWIDRVEIARDVARGLLYLHEECETQIIHCDIKSQNILMDENGQAKISDFGLAKLLKPDQTKTFTGIRGTRGYVAPEWHRKLPVTVKADVYSFGIVLLEIICCRRSVNWSLKDEEAILEEWVYDCYQAGKVGKIAGEDEEVDIKQLERMVIVGLWCILDEPTLRPSMKKVLLMLEGTVEIPVPPCPTSFFSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V285</accession>
    <name>A0A0D2V285_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin efflux carrier component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_012G056200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the auxin efflux carrier.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the auxin efflux carrier (TC 2.A.69.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V285"/>
    <dbReference type="STRING" id="29730.A0A0D2V285"/>
    <dbReference type="Gramene" id="KJB75766">
        <property type="protein sequence ID" value="KJB75766"/>
        <property type="gene ID" value="B456_012G056200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780955"/>
    <dbReference type="eggNOG" id="ENOG502QS5F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMYACLI"/>
    <dbReference type="OrthoDB" id="2133778at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010329">
        <property type="term" value="F:auxin efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009926">
        <property type="term" value="P:auxin polar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014024">
        <property type="entry name" value="Auxin_eff_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051107">
        <property type="entry name" value="Auxin_Efflux_Carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00946">
        <property type="entry name" value="2a69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31752:SF40">
        <property type="entry name" value="AUXIN EFFLUX CARRIER COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="267"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="358" mass="38724" checksum="808F7B6A19D69158" modified="2015-04-29" version="1">MISLADVYHVIAATVPLYFAMILAYVSVKWWKLFTPEQCAGINKFVAKFSIPLLSFQVISENNPYKMNLKLILADFLQKLLAFLVLFALTKLSSRGGLSSIITGLSLSTMPNTLILGIPLLRAMYGDKSATLLAQIVVLQSLIWYNLLLFLFELNATKAASETTVAVSQASGGEEAPEEAQGKEGGEETQTRARKSKTMLIFLTVGKKLMANPNTHATLLGLIWASIQFRWNIKFPAIVEKSIAILSSGGLGMAMFSLGLFMASRPSIIACGIRMATVAMIMKFIAGPALMAAASTTLGLKGKLLRVAIVQAALPQGIVPFVFAKEYNVHPDILSTGVIFGMLIALPVALVYYLLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V293</accession>
    <name>A0A0D2V293_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_009G447900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V293"/>
    <dbReference type="STRING" id="29730.A0A0D2V293"/>
    <dbReference type="Gramene" id="KJB62995">
        <property type="protein sequence ID" value="KJB62995"/>
        <property type="gene ID" value="B456_009G447900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKECKND"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000383">
        <property type="entry name" value="Leucine-rich repeat receptor protein kinase EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48061:SF46">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING N-TERMINAL PLANT-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="13">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB62995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="982" mass="108904" checksum="4B6A9BAB423E7521" modified="2015-04-29" version="1" fragment="single">SHSCSSLIQFKDSFSITEDVSSYCNDYAGLKSYPKTNSWKEGTDCCSWDGVTCDHLNAHVIALDLSCSWLYGNFPSNTTLFLLPHLQKLNLAYNDFNLSKIPSEFGRFTSLFYLNLSYTGFAGEVPSQVSHLSKLVSLDLSFWANVLTIDKHALEGLVHNLTEVRHLFLDGINMTSVNAHVFMNLSSSLRSLSLAGCDLQGKFPKNIFDLPNLNLLNLGGNQNLNLDPLKLNRSSNLEHLDLSWMSFSTEFIDSVDNLQALKYFDLSGNSFFQGLSVSITNLSSLEYLILRGANFFGGLPDSMGNLVSLKFLDLSYSNLSGPVPKSLGNLLQLTHLDLGSNKLNEVTAVPNLIYLVLFDNVLNGTLPSWLYTAPSLKGIILSQNQFSGHIKEFQTKSLEYLDLENNKLQGPLPSSIFQLLNLTWLLLSSNNLSGVIEFRMFSNVPNLKHLDLSYNSLSLTSNATSSVNHILPNVTDLLLSSCNLSEFPQFLKGLKSLESLDLSCNKIEGKIPQWMQEVGNGSLTYLNVSHNSLTEVEHFPWKNIEVLDLSSNLISGNLPIPASTINFFLISNNSLNGEVSSLICNATSLRVLDLSHNNLSGTIPRCFGNLSNSLEFLNLKKNKFYGTIPPNFAQGCRLTNFNLNGNLLEGPLTPSILNCRGLEVLDLGNNKINDTFPHWLGSLPYLQVLVLKSNHMHGSLRVNSSKSSPFFSKIQIFDLSSNYFSGPLPVRYINSFKAIIDLEKIGSTMSYMGVYVQRGSGFYTYSIGIVMKGQYMELVKIFTMWMIIDLSNNQFEGGIPKVFGKLNLLKGLNLSHNNLSGGIPTSIGNLTSLEWLDLSSNRLSGTIPNRLADLPFLSSFNVSENQLHGQIPQGKQFNTFGNDSYEGNKGLCGFPVSKGCNIIEPAPPNVLEKDGSKSNIAFGWKVVLIGYGCGVVFGMSVGYVVFETGKPKWLVNLVENQQEKRRRRKSKKGNRSDRRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V2B5</accession>
    <name>A0A0D2V2B5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G060200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V2B5"/>
    <dbReference type="Gramene" id="KJB75831">
        <property type="protein sequence ID" value="KJB75831"/>
        <property type="gene ID" value="B456_012G060200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780009"/>
    <dbReference type="OMA" id="IQTRIME"/>
    <dbReference type="OrthoDB" id="1727045at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="28"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="8">
        <location>
            <begin position="185"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB75831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="353" mass="38181" checksum="595F98EA8EAD43EF" modified="2015-04-29" version="1">MAGKWGYRDVVPITAMVAVECSDVVLSILFKAASLKGMSYFVYIAYCYVLATLVFVPLAFLSNRKKLLIPLEFPLISRICLLGLLGFSGQVCAYKGLELGSPTLASAISNLAPAFTFILAVLFRIEKVSFTSSTAQAKIIGTLTSISGALLIVLYKGPKVIPSSTSSSVSLQWPLESTQSNWVIGGLLEALAYLFFSFWYIVQSKVMKIYPEEITVNVYYNMSVAIIALAACLIKEQNLSSWTLHPSISVVSVLYSGLFGFPFSSGVHTWGVRVKGPVFVAIFRPTSIVIAVIMSAIFLGEAVYLGSVIGGVILTIGLYAVLWGKAKEEEMKDDGSGLSTKAPLLKSQNVEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5B1</accession>
    <name>A0A0D2V5B1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G039300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5B1"/>
    <dbReference type="Gramene" id="KJB64245">
        <property type="protein sequence ID" value="KJB64245"/>
        <property type="gene ID" value="B456_010G039300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1947">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SDPHCWQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000022">
        <property type="entry name" value="F-box protein FBW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF80">
        <property type="entry name" value="F-BOX DOMAIN, LEUCINE-RICH REPEAT DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB64245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="248" mass="28206" checksum="DA45A9A608EBFFF2" modified="2015-04-29" version="1" fragment="single">MEEEQSEFRHWDELLPDVLGLIFTNLSLQELLTIIPCVCKSWRKTVGDPHCWQDIDLDEWSCRWQPYQLDRMLRMLVRRSSGSLRRLHVSGLKNDSIFSFVTENAGSLQVLRLPHSKISDSIVEQTAPRLSTVTFLDLSYCPKIGAQAIEAIGKHCKLLVTLCRNMYSSDSAGKVEPEDEANAIAATMPRLKHLELGFHLISTECVLNILSSCPQLKHLVIDGCPQVKLDRKFLKEKYPKLKVVGPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V5M4</accession>
    <name>A0A0D2V5M4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G150600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V5M4"/>
    <dbReference type="Gramene" id="KJB77686">
        <property type="protein sequence ID" value="KJB77686"/>
        <property type="gene ID" value="B456_012G150600"/>
    </dbReference>
    <dbReference type="OMA" id="TMLVKRM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37705">
        <property type="entry name" value="BNAA08G11710D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37705:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB77686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="9451" checksum="6381C7FE5CB31015" modified="2015-04-29" version="1">MKLRKRRRKKKKAAAERAKSFATMLVKRMEICIELVKFAIKFVIAQVEEVINENLRHRRPPPPVAMRMRSLSPPLPFVGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA14</accession>
    <name>A0A0D2VA14_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acyl-aliphatic-L-amino acid amidohydrolase</fullName>
            <ecNumber evidence="3">3.5.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N-acyl-L-amino-acid amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G064900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.14" evidence="3"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VA14"/>
    <dbReference type="STRING" id="29730.A0A0D2VA14"/>
    <dbReference type="Gramene" id="KJB79746">
        <property type="protein sequence ID" value="KJB79746"/>
        <property type="gene ID" value="B456_013G064900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782851"/>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTCPEQW"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004046">
        <property type="term" value="F:aminoacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05646">
        <property type="entry name" value="M20_AcylaseI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000019">
        <property type="entry name" value="Aminoacylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000009">
        <property type="entry name" value="aminoacylase-1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000001">
        <property type="entry name" value="Aminoacylase-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052083">
        <property type="entry name" value="Aminoacylase-1_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010159">
        <property type="entry name" value="N-acyl_aa_amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01880">
        <property type="entry name" value="Ac-peptdase-euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45892:SF1">
        <property type="entry name" value="AMINOACYLASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036696">
        <property type="entry name" value="ACY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254086" description="N-acyl-aliphatic-L-amino acid amidohydrolase" evidence="11">
        <location>
            <begin position="29"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="12">
        <location>
            <begin position="216"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036696-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB79746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="454" mass="51024" checksum="971A56A99ECAC36E" modified="2015-04-29" version="1">MEKLCNFNHEFIIVHLLLFASLLSFTNPTPSPTQDEQSQIISRFQEYLRINTSQPSPDYKKSTQFILTLAESLSLETQVIEFVQGKPLVILKWPGSDLSLPSILLNSHTDVVPSESSKWDYHPFGAHIDENGNIFARGSQDMKCVGMQYMEAVRRLKASGFQPKRSLYLSFVPDEEIGGHDGLEKLAQSDVFKNMNVDIILDEGLASPNENYRLFYGERTPWWLVIKATGAPGHGAKLYDNSAMENLFKSIESIRRFRASQFDLVKAGLKGEGEVISVNMAFLKAGTPSPTGFVMNLQPSEAEAGFDIRIPPTVNAESLEKRIAEEWAPASRNMSFEFKQKGSTQDFWGRPLITATDRSNPWWALLVEAVKKANGKIGKPEIFPAATDSRYFRQQGLRAIGFSPMANTPVLLHDHNEFLNQAEYLKGIDVYESIIKAYTSYIPPGRDSLSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VB41</accession>
    <name>A0A0D2VB41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_013G054900</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VB41"/>
    <dbReference type="STRING" id="29730.A0A0D2VB41"/>
    <dbReference type="Gramene" id="KJB79569">
        <property type="protein sequence ID" value="KJB79569"/>
        <property type="gene ID" value="B456_013G054900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783354"/>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KICHNCG"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000013">
        <property type="entry name" value="Dynamin-related protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000018">
        <property type="entry name" value="Dynamin-related protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001027">
        <property type="entry name" value="dynamin-related protein 3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="3" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="15">
        <location>
            <begin position="46"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="14">
        <location>
            <begin position="658"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="778"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="607"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="800"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB79569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="831" mass="91632" checksum="CF9A40197623FF87" modified="2015-04-29" version="1">MAEEAAAVAASAQPPPQSSVAPLGSSVIPIVNKLQDIFAQLGSQSTIELPQVAVVGSQSSGKSSVLESLVGRDFLPRGNDICTRRPLVLQLLQTKRKLDGSEEEYGEFLHLPGKRFYDFSEIRREIQAETDREAGGNKGVSDRQIRLKIFSPNVLDITLVDLPGITKVPVGDQPSDIEARIRTMIMSYIKQPSCLILAVTPANSDLANSDALQLAGNADPDGTRTIGVITKLDIMDRGTDARNLLLGKVIPLRLGYIGVVNRSQEDILLNRSIKDALVAEEKFFRSRPVYNGLADRCGVPQLAKKLNQILVQHIKAILPGLKSRISSALVSLAKEHASYGEITESRAGQGALLLNILSKYCEAFSSIVEGKNEEMSTSELSGGARIHYIFQSIFVKSLEEVDPCEDLTDDDIRTAIQNATGPRSALFVPEVPFEVLVRRQIARLLDPSLQCARFIYDELIKISHRCMVNELQRFPVLRKHMDQVIGNFLREGLEPSETMIGHIIEMEMDYINTSHPNFIGGSKAVELANQQFRNSRVALPISRSKDGLETDKAPGSERSVKSRAIIARQVNGIVADQGARPVADVEKAPSSGTSGSTWVSSIFGGSDNRSSAKESSTNKPYTEPVHNMEQAFSMIHLREPPSVLRPSEDRSETEAIEIAVTKLLLRSYYDIVRKNIEDSVPKAIMHFLVNHTKRELHNVFIKKLYRENLFEEMLQEPDEIASKRKRTRETLRVLQQAFRTLDELPLEAETVERGYSLGSDPTGLPKIHGLPTSSIYSSGGSDDAYTASPKNPKSRKSSHSGELSTHSYANNTDSNGSGRSYMPGLYPTVDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VC53</accession>
    <name>A0A0D2VC53_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin receptor RAD23</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">DNA repair protein RAD23</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_013G076800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAD23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VC53"/>
    <dbReference type="STRING" id="29730.A0A0D2VC53"/>
    <dbReference type="Gramene" id="KJB79998">
        <property type="protein sequence ID" value="KJB79998"/>
        <property type="gene ID" value="B456_013G076800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB79999">
        <property type="protein sequence ID" value="KJB79999"/>
        <property type="gene ID" value="B456_013G076800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0011">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VACCVRI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14379">
        <property type="entry name" value="UBA1_Rad23_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14382">
        <property type="entry name" value="UBA2_RAD23_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01805">
        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000069">
        <property type="entry name" value="UV excision repair protein RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.540:FF:000001">
        <property type="entry name" value="UV excision repair protein RAD23 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF35">
        <property type="entry name" value="UBIQUITIN RECEPTOR RAD23C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="151"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="8">
        <location>
            <begin position="337"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB79999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="384" mass="40687" checksum="3C3D3AE52791C7D7" modified="2015-04-29" version="1">MKVSVKTLKGTHFDIEVKPEDAVADVKKNIETVQGTDVYPASQQMLIYKGKVLKDDTTLAENSVTENSFIVIMLTKNKGTTGEGSAASTAPTKKDPEASNLPTAPAPASTAPVATSAMAAAAAESAPVASSTPLSDSDVYGQAASNLVAGSNLEGTIQQILDMGGGTWDRDTVVRALRAAYNNPERAVEYLYSGIPEQAEAPPVARAPVVGQTTNPAAQPQQPAQTAAVPTSGPNANPLDLFPQGLPNMGASGAGAGTLDFLRNSPQFQALRAMVQANPQILQPMLQELGKQNPNLMRLIQEHQGDFLRLINEPAEGGEGNILGQLAEAMPQAVQVTPEEREAIERLEAMGFDRATVLQVFFACNKNEELAANYLLDHMHDFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VH94</accession>
    <name>A0A0D2VH94_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Benzyl alcohol O-benzoyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_013G185700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VH94"/>
    <dbReference type="Gramene" id="KJB82264">
        <property type="protein sequence ID" value="KJB82264"/>
        <property type="gene ID" value="B456_013G185700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUSI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RITFTHR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050898">
        <property type="entry name" value="Plant_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147:SF66">
        <property type="entry name" value="OS05G0315700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB82264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51491" checksum="571DC7A280F62404" modified="2015-04-29" version="1">MHPFVMATPSNIPLEFTVRRCEPELVTPAKPTPYEQKLVSDIDDQEAFRLHVPIFNFYQYEPSMEGKDPAEIIREALAQTLVCYYPFAGRLREGANGKLIVDCTGEGVMFIKADADVTLEQFGEPLLPPFPYLDQLLYDVPGSEGILNCPLLLVQVTRLKCGGFIFTLRLNHVMSDATGLAQFLFALGEMARGVATHLISPVWERHLLDARHPARITFTHREYDEVEAPVTTPITILPFDNPVQRSFSFGFAEVSLLRSLLPPHLHRCTTFELITACLWRCRTLAINLDPDEEVRMLCVVNACSKFNPSFPSGYYGNVIVLPAAVTTVKSLCEKPLGYAVELIKQAKASVTEEYVKSVAALTVARGKRIHFPNVIGTYIISDLTKAGFEDIDFGWGKAVFGGPMIAVGVISHLMPTKNKKGEVGIVTSVCLPAPVMERFAKELDMLKHQASEGKKSKSNSISSAL</sequence>
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        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266049" evidence="1">
        <location>
            <begin position="19"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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        <lineage>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0603182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W7M1"/>
    <dbReference type="STRING" id="29730.A0A0D2W7M1"/>
    <dbReference type="Gramene" id="KJB82430">
        <property type="protein sequence ID" value="KJB82430"/>
        <property type="gene ID" value="B456_013G195100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781209"/>
    <dbReference type="eggNOG" id="KOG4177">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SDWFTAK"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118">
        <property type="entry name" value="POTE ANKYRIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24118:SF99">
        <property type="entry name" value="POTE ANKYRIN DOMAIN FAMILY MEMBER 3C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MSP" evidence="2">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="238"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="364"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="392"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB82430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0603182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="540" mass="58727" checksum="877983ED522155D2" modified="2015-04-29" version="1">MDRLISLEPSNLVAVRIELGQKCFGELTLRNVMFTMPVAFRLQPVKKGRYSVKPQSGIIVPLGTLTVEIVYLLPPGSFLPDSFPFTDDSFLLHSVVVPGAAMKDSTSSYDAVPNEWFTTRKKQVFIDSGVKIMFVGSPVLVQLVMDGSMDEIREVLERSDPSWRPADSVDSHGQSLLHVAIAHSRPDIVQLLLEFEPDIEFQSRYGSTPLEAASGCGEELIVELLLAHKASPDRSESSSRGPIHLAIIGGYFEVLRLLLLKGANVDALTKDGNTALHLAVENRRRDCTRLLLANGADPSVRNTRDGDTALHVAAGLGDEQMVKLLLQKGVNKDIRNKTGKTAYDVAAEHGHMRLFDALKLGDNLCLAARKGEVRAIQRLIENGAAINGRDQHGWTALHRASFKGGTDAIKILIDKGIDIDSRDEDGYTALHCAVESGHAEVVELLVKKGADVESRTNKGVKPLQIADSLHYVGISRILIHGGATTTGGMPRVSAMPDSVPFGNGKIGKEIETKKAPMRRRPAKARAVRGSFDRSLPLAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LVF4</accession>
    <name>A0A0D2LVF4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_001G061900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 2-oxoglutarate + O2 = N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:60228"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15539"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:60229"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2-oxoglutarate + O2 = N(6)-methyl-L-lysyl(27)-[histone H3] + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:60232"/>
            <dbReference type="Rhea" id="RHEA-COMP:15539"/>
            <dbReference type="Rhea" id="RHEA-COMP:15544"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:60233"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the JHDM3 histone demethylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2LVF4"/>
    <dbReference type="Gramene" id="KJB08072">
        <property type="protein sequence ID" value="KJB08072"/>
        <property type="gene ID" value="B456_001G061900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786591"/>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AENDATC"/>
    <dbReference type="OrthoDB" id="9547406at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071558">
        <property type="term" value="F:histone H3K27me2/H3K27me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000028">
        <property type="term" value="P:regulation of photoperiodism, flowering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048580">
        <property type="term" value="P:regulation of post-embryonic development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009741">
        <property type="term" value="P:response to brassinosteroid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009826">
        <property type="term" value="P:unidimensional cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000023">
        <property type="entry name" value="Probable lysine-specific demethylase ELF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000747">
        <property type="entry name" value="Probable lysine-specific demethylase ELF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF38">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE REF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="JmjN" evidence="19">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="20">
        <location>
            <begin position="200"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1496"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1526"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="18">
        <location>
            <begin position="1556"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="670"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1224"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1259"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1297"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1324"/>
            <end position="1334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1380"/>
            <end position="1396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1432"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1452"/>
            <end position="1463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00050682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1588" mass="180137" checksum="1183BABA77BE4F38" modified="2015-04-29" version="1">MACSSHHSLEQSQEAFSWLKSMPLAPEYRPTLAEFQDPIAYIFKIEKEASQYGICKIIPPVPPASKKTAIGNLNRSLLVRAEANASSDLKPTPTFTTRQQQIGFCPRKPRPVQKPVWQSGEYYTFQEFEAKAKSFERNYLKKYSKKGTLSALEVETLFWKATVDKPAMVEYANDMPGSAFVPLNPKKSSGGGREAGEGVTVGETPWNMRAVSRAKGSLLRFMKEEIPGVTSPMVYIAMLFSWFAWHVEDHDLHSLNYLHMGAGKTWYGVPRDAAVAFEEVVRLDGYGGEFNPLVTFSTLGEKTTVMSPEVFLHAGIPCCRLVQNAGEFVVTFPRAYHSGFSHGFNFGEAANIATPEWLRVARDAAIRRASINYPPMVSHFQLLYDLALELCSRIPMSISAKPKSSRLKDKRKSEGENLVKELFVQNLIQNNNLLHILGKGSSVVLLPKSSSDISLCSHLRCQSRINPRMSLSLYKDIIKSSKDVGSDETVIGGNEEIKGIKGFYSVKGNFASMYEGNRDSSFRGNDYSCRFPSQTSNTTRERDSAILDDALPDQRLFSCVTCGILCFACVAVLQPTDQAARYLMSADCSFFNDWTVGSGVTHDGFNAAHGDAITSEQNPCSRRMNKSAPNSLYDVSVQPVDSKFRMGDQSNQVLEDTEKRGESSALGLLASTYGNSSDSEEDLPEPNATIFHDETNPTNVSPERKIQYNDSGFSPSDVNTSRNPSLSRLDSEEESPFDIKNGSPETFDPDLEFKTDNLISRRSNGLEDKFRDPMTSSHVNPNYSRAAHGIEKMRFSMAVLPMENVDIPFVQRTDEDSSRMHVFCLEHAVEVEQQLRQIGGVQVFLLCHPEYPKIEAEAKLVAEELGIDYPWNDILFGDATKDDKERIQSALDSEDAIPGNGDWAVKLGINLFYSANLSRSTLYSKQMPYNWIIYSAFGRNSSDSSLKKLNVYGRRSGKPRKVVVGKWCGRVWMSNQVHPFLAQRDSEEQEQERSFHAQAISDENVERKPENVPKAETMKVVNRKRKSRAEITLNKKVKRVESEGAVSDDSLDGSSLRQQQIVFRGKKPRLVKKEEAVSCDLLEDDSLLRHWNLSRNRRAKFIERENAESEDAEEDFTHQQQRSNLRGRHHKYIEEDDEVSGDLHNESSLKQYRRTPRSLQAKFLDGENGVSDDEQEEISHKLHRRIPRGKQIKSSKRNTAVSDDSLKQYRRMRKGKQTKVFERDDAMSDYASDDDSQYQIRRIPRGKQMKCMERYDAFSDDSVEDNSQQQHRRILSSKAAKFTERRRVHRSQLTEFIETEDAVSSDSPDDNSSLRQPRRIPRSKQPEILEREDAISDDSLDGSHQSNRSLRNRKKKGPTLCQMKRETAQNVKQVKRRSTEQVISQRVKQETPQNRNTKTKQTARHCSSSSDEDEIEGGPSTRLRKRTRKPLKQPETKPKEKKQAGKKKVKNALNSKTLSGQNSAKVRDEEVEYQCDMEGCSMSFGSKQALILHKRNICPVKGCGKKFFSHKYLVQHRRVHLDDRPLKCPWKGCKMTFKWAWARTEHIRVHTGARPYVCGEEGCGQTFRFVSDFSRHKRKTGHSGKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MAV6</accession>
    <name>A0A0D2MAV6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G141300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Proteoglycan that seems to be implicated in diverse developmental roles such as differentiation, cell-cell recognition, embryogenesis and programmed cell death.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the classical AGP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MAV6"/>
    <dbReference type="STRING" id="29730.A0A0D2MAV6"/>
    <dbReference type="Gramene" id="KJB14742">
        <property type="protein sequence ID" value="KJB14742"/>
        <property type="gene ID" value="B456_002G141300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785285"/>
    <dbReference type="eggNOG" id="ENOG502S1Y6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FALRITM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044959">
        <property type="entry name" value="AGP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36321:SF2">
        <property type="entry name" value="CLASSICAL ARABINOGALACTAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36321">
        <property type="entry name" value="CLASSICAL ARABINOGALACTAN PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0654">Proteoglycan</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002258647" evidence="12">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="21"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB14742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="141" mass="13352" checksum="25ECFC24AACBFF5B" modified="2015-04-29" version="1">MAKTFACFVLLALIVSCALGQAPSSAPTKSPPSSNPTPAPKVSPTMSPTTTPTASPPSTSTPPSSAPESSPTSSPTTSPPAPPAGSPAGSPSGSPASAVSPTNSISDTPGSSPTSPTSAAALNRVTVAGSAVAVVFAALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N028</accession>
    <name>A0A0D2N028_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TLDc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G186600</name>
        <name evidence="3" type="ORF">Gorai_015088</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Zhang D."/>
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    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <text>1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = ethene + L-dehydroascorbate + hydrogen cyanide + CO2 + 2 H2O</text>
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        <text evidence="1 10">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler B.E."/>
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                <person name="Stelly D.M."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
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                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="421" mass="47662" checksum="FE1BDC706D37DB1A" modified="2015-04-29" version="1">MATQVKMENVDRISNLPDSILGYILSFLSTKEAVATSLLSSKWRYLFALVSNLDFELDESSQMLKISTIKSFMCFVDRVLFFHNTSNINAFRLRCGKRVDSDRVYGWISAAIWRGVKHLGLSISLDNFTLPGVLFTCTTLITLKLKTNLVLNVPKDVCLPNLKILHLKSIMFPNDDSVESLVSSCISLVELIICNCSTKKCNISHNSLKVLEIIRSVLYGSLVIDTPALAYFNYTYSVAREYSLKNLQSLIRADIAFLDIRFDSHQTKATAFFEGISNVNILVLSSPSLKLLKCCEPLPIFPKLLHLNLYCDYLNFERGVANLLTDSGRLQSLFFYQEALTNLPERVPHCILYQLKVIEISGFMTNKDCIGKAKYFLENATVLMKLIIRTVPFLSEEQKSRIYQQLMASPSKSKQCCILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NMD5</accession>
    <name>A0A0D2NMD5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G127400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NMD5"/>
    <dbReference type="Gramene" id="KJB14483">
        <property type="protein sequence ID" value="KJB14483"/>
        <property type="gene ID" value="B456_002G127400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787238"/>
    <dbReference type="OrthoDB" id="1002420at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265509" evidence="2">
        <location>
            <begin position="25"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB14483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="10117" checksum="AAE09C5A6D8E4F81" modified="2015-04-29" version="1">MAKIALVIVLISMIVLVSIHSVVGDTAATSPTASTESNAAKAEAPGHEGHDNSNESWTDWAKDKISGIGGMFASSPSSEPASEPAPTPASSSAETPEVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NNE6</accession>
    <name>A0A0D2NNE6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B456_002G149600</name>
        <name evidence="26" type="ORF">Gorai_022959</name>
    </gene>
    <organism evidence="25 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="26 28" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">8</strain>
            <tissue evidence="26">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="26" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="26">8</strain>
            <tissue evidence="26">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RLP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0580754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NNE6"/>
    <dbReference type="STRING" id="29730.A0A0D2NNE6"/>
    <dbReference type="Gramene" id="KJB14928">
        <property type="protein sequence ID" value="KJB14928"/>
        <property type="gene ID" value="B456_002G149600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785376"/>
    <dbReference type="eggNOG" id="ENOG502QRF2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPECHGS"/>
    <dbReference type="OrthoDB" id="1371922at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000291">
        <property type="entry name" value="Brassinosteroid LRR receptor kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000150">
        <property type="entry name" value="serine/threonine-protein kinase BRI1-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045381">
        <property type="entry name" value="BRI1_island_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27000:SF800">
        <property type="entry name" value="OS11G0197000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20141">
        <property type="entry name" value="Island"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 23" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="23">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033219955" description="non-specific serine/threonine protein kinase" evidence="23">
        <location>
            <begin position="33"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="799"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="882"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="911"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJB14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="MBA0580754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1194" mass="130233" checksum="D8BC8A3F7711CDFC" modified="2015-04-29" version="1">MRPSLASTTYFSLLILTFTVTFLISLEAAASASSKNRDSQLLLKFKASLLDPSLLQSWVANQDPCSFKGVTCQDSKVSSINLSYTALSTEFHIVAAFLLSLQNLESLSLLKANISGNISLPSGSKCSSLLTTLDLSQNTLSGPLSTVSNLGSCTNLKVLNLSSNSLEFSRKESRGLKLSLEALDLSFNKLSGGNVVPWILYGGCSELKLLALKGNKISGEINVSNCGRLQFLDFSSNNFSMGTPSFGDCLALEHLDVSTNKLSGDISHAISSCVNLKFLNLSNNQFSGTIPALPTSKLRRLYLTSNKFEGEIPVYLTEGCSGLVELDLSSNKLSGMVPSGFGSCSSMESFHVSSNNFTGELPIEIFQNMSSLKELDLAFNYFSGPLPESLSSLSNLTVLDLSSNNFSGSIPAFLCENPTNRLKVLYLQNNILTGSIPPTLSNCSQLVSLHLSFNYLTGTIPLSLGSLSNLKDLKLWMNQLHGEIPQQLGNIQTLETLILDFNELTGTMPSGLSNCTKLNWISLSNNRLTGEIPAWLGKLSILAILKLSNNSFYGRIPLELGDCKSLIWLDLNTNNLNGTIPPMLFKQSGKIAVNFIAGKRFTYIKNDGSPECHGSGNLLEFAGIREQQLDRISARNPCNFTTRVYGGLTQPTFNNNGSMIFLDLSYNLLSGTIPNEIGTMPYLFILNLGHNNISGTIPQDIGKLKGLGILDLSYNRLEGSIPQSLTGITMLSEIHLSNNLLSGMIPEMGQLLTFPANDFLNNSGLCGVPLAACGRDRSASSNAEHREPHNRKATLAESVGMGLLVSLFCILGLIVAVIETKKRRKKGNALDVHMDSHSHSGSVNTSWKLTGAREALSINLATFEKPLWRLTFADLLEATNGFHDDSLIGSGGFGDVYKAQLKDRSIVAIKKLIHISGQGDREFTAEMETIGKIKHRNLVPLLGYCKVGEERLLVYEYMRYGSLEDVLHDQKKSGIKLNWAARRKIAIGAARGLAFLHHNCTPHIIHRDMKSSNVLLDENLEARISDFGMARLMSAMDTHLSVSTLAGTPGYVPPEYYQSFRCSAKGDVYSYGVVLLELLTGKRPTDSVDFGDNNLVGWVKQHAKLKISDIFDLELMKEEPSLEIELLQHLNVACACLDDRPWRRPTMIQVMAKFKEIQAGSGLESQSTIATDDGGFSAVEMVGMTIKEIPEGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQB2</accession>
    <name>A0A0D2NQB2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G195800</name>
        <name evidence="9" type="ORF">Gorai_023277</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Choline transporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000002">
        <property type="protein sequence ID" value="MBA0581086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQB2"/>
    <dbReference type="STRING" id="29730.A0A0D2NQB2"/>
    <dbReference type="Gramene" id="KJB15778">
        <property type="protein sequence ID" value="KJB15778"/>
        <property type="gene ID" value="B456_002G195800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785897"/>
    <dbReference type="eggNOG" id="KOG1362">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFVCYLE"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF98">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB15778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0581086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="558" mass="62285" checksum="B41E49A8B651E939" modified="2015-04-29" version="1">MGSTEEDTTTSKPTSLYDAASSTEPLLFKPTTGSAYPSPPIEEPPQSGPSESDPTQSLQISFNYGPRPFKDLPFLILFLLFVLCTFAFGIFSIFHRNDNYSNVSAFTYDFNSTSCVQDTSFLSSQLWVSETSFFALSSSSLWTYLVWTLVITSVLSVPLCLLLLLLLKHYTKQIVYVLLPFFIIMPVFFDVYWFVACSLSSSCSDAFPLVYRILVLVFILLIVGVIVWIIVANWHRIELTVRIIGVASDALSRNLGLFLVMPLLTVGLLAYYASIVVFLVFSRFNGKIVAKESNGEYTCVWKQDSWVPAYFTLAILTMLWSLTSMVEAQVYVTSGTIAQWYFSKDDTKPHRSIRRSLRNAFGPSSGTICLSGLLVFVVRVVRAAVDSAREDVPGIVNLVLRCCVNALMSAIDFLNKFTINFAAITGEAYCTSARMTYELLRRNLLSAVFVETVSTRLLAGVIFVLSSVYAIAVCAILKGVSDLGVNMYTVAALAWVLLILVLGFFVHVLDNVIDTVYICYAIDKDRGEVYKHEVHDVYFQLPISRNSRSSYPSRTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NRC6</accession>
    <name>A0A0D2NRC6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="28">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">B456_002G219400</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2NRC6"/>
    <dbReference type="Gramene" id="KJB16247">
        <property type="protein sequence ID" value="KJB16247"/>
        <property type="gene ID" value="B456_002G219400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB16248">
        <property type="protein sequence ID" value="KJB16248"/>
        <property type="gene ID" value="B456_002G219400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786130"/>
    <dbReference type="eggNOG" id="KOG0368">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000043">
        <property type="entry name" value="acetyl-CoA carboxylase 1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="13 22" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 22" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="25">
        <location>
            <begin position="47"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="24">
        <location>
            <begin position="200"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="23">
        <location>
            <begin position="681"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="26">
        <location>
            <begin position="1505"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="27">
        <location>
            <begin position="1848"/>
            <end position="2163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="KJB16248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="2268" mass="252659" checksum="008940C03FA42F99" modified="2015-04-29" version="1">MLEAQRSAMAGVGRGNNGYMNGVLPIRSPATISEVDEFCYALGGKKPIHSILIANNGMAAVKFIRSIRTWAYETFGTEKAILLVAMATPEDMRINAEHIRIADQFVEVPGGTNNNNYANVQLIVEMAEITHVDAVWPGWGHASENPELPDALNAKGIVFLGPPSVSMAALGDKIGSSLIAQAADVPTLPWSGSHVKIPADSCLVSIPDEIYSKACVYTTEEAIASCQVVGYPAMIKASWGGGGKGIRKVHNDDEVRALFKQVQGEVPGSPIFIMKVASQSRHLEVQLLCDQYGNVAALHSRDCSVQRRHQKIIEEGPITVAPLETVKKLEQAARRLAKSVNYVGAATVEYLYSMETGEYYFLELNPRLQVEHPVTEWIAEVNLPAAQVAVGMGIPLWQIPEIRRFYGMEHGAGYDAWRKTSVVATSFDFDKAESTRPKGHCVAVRVTSEDPDDGFKPTSGKVQELSFKSKPNVWAYFSVKSGGGIHEFSDSQFGHVFAFGESRALAIANMVLGLKEIQIRGEIRTNVDYTIDLLHASDYRENKIHTGWLDSRIAMRVRAERPPWYLSVVGGALYKASASSAAMVSDYIGYLEKGQIPPKHISLVHSQVSLNIEGSKYTIDMVRGGQGSYRLKMNQSEIEAEIHTLRDGGLLMQLDGNSHVIYAEEEAAGTRLLIDGRTCLLQNDHDPSKLVAETPCKLLRFLVSDGSRIDADTPYAEVEVMKMCMPLLSPASGIIQIKISEGQALQAGELIARLDLDDPSAVRKAEPFHGSFPVLGPPTAISGKVHQRCAASINAARMILAGYEHNIDEVVQSLLNCLDSPELPFLQWQECMSVLAARLPKNLKNELESKYKGFETISCSMNVDFPAKLLKGVLELHLSTCPEKERGSLERLIEPLMSLVKSYEGGRESHARVIVRSLFEEYLSVEELFSDNIQADVIERLRLQYKKDLLKVVDIVLSHQGVKSKNKLIFRLLEQLVYPNPAAYRDQLIRFSALNHTSYSELALKASQLLEQTKLSELRSSIARSLSELEMFTEDGETMDTPKRKSAINERMEALVGAPLAVEDALVGLFDHSDHTLQRRVVETYVRRLYQPYLVKGSVRMQWHRSGLIASWEFLEEHIESKNVSEDQMSDEPLVEKHRERKWGAMVIIKSLQFLPAIISATLRETTPNLHEETSNGSLEPTTSGNMMHIALVGINNQMSLLQDSGDEDQAQERINKLAKILKDKEVGSSLRSAGVRVISCIIQRDEGRTPMRHSFHWSTEKLYYEEEPLLRHLEPPLSIYLELDKLKGYQNIQYTPSRDRQWHLYTVMDKPVPIQRMFLRTLVRQPTSDDGLTAYRGLDVDMMRSQSAMSFTSRSILRSLMGAMEELEINMHNATLKSDHAHMYLCILREQQINDLVPYPKRVDLDAGQEEAGVESILEELAQELHAFVGVRMHKLGVCEWEVKLWMASSGQANGAWRIVVTNVTGQTCTLHIYRELEDTSKHRVVYHSLSVRGPLHGVPVNAQYQALGVLDRKRLLARKNNTTYCYDFPLAFETALQQSWASQFPGIKRPKDKLLPKVMELVFADQKGNWGTPLVPIERQPGLNDVGMVAWCMEMFTPEFPSGRTILVVANDVTFKAGSFGPREDAFFLAVTDLACSKKLPLIYLAANSGARIGVAEEVKACFKVGWSNESSPERGFQYVYLTPEDYTKIGSSVIAHEMKLASGESRWVIDTIVGKEDGLGVENLTGSGAIAGAYSRAYKETFTLTYVTGRTVGIGAYLARLGMRCIQRLDQPIILTGFSALNKLLGREVYSSHMQLGGPKIMATNGVVHLTVSDDLEGVSAILNWLSCIPPHIGGPLPILNPSDPPERLVEYLPENSCDPRAAISGALDSSGNWKGGIFDRDSFVETLEGWARTVVTGRAKLGGIPVGIVAVETQTVMQVIPADPGQLDSHERVVPQAGQVWFPDSATKTAQAIMDFNREELPLFILANWRGFSGGQRDLFEGILQAGSTIVENLRTYKQPVFVYIPMMGELRGGAWVVVDSRINSDHIEMYAERTAKGNVLEPEGMIEIKFRTKELLECMGRLDQQLINMKAKLQEAKSNGAHAQMDSLQQQIRSREKQLLPVYTQIATKFAELHDTSLRMAAKGVIKEVVDWDRSRSFFYRRLRRRIAESSLVKIVKDAAGDQLLHKSAMDLIKKWFLDSSVAKGREDVWVNDEAFFSWKDDLGNYSEKLQELRVQKVLLQLMNIGNSSSDIQTLPQGLAALLSKMEPSSRKQMVDELRKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P196</accession>
    <name>A0A0D2P196_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_007G014700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P196"/>
    <dbReference type="STRING" id="29730.A0A0D2P196"/>
    <dbReference type="Gramene" id="KJB39462">
        <property type="protein sequence ID" value="KJB39462"/>
        <property type="gene ID" value="B456_007G014700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801823"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PECGHCF"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046948">
        <property type="entry name" value="ATL20-22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279:SF10">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46279">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249040" description="RING-type E3 ubiquitin transferase" evidence="17">
        <location>
            <begin position="19"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB39462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="372" mass="41284" checksum="183BF974962F3F5E" modified="2015-04-29" version="1">MDILKLFFIIVYFSLHSATSTMDPCTESVCQSTKSSPLIRFPFRLIGRQPKSCGFPGFDLSCNYKSTQTLLQLPYSGNFTIEAIDYGAQQIWVNDPNNCLPRRILSLNFSGSPFTAVYDQDYTFFNCTLDYSRYGLNLIGCLSGDNYTVFATLSNEVVDSLSLSTCRRVATVSVPVGWPFYGGVSSSNLTDDLWLTWSNPKCRKCESRGAKCGLKPNSTNEISCSSASGRGIPRSAQYAITVGAAIPTLLSISCLICYICSKVRSYVAPQRPIPEFNPTVTPQPMLVVGLDGSTIESYPRIVLGESRRLPKPDDNTCPICLSEYRPNETLRSIPHCQHCFHADCIDEWLRLNATCPICRKSPEMSYPPTQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P1G7</accession>
    <name>A0A0D2P1G7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_003G146400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P1G7"/>
    <dbReference type="Gramene" id="KJB20383">
        <property type="protein sequence ID" value="KJB20383"/>
        <property type="gene ID" value="B456_003G146400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789000"/>
    <dbReference type="eggNOG" id="KOG0698">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKRSVIM"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000044">
        <property type="entry name" value="probable protein phosphatase 2C 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF853">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="14">
        <location>
            <begin position="137"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="38"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB20383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="393" mass="42033" checksum="F002C5AE4057BA76" modified="2015-04-29" version="1">MSCSVAVSNSPAFSPSSSLFLNKTPIISPSTEALNLTLTHLKTSSPASPSPSPSSPFRLRLPKPPPVSLLSSSSASNSSPSSGSGSAPGLGSGPVSTVLKRKRPARLEIPVATEAMSLGIPATPCEVGKELEREGDGYSVYCKRGRREAMEDRFSASVELQGDTKQAIFGIFDGHGGAKAAEFAAQKLEKNILDQVITRRDKTAVLDAVKQGYLKTDAEFFTEDNAGGTCCLTALIQNGDLVVSNAGDCRAVLSRSGTAEPLTSDHRPSREDERSRIQNLGGYVDLCRGVWRIQGSLAVSRGIGDRHLKQWVIAEPETKIVSIKPDCEFLILASDGLWDKVSNQEAVDIVRPSFIGTDKPNLLFACKKLVDLSVSRGSFDDISVMLVQLGYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P486</accession>
    <name>A0A0D2P486_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PTC1-like winged helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G068100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P486"/>
    <dbReference type="STRING" id="29730.A0A0D2P486"/>
    <dbReference type="Gramene" id="KJB40525">
        <property type="protein sequence ID" value="KJB40525"/>
        <property type="gene ID" value="B456_007G068100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40526">
        <property type="protein sequence ID" value="KJB40526"/>
        <property type="gene ID" value="B456_007G068100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40527">
        <property type="protein sequence ID" value="KJB40527"/>
        <property type="gene ID" value="B456_007G068100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802348"/>
    <dbReference type="eggNOG" id="ENOG502QU7N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="515863at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051177">
        <property type="term" value="P:meiotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044221">
        <property type="entry name" value="DYAD/AMEIOTIC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059080">
        <property type="entry name" value="WHD_PTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46740:SF1">
        <property type="entry name" value="DYAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46740">
        <property type="entry name" value="PROTEIN DYAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25874">
        <property type="entry name" value="WHD_plant_repro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTC1-like winged helix-turn-helix" evidence="3">
        <location>
            <begin position="92"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB40527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="453" mass="51376" checksum="0626D05E21013E0E" modified="2015-04-29" version="1">MAERGVCRQVKFLNSQGDSTAKPLPGKIEEEYDEDDKKHVKTMLISCPEVRKRKCLSSNQLRKEKAARCGKQSLSNGPNKGKQNKHKNTVERWSAERYNLAEESMLEIMKAEGAVFENPISRPALRMAARKLIGDTGLLDHLLKHIDGKVAPGGTDRFRRCYNTSGVMEYWLENADLVNKQKEAGISPFWQKPVAAPNHVSAGAIEFNLLNEEMVKLKREMQELVSKQQEQDQANSIEEMQKEMLKWKAKTDERLMEFTSSLNGMQNMCKELMTWKTRVEQQMLEISNSLSTLQASKQCTIFSPSASERWEDWLESTNLDNFQGGNLSPWIDNPELINFGQDAVQETDLAPLAWPRPGHSPFEGPFCAQDLDMINEEMAKIMSNVEELAPRRQGEDQANVTPDSSVTANSKSDLDNLLLVQEMLKDLVKWKAKIKQQLTDISSAVSVLQKSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P5E4</accession>
    <name>A0A0D2P5E4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YTH domain-containing family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G020600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the YTHDF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P5E4"/>
    <dbReference type="STRING" id="29730.A0A0D2P5E4"/>
    <dbReference type="Gramene" id="KJB21908">
        <property type="protein sequence ID" value="KJB21908"/>
        <property type="gene ID" value="B456_004G020600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790132"/>
    <dbReference type="eggNOG" id="KOG1901">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="306690at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.590.10:FF:000001">
        <property type="entry name" value="YTH domain family 1, isoform CRA_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF99">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN ECT2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="YTH" evidence="6">
        <location>
            <begin position="454"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="627"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB21908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="670" mass="73974" checksum="F4A62D423A6AFA75" modified="2015-04-29" version="1">MAPTVAPPADQTAELLQKLTIDSQAKPFDIPEPTKKPSVYQYGSVDSGNTGNTQIPTFDRSTTPLLQDFMDPNMCYIPSGYPSAYYYGGFDGTGNEWDEYSQYLNPDGVDMTSGVYGDNGSLMYHHGYSYAPYGPYSPAASPVPTLGNDGQLYGPQHYQYPPFFQPMTLTSGPFTPNPAAPSHGELLTSAAADQKPLPVETPNSNSNGVANGGSVKGNNGPGAIKPSYPSSFNTNNSYGRGPPPGSVPTSGYQDPRYGFDGFRSPIPWLDGSMFSDGQHRPVSSPAMNSLVSKANGFPSSRNQNFRSNSNYMGLHHPGPMSGMGTTHGYVNRMYPNKPYGQYGTTFRSGMGFGSNGYDLRTNERGWLADNKYRPRGRGNGYFGSGNDIMDGFNELNRGPRAKGPKNQKGATPITASTKGQNIPSDGTKDEEKAYVVPDREQYNLEEFLVDYDDAKFFVIKSYSEDDVHKSIKYNVWASTPNGNKKLDAAYQEAQQKSGHCPIFLFFSVNTSGQFVGIAEMVGAVDFQKNVEFWQQDKWTGCFPVRWLIIKDVPNNSLKHITLENNENKPVTNSRDTQEIKLDQGLKLLKIFKEHSSKTCILDDFEFYEIRQKAIQEKKAKHQLQKQVWEEKPGDEKKDIATTNGDLIKEINPIPHSNGLLSEDGSGYPKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P673</accession>
    <name>A0A0D2P673_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBZ4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G034500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P673"/>
    <dbReference type="STRING" id="29730.A0A0D2P673"/>
    <dbReference type="Gramene" id="KJB22193">
        <property type="protein sequence ID" value="KJB22193"/>
        <property type="gene ID" value="B456_004G034500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790262"/>
    <dbReference type="eggNOG" id="ENOG502QS2C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HSIANHR"/>
    <dbReference type="OrthoDB" id="1929441at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35767:SF1">
        <property type="entry name" value="HAPLESS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138678" checksum="B218E8BE44C88C37" modified="2015-04-29" version="1">MLSIENPSSDPSCSPQFTGSDDEVDLLKQPSLDHHHHKNPLPNFSIRDYVFNGRSKDINRNWPFSSESLQLVLKHGMKDPLPPFQHLDIVRNQPKETHVVETNPIEKQRSTRHGVLDSYDIDSVLVDKQSISVEEGSSAQVKAVVALKSQKTEKTTKPSGKKCRLIVKFGGHSDCSSTEDIASNCSVVSESMGSKVCPVCKSFSSSSNTTLNAHIDQCLSVESTPKWTVDSKLTRHKIKPRKTKLLVDVYATAKSYTLEELDRRNGRSWALASNISDFEGLEMCDEGKKKRTYSQNNGEGTVDLGAVYVDANGTKVRILSKVNDVPVLVPLPPVSKHGDDLGPSYKSLKIGKGSKKKRCHALKHHKYLKHAPQCRKNCSHKTPSSMIVGGREGYREEEDSCKRVELCVSKQIKSNDTRNFKESVCYKQEGLSRTPNNQEKTGDLRFQSDQSHEGGRVMERNCVRKLKHSSKNPFSSPRKCARIEKPVYEAPVICRKERSLGMKRVRSALFQASMQNKVEKLLHQREQNAKQSISEDRPCLDDDHTMRSLNNENCTSSLSEMMVDIDANSNPDSPIADTTTTISHQFSAPKCFSFSLQKKKISASSRSSMVESGSNLVKKHSTRENQLHFMAEIDEAIARDYEADQECKLVHDDAKNQREGNEITEELPSEPHSYYHDETENMYSSTGGSEDILDKLDGLESVEETITSLSQSLGTKPGKLSNIPNKISDSFQTNEDYTGPLCGGEGLVFPTEPNLVDKPNMFCAEVGLNIIGQAANVGELDSDVAQSNSFLEVDPILIPGQPGSFLPSPRDMGSDDFQGNASTANQIRSSRDQLDLVDGDSSDSPLSVLSTISNSMEARFDLKYEEPLAFLGAPAAMETDRSGYSTAKSDTLVENGVAVEHTRTFEGEKFQVPRISIEKKPFFSKNDDQPCCCQTKERSFQGFALNYHESQLLRRRTMASMMVPAIRMRNGANPGFGPNNLAARPETFSLTSNAELGSEQMVLPVMKPPLGPIPFKGCPDGGVKLSGHGVCDSASPSSSNPVLRLMGKNLMVVNKEEEASMPLGQGQPCAQSDNRNQDEMPFHHAMPPCSMIFSQNPNDLVERTFDAYSTNGYRNRATLATPPQTTLQLPVGLFLDEHRHHSFTTSMEPYKLLPTARCNMEKVSTLDCKDRSEESIVCSKEVIVIDDDPKIESNKTTDIAKRSEVSGDTHGISKPLDRNHSIANHRYPVVIQNNNFHGITSSSFMGTSHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P959</accession>
    <name>A0A0D2P959_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G148100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P959"/>
    <dbReference type="STRING" id="29730.A0A0D2P959"/>
    <dbReference type="Gramene" id="KJB42317">
        <property type="protein sequence ID" value="KJB42317"/>
        <property type="gene ID" value="B456_007G148100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2ZY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VARHEMS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00132">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000029">
        <property type="entry name" value="Elongation factor Ts, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46325:SF39">
        <property type="entry name" value="CRIB DOMAIN-CONTAINING PROTEIN RIC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="233" mass="24998" checksum="703FCDE3C8697D92" modified="2015-04-29" version="1">MSSSNNKMKGLLKGLRYISEIFENEKEPEMQIGLPTDVKHVAHIGWDGPSSVNSAPSWMNEFKSDGRDDDPAKCVSQDGINREGSKGQSSSSVTDMAEVPKSSKRSSTSTKTSKEESTVKEKGDKPSKEKPDKPKHSKKSSKSSSSKEASDGTTKHKKKSKDPNPATDSNSQDPSGVPKKSSRRNKSKESVDGSSRRSKTRDSDIGSDAGSIAGGLDRDERLSNASAFEGGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PIR3</accession>
    <name>A0A0D2PIR3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G343300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PIR3"/>
    <dbReference type="STRING" id="29730.A0A0D2PIR3"/>
    <dbReference type="Gramene" id="KJB45922">
        <property type="protein sequence ID" value="KJB45922"/>
        <property type="gene ID" value="B456_007G343300"/>
    </dbReference>
    <dbReference type="OMA" id="RMENGFW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132">
        <property type="entry name" value="EMB|CAB87627.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34132:SF2">
        <property type="entry name" value="EMB|CAB87627.1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248913" description="Methyltransferase-related protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB45922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="10043" checksum="4FEAB34941819B1E" modified="2015-04-29" version="1">MCPMRFLLVFFSAILAGYFAWRTAVGSSVDADDGVSEDSRTIVAKNEQDFSFKMMVKNGFWVLVDMASGRYLWRNFKALKNNEKLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJ08</accession>
    <name>A0A0D2PJ08_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DYW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_007G344400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJ08"/>
    <dbReference type="Gramene" id="KJB46027">
        <property type="protein sequence ID" value="KJB46027"/>
        <property type="gene ID" value="B456_007G344400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KNWVSTE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000361">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032867">
        <property type="entry name" value="DYW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF471">
        <property type="entry name" value="DYW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14432">
        <property type="entry name" value="DYW_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="204"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="274"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="375"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="508"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="DYW" evidence="4">
        <location>
            <begin position="723"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB46027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="815" mass="91765" checksum="D1B1D632DCEC5A92" modified="2015-04-29" version="1">MPSPNLNTHNFLHKVPFKFLSLHSFSSIKNANFNHLPLDIQRFLSLLHEFSNTLLSVKSIHAQIITNSVSKHQFLSSNLVRSYSELGCLGLARKVFDKIPQPKPILCNSMLNGYLRNQCYKETIELFELMGASDWGFDSYSCNFVLKACMELEDYERGTEIIKRAVDHRVDGDKFLGSSMINFFMKFGDFNSARRVFNQMISRDVVCWNSMIGGYVKGCYYVAAFDLFLEMILCGVRPSAITMVSLVQACGGMRDLELGKRVHGLVLVFGLGTDVLVHTALIDMYSKLGEHERARSVFDIMPAKTLVSWNVIISGYVQNCLVYEAFYLFQKLVLTGGGFDSGTIISLLQSCAQVADLESGKVLHGYIFRKGLDINVILCTALVDLYSKCGALKEATFMFDRMKNRNVITWTAMLVGLAQNGHAEDAIRLFGKMQEEGVTANSTTLVSLVHCCAHLGSLKKGRSVHARLLRYGYAFDVVNRTALIDMYAKCGNINYAERVFEDVSFFKDVISWNSMITGYGMHGQGHKALDLYRRMLEEGLKPNKTTFVSLLSACSHSGLVDQGRSLFLSMESDHNIRANEKHYACYVDLLSRAGHIKEAEVLIKQMPFQSSREVFEALLNGCRMHKNIDIGIKAADYLLSLDATNPGIYIMLSNIYAEARRWDAVDHIRGLMRGRGLKKTPGYSLIEVGKQLHAFFAGEDSHPNSVEIDWILENLKSELEALGYVPDTSCVLRDVDEAMKIKSLWRHSERLAIAFGLLHTPAGSLIRISKNLRVCGDCHTVTKYISKVVKREIIVRDANRFHHFVDGKCSCNDYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJA9</accession>
    <name>A0A0D2PJA9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LOB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G350300</name>
        <name evidence="9" type="ORF">Gorai_020044</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOB domain-containing protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0591366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJA9"/>
    <dbReference type="STRING" id="29730.A0A0D2PJA9"/>
    <dbReference type="Gramene" id="KJB46152">
        <property type="protein sequence ID" value="KJB46152"/>
        <property type="gene ID" value="B456_007G350300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761548"/>
    <dbReference type="eggNOG" id="ENOG502QV43">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FDGGNNY"/>
    <dbReference type="OrthoDB" id="2016447at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004883">
        <property type="entry name" value="LOB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301">
        <property type="entry name" value="LOB DOMAIN-CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31301:SF83">
        <property type="entry name" value="PROTEIN ASYMMETRIC LEAVES 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03195">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50891">
        <property type="entry name" value="LOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LOB" evidence="7">
        <location>
            <begin position="11"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB46152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0591366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="225" mass="24319" checksum="402E207949B638C7" modified="2015-04-29" version="1">MASSSSSLSNSPCAACKFLRRKCQPECVFAPYFPPDQPQKFVNVHKVFGASNVTKLLNELHPSQREDAVNSLAYEADMRLRDPVYGCVGVISLLQHQLRQLQMDLSCAKSELSKYQSLGITGHAGLIAAAAAATATTHQNLGINLIGSGGGGGGGGREHHFHHHQFFPRDHHHHHQQQMLMSFDAGSNCDANLLAMNVSSGIGQLSQFQSPRAAAGDDRRTIHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUR8</accession>
    <name>A0A0D2PUR8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G142400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUR8"/>
    <dbReference type="STRING" id="29730.A0A0D2PUR8"/>
    <dbReference type="Gramene" id="KJB49862">
        <property type="protein sequence ID" value="KJB49862"/>
        <property type="gene ID" value="B456_008G142400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCYLRYL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050254">
        <property type="entry name" value="RNA_pol_beta''_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34995">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34995:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB49862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="152" mass="18024" checksum="514C5787C6D2546F" modified="2015-04-29" version="1" fragment="single">TGHCDFIYSAILHENADLLAKRRRNRFIIPFQLIQDQEKELMLLSHSGISIEIPINGIFRRNSILAFFDDPRYRRKSLGITKYRTLGAHSIVKREDVIEYRGVKKVKPKYQMKVDRFFFIPEEVHILSESSSIMVRNNNYSYIKIKSIKYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PXH5</accession>
    <name>A0A0D2PXH5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G115700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08956">
        <property type="protein sequence ID" value="KJB08956"/>
        <property type="gene ID" value="B456_001G115700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791912"/>
    <dbReference type="eggNOG" id="KOG0065">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HAICAYM"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000179">
        <property type="entry name" value="ABC transporter G family member 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000059">
        <property type="entry name" value="ABC transporter G family member 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013581">
        <property type="entry name" value="PDR_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08370">
        <property type="entry name" value="PDR_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="532"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="572"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="758"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1179"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1209"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1241"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1265"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1292"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1407"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="162"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="833"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB08956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1433" mass="161015" checksum="B2F659BF2A4A4A25" modified="2015-04-29" version="1">MRRSNASDYFEFDTEGGNAESFHRPSNAEVVLQDEEDLMWEAISRLPSMKQGRFAILKRTSSEIEHDTEGERESGTAETIDVTRLDRSRRELVVKKALATDDQDNYKLLSAIKDRLDRVGLEVPKVEVRFQNLNIEANAQIGSRALPNLLNVARDFFERILIGLRILRPNKCRLHILKDISGIVKPGRMTLLLGPPGSGKSTLLLALAGKLDYKSLKVSGDITYNGTNLNEFYVRRTSAYISQTDNHLPELTVRETFDFAARCQGASEGMAGCMKELTKLETENNIRPTPEIDAFMKASSVGGKKHSISTDYILKVLGLDVCSETVVGSDMQRGVSGGQRKRVTTGEMIVGPRKTLFMDEISTGLDSSTTFQIVKCVKNFVHLMEGTVLMGLLQPAPETYELFDNIMFISEGYMVYQGPREDVLEFFESLGFKLPPRKGVADFLQEVTSKKDQAQYWVDPSKPYEFIPVSKMADAFKNSRFGRSLESTLNVPYDKSRIHPSALSKTKYAAPKWELLKSCFAREKLLITRHRFLYIFRTCQVAFVAFVTSTLFFRTRLHPRDENDGNLYLSCLYFGVVHLMFNGFTELPLMIFRLPVFYKQRDNLFHPPWVWSIVSWIIRVPYSVFEAVVWSCVSYFTVGFAPSAGRFFRFLLLKFVVHQMSIGLFRTLAALARDIVVANTFGSAALLIVMLMGGFLMPKDQIKPWWVWATWLSPLQYAQRAISVNEFTATRWKKISATGNNTVGYNVLHSHALPSAGYWYWLGVGVLIGYALLFNIIVTLALAYLNPLGKAPAIVPDDTENSGAENVELESASPSAQGSSKKGMILPFEPLAMTFHNLNYFVDMPAEMSAQGIPETRLQLLSNVSGVFTPGVLTALVGSSGAGKTTLMDVLSGRKTGGYIEGDIKISGYPKVQETFARISGYVEQNDIHSPQVTVEESLWFSSSLRLPKEISKDQKIEFVEEVMRLVELDTLRNAIVGLPGSSGLSTEQRKRLTIAVELVANPSIIFMDEPTSGLDARAAAIVMRTVRNTVDTGRTVVCTIHQPSIDIFEAFDELLLLKRGGRVIYGGKLGVRSQILIDYFQSIDGIPSIPDGYNPATWMLEVTNPAVEQRTDRDFADIYQNSEQYREVEGSITRLSVPPPDSQPLKFSSIYSQDQLSQFLICLKKQSLVYWRSPRYNLVRLVFTMVCALIYGSVFWDVGNQRHTTKGLFMVMGALYSSCIFLGVNNASSVQPIVSIERTVFYRERAAGFYAPISYAAAQGLVELPYILVQTILFGVITYFMINFERTARKFFLYLLFMFLTFTYFTFYGLMAVGLTPSQHTASVLSSAFYSLWNLHSGFLVPKPRIPGWWIWFYYICPVAWSLKGIVSSQLGDVETMIVEPTFKGTVKEYVSTSFGIDVGMMGTTVAVLLGFCILFFSVFALSIKFLNFQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZR1</accession>
    <name>A0A0D2PZR1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphomevalonate kinase</fullName>
            <ecNumber evidence="3">2.7.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G223300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZR1"/>
    <dbReference type="STRING" id="29730.A0A0D2PZR1"/>
    <dbReference type="Gramene" id="KJB51577">
        <property type="protein sequence ID" value="KJB51577"/>
        <property type="gene ID" value="B456_008G223300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764972"/>
    <dbReference type="eggNOG" id="KOG4519">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAYECII"/>
    <dbReference type="OrthoDB" id="10262935at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00099"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004631">
        <property type="term" value="F:phosphomevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000069">
        <property type="entry name" value="Probable phosphomevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016005">
        <property type="entry name" value="Erg8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035102">
        <property type="entry name" value="Phosphomevalonate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01219">
        <property type="entry name" value="Pmev_kin_ERG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31814:SF2">
        <property type="entry name" value="PHOSPHOMEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017288">
        <property type="entry name" value="PMK_GHMP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="180"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="509" mass="55201" checksum="7A51AFA9A69FA992" modified="2015-04-29" version="1">MEVVASAPGKVLMTGGYLILERPNAGIVLSTNARFYAIVKPIHEDVKPESWAWSWTDVKLTSPQLSRESMYKLSQKHLTLQCVSSSESRNPFVENAIQYTVAAAHATFDKNKKEALDKVLLQGLDITILGCNDFYSYRNQIEALGLPLTPEALATLPPFTSITFNSEESNGGNCKPEVAKTGLGSSAAMTTAVVAALLHYLGVVNLSTSSADQHQENKNSTDLDIVHMIAQSAHCIAQGKVGSGFDVSSAVYGSQRYVRFSPEVLSAAQAAVKGMPLEEVIGNILNGKWDHDRTEFSLPPLMTLLLGEPGTGGSSTPSMVGAVKKWQKADPENSQETWRKLADANSELEIQLNMLRKLAKEHWDAYKCVIDNCSRLKPAKWMEGVTEPIKAEVVKVLLKAREVMLEIRNHMRTMGEAAGVPIEPESQTKLLDATMNMEGVLLAGVPGAGGFDAVFAVTFGDSSRNVTNAWSSHNVLALLVREDPQGVCLESGDPRCREITSAVSSVNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZR7</accession>
    <name>A0A0D2PZR7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c assembly protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G165900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZR7"/>
    <dbReference type="STRING" id="29730.A0A0D2PZR7"/>
    <dbReference type="Gramene" id="KJB09786">
        <property type="protein sequence ID" value="KJB09786"/>
        <property type="gene ID" value="B456_001G165900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VQRIFYF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01191">
        <property type="entry name" value="ccmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071:SF1">
        <property type="entry name" value="CYTOCHROME B_B6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="HEME EXPORTER PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c assembly protein" evidence="8">
        <location>
            <begin position="40"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="285" mass="31514" checksum="ADA329EA6F2B923F" modified="2015-04-29" version="1">MPLREQGVPWTSGAKTKQGEFLVGGNPLILGQNDHMSVSLLQPFFLMSKTRSYAKILIGSRLFLTAMAIYLSLRVAPLDLQQGGNSRIPYVHVPAARMSILVYIATAINTFLFLLTKHPLFLRSSGTSIEIGAFFTLFTLVTGGFRGRPMWGTFWVWDARLTSVFISFLIYLGALRFQKLPVEPASISICVGPIDIPIIKSSVNWWNTSHQPGSISRSGTSIHVPMPIPILSNFANFPFSTCILFVLETRLPIPSFLESPLTEEIEAREGIPKPSSLAESFCIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0G1</accession>
    <name>A0A0D2Q0G1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G040700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q2E8</accession>
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        </recommendedName>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <name>Mn(2+)</name>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
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    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Harker D."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <dbReference type="Proteomes" id="UP000032304">
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    <dbReference type="PANTHER" id="PTHR36355">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36355:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB16339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="156" mass="17853" checksum="E40FAE75F26D736C" modified="2015-04-29" version="1">MEAATPNPNDVQVQHVTKKSSDELLRKFAELDDDDGGGNKGAAFTKELRVMVVKRRKRSGFPRSRRESLGHCESPSNNGTTGLVERKWLLPPPATRRSTFLKQLGIGRSQIRAREIRNRSIFGTIEKTWRKTIEGASKVFMEKHYNRHRRLINDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEY5</accession>
    <name>A0A0D2QEY5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartate racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G130200</name>
        <name evidence="4" type="ORF">Gorai_011746</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEY5"/>
    <dbReference type="STRING" id="29730.A0A0D2QEY5"/>
    <dbReference type="Gramene" id="KJB56657">
        <property type="protein sequence ID" value="KJB56657"/>
        <property type="gene ID" value="B456_009G130200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB56658">
        <property type="protein sequence ID" value="KJB56658"/>
        <property type="gene ID" value="B456_009G130200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768072"/>
    <dbReference type="eggNOG" id="ENOG502QU3Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTAHHWF"/>
    <dbReference type="OrthoDB" id="187836at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047661">
        <property type="term" value="F:amino-acid racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004380">
        <property type="entry name" value="Asp_race"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00035">
        <property type="entry name" value="asp_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF7">
        <property type="entry name" value="ASPARTATE-GLUTAMATE RACEMASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198">
        <property type="entry name" value="GLUTAMATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="Aspartate/glutamate racemase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB56657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0594856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36354" checksum="04971F154B1EB261" modified="2015-04-29" version="1">MLDRSLQMSLNCPSYLLVRQRTLCYKRLNPVRAMPPSSVILHTDESGKFPESRKTCNSLIASLSSYDGPLLSAPNTVGILGGLSVDSTLNFLRKLVHLSKENEVKCMPFVVCSDPVLNRELSSLERSLSSLCSRNEPSQSDHTRIVENLRSKRVFLEKSGAHCIVMPCHISHSWHDEVFKGCSVHSLHMAECVARELKEAGLKPLETGSPLRIGVLATDATLKAGFYQEKLQIEGFEVVMPDKATMEHAVIPAIDALNRKDMEGARNLLRIALQVLLVRAVNTVIIASDDMRDVLPRDDPLLKKCIDPMDALARSTIKWAQQAAEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFV6</accession>
    <name>A0A0D2QFV6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 18">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_002G198300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 18"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QFV6"/>
    <dbReference type="STRING" id="29730.A0A0D2QFV6"/>
    <dbReference type="Gramene" id="KJB15826">
        <property type="protein sequence ID" value="KJB15826"/>
        <property type="gene ID" value="B456_002G198300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB15827">
        <property type="protein sequence ID" value="KJB15827"/>
        <property type="gene ID" value="B456_002G198300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785923"/>
    <dbReference type="eggNOG" id="KOG3240">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AQTYSEN"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
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                <person name="Shu S."/>
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                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
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                <person name="Grimwood J."/>
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                <person name="Lee T.H."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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        <property type="protein sequence ID" value="KJB18634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0582124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_003G069000"/>
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        <location>
            <begin position="18"/>
            <end position="220"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB18634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0582124.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="285" mass="33004" checksum="7725D1211136C3AA" modified="2015-04-29" version="1">MENSMTTNGEVETIEKFLDSDEAKISKLVNKIEGLESEKIKLTNENKDMMEQMKKLNHEMDHLQKRDEEMRLEMDEWDEDSSFLESIAARSANLETEVTRLQHDLRTSTREVGEAKKEVIELKKALEEKALVIERLRHEIAELRKEKVKSEKKGRELETKIGILEVRVTEERGKKSRVQEEMKERIDELKKKIEDLEADVAKLSIELKRRKEEKRQCEEKAMGLEFNMLALKDMVDEKTNEAKSGKVKDIGCTDKRLEVPIATVGTVAAIAVVVAVVYRCCRKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
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    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0577961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJ03"/>
    <dbReference type="Gramene" id="KJB07225">
        <property type="protein sequence ID" value="KJB07225"/>
        <property type="gene ID" value="B456_001G009000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770205"/>
    <dbReference type="eggNOG" id="KOG1650">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="1938353at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cation/H_exchanger_TM"/>
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    <dbReference type="InterPro" id="IPR057291">
        <property type="entry name" value="CHX17_2nd"/>
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        <property type="entry name" value="CHX17_C"/>
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    <dbReference type="InterPro" id="IPR050794">
        <property type="entry name" value="CPA2_transporter"/>
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    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
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    <dbReference type="PANTHER" id="PTHR32468">
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR32468:SF17">
        <property type="entry name" value="CATION_H(+) ANTIPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23256">
        <property type="entry name" value="CHX17_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23259">
        <property type="entry name" value="CHX17_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="109"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="281"/>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <end position="381"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="64"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter central" evidence="12">
        <location>
            <begin position="503"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H(+) antiporter C-terminal" evidence="13">
        <location>
            <begin position="644"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF23259"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="791" mass="88133" checksum="53D0BB354315897E" modified="2015-04-29" version="1">MTYNSSSYTTGMDRTARSEEVCLKFPPKVISPGLAALLVQKDKLGKLMDYSGPRLHFQMVVIFVLTQIIHSLLKLLGLPLFISQLLAGILMSPLIFSDEHSLVTISEDSVAVLGSVGALGFMFFMFLSGVKMDLRLTWKSGKLAIAIGLFPVLVSLIFWLMTVKTLHPGGNVFSNKIFHLAVTYSGTSFPVIHSLLSELKILNSELGRLGLSAALIGDMLTLVLTMFSIWVNTGIQKGSKDVLFDVGMAMLYVCILVFVLRPGMKWMVKRTPEAGQIKDTCFYIIILAFMISPRFTALFRVYFLYGPFIFGLAVPEGPPLGSALVEKLDPVVSGLFMPIFATTCGMRFDLSYFKYSTKYAYHQAVGAVVTLIIKFGVSLLLTLLCKMPTRDSFALAFIMISKGIVEIGSYSIMNDSRIISEDIFAHLTIVIIIVASVVPIAVKKLYDPSKKYLCFQKRTIMNSRFNQELRMIGCVHVPGNVNSIINLLNASCPTRECPIALDVLHLVKLSGQATPLFIAHHNQQKASSNNSYSDNVVVAFKQFERDNLGAVSVNFFTAVSPSNLMYEDTCNLAMDRLTSFIILPFHRRWYSDGSIESEDQTLRSLNFDILERAPCSVGILVEGRRNIKGSNSKDTLSPSNSSSYAIAVIFLGGEDDREALALAKRFSQDESVSLTVIHLKAVGSLEFFLAEDERMLDKEMLKDIKESVPLTYIKEHVKDGPETSTFLRSIVKDYQLIIVGRRYRSEDAITLGLEEWCEFREIGIIGDLLSSSDFFGNFSLLIVQQQRKRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMU6</accession>
    <name>A0A0D2QMU6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G093100</name>
        <name evidence="5" type="ORF">Gorai_020864</name>
    </gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2QMU6"/>
    <dbReference type="Gramene" id="KJB08603">
        <property type="protein sequence ID" value="KJB08603"/>
        <property type="gene ID" value="B456_001G093100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08604">
        <property type="protein sequence ID" value="KJB08604"/>
        <property type="gene ID" value="B456_001G093100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08605">
        <property type="protein sequence ID" value="KJB08605"/>
        <property type="gene ID" value="B456_001G093100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08607">
        <property type="protein sequence ID" value="KJB08607"/>
        <property type="gene ID" value="B456_001G093100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTIA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="770890at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43049">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43049:SF1">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1352"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1216"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0578587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1373" mass="154444" checksum="061C6946AA869F54" modified="2015-04-29" version="1">MEGDNLVSSEIPVTKAVEDTEIIADAVKASNGDLPLVEKEETTLDGEFIKVEKEAVEMKDGSNPANPASNQDNESTIERSLSNPGRELLEAQEKTKELELELERVVGALKLSESENRKLKDEVVLAKEKLDEVGKKYEELDLNHKKLQEQIIEAEQRYSLQLSNLQEALQAQETKQKELTEVKEAFDGLNIEIENSRKRMQELEQDLQSSVEEARKFEELHKQSGSHAESETQRALELEKLLETVKLSAKEMEDQMASLREEVKGLYEKVAENQKVEAALQSTTAELSAAQEELALSKSLVSDLEQRLSSKEALINELTEELEQKKASESKAMEDISILEITFAATKEDFQAKVSELEDIKLKLEEEVKARELVEATLKDQEVNVLIAQEELSKVLNEKEALETAIADLNSNAALSKELCNELEEKLKLSDENFSKTDSLLSQALSNNEELEQKLKSLEELHNESGAAAATATQKNLELEDILQASNEAAEDAKSKLRELEARFIAAEQRNVELEQQLNLVELKGFESEKELKESSEKISELTNKLGEVMEEKNQLNNQMQEYQEKINQLESALNQSTTQNLELAEELKVALERSAHHEDRANMSHQRSLELEDLFQTSHSKLEGTDKKVNELELLLEAEKYRIQELEEQISNLEKKCGDAEGESVMYSDKVSKLASELEAFQARTSKLEIALQMANEKEKELTECLNLATDEKKKLEETSQSSNEKLVEAENLVEILRSDLNLTQQKLESIENDLTAVGLRESEVMEKLKSAEEQLEEHVRVLEEAKARNSELQSLHETLTRDSELKLQEVTENFNSKDSETKSLFEKLKTFEDQIKVYEEQVAQAAGQSASSKEELDQSLLKLASLESTNEQLKSKISEFENKALQSSSENELLVQTNIQLKGRIDELQELLNSALSEKESTDQEIASHMSTIKELSDQHTKASELRAEAESRIVEAEAQLHEAIEKYSKKESESNDLIEKLNALEVQIKTYKEQAHEASTIAVSRQVEVEETLSKLKQLESFVEELQTKSAHFEKESGGLAEANFKLTQELAEYESKLGDLEGKLTAALTEKDETAEQLHISKKAIEDLTQKITSEGQSLQSQISSLMEENNLLNETHQSTKKELQSVISQLEEQLKNEKENEESLKSEINNLKAEIAESSLLQTHVKELEEQLVTVEAQLKEEVESVKTAASVREAELTSKLEDHAQKISDRDVINEQVVQLQRDLQLAETTITQQKDADSQKEMDREAALKHSIEELEAKNKEALHLKKQVKELEDKLQEAEAKMKVASSAAEAKDSVEVNSRDIDGLTFSTPTKRKSKKKSEAASVQVASSSSSATHTEASPLTNLKFVFGVALVSAIIGVILGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QN84</accession>
    <name>A0A0D2QN84_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G100800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QN84"/>
    <dbReference type="STRING" id="29730.A0A0D2QN84"/>
    <dbReference type="Gramene" id="KJB08739">
        <property type="protein sequence ID" value="KJB08739"/>
        <property type="gene ID" value="B456_001G100800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB08740">
        <property type="protein sequence ID" value="KJB08740"/>
        <property type="gene ID" value="B456_001G100800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790429"/>
    <dbReference type="eggNOG" id="KOG1534">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KSTYCAN"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB08740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="270" mass="30710" checksum="7EFD96BC9E8E6251" modified="2015-04-29" version="1">MGYAQLVIGPAGSGKSTYCSSLYQHCETLGRSIHIVNLDPAAENFDYPVAMDIRELISLDDVMEELGLGPNGGLIYCMEHLEDNLDDWLNEELDNYLDDDYLVFDCPGQIELFSHVPVLRNFVEHLKRKNFNVCAVYLLDSQFITDVTKYVSGCMASLSAMVQLEVPHINILSKMDLVTNKRDVENYLDPEPHHLLSELNERMAPRFKKLNKSLIELVDEYSMVSFIPLDLRKESSIQYVLAQIDNCIQYGEDADVKIRDFDPDGDGDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRG6</accession>
    <name>A0A0D2QRG6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G107000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRG6"/>
    <dbReference type="Gramene" id="KJB19511">
        <property type="protein sequence ID" value="KJB19511"/>
        <property type="gene ID" value="B456_003G107000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB19511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="75" mass="8683" checksum="0D08AFB94B6D41A1" modified="2015-04-29" version="1">MKFGVLNQGFLRREGKCRYVKCKRAIEATHGQNPQSLHLLGVPRIYRTHCKHLRRESMSNRLRVKIGPTSRRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRN2</accession>
    <name>A0A0D2QRN2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G319400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRN2"/>
    <dbReference type="STRING" id="29730.A0A0D2QRN2"/>
    <dbReference type="Gramene" id="KJB60682">
        <property type="protein sequence ID" value="KJB60682"/>
        <property type="gene ID" value="B456_009G319400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771129"/>
    <dbReference type="eggNOG" id="KOG2977">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000115">
        <property type="entry name" value="Dolichyl-phosphate beta-glucosyltransferase isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="69"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB60682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="335" mass="37911" checksum="A4C7C1C65F5F2670" modified="2015-04-29" version="1">MGVLLTTLEFLASLLLIFLLGFVSVTVLEAYRRRHTNAHVEAPAMFEDPESLKQVPCPDIVDPAEKYLSLIIPAYNEEYRLPGTLNETMNYLQQRAANDKSFSYEVVIVDDGSKDGTKRVAFDFVKKYGVDNVRVILLGKNHGKGEAIRKGMLHSRGELLLMLDADGATKVTDLEKLENQIHAIVRKDYHPGDSAAGEATFRISDIPIVAFGSRAHLEEKALATRKWYRNFLMKGFHLVVLLAAGPGIRDTQCGFKMFTRSAARKLFTNIRLKRWCFDVEIVFLCKWFGIPMLEISVNWSEIPGSKVNPLSIPNMLWELALMSVGYRTRIWKINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZK1</accession>
    <name>A0A0D2QZK1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G000700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZK1"/>
    <dbReference type="STRING" id="29730.A0A0D2QZK1"/>
    <dbReference type="Gramene" id="KJB63472">
        <property type="protein sequence ID" value="KJB63472"/>
        <property type="gene ID" value="B456_010G000700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3005">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEACHKQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF10">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB63472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="316" mass="35264" checksum="4EB2004198EA09C1" modified="2015-04-29" version="1" fragment="single">FEWARQHPQESVAVRQAAATFKSFSGVTNKIKLAYMMLTLPVWQSLNIAVNYFSTKYTNHSASCPSMPEQMKVKFEYKDDCDHLDEYDQVSDTCETVPETVPETVPNEVVIVSADNLHSIIHEACHKQSEHIEEYGRRKPGESSNLGVGNVESLVFIDPPTSKVTSIAKGLTMVIAAECADMSIAGRESLRGMRFTYAVEADEDLQPWVKEKLSTPDEEYEKLGDTCTFGVYHRQPFDVICSPVRTSSSVVTNLSNEQTAEGTNISIIDKEFRIQKQFSAFVAANGPHLPAIESGHAPRKEDFPSFFLKLKISLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0F0</accession>
    <name>A0A0D2R0F0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Auxin-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G276900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0F0"/>
    <dbReference type="STRING" id="29730.A0A0D2R0F0"/>
    <dbReference type="Gramene" id="KJB44873">
        <property type="protein sequence ID" value="KJB44873"/>
        <property type="gene ID" value="B456_007G276900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804640"/>
    <dbReference type="eggNOG" id="ENOG502QPNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="642974at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF103">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="123"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB44873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="254" mass="28181" checksum="D0A7BD6A2C1488D0" modified="2015-04-29" version="1">MTSIMDAERDKYSMINFEETELRLGLPTGIENDNETAKNNGKRGYSDMVDLKLNLSTTKEASVDEAEKMKEKNTAKPPAKAQVVGWPPVRSFRKNIMTVQKNSSDNKGEKTGSGNTINTAVPAAFVKVSMDGAPYLRKVDLKLYKSYQELSDALGKMFSSFTVGNCGGSQGMKDFMNEGKLIDLLNGSEYVPTYEDKDGDWMLIGDVPWEMFVDSCKRLRIMKGSEAIGLAPRAVEKCKEQKLMLASLQNNNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1X4</accession>
    <name>A0A0D2R1X4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G044400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1X4"/>
    <dbReference type="Gramene" id="KJB64352">
        <property type="protein sequence ID" value="KJB64352"/>
        <property type="gene ID" value="B456_010G044400"/>
    </dbReference>
    <dbReference type="OMA" id="WFPVNSK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262310" evidence="2">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB64352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16804" checksum="0A74957074DF909B" modified="2015-04-29" version="1">MLHSTTHTSLSLFLFSCFSSMSEILANSKEENSPQEQQQRSKANNMPRANLNVLPPHPWFPVNSKDDSDIGLESDGYFEEQDSEDKKEEEEIRQLEFQVALTQELANMMIRKLQELRLEVFLIGLENENLKKKLRQLTHNWLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2Z5</accession>
    <name>A0A0D2R2Z5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL33c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">50S ribosomal protein L33, chloroplastic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G320000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2Z5"/>
    <dbReference type="STRING" id="29730.A0A0D2R2Z5"/>
    <dbReference type="Gramene" id="KJB45678">
        <property type="protein sequence ID" value="KJB45678"/>
        <property type="gene ID" value="B456_007G320000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7HT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRRFMAK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_bL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_bL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001764">
        <property type="entry name" value="PRK00504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L33, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB45678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="93" mass="11086" checksum="14AD301CEF794154" modified="2015-04-29" version="1">MEKEKEIGLWENKKQEKLGELKTQRRFMAKSKNVRVTIILEYTSSVRNGFNKESMGISMYITQKNQHNTSNQLELKKFCLYCYKHTIHGEIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF74</accession>
    <name>A0A0D2RF74_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G039400</name>
        <name evidence="3" type="ORF">Gorai_016012</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF74"/>
    <dbReference type="Gramene" id="KJB28271">
        <property type="protein sequence ID" value="KJB28271"/>
        <property type="gene ID" value="B456_005G039400"/>
    </dbReference>
    <dbReference type="OMA" id="GGNPCCK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989289" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB28271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0585228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="66" mass="6875" checksum="9A630FD3FF91C5B1" modified="2015-04-29" version="1">MALTQAKIVLLFIAMMVLISSAAAAVAPQDFIIKPSNLGRKLLATYYSTPSVYAGRNGGGGNPCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHE1</accession>
    <name>A0A0D2RHE1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G053300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHE1"/>
    <dbReference type="STRING" id="29730.A0A0D2RHE1"/>
    <dbReference type="Gramene" id="KJB70011">
        <property type="protein sequence ID" value="KJB70011"/>
        <property type="gene ID" value="B456_011G053300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB70012">
        <property type="protein sequence ID" value="KJB70012"/>
        <property type="gene ID" value="B456_011G053300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DQPACLL"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06610">
        <property type="entry name" value="STKc_OSR1_SPAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000099">
        <property type="entry name" value="Serine/threonine-protein kinase BLUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000208">
        <property type="entry name" value="serine/threonine-protein kinase BLUS1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF24">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="13"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="687" mass="76033" checksum="7155466EEF9D6526" modified="2015-04-29" version="1">MEKKKYPIGPEHYTLYEEVGQGVSASVYRAVCISFNEVVAIKILDFERENCDLNNICREAQTMVLVDHPNVLKSHCSFVNDHNLWVVMPYMSGGSCLHILKAAYPDGFEEVVIATILREVLKGLEYLHHHGHIHRDVKAGNILIDSRGAIKLGDFGVSACIFDSGDRQRMRNTFVGTPCWMAPEVMEQLHGYDFKADIWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDKKFSKSFKQMIASCLVKDPSKRPSAMKLLKHSFFKQARSNDYIARTLLDGLPVLGDRIKALKKKEEDMLAQKKMPDGEKEELSQNEYKRGISGWDFNLEDVKAQASLIQDEDLINYTNQGGCSNYLPSHDGRDKQSECQTSSQATGKEDNDLVHNQPAAPSLAVDPTRSIAKFERSDDDSSSASASHELNVTSLSDNDHVESNLAEKPVLETNGKSSDNLIKPSHQRTTPFSGSTSIPETSVLPIKGESDKQNQQQNISGGNGAAVSTGGEDTISELPSKTSKSQGVNSDDEKAKPPVVQQKGRFKVTSENVDLEKVAPSPILPKSRSMQVLNTNPMVSLAATSDPSLSIPAANHLFPLLQSVLQTNILQREYILNLMKHVCASEPIASRALEGVCAPANGAVTEKSLLELAHDREKELLHEITELQWRLICAQEELQKYKTENAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLY2</accession>
    <name>A0A0D2RLY2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G151600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLY2"/>
    <dbReference type="Gramene" id="KJB30606">
        <property type="protein sequence ID" value="KJB30606"/>
        <property type="gene ID" value="B456_005G151600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRQ9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022228">
        <property type="entry name" value="DUF3755"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14000">
        <property type="entry name" value="FINGER CCCH DOMAIN PROTEIN, PUTATIVE (DUF3755)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14000:SF6">
        <property type="entry name" value="OS02G0631200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12579">
        <property type="entry name" value="DUF3755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="36464" checksum="28F371FAACC64872" modified="2015-04-29" version="1">MKTESNTGFYHHEDGLGSILNRHGISFQPAGIDSSSEMIPMSGYYASLPTILPGNSSVITSSPALIQPGNSSGSSLLLDSISGQKHEAGFAVEWSIDEQYILEDSLEKYKDEPSIMKYIKIAATLPDKTVRDVALRCRWMQRKRRKPEELNAGKKVNSRKGKLVESSLKVNMPSALPQNMAAYPLMMHHLDQNGRMSSEGISGTVIHLLKQNSQAFSQITSNLSAFKLQDNIDLFCHTRNNITAILNDMRDMPGLMSRMPPLPVSINDDLAISILPGATQLMIFSSPSGIHLKPSQDTYRELLRLRLGIYLIYVNYKQFSSCKSIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RM88</accession>
    <name>A0A0D2RM88_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_003G137700</name>
        <name evidence="17" type="ORF">Gorai_024761</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RM88"/>
    <dbReference type="STRING" id="29730.A0A0D2RM88"/>
    <dbReference type="Gramene" id="KJB20195">
        <property type="protein sequence ID" value="KJB20195"/>
        <property type="gene ID" value="B456_003G137700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788899"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTWIPFS"/>
    <dbReference type="OrthoDB" id="640180at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000005">
        <property type="entry name" value="Putative receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000058">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000001">
        <property type="entry name" value="Receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024788">
        <property type="entry name" value="Malectin-like_Carb-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45631">
        <property type="entry name" value="OS07G0107800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12819">
        <property type="entry name" value="Malectin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715571" description="Protein kinase domain-containing protein" evidence="14">
        <location>
            <begin position="25"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="491"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB20195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0582624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="831" mass="91520" checksum="EF7A1A8F3F43FB86" modified="2015-04-29" version="1">MGCKVFGFLCWVSSILCLPLFARGFTPADNYLIDCGSLTNTTLGDRVFMADNLASKLLSASGNIVGNTSKAVTSSDDSPLYQTVRIFTGVSKYTFPISQRGRHWIRLYFYPFVHASYNMSMAKFDVSTENHVLLSSFSVQSLVVKEFSVNVTTNSLAITFSPSENSFAFINALEVVSVPDQLIPDSAGLVESSTGFQGLTWQALETVARVNMGGPTVSSENDTLSRTWVPDQPFLLGKNLATSVSKIKAVKYVDGGSTREIAPNTIYGTCTRMNSMNDSNSNFNVTWEFNVDPGFQYLVRFHFCDIVSEALNLLYFNVFIDSSIIERDFDLSTYLVNVLAAAYYKDYVTGPATSNKIRVSIGPSNIHGTYPDAILNGLEIMKMNNSDGSLSGLGTVNTSSSSSKKRVGAIVGVTAGVACGVLLAGVLFMYCRKQRQLSRQRLSRTWIPFSINGGTSHTMGSKYSKGTTISLISNTNYHVPFLAVQEATNNFDESWVIGIGGFGKVYKGELNDGTKVAVKRGNPQSQQGLAEFQTEIEMLSQFRHRHLVSLIGYCDEKNEMILIYEYMENGTLKSHLYGSGHPSLSWKQRLEICIGAARGLHYLHTGYAKAVIHRDVKSANILLDENLMAKVADFGLSKTGPELDQTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLCARPVIDPTLPREMVNLAEWAMKWQKKGQLEQIIDSSLKGNIRSNSLRKFGETAEKCLADFGVDRPSMGDVLWNLEYALQLQEAVVQGDAEENSTNMIGELSPQINNFSQLDPTGSAKFEVSSVDDLSGVSMSKVFSQLVKSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RMA2</accession>
    <name>A0A0D2RMA2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_005G157800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RMA2"/>
    <dbReference type="STRING" id="29730.A0A0D2RMA2"/>
    <dbReference type="Gramene" id="KJB30736">
        <property type="protein sequence ID" value="KJB30736"/>
        <property type="gene ID" value="B456_005G157800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0389">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NKVMIRN"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000038">
        <property type="entry name" value="Protein CHROMATIN REMODELING 19 isoform A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="199"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="563"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="734" mass="83313" checksum="1D101EC2B0A72C41" modified="2015-04-29" version="1">MKRVFEEISDEEWENHSFKPSRVLKKNPNPPPIESFAFNSQTQASFSDQSSDDCVEIEHLADDSNLEDDVEPEDAGPVNLARRFIVDEDDDDEEDGDGKDGNENAFEELYDIESSEEEQLQEDDVVGKALQKCAKISAELRKELYGSSGASCERYAEVEASSVRIVTQNDIDAACAVVDPEFQPVLKPYQLVGVNFLLLLHSKGIGGAILADEMGLGKTIQAITYLTLLKHLKNDPGPHLIVCPASLLENWERELKKWCPSFSVLQYHGAGRASYSKELGYLSKAGLPPPFNVLLVCYSLFERHSVQQKDDRKILKRWKWSCVLMDEAHALKDKNSYRWKNLMSVARNAKQRLMLTGTPLQNDLHELWSLLEFMMPDLFATEYVDLKKLLNAEDRELIGRMKSILGPFILRRLKSDVMQQLVPKIQQVEYVIMEKHQENAYREAIEEYRTISRARIAKLSEPDLNNIIGVIPRRQISNYFVQFRKIANHPLLVRRIYDDDDVGRFAKRLHSIGVFECTLDRVVEELKNYSDFSIHQLLLRYGITGGKGTLSDEHVMLSAKCQALAELLPSLKRSGHRVLIFSQWTSMLDILEWTLDVIGVTYRRLDGSTQVTDRQTIVDDFNNDTSIFACLLSTRAGGQGLNLTGADTVVIHDMDFNPQIDRQAEDRCHRIGQTRPVTIYRLVTKGTVDENVYEIAKRKLTLDAAVLESGLDVGNEDDTSEKTMGQILSSLLMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RXK1</accession>
    <name>A0A0D2RXK1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isopropylmalate dehydrogenase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G165900</name>
        <name evidence="12" type="ORF">Gorai_001153</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomer of catalytic and regulatory subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RXK1"/>
    <dbReference type="STRING" id="29730.A0A0D2RXK1"/>
    <dbReference type="Gramene" id="KJB36579">
        <property type="protein sequence ID" value="KJB36579"/>
        <property type="gene ID" value="B456_006G165900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799775"/>
    <dbReference type="eggNOG" id="KOG0785">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VRPCRYY"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="10">
        <location>
            <begin position="39"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00065394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB36579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0588039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="370" mass="40775" checksum="B7D8013CA6D9B7BD" modified="2015-04-29" version="1">MATHILRRQVSRILSHASPNSNPTSYFSLARPFSSATDTIRATLFPGDGIGPEIAESVKQVFRTAEVPIEWEEHYVGDQVDPRTQSFLTWESLESVRKNRVGLKGPMATPIGKGHRSLNLTLRKELNLYANVRPCYSLPGYKTRYDDVNLITIRENTEGEYSGLEHQVVRGVVESLKIITRQASLRVAEYAFHYAKTHGRERVSAIHKANIMQKTDGLFLKCCREVAEKYPEITYEEVVIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGEGGIALAEAVHGSAPDIAGKNMANPTALLLSSVSMLRHLNLHDKADRIQEAILSTIAEGKYRTADLGGTSTTTDFTKAICDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S275</accession>
    <name>A0A0D2S275_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G126400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S275"/>
    <dbReference type="STRING" id="29730.A0A0D2S275"/>
    <dbReference type="Gramene" id="KJB35741">
        <property type="protein sequence ID" value="KJB35741"/>
        <property type="gene ID" value="B456_006G126400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSSE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12458">
        <property type="entry name" value="RRM_AtC3H46_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000678">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 53-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056276">
        <property type="entry name" value="AtC3H46-like_PABC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034365">
        <property type="entry name" value="AtC3H46-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24009">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24009:SF11">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 53-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23182">
        <property type="entry name" value="PABC_AtC3H46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="358"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="433"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="580"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="586"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="645"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB35741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="713" mass="78608" checksum="547F3C9F04DE5212" modified="2015-04-29" version="1">MDSYEATRIVFSRIQNLDPENASKIMGYLLIQDHGEKEMIRLAFGPEAHIHSLILKAKSHLGLSISNPPTPSTPSSPSPFSSRPSPLSIPSSSSRLTKGLEIPNPSSPSTTTWPPLNHCPISPSSTSSLSYASIVNGSSNTANGSGSLSSVPSCVNTCNDNELIDDYQFQDHLSFLNDSKPEDLFSPRLDLAMSTTPSGYADSLLHRRSFSVPGLCFGAEDVNSGIGWKPCLYFARGFCKNGTSCRFLHGDCADAAALVGSPSKLNELEQYQELLRSKALQQQQHQQKLASASQLMSGASFQYSKCVNLLLQQQNDSHRSAMAALMMGDELHKFGRCRAERNDFSAMGLGAAINPGSRQIYLTFPADSTFKEEDVSNYFSIYGPVQDVRIPYQQKRMFGFVTFVYPETVKLILAKGNPHFVCDSRVLVKPYKEKGKVQEKKQQQQSERGEYSACSSPSGVDSREPFDLHLGSRMFYNTQEMLLRRKLEEQADLQQAIELQGRRLMNLQLLDLKNHHHSQFQHGFSTASPVPSPTVSRTPNNQALIFPVDGIDQEFPQENGGCPISAVSELAAAINDDKQLEDYKNDNGNSSTKGKANTEESDLPESLDHILPDNLFASPKKSASDHFTVFSTSSAEAVEADDKTGTPPTTSCSNSNPSPANASGLNMASLKTYLLQMPRNHWHVVSQQWRKIDFARWQLSKHIQGRLNPKKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S5F2</accession>
    <name>A0A0D2S5F2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dynamin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G030800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S5F2"/>
    <dbReference type="Gramene" id="KJB78367">
        <property type="protein sequence ID" value="KJB78367"/>
        <property type="gene ID" value="B456_012G030800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0446">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2465">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LEPRCCF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019141">
        <property type="entry name" value="DUF2045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477:SF13">
        <property type="entry name" value="KIAA0930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21477">
        <property type="entry name" value="ZGC:172139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09741">
        <property type="entry name" value="DUF2045"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="1">
        <location>
            <begin position="34"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="211" mass="23006" checksum="5BEE17F68DDB2BCD" modified="2015-04-29" version="1">MVYSGACGKAPLKPTIASKPWQWPSERSCRFLKIVALGSQSDGKSSLLEALLGFRFNVREIEMGTRRPLILQMVHYRSALEPRCCFQVLTETDHCYCVLVNALDGVAFPSEKDTNDSSSSNKVPLRVDTNSMKTKNSKLTLFSGFVSYQMVRDAYDVGSSGFGSLLSMGHSSGKKDRLYMKGPGGRGEVEVAVSGVVGLVISFTSRGLLNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S7Y3</accession>
    <name>A0A0D2S7Y3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G251500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S7Y3"/>
    <dbReference type="STRING" id="29730.A0A0D2S7Y3"/>
    <dbReference type="Gramene" id="KJB59363">
        <property type="protein sequence ID" value="KJB59363"/>
        <property type="gene ID" value="B456_009G251500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTXK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FAYFTMF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133">
        <property type="entry name" value="OS08G0107100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33133:SF51">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB59363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="305" mass="34546" checksum="48B4CD51497D8707" modified="2015-04-29" version="1">MDRGQEEMQFLGLFGIFKESYKIISSWRKLFTNITLALILPLSFIYLVHVQVSSLFSSKLQLDRIPSDTAEYENSSNLISHEALYFLLFNFAYFTMFYFFSLLSTAAVVYTIACIYTAREITFKTIIRVVPKVWKRLIVTFLSIFVAIFIYLVVAAPVLIIWAAISVGQMDAMADAVLAVLVVLFPAGLFYLATIWHLATTLGLAIAVFFILQPAMGLNHMAFKRLVVEGTDMGMANRVVYAIICFLLLSTGILFQLVIQTVVYFVCKSYNHENIDKSALSDHLEVYMLGDYASLKAKDVQLFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S9Q8</accession>
    <name>A0A0D2S9Q8_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">Zinc finger PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G018300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB27955">
        <property type="protein sequence ID" value="KJB27955"/>
        <property type="gene ID" value="B456_005G018300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R2V0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
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        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053192">
        <property type="entry name" value="Vacuole_Formation_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410:SF169">
        <property type="entry name" value="C1 DOMAIN FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410">
        <property type="entry name" value="CYSTEINE/HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="207"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="408"/>
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        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="5">
        <location>
            <begin position="571"/>
            <end position="637"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB27955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="663" mass="75842" checksum="5DCD47E320C1ACA4" modified="2015-04-29" version="1">MEESNNYGHQHPLLLILNQDQLIHNQSGVTHCSRCGEEVSAPCFCCAEHCGFNLHKACAEAPLELNHPFHLGHPLLLMQNPPYSSHLRCVCDFCDKTCKKFIYHCSCKLDFHIKCALFTFNIAENNLKELDHFALQHPLISTENGDEELGDVSKCFGCWEPLAKYTHFSPDCRFNLHEKCAKLPFKLNHKCHHKHPLTLQFNSERLSCKICQVTRRRGFVYGCSPCKFVVHIECVSESLGLVIEDKRHEHPFTLLLRGSSFICDACGIEGSYASYICCTCNIMVHKKCTSLPRIIKSKWHDHRLFHKYFLRIEDFRVLDCIMCNYEVSTDYGSYYCSECGVIFHVKCAMRNRNSYEIVENEDEESADVSSITKVLEWNDAGEATVIEHITHIHHLTLSDRVGEYDNKCCDGCLLPISDSFYYCTQCDFFLHKVCVELPKVKQVWHHPCQASLVLTSNEVFWCVACGYLSKAFAYKCEECKKRTCLRCIIALTPGAHTCVGHKHPIFLYTEKSGGCVACGKNNIEGLLCCKDCDFSVDHRCFSLPITSQHKSDEHLLSLTYYDDNSYSESHFCDVCEERRDPNLWFYHCATCNTSAHVNCVLGKNPFLKPGNIIEVLKDIHEHPATVVKKIYYYPNCSKCGKPCFDLALECTGCNFIVHVMCPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBR5</accession>
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        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">B456_007G004500</name>
        <name evidence="7" type="ORF">Gorai_017646</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds actin. Enhances the F-actin depolymerization activity of actin-depolymerizing factor (ADF) proteins.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB39266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0588867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBR5"/>
    <dbReference type="STRING" id="29730.A0A0D2SBR5"/>
    <dbReference type="Gramene" id="KJB39266">
        <property type="protein sequence ID" value="KJB39266"/>
        <property type="gene ID" value="B456_007G004500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801712"/>
    <dbReference type="eggNOG" id="KOG0318">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FYQGPPF"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="53"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="487"/>
            <end position="519"/>
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    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="530"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="574"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058835"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB39266.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0588867.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="609" mass="65972" checksum="C4A8B3519F532F63" modified="2015-04-29" version="1">MPELAETYACVPSTERGRGILISGDPKSNKVLYTNGRSVIILDLNNPLNVSVYGEHAYPATVARFSPNGEWVASADVSGTVRIWGAYNDHVLKKEFKVLSGRIDDLQWSPDGMRIVACGDGKGKSLVRAFMWDSGTNVGEFDGHSRRVLSCAFKPTRPFRIVTCGEDFLVNFYEGPPFKFKQSHRDHANFVNCVRYSPEGSKFISVSSDKKGIIFDGKTAEKIGELSSEDPHKGSIYAASWSPEGKQVLTVSADKTAKVWDISEDGSGKLKKTLTCSGSGGVDDMLVGCLWQNDHLVTVSLGGTISIFSASNLEKSPLQLSGHMKNITSLAVLKSDPKCVLSSSYDGLIVKWVQGLGYSGKLQRKENSQIKCFAAAEEEIVTSGFDNKIWRISLHGDQCGDGDSVDIGSQPKDLSLALLSPELALVTTDSGVVMLRCTKVVSTINLGFAVTASVVAPDGSEAIVGGQDGKLHVFCIVGDTLKEEAVLERHRGAITVIRYSPDFSMFASGDANREAIVWDRVSREVKLKNMLYHTARINCLAWSPNNSMVATGSLDTCVIIYEVDKPASSRMTIKGAHLGGVYALAFTDEHSVVSSGEDACVRVWKLTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SE08</accession>
    <name>A0A0D2SE08_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B456_013G143700</name>
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    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_013G143700"/>
    </dbReference>
    <dbReference type="OMA" id="DLECEQL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48248">
        <property type="entry name" value="UVR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48248:SF5">
        <property type="entry name" value="UVR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB81407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="91" mass="10777" checksum="669BF2C46DB6A5B5" modified="2015-04-29" version="1">MKKLRVKMEEINEEQKNIRELQGELREKIEAIDLECEQLREETTMVRQQSVNTQIRLALMFQILKARQNHDFAQASHLTSTLRGNISKLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SE51</accession>
    <name>A0A0D2SE51_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G157000</name>
    </gene>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SE51"/>
    <dbReference type="STRING" id="29730.A0A0D2SE51"/>
    <dbReference type="Gramene" id="KJB42534">
        <property type="protein sequence ID" value="KJB42534"/>
        <property type="gene ID" value="B456_007G157000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803317"/>
    <dbReference type="eggNOG" id="ENOG502QSFU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="25620at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241">
        <property type="entry name" value="INTERFERON-INDUCED PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14241:SF32">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="48545" checksum="1208B7B7A7085762" modified="2015-04-29" version="1">MGGETIIPPTSTSEEEYSVDQDFPLPSLTSLNPTLLRDYLRMKAEDGKNESDRLFLEEFDKMGPQSSSPDFEAYHKRRQKVYKEVLQSYDQLRVRSKSLNEAKYKVLSYFPGTWIENVGGKKLSDYDVPKTTSLLLIGPKGCGKSSLVNKISRVLEDDNFAPERAQISYNPSVGDGTYYLQGYMIPRGSASFCLYDSRGLADGTSENINMIQNWMNNGVRHGEPVIRKSDDSSLRRKMKFKPRELDWKFCRPQMVNFVIFVVDAVSVLKSIEGDGVEDLLCLQMISEVFKQPCLSFKDDKPVVVITHGDLLSIADRVRARVYLGELLGIPPAKQIFDIPENHDPVTELTIVDMLRYSLEHADRNLPYKNWVMENVRKVPLFSWLCVLAMLLGIASGMACMRYLHMRHPRESELNIVWHTIRHIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SK22</accession>
    <name>A0A0D2SK22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7733 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G259000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2SK22"/>
    <dbReference type="STRING" id="29730.A0A0D2SK22"/>
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        <property type="gene ID" value="B456_007G259000"/>
    </dbReference>
    <dbReference type="OMA" id="VIVAVDW"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="entry name" value="DUF7733"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7733" evidence="2">
        <location>
            <begin position="2"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="74" mass="8722" checksum="5608615EE4D364E7" modified="2015-04-29" version="1">MVYNTRIFSLVDWLRCEFTKVDNEYAGSGKRVYVGRVLALANMGFWCFNLFGFLLPVYLPKAFKMYYSETKVKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMZ1</accession>
    <name>A0A0D2SMZ1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="15">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G310900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMZ1"/>
    <dbReference type="STRING" id="29730.A0A0D2SMZ1"/>
    <dbReference type="Gramene" id="KJB45539">
        <property type="protein sequence ID" value="KJB45539"/>
        <property type="gene ID" value="B456_007G310900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761168"/>
    <dbReference type="eggNOG" id="KOG2118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Magnesium/cobalt efflux protein CorC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777">
        <property type="entry name" value="HEMOLYSIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22777:SF17">
        <property type="entry name" value="UPF0053 PROTEIN SLL0260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="12">
        <location>
            <begin position="140"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="412"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="613"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="613"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB45539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="73025" checksum="F9B2D1BF0EE6FA50" modified="2015-04-29" version="1">MALESSIFSRPTFIYSTKSSSFMFFNRNLKNQSKFLPKTNHYPTPVISTCSNPQAFKAFGIPKNGSFGHVGSLREENEGVGNDQKLVLVKRGILVAMVCGVLVFGCKRVFAVDGVANAGYGVIGQCILLLRNAWPKASMILKVFKEQGLVLTALLGLSAFFSMAETAITTLWPWKVRELADKDSEDGVFKMLSSDVTRFLTTILIGTTVVNIGATALVTDAATAIFGEAGVTAATGVMTVAILLLTEITPKSIAVHNPTEVARFVVRPVAWLSVILYPVGRVVTYLSMGMLKILGLKGKSEPYVTEDELKLMLRGAELSGAIEEEEQDMIENVLEIKDTHVREVMTPLVDVVAIDASSTLVEFHNLWLTHQYSRVPAFEQRIDNIVGIAYAMDLLDYVPKGELLESTTVGDMAHKPAYFVPDSMSVWNLLREFRIRKVHMAVVLNEYGGTVGIVTLEDVVEEIVGEIFDENDSKEEIQKKTGYIVMRAEGIFDVDANTSIDQLSEDLNIKMPEEHQYETVSGFVCEAFGYIPRTGESVKVELERGNQEEEDENSEAASDRQDLKERRQIYKLEILAGNARKVSAVRFERVNNEEALLDAMSVTPMVPKIMKKWSKDEDSNNGKHNEDTFENKQEDNLLDDHYVIADHKDDNESSNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SRU7</accession>
    <name>A0A0D2SRU7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G265300</name>
        <name evidence="2" type="ORF">Gorai_010514</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
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                <person name="Arick M.A. II"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">8</strain>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
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                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="5">8</strain>
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        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="779250at2759"/>
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        <property type="component" value="Chromosome 8"/>
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        <property type="entry name" value="OS07G0675200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35985:SF1">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB49861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="242" mass="26862" checksum="515A58365CE17CBE" modified="2015-04-29" version="1">MMQFRLATASSRSYLAVFAAQKQGQFRRFASGAAIKGRTADPTIHSGELEAGPDVHRGEPQGIENHPDDHGEKEPKPGSETDPVKQPKLPHESSPRLKSSPVNHPLEPNVQQGRTATSGAALDDVSCVGMDGTPLPESKGKEERGKREETMDDKEYFKHHKASPLSEIEVADTRKPITRATDGTASETEQSKGERIGWRAEQLETAEETLLRATRIWKENAMRGIPEAPHSRRLRELRGEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TFH1</accession>
    <name>A0A0D2TFH1_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G077100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_009G077100"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dr1-associated corepressor homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
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        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF98">
        <property type="entry name" value="TRANSCRIPTION FACTOR CBF_NF-Y_ARCHAEAL HISTONE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="160"/>
        </location>
    </feature>
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        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB55409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
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    </protein>
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        <lineage>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_009G125500"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251782" description="Extensin domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="394"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB56569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJI8</accession>
    <name>A0A0D2TJI8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
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            <taxon>malvids</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_009G046600"/>
    </dbReference>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
    <dbReference type="OMA" id="KRTFHLF"/>
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    </dbReference>
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        </location>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB44715.1"/>
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    </evidence>
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        <source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Lemke C."/>
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                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Dennis E.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Conover J.L."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="2">8</strain>
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        </source>
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        <property type="component" value="Chromosome 12"/>
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009856">
        <property type="entry name" value="Lir1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36762">
        <property type="entry name" value="LIGHT-REGULATED PROTEIN 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36762:SF7">
        <property type="entry name" value="LIGHT-REGULATED PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07207">
        <property type="entry name" value="Lir1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB77073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0601505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14259" checksum="2D5BA9E3A9284907" modified="2015-04-29" version="1">MQAALSLAPSPLSIVTKPLFPPCKSMLKLQTPRGFKATPVGQDNSTVDYSSTASVFPAEACDTLGGEACDVEMFPEVKLKPDQTQSNKGKTGSEQVDREYLEYNSPKTVFIGEACDDLGGEFCEPEYQKGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPI2</accession>
    <name>A0A0D2TPI2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G131800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPI2"/>
    <dbReference type="Gramene" id="KJB56676">
        <property type="protein sequence ID" value="KJB56676"/>
        <property type="gene ID" value="B456_009G131800"/>
    </dbReference>
    <dbReference type="OMA" id="LELPRMF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB56676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="102" mass="11747" checksum="63F1C834022EAD45" modified="2015-04-29" version="1">MSHEKCNAGEQFLTLLELPRMFFPRTLSRDCLQLDGDLAPFKECRLLQTSHLGKERFRSYVNPKQPSDDLFKIGLIMDEVHGFNAGIMMPYFINALGKHCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPV2</accession>
    <name>A0A0D2TPV2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent Clp protease proteolytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G145900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPV2"/>
    <dbReference type="STRING" id="29730.A0A0D2TPV2"/>
    <dbReference type="Gramene" id="KJB77568">
        <property type="protein sequence ID" value="KJB77568"/>
        <property type="gene ID" value="B456_012G145900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0840">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QLMYLEH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009368">
        <property type="term" value="C:endopeptidase Clp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009532">
        <property type="term" value="C:plastid stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000035">
        <property type="entry name" value="ATP-dependent Clp protease proteolytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033135">
        <property type="entry name" value="ClpP_His_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381:SF8">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 6, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00382">
        <property type="entry name" value="CLP_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB77568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="285" mass="30791" checksum="936D5B2BCF7E07BB" modified="2015-04-29" version="1">MVASAVSSSLSLSLYSRTRPTSISSPSSRSSTRLIISALPTPYGDSSTMGLSSRVSGLPLKIDKKGFGDSDLSYGAIEAKKGNPPVMPAVMTPGGPLDLSTVLFRNRIIFIGQPVNSQVAQRVITQLVTLAAIDENADILVYLNCPGGSTYSVLAIYDCMSWIKPKVGTVCFGVAASQGALLLAGGEKGMRYAMPNARIMIHQPQSGCGGHVEDVRRQVNEAVQSRHVISSFVYFAIFRKIDKMYAAFTSQPLEKVQQYTERDRFLSVSEAMEFGLIDGVLETEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQ10</accession>
    <name>A0A0D2TQ10_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein BIG GRAIN 1-like A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_009G144000</name>
        <name evidence="10" type="ORF">Gorai_011861</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
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        <text evidence="1">Involved in auxin transport. Regulator of the auxin signaling pathway.</text>
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        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BIG GRAIN 1 (BG1) plant protein family.</text>
    </comment>
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    </dbReference>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        <source>
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            <dbReference type="EMBL" id="KJB56966.1"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Stelly D.M."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Wang Z."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="675"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1341"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1368"/>
            <end position="1387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1492"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1823"/>
            <end position="1833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB59316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0595806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="2169" mass="237320" checksum="B11D454996A0FFE3" modified="2015-04-29" version="1">MDPPSYIHHHHHHANHPRYVPFSPTPPLHPHRPPPQPLPPYQQSPTNLHPSRHHLPPQIRPPPPPPPLPQQNQQQTYQPLPAPPPPLPRQQYSNHPPYNPHHPQYSSSSNFNSNPKPTHVSHQFHDVPQRRLPEFDTRPDYWPENRVPRPHPVSNLDREALYHQFDRRPASPVIDRFMHDLEGTSRFRDLELNQREREGRVHNDRWISDRSSRDFGIVSIGFESNSNNSRFDHEATENIRWGSRLREPLIESGNDEINERDEMRVFSRKNDYCDPEAERFSDKGSGREGNHEFNRTPRKQIQKKSALLRIQKVKLSHRSREDERPHYLGYHNEGKTGTFRGKDSVLQSDHGMDEKKREGTPVELDVSFKSNSLVAKAIVTSSPASNFDSNLMPRNTKIRKLTTFDMVSSSAQPNKGSESTAKLGGSTSAVKSGSGPVDSKQSEGKIKSSDTGKAQDGIRKPCSKGTKVFLRKGKVKKSPKVTVTEDAPSSDKKLRPLEGKGTTPCIGSKGDGGVETSSNSVNILVGENKVGGTVKSTVSDKTTATVGKSSSLKANKKKIIVRKVVKKVVSSPLNLGNSELAKKGDQLVKTDISIRRASATPVAEKRVLPLKMKVASASGDSVQGVDLECSPEESALILEDDKVNEASKGTGSKKVSTDVDPGSSVSPKITRKKNSSTVALNSSSQGESNVDHGSTNAGNSVPGLHIISNIKEDHTEKPNETITSGSFGVEDLNTRFYHNENNINYGLSRSEDIKAHGGIVDIGSSSVAMPISTGFDCGSSSSLEKNIVCDIGDANSGSRHVCTTPSSPVVDDRAKGGLPEANCSVGSDKMPLLPCMEETYVSGGSVYGDCFNHDKSTTSTPDIVYVNTGERNHEIGYDLVLSLGFSGTGIPNAVESVECRDKYAANIHKRKVGVSELDLSSSALASISVGSADVLTSANCVESTICASEIDLNPAEPMVGAIGLLDVGLEHSRNKDSVLQGSSSNNTFPEIGGSADGKSPEKKKRKISTSSSSLTSPVISQSVVVSDIFKSAAQIPSNFTDDLLQLEPEVKVSSIDDLHAEGIDLLHVNSSVAGPSEDVGSFSDACRGNPPKIDPSAFAESVAPSSPCLHPLELGGEQFSNGTPVSAISNHQSDAMDIEGDDRGKVLVDTSEEQNIISSELTQCRIIPEHVSFGLDKRFAGIDADDDNHLPLKDDLPSTSNSLISGVDANEVSATNSNDEAMPAPDILCDVGSLSNLVLSTSTCKGHLFNSEEKTEKLSYDKPVIEGSCNSSAHVSDPQHSKTILKSKDVIQTNQSSAGKAGLLPSYDSESTISLNFLSGETQGRKPLLSHVGPKSYPTRSSFVSSASKNATSSTKITKPRTWRRTDNSSAHPLSGNKPSLSANPMQKQMPTYIRKGNSLVRKPTPVPAPPQGSHSSSSSVYRLKSGIVDEVKKGTGPNNRADAVDLRTAGANTTFERPTTPPLSSVTKVPKHISNSSGECTYSPLAEPSASDFNETTTNHPSSMEINDELKSPEDGQKTLETLNRNGSANNLEVLNEQNESGLIPSNEKRVTYVKPKSNQLVATSDSDHTSIFDVDKNQSLSASSDGYYKKRKNQLIRTALESHMKQAVTSSDDISNSVREIAAKVISSRTFGKRRSNKVVAKTHKPSKFSLVWTPHSARLSNNDGSSLCYPKVRPQLFPWKRMAHKRSFKLNSVSSYSSSLSTIGRKMLLLRKRNTVYTRSINGFSIHKSKVLSVGGSSLKWSKSIERHSRKANEEATLAVAEAERKKREQSTVSRTGKKGLSCHKVHGTEVRRGERIFRIGSVRYKMDSSRRSLQRISDDASSCSASQQSENSTKKSYVPRRLVIGNDEYVRIGNGNQLVRDPKKRTRVLASEKVRWSLHTARLRLVKKRKYCQFFTRFGKCNKDDGKCPYIHDPSKISVCTKFLKGLCSNPNCKLTHKVIPERMPDCSYFLQGVSFLNYAFLFLILDMQILTELLAGLCTNENCPYRHVHVNPNASTCEGFLRGYCADGNECRKKHSYVCPNFEATGSCPLGSTCKLHHPKNRSKAKKSKRSMEHNTARGRYFGIDISKPKRMVSERQQEVLEEDNICFDGKFSDYISLGVSDDEVGGLHQANCDETSFGDNDSTDLQSEDLDELIKPIRIMSECKITESFLVTESSSGKHLAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TW65</accession>
    <name>A0A0D2TW65_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_008G029900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TW65"/>
    <dbReference type="STRING" id="29730.A0A0D2TW65"/>
    <dbReference type="Gramene" id="KJB47515">
        <property type="protein sequence ID" value="KJB47515"/>
        <property type="gene ID" value="B456_008G029900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1767">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB47515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="133" mass="14964" checksum="CC103B8C0C7DF8BA" modified="2015-04-29" version="1">MAPEKDKAPPPSSKPAKSGGGKQKKSKWSKGKQKEKVNNMVLFDQATYDKLLSEAPKYKLITPSILSDRMRINGSLARKAIRELMARGLISCFGHSAFLDEIDKVLKMSYLWKLRPSNTSFCVNLLDFEETRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXT0</accession>
    <name>A0A0D2TXT0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G305000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXT0"/>
    <dbReference type="Gramene" id="KJB60431">
        <property type="protein sequence ID" value="KJB60431"/>
        <property type="gene ID" value="B456_009G305000"/>
    </dbReference>
    <dbReference type="OMA" id="RYVCKCE"/>
    <dbReference type="OrthoDB" id="997487at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB60431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="155" mass="17713" checksum="7BA0A08CD16E10CD" modified="2015-04-29" version="1">MELILLLVKIIGTVVLVGVSVMFLRLLDALVLTPKRIRSQLQIQPITQSTPPPSLAPNNTQFKGKPVWFNAYVFTEGNTDFAEEASGYGRKWVRQRGYEDDNVVSPGRYVCKCEYGFPKLVSFKKDDEDDLVRASLFTRWLTCLFLPVHIIKFQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXV7</accession>
    <name>A0A0D2TXV7_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G306000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2TXV7"/>
    <dbReference type="Gramene" id="KJB60461">
        <property type="protein sequence ID" value="KJB60461"/>
        <property type="gene ID" value="B456_009G306000"/>
    </dbReference>
    <dbReference type="OMA" id="WQVELIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36374">
        <property type="entry name" value="OS01G0969000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36374:SF1">
        <property type="entry name" value="OS01G0969000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="99" mass="11497" checksum="E3988C4A7DA69E83" modified="2015-04-29" version="1">MARNLEIQIEDKNSKFPKNLWLLLPKLPFNRKRSVEVVIEKKPNGKQLSDEKKIINKPADEVKFSEPRPAVPPPLTLEADQTGRTSNRVILWQDDYPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U087</accession>
    <name>A0A0D2U087_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G416600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U087"/>
    <dbReference type="STRING" id="29730.A0A0D2U087"/>
    <dbReference type="Gramene" id="KJB62429">
        <property type="protein sequence ID" value="KJB62429"/>
        <property type="gene ID" value="B456_009G416600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="192" mass="22459" checksum="F104490B109E9B3A" modified="2015-04-29" version="1">MKRKVRRCHWLFAEIKRRKKGHDWELRPGGMLVQKRDLDISRPPIPPSTIRVRVYKSIYHEIGINSQVTFSKSLTLFYLLILKIHLDENLLCLTRDAKSDSVPDLQQQVVGLKVELCRLLEEKRSAILRSDELEIALMEMVKQDNRRQLCAKANTKRLQPVSGLLSALLVKYPNMLQLAQRAFITYRAMIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3K7</accession>
    <name>A0A0D2U3K7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G151600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_008G151600"/>
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    <dbReference type="KEGG" id="gra:105764181"/>
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    <dbReference type="OrthoDB" id="1026733at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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        <property type="entry name" value="FAF1_2-like_UAS"/>
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        <property type="entry name" value="Thioredoxin-like_sf"/>
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    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
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    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
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    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF71">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED (UBA) PROTEIN-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF21021">
        <property type="entry name" value="FAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBX" evidence="4">
        <location>
            <begin position="311"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
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        </location>
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            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB50020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="392" mass="44778" checksum="FE8B66E346502578" modified="2015-04-29" version="1">MSLTIRGTAKARDQPSCNGFFCRMVCLPKCIFGGFSRVMGRRNQYQPSELQLQHPQLLHPPVVPEDWAFLVSFEQQYGTTHPFFYACSFMQALKIAEDEHKLMFMYLHSPEHPFTPSFCSRTLSSELVVQFLDANFVCWGAIADRGEGLQMAATLQPASFPFCAVIAPAAGNNIAVLQQMEGPIDPAELVEILQRTMEEQGSAFGTTVRGREEEHMRARIKEEERIKARAKEQEKLRADRQLREEQDAAYFVALQRDQEKENLRNARAQKPIEASNQTNYQNPRQMHREKQLGKPRQSSSVGEAQYKETITQGKDTQILIRFPGGERREHNFSCTDKILSIYRYIDSLGLPGIANYRLISSFPRRVYSFDQMGMTLKDAGLHPRASLFVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3T0</accession>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_013G192500"/>
    </dbReference>
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            <begin position="27"/>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="107" mass="12385" checksum="F2B872EA52FF8D97" modified="2015-04-29" version="1">MDNQDVIMAMAVEAALKWNRREKRQMRKLQRAVREKDRERASLKRKKEDMVAKEAAKQKVVDEFMPFFVAIANNDMETAQNFDETAMMNTIRTTLNDGEGHAGHNAD</sequence>
</entry>
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        <lineage>
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            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Harker D."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_013G265500"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ENABLED-LIKE PROTEIN (DUF1635)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33431:SF12">
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        <location>
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        </location>
    </feature>
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        </location>
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            <end position="102"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB83803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="258" mass="28843" checksum="389C3C2FC5ED9E41" modified="2015-04-29" version="1">MEELGSSWNYQEDFDELNLKLQYTIMELENVKMDAIEQTRKHNEETKHLLNLLELAYKERDEAKNQLQNLINKLVPNSQFENPIFLTPKPNSTSITESNSLSDPYHHHNNHNHGDSFIDTVTSPDFSTIKMGFLNQTNVPGITTVDGLTKGKILPQKGKLLQSVMEAGPLLQTLLVAGPLPNWRNPPPPLQALKFPTVSANGGTKLASQDNPNRADMVQKRFNHCSPSVLNFVSSGFSGSQVLNTSGAVKRQKRQKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="9">Uncharacterized protein</fullName>
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        <lineage>
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            <taxon>Gunneridae</taxon>
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    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <dbReference type="KEGG" id="gra:105771490"/>
    <dbReference type="eggNOG" id="KOG0048">
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        <property type="component" value="Chromosome 10"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Transcription factor RAX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48000">
        <property type="entry name" value="OS09G0431300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48000:SF42">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB36-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="9"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="63"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="63"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB65084.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="263" mass="29087" checksum="1D7FF7DF2E02F493" modified="2015-04-29" version="1">MGRAPCCDKANVKRGPWSPDEDDTLRNYLAKHGTGGNWIALPRKAGLKRCGKSCRLRWLNYLRPDIKHGGFTDEEDNIICSLYSSIGSRWSLIAAQLPGRTDNDIKNHWNTKLKKKLFAAKTGVDQNSNNHESTITDSSTTSVPIEAEALVNGSTTTTTSSSYMINMKYQQNYDYPGLVLDQIDQFTLPGLMEYSITSTANDNYSMSSSSQEVSILCNSSSFAPENNSTAWFIDGGAEDQGILLDQLDFEGPHYLFTASGQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF63</accession>
    <name>A0A0D2UF63_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ninja-family protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">ABI-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G027000</name>
        <name evidence="8" type="ORF">Gorai_010954</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Acts as a negative regulator of abscisic acid (ABA) response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the Ninja family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF63"/>
    <dbReference type="STRING" id="29730.A0A0D2UF63"/>
    <dbReference type="Gramene" id="KJB54250">
        <property type="protein sequence ID" value="KJB54250"/>
        <property type="gene ID" value="B456_009G027000"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB54251"/>
        <property type="gene ID" value="B456_009G027000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSTR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVMFGYP"/>
    <dbReference type="OrthoDB" id="1936656at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009867">
        <property type="term" value="P:jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031307">
        <property type="entry name" value="Ninja_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032308">
        <property type="entry name" value="TDBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31413">
        <property type="entry name" value="AFP HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31413:SF12">
        <property type="entry name" value="AFP HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16135">
        <property type="entry name" value="TDBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU369029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB54250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0594032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="488" mass="52327" checksum="5E421E6E42756F67" modified="2015-04-29" version="1">MEDDNGLELSLGLSCGASSAKARGKISSSSDTRTEEGDRGVKIVDNFKNFLQAGNEKQDPSVGSQRSDPIKPSENFFNDLSKGNGEVEATVNLNGRGLWGTNSNRSAEIDEDKRSETGSKRKMLFNEINNPKKLEREAHHTDLHEKSKTSHISLTEDGSTAENEDVAESEVEGSTSRLVSHHDDGSKRFMGVSGSAEVPKEVKLGNLNYGNSFQVQSVNVMNAPFSLPMKDSNSVGIPSSSGHTMPGMMQMMPTGNSERSGTQSVNPGNLPVMFGYLPVQLPLLDKDNPWGMVSHPPQFQASYAGRSPPNADKQSDGLKISQASMHTIARNSSEAAQYDGRTFERVKGEGKQHGVEEGSSTRAEEDVKGSSVNLRANATSDRQTAEALNLDFSAIKPGIAADLKFGGSGSYPNLPWVSTTGTGPHGRTISGVTYRFSTNQIKIVCACHGTHMSPEEFVRHASEECTNPDNNNGLATFPGTNPAASSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFT6</accession>
    <name>A0A0D2UFT6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="4 11">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_010G197900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <dbReference type="PubMed" id="23257886"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="209" mass="24523" checksum="EAA82859185CF1D7" modified="2015-04-29" version="1">METWKQPHPQRSRILTRNTVRDSKYNSSCKLPNTFLLSFLFCNLFLLLIKSLYSLPLILSTPPIGIRGAGVTSFWRNNIVIFIPYQIWEIRRMLGSPRLSAVNEDKEYLAKTIDKCQENSSCYQIQAGVDLMAKAKYLLQERNYQFRTDGRRILAYHSYLIEENDEGINLLKKIADMNIEDFPSNILQQIRSTWENYHQYISTIHHLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQ43</accession>
    <name>A0A0D2UQ43_GOSRA</name>
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        <recommendedName>
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        <name evidence="2" type="ORF">B456_011G090500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2UQ43"/>
    <dbReference type="STRING" id="29730.A0A0D2UQ43"/>
    <dbReference type="Gramene" id="KJB70759">
        <property type="protein sequence ID" value="KJB70759"/>
        <property type="gene ID" value="B456_011G090500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777611"/>
    <dbReference type="eggNOG" id="ENOG502QSJ8">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="KLAMCIN"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
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        <property type="project" value="InterPro"/>
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    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.30.530.20:FF:000029">
        <property type="entry name" value="START domain-containing protein 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="START-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
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    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
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    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="44"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB70759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="232" mass="26100" checksum="9E82C7692ABFB816" modified="2015-04-29" version="1">MNTSSVACSQSWSISEESLRRYVHFASESCVQELLMSASNDCGDGWKILLTLDNGVEISKRRSGSLHIFRSRCLLRSVSPQQFITVANAIDSAKQWDPDLVEARYIKDVEDNLSIIRLKFGENSKALFRKREFIVYERRESMEDGTVVVAVASLPKEIAAGLLPKPNNAIRGLLVQSGWVVEKLDDLNSCLVTYVLQLDPAGWLPKCFVNRLNTKLVMIIENLRKLVQTTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR54</accession>
    <name>A0A0D2UR54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[histone H3]-lysine(27) N-trimethyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.356</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G106100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.356" evidence="1"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2UR54"/>
    <dbReference type="STRING" id="29730.A0A0D2UR54"/>
    <dbReference type="Gramene" id="KJB71099">
        <property type="protein sequence ID" value="KJB71099"/>
        <property type="gene ID" value="B456_011G106100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777658"/>
    <dbReference type="eggNOG" id="KOG1079">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCGGALM"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031519">
        <property type="term" value="C:PcG protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050793">
        <property type="term" value="P:regulation of developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10519">
        <property type="entry name" value="SET_EZH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000001">
        <property type="entry name" value="Putative histone-lysine N-methyltransferase EZH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025778">
        <property type="entry name" value="Hist-Lys_N-MeTrfase_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058609">
        <property type="entry name" value="HTH_CLF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033467">
        <property type="entry name" value="Tesmin/TSO1-like_CXC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25996">
        <property type="entry name" value="HTH_CLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01114">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51576">
        <property type="entry name" value="SAM_MT43_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="10">
        <location>
            <begin position="654"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="770"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="893"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="480"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB71099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="919" mass="103373" checksum="DC64B58A92E95120" modified="2015-04-29" version="1">MTAKHSRSASADRSEPPKDSSMTQIEGKTLSVKEILSVIDSLKKQVAVDRSLSVKTRLEENKQKLVGITSHLYKLSKERRSSWIIDTDSASDLLTKRQKDALGMQNGIDASNGDKDGYSYQEPSTAVLMGSSIPVKNAVRPIKLTEVKKLPPYTTWIFLDRNQRMTEDQSVVGRRRIYYDQNGGEALICSDSEEELLEEDEEKKDFVESEDFILRMAIKEVGLSDPVLESLAQCLSRSPADVKARYETLMKEDTGASKNRDTEEQNWNSFLDKDLEAALDSFDNLFCRRCLVFDCRLHGCSQDLIFPADKQTPWNRTDDENAPCGLHCYRLVLKSERNDTVRSPMNPEDKSNSSSDGVAAQISSSKKSAGPSTRRKAKSSQSESASSNAKNLSESSDSEIRPRHEDSSPIPQLSPSKNKIAGKSGILKRNSKRVAERVLICMRKRQKKMEASESDSLVSGGVSPTDMRLRSNPRKENEDATSSSQKDVKSSNTGRSRRKDWPLKGVQGEIPYSETVNDLAQTSSNGCLRNEEFVDENLCKQELSDDKSWKAIEKGLFDKGLQIFGRNSCLIARNLLNGLKTCWEVFLYMTCFDNKLACHAADGVLSLLEGCSKFDLNGAMGNNEVRRRSRFLRRRGRVRRLKYTWKSAAYHSIRKRITERKDQPCRQYNPCSCQTACGKQCSCLLNGTCCEKYCGCPKSCKNRFRGCHCAKSQCRSRQCPCFAADRECDPDVCRNCWVSCGDGTGSLGVPPQRGDNYECRNMKLLLKQQQRVLLGRSDVSGWGAFLKNNVGKHEYLGEYTGELISHREADKRGKIYDRENSSFLFNLNDQFVLDAYRKGDKLKFANHSPEPNCYAKVIMVAGDHRVGIFAKERINAGEELFYDYRYEPDRAPAWARKPEASGSKKEDGAPSSGRAKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2USV9</accession>
    <name>A0A0D2USV9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G120500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2USV9"/>
    <dbReference type="Gramene" id="KJB71391">
        <property type="protein sequence ID" value="KJB71391"/>
        <property type="gene ID" value="B456_011G120500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252920" evidence="2">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB71391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="71" mass="7037" checksum="CA1C81BB2DD10B5F" modified="2015-04-29" version="1">MARQLVVLALVLIALAGVVSVAASSPGGSPPSARTGASRDGSATSSSRPSQATATSPTGDVPLDLEKYKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTM0</accession>
    <name>A0A0D2UTM0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein TIC 22-like, chloroplastic</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G151000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTM0"/>
    <dbReference type="STRING" id="29730.A0A0D2UTM0"/>
    <dbReference type="Gramene" id="KJB71969">
        <property type="protein sequence ID" value="KJB71969"/>
        <property type="gene ID" value="B456_011G151000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB71971">
        <property type="protein sequence ID" value="KJB71971"/>
        <property type="gene ID" value="B456_011G151000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777536"/>
    <dbReference type="eggNOG" id="ENOG502QV72">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MGDIQVS"/>
    <dbReference type="OrthoDB" id="196308at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.100:FF:000002">
        <property type="entry name" value="Protein TIC 22-like, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007378">
        <property type="entry name" value="Tic22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926">
        <property type="entry name" value="PROTEIN TIC 22, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33926:SF1">
        <property type="entry name" value="PROTEIN TIC 22-LIKE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04278">
        <property type="entry name" value="Tic22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="3" id="KW-0934">Plastid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB71969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32749" checksum="F5C81050BAA31E57" modified="2015-04-29" version="1">MNSPSNSKTPKIFSPFKQTPPLQDLQQAFSNIHTHCSSLFRQTHNQLMDAFNSTFSHFNPPSFSPKGPVFARIADSSKTQIALSKKNGAAMPAEKLEERLAGVPVYALSNSEEEFVLVSGASTKKSLGLLCFKKEDAEALLEQMKSMDPGMRKGGSKVVAVALNKVVQLQVAGVALRLVPESTQIKNALRERERAGFSNDSFPGVPVFQSRSLVLRSQNKSYRPVFFRKEDLEQSLLRASRDQNQLNPAFRPGDIQVAVFEDIIKGMKDTSTSNWDDVVFIPPGFDVSTDPTQLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UUG9</accession>
    <name>A0A0D2UUG9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G175700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        </source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">B456_012G0001002</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB74639.1"/>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="KJB74639.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="10" mass="1117" checksum="41354CD72699C877" modified="2015-04-29" version="1" fragment="single">RPLGFMLQVG</sequence>
</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB62390.1"/>
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        <property type="gene ID" value="B456_009G414800"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HIPP01/3/5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
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        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46413:SF1">
        <property type="entry name" value="HEAVY METAL-ASSOCIATED ISOPRENYLATED PLANT PROTEIN 6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HMA_2"/>
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    </dbReference>
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        <location>
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            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="2">
        <location>
            <begin position="125"/>
            <end position="196"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <begin position="224"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB62390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="357" mass="38550" checksum="0ABFDBBCB9A8A5E6" modified="2015-04-29" version="1">MGEQKEGAKPEAEKKPAADSGAKKDDGKVTVVYKIDMHCEGCAKKIKRSIKHYEGVEDVKADCGANKLTVIGKVDPAKIRDRLAEKTKKKVDLISPQPKKDAAPAGGDKKPDAEKKPEQKKPPKESTVVLKIRTHCDGCIHKIRKIILKVNGVQSVDVDGAKDLVTVKGTMDVENLVPYLREKLRRNVEVVPPKKEDAGEKKDGGEKNDAGGDKKEKGKEAAAAGGGGKKGGGGGEKEGGEKKEGGGGEKKEGGGEKKEGGEKKEGGGEAKMEVSKMEYHGYAYPPQPMYLSGGQEYGGPSYAIEGYQNHQRYGYVDEGYMHPHPVYVNQGYMIDPRHPLHAPQMFSDENPNACSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V287</accession>
    <name>A0A0D2V287_GOSRA</name>
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        <recommendedName>
            <fullName evidence="5">Pyrrolo-quinoline quinone repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G056900</name>
    </gene>
    <organism evidence="6 7">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <cofactor evidence="1">
            <name>pyrroloquinoline quinone</name>
            <dbReference type="ChEBI" id="CHEBI:58442"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial PQQ dehydrogenase family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB75771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V287"/>
    <dbReference type="STRING" id="29730.A0A0D2V287"/>
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        <property type="protein sequence ID" value="KJB75771"/>
        <property type="gene ID" value="B456_012G056900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUFM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.10">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_b-propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303:SF10">
        <property type="entry name" value="OUTER MEMBRANE PROTEIN ASSEMBLY FACTOR BAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32303">
        <property type="entry name" value="QUINOPROTEIN ALCOHOL DEHYDROGENASE (CYTOCHROME C)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269013" description="Pyrrolo-quinoline quinone repeat domain-containing protein" evidence="4">
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            <begin position="19"/>
            <end position="330"/>
        </location>
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        <location>
            <begin position="57"/>
            <end position="298"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB75771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="36767" checksum="C677D32152F22CDB" modified="2015-04-29" version="1">MELVLSLCLLSLPASTTGKNNDVQDWLNHGGNMLNRRFADKETMISPETASRLRLKWKFNAGQDISPTHAIFDGTVYFPSWDGYIYAVKASNGGLVWKKKLQQLTGLNSTKAVSNIDPNITVSRTTPVIAYDLLIFGMSGPAYVVAVKRSNGELVWLTQLDKHPKAIITMSGTYYNGSVFFCYISSSYAPQLAKGSFVKLNARTGKILWRTYMLPNNLGQRGEYTGVAIWGSSLSIDIRRNHVYIGTGNLYSAPKNVRNCQERKNNRTDMPSTDECVEPENHSVSILALDLDTGKVKWFNQLGGYDVWFFACNNVPNPKCPPSPKLDADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3A6</accession>
    <name>A0A0D2V3A6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="3">Small acidic protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G072500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V3A6"/>
    <dbReference type="Gramene" id="KJB76114">
        <property type="protein sequence ID" value="KJB76114"/>
        <property type="gene ID" value="B456_012G072500"/>
    </dbReference>
    <dbReference type="OMA" id="PMLMEFV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB76114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="60" mass="6773" checksum="97182EE589FBAA30" modified="2015-04-29" version="1">MRPMLMEFVTDPDDQGSAMEVDDVDTPEIFGEGVIASDNKLAYADFFNNFEDDFDDSDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V7D3</accession>
    <name>A0A0D2V7D3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G168900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V7D3"/>
    <dbReference type="Gramene" id="KJB77939">
        <property type="protein sequence ID" value="KJB77939"/>
        <property type="gene ID" value="B456_012G168900"/>
    </dbReference>
    <dbReference type="OMA" id="GEACPEI"/>
    <dbReference type="OrthoDB" id="940717at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01019">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50863">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="7"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB77939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="242" mass="27094" checksum="0104F723E066F53F" modified="2015-04-29" version="1">MAAHSGIIFFKELTDTDVKKRLVVPKEYQDFFLPSYGRLPAKIKLMYDGKIWEVKCTVRKKGYLKPVLSVGWKKFVVANELKVGDRITMYKDEDGFSHYMVEVEKPPASNQHDTLPDSPALSFIHHKPDETTLKYRKEVPEDLAGAHHQPDIAPMNIPVNAWQRPSIGMFGTNVSNERADHFSLMTYGSGTSAAGGIGEACPEIITDHHQDLSLDLVRRQPGTIPPPYVGEVKLDLTLAPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V9W7</accession>
    <name>A0A0D2V9W7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">cAMP-regulated phosphoprotein 19-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G062200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V9W7"/>
    <dbReference type="STRING" id="29730.A0A0D2V9W7"/>
    <dbReference type="Gramene" id="KJB79691">
        <property type="protein sequence ID" value="KJB79691"/>
        <property type="gene ID" value="B456_013G062200"/>
    </dbReference>
    <dbReference type="OMA" id="CASTEIN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF28">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 19-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB79691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="11985" checksum="90BFA1FE79924158" modified="2015-04-29" version="1">MEGAKEQIVQESKNSTLPSQDEEAAIKKKYGGIIPKKPPLISKDHERAYFDSADWALGKQQGVEKPKGPLEALRPKLQPTQQQTRYRKSPCAPADGAVGGSAQPEGGTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VJ97</accession>
    <name>A0A0D2VJ97_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G233700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VJ97"/>
    <dbReference type="STRING" id="29730.A0A0D2VJ97"/>
    <dbReference type="Gramene" id="KJB83179">
        <property type="protein sequence ID" value="KJB83179"/>
        <property type="gene ID" value="B456_013G233700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783388"/>
    <dbReference type="eggNOG" id="KOG4791">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMSASEC"/>
    <dbReference type="OrthoDB" id="5395350at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000021">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041686">
        <property type="entry name" value="Znf-CCCH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 32-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15725">
        <property type="entry name" value="ZN-FINGER, C-X8-C-X5-C-X3-H TYPE-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15663">
        <property type="entry name" value="zf-CCCH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="409"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="483"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB83179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="531" mass="60794" checksum="1C757D1F8B989429" modified="2015-04-29" version="1">MEEQLLKRNTDCVYFLASPFTCKKGLDCEYRHSEVARLNPRDCWYWLAGNCINPTCGFRHPPLDVHSQVPSESAALPYQCSTAANKTNLPCYFYFNGFCNKGDRCSFLHGPHESTITVNSLKTGALPLDHKTFVENDVGAVQTETHPNPSKTAPNSIKDTGVQLKTDLEEPVPKTMIKRSVSPKTSVFELEQAGFVSSQSLLLKEGITQTGSPICTDESLEEQLDDPFEPEEPEERWESSEGFDVLVDNKSEDLDYGNDSEYQKDPEEEQTDYFFSYDYEDSVQHETRYPDLEFSYDRDVYDAYEGSDNEYIFNNPRNPFAHPGDKRRLDSMFSQKRRRLLPIKRSIDVDLRDYLSKRRVVKGNPLKCLSRSEYSHLISRSLERPRRRSMGRKLSGRLASKVGKHYIESTGGQGGFGNGTNRRGWLKHLEPNRSIRRPYREKRLPKRKSVSSEVSRNLISRERKYEDASTAFTGPKTLAQIREEKRKTEENGGKMRHSIVTASADFQGPKPLSEILKDKERLAKKGTNFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKG5</accession>
    <name>A0A0D2VKG5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="10">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_N027600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="10"/>
    <dbReference type="EMBL" id="KB204910">
        <property type="protein sequence ID" value="KJB84461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VKG5"/>
    <dbReference type="STRING" id="29730.A0A0D2VKG5"/>
    <dbReference type="Gramene" id="KJB84461">
        <property type="protein sequence ID" value="KJB84461"/>
        <property type="gene ID" value="B456_N027600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRQWGFF"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254285" description="3-dehydrosphinganine reductase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB84461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="318" mass="34882" checksum="AB79C09802942E5A" modified="2015-04-29" version="1">MVLFGLLLLPILLLLLYFIVRPRPINIPIKNRHVFITGGSMGIGLAIAKQAASEGARISLLARSVDRLQKAKESICQAYEVEVSIFSADVRDYDAVERAIKEAGPIDVLVVNHGVYYLEEFETQGLDVMKTMIDVNLMGSFNVIKAALPLMKDRKDKGPASIALMSSMAGQAGIYGFAAYSATKFGLRGLAEALQQELLVNNIHLSIIFPPVTETSARERMPEITKIILESSPGMKAEEVGKITIQGIKSGSFSIPCRLDGRAVAIATAGLSPQTSFLMASIEVVFAGLFRFVALLLQWRGYEIIEKYNYSHKKQQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VPU9</accession>
    <name>A0A0D2VPU9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G208800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VPU9"/>
    <dbReference type="STRING" id="29730.A0A0D2VPU9"/>
    <dbReference type="Gramene" id="KJB73005">
        <property type="protein sequence ID" value="KJB73005"/>
        <property type="gene ID" value="B456_011G208800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SXH1">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06222">
        <property type="entry name" value="RNase_H_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044730">
        <property type="entry name" value="RNase_H-like_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052929">
        <property type="entry name" value="RNase_H-like_EbsB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074">
        <property type="entry name" value="BNAC02G40300D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47074:SF61">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="111" mass="12566" checksum="2DB19BFC83E7991E" modified="2015-04-29" version="1">MGSGFQRHNLVHSVVIAEALAVLHELQFALDMGFSKVILESDSRLVVNNIQKSSEDYSESRPFTWDAKNLARKFQCCRFQFITREENGAAHALAVEGMRAEGIHSGWKMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1Q9</accession>
    <name>A0A0D2W1Q9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G012000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46288:SF70">
        <property type="entry name" value="CYSTEINE_HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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            <begin position="9"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_013G168600"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033396">
        <property type="term" value="P:beta-alanine biosynthetic process via 3-ureidopropionate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
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    </dbReference>
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        <property type="entry name" value="CN_HYDROLASE"/>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11596" checksum="9F82F15DC185D725" modified="2015-04-29" version="1">MLQEAWMMPFAFCTREKRWCEFAEPVNGESTQFLQEFALKYNMVIISSILERDINHGETLWNTVVIIGNHGNIIASLEYCYFLFKLGTSMEPVAFVDCNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W9E3</accession>
    <name>A0A0D2W9E3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_013G253100</name>
    </gene>
    <organism evidence="21 22">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
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            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W9E3"/>
    <dbReference type="SMR" id="A0A0D2W9E3"/>
    <dbReference type="STRING" id="29730.A0A0D2W9E3"/>
    <dbReference type="Gramene" id="KJB83565">
        <property type="protein sequence ID" value="KJB83565"/>
        <property type="gene ID" value="B456_013G253100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784546"/>
    <dbReference type="eggNOG" id="KOG0032">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFYIITE"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000015">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000056">
        <property type="entry name" value="calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000004">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0519">Myristate</keyword>
    <keyword evidence="9 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="73"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="446"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="20">
        <location>
            <begin position="485"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="16"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB83565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="527" mass="58792" checksum="3AF47F950DEB6057" modified="2015-04-29" version="1">MGNCCTRGDGSDKLEKAAAGYGNGDADPTVTSHQTSYRTAPSSQGASTVGKQSKPAPMGPVLGRPMEDVKATYTIGKELGRGQFGITHLCTHKTTGEQFACKTIAKRKLSSKEDVEDVRREVQIMHHLTGQPNIVELKGAYEDKHAVHLVMELCGGGELFDRIIAKGHYTERAAASLLRTIMQIVHTFHSMGVIHRDLKPENFLLLGKEENSPLKVTDFGLSVFFKPDEIFKDIVGSAYYIAPEVLKRKYGPEADIWSVGVMLYILLSGVPPFWAESENGIFNAIIKSHVDFSGKPWPSISHQAKDLVKRMLNPDPKRRLTAAQVLSHPWIKEDGEAPDTPLDNAVLSRLKQFKAMNQFKKVALKVIAGCLSEEEIRGLKEMFKAMDTDNSGTITLEELRQGLAKQGTKLSEYEVKQLMEAADADGNGTIDYDEFITATMHMNRMDREEHLYHAFQHFDKDNSGYITTEELEQALREYGINDSTDIKQILSEVDADNDGRINYDEFVAMMKKGNPEPNPKKRRDVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LXH4</accession>
    <name>A0A0D2LXH4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G115200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LXH4"/>
    <dbReference type="Gramene" id="KJB08947">
        <property type="protein sequence ID" value="KJB08947"/>
        <property type="gene ID" value="B456_001G115200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791844"/>
    <dbReference type="eggNOG" id="ENOG502QRHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KANCRNT"/>
    <dbReference type="OrthoDB" id="9514740at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31681:SF4">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="383" mass="42550" checksum="CDB7D9D8A0ECE5AB" modified="2015-04-29" version="1">MAKPNFGSFFNKFLSLFILLLHLGCFIFTAKDHQKPPKKRKHSPLSPSSPSHKPHANKSLSSTWSYLKRIFTSSKANCRNTIPTHPRAALTPALTSARNSQQSLVSMVIPPETHLSETSLPPPHPESDISSDNPFSPLRNDIFPCTACGEVFQKPHFLEQHQATKHAVSQLLDGDSGKNIVRIIFKTGWTDKVRNPEIHRILKIHNSPKILARFEEYRELVKAKAARNGAVVGRRDERCIADGNELLRFYCSTFMCDLGLNGSSGICSQQYCSVCGIIKSGFSPKMDGISTLSTSWRAHMAVPEDVEEEFKFMNVKRAMLVCRVVAGRVGSEGDETNKEDGGFDSVIGRGGGNMAHHTKVDEEELLVFNPRAVLPCFVIVYTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M312</accession>
    <name>A0A0D2M312_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G254300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M312"/>
    <dbReference type="STRING" id="29730.A0A0D2M312"/>
    <dbReference type="Gramene" id="KJB11352">
        <property type="protein sequence ID" value="KJB11352"/>
        <property type="gene ID" value="B456_001G254300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767826"/>
    <dbReference type="eggNOG" id="ENOG502QWSH">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPRMECG"/>
    <dbReference type="OrthoDB" id="730183at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744:SF4">
        <property type="entry name" value="NAC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31744">
        <property type="entry name" value="PROTEIN CUP-SHAPED COTYLEDON 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB11352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="294" mass="34068" checksum="4BF2F292C0F86C6D" modified="2015-04-29" version="1">MGLRDIGATLPPGFRFYPSDEELVCHYLYKKIANEEVLKGTLVEIDLHTCEPWQLPEVAKLNANEWYFFSFRDRKYATGFRTNRATTSGYWKATGKDRTVVDPRTQQVVGMRKTLVFYRNRAPNGIKTGWIMHEFRLETPHMPPKEDWVLCRVFHKSKGAENSTRLSSPMMLEPSIHAPSLADHTTMACGYHHQINSLATKPAHQSHSQSLLNLLQYNSHQENDDDDKNNNNLHCSNNEVSSKVDDDYEFLWDMNMEENSLGDDHHHHHRHLIHGVASNSDDMRFEIDNSMIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MBB0</accession>
    <name>A0A0D2MBB0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_002G151900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MBB0"/>
    <dbReference type="STRING" id="29730.A0A0D2MBB0"/>
    <dbReference type="Gramene" id="KJB14947">
        <property type="protein sequence ID" value="KJB14947"/>
        <property type="gene ID" value="B456_002G151900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1687">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WYWIRIG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="5">
        <location>
            <begin position="10"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="136" mass="15159" checksum="4A459870A93AC958" modified="2015-04-29" version="1" fragment="single">LWPLIYGTSCCFIEFASLIGSRFNFDRYGLVPRSSPRQADLILTVGTVTMKIAPSLVRLYEQMPEPKYVIAMGTCKITRGMFSTDSYSTVQGVDKLISMDVYLLGYPSKPEAIIDAITKGQATRLSSKARPKFGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MZ11</accession>
    <name>A0A0D2MZ11_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_004G159000</name>
        <name evidence="15" type="ORF">Gorai_014885</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
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        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
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        <property type="entry name" value="Cyt_P450_sf"/>
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    <dbReference type="PANTHER" id="PTHR24296">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
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    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
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    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
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    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
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        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU000461"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB24757.1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0584052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="60014" checksum="BC0BACE9ECD7CD4A" modified="2015-04-29" version="1">MDISTALLLLAAITAYLLWFTFISRSLRGPRVWPLLGSLPGLIKNCDRLHDWISDNLRACGGTYQTCICAIPFLAQKQGLVTVTCDPRNLEHILKTRFDNYPKGPTWQSVFHDLLGQGIFNSDGDTWLFQRRTAALEFTTRTLRQAMARWVTRAIKFRFCPILEEAQAKSEPVDLQDVLLRLTFDNICGLAFGKDPETCAQRLPENGFASAFDRATEASLQRFILPEVLWKLKKWLRLGLEASLSRSLVHMNEYLSDVIVTRKQELLSQQKDGNPHDDLLSRFMRKKESYSEEFLQHVALNFILAGRDTSSVALCWFFWLLTQHSTIEDKILHEICTVLIETRGIDTSTWFDEPLGFEEVDRLIYMKAALSETLRLYPSVPEDSKHVVVDDVFPDGTFVPAGSSVTYSIYSVGRMRSIWGDDCLEFRPERWLTADGKEFIMHDSYKFVAFNAGPRICLGRGLAYLQMKSVAAAALLRHKLTVAPGHKVEQKISLTLFMKYGLKVNVHGRDLGAIVEKIINEQKLHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NBS5</accession>
    <name>A0A0D2NBS5_GOSRA</name>
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    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G130000</name>
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    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_005G130000"/>
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        <property type="component" value="Chromosome 5"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
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    <proteinExistence type="predicted"/>
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        <location>
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            <end position="152"/>
        </location>
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        <location>
            <begin position="189"/>
            <end position="209"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="300"/>
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            <end position="283"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB30007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="413" mass="46655" checksum="017DB21228CDFB29" modified="2015-04-29" version="1">MAGVSLKCGDCGALLKSVEEAQEHAELTSHSNFSESTEAVLNLVCSSCGKPCRSKIESDLHTKRTGHTEFIDKTLEAAKPISLEVPKVAKESEEAIAAGSTSEPEEMVVPEVDKKLLEELEAMGFPTARATRAIHFSGNTSLEAAVNWVVEHEADPDIDQMPMVPVNRHVEASKPSLTPEEMKLKAQELRERARKKKEEEERRMEREREKVRIRVGKELLEAKRIEEENERKRLVALRKAEKEEEKRAREKIRQKLEEDKAERRRKLGLPPEEPSAAPKPSAPIVEEKKSALPVRPATKAEQMRECLRSLKQNHKDDDAKVKRAFQTLLTYIGNVARNPDEEKFRKIRLNNQTFQDRVGSVKGGVEFLELCGFEKVEGEEFLFLSRNKVDMQVLNSAGSELNSAINNPFFGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGT4</accession>
    <name>A0A0D2NGT4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_005G218200</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGT4"/>
    <dbReference type="SMR" id="A0A0D2NGT4"/>
    <dbReference type="STRING" id="29730.A0A0D2NGT4"/>
    <dbReference type="Gramene" id="KJB32002">
        <property type="protein sequence ID" value="KJB32002"/>
        <property type="gene ID" value="B456_005G218200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795051"/>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRQDFNN"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000024">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000016">
        <property type="entry name" value="Somatic embryogenesis receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="16 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10 24" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 23" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="24">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002259671" description="non-specific serine/threonine protein kinase" evidence="24">
        <location>
            <begin position="29"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="25">
        <location>
            <begin position="291"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="22">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB32002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="620" mass="68643" checksum="F7F581EAEA586BDA" modified="2015-04-29" version="1">MKENMTRRLISFCLWLIFVLDLAFRVAGNAEGDALNALKTNMADPNNVLQSWDPTLVNPCTWFHVTCNSENSVTRVDLGNANLTGQLVPQLGSLPNLQYLELYSNNISGMIPDELGNLTELVSLDLYLNKLTGDIPTTLGQLKKLRFLRLNNNSLVGTIPLSLTTIDTLQVLDLSNNGLVGDVPVNGSFSLFTPISFANNKLNNPPPAPPPPIPPTPPAQSGISSTGAIAGGVAAGAALLFAAPAIVLALWRKRKAPDHFFDVPAEEDPEVHLGQLKRFSLRELQVATDNFSNKNILGRGGFGKVYKGRLADGSLVAVKRLKEERTQGGELQFQTEVEMISMAVHRNLLRLRGFCMTPTERLLVYPFMVNGSVASCLRERSEFQPALDWAIRKRIALGAARGLAYLHDHCDPKIIHRDVKAANILLDEEFEAVVGDFGLAKLMDYKDTHVTTAVRGTIGHIAPEYLSTGKSSEKTDVFGYGVMLLELITGQRAFDLARLANDDDVMLLDWVKGLLKERKLETLVDSDLNGNYIDEEVEQLIQVALLCTQGTPMERPKMSEVVRMLEGDGLAERWEEWQKEEMVRQEFNQAHHYNHHQPNANWIIADSTSHIPPDELSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKL6</accession>
    <name>A0A0D2NKL6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_006G020900</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKL6"/>
    <dbReference type="STRING" id="29730.A0A0D2NKL6"/>
    <dbReference type="Gramene" id="KJB33602">
        <property type="protein sequence ID" value="KJB33602"/>
        <property type="gene ID" value="B456_006G020900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RMXX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030247">
        <property type="term" value="F:polysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000084">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000043">
        <property type="entry name" value="Wall-associated receptor kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045274">
        <property type="entry name" value="WAK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025287">
        <property type="entry name" value="WAK_GUB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27005:SF432">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13947">
        <property type="entry name" value="GUB_WAK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247794" description="Protein kinase domain-containing protein" evidence="16">
        <location>
            <begin position="28"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="406"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="734" mass="82085" checksum="138A90A48CE4CE8D" modified="2015-04-29" version="1">MGFHLALYFILLLLFLFLFLLCPILQAAEFEEPACGQEVCGNITISSPFGIHSSCYTIPWFRVTCKATRDGQKPFINVNGIDLEVLDFTSADAILISNPVAYINCDHTSEASVSVNLSGTPFFFSSERNNFGSVGCGNLAAILSDEADSLGGCVQPRCDDGASKSGCFTEMTANLTSYTVSMKAMYPDSNRCASAFIYSRDFFRSGYPLPTGINIGTTHAPSVLNWNSTYCGDAGTVMVNHPITYFNCRKNHYNGMSLNLIGTRFYYSDSGNIFWSSGCDENCGYYQNCRMLCFNTPSNYCSSESCPPSYEYDSTRFRCERKTKAQKTSNSSLESIIVGCSTSIGTLFLILATWSMYKVLKRKQNIILKKKYFKKLLQQHLPSNEGNVEKLTLFTSKEMEKATDHYNKNRILGQGGQGTVYKGMLIDGSIVAIKKSKMVEGKKFDEKKVEQFINEVIILSQINHRNVVKLLGRCLEAEVPLLVYEFIPNGTLYDLIHNQNEGLPLTWEMRLGIAIEIANALFYLHSAASAPIYHRDIKSSNILLDEKYRAKVSDFGTSRSVALEQTHLTTRVQGTFGYMDPEYFRSSQFTEKSDVYSFGVVLTELLTGQKPISVQQSESVRSLVSYFLHSMQENSLFNILDPMVVKDGSEKEIIVVALLAKRCLHFNGKKRPTMKQVAMELELIKASGGNVIEDRGDEESEIDDMIHLWETNPSSSMSRTITTDSVTFPLNSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NKV5</accession>
    <name>A0A0D2NKV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_006G028100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NKV5"/>
    <dbReference type="Gramene" id="KJB33732">
        <property type="protein sequence ID" value="KJB33732"/>
        <property type="gene ID" value="B456_006G028100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB33733">
        <property type="protein sequence ID" value="KJB33733"/>
        <property type="gene ID" value="B456_006G028100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798293"/>
    <dbReference type="eggNOG" id="KOG4374">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="76949at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF74">
        <property type="entry name" value="OS08G0526500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="211"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="284" mass="32298" checksum="5166A5D4708A6C65" modified="2015-04-29" version="1">MAKLRVTITGDGSSKVVKMGDDAMGGHRRMNGNKRFLQDKPWRNVGNRRHQINGVQWRSNGFKGQGSRIAGKDLRFKLMRKRGPFQFRDTFEDHRRNMEKPSNHIQPPQNRNKHMSETGPNRINNLNQVSHNSITEVLQIYSLQTIDGSRGFPEMPKIIPTSLPRNELFPSNGIFNPSRESGLMPGRGKAITSMPITHAAPMSSIMQRKPRVDEEPFTVVTLLNSLGLGKYAIHFTAEEVDITALRQMGDRDLKELGIPMGPRKKLLLALRPHSRRHLPHIIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NTT5</accession>
    <name>A0A0D2NTT5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G165100</name>
        <name evidence="5" type="ORF">Gorai_001146</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NTT5"/>
    <dbReference type="Gramene" id="KJB36557">
        <property type="protein sequence ID" value="KJB36557"/>
        <property type="gene ID" value="B456_006G165100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799767"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MIYDVME"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050872">
        <property type="entry name" value="PPR_P_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128">
        <property type="entry name" value="MITOCHONDRIAL GROUP I INTRON SPLICING FACTOR CCM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46128:SF335">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="249"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="284"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="319"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="389"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="424"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="459"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="494"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="529"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB36557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0588030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="70225" checksum="FB8F12D6820268BA" modified="2015-04-29" version="1">MSTKNLVKIFEKSLPRYPSSPANKKTAEEIAEILIKSGLKPFKTNPSLISDLDSNTTDLVLSNPNLPIRSCILFFNFLRTNLSLTPQKPNLETHLSFIRRLHKAGNFEEIKQVLKFILSDDNLRYPVEEILSLFDFEFDNSYFLNKLSDLLFRVCVDNKRFEEANLVFDYMKKMGFNIDERSCILYLVALKKSDKGDSFFVFFRRMVKSGVEIGAYSMTIVIDGLCRRGEVEKGRELMNEMASKGVKANVVTYNTILNAYVKRKDFGVVSEVLMLMEREEVEYNAATYTVLIEHFGNIGKHDEVEKLFDEMRERKVEMDVHLYTSMIHWHCRRGSIKKAVSLFDELTEKGLVPNARVYGALIDGLCKTGQMEAAQLLLKDMQSQKIVVNQVIINTLLHGYCRKGMMDDALRLVAVMEKKGFKPDVFTYNIMASGMCRLKRYEEAKRWLFMMVENQLTPNAINFTTLIDIHCKEGNIVEAKRLFRQLQGKGESPNTVTYNALIDGYSKKGEMKDAYKLRDEMEAKGRIPDVYTYTSLVHGECSFGNIDEAMKLFNEMRQKGLVPNVVTYTAIISGLSKKGRSDEAFRLYKEMIGLGHVPDQRVYSSLVGSLHTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NV14</accession>
    <name>A0A0D2NV14_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">E3 ubiquitin-protein ligase RMA</fullName>
            <ecNumber evidence="11">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Protein RING membrane-anchor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase RMA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G017800</name>
        <name evidence="15" type="ORF">Gorai_023905</name>
    </gene>
    <organism evidence="14 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="15 17" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">8</strain>
            <tissue evidence="15">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">E3 ubiquitin-protein ligase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The RING-type zinc finger domain is responsible for E3 ligase activity.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="11"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0581732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NV14"/>
    <dbReference type="STRING" id="29730.A0A0D2NV14"/>
    <dbReference type="Gramene" id="KJB17828">
        <property type="protein sequence ID" value="KJB17828"/>
        <property type="gene ID" value="B456_003G017800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787566"/>
    <dbReference type="eggNOG" id="KOG0823">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRTHRFP"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16745">
        <property type="entry name" value="RING-HC_AtRMA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU369090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB17828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="MBA0581732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="228" mass="24848" checksum="1A4067B9D6A9C09A" modified="2015-04-29" version="1">MASGFGESTSRPPPSPPCSGSTDNANDAGGFECNICFELAQDPIVTLCGHLFCWPCLYRWLHHHCHCHECPVCKALIQEEKLVPLYGRGKNHTDPRSKLYPGMEIPNRPTGQRPATAPPPPPEANPFGNYGFGLMGGFVPMATTRIGNFTMGFGGLLPSLFNIQSHGFPDATVYGTTSGFPFGYNTVHGGHPHWFPQPPTTRGQQADNVLKNLLLLIGVFVVLALLYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NVQ2</accession>
    <name>A0A0D2NVQ2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G032400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NVQ2"/>
    <dbReference type="Gramene" id="KJB18063">
        <property type="protein sequence ID" value="KJB18063"/>
        <property type="gene ID" value="B456_003G032400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787698"/>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GKITHLM"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000129">
        <property type="entry name" value="Leucine-rich repeat receptor-like kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000734">
        <property type="entry name" value="Receptor-like protein 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27004:SF136">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248941" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="13">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB18063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="28646" checksum="572D2A128A6D3693" modified="2015-04-29" version="1">MGFVILLLLTFTTLPLSSSDPNDEACLTQLSQTLKDPLNNLQNWTKSTFANPCSGFTSYLPGATCNNGRIYKLSLTNLSLQGSISPFLSNCTNLQSLDLSSNSISGPIPQDLQYLVNLAVLNLSSNRLEGEIPQQLALCAYLNVIDLHDNLLTGQIPQELGLLARLSAFDVSNNKLSGPIPASLGNRSGNLPRFNATSFGGNKDLYGYPLPPMKSKGLSVLAIVGIGLGSGLASLVISFTGVCIWLKITEEKMAAAEEGKIGQFMPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P3X5</accession>
    <name>A0A0D2P3X5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G063300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P3X5"/>
    <dbReference type="Gramene" id="KJB40437">
        <property type="protein sequence ID" value="KJB40437"/>
        <property type="gene ID" value="B456_007G063300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802306"/>
    <dbReference type="eggNOG" id="ENOG502QR4Y">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NSTHDHI"/>
    <dbReference type="OrthoDB" id="1728340at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="15"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="192"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB40437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="375" mass="41031" checksum="1C8B3FB9958695C5" modified="2015-04-29" version="1">MGKNLCEIVERMKVVIVLLVVQAALAGVIVFYKLALVEGMSMRVLIAYRFIFATACITPLAFIFERESKANLTWKVVFQGVLSGFFGGALGPNLFIASLSLTFSTYATAMSNLVPIATFILAAILRLERLGMKTLAGQAKLWGTLLSIGGAMILTFYKGKELNLWSTNINVVKHGGHHHTSTKHAAVGDQVLGSLLALASCLAFAIWYIIHAKMGENYPFTYSASALFCITASIEATIYTIITDRNWSDWKLGWNLRLLSVVYTGAVGSGLTVVLMSWCLRLRGPLFVSIFNPLTLVYVAIVGSLIFDEKLSIGRIIGSVIIIIGVYVVLWGKAKEKKTWEQLAAQPERPSEPQTVDVVIQDADHCCDPSKQISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P789</accession>
    <name>A0A0D2P789_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_007G112100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P789"/>
    <dbReference type="STRING" id="29730.A0A0D2P789"/>
    <dbReference type="Gramene" id="KJB41607">
        <property type="protein sequence ID" value="KJB41607"/>
        <property type="gene ID" value="B456_007G112100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802838"/>
    <dbReference type="eggNOG" id="KOG0583">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12195">
        <property type="entry name" value="CIPK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14663">
        <property type="entry name" value="STKc_SnRK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000279">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000096">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.80:FF:000002">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018451">
        <property type="entry name" value="NAF/FISL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004041">
        <property type="entry name" value="NAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF145">
        <property type="entry name" value="CBL-INTERACTING SERINE_THREONINE-PROTEIN KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03822">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50816">
        <property type="entry name" value="NAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="NAF" evidence="15">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB41607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="449" mass="50967" checksum="7DFAC6C7E94782FF" modified="2015-04-29" version="1">MSSKRKVLQGNTTRTRVGKYELGKTLGEGSFAKVKFAKNVETGECVAIKILDRDQVLRHRMVEQFCMGQIKREISTMKLIKHPNVIKIFEVMASKTRIYIVIEFVDGGELFDKIAKNGRLKEDEARSYFHQLINAVDYCHSRGVYHRDLKPENLLLDSYGVLKISDFGLSAFSQQVREDGLLHTACGTPNYVAPEVLRDKGYDGTSSDIWSCGVILFVLMAGYLPFDEPSLVGLYKKIWEASFSCPSWFSSGARNLIKRILDPNPVTRITIPEILQDEWFKKGYKPPKFEQDEDVNLDDIDAVFNDSTEHLVTERKEKPVSMNAFELISRSQSFSLDKLFEKQCGSVKPETSFASQRPPNEILSKIEEAAKPLGFNVHKRNYKMKLKGDKSGRKGQLSVATEVFEVAPSLHMVELRKTGGDTLEFHKFYKSFSSELKDIVWKSGETAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P9E6</accession>
    <name>A0A0D2P9E6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G097800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P9E6"/>
    <dbReference type="STRING" id="29730.A0A0D2P9E6"/>
    <dbReference type="Gramene" id="KJB23428">
        <property type="protein sequence ID" value="KJB23428"/>
        <property type="gene ID" value="B456_004G097800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015630">
        <property type="term" value="C:microtubule cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF23">
        <property type="entry name" value="KINESIN MOTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 2" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="4">
        <location>
            <begin position="88"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB23428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="901" mass="100683" checksum="63F053C7FDA113FD" modified="2015-04-29" version="1">MSSKKSIQNLGETIHSLLGFKSHLTSTWVKSVCEIVKKLPSGNEKDDESAAKEISKIKEEMAALTHCINQSNIQRGQLLHDLLDLKGNIRVFCRVRPFTLEESIGGGIGGIGAVVALDTSNLLLKLGDNKTKRYTFDNVFQGSSQDGIFSKVEPVIKSVLDGYNASIFAYGQTGTGKTFTMEGTLDSPGIVPRTIETLFKQALDSNHTFLITFSMLEIYLGNLKDLLVPQATRATDPLPPCLSIQTDPKGGIGIENLVSIQVSDFNQALKLYRLGCQLRSTASTNSNTTSSRSHCMIRISMTCFDAPERRRETNKIWLVDLGGSERVVKTKAWGRRLDEGKAINLSLSALGDVIHALQRKKSHIPYRNSKLTQVLKDSLGEDSKTLMLVHVSPKEEDLCETICSLNFAARVKSVQLGHEESNEVRNQREAAMKNLHQTIKKIEDERRYIRGKIQILNHKLEELTRRGLPLEQQAEACDLSTELGPPSELDFTKNRTGNVRSQLPRFMRSTISSRTKTGMEHQTSLHSRRRRRPSSQRAGSVSFPVKNHSECNSDRSISRSTCAVELNRKTSMELDNVTVYSQDTSECDTKMVVTNRKSNKCKSTKVLKVDQWLTLHKDEGSISGSVPRNKWVSDIPLPEKKHRSNRVKKTHILCNDKVFKKQKKASSVVAVSQRVEDKPPTLKDLFAEESNSSFICPPQPTMCLSTGHQQDSLDGSLIEYGQGGSLSPPDSCCDGSVHFIDNEDEFYGTPMVEVVEDTEHRPNSSMMKISSYLLSPDDSISNSQEIFGVSAQALEPEQYHKQVMATEVNGKEDMDASSQSSPQEMRLNLCRPKSQRRLFIDDLKQKDPRMMTLIKSQEISKNQGACCLVKQKVEKSWAIALLGLGFLDLGFNHDFFYGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PHZ3</accession>
    <name>A0A0D2PHZ3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_007G318900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16301"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57967"/>
            <dbReference type="EC" id="3.2.2.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16302"/>
        </physiologicalReaction>
    </comment>
    <dbReference type="EC" id="3.2.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PHZ3"/>
    <dbReference type="Gramene" id="KJB45662">
        <property type="protein sequence ID" value="KJB45662"/>
        <property type="gene ID" value="B456_007G318900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SI7S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IENIQAF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061809">
        <property type="term" value="F:NAD+ nucleosidase activity, cyclic ADP-ribose generating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10140:FF:000007">
        <property type="entry name" value="Disease resistance protein (TIR-NBS-LRR class)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000386">
        <property type="entry name" value="Disease resistance protein RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.430">
        <property type="entry name" value="Helical domain of apoptotic protease-activating factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="entry name" value="Toll/interleukin-1 receptor homology (TIR) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042197">
        <property type="entry name" value="Apaf_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045344">
        <property type="entry name" value="C-JID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044974">
        <property type="entry name" value="Disease_R_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011713">
        <property type="entry name" value="Leu-rich_rpt_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058546">
        <property type="entry name" value="RPS4B/Roq1-like_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058192">
        <property type="entry name" value="WHD_ROQ1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017:SF570">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN (TIR-NBS CLASS)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11017">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20160">
        <property type="entry name" value="C-JID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23286">
        <property type="entry name" value="LRR_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07725">
        <property type="entry name" value="LRR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01582">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23282">
        <property type="entry name" value="WHD_ROQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00255">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="Toll/Interleukin receptor TIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0611">Plant defense</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TIR" evidence="8">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB45662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1257" mass="142857" checksum="9A774547A718CA3D" modified="2015-04-29" version="1">MLASGSSSSSSSATAADMIQARTYDVFLSFRGQDTRDGFVSHLYKHLSRKNIETFIDSEKLRRGDEISEALLTAIQGSRVSVIVFSKDYASSKWCLAELVKIMDCNKWVVPVFYSVDPGDVRNQTGSFAEAFAKHEENFKHEPEKVKSWRSALTAAGKLAGWDSQVTRPESRLIDEIVNDILKKLNRGTSNAYLKGLVGIERRMEQVISLIQVGFPDVRRLGIWGMGGTGKTTLAEAVFHHISNGFQSCYFLANVRESEEHGRLFQLRQEFLSTIMEDGNLNISTPTIGAGFLKDRLSRKMVLIVCDDVSNLSQFEFLFKGINQLCPGSRVIVTTRNKQVLIQNDIDRIYEMEKLDEGESLQLFCQRAFKSNYPTRYRLELSKMVLSVADGNPLAIKVFGSSLYGKEKTYQESTVKKLKQVPNPDIHKLLICSFDALDCEEKDIFLDIACFFKGENRDYVTRIMDACYVSAHSGIENLIDRSLIYVSQNQLAMHDLLQQMGWNVVCKESPLEPKRRSRLWISNDIYDVLIENTGAKTLKSMLLDMSRISELELKPEAFVKMRKLKFLKFYHSCGTNSKILLPHGLLSLPDELRYLCWEGYPSKTLPTKFHPRNLVELDMSFSHVEKLWEGKQDLVNLKVMTLNHSENLVKIADLSSATNLETMNLVNCTKLLELPSSLQHLEKLTRLNLRMCKNLRFLPSLYKATSLTTLILSDCSILFSFPEVSSNLRELHLEGTTIEQVPSSMESLSQLVLLSMEDCVRLNNFPTAICSLRSLEVFSLNGSPNITTFPEISGNITELNLGGTAIEEVPSSIECLSNLRVLNLSCCRRLKIVSTSVHKLKSLKTFYLHDCSRLEIFPEILDTMERLRFLDLSGTALKELSSSMENLIGLVELRLNNCENLACLPDNFYKLKSLKFLSLYGCSNLVTWPDNLFSAIGGASLTEMQRDLHGLSSLENLDLSGSNLENLPTSIKQLPRLKQLILRKCKRLKSLPELPPSLKHLDAHDCTSLEEVSSIKKLFEQAVLCKDRPYGFLEWIFSNCFQLDQKAVRNTRTPKLQMLFGHMVTLLKDYHQEFPKINKVITCVPGSEIPEWFDFKSSGSSINIQLPSEWYYNSSKNFPTFVVSTVVSFQEYSGVREIRIRCKCRLKSRNGDCHDLSCSFLTWRERIPGSELIGSDHLFLLYKTCFCDDDAEGGWLVETLASNKGMYNEAWFKFYPLLINWDGSENICCEVKHCGVHISFAKEEAEVQPSKRFKYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PJX0</accession>
    <name>A0A0D2PJX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G002800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PJX0"/>
    <dbReference type="Gramene" id="KJB07164">
        <property type="protein sequence ID" value="KJB07164"/>
        <property type="gene ID" value="B456_001G002800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769604"/>
    <dbReference type="eggNOG" id="ENOG502QU6F">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTTGQTH"/>
    <dbReference type="OrthoDB" id="1908613at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000002">
        <property type="entry name" value="Myb family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044787">
        <property type="entry name" value="HHO5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058673">
        <property type="entry name" value="HHO5-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31003:SF19">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR EFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26575">
        <property type="entry name" value="HHO5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="8">
        <location>
            <begin position="232"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="191"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="41"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="406"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB07164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="441" mass="48705" checksum="3A93FD3275737E23" modified="2015-04-29" version="1">MASSSSSELTLDCKPHGHFAAPSKCYADQQQIVVVNHTLKLEDYLSRLEEERLKIDAFKRELPLCMQLLTNALESSRQQLQAYRANQGPKPVLEEFMPLKTSVSENMDKFQTISDHKANWMTTAQLWSQAGHYETKPQSSSITTSSPKDTDIGLNVVSPKLGSSLDSKQRIGGAFLPFSKDRNSCSTALPDLSLASSDTENGTSCQQRDDGTSNNRTDGQTTNGSNTNQPHRKARRCWSPHLHRRFVNALQMLGGSQVATPKQIRELMKVDGLTNDEVKSHLQKYRLHTRRPSPIPQAAGAPTPQLVVLGGIWVPPEYATAAHSGDPALYGAHHHHHPAVPHAPPHFCASPVPQEFYTTAATPALPPPHHTFHHQLHNMYNARNSPEPDVREAGDRSESIEDGKSESGSWKGESCGDQRIGLAALREEGEESNRSEITLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PX52</accession>
    <name>A0A0D2PX52_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lipoyl synthase, chloroplastic</fullName>
            <ecNumber evidence="11">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase</fullName>
            <shortName evidence="11">LS</shortName>
            <shortName evidence="11">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoate synthase, plastidial</fullName>
            <shortName evidence="11">LIP1p</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">LIP1P</name>
        <name evidence="14" type="ORF">B456_005G213900</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Plastid</location>
            <location evidence="1 11">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="11"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PX52"/>
    <dbReference type="STRING" id="29730.A0A0D2PX52"/>
    <dbReference type="Gramene" id="KJB31908">
        <property type="protein sequence ID" value="KJB31908"/>
        <property type="gene ID" value="B456_005G213900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795000"/>
    <dbReference type="eggNOG" id="KOG2672">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINFTHN"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03129">
        <property type="entry name" value="Lipoyl_synth_plantC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027526">
        <property type="entry name" value="Lipoyl_synth_chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF38">
        <property type="entry name" value="LIPOYL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 11" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0934">Plastid</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="127"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="383" mass="41903" checksum="00634AF3A65C23E4" modified="2015-04-29" version="1">MSVSMSKPSISASIPIPRPRKPSSFSQLKIRCESLDSASKIDVKRPQSSSLSAAGKLMDSDTKNGSYPGGMGPFTGRDPNVKKPEWLRQKAPQGLRFDEVKQSLSRLKLNTVCEEAQCPNIGECWNGGGDGIATATIMVLGDTCTRGCRFCAVKTSRNPPPPDPMEPENTAQAIASWGVDYIVLTSVDRDDLPDGGSGHFAKTVQAMKNLKPDIMVECLTSDFRGDLKAVDTLVHSGLDVFAHNIETVKRLQRIVRDPRAGYEQSLSVLRHAKVSKEGMITKSSIMLGLGETDDELKEALADLRAIDVDILTLGQYLQPTPLHLTVKEYVTPEKFAFWKEYGESIGFRYVASGPLVRSSYRAGELFVKSMVKERANNTTASTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYE9</accession>
    <name>A0A0D2PYE9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G1021002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PYE9"/>
    <dbReference type="STRING" id="29730.A0A0D2PYE9"/>
    <dbReference type="Gramene" id="KJB12014">
        <property type="protein sequence ID" value="KJB12014"/>
        <property type="gene ID" value="B456_002G1021002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1521">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000004">
        <property type="entry name" value="RNA polymerase I subunit 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB12014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="303" mass="34238" checksum="5F66D0E2AACC76B0" modified="2015-04-29" version="1" fragment="single">VRLNEDDMEFDMIGIDAAIANSFRRILIAELPTMAIEKVLIANNTSIIQDEVLAHRLGLVPIRVDPRLFDYLSENDQPNEKNTVVFKLHVQCKRGSPRITVKSDALKWLPNGSELVKETRNATSDSSSKPETYTYFGCSQETIPEFVKNPIIPKYPDIIVAKLGPGQEIELEAHAVKGIGKTHAKWSPVATAWYRMLPEVVLLEDIEDDLAEELKSKCPVNVFDIEDLGKGRRRATVARPRACTLCRECIRGDDWEKRVALRRVKDHFIFTIESTGALPPEVLFTEAVKILEDKCERVITELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZW3</accession>
    <name>A0A0D2PZW3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G027500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mTERF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PZW3"/>
    <dbReference type="STRING" id="29730.A0A0D2PZW3"/>
    <dbReference type="Gramene" id="KJB12619">
        <property type="protein sequence ID" value="KJB12619"/>
        <property type="gene ID" value="B456_002G027500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1267">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVSNYVH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.70.10:FF:000001">
        <property type="entry name" value="Mitochondrial transcription termination factor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.70.10">
        <property type="entry name" value="Transcription termination factor 3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003690">
        <property type="entry name" value="MTERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038538">
        <property type="entry name" value="MTERF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068">
        <property type="entry name" value="CGI-12 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13068:SF166">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR MTERF15, MITOCHONDRIAL-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02536">
        <property type="entry name" value="mTERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00733">
        <property type="entry name" value="Mterf"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="384" mass="44321" checksum="03421F1C9FABA8D4" modified="2015-04-29" version="1">MFYFIIRTSFAYGRQTIAASQSSNLLIFKQSSGLRFFFNSSNGRSFAASYLINKCGFSPEMASRVSNYVHFETPEKPDSLIAFLESHGFSNTQIVNLIKRQPLLLVLDAEKSLSPKLEFLYSIGFSRPELAKLLSNYPRLLTSSLEKQIIPSFDLLRNLFQSHDKTIKAIKRYTGVLAYDPESYLYPNMNVLRGIGVPESNILTLLNCQPRSLLFNPVRLKEIVEEVKRMGIDSSRKKFLVAVYAFRSMSKSTLEKKIDVYRRWGWSDQAINEAFRRYPMCMTVSEDKIMSTMDFLVNKMGYSLTRIAKQPSFLTRSLEKRIMPRALFARELISQGLVNEFKLSVLFDASEKVFIRMYIDRFVNKAPELLKLYKEKLKISGKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q0W9</accession>
    <name>A0A0D2Q0W9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ycf2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G189400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q0W9"/>
    <dbReference type="STRING" id="29730.A0A0D2Q0W9"/>
    <dbReference type="Gramene" id="KJB10211">
        <property type="protein sequence ID" value="KJB10211"/>
        <property type="gene ID" value="B456_001G189400"/>
    </dbReference>
    <dbReference type="OMA" id="CFFGYSS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056777">
        <property type="entry name" value="Ycf2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05695">
        <property type="entry name" value="Ycf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ycf2 N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="111" mass="13185" checksum="EA8D33F79602E057" modified="2015-04-29" version="1" fragment="single">SNSSFLQAERTKIELDRFPKCFFGYSSMSGLFTEHEKRMDDHLLPEEIEEFLRNLTRSIRSLFSDRWSELHLGVNLTERSTRDQKLLKKEQDVCLNIKEIFKPSILNSFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q8F7</accession>
    <name>A0A0D2Q8F7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G062100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8F7"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8F7"/>
    <dbReference type="Gramene" id="KJB13186">
        <property type="protein sequence ID" value="KJB13186"/>
        <property type="gene ID" value="B456_002G062100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778300"/>
    <dbReference type="eggNOG" id="KOG2764">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903189">
        <property type="term" value="P:glyoxal metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="46"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="3">
        <location>
            <begin position="252"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="434" mass="46331" checksum="CD8BC05A0AF5B9B5" modified="2015-04-29" version="1">MAVLHLRHLTHHSLLSTSKLHHHFRFSPLKSPRFSCSASASSTMAKQVLVPIANGTEPMEAVITIDVIRRSGADVTVASVEKELRVDACHGVKIVADALVADCKNTVFDLIALPGGMPGASNFKDCGALESLVKKQAADGRLYAAVCASPAVALGSWGLLKGLKATCYPSFMEQLQSCATAVESRVQQDGKVVTSRGPGSTMEFAVTLVEQLYGKEKADEVSGPLVMRPNHGDEYTITELNPLEWKCNNVPQVLVPIADGSEEMEAVMIIDILRRAKANVVVASVGDNLEILASRKVKLVADMLLDEAAKLTYDLVVLPGGLGGAQAFAKSDKLVNLLKKQAESNKPYGAICASPALVLEPHGLLKGKKATAYPAMCDKLSDQSHIDNRVVVDGNLITSRGPGTSMEFALGIVEKFFGRPKALELAKGLLVVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QCP6</accession>
    <name>A0A0D2QCP6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G140200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QCP6"/>
    <dbReference type="STRING" id="29730.A0A0D2QCP6"/>
    <dbReference type="Gramene" id="KJB14721">
        <property type="protein sequence ID" value="KJB14721"/>
        <property type="gene ID" value="B456_002G140200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1354">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1737">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKLANAP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB14721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="207" mass="23468" checksum="499C45ECA4F58555" modified="2015-04-29" version="1">MSYQPCDSERELLPGTELKEEWKLANAPKNDKFQYTHFVHKINSFDTAPNKLLASDSRLRPDRYALEQGDLSKAGFEKSSDGETFISADDLRINLLNLEISNQSFNIVDVKPANMEDLTGKPILFWYFSLLLSLLKAYASSVLFNIFAKVMVIVMSIIAKVITSADFHPTHCNMLAYSSSKGSIRLIDLRQSALCDSHAKLQVFYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJ41</accession>
    <name>A0A0D2QJ41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G012200</name>
        <name evidence="6" type="ORF">Gorai_020291</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DENR family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0577987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2QJ41"/>
    <dbReference type="STRING" id="29730.A0A0D2QJ41"/>
    <dbReference type="Gramene" id="KJB07270">
        <property type="protein sequence ID" value="KJB07270"/>
        <property type="gene ID" value="B456_001G012200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3239">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF6">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="100"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB07270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0577987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="212" mass="23838" checksum="0C9AC1D33E6BAF14" modified="2015-04-29" version="1">MAEKPQPVVVQYCQVCGLPAEYCEFGSEFDKCKPWLIQNAPDLYPDLLKEANAKEADKVADQLQSTGISSADSGSSSEAKQEEVKRLPGGKIKKKEKKEVVIEKVVRNKRKCITTVKGLELFGVKLSDASKKLGKKFATGASVVKGPTDKEQIDVQGDISYDIVEFITETWADVILITFWPFLMFYANLHFSPFLCFKFNDQLHIGRLFLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLE3</accession>
    <name>A0A0D2QLE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G230000</name>
        <name evidence="8" type="ORF">Gorai_012517</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLE3"/>
    <dbReference type="STRING" id="29730.A0A0D2QLE3"/>
    <dbReference type="Gramene" id="KJB58857">
        <property type="protein sequence ID" value="KJB58857"/>
        <property type="gene ID" value="B456_009G230000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771312"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PVRAEMM"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ACT-like_dom_sf"/>
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        <property type="entry name" value="AIG1-like"/>
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        <property type="entry name" value="HLH_DNA-bd_sf"/>
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        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45844:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH30-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="36"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0595656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="230" mass="25624" checksum="F60839B639C0E3F5" modified="2015-04-29" version="1">MFPVKSFSGVENNNSPVMLMEGEDSLKDLSERKTMEACKSHKEAERRRRQRINAHFSTLRSVLPNTTKTDKASLLAEVVHHVRELKRQVEDVGRRDRDGCCSNSRPELDTSWPFPGECDEATLSFCDEGGKLLKATICCEDRPGLNHDLSRVIRLVQAKVVRAEMTTVGGRTKSVVVMQWSGDEEQVGPLKRALKDVVENRVSRLAQGTGSKRARVFGSNSETGHGFLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLX9</accession>
    <name>A0A0D2QLX9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amine oxidase</fullName>
            <ecNumber evidence="9">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_003G166200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="9">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="8">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8 9">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="9"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLX9"/>
    <dbReference type="STRING" id="29730.A0A0D2QLX9"/>
    <dbReference type="Gramene" id="KJB20809">
        <property type="protein sequence ID" value="KJB20809"/>
        <property type="gene ID" value="B456_003G166200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1186">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVIRVQC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009733">
        <property type="term" value="P:response to auxin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009753">
        <property type="term" value="P:response to jasmonic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904585">
        <property type="term" value="P:response to putrescine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009751">
        <property type="term" value="P:response to salicylic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009414">
        <property type="term" value="P:response to water deprivation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000004">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF69">
        <property type="entry name" value="AMINE OXIDASE [COPPER-CONTAINING] GAMMA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0801">TPQ</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="12">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="13">
        <location>
            <begin position="143"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="11">
        <location>
            <begin position="267"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="7">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="8">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB20809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="682" mass="76851" checksum="93E260393D97B031" modified="2015-04-29" version="1">MEKTSCLHFCFISCLVLFIIVGSWYRSSISSLPGYSLQTQKPIDHSAKTPYHPLDPLTVKEINRVRTILSSYEPFSFTFPTIHTILLDEPDKVQVLKWRKGDPFPPRKAQVLALLNGQSHVLNVDLDSRRVTGHAINPSSGYPVLSMDDISAASKAPFSNAEFNKSIAARWVSSSELICLPPSAGWFGPNEEGKRVVKVLCFSNQGTPNFYMRPIEGLVMTVDLDTLEVLKFSDTGRDIPIPKSADTDYRYTAQKKEQKMEPLNPISIEQPKGRSFRVEDGHIVKWANWVFHLKADHRAGLVISRVMVRDSENGELRDVMYRGFASEFFVPYMDLDESWYFKSYMDAGEYGLGMSALPLVPLNDCPRHSYYMDGIFATPDGNPFVQPNMICLFERYAGDISWRHSDGLLTDFQIREARPKVTLVARMAASVGNYDYIFDWEFQTDGLINVKVGLSGMLMVKGSPYHQAPNQDAMSGPLISENLIGVVHDHFVTFHLDMDIDGANNSKSYLKAKRKIAKTEKDAQIKLILYDPSELHMINPSKRSRLGNPTGYKIVPGGTAASLLDHDDPPQLRSAFTNNQIWVTPYNKSEQWAGGLLTYQSRGDDTLAVWSERDRSIENKDIVLWYTLGFHHIPCQEDFPVMPTVTSGFELKPVNFFESNPILRAAPAFEKDLPVCRSSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNP8</accession>
    <name>A0A0D2QNP8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G266200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNP8"/>
    <dbReference type="STRING" id="29730.A0A0D2QNP8"/>
    <dbReference type="Gramene" id="KJB59662">
        <property type="protein sequence ID" value="KJB59662"/>
        <property type="gene ID" value="B456_009G266200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770102"/>
    <dbReference type="eggNOG" id="ENOG502S3U7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SEVWEDM"/>
    <dbReference type="OrthoDB" id="1849108at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF45">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF042-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="9">
        <location>
            <begin position="12"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB59662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="147" mass="16096" checksum="C846D5A54C90ECB1" modified="2015-04-29" version="1">MSADGSSADQRKYKGVRRRRWGKWVTEIRVPGTEGRLWLGSYSTPEAAAVAHDIAFYCLRRPSSLTALNFPSMLPPHVNSNMSPKSVQKAASDAGMAVDAQMILVDSPMNDEIKANTNDGSSCGGGSWERSEGRERETLSISIEDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QY22</accession>
    <name>A0A0D2QY22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab3GAP catalytic subunit conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G440800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QY22"/>
    <dbReference type="STRING" id="29730.A0A0D2QY22"/>
    <dbReference type="Gramene" id="KJB62862">
        <property type="protein sequence ID" value="KJB62862"/>
        <property type="gene ID" value="B456_009G440800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768463"/>
    <dbReference type="eggNOG" id="KOG2390">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045700">
        <property type="entry name" value="Rab3GAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026147">
        <property type="entry name" value="Rab3GAP1_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21422:SF10">
        <property type="entry name" value="RAB3 GTPASE-ACTIVATING PROTEIN CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13890">
        <property type="entry name" value="Rab3-GTPase_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab3GAP catalytic subunit conserved" evidence="2">
        <location>
            <begin position="368"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB62862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="689" mass="77251" checksum="1823C35A3E39ACFA" modified="2015-04-29" version="1">MAAPSFVSKARTAFNSAAAKAERVFTDFKPDFDSDKLLRKEFKNESLNEGESKSFDEVKNSRWRPSNLGTKQEWQERFRKLRIGRKGIEDTEKVEISIMAVPFYDENIYLLNMKNDTEAKLLEAIPSVDVLNTTNTNSIPPTSVLKQLAVAIEAGKNFKTVKDLLASFGNSSPSKEKPGLSFSTVKSLVIREKEDKLASGFGDDKKVLALINSLFDADGKFLQRKLVSDSNTCTPKIPFIKDIHGAPPHGFVVKLSEVIGSFRSLHKMALFWCRVVIELRRFWSEEKHLPGIPVNEIPDLNSCLLYQQLQVINCCLSRKRQHYIATESFDSEMMEAGSNFKESDVSKGTVSAGSALFARLKTGELVLRQGANQLIENLAMLETGEPMYSPITQEGPLLTEDLIRETEELVLRTGSVGAGCSRLLSDMQAFKAANPGCVLEDFVRWHSPPDWIEDEPSDKVPGARGQLSSRMQKGGNLWRELWETSKPVPAIKQTPLYDEDLAVDGILNFFENIPISELFQQLFLALLSLGFVLAEDKLSANENLSKLFYECKDYVVATCQRNTWNDKVDDLCQVYETVETMLVSPEEVIKAIKQADETPTQENESPTRGELKLRFLRLGLNFGNKDKQQKKTPTTTKEPKKNADENPSRPFASFFDTKSSLFAKMSPKAKNLPQVDKPPAIDESNLTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYM0</accession>
    <name>A0A0D2QYM0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G246100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYM0"/>
    <dbReference type="STRING" id="29730.A0A0D2QYM0"/>
    <dbReference type="Gramene" id="KJB44323">
        <property type="protein sequence ID" value="KJB44323"/>
        <property type="gene ID" value="B456_007G246100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQZU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YWSLVPE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36350">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36350:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB44323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="357" mass="41307" checksum="E265589FBB9017E8" modified="2015-04-29" version="1">MFSIKASSFIYQTEFHTPKFPNLKPSKTLSPLFTPSLKPNNLSFQTTRLRSSYNPTSILPTKLPCVSPKTQFFNSLSEKVVVFLVGSFIFLGCFNAKPCLALPAQATTSSRVNLEGKNETQKRKSEEEERYEKILEKEPRNVDALKVLLYGKIRRGKTQEAVECVEKLIDIEPDEVEWRLLQALCYEMMGQLSKAKRLFKEILEETPLLLRALHVKFSNLGLAMVMHKNHEGPAVFEMLNEALEVAVREKRVTEERNIRVLIAQMHVVKGELEEGMKKFQDLIKDNPRDFRPYLCQGIIYSLLDKKKEAAEQFEIYQSLVPEEFPQRGFLDDVVLEAKTKSRKWLQKDFKAEFSYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYP8</accession>
    <name>A0A0D2QYP8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G014500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYP8"/>
    <dbReference type="STRING" id="29730.A0A0D2QYP8"/>
    <dbReference type="Gramene" id="KJB12355">
        <property type="protein sequence ID" value="KJB12355"/>
        <property type="gene ID" value="B456_002G014500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2275">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GETCIEV"/>
    <dbReference type="OrthoDB" id="1883156at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="379" mass="41623" checksum="56C697127E5FBAE6" modified="2015-04-29" version="1">MALSAPSTLISHNRAVNCLAFSLPKLGNLAVNHQQLHSRVNFHSFSDPPYVHQCRNGGKFQPSCLAKTVVSDVGVHNSDFTTDAAADDTWSEFAKNVSGEWDGFGADFTIEGKPIELPESVVPEAYREWEVKVYDWQTQCPTLAEPVENTMTYKTIKLLPTVGCEADAATRYSIEEKNIGGVDNEVSAFAYHSSGCYTAIWSVADKNLLELEHCLINPRDRESRVRIIQVVRVDGTKFVLQNVRVFCEQWYGPFRNGDQLGGCAIRDSAFASTAATNASDVGGVWKGSNAAASFDSSGDNFLEELKANGVMKSIRDGSNLILLPKQLWCSLMDSGGETCIEVGWLYDQGYAITSRCCFSREGKLKEVSIARETTVLEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZH8</accession>
    <name>A0A0D2QZH8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G259700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZH8"/>
    <dbReference type="STRING" id="29730.A0A0D2QZH8"/>
    <dbReference type="Gramene" id="KJB44563">
        <property type="protein sequence ID" value="KJB44563"/>
        <property type="gene ID" value="B456_007G259700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804442"/>
    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="6">
        <location>
            <begin position="149"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="204"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="263"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="314"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="4">
        <location>
            <begin position="368"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="849"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="966"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="849"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB44563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117402" checksum="8FC442D17A2DEB2F" modified="2015-04-29" version="1">MFNSPQGHKQSLQKSMRKVSPGASHKDLWLTVREGSLPDVDSVLALLKKAGGNINSRNSFGLTPLHIATWRNNIPVIRRLLAAGADPDARDGESGWSSLHRALHFGHLAVASVLLQSGASITLEDSKCRTPVDLLSGPVLQVFESAQDSVATEVFSWGSGVNYQLGTGNAHIQKLPCKLDSFHGSKIKLVSAAKFHSIAVTARGEVYTWGFGRGGRLGHPDFDIHSGQAAVITPRQVTSGLGAHRVKAIAAAKHHTVIATEGGDVFTWGSNREGQLGYTSVDTQPTPRRVSSLRSRIVAVAAANKHTAVVSASGEVFTWGCNREGQLGYGTSNSASNYTPRIVEYLKSKVFVGVATAKYHTIVLGADGEVYTWGHRLVTPRRVVITRTLKKSGSTPLKFHRKERLHVVAIAAGMVHSIAMTEDGALFYWVSSDPDLRCQQLYSLCGKKMVSISAGKYWAAAATATGDVYMWDGKQSTDKRPVATRLHGIKRATSVSVGETHLLTIGSLYHPVYPPSMPKSDKAPKLKVNDEVEEFDEECMFDDLESSSITSAHKNDSEQKPIPSLKSLCEKVAAECLVEPRNAIQLLEIADSLGADDLKKHCEDIIIHNLDYILTVSSQAFASASPDVLANLEKSLDLRSSESWSYRRLPTHTATFPVIINSEDEDSEREVLRTRNNNKNKNPLENGDRLDSFLQPKDDPNLGISKQVRALWKKLQQIEVLEEKQLSGCILDDQQIAKLQTRAALENSLAELGIPVERSHLKGSCSILSDGKGNKMAEVSRKQRRKSKQRVSQVETVSGFCTTNKEPNSVKGFSDVENPQVLMTKEENRGCEGATQNQASIESRFFVQKKDSSVPAKDKGTSQTATKKKNRKGGLSMFLSGALDDSPKQVTPLAPTPRSEGPAWGGAKVSKGSASLREIQDEQSKIQVNQKTGSKNQVEDLFAGKSEGKILLSSFLPSKPIPVVSVQTSQASDAERSTPPWASSGTPPHLSRPSLRDIQMQQQGKQLHGLSHSPKMKMSGFSVASSQGSPSDTPGVNRWFKPEIEAPSSIRSIQIEERAIKDLKRFYSSVKVVKNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R1C3</accession>
    <name>A0A0D2R1C3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein DETOXIFICATION</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Multidrug and toxic compound extrusion protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G208200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R1C3"/>
    <dbReference type="STRING" id="29730.A0A0D2R1C3"/>
    <dbReference type="Gramene" id="KJB25774">
        <property type="protein sequence ID" value="KJB25774"/>
        <property type="gene ID" value="B456_004G208200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1347">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKFCLYQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11206">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="528"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB25774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="601" mass="66275" checksum="E56B972BF3AA8227" modified="2015-04-29" version="1">MERLYSQFQVKNPFKTHILFPFFQPPPSLHWLSLLQTIIPKFLSGLPLVLFLLSFSHRTIKKKCRIMGGFSSSCKQSLDHENLATIIVQESDMLSTPLNLKIPTEQRQDMTSEKTCLSPIIGELNCIANVAFPMVLTGLLLYSRSMISMLFLGRLGELALAGGSLAIGFANITGYSVLSGLAMGMEPICGQAFGAKRFKVLGLTMQKMILMLLLTSIAIASLWFSMKNILLFCGQDENIANEAQSYILYSLPDLLAQSILHPLRTYLRTQSITLPLTYCSTLAILLHIPINYLLVSVLNLGIKGVALGSVWTNFNLVGSLIVYVKISGVYKKTWGGISSDCFKGWKYLLNLSIPSCISVCLEWWWYEIMILLCGLLLNPQATVASMGILIQTTSFIYIFPSSLSFGVSTRVGNELGANNPNKAKIAAIVGLSSSSVLGFSAFVFTILIRKKWAAMFTQDPEIIALTSMVLPILGLCELGNCPQTTGCGVLRGTARPKLGANINLGCFYLVGMPVAVWLSFFTGFDFKGLWLGLLAAQGSCLLTMLFTVTRTDWDFQAWRAQELTREVPVDDDDHTNQDGSMKESSGLLHHDIKQKQLTCLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R430</accession>
    <name>A0A0D2R430_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G134600</name>
        <name evidence="10" type="ORF">Gorai_014700</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WRKY group III family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R430"/>
    <dbReference type="SMR" id="A0A0D2R430"/>
    <dbReference type="Gramene" id="KJB24221">
        <property type="protein sequence ID" value="KJB24221"/>
        <property type="gene ID" value="B456_004G134600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791359"/>
    <dbReference type="eggNOG" id="ENOG502QPRM">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1888929at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010193">
        <property type="term" value="P:response to ozone"/>
        <property type="evidence" value="ECO:0007669"/>
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            <dbReference type="PROSITE" id="PS50811"/>
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</entry>
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    <accession>A0A0D2R5Z7</accession>
    <name>A0A0D2R5Z7_GOSRA</name>
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            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
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    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="ERF_plant"/>
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        <property type="entry name" value="ETHRSPELEMNT"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
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        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0584115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="244" mass="27086" checksum="54B23C10F459EAAD" modified="2015-04-29" version="1">MNVEILSESDFNILESFQRFFDGFDESPPPPPTTTPTCDNFVLQPSYNRCLSFSGVFLNENWGDLPLKIDDSEDMLVYSTLRDAANSGWSPSNEADSTTVSSEACSEGKEKLMEVVEREPNVLLPPSSRRGTNFKGVRRRPWGKYAAEIRDPKRNGARIWLGTYETPEDAALAYDKAAFKMRGAKAKLNFPHLIGSSYCEPIRVGSRRRSLEPPSASTTSPKRMKSTAAVTNSTAPTEVIQMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R622</accession>
    <name>A0A0D2R622_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G166300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R622"/>
    <dbReference type="STRING" id="29730.A0A0D2R622"/>
    <dbReference type="Gramene" id="KJB24891">
        <property type="protein sequence ID" value="KJB24891"/>
        <property type="gene ID" value="B456_004G166300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791701"/>
    <dbReference type="eggNOG" id="KOG2945">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NHGAPAR"/>
    <dbReference type="OrthoDB" id="784393at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF78">
        <property type="entry name" value="RGG REPEATS NUCLEAR RNA BINDING PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="153"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB24891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="361" mass="39014" checksum="E72127FD66469BD3" modified="2015-04-29" version="1">MAGLNPFDLLGDDDTGELSLLIAAQQKAVAAATATAAAPKKGPAKPQAKTLPATQAKLPSKPLPPTQAVREAKNEGARGGGRGGRGYGRGRGGSSGYRRDFANDENSFSNSAVPEDGESGKPSERRGYGGPRPYRGGRRGGFSNGEDADGEQPRRLYERRSGTGRGNELKREGSGRGNWGTQTDELAQVTEVTNEGERNLGDEKPAGEEDAREANKESASNEPEEKEPEDKEMTLEEYEKVLEEKRKALQALKIEERKVDAKEFESMQQLSNKKNNDEVFIKLGSDKDKRKEAYEKEERAKKSVSINEFLKPAEGERYYNPSGRGRGRGRGSRGFGGGSAARDVAAPSIEDPGHFPTLGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R683</accession>
    <name>A0A0D2R683_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_010G115800</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R683"/>
    <dbReference type="SMR" id="A0A0D2R683"/>
    <dbReference type="STRING" id="29730.A0A0D2R683"/>
    <dbReference type="Gramene" id="KJB65837">
        <property type="protein sequence ID" value="KJB65837"/>
        <property type="gene ID" value="B456_010G115800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773137"/>
    <dbReference type="eggNOG" id="KOG1712">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVEPCER"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000022">
        <property type="entry name" value="Adenine phosphoribosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050120">
        <property type="entry name" value="Adenine_PRTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11776:SF22">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="55"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB65837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="193" mass="20999" checksum="E8A50DE3CDF8A60C" modified="2015-04-29" version="1">MVEMFAAENGLKGDPRLQAISNAIRVVPHFPKQGIMFQDITTLLLDHKAFKNTVDIFVDRYKDMNISVVAGVEARGFMFGPTIALAIGAKFVPLRKPKKLPGEVIAEAYELEYGSDCLEMHVGAVEAGERAIVIDDLVATGGTLSAAISLLERVGAEVVECACVIGLREVKGQRRLNGKPLYILVEPREIDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R865</accession>
    <name>A0A0D2R865_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G147000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="56"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="255" mass="28945" checksum="1353F1BF7CE1EAB5" modified="2015-04-29" version="1">MAYYSSNYYYEANSEFNEPEFEEYDPTPYGGGYDLDATYGKPLPPSEGICYPRSSGDPNDQSLKTFSYGSIESPYGKGVDKLVEKPSNGSKTATVKDQEQQTQGSNEAVNVDSNGKPLESYQGEEIKESYTDGYPSNRNVAIGDANGAEYEKRVSQIPPGYGLEAMDLCESLFGYWPCLDRAKRENEYRNCYGPQGVNCPWEETADYLFGNSYPYGERWGNGGIYENPIFNYERHYQGQLISRQMEYQEEHSWLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R987</accession>
    <name>A0A0D2R987_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G195200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R987"/>
    <dbReference type="STRING" id="29730.A0A0D2R987"/>
    <dbReference type="Gramene" id="KJB15770">
        <property type="protein sequence ID" value="KJB15770"/>
        <property type="gene ID" value="B456_002G195200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785891"/>
    <dbReference type="eggNOG" id="KOG1303">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WIGAYTI"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48017">
        <property type="entry name" value="OS05G0424000 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="227"/>
            <end position="249"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
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            <end position="285"/>
        </location>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
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            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="38"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RC72</accession>
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        <recommendedName>
            <fullName evidence="10">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
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        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
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        <property type="protein sequence ID" value="KJB48833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2RC72"/>
    <dbReference type="Gramene" id="KJB48833">
        <property type="protein sequence ID" value="KJB48833"/>
        <property type="gene ID" value="B456_008G089400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0023">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESNCESM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB48833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37588" checksum="82560BFEE4252BE9" modified="2015-04-29" version="1">MNPTMTRLAEEEHPNKAFGWAARDSSGVLPPFKFSRRATGENDVAFKVLYCGICHSDLHMAKNEREHEIVGEVTEVGSKVQKFXXXXXXXXXXXXXXXXXXXXXXNNLENYCPKSILTYGAEYHDGSITYGGYFDTMVADEHFIVRIPDNLPLDVATPLLCAEITVYSPLRYYGLNKPGLHVGVVGLGGLGHVAVKFAKAMGAKVTVISTSPSKKKEALENLGPDSFLVSRDQDQLQGASGTLDGIIDSVSAQHPLFPLLGLLKSHGKLVLVGAPEKPLELPVFPVLQGWKVVAGSMTGGMKETEEMIDFAAKHNVKPDIEVIAMEYVNTAMERLLKAQLKATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDT1</accession>
    <name>A0A0D2RDT1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G174400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDT1"/>
    <dbReference type="STRING" id="29730.A0A0D2RDT1"/>
    <dbReference type="Gramene" id="KJB68667">
        <property type="protein sequence ID" value="KJB68667"/>
        <property type="gene ID" value="B456_010G174400"/>
    </dbReference>
    <dbReference type="OMA" id="DNCLFAM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040256">
        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025558">
        <property type="entry name" value="DUF4283"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF178">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14111">
        <property type="entry name" value="DUF4283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4283" evidence="1">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="206" mass="24821" checksum="EDE7D696ED7761FB" modified="2015-04-29" version="1">MAIEKPNREAMYKVLRSLWLTKYEVNFVALNEEMIMVKFGYVEDRNRILNMMSWLFDNCLFAMFPFVKDKELETYEFNFSSFWLQIYNIPLEYMERQIAMDVGKAIGELVAIDWKDRNGGWTEVMRLKVKINVSNLLRRVVRKQIGYEGIRWKKVYKKEREKSTLKIRCLTLRWKKEPQNRHDVGLSGGKFKRAKWRFGHAVEGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIL3</accession>
    <name>A0A0D2RIL3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G077400</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIL3"/>
    <dbReference type="STRING" id="29730.A0A0D2RIL3"/>
    <dbReference type="Gramene" id="KJB70527">
        <property type="protein sequence ID" value="KJB70527"/>
        <property type="gene ID" value="B456_011G077400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777747"/>
    <dbReference type="eggNOG" id="ENOG502QSS9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFNAMPN"/>
    <dbReference type="OrthoDB" id="660348at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="121"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="461"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="629"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB70527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="687" mass="74828" checksum="017EEC407B464416" modified="2015-04-29" version="1">MATTGEDEVEYYSDPEEVKCSLTMQRRKAASDDEEGEGEVDNNNAVRMNPRAVIHSDESDSQGGAADYDDEEEELYSEEEEEEENYDGVEEEDVDEEEIEEVMRRREVQGNAERTGGAAVMDNGNRNVDEGVEISNGNNHVGEEDEDEKKENEPFVVPTAGAFYMHDDRFRDNVGGRHRQMRGGRKLWESKDDRKWGHDKFEEMTLQGKRYKEGRRSSRGRYRARSKNAVQDHGYSTGSRSKAFGKNYNQNQAPKAVRGRGPKRYEPTMKNGCQASPVLNKPSWKPIEKTSQANSSRASTTATNADTVSIPSKKHIFASSLSSASPPFYPSGSSKKDISLTQRKDAQAGSVSRDLRPSVTDEKFSLFQSNSLRGKNVLDPLGMAKLYIDDSTTSASVKPLANMQMLPTGSSLGNTSQPSQSRVQGRVIANPGPKAYQPAPHHNQVNRVSPPVQVNAVQRIPAQGRAHSSVQAATQQLGQHPSIGSQAASPPKTAMSVSSYESGEVESSETSKPEGALVNKGKSNLQGAGRGSYLYGGAQIIGATGNMSISHGDQNFPAFLPVMQFGGQHSGGLSVPAVGMAFPGYVAQPQLGTRNSEMTWLPVLTGAAGALGPTYCPPYIAVDGAYNARPSGQTSSTGSSSKENISKKPNNEWKPSQRPELVSDELGQRQNNPNKQPRRYSEMSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQ91</accession>
    <name>A0A0D2RQ91_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G0861001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQ91"/>
    <dbReference type="STRING" id="29730.A0A0D2RQ91"/>
    <dbReference type="Gramene" id="KJB21274">
        <property type="protein sequence ID" value="KJB21274"/>
        <property type="gene ID" value="B456_004G0861001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21275">
        <property type="protein sequence ID" value="KJB21275"/>
        <property type="gene ID" value="B456_004G0861001"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21276">
        <property type="protein sequence ID" value="KJB21276"/>
        <property type="gene ID" value="B456_004G0861001"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
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    </dbReference>
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        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB21275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="33" mass="3580" checksum="9BEF94DF23655B05" modified="2015-04-29" version="1" fragment="single">TIESTGALPPEVLFTEAVKILEDECECVITELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RQK9</accession>
    <name>A0A0D2RQK9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_006G051700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RQK9"/>
    <dbReference type="Gramene" id="KJB34169">
        <property type="protein sequence ID" value="KJB34169"/>
        <property type="gene ID" value="B456_006G051700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB34169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="15928" checksum="12BECE2D624E8FAB" modified="2015-04-29" version="1">MYLNFIPGVRNKGSISSTSVSEFFLFRIIFGLDKKIIEINQFIRKNKSQLPQGWASCDNKGLPIVDRINRGSTRDYRGMLLLLAMVHKEGPTVTMVRRRVVGRMVPGSAWCEGTRLVCCGAIGCARAFFYGIARARRVRAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRQ4</accession>
    <name>A0A0D2RRQ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit C, plastid</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP synthase F0 sector subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_011G232000</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is one of the chains of the nonenzymatic membrane component (F0) of mitochondrial ATPase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRQ4"/>
    <dbReference type="STRING" id="29730.A0A0D2RRQ4"/>
    <dbReference type="Gramene" id="KJB73407">
        <property type="protein sequence ID" value="KJB73407"/>
        <property type="gene ID" value="B456_011G232000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0232">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NPQMAGK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18183">
        <property type="entry name" value="ATP-synt_Fo_c_ATPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit c, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005608">
        <property type="entry name" value="PRK07354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF48">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT C, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 18" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="11 18" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 18" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0793">Thylakoid</keyword>
    <keyword evidence="8 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 18" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="19">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB73407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="81" mass="8090" checksum="BE4CCDDEE7E0F9C4" modified="2015-04-29" version="1">MNPLISSASVIPVGLVVGLASIGLGVGQGTAAGEAVEGIARQPEAEGKIRGTLLLSLAFMEALTIYGLVVALALLFVNPCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTS8</accession>
    <name>A0A0D2RTS8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_011G275900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTS8"/>
    <dbReference type="STRING" id="29730.A0A0D2RTS8"/>
    <dbReference type="Gramene" id="KJB74152">
        <property type="protein sequence ID" value="KJB74152"/>
        <property type="gene ID" value="B456_011G275900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775768"/>
    <dbReference type="eggNOG" id="KOG0710">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDTWHRT"/>
    <dbReference type="OrthoDB" id="1431247at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06472">
        <property type="entry name" value="ACD_ScHsp26_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000009">
        <property type="entry name" value="17.6 kDa class I heat shock protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16450" checksum="D8662AB910F59CA9" modified="2015-04-29" version="1">MAMIPSLFGNNNTTIFDPFSFNMFDPSTETSAAISNTRIDWKETPEAHIFKADVPGLEKEEVKVEVEEGKVLRISGERSVEKEDKNDTWHRTERSSGKFTRRFRLPENVKMDQIKATMENGVLCVVVPKEGEKKREVKNIEICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTV3</accession>
    <name>A0A0D2RTV3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Putative GTP diphosphokinase RSH1, chloroplastic</fullName>
            <ecNumber evidence="2">2.7.6.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RelA/SpoT homolog 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">ppGpp synthetase RSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G051900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RelA/SpoT family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.5" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTV3"/>
    <dbReference type="STRING" id="29730.A0A0D2RTV3"/>
    <dbReference type="Gramene" id="KJB22514">
        <property type="protein sequence ID" value="KJB22514"/>
        <property type="gene ID" value="B456_004G051900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22515">
        <property type="protein sequence ID" value="KJB22515"/>
        <property type="gene ID" value="B456_004G051900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790435"/>
    <dbReference type="eggNOG" id="KOG1157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="430679at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008728">
        <property type="term" value="F:GTP diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000002">
        <property type="entry name" value="GTP pyrophosphokinase (RelA/SpoT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3210.10:FF:000001">
        <property type="entry name" value="GTP pyrophosphokinase RelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43061">
        <property type="entry name" value="GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43061:SF1">
        <property type="entry name" value="GTP DIPHOSPHOKINASE RSH1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13328">
        <property type="entry name" value="HD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="HD" evidence="9">
        <location>
            <begin position="168"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="10">
        <location>
            <begin position="559"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00070102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB22515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="881" mass="98527" checksum="2789371781D54308" modified="2015-04-29" version="1">MAFAPSLSVSVECVNICKFTKGEGSGRYDCSMLSCAWKAPRVLTGFLASTANPSHSSPFGYARHGRRNRIKPAFDVGGWCSTDVSEFILLGKLYRSSVLHVGCKRWQLCSSSSFSSNTSNDISPESLWEGLKPAISYLSSNELELVHNALKLAFEAHDGQKRRSGEPFIIHPVEVARILGELELDWESIAAGLLHDTVEDTNIVTFQRIEEEFGPTVRRIVEGETKVSKLGKLKYKNENDSVQDVKADDLQQMFLAMTEEVRVIIVKLADRLHNMRTLSHMPPHKQSSIAMETLQVFAPLAKLLGMYKIKSELENLSFMYTNPEDYAKVKRRIADLYKEHEKELMEANKILMKKIENDQFLELMTLKTEICAVCKEPYSMYKSVLKSKGSISEVNQIAQLRVIIKPKPSVGVGPLCSSQICYHVLGLVHGIWTPVPRTMKDYIATPKPNGYQSLHTNVIPFLYESMFRLEVQIRTEEMDLIAERGIAAHYSGRVFVTGLVGHAVPNGRNSRGKLVCLNNANIALRVGWLNAIREWQEEFVGNMSSREFVDTITRDLLCSRIFVFTPRGEIKNLPRGATVIDYAYMIHTDIGNKMVAAKVNGNLVSPTHVLANAEVVEIITYNALSSKSAFQRHKQWLQHAKTRSARHKIMKFLREQAALSAVEITTDRVNDFIAYSEEDSEMEDLSHSSRQNRPLWEKILKNIVDFSTPGRSSEDALTAKNGSIWVPKVNGKHNKQVQDVGSKANGYLFSLGNGAAKMIPANNPPHKEVLPGLESWQASKIASWHNLEGHSIQWFSVVCIDRRGMMAEVTTALAAVGITICACVAEIDRGRGMAVMLFHVEANLEILVNACSRLDLILGVLGWSVGCSWPSTIENNQLQNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RW05</accession>
    <name>A0A0D2RW05_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial outer membrane protein porin of 34 kDa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G024700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin (TC 1.B.8.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RW05"/>
    <dbReference type="STRING" id="29730.A0A0D2RW05"/>
    <dbReference type="Gramene" id="KJB33661">
        <property type="protein sequence ID" value="KJB33661"/>
        <property type="gene ID" value="B456_006G024700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798259"/>
    <dbReference type="eggNOG" id="KOG3126">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGMFVPH"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Outer mitochondrial membrane protein porin"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
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    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF60">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN PORIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
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        <property type="entry name" value="Porin_3"/>
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        <property type="entry name" value="EUKARYOTIC_PORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009624"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB33661.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29562" checksum="B80DDA00E58318D6" modified="2015-04-29" version="1">MGKGPGLYTEIGKKARDLLYKDYQTDHKFTLTTSSPTGVAITSAGTKKGELFLADVNTQLKNKNVTTDIKVDTYSNLYTTITVDQPAPGLKAIFSFRVPDQRSGKVELQYLHEYAGISSSIGLTANPIVNLSGVIGTNVLALGTDLSFDTKTGNFTKCNAGLSFSNVDLIASLTLNEKGDSLNASYYHIVNPMTNTAVGAEVTHSFSTNENTITIGTQHALDPLTMVKARVNNAGNASALIQHEWRPRSLFTISGEVDTKSIDKSAKVGLALALKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1Q4</accession>
    <name>A0A0D2S1Q4_GOSRA</name>
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        <recommendedName>
            <fullName evidence="11">General transcription factor IIH subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_006G120700</name>
        <name evidence="16" type="ORF">Gorai_000799</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2S1Q4"/>
    <dbReference type="Gramene" id="KJB35568">
        <property type="protein sequence ID" value="KJB35568"/>
        <property type="gene ID" value="B456_006G120700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35571">
        <property type="protein sequence ID" value="KJB35571"/>
        <property type="gene ID" value="B456_006G120700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35572">
        <property type="protein sequence ID" value="KJB35572"/>
        <property type="gene ID" value="B456_006G120700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB35573">
        <property type="protein sequence ID" value="KJB35573"/>
        <property type="gene ID" value="B456_006G120700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799309"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="vWA_transcription_factor_IIH_type"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="General transcription factor IIH subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="C1-like_sf"/>
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    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
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    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="84"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB35571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0587676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="413" mass="45806" checksum="3F8680ECC236D4D6" modified="2015-04-29" version="1">MNNGAGRRINGGAEEDDDEDDVNGDLDAWERTYTDERSWESLQEDESGMLRPIDNQALYHSQYRRRLRSLSSTAARIQKGLIRYLYIVIDLSRAASEMDFRPSRIAVIAKHVETFIREFFYQNPLSQVGIVTIKDGVAHCLTDIGGSPESHINALMKKLECSGDSSLQNALDLVDGYLNQIPSYGHREVLILYSALSTCDPGDIMDTIQKCRKSKIRCSVIGLAAEMFICKHLCQETGGTYSVALDESHFKELILEHAPPPPAIAEFAVANLIKMGFPQRAAEGSISICSCHKEAKVGAGYTCPRCKARACELPTECCVCGLTLVSSPHLARSYHHLFPIAPFDEVTSSHLNNPNCKLQRNCFGCQQSLLDPGNKPGPAVVCPKCKRYFCLDCDIYIHESLHNCPGCDSLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3M7</accession>
    <name>A0A0D2S3M7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aluminum-activated malate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_006G149200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aromatic acid exporter (TC 2.A.85) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3M7"/>
    <dbReference type="STRING" id="29730.A0A0D2S3M7"/>
    <dbReference type="Gramene" id="KJB36261">
        <property type="protein sequence ID" value="KJB36261"/>
        <property type="gene ID" value="B456_006G149200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799616"/>
    <dbReference type="eggNOG" id="KOG4711">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IFAKWEP"/>
    <dbReference type="OrthoDB" id="68611at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015743">
        <property type="term" value="P:malate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020966">
        <property type="entry name" value="ALMT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31086">
        <property type="entry name" value="ALUMINUM-ACTIVATED MALATE TRANSPORTER 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11744">
        <property type="entry name" value="ALMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB36261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53866" checksum="88F82C260925902E" modified="2015-04-29" version="1">MDIDSTAQDKARFFAGAWGRVKALPGKLKAKVTSTAKSIKRLGQDDPRRLTHSLKVGLALTLVSLLYYARPIYDGFGVSGMWAVLTVVVVFEFTVGGTLSKSLNRGFATFLAGALGLGADYFASLFGKNGEPIVLGILVFLLAAAATFSRFFPRIKARYDYGVLIFILTFSLVAVSGYRVNELVVLAHQRLSTIIMGGATCMLISIFVCPVWAGEDLHKAIASNLEKLATYLEGFGGVYFQSSESDGMGTGKSFPQGYKSILNSKSNEESLANFARWEPGHGRFRLRHPWKHYLKIGALARQCAYQIEAINGCIGSDHIQGSEEFKGKIEGSCTRMSAECGKTLKALARSMKTMTDPYSSANTHVENSKAAMKDLKFALKAASLENADLAAILPAATVGSILVEIVKCVEKISEAVHELSQLAHFEKETVEPTVSPEKRPQLLHRGIIQPVLDGDSTANDNVVITIHEIISTDSPENEKACDQHQVPKPGKKIEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S483</accession>
    <name>A0A0D2S483_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S-protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G224400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the plant self-incompatibility (S1) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S483"/>
    <dbReference type="Gramene" id="KJB26085">
        <property type="protein sequence ID" value="KJB26085"/>
        <property type="gene ID" value="B456_004G224400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SQIK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIWIARD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060320">
        <property type="term" value="P:rejection of self pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010264">
        <property type="entry name" value="Self-incomp_S1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31232">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31232:SF60">
        <property type="entry name" value="S-PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05938">
        <property type="entry name" value="Self-incomp_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0713">Self-incompatibility</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB26085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="133" mass="15777" checksum="1C79BBEA8907884B" modified="2015-04-29" version="1" fragment="single">SEPIEGHDDNNNSNLSLRITWHVHTVNDLSDGKILLVHCKSKDDNLGIHNLTVGSEFSWKFKQQILGATLFWCYMAYYNFYASFDVFWVTEVFLHKCNYHDCIWIARDDEIYLKIFPDQHDEYTHSWESGRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SE64</accession>
    <name>A0A0D2SE64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G146700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SE64"/>
    <dbReference type="STRING" id="29730.A0A0D2SE64"/>
    <dbReference type="Gramene" id="KJB81457">
        <property type="protein sequence ID" value="KJB81457"/>
        <property type="gene ID" value="B456_013G146700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783213"/>
    <dbReference type="eggNOG" id="KOG1677">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.1190:FF:000004">
        <property type="entry name" value="Zinc finger CCCH domain-containing protein 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000033">
        <property type="entry name" value="zinc finger CCCH domain-containing protein 37"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050974">
        <property type="entry name" value="Plant_ZF_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506">
        <property type="entry name" value="PROTEIN PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506:SF82">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 64-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="102"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="272"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="6">
        <location>
            <begin position="413"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB81457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="459" mass="50303" checksum="19380AD162514EC7" modified="2015-04-29" version="1">MANQFYGYSSPSPSASTLHRYLDSDAASQSQSHLLQQLHPSAAAAAAAAASLIKRPSQVLYHQNVLDAQNTLGQIEAWYSASSLVKRPRLESASNLPIYPQRPGEKDCAHYMLTRTCKFGDSCKFDHPIWVPEGGIPYWKEVPPVPAGESLPERPGEPDCPYFLKTQRCKFGSKCKFNHPKDKLDAPGDSENLTVSGLPERPSEPPCAFYMKTGTCKFGSTCKFNHPKDIQIQLSLQNNVNCEQSDIAMKIGGISGDIKPALYHNSKGLPVRPDEVDCPFYLKTGSCKYGSTCRYNHPDRNAFVPPVALGHSLIASASNLNIGVVNPASSLYQTIDPRLSQTTLLAQQTMPTLVGTQPVYPQRPGQTECDYYMKTGECKFGDRCKFHHPIDRLTTNEASQQAIKLTLAGLPRREGSVHCPYYMKTGTCKYGATCKFDHPPPGEVMSVTGVQGTSTTMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SI18</accession>
    <name>A0A0D2SI18_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_007G110700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SI18"/>
    <dbReference type="STRING" id="29730.A0A0D2SI18"/>
    <dbReference type="Gramene" id="KJB41591">
        <property type="protein sequence ID" value="KJB41591"/>
        <property type="gene ID" value="B456_007G110700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB41592">
        <property type="protein sequence ID" value="KJB41592"/>
        <property type="gene ID" value="B456_007G110700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802821"/>
    <dbReference type="eggNOG" id="KOG0202">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="XLSENQS"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000021">
        <property type="entry name" value="calcium-transporting ATPase, endoplasmic reticulum-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000077">
        <property type="entry name" value="ECA1 (ER-TYPE CA2+-ATPASE 1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB41591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1050" mass="115977" checksum="89B19CD0E23E5AB0" modified="2015-04-29" version="1">MEERAFPAWSWSVEHCLKEYDVRLDKGLSSYKVEKQREKYGWNELAKEKGKPLWRLVLEQFDDMLVKILLVAAFISFLLAYMHGSESEESGFEAYVEPFVIVLILFLNAIVGVWQETNAEKALEALKEMQCESGKVLRDGFLVPDLPARELVPGDIVELQVGDKVPADMRIAALKTSTLRLEQSALTGEAMPVLKGTSPIFQKECELQAKENIVFAGTTVVNGCCVCIVVCTGMNTEIGKIQRQIHEASLEESDTPLKKKLDEFGSRLTTAIGIVCLIVWLINYKNFLSYDMVDGWPANFRFSFEKCTYYFKIAVALAVAAIPEGLPAVITTSLALGTRKMAQKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVAEFFTLGGKTTTSRIFHVKGTTYDPKDGGIVDWTCYNMDANLQVMAEICAVCNDAGIFCDGRLFRATGLPTEAALKVLAEKMGVPDAKMRNKIRDSELVANYLIDRSTVKLGCCEWWIKRSKRVATLEFDRVRKSSSIIVREAAGQNRLLAKGAVESLLERSTHVQLADGSLAPMDEPCRQLLLSRQTEMSSKGLRCLGLAYKEDLGEFSDYYSENHPAHKKLLDPACYCSIENDLVFVGVVGLRDPPRDEVHKAIEDCKGAGIRVMVITGDNKSTAEAICREIKLFSDGEDLRGKSFTGKEFMALSPSQQIETLSKPGGKVFSRAEPRHKQEIVRMLKEMGEIVAMTGDGVNDAPALKLADIGIAMGITGTEVAKEASDMVLADDNFSTIVSAVAEGRSIYNNMKAFIRYMISSNVGEVISIFLTAALGLPECMIPVQLLWVNLVTDGPPATALGFNPPDIGIMHKPPRRSDDALINSWVLFRYLIIGSYVGIATVGIFILWYTRASFMGINLVSDGHTLVELSQLHNWGECSTWSNFTVAPYMVGGGQLITFSNPCDYFTAGKVKAMTLSLSVLVAIEMFNSLNALSEDSSLLTLPPWRNPWLLVAMSVSFGLHCLILYVPFLADIFAVAPLSLNEWFLVILVSVPVILIDEILKFVGRSQRYRVKEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SIA4</accession>
    <name>A0A0D2SIA4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G440500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SIA4"/>
    <dbReference type="STRING" id="29730.A0A0D2SIA4"/>
    <dbReference type="Gramene" id="KJB62853">
        <property type="protein sequence ID" value="KJB62853"/>
        <property type="gene ID" value="B456_009G440500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768461"/>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTNKGQC"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF106">
        <property type="entry name" value="ANTHER-SPECIFIC PROLINE-RICH PROTEIN APG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267289" evidence="5">
        <location>
            <begin position="28"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB62853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="361" mass="39737" checksum="FED423358602D374" modified="2015-04-29" version="1">MVKMDGNNFIFFLTICVLSWRMELLKAQMVPAVYVFGDSLVDVGNNNFLPVSFAKANFPHNGVDFPTRKPTGRFCNGKNAADLLAEKLGLPSSPPYLSLSVNNITSHLTGASFASGGAGIFNSTDHVFGQAIPLSNQVDDFMSLNKILMKQGSSAAQNHTSKSLFAFVIGSNDLFDYFGSPNLRKQNTPQQYVDLMVTTLKQQLMRLYAVGARRFFLGGVGAIGCIPVERVKNKSHGCNAEHNFWAVKYNDGLKAMLNELKSKLRGFNYSFFDTYGIMQTITQNASTYGFNETEAACCGLGELRAIVPCLPFVTQCSNRTDHMFWDLYHPTEATTGIVVDTLFDGPSQYCVPINVRQLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SKP2</accession>
    <name>A0A0D2SKP2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G155500</name>
        <name evidence="5" type="ORF">Gorai_018818</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
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        <property type="entry name" value="OS01G0917900 PROTEIN"/>
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    </dbReference>
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        <location>
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            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0590099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="362" mass="39710" checksum="E5C9D8582A150EEA" modified="2015-04-29" version="1">MESSNRRLTLFEQMSAVDNGRTSLAAAFTLDALLGNTKPPQQPPSHNRTLLEIILDDGSNKDKKSWKAFRDKIRLKRPGSALTSSLHVPVSDVNVQTDRSQLPRRGPFLSDPDDSVRVEDGGERAPVSDPPVLNSLLRLERTDSDSDRFGHDPMQPFNDDSADVSMPSNAPPLRRVRPQTDRNDSNRLPSSNTAVNNIDSSEDDDSPLARHVTRQLGAVLAEERALSAREAAEAAAAAVEQAAVTVNNAPPASEEPVRMSLMELLEETSQQMGLMGSSYIISDAGEEYEKEEVTDEDEDEKEVVQSSGGMEHACCVCMVRHKGAAFIPCGHTFCRLCSRELWVQRGNCPLCNGSILEILDIF</sequence>
</entry>
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    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Gunneridae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
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        <text evidence="2">Belongs to the BRX family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="InterPro" id="IPR027988">
        <property type="entry name" value="BRX_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46058:SF3">
        <property type="entry name" value="PROTEIN BREVIS RADIX-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        </location>
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        </location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51514"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB65263.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="16 17">
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        <lineage>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
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    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Secreted</location>
            <location evidence="2 14">Extracellular space</location>
            <location evidence="2 14">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SRS2"/>
    <dbReference type="Gramene" id="KJB44741">
        <property type="protein sequence ID" value="KJB44741"/>
        <property type="gene ID" value="B456_007G269600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804570"/>
    <dbReference type="eggNOG" id="ENOG502QQ4A">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADMHSPM"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000005">
        <property type="entry name" value="Germin-like protein subfamily 1 member 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0052">Apoplast</keyword>
    <keyword evidence="8 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5019613155" description="Germin-like protein" evidence="14">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="15">
        <location>
            <begin position="63"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>oxalate</name>
            <dbReference type="ChEBI" id="CHEBI:30623"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601929-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB44741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="225" mass="24148" checksum="7178BC952CB12479" modified="2015-04-29" version="1">MKGVQFLVGFVLLALASKFVSASDASPLQDFCVAINDTIDGVFVNGKFCKDPKLATAEDFFLPGLNIPGNTSNQVGSMVTPANVQQIPGLNTLGISLVRIDYAPYGGLNPPHTHPRATEILLVVDGTLSVGFVTSNTDNRLFTKVLYPGDVFVFPEGMIHFQFNIGSTNAVAFAALSSQNPGVITIANAVFGSDPAINPDVLAKAFQLDQNIVKQLQSRFWWDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2STG6</accession>
    <name>A0A0D2STG6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G071900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2STG6"/>
    <dbReference type="STRING" id="29730.A0A0D2STG6"/>
    <dbReference type="Gramene" id="KJB34550">
        <property type="protein sequence ID" value="KJB34550"/>
        <property type="gene ID" value="B456_006G071900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DPPDHGE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000005">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF776">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="197"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB34550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="350" mass="39450" checksum="6FC0AD7101150AB7" modified="2015-04-29" version="1">MAASFTRDSGTQTPTTYDRFQELKAFDDSKSGVEDHDSVKPIPTQFTIPVIDLENIKTRSDEVVEGIRKAGGEVGFFQVVNHGVPRSVLEGMLAAARGFHELPTEVKKSYYTREKTKKIIYGSNFDLYELRFANWRDTLFCVMGPEPLHPQQLPLVCRDITMEYSKQIHKLGTTLFKLLSKAIGLTPDHLIGLDCSKGHCLLSHYYPACPEPELTLGTTKHSDPDFLTILLQDHIGGLQVFHQNQWFDVPFLPGALVVNIGSLLQLISNDKLISVEYQVLANEKGPRVSVACFFTPHLYPSTRIYGPIKELLSKENPPLYRETTVEDFISYYDSKGLDEKSALAHFKLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVN3</accession>
    <name>A0A0D2SVN3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Angiotensin-converting enzyme 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G353400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB46101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVN3"/>
    <dbReference type="STRING" id="29730.A0A0D2SVN3"/>
    <dbReference type="Gramene" id="KJB46101">
        <property type="protein sequence ID" value="KJB46101"/>
        <property type="gene ID" value="B456_007G353400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQTW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006476">
        <property type="entry name" value="CHP01589_pln"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01589">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871:SF1">
        <property type="entry name" value="HISTIDINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31871">
        <property type="entry name" value="OS02G0137100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09713">
        <property type="entry name" value="A_thal_3526"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB46101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="344" mass="38390" checksum="E78C79684FCE2CD7" modified="2015-04-29" version="1">MVHRTKSSLSGYPALYESAETRRMSTGDVKRVSRQDIQLVQNLIERCLQLYMTQKEVVETLLAQAKIEPGFTELVWQKLEEENREFFQAYYLRLMVKQQIVEFNKLLEQQVRLMSQIRSAGVSSISNSNGPQMPLMPQNSSCYAPENTGPALKQENMHHPMDSSLPNVFTNGSSALHAGIHPPIELASHASRIDAPQGMLSTQNSNMGLMQGMNGKMIKPEAGYSSGAPYMFGAESNVLEARPTIGDTSFSTVESSTQPLNEPLLDADISSFGFLGQIPRNFSLSDLTADFSQSSDILESYPRSPFLAPDNETFLDSREREHQGDNKRLDTISEGLSYDDFRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXX2</accession>
    <name>A0A0D2SXX2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G105600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXX2"/>
    <dbReference type="Gramene" id="KJB48979">
        <property type="protein sequence ID" value="KJB48979"/>
        <property type="gene ID" value="B456_008G105600"/>
    </dbReference>
    <dbReference type="OMA" id="MGPKNAS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251309" description="Secreted protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB48979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9045" checksum="628A9D54F52A0744" modified="2015-04-29" version="1">MGPKNASSPQIFSLLCGLLRLTILPSMIPLVQGKYLHYHHLPYDHRRWDKRVLCRLHHVQIGSAPSLDKKKRKLHLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SY07</accession>
    <name>A0A0D2SY07_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G237500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SY07"/>
    <dbReference type="STRING" id="29730.A0A0D2SY07"/>
    <dbReference type="Gramene" id="KJB68298">
        <property type="protein sequence ID" value="KJB68298"/>
        <property type="gene ID" value="B456_010G237500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB68299">
        <property type="protein sequence ID" value="KJB68299"/>
        <property type="gene ID" value="B456_010G237500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774585"/>
    <dbReference type="eggNOG" id="ENOG502QWBK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPFQHGR"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF18">
        <property type="entry name" value="HYDROLASE C777.06C ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="88"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="329" mass="37013" checksum="77F6FFBB5A6A25D9" modified="2015-04-29" version="1">MENQKPLQNGNNVAGDDRRRVGDGSALIFLGTGCSSAVPNAMCLIQPSDPPCHVCSQSLSIPPEHNPNYRCNTSLLIDYCSTNGMHNYIIIDVGKTFKEQVLRWFTFHKIPRIDSIVLTHEHADAVLGLDDIRVVQPHSPTNDIDPTAIYLTQYAMDSVAAKFPYLVQKKLREGQEVRRVAQLDWRIIEEDYDKPFVASGLKFVPLPVMHGEDYICLGFLFGEKSKVAYISDVSRFPSNTEYVISKSGSGQLDLLIVDCLYKKGSHNVHLCLPQTLDALKRICPKRALLIGMTHDFDQHKDNKVLMEWSEREGIHVQLARDGLKVPIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1Z9</accession>
    <name>A0A0D2T1Z9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Monocopper oxidase-like protein SKU5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_006G212500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1Z9"/>
    <dbReference type="Gramene" id="KJB37590">
        <property type="protein sequence ID" value="KJB37590"/>
        <property type="gene ID" value="B456_006G212500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000012">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000016">
        <property type="entry name" value="Monocopper oxidase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000023">
        <property type="entry name" value="Monocopper oxidase-like protein SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF123">
        <property type="entry name" value="MONOCOPPER OXIDASE-LIKE PROTEIN SKU5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252223" description="Monocopper oxidase-like protein SKU5" evidence="12">
        <location>
            <begin position="24"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="34"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="13">
        <location>
            <begin position="160"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="399"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB37590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="66714" checksum="409AB40CCAA44ABC" modified="2015-04-29" version="1">MALSRFWGWFLIHIALFLSLCYAEDPFVFYDFEVTYITASPLGVPQQVIAINNKFPGPTINSTTNNNVVINVRNKLDESLLMHWSGIQQRRSSWQDGVLGTNCPIPPKWNWTYQFQVKDQVGSFFYFPSLHFQRAAGGFGSFIINNRPIIPIPFDTPDGDIVILIGDWYTRNHTALRKALDAGKGLGMPDGVLINGKGPYRYNDTLVPDGIEYETINVHPGGKTYRLRVHNVGISTSLNFRIQSHNLLLAESEGSYTVQQNYTSLDIHVGQSYSFLLTTDQNASSDYYIVASARFVNESQWKRVTGVAILRYSNSKGKASGPLPDPPQDDFDKTFSMNQARSIRWNVSASGARPNPQGSFRYGSINVTEVYVLRNKPPETIDGKRRATLSGISFVNPATPIRLADQYKIKGVYKLDFPNKPLTGPPKMETSVINGTYRGFMEVILQNNDTKMHTYHMSGYAFFVVGMDYGEWSENSRGTYNKWDGIARSTTQVYPGAWTAILISLDNVGVWNLRTENLDSWYLGQETYVRVVNPEATNKTELPMPDNALFCGALSKLQKPQDVSSSLATSIIEGRSKLFFTVLMIASTLFLVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T9M8</accession>
    <name>A0A0D2T9M8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G177500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T9M8"/>
    <dbReference type="STRING" id="29730.A0A0D2T9M8"/>
    <dbReference type="Gramene" id="KJB72423">
        <property type="protein sequence ID" value="KJB72423"/>
        <property type="gene ID" value="B456_011G177500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3196">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNEVTKD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371:SF3">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10371">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE FLAVOPROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB72423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="97" mass="10660" checksum="62F53A130FE1C0FF" modified="2015-04-29" version="1">MWSLVCGTTSCMICGSGEIEGALLKYLGVEHNEVTKDGLFSVGEMECMGCCVNAPMIAVADYTNEYEGYTYNYYVDVTTQRVVEIVEIVAVGFCQEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TDL4</accession>
    <name>A0A0D2TDL4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G269900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TDL4"/>
    <dbReference type="STRING" id="29730.A0A0D2TDL4"/>
    <dbReference type="Gramene" id="KJB52597">
        <property type="protein sequence ID" value="KJB52597"/>
        <property type="gene ID" value="B456_008G269900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB52601">
        <property type="protein sequence ID" value="KJB52601"/>
        <property type="gene ID" value="B456_008G269900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB52602">
        <property type="protein sequence ID" value="KJB52602"/>
        <property type="gene ID" value="B456_008G269900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765461"/>
    <dbReference type="eggNOG" id="KOG1562">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000003">
        <property type="entry name" value="Spermidine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000048">
        <property type="entry name" value="Spermidine synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF25">
        <property type="entry name" value="SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="7">
        <location>
            <begin position="53"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB52601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="356" mass="39218" checksum="1EEF593B39DAD4A3" modified="2015-04-29" version="1">MGEDAGKGLECPKLMDGKGNSGNGSEKVIPSCCLKARASAPELEAKCHSTVVSGWFSESQSSSDDAGKMVYFNNPMWPGEAHSLKVESILFKEKSDYQEVLVFESSTYGKVLVLDGIVQLTEKDECAYQEMIAHLPLCSIPSPKTVLVVGGGDGGVLREISRHSSVEHIDICEIDKMVIDVSKKFFPELAVGFEDPRVDLHVGDAIEFLRHAPKGKYDAIIVDSSDPVGPAQELVEKPFFETLAQALRPGGVLCNMAESMWLHTHLIEDMISICRETFKGPVHYAWASVPTYPSGVIGFLLCSTEGPPVDFLNPINPIEKLDGAYLHKRELRFYNSEMHRAAFALPSFLKREVRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TF14</accession>
    <name>A0A0D2TF14_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G288600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TF14"/>
    <dbReference type="STRING" id="29730.A0A0D2TF14"/>
    <dbReference type="Gramene" id="KJB74333">
        <property type="protein sequence ID" value="KJB74333"/>
        <property type="gene ID" value="B456_011G288600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776876"/>
    <dbReference type="eggNOG" id="KOG0667">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14133">
        <property type="entry name" value="PKc_DYRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000216">
        <property type="entry name" value="Putative serine/threonine-protein kinase dyrk2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF113">
        <property type="entry name" value="HYPOTHETICAL SER-THR PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="394"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB74333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="700" mass="80316" checksum="FC2BA01C8C5132A8" modified="2015-04-29" version="1">MEVSFDVEAVMEFLRKNGLKEAEKALQQDMIEKNEDGEKMGAFDFEKFLFPMPPPVRIPATTRRSEEDEKEKSGDGWGSDGDEFVSLRSSSSDVCSSEFVNPYGLNSASQANSDTSSDRLSQFGTARDYPDFEMQNDLFWHEEKDEDDFMTPCFAGSDFYGCPSQDKFVTTLEMEKQRDNTRSSYDKSEGFGTEDGLDYLDKPCLFNMTGIDGESDIRVMDYYCFDKCNGLEGDNDIVPELKDCAYDENLLNFGCIGSKGTNFDDFEVKVAGDVITDYNGTSECISKTNHYTAKRGSNDWIEGFIGDSDLVNKISEKSLSPDTIDTNEVEDGELNEPQVATNEEGDATDELLMYSNEDEYEEFNLRIVHRKNRTGFEENKDLPIVLNSVIAGRYYVTEYLGSAAFSKVVQAHDLLTGIDVCLKIIKNDKDFFDQSLDEIKLLKLVNKHDPGDEYHILRLYDYFYHQEHLFIVCELLRANLYEFQKFNQESGGEAYFTISRLQVITRQCLEALDYLHELGIIHCDLKPENILIKSYRRCEIKIIDLGSSCFRTDNLCLYVQSRSYRAPEVILGLPYDQKIDLWSLGCILAELCSGEVLFPNDAVVMILARMVGMLGPIDMEMLENGQETYKYFTKDYDLYHINEETDQLEYIISEESSLEHHLQVSDVLFVDFVRHLLEMNPRRRPNAREALKHPWLSHSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TGA6</accession>
    <name>A0A0D2TGA6_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G008600</name>
        <name evidence="2" type="ORF">Gorai_003912</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0600712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TGA6"/>
    <dbReference type="STRING" id="29730.A0A0D2TGA6"/>
    <dbReference type="Gramene" id="KJB74803">
        <property type="protein sequence ID" value="KJB74803"/>
        <property type="gene ID" value="B456_012G008600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780527"/>
    <dbReference type="eggNOG" id="ENOG502S071">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VPWVPSH"/>
    <dbReference type="OrthoDB" id="1937743at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35510">
        <property type="entry name" value="DBH-LIKE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35510:SF1">
        <property type="entry name" value="DBH-LIKE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB74803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0600712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="202" mass="22581" checksum="08A17616C3805937" modified="2015-04-29" version="1">MGLIGKLKRKEIDQVNDDFSDFSLSSPATKIRRLDADLPPIIEEDSLPENHEKAIVLFNPNPLLLHDTPPLSSPPSTLSFSFDSHLLSGFKNQILRAADMKSAETEESKMENEGCLAVVPWVPSQIASVETRDSEQQVPALMETDEMDVEESCSNSGSMQEEHGYELDGLKPRDALHNWAQQQHCMLPQPPQNPFTPITWSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TKR5</accession>
    <name>A0A0D2TKR5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G067700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TKR5"/>
    <dbReference type="STRING" id="29730.A0A0D2TKR5"/>
    <dbReference type="Gramene" id="KJB55181">
        <property type="protein sequence ID" value="KJB55181"/>
        <property type="gene ID" value="B456_009G067700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S64D">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSDQHET"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012417">
        <property type="entry name" value="CaM-bd_dom_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33349:SF20">
        <property type="entry name" value="CHROMO DOMAIN CEC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33349">
        <property type="entry name" value="EMB|CAB62594.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07839">
        <property type="entry name" value="CaM_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calmodulin-binding" evidence="2">
        <location>
            <begin position="385"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB55181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="504" mass="55272" checksum="D2FAC156AD1C6AE9" modified="2015-04-29" version="1">MATTRRETSTPVKEKRGTSPLNSKPSPRKATSSSSTASDSTEKQLPNYLKPTKSSRTDAALKNLKKPGADDPSQCPSVMRRRSFDRPPSAARAHKALISPVRQKSASTSTSPSFSSKSATAPKAPLERVAKKAIAAAKPHTQTLSSSRRAPTTTTSATTRTSRSKRGASTPPPTSMKPPSSPDRKEAQSPETKHENKENLDHQVEPEEVVKDDEDEMYDINLPKAEETANADALDVDTTTQVTSDADEGGQDTVDFPNAVSQEHNETETEPEPEPRNNVEEGKPDHTQHDCGDKENHSQEEIIAGADPQQEKTPLEDQKVKTETEHGEENATNEVVADTKETEEEQEEKQPESRQKDADEGNLPQGLESIKEKMVKGLDAEPEKEQKAEIEEEPEADQKAETEAQQKTETEVEQKTDTEAEQKTETETEKKTEPKAEAEQKAGTEVANVAAKSQVQGKKEPAKPYNDVIEETASKLVAEKRRNKVRALVGAFENVIDKETTNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TL28</accession>
    <name>A0A0D2TL28_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">pyruvate decarboxylase</fullName>
            <ecNumber evidence="6">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_009G164100</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="6"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TL28"/>
    <dbReference type="STRING" id="29730.A0A0D2TL28"/>
    <dbReference type="Gramene" id="KJB57434">
        <property type="protein sequence ID" value="KJB57434"/>
        <property type="gene ID" value="B456_009G164100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769239"/>
    <dbReference type="eggNOG" id="KOG1184">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036293">
        <property type="term" value="P:response to decreased oxygen levels"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1220:FF:000009">
        <property type="entry name" value="Pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000017">
        <property type="entry name" value="pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000021">
        <property type="entry name" value="Pyruvate decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF1">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE C186.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <keyword evidence="11 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="19">
        <location>
            <begin position="28"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="17">
        <location>
            <begin position="225"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="18">
        <location>
            <begin position="435"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB57434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="589" mass="63435" checksum="C41B17E8349C0CFB" modified="2015-04-29" version="1">MEAGHKIGSSAHPTSLHPPVRGDASSGTLGRHLARRLVEIGVKDVFSVPGDFNLTLLDHLIAEPELNLVGCCNELNAGYAADGYARAKGVGACVVTFTVGGLSVLNAIAGAYSENLPVICIVGGPNSNDYGTNRILHHTIGLPDFSQELRCFQTITCAQAVVNNLDDAHELLDTAISTALKESKPVYISIGCNLPGIPHPTFARDPVPFFLAPKVSNQLGLEAAVEATANFLNKAVKPVLVGGPKLRVANAKDAFVELADACGYPIAVMPSGKGLVPEHHPHFIGTYWGAVSTSFCGEIVESADAYVFAGPIFNDYSSVGYSLLIKKDKAIIVQPNRVTIGNGPSFGWVFMADFLSALARKLKKNTTAVENYQRIFVPPGMPLKHGNDEPLRVNVLFKHIQDMLSKDSAVIAETGDSWFNCQKLHLPENCGYEFQMQYGSIGWSVGATLGYAQAAKDKRVIACIGDGSFQVTAQDISTMIRCGQKSIIFLINNGGYTIEVEIHDGPYNVIKNWNYTAFVDAIHNGEGKCWTAKVRTEDELIDAIAAATGEKKDSLCFIEVFAHKDDTSKELLEWGSRVSSANSRPPNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TM83</accession>
    <name>A0A0D2TM83_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cardiomyopathy-associated protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G093400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TM83"/>
    <dbReference type="Gramene" id="KJB55771">
        <property type="protein sequence ID" value="KJB55771"/>
        <property type="gene ID" value="B456_009G093400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QZQ3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSDEMWG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33870:SF32">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33870">
        <property type="entry name" value="CARDIOMYOPATHY-ASSOCIATED PROTEIN"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
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        <location>
            <begin position="83"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="939"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="452"/>
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            <begin position="939"/>
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            <begin position="1197"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB55771.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1228" mass="135348" checksum="441445083EF0B2F2" modified="2015-04-29" version="1">MSFNVKVIQNFVWKIIRFSGSCSYKFVRRYPVVAGFFIFVLFVYVCFPSYFYILMYSSPIFICTAISIRFYWKTKRPEVQMVHKKDSEERSSADVNRSKVPSLRPQKSVRRNARKEVLQWDRNDSPDSNLLFGSGINDILSDKSNLLEENSRSLNVKGSSNVEHGESSSQNEKRNDQALNDPKSLLDNETLKPHSVSGDSFGGQSGKSPVGGGGGGGEVEKERLEKRKDVKEIKVREDRDKAVEWTKDDEKHLMDLGLTEAERNKRLESLIAKRRARKMFKMAIEKSLMDKGIVPHNHIAPILIVKNNILGCSNHANEEVLQMPGSAPSILLPTQNPFDLPYDPFEEKPNLTGDSFQQEFMAVNQRDMLFCRHESFHHGPLFTFETTQDSINDPFNPYYSAEKRLVGGPAVDRFRKADDEGGHHQNNSRGFGSDIDLIELEESINNDTINSLEEKSEEITESANDKTEIGETNENPHDLSGSEMRVEIDSTKNNDSCYSASSSDDSESGLDQTAKPLSLCTNQVRKAFNLSIPPKGKAVTKLPFDSSPSPRRTEFNLFYNTYRRQSHTRNCSIASDLQVEVSEVGSTTLSTDGTSSPVEGSVTYDGDVERDINSDNEELWGGSFNLSKEANQEKLRELDDIIEEDSVEVKVSGLNKKPEEPIASISPSELEKASNVSDKLSPENPGKPVQLRGKSVIHSPSESCFQKPEQFIDPQQKPTEENIICNVKPITQGDANSLEPKSSETKANGAQALNEPAALGEMGKPDDAINLDSSGYKHGNKETSYEYKRTVESEKKMEENQPSKYIEEDAQNLIEYNTGNAPNAVQSIDELESIPASGVNQNILEDNVSGVEQRLGGSIAVAPNRRLELEQTYLSSGASPRSVLPQNILADQIPVSDIEQRRQTDWPGSVTEDIVRENSADNQPHENSTFNMPRSTQRLAENSIQDSSSNSGPATSEESSCVTKKRTDGSTAHNMNELVLEGTQGNDGSLKSSKDESKTLTSSEDTEELSKTSGESNFDSIEHLGGSEKLIEHNTRTDSSKSKEGNAKTDDPKTMVREKSAAEVDRVCNVKDSLTNKVTNIESSNPVLDGEGQHQILSRQKAVVEPSKTSGATSAGSDKDTKHESATLTKAEANAGLSTSKGESNSSNNIKNGGDTQKLSGQERLSDASQSREENLNKAISESISGVDSTATTGISIDHKIATEASKPKEPEVKAVNTKENDSNEVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TP45</accession>
    <name>A0A0D2TP45_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G219800</name>
        <name evidence="3" type="ORF">Gorai_012443</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TP45"/>
    <dbReference type="STRING" id="29730.A0A0D2TP45"/>
    <dbReference type="Gramene" id="KJB58634">
        <property type="protein sequence ID" value="KJB58634"/>
        <property type="gene ID" value="B456_009G219800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769539"/>
    <dbReference type="eggNOG" id="ENOG502QV69">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHPQFHR"/>
    <dbReference type="OrthoDB" id="1703411at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000085">
        <property type="entry name" value="F-box domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000169">
        <property type="entry name" value="F-box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006527">
        <property type="entry name" value="F-box-assoc_dom_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050796">
        <property type="entry name" value="SCF_F-box_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672">
        <property type="entry name" value="BNACNNG10540D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31672:SF12">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07734">
        <property type="entry name" value="FBA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="15"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB58634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0595577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="367" mass="42274" checksum="6E9E3C34E57D556D" modified="2015-04-29" version="1">MIAKSLKGRSAAMDPGIWSKLPPELLELILSFLPLKTLLNLRSTCKHFKSLVFSPSFISKYSSASLFSSFFLLSHPQCYSNFPLYDTTRGAWRKLALPLSFLPPSAAQFNLLSSCNGLFCFSLPNSSSFLVCNLLAKSSRPIQFPFFPFAFEMLTLVSTPHGYKIFLLCSKFSSNYAFVYDSKVHSWRQFDGFQPLLADNFHQEGASFNGSLYFATPEPFSVVCFDLENGKWENLDTEMPRELTFVRLVSNTDEGKLYMVGGIGRNGISRSMKLWEMGDGGNWVEVERLPELMCRKFMSVCYHNYEHLYCFWHQDMICVCCHTWPEILYCKVSRRTWHWIPKCPSIPDKWSCGFRWFSFVPDLYTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQK7</accession>
    <name>A0A0D2TQK7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_007G327500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQK7"/>
    <dbReference type="STRING" id="29730.A0A0D2TQK7"/>
    <dbReference type="Gramene" id="KJB45780">
        <property type="protein sequence ID" value="KJB45780"/>
        <property type="gene ID" value="B456_007G327500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4731">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LTHIRCK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09631">
        <property type="entry name" value="DOMON_DOH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057443">
        <property type="entry name" value="At5g54830-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045879">
        <property type="entry name" value="B561A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019545">
        <property type="entry name" value="DM13_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045266">
        <property type="entry name" value="DOH_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47281:SF1">
        <property type="entry name" value="OS09G0557700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25489">
        <property type="entry name" value="At5g54830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03351">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00686">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51549">
        <property type="entry name" value="DM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252181" description="DOMON domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="595"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="627"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="DM13" evidence="10">
        <location>
            <begin position="36"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="9">
        <location>
            <begin position="439"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB45780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="750" mass="84129" checksum="F3B769D2B13F91B1" modified="2015-04-29" version="1">MYNSKIFLLIPLFLINSIASSKADSGQKCSNISSLVGFESNFTMVRHQLRGHLKILNGYSFQVTGFDMLSGSSDVIFWGAVSFNFSDLTSGFPISVQLLPDITWDQINILSIWDIASTSDFGHVTLPRNGSDSVSGSMHTVFDNCKNLSDNYRVRWNLNDEGVDVTVASFTEEGRPFVDDFYITAYSECKLSSKDRTAIGVCPDVVYENSKNGMMVNNTRLVYGHRRDGVSLIMFRKPLNSTDKKLHFSHLCLKCYVLVTYVIVLLRSGPFTIELHYLPNGSPTWQFKWVLNANLDKYDLPVYPNEDMRVIWALGLMKPPKENRSHFLPQFHGDPEKKLERGVPVKFLAQAGHAVALYITSDSLGGNATLRNATETIYSGGPEAEGVVANPHELIWVPDRNTPDQVYYQSLYQEKMGWKVQVFDGALSDMYNTSVLLDDQVTFFWTSSEDSITIAARGVNKSGYLAIGFGNGMVNSYAYVGWIGDSGKGHLNTYWIDGKHPLNIHPTNENLTHVRCRSEDGIITLEFTRPLKPSCNQNDKPQCKNIVDPTTPLKVIWAMENMHTVTSQRPVQVLLIRGSSNAEQGLQPVKAVHGFMLFLSWGILIPGGILAARYLKHVKGDGWYQIHIYLQYSGLAIILLGVLFEVAELRGFYVSSLHVKLDRTKPANGEDASTKRLIWEYFHVIIGRGAIAVGIAALFTGMKHLGEKYRVENVHDLSWVLIIWFLIAALTCKSDSMERFNLNTSSQVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQR8</accession>
    <name>A0A0D2TQR8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thaumatin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G243400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thaumatin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQR8"/>
    <dbReference type="Gramene" id="KJB59189">
        <property type="protein sequence ID" value="KJB59189"/>
        <property type="gene ID" value="B456_009G243400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765946"/>
    <dbReference type="eggNOG" id="ENOG502QVGZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHNCPSE"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="CDD" id="cd09218">
        <property type="entry name" value="TLP-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.110.10:FF:000002">
        <property type="entry name" value="Thaumatin-like protein 1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017949">
        <property type="entry name" value="Thaumatin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00316">
        <property type="entry name" value="THAUMATIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251969" description="Thaumatin-like protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="33"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="93"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="143"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="148"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB59189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="30683" checksum="52961C42632D1F53" modified="2015-04-29" version="1">MDQLLPLLFILLMLSSGAKVYECARTFTIINNCKDTIWPGIIPGESFNGGGLELKSHQSIVFDAPVGWSGRIWGRTGCKFDDNGNGPCQTGDCGQTLKCGVAGKTPVSLAEFTLATLDFYDVSLVDGFNLPLSVTPINGKGNCSTAGCNSDVRHNCPSELAVKAKGKVIACRSACDVFDTDEYCCRGTYGNPSTCRPTYYSNIFKSACPTSYSYAYDDPTSIFTCSGADYVITFCSTRNQPVCTYHDHKLVCKNKANGLNPSVGRWWATLLAPLLMANLRFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TSA9</accession>
    <name>A0A0D2TSA9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G3613001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="B456_007G3613001"/>
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        <property type="component" value="Chromosome 7"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rx_N"/>
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        <property type="entry name" value="DISEASE RESISTANCE RPP13-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB46340.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30550" checksum="922DACB662CA0B5C" modified="2015-04-29" version="1" fragment="single">MSVIGEAALSGFLDLLVGKSLDSALNFVADHKQLHQQLKQWQSILPDIQAVLDDAEEKQIKNMGVKKWLEDLQDLAYDVDDILDEFAYEELKPALARSSLGLSEILSQAPTSKGKQPRLQPTSVLDGVVEYVGRHKEKTEMIEFLKGDNSNGVSVLSIVGMGGMGKTTLAQLVYNDATINQSFHHKAWVCVSDNFDAVNITRTILKSIDPDSRDENDLNLLQVKLKEKLSGKRFLLVLDDIWNENYNDWTILRSPFGAGTHIIVTTRLQIVSSI</sequence>
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        <name type="scientific">Gossypium raimondii</name>
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    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
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    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Responsible for the cyclization of trans,trans-farnesyl diphosphate (FPP) to (+)-delta cadinene.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.13" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U0W9"/>
    <dbReference type="STRING" id="29730.A0A0D2U0W9"/>
    <dbReference type="Gramene" id="KJB62654">
        <property type="protein sequence ID" value="KJB62654"/>
        <property type="gene ID" value="B456_009G427900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768276"/>
    <dbReference type="eggNOG" id="ENOG502QUCN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TTAINRW"/>
    <dbReference type="OrthoDB" id="1877784at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047461">
        <property type="term" value="F:(+)-delta-cadinene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016102">
        <property type="term" value="P:diterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00684">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000007">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.130:FF:000001">
        <property type="entry name" value="Isoprene synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.130">
        <property type="entry name" value="Terpene synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034741">
        <property type="entry name" value="Terpene_cyclase-like_1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044814">
        <property type="entry name" value="Terpene_cyclase_plant_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001906">
        <property type="entry name" value="Terpene_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036965">
        <property type="entry name" value="Terpene_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF215">
        <property type="entry name" value="(+)-DELTA-CADINENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01397">
        <property type="entry name" value="Terpene_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01019">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01604">
        <property type="entry name" value="Terpene_Cyclase_Like_1_C_Termi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="11">
        <location>
            <begin position="258"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB62654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="554" mass="64966" checksum="2470B7F347224DFA" modified="2015-04-29" version="1">MASQVSQMPSSSPLSSHKDEMRPKADFPPSIWRDFFHNCPDKNIDAETEKRHQQLKEEVRKMIVAPMANSTQKLTFIDSVQRLGVSYHFTKEIEDELVNIYHNNNDAENDLYTTSLRFRILREHGFHVSCSAFNKFNDEQGNFKSSVTNDVRGLLELYEASYLRVHGEDILDEAISFSANHLSLAVASLDYPLSEQVSHALKQSIRRGLPRVEARHYLSVYQDIESHNKALLEFAKIDFNMLQLLHRKELSEICRWWKDLDFQRKLPYTRDRVVECYFWILGVYFEPQYSLGRKMMTKVIIMTSVIDDTYDSYATYDELIPYTSAIERWEIKCIDQLPEYMKLSYKALLDVYEEMKQLVVEHGRQYRVEYAKNAMIRLSQSYFVEAKWTLQNYKPSFEEFKINALSSSGYAMLAITSFVGMGDIVTPETFKWAANEPKIIQASTIICRFTDDIAEHKFEHRREDDWSVIDYYMKEYNVTAQEAYDVFNKYIESAWKDTNQELLKPTEMPTEVMNRSLNLSRVMDVVYKEGDGYTYVRKAMKDVITSLLIEPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U1I1</accession>
    <name>A0A0D2U1I1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome b561 and DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G441600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 2 heme b groups non-covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U1I1"/>
    <dbReference type="STRING" id="29730.A0A0D2U1I1"/>
    <dbReference type="Gramene" id="KJB62859">
        <property type="protein sequence ID" value="KJB62859"/>
        <property type="gene ID" value="B456_009G441600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYRKYWN"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045265">
        <property type="entry name" value="AIR12_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017214">
        <property type="entry name" value="UCP037471"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF175">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04526">
        <property type="entry name" value="DUF568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037471">
        <property type="entry name" value="UCP037471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252240" description="Cytochrome b561 and DOMON domain-containing protein" evidence="12">
        <location>
            <begin position="25"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="13">
        <location>
            <begin position="59"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="14">
        <location>
            <begin position="191"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037471-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="431" mass="49002" checksum="4DC3C0947B663965" modified="2015-04-29" version="1">MQSFALDTIFILISLSSLSIVVSSSKPLNPCNGDFLHIQAYKQMQNQTNTTQCKKLSSLQAQFAWNYHKTSHNQTQLNILIGTKLIASTGWLAWGINPDLPRMVGTRAIIAVKVPNQITPSVNTYNITKDIQLGCKLQPSGIDFKVQNMTVVDDKDVGFFSVFATLVLPQRYNVSSLNHVWQVGYCVDGLEPKMHEASLGNLDSKEVLDLETGDCQNIGQHRRHMRKVHGILNIIGWGTLLPIGVIVARYFKQFPIKLDPCWYYFHYSCQVVGYILGTAGWGLGLFLGHESKYYTFHSHRVLGICIFGFTTLQILAFQFKPTQEDEYRKHWNVYHHFLGYALLVMIPVNIYKGIKLLKPDNITWKWTYNGILVLLGVVVLAFEILTWAVFLYKKCCKKTVEESSPRRVEIEEDSKGQTNEGSSPRKTEVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2H5</accession>
    <name>A0A0D2U2H5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G401800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2H5"/>
    <dbReference type="STRING" id="29730.A0A0D2U2H5"/>
    <dbReference type="Gramene" id="KJB62121">
        <property type="protein sequence ID" value="KJB62121"/>
        <property type="gene ID" value="B456_009G401800"/>
    </dbReference>
    <dbReference type="OMA" id="EFFLFKF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009658">
        <property type="term" value="P:chloroplast organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010027">
        <property type="term" value="P:thylakoid membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040299">
        <property type="entry name" value="RF2K-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34938">
        <property type="entry name" value="PROTEIN FERTILITY RESTORER RF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34938:SF1">
        <property type="entry name" value="PROTEIN FERTILITY RESTORER RF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="11443" checksum="EA601ECDB5EC5CFC" modified="2015-04-29" version="1">MATVVGAASNPLSNPIVSMVDGVSSRAFDEVLKATPPALSAFLAGLPSIEAKEKSPQLDDGDSGFPPRGGGGGGGNWSGEFFLFEFLAFLGFLKDKESEEDYRDSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U358</accession>
    <name>A0A0D2U358_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G145700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U358"/>
    <dbReference type="STRING" id="29730.A0A0D2U358"/>
    <dbReference type="Gramene" id="KJB49915">
        <property type="protein sequence ID" value="KJB49915"/>
        <property type="gene ID" value="B456_008G145700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB49916">
        <property type="protein sequence ID" value="KJB49916"/>
        <property type="gene ID" value="B456_008G145700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764121"/>
    <dbReference type="eggNOG" id="ENOG502QQHB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MCACSSA"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd23127">
        <property type="entry name" value="RING-HC_BAH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14482">
        <property type="entry name" value="SPX_BAH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033326">
        <property type="entry name" value="BAH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BAH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46764:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="11">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB49915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="324" mass="37083" checksum="24D5CAF4D37361CD" modified="2015-04-29" version="1">MKFCKKYQEYMQGQEKKLPGVGFKKLKKILKNCRREFQSKNDVHGVLHNQTCPQHCPVCDGTFFPSLLKEMSDIVGCFNERAQKLLELHLASGFRKYFIWFKGKLQGSHVTLIQEGKDLVNYALINAVAIRKILKKYDKVHFSKQGQAFKSQAQSMHIEILQSPWLCELMAFHINLRETKVKSGMTPASFEGCYLTFNDGKPFLSCELFDSVKLDIDLTCSICLDTVFDPVSLTCGHIFCYMCACSAASVSIVNGLKAAEPKEKCPLCREAGVYEGFVHLDELSILLRRSCSEYWEQRLQMERAERVRQAKEHWESQCQAFVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3E3</accession>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3E3"/>
    <dbReference type="Gramene" id="KJB82233">
        <property type="protein sequence ID" value="KJB82233"/>
        <property type="gene ID" value="B456_013G183400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:128031889"/>
    <dbReference type="OrthoDB" id="975065at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB82233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="173" mass="18905" checksum="B112E37FA54987AB" modified="2015-04-29" version="1">MGKNKPSLDACSLQPSADSNNVYTLVTNTKSRENHRLPVPDDSILSLLAIFIDESTRDGPEPEDAHSVLYFKASDLLDGHGHGHGHGVSLDDQSDEITSRLATSIDYSDVASPTTLKEIPQLSHDDSILAMLDIFTEDSTKLIVGEKREDGPLLVSLGDEKDDEIFSLLQNFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3P1</accession>
    <name>A0A0D2U3P1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G152500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U3P1"/>
    <dbReference type="Gramene" id="KJB50075">
        <property type="protein sequence ID" value="KJB50075"/>
        <property type="gene ID" value="B456_008G152500"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034565">
        <property type="entry name" value="Put_cell_wall"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36733">
        <property type="entry name" value="CELL WALL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36733:SF1">
        <property type="entry name" value="CELL WALL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252310" description="Cell wall protein" evidence="2">
        <location>
            <begin position="29"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB50075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10571" checksum="04BAEFE224026ABD" modified="2015-04-29" version="1">MACKISSLLLAHVFILSILFAIAGQAIAARLGRVLLPPVFKHHNSHTIGTGTHIGSSGGHFGSTIGGNRQIPGSGDDTFVPNPGFEVPIPAGRGAGIAGTNPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U474</accession>
    <name>A0A0D2U474_GOSRA</name>
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        <recommendedName>
            <fullName evidence="16">Allene oxide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_010G013700</name>
        <name evidence="13" type="ORF">Gorai_006926</name>
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    <organism evidence="12 14">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U474"/>
    <dbReference type="STRING" id="29730.A0A0D2U474"/>
    <dbReference type="Gramene" id="KJB63739">
        <property type="protein sequence ID" value="KJB63739"/>
        <property type="gene ID" value="B456_010G013700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774726"/>
    <dbReference type="eggNOG" id="ENOG502QQNS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQWLAPQ"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009941">
        <property type="term" value="C:chloroplast envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009535">
        <property type="term" value="C:chloroplast thylakoid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009695">
        <property type="term" value="P:jasmonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11071">
        <property type="entry name" value="CYP74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000024">
        <property type="entry name" value="Allene oxide synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF255">
        <property type="entry name" value="ALLENE OXIDE SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB63739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0597111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56058" checksum="6CFFDAC16049EBB3" modified="2015-04-29" version="1">MASSATLSSRRANVRSRLSVTVSELEKPELPLKSIPGDYGLPFIGAIKDRLDYFYNQGRDEFFKFKIQKYQSTVLRTNMPPGPFISSNPKVVALLDGKSFPILFDISKVEKKDLFTGTYMSSTYLTGGYRILSYLDPSEPKHAKLKQLLFFLLKSSRDRVLPEFKACYTELFKTVEYELAEKGKCSFQTPSEQAAFNFLARAFFDSNPVDSKLGSDGPSLANKWVLFQLGPIFTLGVPKYIEDLLLHTFPLPSFLVKKDYKKLYDFFYESAGLVLDEAEKMGISRDEACHNLVFATCFNSFGGIKVFFPIMLKWIGLAGENLHLSLAKEIRSVIKSNGGELSLSAMEQMPLMKSVVYESFRIDPPVQFQYGKAKKDLLIGSHHAVYEVKEGEMLFGYQPFATKDPNIFDRAEEFVPDRFMGVDEEKLLKYVLWSNGPETEHPTVADKQCAGKDFVMLVSRLFVVEFFRRYDTFEVEVGPAPVGVAVTITSLKAASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAQ7</accession>
    <name>A0A0D2UAQ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein Ycf2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_010G075500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Probable ATPase of unknown function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Ycf2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAQ7"/>
    <dbReference type="STRING" id="29730.A0A0D2UAQ7"/>
    <dbReference type="Gramene" id="KJB65001">
        <property type="protein sequence ID" value="KJB65001"/>
        <property type="gene ID" value="B456_010G075500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502STJG">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YLAGSFW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009536">
        <property type="term" value="C:plastid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33078:SF100">
        <property type="entry name" value="PROTEIN YCF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33078">
        <property type="entry name" value="PROTEIN YCF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB65001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="153" mass="17746" checksum="1DE3870BADBBE96E" modified="2015-04-29" version="1" fragment="single">ITSYGFVENDSDLVHGLLEVEGALVGSSRTEKDCGQFDNDRVTLLLRSEPGNPLYMIQNGSCSIVDKRNLYEKYKLEFEEGEGEGVLDPQQIEEDLFNHIVWAPRIWRPWGFLFDCIERPNELGFPYWVGSFRSKQIIYDEKNELQENDSTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UC86</accession>
    <name>A0A0D2UC86_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G298400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB53245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UC86"/>
    <dbReference type="Gramene" id="KJB53245">
        <property type="protein sequence ID" value="KJB53245"/>
        <property type="gene ID" value="B456_008G298400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S6TT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WHNAQTK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38525">
        <property type="entry name" value="OS03G0824500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS03G0824500 PROTEIN"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB53245.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_010G144500"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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        <location>
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        <location>
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        <location>
            <begin position="245"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB66579.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="321" mass="35931" checksum="DAAFFDB08AE05D10" modified="2015-04-29" version="1">MHFPWKKAKVTRISRLVAGLHQSPKRGGSLVVETGFPTSLIDLFVKNRDRLRKSSKKKSGPQILIPSPPCNEELQSHDMDDGELVIITREGDGEKIGLHLVFKISLMVALAVSTRNLAVWIMMAALLLVVIEFVGTHFLGFSRPQSKTLFFDSWIRKGLKSRADQLVEKQQGTDFPDPCEVIELKDEIRRETAIITCKSERSRSARFKTSLIKKFVPKKLRHEKSKKQGKSNKKKDKESSNQVANEEDESETEGGDQVLQVESEPENVRKRNSGTGYVVLLVMVILAGLLGGRGVALLLSVVCCLILIYIGTHQKTKMTLV</sequence>
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        <lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="entry name" value="PKC_DAG/PE"/>
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        <property type="entry name" value="Vacuole_Formation_Reg"/>
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    </dbReference>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHP2</accession>
    <name>A0A0D2UHP2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_010G233000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHP2"/>
    <dbReference type="Gramene" id="KJB68219">
        <property type="protein sequence ID" value="KJB68219"/>
        <property type="gene ID" value="B456_010G233000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772163"/>
    <dbReference type="eggNOG" id="ENOG502QTJX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MTTECIF"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000008">
        <property type="entry name" value="Tryptamine hydroxycinnamoyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF196">
        <property type="entry name" value="SHIKIMATE O-HYDROXYCINNAMOYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB68219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="214" mass="23803" checksum="630D005B9E3066A4" modified="2015-04-29" version="1">MTRITVSTFKLTVDQLNALKAKAAANSSGTKYSSYNILAAHIWRCVSKARGLSDDQPTKMYFPVDARSKLNPPLPPGYFGNAIFINALVTQAGDLNTESFLDTIKRIHEGLKKINDEYLRSALDYIETVSDLSTLVRGPHTFRCPNLAVNSWLWLPMYEADFGWGRPIHTGPADVSHEGKVLILPTPINDGSLLVATRLGISHMSCFEKLLYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJK7</accession>
    <name>A0A0D2UJK7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G2332001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJK7"/>
    <dbReference type="STRING" id="29730.A0A0D2UJK7"/>
    <dbReference type="Gramene" id="KJB68221">
        <property type="protein sequence ID" value="KJB68221"/>
        <property type="gene ID" value="B456_010G2332001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SPHRAYK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB68221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="15805" checksum="58778CE01CD2780E" modified="2015-04-29" version="1" fragment="single">MDNSDENSIVKWGKMGASLNRLYKQQAIGCKPPFLVPFFGMFGYGGPIASMNLGSCVEVSSKTKQSKKVYKLRLARKALLGNSGSECSWSTDGGIRDPLDEEIKESPHGSFTKVVILNPVVRNLDISKLQRKLKDIYFPYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UMZ7</accession>
    <name>A0A0D2UMZ7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_011G054700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RING-type zinc finger family. ATL subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UMZ7"/>
    <dbReference type="STRING" id="29730.A0A0D2UMZ7"/>
    <dbReference type="Gramene" id="KJB70034">
        <property type="protein sequence ID" value="KJB70034"/>
        <property type="gene ID" value="B456_011G054700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SRVHHEV"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46539:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ATL42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252948" description="RING-type E3 ubiquitin transferase" evidence="12">
        <location>
            <begin position="17"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB70034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="121" mass="13656" checksum="A81C1B315574CB47" modified="2015-04-29" version="1">MLSVILVFMALLVVSCLHVYNNWFGSTGNSHGVEYCVVCLSKVSKGEKLRWLRCRHCFHVHCIDAWLKVGTTCPICRVNVAPKRNFIISSMVSLAKRVGQWIENPLSSELTVAFCESFGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNV3</accession>
    <name>A0A0D2UNV3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G172500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB57625"/>
        <property type="gene ID" value="B456_009G172500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768108"/>
    <dbReference type="eggNOG" id="KOG1198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF8">
        <property type="entry name" value="OS02G0805600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="10"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="325" mass="34626" checksum="8C87F1CFEED5C2CB" modified="2015-04-29" version="1">MKAVVITSPGDPEVLQLQEVEEPEIKDDEVLIKTEAAALNHGDIYQRQGFYPPPEGASTFPGLECSGIIEAVGENVSRWKVGDKVCALLSGGGYAEKVAVPAGQVLPVPSGVSLSDAASLPEVACTVWSTVFTMSRLCPGETLLIHGGSSGIGTFAIQIAKFKGAKVFVTAGDERKLAFCNDLGADLCINYKTEDFVVRVKEETEGKGVDVILDCVGAAYLQRNLDCLNVDGRLFIIGSISGFVAELNIAAMFAKRLSIQAAALRTRSVEEKASIVKEVEKNVWPAIMSGKVKPVVPQRFPLGEAAEAHRLMESGNHIGKILLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXR1</accession>
    <name>A0A0D2UXR1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Remorin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G333200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the remorin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXR1"/>
    <dbReference type="STRING" id="29730.A0A0D2UXR1"/>
    <dbReference type="Gramene" id="KJB60955">
        <property type="protein sequence ID" value="KJB60955"/>
        <property type="gene ID" value="B456_009G333200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB60956">
        <property type="protein sequence ID" value="KJB60956"/>
        <property type="gene ID" value="B456_009G333200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765891"/>
    <dbReference type="eggNOG" id="ENOG502QTDR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNCKPRN"/>
    <dbReference type="OrthoDB" id="687404at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005516">
        <property type="entry name" value="Remorin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471:SF52">
        <property type="entry name" value="F12A21.28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31471">
        <property type="entry name" value="OS02G0116800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03763">
        <property type="entry name" value="Remorin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Remorin C-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="290"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB60955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="375" mass="41533" checksum="107EDC371632A567" modified="2015-04-29" version="1">MRSTEDKGYYEISSSSGISFEFHKGNGATNRGSHHRTGGFGKPTPSKWDDAQKWLVGLSRGRNKGQPETTPRNSNADDRRLIALVPQKEQDCSSSEGEGSAAEETNGSAMAATAVAAVPSEYQDETKQVDCDESIWPINYKPANQNSTSVVRSVCVRDMGTEMTPAASQEPSRTATPIRAMSPSARNPTPITSGSSTPVRCRYGQACAENHQAGTTTSTDAKGEHETNGASRGNGSNGLHEQESRIHENNNSDQVSKQNTLETRAMAWDEAERAKYMARYKREEVKIQAWENHEKRKAEMEMKKMEVKAERLKARAKEKCANKLAATRRIAEEKRANAESKLNEKAMRTSERADYIRRTGHLPSSFSFKLPPLCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V625</accession>
    <name>A0A0D2V625_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G055700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V625"/>
    <dbReference type="Gramene" id="KJB64540">
        <property type="protein sequence ID" value="KJB64540"/>
        <property type="gene ID" value="B456_010G055700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S71B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNCECAL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121">
        <property type="entry name" value="HOMEODOMAIN PROTEIN 8, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35121:SF4">
        <property type="entry name" value="SWIM-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="107" mass="12090" checksum="D91C73498D7B592B" modified="2015-04-29" version="1">MAADQMIFRCVFEGSISMQDCLIERRPYHRNCECALHNLKGICISTCTSRTTDISFPTKQPWNDCFLSFSAAKFSSQSPLLPNASFTKTIEIIDSASVLYEREAEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V9F3</accession>
    <name>A0A0D2V9F3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G050400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V9F3"/>
    <dbReference type="STRING" id="29730.A0A0D2V9F3"/>
    <dbReference type="Gramene" id="KJB79451">
        <property type="protein sequence ID" value="KJB79451"/>
        <property type="gene ID" value="B456_013G050400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB79452">
        <property type="protein sequence ID" value="KJB79452"/>
        <property type="gene ID" value="B456_013G050400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB79453">
        <property type="protein sequence ID" value="KJB79453"/>
        <property type="gene ID" value="B456_013G050400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782947"/>
    <dbReference type="eggNOG" id="KOG2842">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="686784at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF13">
        <property type="entry name" value="DEVELOPMENTAL REGULATOR FAMILY PROTEIN _ IFRD FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB79451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="441" mass="49732" checksum="95F163C2BD0E12C9" modified="2015-04-29" version="1">MDKRRNSKGGQRSKRGILLDHDDDARGDLHNFQGPRKTLHDYFIDLSGKRASVREEALSTILKALTLNIEQNFVELNFVTLVYQCLHSIKKGSPTEMKQAAHIIGLLSMITTSVEKVHEAYEDVLTALSQGGLKPKLKTLEILGCLTVVTFFGASNSDETESVMKLLWDLINPGTDSSIERKDSPAVLTAMISAWSFLLSTIDGWRLSHKNWQGAITYFSNILDSNDEALCAAACEALALVFESNCLEKFSSATKDSNKELKDNIIKQLRSRLSETGNERISSQDPRTGFNSASAALDFLEDEKCANTHVTIGGQKLILSTWSQKVQLKFLKHFLGNDGFVKHMMENENFHSVFDFLPERRNAWGNVLYVPEREEVTISLFQPMVARHNDCSLLPLLTRDKQLAKKKTMSPNSHLSKARTQLLKKQRDLSLKEREIDCFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VDC8</accession>
    <name>A0A0D2VDC8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G103900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB80559.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="110" mass="12448" checksum="BEB9BAB4FDCDC9A5" modified="2015-04-29" version="1">MAAVADNSGEAAVANGNNNLVVETSKSESKEFNVQKLVDMFTKLNPLAKEFFPSSYHHNPTKTGDFNQAPVNKQGNENFPNGRRRNNYNQGRRKLNGKAFRAQKVFFFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VDW9</accession>
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        <recommendedName>
            <fullName evidence="3">Peptidase C14 caspase domain-containing protein</fullName>
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        <name evidence="5" type="ORF">Gorai_003023</name>
    </gene>
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        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB81456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0602857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_013G146600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782259"/>
    <dbReference type="eggNOG" id="KOG1546">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12660:FF:000007">
        <property type="entry name" value="Metacaspase-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="3"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
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        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB81456.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0602857.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VEH2</accession>
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        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
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    </gene>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB81786">
        <property type="protein sequence ID" value="KJB81786"/>
        <property type="gene ID" value="B456_013G161000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RTRMHRW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052101">
        <property type="entry name" value="Plant_StressResp_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47983:SF7">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47983">
        <property type="entry name" value="PTO-INTERACTING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB81786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="143" mass="16292" checksum="6B3EE1F2ABA726B4" modified="2015-04-29" version="1">MKVVWNYVGTYTSSPGYFVQLENPDGLFLKKRTRMHRWLCCSCQVEENYQSRENEHLKCNSDGHQKNSKVVSPIKPEERKSSSLIEVPALSLEELKEKTDNFRSNALIGEGSYGRVYYANLNDGKTVAVKKLDVSTEPNTLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VI58</accession>
    <name>A0A0D2VI58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3HC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G047800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VI58"/>
    <dbReference type="STRING" id="29730.A0A0D2VI58"/>
    <dbReference type="Gramene" id="KJB69872">
        <property type="protein sequence ID" value="KJB69872"/>
        <property type="gene ID" value="B456_011G047800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69875">
        <property type="protein sequence ID" value="KJB69875"/>
        <property type="gene ID" value="B456_011G047800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB69876">
        <property type="protein sequence ID" value="KJB69876"/>
        <property type="gene ID" value="B456_011G047800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4765">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCINTGS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF16">
        <property type="entry name" value="F20D23.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C3HC-type" evidence="4">
        <location>
            <begin position="79"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="446"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="515"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="727"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="929"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="779"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="826"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="943"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB69875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="959" mass="102686" checksum="89EFC6726286CB52" modified="2015-04-29" version="1">MREEVISSGGTIDPTPAASSAGASSPAVPTNVGSVDWSGHGQNSKAASQSCVGSQAPRISFSTSAGGSALGSSRTSCRPWERGDLLRRLATFKPMNWFGKPKVASSLACAQRGWVNIDVDKIVCETCGACLHFASSPSWATSEVEDAGEAFSKQLDIGHKVSCPWRGNSCPESLVQFPPTPQSALIAGYKDRCDGLVQFQSLPIIATSAMEHMRVSRGPQVDRLLSLLQNYVSEFESRSESVPELDVTRDGAFCLYSRSQKLISLCGWEPRWLLNVQDCEEHSAQSARNGCSFGPNRAQVHLSQDPGPSKNALAPSAKDTGKNKVLVMESRSEFRVPLLDCSLCGATVRILDFLIVPRPARVAPNNIDIPDTSKKMGLTRGLSAASGISGWVAADDPEKELTEDRDEVGTTDERKLVPKTDVDLNLTMAGGLSFYKLGRATSSRNMNDADMGRDLMIGQPSGSEVGDRAASYESRGPSPRKRSLEIGASSDDRPQLCTQQADSVEETVIDRDGDKFNDCRQYSAGPSKRARDSDFFDTYCSPYPRDSSEAGPSHSVGFETHGDGGNRVALFRQGSNQVIEIPSVRDSMRASSVIAMDTLCHSAGGDSMESVENYRGDVDDIHFPSSSTYGHLDMNETSELNYSNQAQQSICFQPAAEEVPGEMGISSTNDGEEIFNAEPETVTAQARDGLSFGISGGSVGMCASHEAEIHGADVSVHRTDSVVGDVEPRIEDVENQGQTGESAPDPGLMDEVVPGEINREDPHGDSQEMLSRSLGRADSGSKVDGSVKAESVESGEKISQSCKLAPDNGAHPSLSCNANMYSGNETPKKEEKDAGKSSSINNCPEPESDFAVANGIGPPKGESNYEEAVEFDPVIHHNQFCPWVNGTVAAAGCNGSSADVVALCGWQLTLDALDALRSQGHIPVQTVQSESAASLYRDDHQTPGKKLHRRRPMNKNHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VIC6</accession>
    <name>A0A0D2VIC6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G212300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VIC6"/>
    <dbReference type="Gramene" id="KJB82764">
        <property type="protein sequence ID" value="KJB82764"/>
        <property type="gene ID" value="B456_013G212300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82765">
        <property type="protein sequence ID" value="KJB82765"/>
        <property type="gene ID" value="B456_013G212300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82766">
        <property type="protein sequence ID" value="KJB82766"/>
        <property type="gene ID" value="B456_013G212300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82768">
        <property type="protein sequence ID" value="KJB82768"/>
        <property type="gene ID" value="B456_013G212300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB82769">
        <property type="protein sequence ID" value="KJB82769"/>
        <property type="gene ID" value="B456_013G212300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782278"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NDTRNGC"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000504">
        <property type="entry name" value="E3 ubiquitin-protein ligase arkadia"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
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    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF136">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
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    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="48"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="192"/>
            <end position="212"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB82764.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="482" mass="52989" checksum="D36C3004254139DC" modified="2015-04-29" version="1">MDEYGGKRGVGGLGKGSGLVLNDHVNNRERNARFCNRIGCGARLNSMNDTPNGCSRNGKGIIGSSSRVNPTVSNNRKSSINPQKKLSSQLETSSVRDELQVSELVPQSESGNVDSWEVRSSGVASSTRSRRNMIQRSPSASVGLATRVNASRYGLRNLRCRSISDVVPSGCSSSDSSIRSREDTVKTRNSDGEGSSSGSSRGKKLSGSSLEGQNNVPSHGVFISADSRQARNWRDSGVAASVRTRRSNSSYGRGRFSNQANGNRLSSNEYHVIMPQVPRSDIPINLNDPVSTEIASTRASSYTQPDNISESLLDTMPSSPSEVGVNRDSFWHYNIDGIGEVLLALERIEQDEDLTHEQLLALETTLFLDGLNFYDQHSDMRLDIDNMSYEELLDLEERMGNVSTVLSEEALSKCLMKSIYEGASVDCDGEKDDTKCSICQEEYVNGDEVGMLQCEHRYHVTCIQNWLQVKNWCPICKFSPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VKH2</accession>
    <name>A0A0D2VKH2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">40S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G094800</name>
        <name evidence="5" type="ORF">Gorai_005658</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB70895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0599438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="KJB70895">
        <property type="protein sequence ID" value="KJB70895"/>
        <property type="gene ID" value="B456_011G094800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777746"/>
    <dbReference type="eggNOG" id="KOG0187">
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    </dbReference>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS17"/>
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        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
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    </dbReference>
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        <property type="entry name" value="Rps17e-like"/>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S17E"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB70895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0599438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16090" checksum="BE8D036A08CAE92D" modified="2015-04-29" version="1">MGRVRTKTVKKSSRQVIERYYSRMTLDFHTNKKIIEEVAIIPSKRLRNKIAGFSTHLMKRIQKGPVRGISLKLQEEERERRMDFVPDESAIKVDQIEVDKETLDMLSVLGMADIPGLVKVDPVAVAVPQIGFGRGGGPGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VL52</accession>
    <name>A0A0D2VL52_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G111200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VL52"/>
    <dbReference type="STRING" id="29730.A0A0D2VL52"/>
    <dbReference type="Gramene" id="KJB71220">
        <property type="protein sequence ID" value="KJB71220"/>
        <property type="gene ID" value="B456_011G111200"/>
    </dbReference>
    <dbReference type="OMA" id="ISPYDTH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053258">
        <property type="entry name" value="Ca-permeable_cation_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34115">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34115:SF13">
        <property type="entry name" value="RPB1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="192" mass="22538" checksum="6A8469DBC8773BD1" modified="2015-04-29" version="1" fragment="single">NSDNSGMTNHKLRNFSLRMAVFHALLKIKFQSERNIESPFETQSVIVAAFVICILLYATTLCTPYFPELIDDINLLAGSLATILLTFILFPGLGWVIIVIWVIFFVKLVCRAIGKFCQLYHDMPSISDLFNRVFLGRQAHQNEERLLPLHACLYYFYLITNLARKRSKSYYLRKIIWYTVSEIFRLYKYNWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWH5</accession>
    <name>A0A0D2VWH5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G070700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWH5"/>
    <dbReference type="STRING" id="29730.A0A0D2VWH5"/>
    <dbReference type="Gramene" id="KJB76055">
        <property type="protein sequence ID" value="KJB76055"/>
        <property type="gene ID" value="B456_012G070700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1R5">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKILEVE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024752">
        <property type="entry name" value="Myb/SANT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704:SF37">
        <property type="entry name" value="HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31704">
        <property type="entry name" value="MYB/SANT-LIKE DNA-BINDING DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12776">
        <property type="entry name" value="Myb_DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb/SANT-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB76055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="33539" checksum="4175471ADFE38AB5" modified="2015-04-29" version="1">MWDKRLTNIFCDICIKEILKGNRPGTHFTKDGWLKIMTNFEKETGKIFSQRQLKNRWDALKKEWKAWKKLKGEDTGLGWNPIKRTVDASNEWWESRVVPEAKKFKTSGIDPEFEGKLDQMFMGIVATGDKAWAPSSSTLRSDFFEDVNNEIPKESEEENMRNDVHISNDVQIDGNSQKRKNPETSSPHFKTGRKKSSKQIGGAARLSSQIEKLCNAADNMSQVTSSLTPVMDPYGIPQTVKMLDRMSEEVPEASPLYFFALRLLLNKAKRIMFLSINPKIRALWLKTEMKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W4S0</accession>
    <name>A0A0D2W4S0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_013G104200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W4S0"/>
    <dbReference type="STRING" id="29730.A0A0D2W4S0"/>
    <dbReference type="Gramene" id="KJB80563">
        <property type="protein sequence ID" value="KJB80563"/>
        <property type="gene ID" value="B456_013G104200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80564">
        <property type="protein sequence ID" value="KJB80564"/>
        <property type="gene ID" value="B456_013G104200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80565">
        <property type="protein sequence ID" value="KJB80565"/>
        <property type="gene ID" value="B456_013G104200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784252"/>
    <dbReference type="eggNOG" id="ENOG502QV8R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQVFKAN"/>
    <dbReference type="OrthoDB" id="1904319at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF186">
        <property type="entry name" value="MUDR FAMILY TRANSPOSASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="627"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB80565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="759" mass="86571" checksum="88B9C25AEC6255CF" modified="2015-04-29" version="1">MANHEMVIEQKQDLSLRQNQYVGMGHDANFVLGRNHDLLRSEQIPDVDLVIRPAHDHGHKLSTSQTCTNDVALLRDNLHDYEENGLDMDQINYPGAEEDRAGVEKHDDQFPAVVQDHELGFDGTELTLVKNQDISDNLNSDLQLNQEMSIEPVSYLFRQQEQMIVGSSMLQHRLLFLGENHELTVGKEFTDVHSCRRALRDAAIALRFEIQTIKSDKTRFTVKCASEGCPWRIHAAKLPGVPTFTIRTIHDQHTCGGITHLGHQQASVQWVADAVAESIKENPHYKPKEILEEIHRVHGITLSYKQAWRGKERIMASVRGSFEEDFRLLPQYCHMIRRTNPGSIARVYGYPVDNCFQRLFISYQASIYGFLNACRPLIGLDTTLLKSKYLGSMLFACGFDGYGAVFPLALAVVDEENDDNWMWFLAELHDLLEINAENMPRLTILSDRQKGVVDAVEANFPTAFHGFCMHHLVDCFQKEFNSSVLTNLFWEAAYALTRTEFEKKLIDIQAISPEATTWIQNIPPHLWATSHFEGTRMGHLAANIVECLSAWIAEAYSLPIIQMMECIRRQLMTCFNERRETSMQWTGNLVPPAERIVLEAYDRACTYQVFKANESEFEVRCPNDGSFVVDIRTRSCYCRGWELSGLPCAHAIAVLLSCRQNVHRFTESCFTVTSYRKAYSQTIHPVPDKALWKEMSEQSPNEGSKDVEVTIKPPRLLQPPARPKKRRARAENAGRAKRMVHCSRCNQTGHFRTTCTAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W9Q9</accession>
    <name>A0A0D2W9Q9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
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                <person name="Byers R."/>
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                <person name="Wang Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M2T6"/>
    <dbReference type="STRING" id="29730.A0A0D2M2T6"/>
    <dbReference type="Gramene" id="KJB11262">
        <property type="protein sequence ID" value="KJB11262"/>
        <property type="gene ID" value="B456_001G250400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3436">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CESNFPM"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF30">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="13013" checksum="453308011CC5EDC6" modified="2015-04-29" version="1">MSKTELLSQLKDLKAELALLRVAKVTDGAPNKLSKIKVVRLSIAQVLTVISQKQKSALREAYKKKKFLPLDLRPKKTRAIRRRLTKHQASLKTQREKKKEMYFPLRKYAIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M7K5</accession>
    <name>A0A0D2M7K5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G066900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M7K5"/>
    <dbReference type="STRING" id="29730.A0A0D2M7K5"/>
    <dbReference type="Gramene" id="KJB13297">
        <property type="protein sequence ID" value="KJB13297"/>
        <property type="gene ID" value="B456_002G066900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778733"/>
    <dbReference type="eggNOG" id="KOG0542">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSHHLGF"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051274">
        <property type="entry name" value="3-5_Exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044">
        <property type="entry name" value="3'-5' EXONUCLEASE ERI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23044:SF61">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="4">
        <location>
            <begin position="122"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="337" mass="38810" checksum="449B81665F3B3A27" modified="2015-04-29" version="1">MAYLTRIPVGRIFGFWSRSFSSPIKNPFFSSTLSHVPSYKISTTAHYSSPSPSPPPPLSAAMNTQVFSSSSRWRPMCLYFTQGKCTQMDDPSHLEKFNHDCSKDLQVNGTDIEKKCSQNVDFLLVIDLEGKVEILEFPVLLIDAKSLSLVDFFHRFVRPTKMSEQAVNKYIEGKYGEIGVDRVWHDTAQPFKEVMQQFEAWLSQHNLWEKEKGSRLTRAAFVTCGNWDLKTKIPQQCEVSGIKLPPYFMEWINLKDVYLNFYGREARGMMSMMKQLEIPLLGCHHLGIDDSKNIARVLQRMLVDGALMQVTAKRNPGSQKVEFLFENRIQHPSRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MC99</accession>
    <name>A0A0D2MC99_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G172600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MC99"/>
    <dbReference type="SMR" id="A0A0D2MC99"/>
    <dbReference type="STRING" id="29730.A0A0D2MC99"/>
    <dbReference type="Gramene" id="KJB15362">
        <property type="protein sequence ID" value="KJB15362"/>
        <property type="gene ID" value="B456_002G172600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785640"/>
    <dbReference type="eggNOG" id="KOG2839">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESDESCQ"/>
    <dbReference type="OrthoDB" id="2011998at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Reddy U.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the small heat shock protein (HSP20) family.</text>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
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        <property type="entry name" value="HSP20-like_chaperone"/>
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    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="HEAT SHOCK PROTEIN 26"/>
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    <dbReference type="PANTHER" id="PTHR43670:SF118">
        <property type="entry name" value="HSP20_ALPHA CRYSTALLIN FAMILY PROTEIN"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
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    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="159"/>
            <end position="177"/>
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    </feature>
    <feature type="domain" description="SHSP" evidence="8">
        <location>
            <begin position="3"/>
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        </location>
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        <location>
            <begin position="90"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU003616"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
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    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB26627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0584732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="187" mass="21064" checksum="3AE76DFAEEC63251" modified="2015-04-29" version="1">MSHSYQDVEPEFQYHKGETHDIIEFQVKDFKKDQLRVHFSSKGVLTVSGERPQEGGKRIRFRKDINFPKDCEPNEIRAKLSSGVLFITIPKKDAPQPPQRDSLKQVQQQDNGKLKQGGSSSEEAKGAMATPNENAAMPKPESKSFISGLKMEKKTALKVVANVTVVSLVFVVLFYVYKIYAPVIMHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N4J7</accession>
    <name>A0A0D2N4J7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_001G019800</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N4J7"/>
    <dbReference type="STRING" id="29730.A0A0D2N4J7"/>
    <dbReference type="Gramene" id="KJB07391">
        <property type="protein sequence ID" value="KJB07391"/>
        <property type="gene ID" value="B456_001G019800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07392">
        <property type="protein sequence ID" value="KJB07392"/>
        <property type="gene ID" value="B456_001G019800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07393">
        <property type="protein sequence ID" value="KJB07393"/>
        <property type="gene ID" value="B456_001G019800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QTEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CISKTYT"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033612">
        <property type="term" value="F:receptor serine/threonine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010286">
        <property type="term" value="P:heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048827">
        <property type="term" value="P:phyllome development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001558">
        <property type="term" value="P:regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090567">
        <property type="term" value="P:reproductive shoot system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010103">
        <property type="term" value="P:stomatal complex morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000290">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000288">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000077">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000107">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000219">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050647">
        <property type="entry name" value="Plant_LRR-RLKs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48056:SF6">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395372" description="non-specific serine/threonine protein kinase" evidence="18">
        <location>
            <begin position="23"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="650"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="678"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB07393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="983" mass="108370" checksum="050BC046979F0F11" modified="2015-04-29" version="1">MMTSVFHLEFVFLVSLFCLGFAFVDSEDGTTLLEIKKSFKDVDNVLYDWTDTPSSDYCVWRGVTCDNVTFNVVALNLSGLNLDGEISTAIGKLKDLVTIDLRGNRLSGQIPDEIGDCSSLKSLDLSFNELYGDIPFSISKLRQLEFLVLKNNQLIGPIPSTLSQIPNLKVLDLSQNKLSGEIPRLIYWNEVLQYFGLRGNNLVGTLSPDMCQLTGLWYFDVRNNSLTGNIPQNIGNCTAFQVLDLSYNQLTGEIPFNIGFLQVATLSLQGNRLSGKIPSVIGLMQALAVLDLSCNKLSGPIPPILGNLTYTEKLYLHGNQLSGSIPPELGNMTKLHYLELNDNYLTGLIPPELGKLTELFDLNVANNHLEGPIPENLSSCTNLNSLNVHGNKLNGTIPPAFERLESMTYLNLSSNDIKGFIAIELSRIGNLDTLDISNNKISGSIPSSLGDLEHLLKLNLSRNNLTGVIPAEFGNLRSVLEIDLSNNHLSGIIPRELAQLQDLYSLRIENNNLSGDLMSLINCISLTNLNVSHNNLAGDIPTSNNFSRFSPDSFIGNPGLCGYWLSSTCHGSHPAERVSISKAAILGIALGALVILLMILIAACSPHNPTPFPDGSLDKPVTYSRPKLVILHMNMALHVYEDIMRVTENLSEKYIIGSGASSTVYKCVLKNCRPVAIKRLYSHYPQCLKEFETELETIGSIKHRNLVSLQGYSLSPSRNLLFYDYMENGSLWDLLHVSTKRKVLGWDIRLKIALGAAQGLAYLHHDCSPRIIHRDVKSSNILLDKDLEAHLTDFGIAKSLCISKSHTSTYVMGTIGYIDPEYARTSRLTEKSDVYSYGIVLLELLTGRKPVDNESSLHHLILSKAANDAVMETTDPEITATCKDLGAVKKVFQLALLCTKRHPLDRPTMHEVTRVLGSLRPLEPPAKQPTTIPPAPLPSTKVTSYMDEYANLKTPHLVNCPSMSTSDAQLFINFGEVISRNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NC50</accession>
    <name>A0A0D2NC50_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G133700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NC50"/>
    <dbReference type="STRING" id="29730.A0A0D2NC50"/>
    <dbReference type="Gramene" id="KJB30212">
        <property type="protein sequence ID" value="KJB30212"/>
        <property type="gene ID" value="B456_005G133700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794103"/>
    <dbReference type="eggNOG" id="ENOG502QVR4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF38">
        <property type="entry name" value="D111_G-PATCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="G_PATCH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="G-patch" evidence="5">
        <location>
            <begin position="434"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="460"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB30212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="483" mass="53450" checksum="1692D01AC73BD63A" modified="2015-04-29" version="1">MKRKDKESDKTMAVSTELDLQSSSDCSFVWDPQTHLYFHASSGFYHDPDAGWYYSSRDGLYYTFENGNYVLLDMEGAVADNSVLDEPCATASYNGPEYNRSSSQGNEVDAQNTTINVADESTSTGPIEDTSAQASEQPPPPSEWLEDTLIDLYLSGYNLAANSAADASISLETDEKENFKFPTDGNDEMYELEEGEWIPEESFGLGGSSEVVPYEGDTWDEENWRAQYGQVTRCKDEPLLEFPVVDLWDWSMVTKPKEDGKKQVARLIGRLVKRSAKVHPSVPLGGGLLKTAPICEVHLDLVRVRTGQVYKLRTPCPRYLASLSTYDSSDPTKDWGFPDLLVNKKSFVQFKSRQKQKSEATREKGLKDLSMLSDQLSTSLKGSHAYRDRAAERRALRGGFGLGPGQKNAGSDHDNDPTCIEDAKAEALNMSFGAGSYARRIMEGMGWKEGEALGSTTKGLTEPLQPTGNIGNAGLGWPQTRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGM4</accession>
    <name>A0A0D2NGM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="12">HMG-CoA reductase</shortName>
            <ecNumber evidence="12">1.1.1.34</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G014700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-mevalonate + 2 NADP(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15989"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.34" evidence="12"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2NGM4"/>
    <dbReference type="Gramene" id="KJB12363">
        <property type="protein sequence ID" value="KJB12363"/>
        <property type="gene ID" value="B456_002G014700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB12365">
        <property type="protein sequence ID" value="KJB12365"/>
        <property type="gene ID" value="B456_002G014700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773783"/>
    <dbReference type="eggNOG" id="KOG2480">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CKASEYS"/>
    <dbReference type="OrthoDB" id="310654at2759"/>
    <dbReference type="UniPathway" id="UPA00058">
        <property type="reaction ID" value="UER00103"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00643">
        <property type="entry name" value="HMG-CoA_reductase_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3270.10:FF:000002">
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="3-hydroxy-3-methylglutaryl-coenzyme A Reductase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3270.10">
        <property type="entry name" value="HMGR, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.420">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004554">
        <property type="entry name" value="HMG_CoA_Rdtase_eu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023282">
        <property type="entry name" value="HMG_CoA_Rdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00533">
        <property type="entry name" value="HMG_CoA_R_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572:SF44">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="NAD-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="Substrate-binding domain of HMG-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00318">
        <property type="entry name" value="HMG_COA_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50065">
        <property type="entry name" value="HMG_COA_REDUCTASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="585" mass="62701" checksum="286E69D376557DBE" modified="2015-04-29" version="1">METHRRSSINSVRSHKPARPIALEDDSTKASDALPLPLYLTNAVFFTLFFSAVYFLLCRWREKIRSSTPLHVVTFSEIVAILASVASFIYLLGFFGIDFVQSLVLRPSADVWATEDDEVESEVLLRNEDARHVPCGQALDRSIRSLQPPAPIVTAEKVFDEMPVTVMTEEDEEIIRSVVCGMTPSYSLESKLGDCKRAAAIRREALQRITGKSLSGLPLDGFDYESILGQCCEMPVGYVQIPVGIAGPLLLNGREYSVPMATTEGCLVASTNRGCKAIHLSGGATSVLLRDGMTRAPVVRFGTAKRAADLKLYLEDPENFETLACVFNRSSRFARLQSIKCAIAGKNLYLRFSCFTGDAMGMNMVSKGVQNVLDFLQTDFPDMDVIGISGNFCSDKKPAAVNWIEGRGKSVVCEAIINGDVVTKVLKTSVESLVELNMLKNLTGSAMAGALGGFNAHASNIVTAVYIATGQDPAQNVESSHCITMMEAVNGGKDLHVSVTMPSIEVGTVGGGTQLASQSACLNLLGVKGASKESPGANSILLATIVAGAVLAGELSLMSALAAGQLLKSHMKYNRSSKDVSKVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NP04</accession>
    <name>A0A0D2NP04_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 20">Peroxidase</fullName>
            <ecNumber evidence="4 20">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_002G164800</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 20">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="17 20">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17 20">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="17 20">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 20"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NP04"/>
    <dbReference type="STRING" id="29730.A0A0D2NP04"/>
    <dbReference type="Gramene" id="KJB15208">
        <property type="protein sequence ID" value="KJB15208"/>
        <property type="gene ID" value="B456_002G164800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787274"/>
    <dbReference type="eggNOG" id="ENOG502QR74">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EEMSAFN"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000007">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000008">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31517:SF86">
        <property type="entry name" value="PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17 20" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 19" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 20" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="12 17 20" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 20" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112639" description="Peroxidase" evidence="20">
        <location>
            <begin position="25"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="21">
        <location>
            <begin position="25"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="17">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="18">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="35"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="68"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="122"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="19">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB15208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="331" mass="36922" checksum="4822932CF2B99CB9" modified="2015-04-29" version="1">MTFPNLVLLFKLFSFLLLFRSTQSKLSADYYNKTCPKFQNIMQTILAEKQLSAPTTAAATLRVFFHDCFVNGCDSSMLIASNAFNKSERDANVNLSVAGDAFDLITRVKTALELECPGVVSCSDILAVSARDLVVMVGGPFYEVVLGRKDSRESNPSIVDKNLPKALTPMNELLSLFSSKGFSAEEMVALVGAHTIGFSHCKEFANRIFNFSKTSEFDPAYNPVFAQGLRKLCANYTKSPAMSAFNDVYTPGKFDNMYYKNLQKGLGLLSSDQAMVTDNRTKPFVDRFAANETAFFDMFARSMEKLSVYKVKENNDGDVRRRCDQFNTLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NR32</accession>
    <name>A0A0D2NR32_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G213900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NR32"/>
    <dbReference type="Gramene" id="KJB16138">
        <property type="protein sequence ID" value="KJB16138"/>
        <property type="gene ID" value="B456_002G213900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB16139">
        <property type="protein sequence ID" value="KJB16139"/>
        <property type="gene ID" value="B456_002G213900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786070"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYRECDS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47941">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="281"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="421"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB16138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55655" checksum="E5C93E9E14005B00" modified="2015-04-29" version="1">MATQILKTHHVLSRTPKEPLIPLYFFSSSAFPDTTSPPADQSDPISTVTSILTHNRSKSRWSTVLTLFPSGFTPFQFSQITLQLKNNPHLALRFFLFTQHKSLCNHDLSSYSTIIHILSRARLKTRARELIRLAIRTPGIDNEPTHFKLFELLVKTYNQCGSAPFVFDLLVKSCLQMKRLDGSIEIVRMLMSRRISPQVCTCNALISEVSKCCGASKGFEVYKEVFVVGNGESESDVKRVSKVRPNVHTFNALMLCFYREGLLEKVREVWCVMESLGCVPNSYSYSVLMAAFCEEGKVREAEDLWAEMKVKGLEPDIVAFNTLIDGLCKSGEIIRAEELFTEMELNGIKATCVTYENLINGYCKAADINSAMLIYRDMCRKDFRPQSLTVELLIRGLCDEGMVLEALEIMKAMREVGVCPTGISYELLIKGLCVDGKMEEALKLQAEMVGKGFKLNLEIYDAFIDGYLRQGNEEMVTMLRKEVLETHKEQGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NUT8</accession>
    <name>A0A0D2NUT8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G013400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2NUT8"/>
    <dbReference type="Gramene" id="KJB17738">
        <property type="protein sequence ID" value="KJB17738"/>
        <property type="gene ID" value="B456_003G013400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787520"/>
    <dbReference type="eggNOG" id="KOG0431">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000009">
        <property type="entry name" value="Auxilin-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF87">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="4">
        <location>
            <begin position="1489"/>
            <end position="1553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="938"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="983"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1351"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1229"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="688"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1013"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1351"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1367"/>
            <end position="1382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB17738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1553" mass="178579" checksum="CD86CBEE0A0A5704" modified="2015-04-29" version="1">MENLSHSRKPNRVVSQAAATLNKRTATSNGANNFSGRTVYDDVFGGVQRFGTGGGPTLSPRPEDYSEIFGGFHASRGASIPVLDLPLIDSSNGAMFDVRNPRFNYAEVFGGFDGSDFAATYEELIRQADGGDRHDYDGDSSDEAWMQDETEFLSEGSDHSGNYQYFSNGDYYEPIDSSMEFNISYHKANVRSNRDMSNAVTHVAELHAEPEYAYIIETSLGKTENKSPILHTTDDINLEFTGGVVKKKHLRKTVSHPANGAGEQTFAYDSTQRRYQGKDSCSNESFITISEINLRTQPSHVPPPARPPPHVRVNNGDHQSVKHAVSGEGMGDSSPPFFDVEIDASSAAVASAAAMKEAMDKAQAQLKSAKELLERKREGIENSTKLGSKSDGKGKKERTSKAIDESSDIKDDKVLGIKGKEDNGTKISVREERQKAVKTLAPDSMEGEKLFNVSKYFVVEKHGKESRSIEECGEVDGADEWQEETQFFELVRTDKSRVGFQHTNTDKVFVQSMKFNEPQYKSQKASIGAVEQLESDMKVEAVREDHELEKVERDMKMAKEAKEARRHKGHEKKVKSAQEVGAEENGQSITARKLSGNGKKPNGADELGIREKRVNAQEKENKVEVQRAMEQKERAQQEKEISKYIPNPKRVEGCEEREDEEKSWREVSKQEENDIILERVLVQAENETMLRDAVQQEEKEKKLKEAHEREERRKKEKVARELEEKEKKLKEAHEREENERRLREAREREEIEKKLKEAREREENEKRLREAREREEKEKEKEAHGREEKEKKLKEARELEEKEKKLKEAREREENERRLKEIREREEIEKKEKEVREREEKEKKLKEAREQEENEKRLKEAREREENEKRLKEAREREEKEKEAREREEKEKKEKEARELEESEKIWRMALEQIENEKRLKQARLQEENERRQRMLEEAVEQNDCSKPVKAVQDTEDEVNQKVVEQEVTEELQGVNYVYQQTARGENGKKQKIAKETHRHGEGEDPVISNKVNKQDHINNHKENQLDGNNDQNFEELEETDELVLEGNGKMEAEFRDCERRTEAMGQGGVDGKFNASRTVPCDLEVKANQLRKDDISVLRHQNKGVKKADEAVIGIGQTNAENINSVSEMDSNNDKQRLKSAYEWRERARNIKEAQVSSSLEENKDKYVSAQVVNESVETGRKPEAAKASVVDGKGSTQRTVHQVKVSQNMERKDKNIIESLTPEDKEAERLKRERELELERLRKIEEEIEREREREKDRMAVDSTVLEARERGYAEARERAEKAALERATTEARQRAMADARERLEKACAEAREKSSMEARLRAERAAVERATAEARERAVEKIMAERAASEARERVERSMSDKFSTSSRNSGMRSSYSSSDLKDQHFQSTNSFGGLRYPYASAYNGVEGESAQRCKARLERYQRTAERAAKALEEKNMRDLVAQREQAERNRLAESLDADVKRWSSGKEGNLRALLSTLQYILGPESGWQPIPLTEVITSAAVKKAYRKATLCVHPDKLQQRGASIHQKYISEKVFDLLKEAWNRFNSEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NWN9</accession>
    <name>A0A0D2NWN9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_003G053200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Prevacuolar compartment membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the syntaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NWN9"/>
    <dbReference type="STRING" id="29730.A0A0D2NWN9"/>
    <dbReference type="Gramene" id="KJB18443">
        <property type="protein sequence ID" value="KJB18443"/>
        <property type="gene ID" value="B456_003G053200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787941"/>
    <dbReference type="eggNOG" id="KOG0811">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEVENNP"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000035">
        <property type="entry name" value="Syntaxin-22 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000004">
        <property type="entry name" value="Syntaxin-22 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="14">
        <location>
            <begin position="187"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB18443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="280" mass="31161" checksum="9487AEDDE5CD6B58" modified="2015-04-29" version="1">MSFQDLEAGFARPHPSNYLNSSQQKLRQEIGDTSPSQSVAAGIFKLRTALLAFDRLVNSLATPKDTFELRDKLHKTRLHIGQLVKETSAKLREASEADQDAEPLKKIADAKLAKDFQAALKDFQKAQRLAAERETAYTPSAPKEVLPSSYAAHEVENNSSKSFEQQNLLVTKRQEVVLLENEITFNEAIIEEREQGIKEVQQQISEVNEIFKDLADLVHVQGGMIDDIGSNIENSHSATVQATSHLKRASKIQRANSSTRCLLVLIFGIILLIFIIVVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NXS4</accession>
    <name>A0A0D2NXS4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G241100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the 7S seed storage protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NXS4"/>
    <dbReference type="STRING" id="29730.A0A0D2NXS4"/>
    <dbReference type="Gramene" id="KJB38182">
        <property type="protein sequence ID" value="KJB38182"/>
        <property type="gene ID" value="B456_006G241100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ENPWRGE"/>
    <dbReference type="OrthoDB" id="1912756at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045735">
        <property type="term" value="F:nutrient reservoir activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02245">
        <property type="entry name" value="cupin_7S_vicilin-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02244">
        <property type="entry name" value="cupin_7S_vicilin-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050253">
        <property type="entry name" value="Seed_Storage-Functional"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006792">
        <property type="entry name" value="Vicilin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189">
        <property type="entry name" value="OS03G0336100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31189:SF41">
        <property type="entry name" value="VICILIN C72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04702">
        <property type="entry name" value="Vicilin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0708">Seed storage protein</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0758">Storage protein</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002248405" description="Cupin type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="182"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="386"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="343"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB38182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="590" mass="69626" checksum="6FDD0B030088BA9F" modified="2015-04-29" version="1">MVRNKSACVVLLFSLFLSFGLLCSAKDFPGRRGDDDPSKRYEDCRRRCEWDTRGQKEQQQCEESCKSQYGEKDQQQRHRPEDPQRRYEECKQECRQQEERQQPQCQQRCLKRFEQEQQQSQRQFQECQQHCHQQEQRPEKKQQCVRECREKYQENPWRGEREEEAEEEETEEGEQEQSHNPFHFHRRSFQSRFREEHGNFRVLQRFASRHPILRGINEFRLSILEANPNTFVLPHHCDAEKIYLVTNGRGTLTFLTHENKESYNIVPGVVVSVPAGSTVYLANQDNKEKLIIAVLHRPVNNPGQFEEFFPAGSQRPQSYLRAFSREILEPAFNTRSEQLDELFGGRQSRRRQQGQGMFRKASQEQIRALSQEATSPREKSGERFAFNLLSQTPRYSNQNGRFFEACPREFRQLRDINVTVSALQLNQGSIFVPHYNSKATFVILVTEGNGYAEMVSPHLPRQSSYEEEEEQEEEQEQEQEEERRSGQYRKIRSRLSRGDIFVVPANFPVTFVASQNQNLRMTGFGLYNQNINPDHNQRIFVAGKINHVRQWDSQAKELAFGVSSRLVDEIFNNNPQESYFVSRQRQRASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P6Y7</accession>
    <name>A0A0D2P6Y7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_004G048000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P6Y7"/>
    <dbReference type="STRING" id="29730.A0A0D2P6Y7"/>
    <dbReference type="Gramene" id="KJB22463">
        <property type="protein sequence ID" value="KJB22463"/>
        <property type="gene ID" value="B456_004G048000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0154">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16166">
        <property type="entry name" value="OCRE_SUA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12313">
        <property type="entry name" value="RRM1_RRM2_RBM5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041591">
        <property type="entry name" value="OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035623">
        <property type="entry name" value="SUA-like_OCRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17780">
        <property type="entry name" value="OCRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="284"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="13">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="441"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="12">
        <location>
            <begin position="969"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="205"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="734"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="834"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="754"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="782"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB22463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115956" checksum="7AF14A0E2AED6F4A" modified="2015-04-29" version="1">MDHAPARYPLQRGSDNNSALEGFSAVPVPNYRVRGSYDERRFLDERYSRASFYPRSAYHHYFPEKDNHSPPAAAGVWSQSRGRSYEEEYPRDEDSRHHQKLYVDSYRDLDTYCDHEIAFQDFDKFRDGYRCVDNICDHEFGRPSRYGGRDWEDYSYDYYDYRPHISHQSRDNSCERNYEYSRNSYDSYHKRGSCRDGSWRKRESRDRDSFSRERDQSPHKRHERSWSRSRGCDDRPRSRSPRVWSHGRSHREDSYDDYQNEKTQKQRDREEKYQLEQYSVAPSATIVVKGLSHKTTEEDLCQILAEWGPLRHVRVIKERTSGISRGFAFIDFPSVGAARSMMDKIGDDGLVVDGRKLFFDYSSKPTGGTGGPSAHNNAVKLGHSNHKSTTLPSDWMCTICGCVNFARRTACFQCNEPRTNDAPAADISLSGKRGSESGPTHVLVVRGLDENADDEMLRYEFSKYAPIKDLRLVRDKFTHVSRGFAFVHYHSVGDATKALEATNGTTLEKNGQILRVAYARSIIGPRSGTLGSLQSSSLAAAAIEAAAFSQQYDAVGWTRKEYNPDDKQSTTWQEQAGGSFAVQQDHSALHSGFVWDEASGYYFDAASGFYYDGNTGLYYDGNSGSWFSYDHQSQQYIPCSDRNDNIIPGKESELSREADGSNNSKAITSAPAATVTSVEKAASLPDAVEAAAAAALAAEKKEKEKSREIKLASKSSILANKKKMNNVLTMWKQRSHEGKASRSGLNDNHLSASSEDRPLSAEQHAISKDKFDMMDLKEGDTRSSGVNTTAQATSTWGLGSPAKPRPINNSSGGTLMGVIRGSARVLVKSDIPFPRSSAGVSTSSAGGVAEGSLSSTSDPASMTPFRTDASASGSIAPSTITGSGKRRFSEAPVPPTTNKGQSQTTYRDRAAERRNLYGSSSSTADDIPDGEFWNSNPMPFPPGVGGGRWAVSDDVQSFEVITAKKAIDKNNVGNRMLRSMGWHEGLGMGKDGSGVTEAVEAQGMDKRAGLGIQVKKLDPSLEVQAGDSYKTVIHKKALARFHQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PE64</accession>
    <name>A0A0D2PE64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_007G238600</name>
        <name evidence="7" type="ORF">Gorai_019409</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PE64"/>
    <dbReference type="STRING" id="29730.A0A0D2PE64"/>
    <dbReference type="Gramene" id="KJB44182">
        <property type="protein sequence ID" value="KJB44182"/>
        <property type="gene ID" value="B456_007G238600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804214"/>
    <dbReference type="eggNOG" id="KOG4089">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKFPWTS"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000436">
        <property type="entry name" value="50S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB44182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0590715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="174" mass="19367" checksum="4406A68A1901D982" modified="2015-04-29" version="1">MAGRLGRRVVHFANLPIKLLMPNTFTNITEIALKTIPSASKIEIKRVLESLYGFDVDKVRTLNMDGKKKKRGGFLIARPDYKKAYVTLRTPLSVSENLFPIQVIKEEKDSINKTSKSKSVVEEGEKKKHWLDGKVKDDGADRGKGKGSYASARGGDRRGGGEAKFPWSSMRKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PR94</accession>
    <name>A0A0D2PR94_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G086600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PR94"/>
    <dbReference type="STRING" id="29730.A0A0D2PR94"/>
    <dbReference type="Gramene" id="KJB48777">
        <property type="protein sequence ID" value="KJB48777"/>
        <property type="gene ID" value="B456_008G086600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB48777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="222" mass="24913" checksum="DEAC143C9599E0A3" modified="2015-04-29" version="1">MEINAVLANLQPNYLLHPSSRSSISTTSAAATFLPLSSSLHTRFSNISFPFLFLLTQVLASASCRNINETNSAFKCAAVLSDSYTSEASELADIEWDYLGFGLLQTYYMYMMKCTQGGNFCKGELQRFENIELNPSAGVLNYGQGLFEGLKAYRKEGNTLLFHLEEKALRMRLRAKRMCTPSPTVEQFVEAVKEIVLANKSWVTNSHDLKHEFDLLLAFHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTP7</accession>
    <name>A0A0D2PTP7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_005G156200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTP7"/>
    <dbReference type="STRING" id="29730.A0A0D2PTP7"/>
    <dbReference type="Gramene" id="KJB30708">
        <property type="protein sequence ID" value="KJB30708"/>
        <property type="gene ID" value="B456_005G156200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794358"/>
    <dbReference type="OMA" id="YAIFCTR"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB30708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="12283" checksum="95C3137B578DFB53" modified="2015-04-29" version="1">MSSFALTSRNGRKLQEVEGDEKAPDSASTKAIKTFGLQRKRAEMIQRMSQECLWKEWTHVTELHGVGKYAANAYAIFCTRKGDRVTPTDHMLNHYWNFLYGPKNTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVM4</accession>
    <name>A0A0D2PVM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G191800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PVM4"/>
    <dbReference type="STRING" id="29730.A0A0D2PVM4"/>
    <dbReference type="Gramene" id="KJB31438">
        <property type="protein sequence ID" value="KJB31438"/>
        <property type="gene ID" value="B456_005G191800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794758"/>
    <dbReference type="eggNOG" id="KOG1455">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EPREWDG"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000054">
        <property type="entry name" value="Alpha/beta-Hydrolases superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="124"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="384" mass="42996" checksum="D5E8A906EFD89C54" modified="2015-04-29" version="1">MDLSLTFRSPSPFLLPKSKPSTLSIPLISLKPSPHRLTVAAAAGNMKMIEGVSDELNSIASQNLDYAAARRRVRSAFIPVHQQLDHLLFKMAPTGVRTEEWIERNSKGLEIFFRRWMPEPGVKIKGVVCFCHGYGDTCTFFFEGIARFIAASGYGVYAIDHPGFGLSEGLHGYIYSFDELADNVIEQYAKIKERPEVRGLPCFILGQSMGGAVTLKVHFKDPHGWDGIILVAPMCKIADDVTPSKPVLNFLTFLSKVMPTAKLVPQKDLAELMFRDPRKKKMAVYNVICYDDRVRLRTAVELLNATKEIEEQVDKVSSPLLILHGAADKVTDPVVSQFLYENASSKDKTLKLYEEGYHCILEGEPDDRILTVLNDIISWLDARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q2R3</accession>
    <name>A0A0D2Q2R3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G271000</name>
        <name evidence="14" type="ORF">Gorai_010555</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2Q2R3"/>
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        <property type="protein sequence ID" value="KJB52644"/>
        <property type="gene ID" value="B456_008G271000"/>
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    <dbReference type="eggNOG" id="KOG0761">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:mitochondrial transmembrane transport"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
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    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
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    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
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    </dbReference>
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        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="64"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="322"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
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            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
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            <dbReference type="RuleBase" id="RU000488"/>
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    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB52642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0593620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
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    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="45301" checksum="31145D129D68147B" modified="2015-04-29" version="1">MQAIEMAETQRRTHNPWMSSEQSSRVEINGHDLSVMEPTITDILETELGEPQDQDDNGPTNSNLGIGERAFSAAGAAVLSAIIVNPLDVVKTRLQAQAAGVPYSHPLSNLIGRMAYFGPNTMFADLRCSPSCTRAGVHGTVSICPPDCFQYKGTLDVFNKIIRQEGFSRLWRGTNAGLALAVPTVGIYLPCYDIFRNWMEGLAAQYMPSATPYAPLFAGSLARSLACATCYPIELARTRMQAFKDTQIGKKPPGVFNTLLGVVSDVKGRNPQSSLQGYRVLWTGMGAQLARDVPFSGICWSTLEPIRRKLLGLVGEESNVATVLGANFSAGFFAGSLAAAATCPLDVAKTRRQIEKDPVRALRMTTRQTLMEVWRDGGMKGLFTGVGPRVGRAGPSVGIVVSFYEVVKYVLHNHYASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q708</accession>
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            <fullName evidence="2">monogalactosyldiacylglycerol synthase</fullName>
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    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z,12Z-octadecadienoyl)-3-beta-D-galactosyl-sn-glycerol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:77127"/>
            <dbReference type="ChEBI" id="CHEBI:90506"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:48493"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1,2-di-(9Z-octadecenoyl)-sn-glycerol + UDP-alpha-D-galactose = 1,2-di-(9Z-octadecenoyl)-3-beta-D-galactosyl-sn-glycerol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:52333"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:63775"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:48481"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycerol + UDP-alpha-D-galactose = 1-(9Z-octadecenoyl)-2-hexadecanoyl-3-beta-D-galactosyl-sn-glycerol + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48496"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="ChEBI" id="CHEBI:75447"/>
            <dbReference type="ChEBI" id="CHEBI:90507"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48497"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP + H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17615"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
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            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.4.1.46"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:14946"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Plastid</location>
            <location evidence="9">Chloroplast membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.46" evidence="2"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0593938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2Q708"/>
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        <property type="protein sequence ID" value="KJB53972"/>
        <property type="gene ID" value="B456_009G014700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770833"/>
    <dbReference type="eggNOG" id="ENOG502QPXV">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OMA" id="HITISRQ"/>
    <dbReference type="OrthoDB" id="200404at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <dbReference type="GO" id="GO:0031969">
        <property type="term" value="C:chloroplast membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046509">
        <property type="term" value="F:1,2-diacylglycerol 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17507">
        <property type="entry name" value="GT28_Beta-DGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000111">
        <property type="entry name" value="Monogalactosyldiacylglycerol synthase 3, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009695">
        <property type="entry name" value="Diacylglyc_glucosyltr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050519">
        <property type="entry name" value="Glycosyltransf_28_UgtP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43025">
        <property type="entry name" value="MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43025:SF1">
        <property type="entry name" value="MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06925">
        <property type="entry name" value="MGDG_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Diacylglycerol glucosyltransferase N-terminal" evidence="15">
        <location>
            <begin position="82"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 28 C-terminal" evidence="14">
        <location>
            <begin position="309"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB53972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0593938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="468" mass="53031" checksum="C68272264C6D3B3B" modified="2015-04-29" version="1">MVMKIASPEKVVSITEKVWQRVYGGINNNGYYYHHHRKHRRRCSYESEDEYEVEDGTIQLMQMGAERSKNVLILMSDTGGGHRASAEAIREAFRIEFGDEYRIYVKDVWKEYTGWPLNDMERSYKFMVKHVQLWKVAFHSTSPRWIHSSYLAAIASYYAKEVEAGLMEYKPDIIISVHPLMQHIPLSVLKWKSLQKKVIFVTVITDLNTCHPTWFHPRVNRCYCPSKEVAKRALYDGLEESQIQVFGLPIRPSFARAVLSKDDLRKELELDPDLPAVLLMGGGEGMGPVKKTAMVLGESLYDNDQGKPIGQLIIICGRNKALASTLESLEWKIPVKVRGFETQMEKWMGACDCIITKAGPGTIAEALIRGLPIVLNDYIPGQEKGNVPYVVDNGAGVFTRSPKETARIVSEWFSTKTDELKRMSENALKLAQPEAVFDIVKDIHELACQRGPLANIPYDSTSSLTNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q716</accession>
    <name>A0A0D2Q716_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_002G152600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WIP C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q716"/>
    <dbReference type="STRING" id="29730.A0A0D2Q716"/>
    <dbReference type="Gramene" id="KJB14974">
        <property type="protein sequence ID" value="KJB14974"/>
        <property type="gene ID" value="B456_002G152600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785411"/>
    <dbReference type="eggNOG" id="KOG1721">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CTHATSC"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000523">
        <property type="entry name" value="Zinc finger protein WIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055187">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043584">
        <property type="entry name" value="WIP1/2/3/4/5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059161">
        <property type="entry name" value="Znf-C2H2_STOP1/2_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45878">
        <property type="entry name" value="ZINC FINGER PROTEIN WIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45878:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN WIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22995">
        <property type="entry name" value="C2CH-3rd_BIRD-IDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23115">
        <property type="entry name" value="zf-C2H2_STOP2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="335" mass="38314" checksum="62DF3FE274EA4E92" modified="2015-04-29" version="1">MADNHYSNFFSGWFKFNPLDQHYPSPIHPLQKPNPHPQNSHKNGTNNLNPFLHYRTTYSSPPPSPPVREALPLLSLSPTRHYKDEDGVYQDQDQEQHSCTAMDVNGEDDDETVTVTVALHIGLPSASASELASVLSASSEMTEQDDEYPINRLKKRQYWIPTPSQILIGPSQFSCPVCCKTFNRYNNMQMHMWAHGSQYRKGTESLRGTQPTAMLRLPCYCCAPGCRNNIDHPRPKPLKDFRTLQTHYKRKHGIKPFMCRKCGKAFAVRGDWRTHEKNCGKLWYCICGSDFKHKRSLKDHIKAFGDGHQVYATDDLEEDDDEPASEVEQHNGSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QF79</accession>
    <name>A0A0D2QF79_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-phytyl-1,4-beta-naphthoquinone methyltransferase, chloroplastic</fullName>
            <ecNumber evidence="4">2.1.1.329</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Demethylphylloquinone methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Menaquinone biosynthesis methyltransferase ubiE-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">MENG</name>
        <name evidence="5" type="ORF">B456_002G186100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>demethylphylloquinol + S-adenosyl-L-methionine = phylloquinol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:40551"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28433"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:87844"/>
            <dbReference type="EC" id="2.1.1.329"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Plastid</location>
            <location evidence="4">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.329" evidence="4"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QF79"/>
    <dbReference type="STRING" id="29730.A0A0D2QF79"/>
    <dbReference type="Gramene" id="KJB15591">
        <property type="protein sequence ID" value="KJB15591"/>
        <property type="gene ID" value="B456_002G186100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052624">
        <property type="term" value="F:2-phytyl-1,4-naphthoquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042372">
        <property type="term" value="P:phylloquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01982">
        <property type="entry name" value="MenG_phylloquinone_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032904">
        <property type="entry name" value="MenG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001244">
        <property type="entry name" value="PRK00216.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="253" mass="28669" checksum="AD7D603EE690B1E6" modified="2015-04-29" version="1">MHSLQFSVPLVPTSRFKRHSVRCASDRQQLFNRIAPVYDNLNDLLSLGQHRIWKRMAVSWSGAKTGDSLLDLCCGSGDLTFLMSEKAGADGKVIGLDFSKEQLSIASSRQYLLSKACYNNIEWVEGDALDLPFSNGYFDAITMGYGLRNVVDKRRAMQEMFRVLKPGSRVSILDFNKSMQPFTALFQEWMIDNVVVPTATVYGLAKEYQYLKTSIDEFLTGIGETGLRCRVFLCQTLRDRRRPHGEPSSRTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QG64</accession>
    <name>A0A0D2QG64_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G248900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QG64"/>
    <dbReference type="Gramene" id="KJB38323">
        <property type="protein sequence ID" value="KJB38323"/>
        <property type="gene ID" value="B456_006G248900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RANS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHVDCVH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004146">
        <property type="entry name" value="DC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053192">
        <property type="entry name" value="Vacuole_Formation_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410:SF169">
        <property type="entry name" value="C1 DOMAIN FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32410">
        <property type="entry name" value="CYSTEINE/HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03107">
        <property type="entry name" value="C1_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB38323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="635" mass="73352" checksum="0D44B57D11F34389" modified="2015-04-29" version="1" fragment="single">SPYGGSCYCDFSYKRCDFFVYHCSCGLDFHIKCALFTLNISEQKLQELNHIATKDPSVFLEDGNEELENAVCFGCWLPLGESRYFSVACGFNLHIKCAELPHEINHPFHKEHPLVLQFNIKRFSCKICGETRHRGFLYCCSACTFALHIKCAEQPTLACQETQHEKFVYCCSTCNFSLHTECAFLPPIVKDKIHQHPFTLFQGQPSFVCNACGLEGNYIAYICSTCNLMIHTKCISIPPIIRVRRHYHPIYHNYFISENESKIRDCSFCDVEVNIDYGSYYCLRCNFIAHVKCATKYRDRYYIIEAKDIAGKHDDDLGVNPITCVIEQNEGGEMTRIKHFSHAHDLILSDNVMENDITCDGCMLLILDSFYCCSLQCNFFLHKACAKSPRKKHLWFHGCQELHILVVGYLFKCSICEYDCGGFSYKCNKFNVHICLQCSVIDYRTKHPGHQHPILSNRNQHGRCNGCGETWRSQFSCKHCHFNLDFDCSRLPLSTRHKRHEHPPALTYHEGNDYPKYHYCDLCEKERDPNLWFYHCAICKFSAHPNCVLAIYLFIKPGSMYKGKDHPHPLTFVWKPYRYIVCGKCSEPCEALVLECAEPTCNYVVHWKDVRPPSFGFTSPVELYKAEADAITHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QHH5</accession>
    <name>A0A0D2QHH5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Movement protein binding protein 2C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G268700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF18">
        <property type="entry name" value="PROTEIN OSB1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB58402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0595485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32447" checksum="1007E412F8374B72" modified="2015-04-29" version="1">MIVRRIGALILRRISQLPLPNRNSFHSSVASNRRFSNHFVDDEKEGSAIYRLALKFQRPTTVEVEPPSRNRISLIGTVGEPLNVMNTRSDYFGVQTRLNVKNPYDSDCRFKIRLQMWSEMGKICMEHVKPGDFIYVSGVLGSFSVATLDKQLIIYYKVTVTELSFVTHHGERSTTRECKELESEQDVGEAGMGSYDSQLYLWQVFFTNPFEWWDNRKSKKNPRQPDFKHKDTGEALWLNPNDPPWIKKQLQLLDSKLAEGLGDRESRRYRISEWEYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKA2</accession>
    <name>A0A0D2QKA2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Hexosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_009G211400</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QKA2"/>
    <dbReference type="STRING" id="29730.A0A0D2QKA2"/>
    <dbReference type="Gramene" id="KJB58472">
        <property type="protein sequence ID" value="KJB58472"/>
        <property type="gene ID" value="B456_009G211400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770912"/>
    <dbReference type="eggNOG" id="KOG1950">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VVRSECE"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000018">
        <property type="entry name" value="Hexosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="591" mass="69194" checksum="7E17982612C8588D" modified="2015-04-29" version="1">MGELGLVLQKIIKAAPSKALVIRINLVFLAFFLVIYASLLLRPSSSAYFQNAASLVRCSLRECHHKVEKGVKMEAVLEETEAMKPKRKRNLTMLEVPSFIDEIGGGVKIGMLNFEDEDYSEWEKHGETIPIHFQRVSELFEWKDLFPEWIDEEEEIDGPMCPEIPMPDFSKYDDLDLIVAKLPCEYPVDGWARDVFRLQVHLIVANLAVKKGKRDWNWRTKVVFLSKCRPMLEVFRCNDLVKQEGEWWYYEPEITRLEEKVSLPIGSCNLALPLWGQGNDEVFDVSKIQQATSAAKREAYVTVLHSSESYVCGAITLAQSLLKTGTNRDLILLLDRSITEPKRDALKAAGWQLRFIKRIRNPRAEKGTYNEYNYSKFRLWQMTDYDKVIFIDADILVLKNIDLLFHFPQMTATGNDIWIFNSGIMVVEPSNCTFKLLMNKRKEIFSYNGGDQGFLNEVFVWWHRLPRRVNFLKNFWANSTVETGLKSQLFAADPPKVYSIHYLGLKPWHCYRDYDCNWDIGDQRVYASDVAHQRWWKFYDAMDEKLQQQCGLTERRKIELDWDRKMAEKEGFQDEHWKINITDPRRKFLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QKN3</accession>
    <name>A0A0D2QKN3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2 8">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G143200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5 8">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2 8"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QKN3"/>
    <dbReference type="STRING" id="29730.A0A0D2QKN3"/>
    <dbReference type="Gramene" id="KJB20309">
        <property type="protein sequence ID" value="KJB20309"/>
        <property type="gene ID" value="B456_003G143200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788961"/>
    <dbReference type="eggNOG" id="ENOG502QSR9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QSSHCGI"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102682">
        <property type="term" value="F:cytokinin riboside 5'-monophosphate phosphoribohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000005">
        <property type="entry name" value="CASP-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF65">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB20309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="218" mass="24247" checksum="94CE362A7D71DF74" modified="2015-04-29" version="1">MERDMEMKQSKFKRICVFCGSSPGKKNSYREAAIDLGRELVSRNIDLVYGGGSIGLMGLISQAVFDGGRHVIGVIPKTLMPKEITGETVGEVKAVSDMHQRKAEMARQSDAFIALPGGYGTLEELLEVITWAQLGIHDKPVGLLNVDGYYNSLLSFIDKAVEEGFISPNARHIILSAPTAQDLVKYMEEYEPQHERVAPKLNWEIEQLGYPAKYEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QL25</accession>
    <name>A0A0D2QL25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GDSL esterase/lipase At5g33370-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G004500</name>
        <name evidence="7" type="ORF">Gorai_023791</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0581616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QL25"/>
    <dbReference type="STRING" id="29730.A0A0D2QL25"/>
    <dbReference type="Gramene" id="KJB17536">
        <property type="protein sequence ID" value="KJB17536"/>
        <property type="gene ID" value="B456_003G004500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01837">
        <property type="entry name" value="SGNH_plant_lipase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035669">
        <property type="entry name" value="SGNH_plant_lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF180">
        <property type="entry name" value="OS04G0561800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5036292346" description="GDSL esterase/lipase At5g33370-like" evidence="5">
        <location>
            <begin position="26"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB17536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0581616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39538" checksum="BD7AFC13056E106C" modified="2015-04-29" version="1">MAKTCFHGVFVSIAVTSLLLLQAEAPSPPPPAVYIFGDSTLDVGTNNFIPECAARADFYFNGIDFPYLKPTGRFSNGLNTADQIVRLLGLKKSPPPFLYLVNDPSNFQKNILQGANFASGGSGILRDTGKAKRVIPLEEQIQQFSTIRSNITNMTGSEEATDKILSKAFILISIGSNDMFEYLLDLSKPMSLAEFNATLISTYEYHIKTLYELGARTFGILTVPPIGCTPFARAVFTGNNSCSEPAQAMAVQFYFDVASSLEQFSSTVQDMKYSVGNTFLMTSVLTGDKLAFGLKNIAAACCGNGTYGCNQTASFCSNRDEYLFWDQFHPTQRASELVALTLFGAAEPIMVPMNFSQLLGVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLV1</accession>
    <name>A0A0D2QLV1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription repressor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Ovate family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G016100</name>
        <name evidence="10" type="ORF">Gorai_023891</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional repressor that regulates multiple aspects of plant growth and development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038933">
        <property type="entry name" value="Ovate"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="A_thal_3678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057:SF90">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33057">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR OFP7-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04844">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51754">
        <property type="entry name" value="OVATE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="OVATE" evidence="8">
        <location>
            <begin position="278"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="43"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="180"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="221"/>
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        </location>
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            <begin position="50"/>
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QMQ9</accession>
    <name>A0A0D2QMQ9_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Pectinesterase inhibitor domain-containing protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">B456_009G255900</name>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PLANT INVERTASE/PECTIN METHYLESTERASE INHIBITOR SUPERFAMILY PROTEIN"/>
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    </dbReference>
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        </location>
    </feature>
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        </location>
    </feature>
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            <dbReference type="EMBL" id="KJB59357.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20187" checksum="796C47F5D1671228" modified="2015-04-29" version="1">MAYPNQLCLVLVIFLSIISLSSLPTSAIISKANVSLPIHLSQLVENLCNGKAIQHRRFCLKAVSTPEVITALDTTQLGTLIIKLGAANAKATLNALKALNCCVEAYRYAILSFEMVSSEFVENPQTANYDVAVIGPKIANCEKELINVKVQAPRILAGNRFMKYYVSMGYEITSTLELENPNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQC7</accession>
    <name>A0A0D2QQC7_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">Alpha-L-arabinofuranosidase B arabinose-binding domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G140300</name>
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    <organism evidence="4 5">
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        <lineage>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_001G140300"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036195">
        <property type="entry name" value="AbfB_ABD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012878">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049046">
        <property type="entry name" value="Beta-AFase-like_GH127_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31151:SF0">
        <property type="entry name" value="PROLINE-TRNA LIGASE (DUF1680)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07944">
        <property type="entry name" value="Beta-AFase-like_GH127_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20736">
        <property type="entry name" value="Glyco_hydro127M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110221">
        <property type="entry name" value="AbfB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249981" description="Alpha-L-arabinofuranosidase B arabinose-binding domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 catalytic" evidence="2">
        <location>
            <begin position="111"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Non-reducing end beta-L-arabinofuranosidase-like GH127 middle" evidence="3">
        <location>
            <begin position="506"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB09415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="862" mass="96174" checksum="B04CE8BA089D58C3" modified="2015-04-29" version="1">MKGSTLFQVLAILSVIGSVLSKECTNTPTQLSSHTFRYQLLKSQNETWKQEMFAHYHLIPTDDSAWSDLLPRKILRQEADELSWSMMYKKMKNPGSFKVGGDFLKEISLHDVRLDSDSIQGRAQETNLKYLLMLDVDNLVWSFRKTANLPTPGKPYGGWEAPDVELRGHFVGHYLSATAQMWASTHNDTLKEKMSAVVSALSSCQKKMGTGYLSAFPSELFDRFEAIKPVWAPYYTIHKILAGLLDQYTFANDAQALDMTTWMVEYFYNRVQNVIRTHTVERHWLSLNEETGGMNDVLYRLFAITGNPKHLLLAHLFDKPCFLGLLAVQADDISGFHANTHIPIVIGSQMRYEVTGDPLYKTISTFFMDIVNSSHSYATGGTSVSEFWSDPKRLASTLQTENEESCTTYNMLKVSRHLFRWTKEVAYADYYERALTNGVLGIQRGTEPGVMIYMLPQGRGVSKAVSYHKWGTPFNSFWCCYGTGIESFSKLGDSIYFEEEGSIPSLYIIQYVSSTLDWKSGKIVLNQKVIPVVSSDPYLRVTLTASSKEGSEQLSTLNLRIPIWTSSKGAKATLNAQNLDLPAPGSFLQVKWSGGDKLTLNLPISIRTEQIKDDRPEYASVRAILYGPYLLSGYSNGDWNIKTGSTGSDADWISPVPAAYNNHLVTFSQESGESTFVLTNMNQTIRMEKFPKAGTDAAIRATFRLIFDDTLEKISSIEEAIGKTVMLESFDYPGMVLVQQGTENNLVVTDPPKDTATSSFGIVHGLDGKDNSVSLESVTQKGCYIYSGVNYSSSVGMKLSCNSSSSSSEAGFSQATSFTMNNGLSAYHPISFVAKGGSRNYLMVPLQSVRDESYSVYYNMQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQM4</accession>
    <name>A0A0D2QQM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Embryo defective 1703</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G108400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQM4"/>
    <dbReference type="STRING" id="29730.A0A0D2QQM4"/>
    <dbReference type="Gramene" id="KJB41523">
        <property type="protein sequence ID" value="KJB41523"/>
        <property type="gene ID" value="B456_007G108400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802795"/>
    <dbReference type="eggNOG" id="ENOG502QU8G">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IEMYTVE"/>
    <dbReference type="OrthoDB" id="611606at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34962">
        <property type="entry name" value="EMBRYO DEFECTIVE 1703-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34962:SF1">
        <property type="entry name" value="EMBRYO DEFECTIVE 1703-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB41523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1146" mass="130162" checksum="88CF775FFE1F0A75" modified="2015-04-29" version="1">MELLNPPMSKTPQLFSSFSSFTPRLSIKTSNKKPLRRLHIIPSFPLGLPSRGTNVFRVSAHFSRKTSRRNSLRKKLLDHQKVRENPIPLNPSPDFQNPNGGSENFEKFNSGSTKQIEIDNDTLKSKRLGESVLLSKLENWVDQYKKDAEFWGIGSSPVFTVLQDLEGNVKGVIVHEDEILKRLEFEDMEKVNSKVLYARNLAREMERGENVIPRTSSVAKFVVTGEESGFISGIRGVIHRPGFIPKLSSFGTLVLGGLILLWAVKLFALGKKVVEYTELEKEMMRRKIRSRKGKDILEKGSVEVVQAFEEPPSSSFQRPLLDKQELMNNILKAKAAMDKLAFPDSSGSQSSKSEDFEGEIQEIKLMANEARGIEGREQFVVAKDERECQAANKEFSDEMQPTKEGRKDGASFLSNLSTEDDSEQGEVSYKAVEPISSNEPKDDGVKFLNGVASLDSRVRLVTDASSVQLPKDEQSTNEDLKNTGSTLPVLVKGECNQSPVITDNESYSAKSNAFGKKPRVILSVKEAREFLSTKSNKEKLNQEPVEEAVQKSTPDLILLSDKRSGTSTKQIIHAKDKMFPYGMSRGDSEPTASENACQSAIQGDKESMLKKENDDENSDEECREEAHQQPLSSSQESIGMSREQGQSVMRGNWIENNFHEVEPVLKKIGDGFRENYMVAREKVGEQLNVQAEIKQLGSNEDENELEWMKDDRLRDIVFQVRENELAGRDPFYLMDAEEKLAFFQGLEKKVEKENEKLSHLHEWLHSNIENLDYGTDGISLHDPPEKIIPRWKGPPLEKSPEFLSNFQEQRKALFTGKVGMTYPAKRDGQSFLQKPTESPINEDLAISSSESDLTRKVHDTDKKDPKIVIESSDGSVKPGKKSGKEYWQHTKKWSRGFLECYNAETDPEVKSIMKDMGKDLDRWITEKEVQEAADLMKKLPERNKKFMEKKLNKLKREMELFGPQAVVSKYQEYAEEKEEDYLWWLDLPHVLCIELYTFENEGQRIGFYALEMAADLELEPKPHHVIAFEDTGDCKSFCYIMQAHLDMLGNGRAFIVPQPPKYAFREAKANGFGVTVIKKGELQLNVDQTLEEVEEQICEIGSKMYHDKIMRERSVDISSLMKGMLGVGDKPRRRRSKNKLKKPSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QT58</accession>
    <name>A0A0D2QT58_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G069700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QT58"/>
    <dbReference type="Gramene" id="KJB22849">
        <property type="protein sequence ID" value="KJB22849"/>
        <property type="gene ID" value="B456_004G069700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790610"/>
    <dbReference type="eggNOG" id="KOG2998">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ERNGACH"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF20">
        <property type="entry name" value="ELMO_CED-12 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="71"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="31011" checksum="504B2B36E5E6D9A9" modified="2015-04-29" version="1">MDDRGGSFVAVRRISQGLERGNTCHSTSAEVVAGSTAWLGRGLSCVCAQSRESDARPSFDLTPSQEECLQRLQNRIDIAYDSSIPEHQEALRALWNAAFPEEELRGLISEQWKEMGWQGKDPSTDFRGGGFISLENLLFFATNFPKSFKDLLWKLEGDRSVWEYPFAVAGVNITFMLIQMLDLEAVSFNSTVKPRTMVGAVFLKFLSENESAFDLLYCITFKLMDHQWLAMRASYMDFNTVMKATRRQLERELLLEDITRLEDLPSYSLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R025</accession>
    <name>A0A0D2R025_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G007800</name>
        <name evidence="12" type="ORF">Gorai_006888</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TALE/BELL homeobox family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB63592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R025"/>
    <dbReference type="Gramene" id="KJB63592">
        <property type="protein sequence ID" value="KJB63592"/>
        <property type="gene ID" value="B456_010G007800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772488"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
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    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BEL1-like homeodomain protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
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    </dbReference>
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        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
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    </dbReference>
    <dbReference type="InterPro" id="IPR006563">
        <property type="entry name" value="POX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07526">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00574">
        <property type="entry name" value="POX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0371">Homeobox</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="10">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="281"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB63592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0597072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="526" mass="59294" checksum="0D0587F09F6206BA" modified="2015-04-29" version="1">MATYYPSFTNRRDDLSIQDEKPVPYRASSMGEFTEILSGTSLIPPCSDSLQSVNGRLNITMSAVNCQSQGLSLSLGSEIPPDVSLPSLPCQYQAYSDIYQFQPGFTSTISNSKYLKVVQELLNEVINVQQALRQSDFDKNVSSQLKSSESNESVNNLSKISPTERQELQNKKTKLLSMLDEVDRRYRQYYHQMKILVSSFDSVAGCGAAKPYTSLALQTISRHFRCLRDAISNQIQLTQRSLGEHDNSSNNQGSVIPRLRYVDHQLRQQRALQQFGVMRNAWRPQRGLPESSVSVLRAWLFEHFLHPYPKDSEKIMLAKQTGLTRNQVANWFINARVRLWKPMIEEMYKEEFGEMDSNFKSSLENAAKATGENSSASEDRGEELHENITSKVACADNIQPGQVLYPKPDHIPDVEPNRPTARSMYQNIANPYPNTVIPSNQHGHGTLMTGDTVYDLTELNGFAVGNQVSLALGLRNHENKVFTMSGSTNHKVDSSVGPETVDFRFMEPGNQQDRFGNPHILHDFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9N7</accession>
    <name>A0A0D2R9N7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">adenylyl-sulfate reductase (glutathione)</fullName>
            <ecNumber evidence="18">1.8.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_010G180900</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="16">Reduces sulfate for Cys biosynthesis. Substrate preference is adenosine-5'-phosphosulfate (APS) &gt;&gt; 3'-phosphoadenosine-5'-phosphosulfate (PAPS). Uses glutathione or DTT as source of protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>glutathione disulfide + sulfite + AMP + 2 H(+) = adenosine 5'-phosphosulfate + 2 glutathione</text>
            <dbReference type="Rhea" id="RHEA:14141"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the APS reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.9" evidence="18"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9N7"/>
    <dbReference type="STRING" id="29730.A0A0D2R9N7"/>
    <dbReference type="Gramene" id="KJB67217">
        <property type="protein sequence ID" value="KJB67217"/>
        <property type="gene ID" value="B456_010G180900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0189">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033741">
        <property type="term" value="F:adenylyl-sulfate reductase (glutathione) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009973">
        <property type="term" value="F:adenylyl-sulfate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02993">
        <property type="entry name" value="PDI_a_APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000153">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000252">
        <property type="entry name" value="Phosphoadenosine-phosphosulphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004508">
        <property type="entry name" value="Thioredoxin-indep_APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00424">
        <property type="entry name" value="APS_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482:SF9">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46482">
        <property type="entry name" value="5'-ADENYLYLSULFATE REDUCTASE 3, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="13" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0934">Plastid</keyword>
    <keyword evidence="14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thioredoxin" evidence="20">
        <location>
            <begin position="319"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00050468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00055819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00067033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB67217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="452" mass="50177" checksum="B8A3A0CCF0359D74" modified="2015-04-29" version="1">MAFAVTSSSSSTAISGSSFPRSSASPDLKVPQIGAVRLADRHATVSLSRRRCAVKPVNAEPKRNDSIVPLAATIAAPEISEKVEVEDFEQLAKELDNASPLEIMDKALEKFGNDIAIAFSGAEDVALIEYAKLTGRPFRVFSLDTGRLNPETYRFFNEVEKHYGIRMEYMFPDAVEVQALVRSKGLFSFYEDGHQECCRVRKVRPLRRALKGLRAWITGQRKDQSPGTRSEVPVVQVDPVFEGLDGGIGSLVKWNPVANVDGKDIWNFLRAMNVPANTLHSQGYVSIGCEPCTRPVLPGQHEREGRWWWEDAKAKECGLHKGNLKQDSAAQLNGNGNGASHANGTAKTGIENLARLENRKEPWLVVLYAPWCRFCQEMEESYVELAEKLAGSGVKVAKFRADGEQKEYAKTELQLGSFPTILFFPKHSSKPIKYASEKRDVDSLMAFINALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAT1</accession>
    <name>A0A0D2RAT1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G223500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAT1"/>
    <dbReference type="STRING" id="29730.A0A0D2RAT1"/>
    <dbReference type="Gramene" id="KJB16330">
        <property type="protein sequence ID" value="KJB16330"/>
        <property type="gene ID" value="B456_002G223500"/>
    </dbReference>
    <dbReference type="OMA" id="NTIEPDH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB16330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="108" mass="12622" checksum="7890614BC21384DE" modified="2015-04-29" version="1">MFSFIRFHGVFVYFKAILDTHTYTYILIEWDRNFDLSEDEDKSFVFNDGDPLPFPIQILLQTAPVGFALTNTIEPDHPIVYVNTSIHLDFLYNIAGDEGWIEDKGSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RB78</accession>
    <name>A0A0D2RB78_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Clp ATPase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G265400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">ATP-dependent specificity component of the mitochondrial Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RB78"/>
    <dbReference type="STRING" id="29730.A0A0D2RB78"/>
    <dbReference type="Gramene" id="KJB26906">
        <property type="protein sequence ID" value="KJB26906"/>
        <property type="gene ID" value="B456_004G265400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792745"/>
    <dbReference type="eggNOG" id="KOG0745">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NIGCNRR"/>
    <dbReference type="OrthoDB" id="1721884at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19497">
        <property type="entry name" value="RecA-like_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000002">
        <property type="entry name" value="ATP-dependent Clp protease ATP-binding subunit ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000560">
        <property type="entry name" value="CLP protease regulatory subunit CLPX3 mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050052">
        <property type="entry name" value="ATP-dep_Clp_protease_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003745">
        <property type="entry name" value="PRK05342.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102:SF7">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48102">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="309"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="11">
        <location>
            <begin position="520"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="645"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB26906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="666" mass="71842" checksum="625EF5FD8FEA447D" modified="2015-04-29" version="1">MSGGMWRRWRKLVVMEHLNCLGHWRRIAVGIGGIQHRFSSGGGGDGGGGGGGGDSYDDNNKNDVAAGSNGRTKSRGKARMKSSGTATSALTRRIKAEINCPRCSNHNFFNFNLPDASLDSSDGNSSNGKSTVNFCPTCRTAYHFRPHRIYPLQGTFLEIKSNSKAVPPPPPPPPYPRNGVKTSFWDNLRSENSPPTPPAGNGLAVQTPPGPPFPPGVNFVRADGPKEGHAHGNGTWLGGANLGKDLPTPREICKALDKFVIGQQKAKKVLSVAVYNHYKRIYHSSLEKGSGVEEGSLEALEDNENVELEKSNVLLVGPTGSGKTLLAKTLARFVNVPFVIADATTLTQAGYVGEDVESILYKLLTVAEFNVEAAQQGIVYIDEVDKITKKAERLNISRDVSGEGVQQALLKMLEGTIVNVPEKGARKHPRSDNIQIDTKDILFICSGAFIDLDKTISERQQDSSIGFGAPVRANMRTSWVTNAAVTSSLLESVESSDLIAYGLIPEFIGRFPILVTLSALTEEQLVQVLTEPKNALGKQFKKLFSMNNVKLHFTPKALRLIAKKAMAKNTGARGLRAILESILTEPMYEIPDVKTGHNKVDAVVVDEESVGSTDNPGCGGKILRGDGALKHYFAKTMLKDSIENLSSVEGQSPEAESEVSTRAVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RBR0</accession>
    <name>A0A0D2RBR0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Casein kinase II subunit alpha</fullName>
            <shortName evidence="9">CK II alpha</shortName>
            <ecNumber evidence="9">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G080500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Casein kinases are operationally defined by their preferential utilization of acidic proteins as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="9"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RBR0"/>
    <dbReference type="STRING" id="29730.A0A0D2RBR0"/>
    <dbReference type="Gramene" id="KJB48668">
        <property type="protein sequence ID" value="KJB48668"/>
        <property type="gene ID" value="B456_008G080500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763414"/>
    <dbReference type="eggNOG" id="KOG0668">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NRERVCI"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF56">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="34"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB48668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="333" mass="39321" checksum="7120CEBAE569B242" modified="2015-04-29" version="1">MSKSRVYSDVNVLRPKEYWDYESLTVQWGDQDGYEVIRKVGRGKYSEVFEGKNVNNNERCVIKILKPVEKKKIKREIKILQNLCGGPNIIKLLDIVRDQHSKTPSLVFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSHGIMHRDVKPHNIMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLIDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNNDQLVKIAKVVGTDELNAYLNKYQLELDPQLNALVGRNSRKPWSKFINADNQHLVSLEAIDFLDKLLRYDHQERLTAKEAMVHPYFSQVRASESCRMRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGT9</accession>
    <name>A0A0D2RGT9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Holocarboxylase synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G048500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGT9"/>
    <dbReference type="STRING" id="29730.A0A0D2RGT9"/>
    <dbReference type="Gramene" id="KJB18360">
        <property type="protein sequence ID" value="KJB18360"/>
        <property type="gene ID" value="B456_003G048500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787885"/>
    <dbReference type="eggNOG" id="ENOG502QQY0">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="755598at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016549">
        <property type="entry name" value="UCP009193"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33675:SF9">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33675">
        <property type="entry name" value="NUCLEAR RECEPTOR FAMILY 2 GROUP C PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009193">
        <property type="entry name" value="UCP009193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22996" checksum="2183B8A825B88827" modified="2015-04-29" version="1">MTKKRKSDASRLDEVDRTMYTSFCSAANSLSQLYTQAMNHQRLSFQAGERHALEKLYQWILRQQEEGSRATTVDIVAYLQNELEYGGDEPPMSPRLPLQHPHSQAPMQSNNLGAPVLSNPLSSVNVGQGVRPGDNQVKNSVFSNALSSPVRRSLQPYHLAQGSYNSNNILSSVNGQRNNESNYCHQQNREANSPSSNDCMDMHADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIK0</accession>
    <name>A0A0D2RIK0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_005G101700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIK0"/>
    <dbReference type="STRING" id="29730.A0A0D2RIK0"/>
    <dbReference type="Gramene" id="KJB29451">
        <property type="protein sequence ID" value="KJB29451"/>
        <property type="gene ID" value="B456_005G101700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797317"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000309">
        <property type="entry name" value="E3 ubiquitin-protein ligase MBR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF212">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="645"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="421"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="421"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB29451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="692" mass="75305" checksum="231C4003F4B817D8" modified="2015-04-29" version="1">MQGQRGTVGSLPETIFVHSSTSSNAVAEQQDCWNNIRNPIENRLPDCLLSTNDMNIGYANSMGQEEQLGRWSLVDVNSSGTQNEVSHNEWKTDHRWSSSISASANAGPRLEGRRYEQNSLFAQSSNSDTVSQNLRLNVGFAGVDDNSCQVTERLNLHKPSGSENEQNLLGTGPEAFLLSSGSGRYVVDDNDSRPGCSYEGRRASCKRKALEGNVGQCSSSGSSGYFRSAESSAWHGISASHTAGSNVNISPPSRQVHPRLGLDVRGSASNSIPEQIVLPPTAESSHRNFHLRRNPSSIQEPIAHPIFPTGDMSWQAVVSSAQQPSRLFPANHSLELRSAPVVHNANSENPNIISHVPSLLLNGGSGPRTGSSSNSNPFADRDVPRARHKSRSMARNILHHPMFVPAPELRTLVRNPVLSSGNISSPGNVASTSHAGSNNGANVMSASTWVPHPNPSSQYPRRLSELVRQSLMSSLGTESGGQSNHSSLPSGPTTSPEAMLLSSHVASQVPHRLYPRSLPWLERQDAGFVGIPHSLRTLAAATEGRSRLVVSEIRNVLDLMRRGENLRFEDVMILDQSVLLGVADIHDRHRDMRLDVDNMSYEELLALEERIGNVSTGLSEETILNRLERRKHSSAPGAQLEAEPCCVCQEEYNDGEDIGTLECGHGFHADCIKQWLMHKNLCPICKTTGLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RJ05</accession>
    <name>A0A0D2RJ05_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_005G106800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RJ05"/>
    <dbReference type="Gramene" id="KJB29551">
        <property type="protein sequence ID" value="KJB29551"/>
        <property type="gene ID" value="B456_005G106800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="112" mass="13237" checksum="BAB0FC8DCF8F11E2" modified="2015-04-29" version="1">MRPEILTSLRILFSLFLRRQPPPPASGSPSVATYYPAPALFHTPFWCKTPTYLNASAQEGNVRRKVRRNRNCTYMNVESWPEWSKLLDSEKKPFKQKMTTEKVEYEKKRVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RJA7</accession>
    <name>A0A0D2RJA7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">O-fucosyltransferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_005G113300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase GT106 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RJA7"/>
    <dbReference type="STRING" id="29730.A0A0D2RJA7"/>
    <dbReference type="Gramene" id="KJB29676">
        <property type="protein sequence ID" value="KJB29676"/>
        <property type="gene ID" value="B456_005G113300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRBP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TSCICRT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11299">
        <property type="entry name" value="O-FucT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024709">
        <property type="entry name" value="FucosylTrfase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31818">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31818:SF1">
        <property type="entry name" value="O-FUCOSYLTRANSFERASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009360">
        <property type="entry name" value="UCP009360"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="534"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB29676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="592" mass="67361" checksum="60E6572123A932F2" modified="2015-04-29" version="1">MALPRRRKLHYHRLRSLVQVVSAISGTLLLLFPFLSFLFPSPDESEHFHLRHHQTSFNTVVKDSVSDRNSVFKIPVRAPSLLSTGGKLDRDLWSSKNAKFFYGCSNSSARFAKAEAITHPTRYLAIATSGGLNQQRTGITDAVVAARILNATLVVPKLDQKSFWKDARCQVTVSTSSCPFISFLSKDVKIIKQLPKRGGRTWTPYTMRVPRKCSERCYLNRVLPVLLKRHNAVQLNKFDYRLANRLDTGLQKLRCRVNYHALQFANPILEMGKILVQRLRMRSKHYIALHLRFEPDMLAFSGCDYGGGEKEKNELGAIQKRWKTLHKNNPDKERRQGRCPLAPEEVGLMLRALGYGSDVHIYVASGEVYGGEETLRPLKALFPNFYSKDTIATKEELGPFLSFSSRMAALDFIVCDESDVFVTNNNGNMARILAGRRKYFGHKPTIRPNAKKLYHLFLSRNNMTWEEFSSRIRTLQKGFMGEPKEVRPGRGEFHENPSTCICEDSEAMGKVKADSRHKKHGKLDDSSRKYVMVSDDQNDYDDNDVPEWPDLDEDEDEEDESGSKEKHLSNVTGSDYGAVISDEPELEAMLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKX4</accession>
    <name>A0A0D2RKX4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein RER1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_005G244700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RER1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKX4"/>
    <dbReference type="STRING" id="29730.A0A0D2RKX4"/>
    <dbReference type="Gramene" id="KJB32464">
        <property type="protein sequence ID" value="KJB32464"/>
        <property type="gene ID" value="B456_005G244700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32465">
        <property type="protein sequence ID" value="KJB32465"/>
        <property type="gene ID" value="B456_005G244700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32466">
        <property type="protein sequence ID" value="KJB32466"/>
        <property type="gene ID" value="B456_005G244700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB32467">
        <property type="protein sequence ID" value="KJB32467"/>
        <property type="gene ID" value="B456_005G244700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1688">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF17">
        <property type="entry name" value="PROTEIN RER1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB32464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="194" mass="22247" checksum="8CF6DD0CF9870D41" modified="2015-04-29" version="1">MEGIGGDGASVASPMPQWGHDAWRMYQYYLDKSTPHTTYRWIGTLVIVAIYCLRVYYVQGFYIIAYGLGIYLLNLLIGFLSPLVDPELEGSDGPLLPTKGSDEFKPFIRRLPEFKFWYSMTKAFCIAFIMTFFSVFDVPVFWPILLCYWIVLFVLTMRRQIGHMIKYKYIPFSIGKQKYSGKKGSASSSGSRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RL43</accession>
    <name>A0A0D2RL43_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sialyltransferase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G137400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RL43"/>
    <dbReference type="STRING" id="29730.A0A0D2RL43"/>
    <dbReference type="Gramene" id="KJB30321">
        <property type="protein sequence ID" value="KJB30321"/>
        <property type="gene ID" value="B456_005G137400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794147"/>
    <dbReference type="eggNOG" id="KOG2692">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CIGVIRI"/>
    <dbReference type="OrthoDB" id="10264956at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008373">
        <property type="term" value="F:sialyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd19952">
        <property type="entry name" value="GT29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1480.20:FF:000019">
        <property type="entry name" value="Glycosyl transferase family 29 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1480.20">
        <property type="entry name" value="Glycosyl transferase family 29"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001675">
        <property type="entry name" value="Glyco_trans_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038578">
        <property type="entry name" value="GT29-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044782">
        <property type="entry name" value="SIA1/STLP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47486">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47486:SF1">
        <property type="entry name" value="SIALYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00777">
        <property type="entry name" value="Glyco_transf_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB30321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54994" checksum="B01C9FEA248D8684" modified="2015-04-29" version="1">MRSRSQFQSHKKSTLLPLVCAAAFFSLLLFGIQSSFFSGRINRKIDLGKEKMQVSDLSPQELRSLAEFQTRVQQCVANRGLGLTAHLVDLCKLTLKFPEGTNSTWYNEQFKVFEPLEYHYDICDAILLWEQYRNMTTVLTREYLDARPDGWLDYAAKRIAQLGADKCYNRTLCEEHLNVLLPAKPPFHPRQFRTCAVVGNSGDLLKTEFGKEIDSHDAVIRDNEAPVNEKYAKYVGLKRDFRLVVRGAARNMIKILKGSNDEVLIIKSVTHKDFSDMIKSIPNPVYLFQGIVLRRGAKGTGMKSIELALSMCDIVDIYGFTVDPGYTEWTRYFSTPRKGHNPLQGRAYYQLLECLGVIRIHSPMRAKRKQDWSDVPSREMINRAHAAALHFKRGPDGQLGQFGSCKVWGNVDPDNSGPISGSSDMSDVRKHSNYSKWETMPFKSIRKEAQDHFKQMEGVSMYKIDGNKLDDLVCVRHSVNSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLH4</accession>
    <name>A0A0D2RLH4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3 6">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G144700</name>
        <name evidence="11" type="ORF">Gorai_016748</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3 6"/>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0585992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLH4"/>
    <dbReference type="STRING" id="29730.A0A0D2RLH4"/>
    <dbReference type="Gramene" id="KJB30451">
        <property type="protein sequence ID" value="KJB30451"/>
        <property type="gene ID" value="B456_005G144700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794230"/>
    <dbReference type="eggNOG" id="KOG2666">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMDAWSS"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
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    <dbReference type="FunFam" id="3.40.50.720:FF:000032">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF53">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500133">
        <property type="entry name" value="UDPglc_DH_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="328"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="272"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB30451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0585992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="480" mass="52832" checksum="89929046ACF9817C" modified="2015-04-29" version="1">MVKICCIGAGYVGGPTMAVIALKCPEIQVAVVDISVPRISAWNSDTLPIYEPGLDEVVKKCRGKNLFFSSDVEKHVSEADIVFVSVNTPTKTQGLGAGKAADLTYWESAARMIADVSKSNKIVVEKSTVPVKTAEAIEKILTHNSKGINFQILSNPEFLAEGTAIQDLFEPDRVLVGGRETPEGQKAIKALRDVYAHWVPMDRIICTNLWSAELSKLAANAFLAQRISSVNAMSALCEATGADVSQVSHAVGKDTRIGPKFLNASVGFGGSCFQKDILNLVYICECNGLPEVANYWKQVIKVNDYQKTRFVNRIVSSMFNTVSGKKIAILGFAFKKDTGDTRETPAIDVCKGLLGDKAMLSIYDPQVSEEQIQRDLSMNKFDWDHPVHLQPTSPSSMKQVSVVWDAYAATKDAHGICILTEWDEFKTLDYQKIYDNMQKPAFVFDGRNIVDVAKLREIGFIVYSIGKPLDEWLKDMPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRG2</accession>
    <name>A0A0D2RRG2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CASP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G010900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulates membrane-cell wall junctions and localized cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Casparian strip membrane proteins (CASP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRG2"/>
    <dbReference type="STRING" id="29730.A0A0D2RRG2"/>
    <dbReference type="Gramene" id="KJB21715">
        <property type="protein sequence ID" value="KJB21715"/>
        <property type="gene ID" value="B456_004G010900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790028"/>
    <dbReference type="eggNOG" id="ENOG502RXQU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="753675at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006459">
        <property type="entry name" value="CASP/CASPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006702">
        <property type="entry name" value="CASP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044173">
        <property type="entry name" value="CASPL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01569">
        <property type="entry name" value="A_tha_TIGR01569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488:SF11">
        <property type="entry name" value="CASP-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36488">
        <property type="entry name" value="CASP-LIKE PROTEIN 1U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04535">
        <property type="entry name" value="CASP_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Casparian strip membrane protein" evidence="10">
        <location>
            <begin position="46"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB21715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="209" mass="22445" checksum="047B33BBB5D0A5CF" modified="2015-04-29" version="1">METNKTMRETTINLPETKAEAKEKAPLLNTSKAIAILEPPNRGTKKGIAIGDFVLRLCTIGATLGATVTMGNADAVAPFTTRFLRFEAQFNDIPTFVFFMVANGIVTGYLFLSLPFSTICIVRPLAKAPRILLVIFDTAMTGLTLASASAVAPIVYLAHYGNPNTNWLPFCQQFGDFCSSTSGAMVGSLLAGTLLMTIIILSAFALKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RST1</accession>
    <name>A0A0D2RST1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G035000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RST1"/>
    <dbReference type="STRING" id="29730.A0A0D2RST1"/>
    <dbReference type="Gramene" id="KJB22204">
        <property type="protein sequence ID" value="KJB22204"/>
        <property type="gene ID" value="B456_004G035000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22205">
        <property type="protein sequence ID" value="KJB22205"/>
        <property type="gene ID" value="B456_004G035000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790267"/>
    <dbReference type="eggNOG" id="KOG4830">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GLYTAWM"/>
    <dbReference type="OrthoDB" id="1730117at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000267">
        <property type="entry name" value="AT3g60070/T2O9_50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039672">
        <property type="entry name" value="MFS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11328:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB22205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="453" mass="49986" checksum="3CCE1250DDCFEC17" modified="2015-04-29" version="1">MSNSIEDDSFSKPVGRWSVYCYGVGHMLNDITSACWFTYLLLFLTEIGLSSRDAAIVMLSGQIADGLATIFFGELIDRFGHFKIWHGAGAILVAVSFSSVFGGCIPCKLLSSFSAIVETVSYSTFAAIFNVGWAATQVSHMSMVSCITLNSTSRVVLASCRNAFTMVANLSLYGIAFIVFEVIRAETRADIENQYRWIAYLSIFIGCCFVGVFYLGTKEPRSKTGIHGDIHARISWTYWFLKILYYQVAIVYMLTRLVLNVSQAYLAFYVIDDLQMAQSSKALVPAIIYICSFVVSILLQEIAWKEQRLKAYYTAGGILWIFCGIAIILLPRRMSLFVYAISIFIGIANALMTVTAVSMQNVLIGQDLNGCAFVCGSLSFLDKISCGLTLFVLQSFHSSSPIVAGNYSTGNFSITRYGLGLVPAFCSLVGVAVTWTMELRIPSYKPLTETLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RYY9</accession>
    <name>A0A0D2RYY9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G0665002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYY9"/>
    <dbReference type="STRING" id="29730.A0A0D2RYY9"/>
    <dbReference type="Gramene" id="KJB75977">
        <property type="protein sequence ID" value="KJB75977"/>
        <property type="gene ID" value="B456_012G0665002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1552">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VLIIHVS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="70"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="208" mass="23230" checksum="8F32E2DD18BE1697" modified="2015-04-29" version="1" fragment="single">MGGVTSSMAAKFAFFPPNPPSYKVVTDDLTGLLLLTPFPHRENVEVLKLPTRRGTEIVAIYIRHPMATSTLLYSHGNATDLGQMYELFIELSIHLRVNLMGYDYSGYGQSSGKPSEQSTYADIEAAYKCLEESYGTKQEDIILYGQSVGSGPTLDLAARLPRLRAVVLHSPILSGLRVMYPVKRTYWFDIYKNIDKIPLVNCPVLIIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S048</accession>
    <name>A0A0D2S048_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-locus receptor kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G133900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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    <dbReference type="PANTHER" id="PTHR33595:SF3">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33595">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25821">
        <property type="entry name" value="DUF7950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7950" evidence="1">
        <location>
            <begin position="205"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB58663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0595584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="362" mass="39862" checksum="C5D36F82C837D7BE" modified="2015-04-29" version="1">MIKTLSPYSTTATTAEIMSRYRPIAPKPDVPANSMNESSGMSQKMMQSPYLRSLWCHLQARPTRARKRGRVALSSTTPLKRGRTQVLALSSPSLITSPAKNLSLQGFSHGIPHHSIPNFGGSLDSSSTPPASLMQLPLLPCPPSVPVVANYATILELNCMEPCGGEKLIDLNTIVEIPEEKDLLKQLQGPPASNVIVPQPIRPVGSIIYVGCIKENPILTPQMQVLKKREEVEELVESDALPAVISDSNNKVRLANSAYKEMVGQPECPWLDSVVTGEGRALGNSCKRICGEVVLHLSESDSRLTVKSKGFSCWARIEWGSEGKKRSVKAFCEVIKLSCRSKDYLFTWKFQPYQQEEGRITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHC7</accession>
    <name>A0A0D2SHC7_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G149800</name>
        <name evidence="3" type="ORF">Gorai_016792</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHC7"/>
    <dbReference type="STRING" id="29730.A0A0D2SHC7"/>
    <dbReference type="Gramene" id="KJB30570">
        <property type="protein sequence ID" value="KJB30570"/>
        <property type="gene ID" value="B456_005G149800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794288"/>
    <dbReference type="eggNOG" id="ENOG502SFFC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QDHEKHE"/>
    <dbReference type="OrthoDB" id="1304043at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB30570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="153" mass="16976" checksum="2E6EC01417138626" modified="2015-04-29" version="1">MGNCFTSNKILAENDDLQGCSCNQPNQLIKDMGDVTVSKSEGAADGVKTNNNNMEKKTNKKKKKVVRFNLNEENSGDDRSGKQGESKNGVVRIRLVVTQEELKQILSSKKDLRQSSMEQLIKAVKLRGVRVSEDGRTSDGAWRPALESIPEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHH5</accession>
    <name>A0A0D2SHH5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_007G211800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDI family. ICK/KRP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHH5"/>
    <dbReference type="STRING" id="29730.A0A0D2SHH5"/>
    <dbReference type="Gramene" id="KJB43674">
        <property type="protein sequence ID" value="KJB43674"/>
        <property type="gene ID" value="B456_007G211800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803904"/>
    <dbReference type="eggNOG" id="ENOG502RZHP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HHASASC"/>
    <dbReference type="OrthoDB" id="6373236at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004861">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.365.10">
        <property type="entry name" value="p27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003175">
        <property type="entry name" value="CDI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044898">
        <property type="entry name" value="CDI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044275">
        <property type="entry name" value="KRP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46776">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02234">
        <property type="entry name" value="CDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017811">
        <property type="entry name" value="CDK_inhib_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 5" id="KW-0649">Protein kinase inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-dependent kinase inhibitor" evidence="7">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="116"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB43674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="212" mass="24344" checksum="C4E7AF942401C728" modified="2015-04-29" version="1">MRRKCRKFGEIAVMELSDVGLRTRAMAAATGTVQKKRRRLNGDGDAEFKATSSRASTTSYIQLRSRRILVDHHRLNENRCLSPNLDHDDDVSCCSSNIGSSDKRIIQLPDLEDESMEVETSTHLNFRESRRETTPLSELRAEPEALDSTSRQSEANSRRRSTAEKMPTEAELEEFFAAAEKKVKEQFAEKYNYDIVKDEPLEGRYQWVRLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SL68</accession>
    <name>A0A0D2SL68_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G163100</name>
        <name evidence="5" type="ORF">Gorai_018871</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SL68"/>
    <dbReference type="STRING" id="29730.A0A0D2SL68"/>
    <dbReference type="Gramene" id="KJB42676">
        <property type="protein sequence ID" value="KJB42676"/>
        <property type="gene ID" value="B456_007G163100"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG1426">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION (CELL CYCLE REGULATORY PROTEIN)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
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        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
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        <location>
            <begin position="38"/>
            <end position="93"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="449"/>
        </location>
    </feature>
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            <end position="148"/>
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        <location>
            <begin position="149"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="202"/>
            <end position="295"/>
        </location>
    </feature>
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            <begin position="296"/>
            <end position="343"/>
        </location>
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        <location>
            <begin position="353"/>
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        </location>
    </feature>
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        <location>
            <begin position="403"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0590154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="454" mass="48660" checksum="323F84678EFDC983" modified="2015-04-29" version="1">MLINRLLWKHHQWNKTVVAVSSKALFAQVTTNKPRWMSTVMSFGDGSQGALGLPDSVTGPRGDAYEPTRVLGLPSDITSISAGHYHSLAIDSRGGLWAWGRNQESQLGRDPLAPRDSWNDPKRVEGLDHVNVCAAFASGVISAAIDSNGSVWVWGKSKRGQLGLGKGIIETVVPRRVEALAGEKIVKVSFGWGHALAQTEDGKLLGWGYSADGRIGNVGEALEASPLDSNANISMNDKRFSGSGLDAAELMVLEGMEKEKDMPIIWEPRLVEELQGVEVRDIACGLDHSLVLCRNGTLLSSGSNVYGQLGRTKLDLRLLPVDLTAHPVSIASGLGHSLAICEVPSSDVEGGGMSIFSWGWNQCSQLGREGLENFPSMIEGWEGETPVSVSGGRVHSTALTSHGELWVWGCGKSGRLGLGSSSDEAEPTLLDCLEDFKVLQAVSGFDHNLVLMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNV4</accession>
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            <fullName evidence="8">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">B456_007G3326002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Spermatophyta</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB45849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2SNV4"/>
    <dbReference type="Gramene" id="KJB45849">
        <property type="protein sequence ID" value="KJB45849"/>
        <property type="gene ID" value="B456_007G3326002"/>
    </dbReference>
    <dbReference type="OMA" id="DLDSHVM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
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        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Probable disease resistance protein At1g61300"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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        <property type="entry name" value="NB-ARC"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="InterPro" id="IPR038005">
        <property type="entry name" value="RX-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041118">
        <property type="entry name" value="Rx_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338:SF66">
        <property type="entry name" value="NB-ARC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19338">
        <property type="entry name" value="TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE 13 HOMOLOG"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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            <end position="87"/>
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    </feature>
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            <position position="336"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
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    </evidence>
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            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF18052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB45849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38386" checksum="A3F781AE471607D3" modified="2015-04-29" version="1" fragment="single">MAWAAVTSAVTTIGNLLTQEAIYLWGVEEQVDRLQTELKWMQSSLMEAETKQSTDERIRLWVAEIRELAYDAEDVVEEFALKIGSKNKGGLPSCIKRSACCLKEGWMLHKTRSKIEKIIERINDLVRRLQAYGVKELKNRGEESSSSTERRESRRPYPHIMDDNIVGLVDDTKGLVKVLTNESGCKVVTIWGMGGLGKTTLAKKIYHHRQVIDYFDHLAFVYVSQPCRKRNVWEDILSGFKILDDRKITDEALAEKLCKTLEDKKCLVILDDVWTSEAWDSLKPAFPVATGRDSTSKILLTSRNKGIVSDADIRELKCLNDQQSWELFQKIVFPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SQ27</accession>
    <name>A0A0D2SQ27_GOSRA</name>
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        <recommendedName>
            <fullName evidence="6">AT-hook motif nuclear-localized protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_006G007800</name>
        <name evidence="10" type="ORF">Gorai_000090</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0586951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SQ27"/>
    <dbReference type="SMR" id="A0A0D2SQ27"/>
    <dbReference type="STRING" id="29730.A0A0D2SQ27"/>
    <dbReference type="Gramene" id="KJB33360">
        <property type="protein sequence ID" value="KJB33360"/>
        <property type="gene ID" value="B456_006G007800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797801"/>
    <dbReference type="eggNOG" id="ENOG502QQZB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TGCVMNV"/>
    <dbReference type="OrthoDB" id="780035at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003680">
        <property type="term" value="F:minor groove of adenine-thymine-rich DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.80:FF:000001">
        <property type="entry name" value="AT-hook motif nuclear-localized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.80">
        <property type="entry name" value="Hypothetical protein, similar to alpha- acetolactate decarboxylase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014476">
        <property type="entry name" value="AHL15-29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31100:SF48">
        <property type="entry name" value="AT-HOOK MOTIF NUCLEAR-LOCALIZED PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016021">
        <property type="entry name" value="ESCAROLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117856">
        <property type="entry name" value="AF0104/ALDC/Ptd012-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PPC" evidence="8">
        <location>
            <begin position="68"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR016021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0586951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="256" mass="27271" checksum="0185BF18E3B3274D" modified="2015-04-29" version="1">MGQSTDLRVPMDQIQNQEQDKVNLHKQGIDDAILMATPKGENIRRPRGRPAGSKNKPKPPIIVTRDSANALRAHAMEVTSGCDVHESLASFARRKQRGICVLSGSGFVTNVTLKQPASSGAIVTLHGRYEILSLLGSILPPPAPPGITGLTIYLAGAQGQVVGGGVVGALIASGPVLIMAASFMNATFDRLPLDDADEVATTAAAAMQNQYHHQNGRHHHLDMADLYGMMPQNLITNGTNPPEIYSWAPGRTMSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SXP9</accession>
    <name>A0A0D2SXP9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G005000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7 8">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the snRNP core protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SXP9"/>
    <dbReference type="SMR" id="A0A0D2SXP9"/>
    <dbReference type="STRING" id="29730.A0A0D2SXP9"/>
    <dbReference type="Gramene" id="KJB46886">
        <property type="protein sequence ID" value="KJB46886"/>
        <property type="gene ID" value="B456_008G005000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762619"/>
    <dbReference type="eggNOG" id="KOG3428">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VKMTLRH"/>
    <dbReference type="OrthoDB" id="1665845at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB46886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="12638" checksum="57744825DF8B6C8E" modified="2015-04-29" version="1">MKLVRFLMKLNNETVSIELKNGTVVHGTITGVDISMNTHLKTVKLTLKGKNPVSLDHLSVRGNNIRYYILPDSLNLETLLVEETPRVKPKKPTAGKPLGRGRGRGRGRGRGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1V9</accession>
    <name>A0A0D2T1V9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_011G036600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1V9"/>
    <dbReference type="STRING" id="29730.A0A0D2T1V9"/>
    <dbReference type="Gramene" id="KJB69678">
        <property type="protein sequence ID" value="KJB69678"/>
        <property type="gene ID" value="B456_011G036600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0989">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MARERRW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000013">
        <property type="entry name" value="DNA polymerase III subunit gamma/tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054506">
        <property type="entry name" value="DnaA_N-like_STI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF46">
        <property type="entry name" value="PROTEIN STICHEL-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23007">
        <property type="entry name" value="DnaA_N-like_STI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="479"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="989"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB69678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1163" mass="129159" checksum="61653933A7CD7C67" modified="2015-04-29" version="1">MTRGVSDRILKDANGNISDHLRNHIHLTNCIHLKNHMHKHSPMLADRSLMRDLIVLQRSRSLRDPSASPPSWHSPSVVDLLYKKGDRGAVREGRRSLGAEVQADGRRVSVSSPPLAAMGEASGVNEGVPVTSDRSTKSGARDSRRVRREESGRRSSRTDLIGENKEPVMEQDGNDLAPDAISGNSELKNRKSKKVKGKQTQVVQIKTLSEQLNDVPLDNDDVASSNVCGRHARPEKTPEVAAVHGHSSGLNRVKRRKFRGTRRSRAAPSSREVGVQNELSVASNSFAQGSLHPKYGMEEEENEYDDRNVTRAPRNGCGIPFNWSRIHDRGKTFLDIAGRSFSCGLSDSRLRKGRSGSHGRNAPEMPVESDPSSSSAKSNAEALPLLIEASGSLDSTENARWVNDYSGELGIFADNLLKRNVDSDLASEARFGNQRKLGRNLRSRHQNITQKYMPRTFRDLVGQNLVSQALSNAVMKRKVGLLYVFYGPHGTGKTSCARIFARALNCQSVEQPKPCGVCNSCISHDMGKSRNIREVGPISNFDFESIMDLLDNMIISQLPSQYRVFIFDDCDTLSSDCWSAISKVIDRVPRRVVFILVSSSLDILPHIIVSRCQKFFFPKLKDADIIYSLQWIASREDIEIEKDAVKLIASRSDGSLRDAEMTLEQLSLLGRKISVLLVQELVGLISDEKLVDLLDLALSADTVNTVKSLRVIMETGVEPLALMSQLATVITDILAGSYDFTKERHRRKFFRRQPLSKEDMEKLRQALKTLSEAEKQLRMSNDKLTWLTAALLQLAPDQQYILPISSAGTSSHHSPLPLSDVDRRHDVRKSSRGLSKNARPENLHAGSLGNFETGMVNGIHFDRKRHAASGMAPQQTSIVFTERQNLVKNRNGIEEIWLQVLEKIQVSGLKEFLYSEGKLISVSLGAAPTVQLMFSSPMTKSKAEKFRGHILQAFETVLGSSVTVEIRCEAKKDARAGVGPSQMVMDPESNSRNRMHAGVGSQAQQAGNEIVEIPASPREAKDNEHADNFESNIRGLTLADAATYRKPTLAGRRKLGELSKSQSIVRSKVSLAHVIQQAEGCTQRNGWSKRKAVSIAEKLEQENLRLEPQSKSLLCWKATRVTRRKLSRLKIRTRRPHSLLKFVSCGKCLSSKSPSLLPLPSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T4W9</accession>
    <name>A0A0D2T4W9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G267800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <location>
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            <end position="80"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB38670.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5G4</accession>
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    </protein>
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        <name type="scientific">Gossypium raimondii</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
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    </dbReference>
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        <property type="entry name" value="OSJNBB0038F03.10 PROTEIN"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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    <feature type="domain" description="GATA-type" evidence="10">
        <location>
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        </location>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7H3</accession>
    <name>A0A0D2T7H3_GOSRA</name>
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        <name evidence="3" type="ORF">Gorai_005922</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0599715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T7H3"/>
    <dbReference type="SMR" id="A0A0D2T7H3"/>
    <dbReference type="STRING" id="29730.A0A0D2T7H3"/>
    <dbReference type="Gramene" id="KJB71613">
        <property type="protein sequence ID" value="KJB71613"/>
        <property type="gene ID" value="B456_011G133600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777371"/>
    <dbReference type="eggNOG" id="ENOG502S6TW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRRVFIW"/>
    <dbReference type="OrthoDB" id="785928at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37182">
        <property type="entry name" value="F24J8.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37182:SF2">
        <property type="entry name" value="F24J8.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0599715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="132" mass="14183" checksum="EAF9A3DA90F5F932" modified="2015-04-29" version="1">MAHSLTPVPATSITPIAKSTKLASHIPTLRLQTVSASYQTPHHVLDDKLVHRRTVTLSLAGAMLSLNVGDQRQANAARRPPPPPPEEKKDPSVSGVQAKVLASKKRKEAMKQAMAKMREKGKPVDGTSPPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T7W2</accession>
    <name>A0A0D2T7W2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G141000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2T7W2"/>
    <dbReference type="Gramene" id="KJB71768">
        <property type="protein sequence ID" value="KJB71768"/>
        <property type="gene ID" value="B456_011G141000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S77K">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PNINCHN"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002267710" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB71768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11135" checksum="9B8945FF1366173E" modified="2015-04-29" version="1">MAKSNNNVAMFLNLVLMISFLLIINMAESKLFPSGFIEHGKAKELTPTCVSIYGQQEGDTCFSITQAFNLTLDFFLQINPNLNCDSIFVGEWLCVDGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB71</accession>
    <name>A0A0D2TB71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cationic amino acid transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_008G230700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Gramene" id="KJB51756">
        <property type="protein sequence ID" value="KJB51756"/>
        <property type="gene ID" value="B456_008G230700"/>
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    <dbReference type="KEGG" id="gra:105765056"/>
    <dbReference type="eggNOG" id="KOG1286">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="Proteomes" id="UP000032304">
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    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029485">
        <property type="entry name" value="CAT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243">
        <property type="entry name" value="INNER MEMBRANE TRANSPORTER YGJI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43243:SF3">
        <property type="entry name" value="OS04G0543600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13906">
        <property type="entry name" value="AA_permease_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Cationic amino acid transporter C-terminal" evidence="7">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="572" mass="62728" checksum="7350178D2043971A" modified="2015-04-29" version="1">MATIQSKDNKTIFFNYFKSLSQTPHRLRKRMLATWTPDQELNQVRLRSGADMKRKLKWYDLVALGVGGMLGVGVFVTTGPVARNHSGPSVFISYIIAGISALLSSLCYTEFSVQIPVAGGAFSYLRVTFGEFVGYFAGANILMEYVLSNAAVARSFTEYLCSAFGISDPNSWRVEVPGLLQGYNKLDFSAVALVLILTFCLCHSTKESSILNLIMTAFHIVFFGFIIIMGFCNGSVENLVKPTGLTPNGIRGVLDGAAIVYFSYIGYDSVSTLAEEIQNPPVTLPVGIIGSVFIVSGLYCLMALALCVMVPYNQIAEKASYSMAFQRIGWKWAGNIVGAGASLGIVASLLVAMLGQARYLCVIGRARLVPSWLSKVHPSTGTPLNATLFLGLCTASIALFTDLDIVIEIISIGTLLVFYLVANALIYRKYVLTSKNPPFPTLSFLFLITSCAIGFSISWKLEQQWWGLPLFGGIIMVVTAFFQYTVPCLGPPSEWSVPFMPWPAAVSIFLNVFLMTTLKMLSFQRFAIWGLLITLFYVLYGVHSTFEAEEMGMKMAVNEVPNPSIQLTKLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPE0</accession>
    <name>A0A0D2TPE0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein FAR1-RELATED SEQUENCE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G127000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Putative transcription activator involved in regulating light control of development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the FHY3/FAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2TPE0"/>
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        <property type="protein sequence ID" value="KJB56601"/>
        <property type="gene ID" value="B456_009G127000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768018"/>
    <dbReference type="eggNOG" id="ENOG502QS51">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCYAKQQ"/>
    <dbReference type="OrthoDB" id="1845384at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004330">
        <property type="entry name" value="FAR1_DNA_bnd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031052">
        <property type="entry name" value="FHY3/FAR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669:SF236">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31669">
        <property type="entry name" value="PROTEIN FAR1-RELATED SEQUENCE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03101">
        <property type="entry name" value="FAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="7">
        <location>
            <begin position="553"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB56601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="670" mass="77565" checksum="F65BA1E6BDE18E8B" modified="2015-04-29" version="1">MMDGVSLNTDPVVDDDADADEFEIEGDCGMAKCISQSGVIQGENPLPPVVGMEFDSYEDVYYFYNCYAKEQGFGVRVSNTWYRKTKERYRGKLSCSSAGFKKKSEANRPRPETRTGCPAMIKFRLMENKRWRIIEVELDHNHLISAVSGKFYKSHKQLGIGTKRALHLDSAEEVQKVRLFRTVVIDVEGNGSVEVSSGEFRSSHNQTSQLRLKDGDAQAIHNYFSHLQLIDPNFFYVVDLNEKGCLRNLFWSNTRSRVAYGYFGDVVAVDTICLTDKYQVPLVSFIGVNHHGQSVLLGCGLLAGDTIEACTWLFRAWLTCMLGRPPQVIITDQCRTLQAAVADVFPRAFHCLCLPRIMQKVPEKLGGLYEYESIRMALNNAVYYSLRPEEFEATWEDMIHHYRLRNHVWLQMLYEDRRQWVPVYLKEIFLAGMLLTRPNEVVESFFDGYLDKHTSLKEFLDKYDQALQANHQLEVLADMESRNSGFMLQSRCYFELQLAKLYTNNILRKFEREVEGMYSCFCTRQINGEGEVITYMVREQIEVDGNRRECRDFEVLYNATEMEVLCVCGLFNFKGYLCRHALSVLHQNGIEEIPPQYVVSRWRKDIKRSYVLNHSNGGIDINNPVHRYDHLYKCIMQVVEEGRKSEVRYKDTVQALDQILRKLNLVEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTE1</accession>
    <name>A0A0D2TTE1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G213100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the HSF family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTE1"/>
    <dbReference type="STRING" id="29730.A0A0D2TTE1"/>
    <dbReference type="Gramene" id="KJB58516">
        <property type="protein sequence ID" value="KJB58516"/>
        <property type="gene ID" value="B456_009G213100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0627">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VAINHHH"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000037">
        <property type="entry name" value="Heat stress transcription factor B-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF368">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR B-4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00056">
        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB58516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="360" mass="40017" checksum="5E8DF2734ACBC2A8" modified="2015-04-29" version="1">MALMLDNCEGILLSLDSHKSVPAPFLTKTYQLVDDPATDHIVSWGEDDTTFVVWRPPEFARDLLPNYFKHNNFSSFVRQLNTYGFRKIVPDRWEFANEFFKKGEKHLLCEIHRRKTAQPQVGINHHHHHHHPHSPLVNAPSFFPFPSRVSISPADSDEQANWCDSPPLSSPRGGTGVSVAGGGGGGGYNSSVTALSEDNERLRKSNNLLMSELAHMKKLYNDIIYFVQNHVKPVTPSNSYSPSLLLYGPPSSAAAAPVVNTTTTNSSLLQKPSNQLLGHYPNSQKPRVQVLNSPTATSQSSLTILEEPCSNSCKTKLFGVPLQSKKRLHPEYGATNMETNKARLVLEKDDLRLNLMPPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TV88</accession>
    <name>A0A0D2TV88_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolipid transfer protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G252600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GLTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TV88"/>
    <dbReference type="STRING" id="29730.A0A0D2TV88"/>
    <dbReference type="Gramene" id="KJB59381">
        <property type="protein sequence ID" value="KJB59381"/>
        <property type="gene ID" value="B456_009G252600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771247"/>
    <dbReference type="eggNOG" id="KOG3221">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HYLEDMI"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3520.10:FF:000008">
        <property type="entry name" value="Glycolipid transfer protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF34">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="4">
        <location>
            <begin position="41"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB59381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="224" mass="25478" checksum="C3460C4D14B500A7" modified="2015-04-29" version="1">MKRKREMEGKSEIRSAIEELSMLVKAQPATVGDINLDAAPIPTKPFLHVCTLILQVLDKIGPTMAVLRQDIHQNIQRLENLCESDPTKYLNLIEMLKKEESEGNARKGSSCSKALLWLTRSMDFMVALLQKLVKDPGQNMEQAVEESYNITLKPRHGWISSAAFKVALKLVPDNKTFISLLMAKDQNCDNLKEEMQTLITLLVPFLEQIHSVMRLYRLDRLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TX19</accession>
    <name>A0A0D2TX19_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G291000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TX19"/>
    <dbReference type="Gramene" id="KJB60131">
        <property type="protein sequence ID" value="KJB60131"/>
        <property type="gene ID" value="B456_009G291000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB60131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="83" mass="9472" checksum="0382304B661BB3A7" modified="2015-04-29" version="1">MWVKEKYKLHVCKLWLCGGSVDENGNQYLIIDMHIVPDSVLVLTLFINMLSSVLNLLDLEIAGSFILFSDFKGLSQPSFCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYZ5</accession>
    <name>A0A0D2TYZ5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G073600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TYZ5"/>
    <dbReference type="STRING" id="29730.A0A0D2TYZ5"/>
    <dbReference type="Gramene" id="KJB48520">
        <property type="protein sequence ID" value="KJB48520"/>
        <property type="gene ID" value="B456_008G073600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763346"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PTDNQIW"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000357">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="345"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="612"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="644"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="706"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB48520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="724" mass="79391" checksum="7D7B530279EABE37" modified="2015-04-29" version="1">MRRLQNISFSSSCSSSSSSASSGSSSRKHFEDNINSNQRNQNQRPKSRYHYLGLRISGARLRRQKEPKRLPEQEPPKKEDPQASPLSAGCDTPSLSTSPASKTTSSALAVPLPLPLPLPEGDGEQRFPSPKEVGHSKGLEDRDSEKADESIFLVSSVFACCDSRKTTKNVETVSSSRVLQQEVNKGDSSHDEFMVHFPISSTPTSQFGSPVATLQKMSATDVFPHFMVPTDNQIWSAPEMNALDVAGLPPRAFHDYNAYTTDNTPLHSPNRSPHRKNRSQSGPPSPIHQRLSLESIEISSLRSESNGPISVHPLPLPPGATVASPPASIPQVANKPESLPMNCRWQKGKLIGRGTFGSVYVASNRETGALCAMKEVDIFPDDPKSAECIKQLEQEIKVLSHLKHPNIVQYYGSEIVEDKFYIYLEYVHPGSINKYVRDHCGAITESVVRNFTRHILCGLAYLHSTKTIHRDIKGANLLVDASGVVKLADFGMSKHLSGQRADLSLKGSPYWMAPELMQAVMQKDNSSELALAVDIWSLGCTIIEMFTGKAPWSEYEGAAAMFKVMRDTPPIPETLSPEGRDFLRCCFQRNPAERPSASVLLEHRFVKSSLQSATSSSSSSFNGTKVMDAPLSPGERSEFKLAQSPMQQGLQSAKTVTPDCETAQRSHYKHSELTVAPRYSPRSTLEVPPGLSPSSSGPNTRPPSPSGTTNRSINQECKKNHIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U193</accession>
    <name>A0A0D2U193_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G371800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U193"/>
    <dbReference type="Gramene" id="KJB61636">
        <property type="protein sequence ID" value="KJB61636"/>
        <property type="gene ID" value="B456_009G371800"/>
    </dbReference>
    <dbReference type="OMA" id="HENSQIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35021:SF7">
        <property type="entry name" value="PROTEIN FB17, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="172"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="238" mass="26384" checksum="562A21422EB64C87" modified="2015-04-29" version="1">MNEIQNLQGTAPVNVVDCNDGIAKNQTSSEVETCSNNEAAITEILMKLEADDESRVKFSDFTGLHGERISVGKYSFPPALHPIVNNIIEVYGDGSATSKMNPSIAETVYIMFCASVKEMSNLRLEHVTEDLILKWRDAIKDALRINFKVDFAMEHLKKIACAYIGLMERQKLDGAGLRISKLEAELSTAKEEHAKICEQSKVFIDAAEEFNDKPVSSGFNSDSIGYPQSHIIQLSTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U295</accession>
    <name>A0A0D2U295_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Tryptophan synthase</fullName>
            <ecNumber evidence="3 10">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G161300</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3 10"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U295"/>
    <dbReference type="STRING" id="29730.A0A0D2U295"/>
    <dbReference type="Gramene" id="KJB81788">
        <property type="protein sequence ID" value="KJB81788"/>
        <property type="gene ID" value="B456_013G161300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782565"/>
    <dbReference type="eggNOG" id="KOG1395">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PLTLCQN"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="12">
        <location>
            <begin position="134"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB81788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="477" mass="51686" checksum="9604AD1FE1665A9B" modified="2015-04-29" version="1">MPSNMAATATSTATFRLGNPLSSSSSSSSSVYSSKKLPVNFRKFALQTSPVKSFSVSCTLTRKPVPAAPVSMDSDPNEWQRPDSFGRFGKFGGKYVPETLMSALSELDAAFHSLSKDEKFQEELAGILKDYVGRESPLYFAERLSEHYKRPNGEGPDIYLKREDLNHTGAHKINNAVAQALLAKRLGKKRIIAETGAGQHGVATATVCARFGLQCIIYMGAQDMERQALNVFRMRLLGAEVRAVHSGTATLKDATSEAIRDWVTNVETTHYILGSVAGPHPYPMMVREFHAVIGKETRKQALEKWGGKPDVLVACVGGGSNAMGLFHEFVNDKDVRLIGVEAAGFGVDSGKHAATLTKGDVGVLHGAMSYLLQDEDGQIIEPHSISAGLDYPGVGPEHSFLKDVGRAEYHSVTDEEALEAFKKLSRLEGIIPALETSHALAYLEKLCPTLPNGTKVVVNCSGRGDKDVQTVIKHLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U2I3</accession>
    <name>A0A0D2U2I3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">mRNA cap guanine-N(7) methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">mRNA (guanine-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">mRNA cap methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_013G165200</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="11"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U2I3"/>
    <dbReference type="STRING" id="29730.A0A0D2U2I3"/>
    <dbReference type="Gramene" id="KJB81863">
        <property type="protein sequence ID" value="KJB81863"/>
        <property type="gene ID" value="B456_013G165200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783003"/>
    <dbReference type="eggNOG" id="KOG1975">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LITGDCF"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000127">
        <property type="entry name" value="mRNA cap guanine-N7 methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016899">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189:SF2">
        <property type="entry name" value="MRNA CAP GUANINE-N7 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028762">
        <property type="entry name" value="ABD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 11 13" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="15">
        <location>
            <begin position="61"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="70"/>
            <end position="71"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
        <ligandPart>
            <name>mRNA cap</name>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="site" description="mRNA cap binding" evidence="13">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR028762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028762-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB81863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="372" mass="42492" checksum="5F4CE18FBCAB2E81" modified="2015-04-29" version="1">MKRGYPGSPSSSFGPPQSRSKHNPEGDSQFLEDESTKIFARKVADHYSARTNQTLEEREASPIIHLKKLNNWIKSVLIQLYARRGDAVLDLACGKGGDLIKWDKAKVGYYVGIDIADGSIEDCRTRYNGDADHHQRRKKFTFPARLICGDCFEVRLDRVLADDAPFDICSCQFAMHYSWSTEARARRALANVSALLRPGGTFIGTMPDANVIVKKLREAEGLAFGNSVYWIRFDEEFTDKKFKSSSPFGIKYKFHLEDAVDCPEWIVPFHVFKSLAEEYDLELVFVKNSHEFVHEYMKKPEYIELMRRLGALGDGNQDQSTLSPDEWEAAYLYLAFVLKKRGQPDRTQANSRKDKGQMQIAKEDILYINSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U336</accession>
    <name>A0A0D2U336_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">Exocyst complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G144200</name>
        <name evidence="11" type="ORF">Gorai_009575</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane during regulated or polarized secretion. Involved in polarized cell growth and organ morphogenesis. During cytokinesis, involved in cell plate initiation, cell plate maturation and formation of new primary cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U336"/>
    <dbReference type="STRING" id="29730.A0A0D2U336"/>
    <dbReference type="Gramene" id="KJB49895">
        <property type="protein sequence ID" value="KJB49895"/>
        <property type="gene ID" value="B456_008G144200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764104"/>
    <dbReference type="eggNOG" id="KOG2176">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NINWMAD"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060321">
        <property type="term" value="P:acceptance of pollen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009846">
        <property type="term" value="P:pollen germination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009860">
        <property type="term" value="P:pollen tube growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000002">
        <property type="entry name" value="Exocyst complex component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC15B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="9">
        <location>
            <begin position="58"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="8">
        <location>
            <begin position="420"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00053307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB49895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0592596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="803" mass="90283" checksum="D1F137D9E635A4DE" modified="2015-04-29" version="1">MQSTRSRRKVAPAAADGGDSGDKLEQLLLSSAICNGEDLGPFVRKVFASGRPDTLLHHLRHFARSKESEIEEVCKSHYQDFILAVDDLRSLLSDVDSLKSSLSDSNSRLQSVGGPLLSSLDSFVEAQNASKNVNSALQSVILCIKLTELCLRANLHLSNGSFYMALKCLDSIENEFQDKTPSSTLKRMLERKIPEIRSHIERKISKEFGDWLVDIRVVSRNLGQLAIGQASAARQREEDLRIKQRQAEEQSRLSLRGCVYALEEDDDDGGLGGDENDGYSNGNNGSFGFDLTPLYRAYHIHQTLGLEERFKQYYFENRKLQLTSDFQVSSMTPFLESHQTFFAQIAGFFIIEDRILRTGGGLVSKMEVENLWETAVSKMCSVLEDQFSRMQTANHLLLIKDYVSLLGVTLRRYGYPVDALLNVLSKHRDKYHELLLSDCRKQIAEALAADKFEQMLMKKEYEYSMNVLSFQLQASDIVPAFPYVAPFSSTVPDCCRIVRSFIEDSVSFMSFGGQLDFYDVVKKYLDRLLGEVLDGALLKLISSSVHGVSQAMQVAANMAVLERACDFFFRHAAQLSGIPLRMVERGRKQFPLSKARDAAEDMLSGMLKRKVDGFMTLIENVNWMTDEASQGGNEYVNEVIIYLETLVSTAQQILPPQVLKRVLQDVISHISEKIVGALFGDSVKRFNVNAIMGIDVDIRLLESFADNLSPVFSEGDTNQLKNALAESRQLVNLLLSNHPENFLNPVIREKSYNALDYRKVVTISEKLRDSSDRLFGTFGSRGAKQNPKKKSMDALIKRLKDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U3G8</accession>
    <name>A0A0D2U3G8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G185600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <evidence type="ECO:0000313" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="11483" checksum="041EA35017F94F93" modified="2015-04-29" version="1">MLILILTPIENKDADMKIKSTKRKIIKKATTLSPTATTMQVPMTPSLIFGQASPFYRFIFCAMFTLTLSLIACTKFCHCETTVDSGDNLPTGYNSLSNKIWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>malvids</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB64799"/>
        <property type="gene ID" value="B456_010G065500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2112">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46234">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
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        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB64799.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="146" mass="16212" checksum="F3DC2BC8C972A235" modified="2015-04-29" version="1">MSFTGPSIGSGGRREAHEFGRTHVVRPKGRHQATVVWLHDLGDNGSSWSQLLETLPLPNIKWICPTAPTRPITLFGGFPATAWFDVGELSEDAPDDVEGLEAAAAHVANLLSIEPADSMFPHNFFYNVFIMLFFPFSFTLGLRFFF</sequence>
</entry>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_010G024800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S3K4">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
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        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB63926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="77" mass="8673" checksum="4E9732CAE5032C3A" modified="2015-04-29" version="1">MGGGNGQKSRMAREKHMEKNKPTKGKHLESNKEAMTIQCKVCMQAFICTTSEVKCKEHAEAKHPKSDIFASFPHLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U9A9</accession>
    <name>A0A0D2U9A9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U9A9"/>
    <dbReference type="STRING" id="29730.A0A0D2U9A9"/>
    <dbReference type="Gramene" id="KJB65449">
        <property type="protein sequence ID" value="KJB65449"/>
        <property type="gene ID" value="B456_010G096000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF98">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB65449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="33022" checksum="42042FFCBBEE3D2C" modified="2015-04-29" version="1">MFCVRLNSPSTSVITFEVLGHQLHFSQDPNSKHLGTTVWDTSMVFAKFLEKNCRKGRFCPSKLKGKRVIELGAGCGVAGFGMALLGCDVVSTDQIEVVPLLRRNVERNTSRILQMNSCSDSFGSIKVAELDWGNEDHIKAVGPPFDYVIGTDVVYAEHLVGPLLQTIIALSGPKTTIMLGHEIRSTSVHEQMLLTWKNFFEVKIVSKAKMDSKYQHPSIQLFIMGLKPPPVTADSAVSTEKQEKTDWGIDDQVNETESSSSVDDLLVTRLPDGKLNEWHARRYGSMAARLLRDIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UHN3</accession>
    <name>A0A0D2UHN3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Laccase</fullName>
            <ecNumber evidence="4 13">1.10.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Benzenediol:oxygen oxidoreductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Diphenol oxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Urishiol oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_010G194300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="13">Binds 4 Cu cations per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Secreted</location>
            <location evidence="2 13">Extracellular space</location>
            <location evidence="2 13">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4 13"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UHN3"/>
    <dbReference type="Gramene" id="KJB67511">
        <property type="protein sequence ID" value="KJB67511"/>
        <property type="gene ID" value="B456_010G194300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1263">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NTQHIIT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13849">
        <property type="entry name" value="CuRO_1_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13875">
        <property type="entry name" value="CuRO_2_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13897">
        <property type="entry name" value="CuRO_3_LCC_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000049">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000062">
        <property type="entry name" value="Laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034288">
        <property type="entry name" value="CuRO_1_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034285">
        <property type="entry name" value="CuRO_2_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034289">
        <property type="entry name" value="CuRO_3_LCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017761">
        <property type="entry name" value="Laccase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03389">
        <property type="entry name" value="laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF431">
        <property type="entry name" value="LACCASE-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0052">Apoplast</keyword>
    <keyword evidence="10 13" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112932" description="Laccase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="31"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="157"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="417"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB67511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="568" mass="63188" checksum="253EE6A1217DCAD8" modified="2015-04-29" version="1">MGVFNKFSFIFLVIFLSLSANAEVQRHRFVIQATKVKRLCKTHNTITVNGMFPGPTLEIKNGDTLEVQVVNKARYNVTIHWHGVRQMRTGWADGPEFVTQCPIRPGGSYTYRFTVQGQEGTLWWHAHSSWLRATVYGALIIRPREGKSYPFPKPKRETPILLGEWWDANPIDVVREATRTGAAPNVSDAYTINAQPGDLYKCSSKETTVVSVDSGETNLLRVINAALNQPLFFKVANHKLTVVGADASYTKPFTTSVLMLGPGQTTDVLIRGDQPPSRYYMAARAYQSAQNAPFDNTTTTAILEYKSASCAAKKCNAPTPIMPSLPAYNDTNTVTAFSQSFRSREKAEVPTDIDESLFFTIGLGLNNCPPNFRKRRCQGPNGTRFTASMNNVSFVLPRNFSLLQAHQQGIPGVFTTDFPANPPLKFDYTGNVSRSLFQPVPGTKLYKLKYGSRVQIVLQDTSIVTPENHPIHLHGYDFYIIAEGFGNFDPKRDTSKFNLVDPPMRNTVGVPVNGWAVIRFVADNPGVWIMHCHLDVHINWGLAMAFLVDNGVGELQTIQPPPPDLPIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UJ15</accession>
    <name>A0A0D2UJ15_GOSRA</name>
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            <fullName evidence="11">Zinc transporter</fullName>
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    <gene>
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        <name evidence="8" type="ORF">Gorai_011494</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0594594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UJ15"/>
    <dbReference type="STRING" id="29730.A0A0D2UJ15"/>
    <dbReference type="Gramene" id="KJB55840">
        <property type="protein sequence ID" value="KJB55840"/>
        <property type="gene ID" value="B456_009G097300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EEWGGTH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989196" description="Zinc transporter" evidence="6">
        <location>
            <begin position="30"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB55840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0594594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="36795" checksum="2F298C5A41896FDF" modified="2015-04-29" version="1">MAIISTTAKFMSTSLFIILLLLQFSITKGHGGDDHDENNGDHTNLHDKGLILVKTWCLIILLVTTFAGGVSPYFFRWDESFLLLGTQFAGGVFLATSLIHFLSDSNETFGDLTTKTYPFAFMLASVGYLLTMLGDCIIVSVTSSSKREVRVQVQVEEGRTADDEHSKDVGMDSNNPVFFKTTSFGDTLLLILALCFHSIFEGIAIGVAGTKGDAWRNLWTISLHKIFAAIAMGIALLRMIPKRPFLLTCGYSFAFAVSSPIGVGIGIAIDATTQGHVADWIYAISMGLACGVFIYVAINHLIAKGFKPQAKCYFDTPSFKFLAVLLGVAVIAVVMIWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UKZ6</accession>
    <name>A0A0D2UKZ6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G0842001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB68691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UKZ6"/>
    <dbReference type="STRING" id="29730.A0A0D2UKZ6"/>
    <dbReference type="Gramene" id="KJB68691">
        <property type="protein sequence ID" value="KJB68691"/>
        <property type="gene ID" value="B456_011G0842001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB68691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="114" mass="12899" checksum="DC4A3AE845E41F72" modified="2015-04-29" version="1" fragment="single">MPEEARNRRCKLLLVSLLLVTSYCLKFMVTNLLQRKLFIFLRIEAKLFTVELSSPALVSLFPVLYLPSIPGGVVCKMLKQAIWKVLSKRVVSDSGDKLLLPCLYLPMTSFHAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UM15</accession>
    <name>A0A0D2UM15_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G042200</name>
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    <organism evidence="2 3">
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UM15"/>
    <dbReference type="STRING" id="29730.A0A0D2UM15"/>
    <dbReference type="Gramene" id="KJB69784">
        <property type="protein sequence ID" value="KJB69784"/>
        <property type="gene ID" value="B456_011G042200"/>
    </dbReference>
    <dbReference type="OMA" id="TSSPFRW"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33726">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33726:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB69784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="76" mass="9205" checksum="CA33E20C11CAA6E7" modified="2015-04-29" version="1">MCTTRTKRWMLFKRLMKKELWRWKFLGSAFKWKKMPSLNIHLSFIDDVLFKIASVLEAIFLVSTLCFFYLCCGCHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UUT2</accession>
    <name>A0A0D2UUT2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G271800</name>
        <name evidence="9" type="ORF">Gorai_012816</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UUT2"/>
    <dbReference type="STRING" id="29730.A0A0D2UUT2"/>
    <dbReference type="Gramene" id="KJB59785">
        <property type="protein sequence ID" value="KJB59785"/>
        <property type="gene ID" value="B456_009G271800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770255"/>
    <dbReference type="eggNOG" id="KOG0743">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMDPEMK"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025753">
        <property type="entry name" value="AAA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058017">
        <property type="entry name" value="At3g28540-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14363">
        <property type="entry name" value="AAA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25568">
        <property type="entry name" value="AAA_lid_At3g28540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="244"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB59785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0595967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="442" mass="50190" checksum="9C49687A8C0350AF" modified="2015-04-29" version="1">MWFSTKAMPSYEAILSATASLTASVILLRTIANDFIPESIKDRLFLHLHKISSSLSSQLTVVIEESDGLTANQVFHAANVYLGEKLSSSTPRIKVNKPQKEKRLQVTTDKNQEMVDVFKGVKLKWVLLSTSRNHVLKKNNKNGVLKEEIRYFELSFHKKNREMVLGSYLPYLLQKAKEIKEKNKTLKLHTVDYNGTDYWGSISLDHPASFDTMAMDPTVKTALIEDLDRFSRRREFYRRVGKAWKRGYLLYGPPGTGKSSLVAAMANYLKFDVYDLDLKEIQCNSDLRRLLIGTGNGSIIVIEDIDTSLDSAEDDKVTLSGLLNFIDGLWSSCGDERIIVFTTNHKDRLDPVLLRPGRMDMHLHMSYCTFSGFKTLASNYLRIQDHQLFGEIKGWLDKVQATPAEVAGELMKCEDPNVALRGLIKWFHNRANTEVQDGSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UW12</accession>
    <name>A0A0D2UW12_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_011G204000</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UW12"/>
    <dbReference type="Gramene" id="KJB72856">
        <property type="protein sequence ID" value="KJB72856"/>
        <property type="gene ID" value="B456_011G204000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YRYGAQK"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000248">
        <property type="entry name" value="S-receptor-like kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF30">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 20 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 20 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 21" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="88"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB72856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="396" mass="44918" checksum="E7768B23A9088B46" modified="2015-04-29" version="1">MQKDNKKSVGVVDKEEGPVYLPLIYSYLDYTDIDRLVVTILGDFAKHTGVFFFRRYRYGAQKVEEDHLDNMSGMPTRFSYEELKNFTKNFSNKLGEGGFGFVFHGALSSGSEVAVKHLFGIGPVNKSFIAEVQTIGSIHHFNLVSLVGFCAEKFNRLLVYEFMANGSLDRWIFNKNQDLSLDWQVRKKIILDIAKGLAYLHEDCNRKIIHLDIKPQNILLDENFNAKVSDFGLSKLIEKDQSQVVTSMRGTPGYMAPEWLSSIITEKVDVYSFGIVVLEILCGRRIIDESQQNERYLLELFRRKQEEGQLLDLVDKCNDDMQSNVAEVVEMLKVAAWCLQTEYANRPSMSTLVKHFEGSADAVINVNEDFQNELTTQAPAESFASSITPSVLSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXN5</accession>
    <name>A0A0D2UXN5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pectate lyase</fullName>
            <ecNumber evidence="4 9">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_011G245200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 9"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXN5"/>
    <dbReference type="STRING" id="29730.A0A0D2UXN5"/>
    <dbReference type="Gramene" id="KJB73691">
        <property type="protein sequence ID" value="KJB73691"/>
        <property type="gene ID" value="B456_011G245200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73692">
        <property type="protein sequence ID" value="KJB73692"/>
        <property type="gene ID" value="B456_011G245200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777453"/>
    <dbReference type="eggNOG" id="ENOG502QQEB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LVNNYWD"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF144">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Pectate lyase" evidence="10">
        <location>
            <begin position="31"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB73691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="36576" checksum="1297E46DB61B6FA8" modified="2015-04-29" version="1">MASLPYADVDSTQRAIAGQAEGFGRFAVGGLHGPLVTVTTLSDDGPGSLRDACRNPGPGWIVFKVSGTIRLSTYLSVGSHKTIDGRGERVKLTGKGLRLKECENVIVCNMQFEGGRGHDVDGIQVKPNSKHIWIDRCSFKDYDDGLIDITRGSTDITVSRCYFTQHDKTMLIGADPTHVGDRCIRVTIHHCFFDGTRQRQPRLRFGKVHLYNNYTRNWDIYAVCASVEAQIYSQCNIYEAGKKKKTFEFYTEKAGDREEASSGVIRSEGDLFLNGAQSCLLAAGSGEGSVFHPSEYYKTWTMEAPSDSLKQVLQVCTGWQPVPRLLAHHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UY37</accession>
    <name>A0A0D2UY37_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G341900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UY37"/>
    <dbReference type="STRING" id="29730.A0A0D2UY37"/>
    <dbReference type="Gramene" id="KJB61120">
        <property type="protein sequence ID" value="KJB61120"/>
        <property type="gene ID" value="B456_009G341900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766077"/>
    <dbReference type="eggNOG" id="ENOG502QQ7C">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GYVQAHL"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47215">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47215:SF1">
        <property type="entry name" value="F9L1.8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00410">
        <property type="entry name" value="PHEHYDRXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="1">
        <location>
            <begin position="78"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="332" mass="36100" checksum="78C63030082A01B5" modified="2015-04-29" version="1">MAHFMKRHLISFCTTLAPPPSLVPATVTIFYTLSQVTTETMTVIIPSLPHAHLSAPPLPMSILRRLPFHSLTPCHYRPRRRFATLAAVRQDTTVWTPTPISSIETAAESLFHISIDVSSSPDLAASHTLPGQYLQLRLPDVEKPSFLAIASPPSLAASSGAFEFLVKSVAGSTAELLCGLKKGDVVELSQAMGNGFNIDKIDPPEDYPTVLIFATGSGISPIRSLIESGFGADKRSDVRLYYGARNLRRMAYQDRFKEWESSGVKVVPVLSQPDDSWTGESGYVQAAFSRAKQIHSPKGTGAVLCGQRQMTEEVTSILVADGVSSEKILKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V066</accession>
    <name>A0A0D2V066_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="7">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_012G013100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="7"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V066"/>
    <dbReference type="SMR" id="A0A0D2V066"/>
    <dbReference type="STRING" id="29730.A0A0D2V066"/>
    <dbReference type="Gramene" id="KJB74871">
        <property type="protein sequence ID" value="KJB74871"/>
        <property type="gene ID" value="B456_012G013100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780216"/>
    <dbReference type="eggNOG" id="KOG0813">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYIWLLQ"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000019">
        <property type="entry name" value="Hydroxyacylglutathione hydrolase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005457">
        <property type="entry name" value="Glx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="11"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB74871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="258" mass="28583" checksum="ED6D6410CCE19200" modified="2015-04-29" version="1">MKIFEVPCLEDNYSYLVIDESTKEAAVVDPVEAEKVFDVANQHGVVLKFVLTTHHHWDHAGGNDKIKQLVPGIKVYGGSLDNVRGCTHQLQNGDTLSLGSHLNILALHTPCHTKGHISYYITGKDGEDPAVFTGDTLFIAGCGKFFEGTAEQMYQSLCVTLGSLPKPTRVYCGHEYTVKNLQFASTVEPKNARIQQKLAWANGQRKAGLPTIPSTIEEEMETNPFMRVDLPELQGSIGCQSPVEALREIRQMKDNWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V0E2</accession>
    <name>A0A0D2V0E2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GOST seven transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G015400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB74956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V0E2"/>
    <dbReference type="STRING" id="29730.A0A0D2V0E2"/>
    <dbReference type="Gramene" id="KJB74956">
        <property type="protein sequence ID" value="KJB74956"/>
        <property type="gene ID" value="B456_012G015400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2568">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF76">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 87B-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="7">
        <location>
            <begin position="191"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB74956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="497" mass="56304" checksum="14587547F0D8FE96" modified="2015-04-29" version="1">MMGNNREFICLSYDLIGNGEGLYASKLHVDPDKKPSPEENHLNGKSFIRFESITFRRPKESAEKKNEMQQKTGLVEAIIVEVKDREKIGGSYLHSAAICCTPDLSKEGSCNVGEVIIHQDPNYPYNPQRIQTFFEGKTEETTMVLQTVEINHTGMYYLYFMFCDPELMGTTISGRTVWRNPEGYLPGKMAPLMTYFGLMSLAYLGLGLVWFLWSVQYWKDIIQLQYHITAVIGLGMCEMALWYFEYANFNATGNRPMGITLWAVTFTAVKKTVSRLLLLVVSMGYGVVRPTLGGVIFKVLLLGLTYFVFSEALGLVENLGNIDDLTGKARLFLVLPVSLLDACFIIWIFSALSQTLEKLQIRRSMAKFALYRKFTNSLAISVLLSIAWVGYELYFNAADPLSELWQRAWIIPAFWNLLAFVLLVVICSLWAPSNNPTRYAYSEETGDELEEEGISLTSSSVLLAGESANKQLERKERRASNADLFRLGEEVEEDKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V1D0</accession>
    <name>A0A0D2V1D0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst subunit Exo70 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G422700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the EXO70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V1D0"/>
    <dbReference type="STRING" id="29730.A0A0D2V1D0"/>
    <dbReference type="Gramene" id="KJB62560">
        <property type="protein sequence ID" value="KJB62560"/>
        <property type="gene ID" value="B456_009G422700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768191"/>
    <dbReference type="eggNOG" id="KOG2344">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EAMHYIH"/>
    <dbReference type="OrthoDB" id="1922221at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.170:FF:000003">
        <property type="entry name" value="Exocyst subunit Exo70 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.170">
        <property type="entry name" value="Exocyst complex component Exo70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004140">
        <property type="entry name" value="Exo70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046364">
        <property type="entry name" value="Exo70_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542">
        <property type="entry name" value="EXOCYST COMPLEX PROTEIN EXO70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12542:SF38">
        <property type="entry name" value="EXOCYST SUBUNIT EXO70 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03081">
        <property type="entry name" value="Exo70_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20669">
        <property type="entry name" value="Exo70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex subunit Exo70 C-terminal" evidence="5">
        <location>
            <begin position="237"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU365026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB62560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="630" mass="70790" checksum="E70698ED6107CBBB" modified="2015-04-29" version="1">MKSLCFSPRTASLSISRQSNSPSLSSTARRRFSQSEIEHAIDAAAAIIMKWDAETSAYAGVTSLFHESKREAMQFTKSVNELQDIMHLLVSDQDSGSEKFSQAQRLMQIAMKRLQKEFYQILSTNRADLDPESVSTRSSRTSTSMSDYDDDGLPDDEIRPAGDSITELEDVSSTAMSDLKLIADCMIASGYAKECIRVYKIIRKSIIDEGIYKLGIEKLSSSQVNKMDWDVLDWKIKNWLDAEKISLRTLFKGERILCDHVFSSSDSIKESCFAEISKEGATLLFGFAELVAKAKKSPLEKMFRVLDMYTAISEDWQEIETIFAFESVSAVRLQAINSLVRLSESVLSLLTDFESTIHKDSSKAMTPGSGLHRLTMYSMDYLTLLADYGNILTDIISDWPPPAKSSLPESFFDSPVSDDSPRPAISVRIAWLILVLLCKLDCKSKHYKDVSLSYLFLANNLQHVISRVRASNLMYLLGEEWITKHEAKVRQFAANYERLAWGQVFASLPENPMASMTGGKAKECFMKFTSSFEDAYSKQCSCVVPDLKLRDEIKASIGTKVVAVYREFYDMHKSTVGEESSEKLFVRFSPEDVGNYLSELFFATVSSGSSSTSSSTSSHHHRYMRSLLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V217</accession>
    <name>A0A0D2V217_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_012G050600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V217"/>
    <dbReference type="STRING" id="29730.A0A0D2V217"/>
    <dbReference type="Gramene" id="KJB75661">
        <property type="protein sequence ID" value="KJB75661"/>
        <property type="gene ID" value="B456_012G050600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780969"/>
    <dbReference type="eggNOG" id="KOG0498">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ICVEETE"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.630">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 15-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45651:SF50">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED ION CHANNEL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="12" id="KW-0114">cAMP</keyword>
    <keyword evidence="5" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="4" id="KW-0140">cGMP</keyword>
    <keyword evidence="9" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="398"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="16">
        <location>
            <begin position="505"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB75661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="695" mass="79674" checksum="2BF053C08B5C1325" modified="2015-04-29" version="1">MPSLSNFSSWWTARSHLQITPAESSDNGSGDINEDNLIPNPIECYACTQVGLPVFHSTSCDQAHPPEWEAYAGSSLVPIHARACLQKNSTQAATRQPSGPFGGRRGVLDPRSKRVQKWNRSILLARAMALAIDPLFFYAVSIGRGEWPCLYMDSGLAVTVTVLRTCVDAVHLFHIWLQFRLAYVSRESLVVGCGKLVWDARVIASHYVRSLKGFWFDAFVILPVPQAVFWLVLPKLMREEHIRHIMNILFLSFLFQFLPKVHHTICLMRRMKKVTGYVFGTIWWGFGLNLIAYFIASHVAGGCWYVLTMQRITSCLRQQCARNEQCGKLSLSCGSGSTKVNGKPLCLDVKGPFNYGIYEWALPVVSSNSVAVKILYPIFWGLMTLSTFGNILEPTSNWLEVIFSICLVLAGLLLFTLLIGNIQVFLHAVMAKKRQMQLRCRDMEWWMKRRQLPSCLRQRVRRFEHQNWATLGGEDEMELIKDLPEGLRRDIKRYLCLDLIKKVPLFHNLDDLIFDNICDRVKPLVFSKDEKIFREGDPVQRMVFIVHGRIKRTQSFSKGMVATSIIEAGGFIGDELLSWCLRQSFIDRLPASSATFVSVESVEAFGLDSDHLRYITYHFKYKFASERLKRTARYYSSNWQTWAAVNIQLAWRRYRTRVKGPNPITSRTEQGSSRDHQLLQYASMFMSIKLHDHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4B0</accession>
    <name>A0A0D2V4B0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_012G096200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V4B0"/>
    <dbReference type="STRING" id="29730.A0A0D2V4B0"/>
    <dbReference type="Gramene" id="KJB76554">
        <property type="protein sequence ID" value="KJB76554"/>
        <property type="gene ID" value="B456_012G096200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
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                <person name="Gundlach H."/>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Frelichowski J.E."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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        <location>
            <begin position="23"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB78091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="150" mass="15760" checksum="24EE006C66937745" modified="2015-04-29" version="1">MNEEVAEKPVCPIGLPNISADINLEKTRDAHLVVAALIVTVTFAAAITVPGGFKSEEGSDQGTPYLIHEVAFRTFVVTNALAFSLSLSTLFIHFGMLLPLFPKPLGSITSKLFIVDVILGLALVAMGIAFSTTTYIVLKPSLGLATTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V6P8</accession>
    <name>A0A0D2V6P8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G068000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB64855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V6P8"/>
    <dbReference type="STRING" id="29730.A0A0D2V6P8"/>
    <dbReference type="Gramene" id="KJB64855">
        <property type="protein sequence ID" value="KJB64855"/>
        <property type="gene ID" value="B456_010G068000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S1UC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NFDCAGG"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33881:SF17">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33881">
        <property type="entry name" value="NEUROGENIC LOCUS NOTCH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265905" description="EGF-like domain-containing protein" evidence="1">
        <location>
            <begin position="32"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB64855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22279" checksum="AE0053D1A9BE1648" modified="2015-04-29" version="1">MLFNLTMKLQTNIYAFNCALLLSFIFSSSEAFISNLQPDAVNACAIVNCGKGSCQDTDNSSFGFQCNCYSGWNQFQVGSLIFPPCIVPNCTLNFDCAGGNPSPPTPPEPVFNLSDPCSYTWCGDGSCKTKGSSYQCDCNAGSYNLRNTTTLPCFNPCSLGADCHDLGVGTPPLDHSSSPPGLREIRKVSPIKDGWTLLILGAVFLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VE65</accession>
    <name>A0A0D2VE65_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_010G230500</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VE65"/>
    <dbReference type="STRING" id="29730.A0A0D2VE65"/>
    <dbReference type="Gramene" id="KJB68180">
        <property type="protein sequence ID" value="KJB68180"/>
        <property type="gene ID" value="B456_010G230500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774456"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PIFMEMI"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016679">
        <property type="entry name" value="TF_GATA_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF124">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016992">
        <property type="entry name" value="TF_GATA_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="206"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="134"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB68180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="317" mass="34625" checksum="9DF53EAE0E9EEAA3" modified="2015-04-29" version="1">MEMGDLFVGGYYGGGATGDFSPEKRMSMVEEKLGENFIVDDLLDFSNEDAVIGDGLLFDNVAGNSTDLSTVTCNSSVSGGENHFSSANFTHSSQFSGELGVPYDELAELEWLSNFVEDSFSTVPNLQSNHQIFALPTPESSSSSTRSDSLPRSSTDPIFQHGAPLPGKARSKRSMTAPCDWSTRVLHLNPKPTGHKNRDNPNGNTEYSGRKCLHCASEKTPQWRTGPMGPKTLCNACGVRYKSGRLVPEYRPASSPTFVSTEHSNSHRKVLEIRRQKDMQRGGQGTRFLSQTSVFPISNGGDVADDFLIHHHGGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VFK1</accession>
    <name>A0A0D2VFK1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G159800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
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        <property type="gene ID" value="B456_013G159800"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Reactive Intermediate Deaminase A, chloroplastic"/>
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    </dbReference>
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        <property type="entry name" value="RutC-like"/>
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    </dbReference>
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        <property type="entry name" value="RidA"/>
    </dbReference>
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        <property type="entry name" value="RidA_CS"/>
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    </dbReference>
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        <property type="entry name" value="Rid family detoxifying hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB81489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="192" mass="20360" checksum="33A8B3917FAF799B" modified="2015-04-29" version="1">MAWCSLRSIHVPTVDVGLLRTRSPLAAVGGVVAGSSFLRSSSRNGSPFACLSLSTSPGNKRKTIRIKEAVATDKAPAALGPYSQAIKANNLLFVSGVLGLIPETGKFISDSVEDQTEQVLKNMGEILKASGADYSSVVKTTIMLADLKDFKKVNEIYAKYFPSPAPARSTYQVAALPLDAKIEIECIAALKA</sequence>
</entry>
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        <lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="component" value="Chromosome 12"/>
    </dbReference>
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        <property type="entry name" value="DUF1645 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="270" mass="30911" checksum="C0B95F9DA516DBAC" modified="2015-04-29" version="1">MLDRRYGVAGEQISSFNPAYKIHNDCDGTGDIEFDFWSEREAWYYNSNNLDDVDVDGSEVEFQVEAACDGDSPSPLWGANKVSDASPLLPNNHFYSYLSPTRRRQMIEEGRKELMEMIRNMPESSYELSLKDLVDKQNSSETVKEKVVLEGKSFRLETEIRTKKRTANAKAGSLSRTASMETDKLLLKMFFPSRLSFKKKSMAENSSKVSPSPSCEGSEKPVDKQWWIKKIFIQRDHKNKEDSCKNSSKSRDAKGSSLPGCWPFFFCKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
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    </protein>
    <gene>
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
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                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_012G048100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4683">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SKQCSIN"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012429">
        <property type="entry name" value="HGSNAT_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31061:SF24">
        <property type="entry name" value="LD22376P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07786">
        <property type="entry name" value="HGSNAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Heparan-alpha-glucosaminide N-acetyltransferase catalytic" evidence="2">
        <location>
            <begin position="89"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="53735" checksum="5C924386A39B158C" modified="2015-04-29" version="1">MAIEYEPIKPYADDLEDSVYTQEKHFSIDIDIIGNAEKIQDDDESKNLNQLAFRISDPNIANKGEESPFIPASNSTNLPLHRQQPPQHRLISLDVFRGLTVVLMILVDDVGGILPAINHSPWNGLTLADYVMPFFLFIVGVSLGLTYKRVSCRVTATRKAILRALKLLILGIFLQGGFFHGLNNLTYGMDIQQMRLMGILQRIAIAYLVAALCEIWLKGDDHVTSQLALLRKYQFQLLAASVLTVIYIFLLYGLYVPTWQYQIPDATSSSAPKTFSVKCGVRGDTGPACNVVGMIDRKILGIQHLYRKPVFERTKQCSINSPDYGPLPSDAPAWCQAPFEPEGLLSSVMAMVTCFVGLHYGHIIVHFKDHADRIRLWLIPSSAFLVLGLALDIFGMHINKALYTFSYMCVTAGAAGFLFAGIYLLVDIYGYQRMTLVLEWMGKHALVIYILAACNLIPVVIQGFYWKQPPNNILSLIGIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W4C3</accession>
    <name>A0A0D2W4C3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G092400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="B456_013G092400"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="gene ID" value="B456_013G092400"/>
    </dbReference>
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        <property type="gene ID" value="B456_013G092400"/>
    </dbReference>
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        <property type="component" value="Chromosome 13"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46869">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46869:SF1">
        <property type="entry name" value="C2H2-LIKE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
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        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
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            <begin position="266"/>
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        </location>
    </feature>
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        <location>
            <begin position="356"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB80330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="481" mass="52536" checksum="1C3F649EF1972277" modified="2015-04-29" version="1">MEQNQGKKFVCKFCNKGYPCGKSLGGHIRTHMNTENLGEAEEKAEISTNNKQLLCSRNIKRAAEAEAGGGQSATYDIRENPKKSKRFSDLGNGSVLKEMICKECGKGFQSLKALCGHIACHSDKERVFQKLEDHWGNTEKQKLVVDSQSDTEISTPSRRRRSKRIRCKTGGVYSNNSVSLANGSSSVSEIEEQEQEEVAMCLMMLSRDSGCKKGLNSVADSSDNNSVVLEAKSSSIDLRITVKNANNGGELLKMQKQGVIKLKSAESGPCSENSDSGYFRNGPKKVEPDVSSNGVTNNVECKKLKVKSRSGFEDFDATLGKNRSKFKYVKTEFPKDLVSEVGDNQDDRALTKFGLRSGKNDYSSSPKGTKLESIDDRGEDSLANGSFHAPMAATKLSNGSAEKRLGSKKNKGHVCPFCFRVFKSGQALGGHKRSHFAGGSEDTTLVIKRDSPDMPLPALIDLNLPAPLEEDAMENSGFIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W940</accession>
    <name>A0A0D2W940_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_013G243500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W940"/>
    <dbReference type="STRING" id="29730.A0A0D2W940"/>
    <dbReference type="Gramene" id="KJB83365">
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        <property type="gene ID" value="B456_013G243500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781749"/>
    <dbReference type="eggNOG" id="KOG1091">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000034">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000011">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="23"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="607"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="661"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="714"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="827" mass="92028" checksum="B057926AA72CF92D" modified="2015-04-29" version="1">MSKEIVKEEAPSSSSGVVPAESHPFGSLRGVQWRINLGILPPSSSIDDLRRVTADFRRRYAGLRRQLLVDPHVPKDGATNSLDLVMDNPLSQNPDSTWSQYFRNAELEKMVNQDLSRLYPEHESYFQTPGCQGMLRRILLLWCLRHPDCGYRQGMHELLAPLLYVLHVDVERLLEVRKLYEDLFIDKFDGFSFEENGVAYNFDFKKFADSVEDEIESQGNSKKVMSLYELDPELQAVVLLSDAYGAEGELGIVLSEKFMEHDAYCMFDALMIGAHGSVAMADFFASSPAAESQSGVPPVIEASAALYHLLSIVDSSLHSHLVELGVEPQYFALRWLRVLFGREFSLQDLLVVWDKIFSEDNSPLDEISDDGEHFSFKLLGSRRGTLIAAMAVSMILYLRSSLLATETATSCLQRLLNFPESINLKKLIAKAESLQTLALDSNRSSLPSTFVGAYNCSKSPINAHNVSSDLVCPKTTLNLVPDSYWEEKWRVLHKAEEQRQNSSEKKTSSGKKKWSERVKFRLSRTESEPLPAIREKCKLEHTLSVRRSLLEDLSKQLGLEEDVETGACVEVSNSVDHHPAEVHRDGQNCANKGSICTVEDRCDDGSGAVVSEDNSSIFSEPPSPPSSVINDHDHENDTEKSSVASNLSADDNYVHQRSIPEDLPQPVSLPPEDVYLNSPHENGSSGKMVSAMKEKRQLSGKFQWLHKFRGSIVSEETSDKRGGMSEAANSPNHDSKRNTVDSFTAGASSNSHPTNKGDAMDQNMMDTLKHLGQAMLDHIQVVESVFQQDQGQGGSLDNLSKNIGKGQVTAITALKELRKISNLLSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LYI5</accession>
    <name>A0A0D2LYI5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Acyl-[acyl-carrier-protein] desaturase</fullName>
            <ecNumber evidence="17">1.14.19.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_001G136700</name>
        <name evidence="19" type="ORF">Gorai_021171</name>
    </gene>
    <organism evidence="18 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="19 21" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="19" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="19">8</strain>
            <tissue evidence="19">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Introduction of a cis double bond between carbons of the acyl chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>octadecanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = (9Z)-octadecenoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11776"/>
            <dbReference type="Rhea" id="RHEA-COMP:9656"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:78495"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="1.14.19.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="17">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.-" evidence="17"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LYI5"/>
    <dbReference type="Gramene" id="KJB09367">
        <property type="protein sequence ID" value="KJB09367"/>
        <property type="gene ID" value="B456_001G136700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRJK">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMASTNM"/>
    <dbReference type="OrthoDB" id="937866at2759"/>
    <dbReference type="UniPathway" id="UPA00199"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:stearoyl-[ACP] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000002">
        <property type="entry name" value="Stearoyl-[acyl-carrier-protein] 9-desaturase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005803">
        <property type="entry name" value="FADS-2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="ACYL- ACYL-CARRIER-PROTEIN DESATURASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155:SF9">
        <property type="entry name" value="STEAROYL-[ACYL-CARRIER-PROTEIN] 9-DESATURASE 7, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00574">
        <property type="entry name" value="FATTY_ACID_DESATUR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="14 17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="5 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0934">Plastid</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB09367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="MBA0578900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="395" mass="45031" checksum="56228FD72C605B85" modified="2015-04-29" version="1">MAVNKLMNPITCPSQKLPYVALQHPISSLRLKSPSLFMASTNMKKPLRMADKKVGFQVTHSIPHQKCEVFKSMEMQGWVKNNILPLLKPIERSWQPQELVPDSASDGFEEQVKELRKRAMEIPDDYFVALVGDMITEEALPTYHSILNRLDGVGAATDASTNCWGIWTRGWTAEENRHGDVLNRYLYLSGRVNMSQIEKTVQYLISSGMYVGIENNPYLTFIYTSFQEKATFISHGNTARLALKHGDPLLARICGTVASDEKRHEIAYTKIVEKLFEMDPDGSVIAFAEMMKKKITMPAHLVYDGEDDNLYQHFSAVAQRLGVYTADDYADILEFLVDKWKVKELSELSSEGRKAQEYVCLLAPKIRRLEERAKARSKEAPRIPFSWIFGRQVEL</sequence>
</entry>
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        <name type="scientific">Gossypium raimondii</name>
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    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
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</entry>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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            <end position="227"/>
        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M6Z6"/>
    <dbReference type="STRING" id="29730.A0A0D2M6Z6"/>
    <dbReference type="Gramene" id="KJB13002">
        <property type="protein sequence ID" value="KJB13002"/>
        <property type="gene ID" value="B456_002G050400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787162"/>
    <dbReference type="OMA" id="FCLAMAP"/>
    <dbReference type="OrthoDB" id="935488at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
        <property type="term" value="C:apoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009699">
        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.480.10">
        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044859">
        <property type="entry name" value="Allene_oxi_cyc_Dirigent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004265">
        <property type="entry name" value="Dirigent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21495">
        <property type="entry name" value="NUCLEOPORIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03018">
        <property type="entry name" value="Dirigent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0052">Apoplast</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5008190620" description="Dirigent protein" evidence="4">
        <location>
            <begin position="23"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="191" mass="21155" checksum="862B6F4B010D2AFC" modified="2015-04-29" version="1">MEKQMIFAWAMIFCLAMAPVYGQYYSRTVKAGPRVEKITHLHFYFHDIRSGSNPTAFLIASPNITQDPPSYGTLYAMDDPLTTEFELTSTLVGNAQGLYLALSRDLTKFSAVFYADFTFTTGRFNGSSFSLFSRFPPTDVVPAPGTIREMAIVGGTGKFRMATGFALLRPTSSSNTVGDANVEFNVTLYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MAX1</accession>
    <name>A0A0D2MAX1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G166200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MAX1"/>
    <dbReference type="STRING" id="29730.A0A0D2MAX1"/>
    <dbReference type="Gramene" id="KJB14762">
        <property type="protein sequence ID" value="KJB14762"/>
        <property type="gene ID" value="B456_002G166200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004497">
        <property type="entry name" value="NDHI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47275">
        <property type="entry name" value="NAD(P)H-QUINONE OXIDOREDUCTASE SUBUNIT I, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47275:SF1">
        <property type="entry name" value="NAD(P)H-QUINONE OXIDOREDUCTASE SUBUNIT I, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="120" mass="14203" checksum="147B1EC8FF6D0921" modified="2015-04-29" version="1">MFPMVTRFINYGHQIVRAARYVGQGFMITLSHVNCLPVTIQYPYENLITSEHFRRRIHFEIDKCIACEVCVRVCPIDLPVVGWKFERDIQKNYCLITVLISKFVHFVVIVLSIVQQFFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MWW7</accession>
    <name>A0A0D2MWW7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G114700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MWW7"/>
    <dbReference type="STRING" id="29730.A0A0D2MWW7"/>
    <dbReference type="Gramene" id="KJB23782">
        <property type="protein sequence ID" value="KJB23782"/>
        <property type="gene ID" value="B456_004G114700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791117"/>
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</entry>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </dbReference>
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        <property type="component" value="Chromosome 5"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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            <dbReference type="EMBL" id="KJB29642.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="138" mass="16119" checksum="B39EBCEC73298626" modified="2015-04-29" version="1">MRIHCLKELGKSIMRRPKKNISRFNQLLLLNMLILKIFLLFPPQVRLHREWNKIFRPWNLMELKRILIQLSKVLWGVGVQLTDGILDPDKHSAVIFKENLHSKSREHAVGRKFEALEAGSLRNIERKNSSKVGFGWGG</sequence>
</entry>
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    <accession>A0A0D2NLW8</accession>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Brubaker C.L."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
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                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="gene ID" value="B456_002G121400"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
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        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
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        </location>
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        </location>
    </feature>
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    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="283" mass="31977" checksum="764148787281AB4C" modified="2015-04-29" version="1">MAKEINVTKKALITGLIKPSRIAFTVSGKLKPEDAIQATLSSLPNEVVDTVGVIALPYEDSVSERRRKLEYLEMQEELIKEEEEKEEEELARMKESKARKEDVALKEMNVPTAREAQEHAIVRALEKRDQLCQISCVLAVLALASFVLNMHSVSREREEFLGLVNKEIELYNSMVDKKGTDGEKDAIKAYRVAREETDHSGEVSDSDEVSSVLIEKVDVMLQNLEKEIDDVDAKIGDRWRVPDRDHDGKVTPEEVATTAQYLKDTLGKEGVQDDDNLLIQPWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NMP5</accession>
    <name>A0A0D2NMP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G134600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NMP5"/>
    <dbReference type="STRING" id="29730.A0A0D2NMP5"/>
    <dbReference type="Gramene" id="KJB14628">
        <property type="protein sequence ID" value="KJB14628"/>
        <property type="gene ID" value="B456_002G134600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0BY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RDHCCSN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31729">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31729:SF2">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR RAP2-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="128" mass="14505" checksum="E5AC9A9515596E42" modified="2015-04-29" version="1">MRKWGKWVAEIREPNKRSRIWLGSYSTPIVRDLNSAAARAYDTAVFYLRGPSARLNFPDLILQEDDELKDISPASIRKKATEVGAKVDALHTTSLHHHHASNSSESSNPPQVFSKPDLNKYPETFDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQ17</accession>
    <name>A0A0D2NQ17_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G188800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQ17"/>
    <dbReference type="STRING" id="29730.A0A0D2NQ17"/>
    <dbReference type="Gramene" id="KJB15658">
        <property type="protein sequence ID" value="KJB15658"/>
        <property type="gene ID" value="B456_002G188800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785833"/>
    <dbReference type="eggNOG" id="KOG4155">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEIRTCK"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000775">
        <property type="entry name" value="BnaA09g28200D protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045182">
        <property type="entry name" value="JINGUBANG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844">
        <property type="entry name" value="F-BOX AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22844:SF199">
        <property type="entry name" value="F21J9.19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="236"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB15658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="428" mass="47321" checksum="70C789A333447D37" modified="2015-04-29" version="1">MKVGSCLPTCLTSDDSAVPFPRSPSHSDNRGSSTSSSNSSSDTSYGVLHTNPSLQTLPSVPSLQYLFPETLGFSVSHVTFTSINPRPEHPITCIAVQGNFLYAASINEVNVYDRQTSTLLDVFNSQRSSSGSVKSITFCDGKIFTAHQDCKIRVWQMTMAKKHKFLTALPTVNDRLRRFILPKNYVNERRHVKRLWIEHADAVTGLAVNKCLIYSVSWDKTLKIWRASDMRCLQSIKAHDDAINAVTVSGDATVYTGSADRRIRVWAKRTGEKQYSLMATLEKHKSAVNALALNADGSVLFSGACDRSILVWEREDSSNYMAVTGAMRGHGKAILCLTSVSDLLMSGSTDQTVRIWQRGVEGKYWCLAVLEGHLKPVKSLTAVKDEEESDVIWISSGSLDGEIRTCKVWLSKPSSPLSSTTDILKWTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NRT6</accession>
    <name>A0A0D2NRT6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G131000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NRT6"/>
    <dbReference type="Gramene" id="KJB35862">
        <property type="protein sequence ID" value="KJB35862"/>
        <property type="gene ID" value="B456_006G131000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB35862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="79" mass="9519" checksum="422A27DC43452FFC" modified="2015-04-29" version="1">MRKYITYMFNRQLNHFSYPKSKRLVIILNEIPLKRMRYDVVAKGYCCIICFHAESITLQRSAMIFDFIFGIIVTYLAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NSA5</accession>
    <name>A0A0D2NSA5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G135900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NSA5"/>
    <dbReference type="STRING" id="29730.A0A0D2NSA5"/>
    <dbReference type="Gramene" id="KJB35997">
        <property type="protein sequence ID" value="KJB35997"/>
        <property type="gene ID" value="B456_006G135900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799483"/>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHMAACA"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="17"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB35997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="314" mass="34348" checksum="C4A00CCECDCF6930" modified="2015-04-29" version="1">MSSTQQSSSTKKQTLFIASLIILWYSSNIGVLLLNKFLLSNYGFRFPIFLTMCHMSACAFLSYVSIVFMKLVPLQPIKSRPQFLKIATLSVVFCGSVVGGNISLRYLPVSFNQAVGATTPFFTALFAYFMTFKREAWVTYAALVPVVAGVVIASGGEPGFHWFGFIMCLSATAARAFKSVLQGILLSSEGEKLNSMNLLLYMSPIAVLVLVPAVLIMEPNVLEVILSLGKQHRYMWLLLFINSTMAYSANLSNFLVTKHTSALTLQVLGNAKGAVAVVISILLFRNPVTVVGIGGYTMTVLGVVAYGEAKRRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P4E2</accession>
    <name>A0A0D2P4E2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_007G070300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P4E2"/>
    <dbReference type="STRING" id="29730.A0A0D2P4E2"/>
    <dbReference type="Gramene" id="KJB40587">
        <property type="protein sequence ID" value="KJB40587"/>
        <property type="gene ID" value="B456_007G070300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40588">
        <property type="protein sequence ID" value="KJB40588"/>
        <property type="gene ID" value="B456_007G070300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB40589">
        <property type="protein sequence ID" value="KJB40589"/>
        <property type="gene ID" value="B456_007G070300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802378"/>
    <dbReference type="eggNOG" id="ENOG502QR82">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KFEVAIW"/>
    <dbReference type="OrthoDB" id="1711508at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000257">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase (HAD) superfamily protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="71"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB40587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="290" mass="33184" checksum="D310638B483342AD" modified="2015-04-29" version="1">MEKQQPGSSDVGGKCQTDKLSEEIVLAKSGLVNSISTLTLLDGRNSEEIGDSVYANETNDVSLTIVKTPVSQLRKKLLVLDVNGLLADIIYRSPKNYKADAYIAGRAIFKRPFCDDFLRFCFEKFEVGIWSSRNRRKLERVVDFLMGDMKQKLLFCWDSSYCTTTRFKTLGNRYKPLVFKELRKLWRKSDPNLPWEKGYYNESNTLLIDDSPYKALLNPLGTAIFPHPFKFDMDDDSLGVGGELRVYLERLALAENVQKFLELNPFGQIAITESSHDWGFYSRVIDTCVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PIB4</accession>
    <name>A0A0D2PIB4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_007G329800</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the leguminous lectin family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PIB4"/>
    <dbReference type="STRING" id="29730.A0A0D2PIB4"/>
    <dbReference type="Gramene" id="KJB45807">
        <property type="protein sequence ID" value="KJB45807"/>
        <property type="gene ID" value="B456_007G329800"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QVI9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RVYTFRQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002229">
        <property type="term" value="P:defense response to oomycetes"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000240">
        <property type="entry name" value="Lectin-domain containing receptor kinase A4.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.430:FF:000004">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000039">
        <property type="entry name" value="receptor-like protein kinase FERONIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051824">
        <property type="entry name" value="LRR_Rcpt-Like_S/T_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN DDB_G0281931-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48006:SF81">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="18" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0430">Lectin</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="270"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB45807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="581" mass="64588" checksum="1EBD2FB2F588EC98" modified="2015-04-29" version="1">MSSLHFVHINCGGRITTVNDTTYEADYDQAGPSTFYRSTNWAFSSTGIFLSDDRPDDILVLNNGQVSVDGDEEELYTNARLAPSSLTYYAFCLANATYTVNLHFAEIQFTDDQTYSSLGRRIFDVYIQGKQELKDFNIEEEAGGAGIPIVKKFTVNVSDGTLEIHFRWAGKGTTSMPERSIYGPLISAISVLDPGYKPPSKSGGRISTATMAGIVAGATSATLLIVGIFWWNCCYKLDDEVSGVLFGDEFQNGMELRKFSLVQIAKMTNNFNGEKLGKGGFGVVYKGYLRDSDTYVAVKRISKASKQGIKEYASEVKIISQLRHKNLVKLIGQCHEKGELILVYELMANSSLDSYLFKGKTLLTWEVRFKIVQDLASALFYLHEEGDHCVLHRDIKASNIMLDSSFNAKLGDFGLARLVDHEKASQTTHLAGTLGYLAPECVSSGKASKESDVYSFGVVALEIACGRRSIESKYEESQVPLVAWVWDSYGSQRLLDVADPKLSMNFDAKQMECLLMIGLWCVHPDQHFRPSIRQTIQVLNFEAPWPKLPSTRPTATYNAQITSEIQTSEPCFSDMSIMVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLC8</accession>
    <name>A0A0D2PLC8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">V-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_001G034800</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in the targeting and/or fusion of transport vesicles to their target membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Prevacuolar compartment membrane</location>
            <topology evidence="9">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
            <topology evidence="10">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLC8"/>
    <dbReference type="SMR" id="A0A0D2PLC8"/>
    <dbReference type="STRING" id="29730.A0A0D2PLC8"/>
    <dbReference type="Gramene" id="KJB07639">
        <property type="protein sequence ID" value="KJB07639"/>
        <property type="gene ID" value="B456_001G034800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB07643">
        <property type="protein sequence ID" value="KJB07643"/>
        <property type="gene ID" value="B456_001G034800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771007"/>
    <dbReference type="OMA" id="HYENRIV"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000004">
        <property type="entry name" value="Vesicle-associated membrane protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.50:FF:000008">
        <property type="entry name" value="Vesicle-associated membrane protein 711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF172">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 711-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00417">
        <property type="entry name" value="SYNAPTOBREVIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395320" description="V-SNARE coiled-coil homology domain-containing protein" evidence="13">
        <location>
            <begin position="17"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="14">
        <location>
            <begin position="7"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="15">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB07639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="25213" checksum="934D2EDFF05DCF1B" modified="2015-04-29" version="1">MAILYALVARGSVVLAEFTAASTNASAIARQILEKIPGENDSHVSYSQDRYIFHVKRTDGLTVLCMADESAGRRIPFAFLEDIHQRFVRTYGRAVFSALPYGMNDEFSRVLSQQMEYYSSDPNADRINRLKGEMSQVRNVMIENIDKVLERGDRLELLVDKTANMQGNTFRFRKQTRRFRNTVWWRNVKLTVALIILLLIIIYVVLAFVCHGITLPSCLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLG4</accession>
    <name>A0A0D2PLG4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G049700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLG4"/>
    <dbReference type="STRING" id="29730.A0A0D2PLG4"/>
    <dbReference type="Gramene" id="KJB27918">
        <property type="protein sequence ID" value="KJB27918"/>
        <property type="gene ID" value="B456_005G049700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S0M4">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EKHEHKP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002260794" evidence="2">
        <location>
            <begin position="23"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB27918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="199" mass="22535" checksum="596C7A924EB85166" modified="2015-04-29" version="1">MATTHLLILLLGVVALATPSFGTYESPNYGKPPAPVHNPPKLKPPPYEHKPPVYEPPKKEKPEPKPPVYTPPKKEKPEPKPPVYEPPKKEKPEPKPPVYTPPKKEKHEHKPPVYEPPKKEKPEPKPPVYAPPKKEKPELKPPVYKPPKKPPVYEPKPPKPPVYAPPKKEKPEPKPPVYESPKKPPYGHYPGHPPLEKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLM4</accession>
    <name>A0A0D2PLM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G043600</name>
        <name evidence="12" type="ORF">Gorai_020523</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="12">Leaf</tissue>
        </source>
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    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
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        </source>
    </reference>
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            <location evidence="1">Clathrin-coated vesicle</location>
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        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
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            <location evidence="3">Clathrin-coated pit</location>
        </subcellularLocation>
    </comment>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Single-pass membrane protein</topology>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR33355:SF3">
        <property type="entry name" value="WALL-ASSOCIATED RECEPTOR KINASE GALACTURONAN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="23"/>
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    <feature type="chain" id="PRO_5002265918" description="Wall-associated receptor kinase galacturonan-binding domain-containing protein" evidence="7">
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            <end position="305"/>
        </location>
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            <end position="302"/>
        </location>
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    <feature type="domain" description="Wall-associated receptor kinase galacturonan-binding" evidence="8">
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            <end position="90"/>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="305" mass="32958" checksum="61B2F10D4BEB0893" modified="2015-04-29" version="1">MTLLFMLTVCLSFLALLATPSFATNQANSCRSYCGNITIDYPFSLDYGCGHPGFRDLLFCMNDVLMFHISSGSYRVLDIDYAYQALTLHDPHMSTCHTIILGGRGNGFTVEQWRAPYFNPTPDNVFMLIGCSAESPLFQGFPGKHLPCRNVSGMGCEEYYDCPAWSLIGHKKVGSVYGSGPPECCAVAFEAIKAINLSKLQCEGYSSAYSLAPLRVDGAGGWSYGIRVKYSVQGNDEFCRACEATGGACGFGTDGVKQLCMCGSFNSTTNCDSESSTSSKMTLSLAVALAGSFIYMTTWIMGSQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PN70</accession>
    <name>A0A0D2PN70_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_005G056800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PN70"/>
    <dbReference type="STRING" id="29730.A0A0D2PN70"/>
    <dbReference type="Gramene" id="KJB28583">
        <property type="protein sequence ID" value="KJB28583"/>
        <property type="gene ID" value="B456_005G056800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796804"/>
    <dbReference type="eggNOG" id="KOG2043">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17744">
        <property type="entry name" value="BRCT_MDC1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18432">
        <property type="entry name" value="BRCT_PAXIP1_rpt6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="903"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="531"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="681"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="828"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="732"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="830"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1136" mass="125342" checksum="8BE004318D393903" modified="2015-04-29" version="1">MGSIGDTKGEFKPSDINPSTDFADGETQPFEFDSQFPVSPFCGYRDDNEDDDELNYPQDTVPLDDNNVAVEDGLEIQILNLGEETQVLDFGGETQVLDDLDCCENIETQLLDAFDVSVVLDSEGEGTDGTEVFDDGDEVSDDEVVIGDCGRSIGHEEKESLEQCRASTDECRSSGIHVPTATPDVKAVSEGKPGSVQRFTSVRAASLRASGLAARNAALREMNNESCSNQTDSRFSNQCTVDSKGLNLKVVENISQRQDQNSINFRIGCPTARKLFAEDCFTENKELSRNSEVADAREDLLEAPDCDGPLAGLSYIDSQEPGELSQANALDFVERFVNDKLMELDNEVDFGKSTGGNSKLISCAKGLQSLAKRTIERSTAGEAGNFEWDDFREDEGGGDIYRRMKEEFYGNRSQARKSSTNLRKPKGKKLNESCNVDQPKSGDKRMVHSESKLLLCKLKDNDMTLQEGQMNFRKNLSNEFDEQFNSDSSRGQLEPTGAKTGAAEELNDVGFDTQIAAEAIEALFNGEAATEPKANQGVQSISKGSSKASFRGKAGKRISSTSRKGVSCSDATRFTRQSKRSKLNEDSSVLLEKHSKNVRKESSVTTPVSDSKKGRKRIKEVDFLQESRIGSTDVKLSGMSNANGQLSILHSDQSGEHGNGNGNVKLSIDVHLELISKSIGNHVPSYPRERRSSRKMPVGLGESDKMEAQSRKPAQPDDNGKPTAMQKRSRGNNRSTCIPSSTRRTARSSVNTCPLPYFSDQNSEGKLSRQSLDKQGSDADELNCNFSDKNGRMISKRKIGPKAAKAITHAGGNPDAISLSNAENLTVNVDSDKSPKEKSRSPGSLCTTPTNHLTPINAASPVCMGEEYYKMSCKKNLLKASLIKELRSLCPNEAEPISPLKDMRKRRNLADVRVLFSNHLDEDILKQQKKILARLGIHEASTILDATHFITDKFVRTRNMLEAIASGKSVVSHLWLESIGQVNIHIDEEAYILRDIKKEKELGFCMPVSLARARKRPLLQGRRVLITPKTKPGKETISRLVTAVHGQAIERTGKSSMKDDKIPDDLLVLSCEEDYEICVPFLEKGAAVYSSELLLNGIVTQKLDYQRHRLFEDHVRRTRSTVWMKKDNKFHPVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSI5</accession>
    <name>A0A0D2PSI5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G168900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Plastid</location>
            <location evidence="2">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the major facilitator superfamily. Sodium/anion cotransporter (TC 2.A.1.14) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSI5"/>
    <dbReference type="STRING" id="29730.A0A0D2PSI5"/>
    <dbReference type="Gramene" id="KJB09809">
        <property type="protein sequence ID" value="KJB09809"/>
        <property type="gene ID" value="B456_001G168900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB09810">
        <property type="protein sequence ID" value="KJB09810"/>
        <property type="gene ID" value="B456_001G168900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797011"/>
    <dbReference type="eggNOG" id="KOG2532">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RRTTWGM"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042170">
        <property type="term" value="C:plastid membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17380">
        <property type="entry name" value="MFS_SLC17A9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000058">
        <property type="entry name" value="ascorbate transporter, chloroplastic isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000086">
        <property type="entry name" value="ascorbate transporter, chloroplastic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044777">
        <property type="entry name" value="SLC17A9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF255">
        <property type="entry name" value="ASCORBATE TRANSPORTER, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="453"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="194"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB09809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="601" mass="65750" checksum="C7EDE277783C3317" modified="2015-04-29" version="1">MAIGGLISNRSFGSFIGSGKVCQGEQAILLHKGERSGIAVLHGNMFYRKLWSQTANGFLSGYTCGRYLRSTVHLDENTLKPLSVSPNGRQLISSVSLCHCKKSHKVSPRQRSRGSFGYYSFSSPVPGGCLEPSDKDGIGKNSTSAYYKSEEYDITEAKVDSLPSPDGMNEAILVGGDMQEAVPLWQDFPKRWVIVLLCFAAFLLCNMDRVNMSIAILPMSKEFNWNSATVGLIQSSFFWGYLLTQILGGIWADKIGGKLVLGFGVVWWSVATVLTPIAARFGLPFLLIMRAFMGIGEGVAMPAMNNLLSKWIPVSERSRSLALVYSGMYLGSVIGLAFSPILINKFGWPSVFYSFGSLGSIWFALWLRKAYSSPKEDPELSKEEKKIIMGGSISKEPVTVIPWQLILSKAPVWALIISHFCHNWGTFILLTWMPTYYNQVLKFNLTESGLLCVLPWLTMAAFANIGGWIADTLVSKGLSVTTVRKIMQSIGFLGPAFFLTQLIHVKTPAMAVLCMACSQGSDAFSQSGLYSNHQDIGPRYAGVLLGLSNTAGVLAGVFGTAATGYILQRGSWNDVFKVSVALYIIGTLVWNLFSTGEKVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PTW9</accession>
    <name>A0A0D2PTW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Bifunctional fucokinase/fucose pyrophosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G127000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the GHMP kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PTW9"/>
    <dbReference type="STRING" id="29730.A0A0D2PTW9"/>
    <dbReference type="Gramene" id="KJB49597">
        <property type="protein sequence ID" value="KJB49597"/>
        <property type="gene ID" value="B456_008G127000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763919"/>
    <dbReference type="eggNOG" id="KOG4644">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QRWREAW"/>
    <dbReference type="OrthoDB" id="271303at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050201">
        <property type="term" value="F:fucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047341">
        <property type="term" value="F:fucose-1-phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042352">
        <property type="term" value="P:GDP-L-fucose salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.120:FF:000002">
        <property type="entry name" value="Bifunctional fucokinase/fucose pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012887">
        <property type="entry name" value="GDP_fucose_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052203">
        <property type="entry name" value="GHMP_Kinase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32463:SF0">
        <property type="entry name" value="L-FUCOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07959">
        <property type="entry name" value="Fucose_pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GDP-fucose pyrophosphorylase" evidence="7">
        <location>
            <begin position="119"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="6">
        <location>
            <begin position="810"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="8">
        <location>
            <begin position="967"/>
            <end position="1044"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB49597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116087" checksum="3221A0CC0D224BA2" modified="2015-04-29" version="1">MDPNPQTVLPRTKRKPDITTVLRKSWYHLRLSVRHPSRVPTWDAIVLTAASPEQAQLYDWQLRRAKRMGRIAPSTITLAVPDPEGQRIGSGAATLNAIHALTKHTELVVNGGDGAVGLMGKKHILLLHAGGDSKRVPWANPMGKVFLPLPFLAADNPDGPVPLLFDHILAIASCARQAFKNEGGIFTMTGDVLPCFDASTLILPPDSSTIITVPITLDIAANHGVIVALKSEIFDESYTVSLVDNLLQKPSVDELVKNQAILDDGRALLDTGIIAVRGNAWVELVKLACSCQPLISELLKSKKEMSLYEDLVAAWVPTKHDWLQHRPLGEALVNKLGKQRMFSYCAYDFLFLHFGTSSEVLDHLSASDSALVGRRHLCSIPATTVSDIAASSVVLSCKIADGVSIGEDSLIYDSNISSGIQIGSQSIVVGMNVPKDSDNMAGNSIKFMLPDRHCLWEVPLVGCTERVIVFCGIHDNPKNPLKKDGTFCGKPWEKVMHDLGIEENNLWSSSSSQEKCLWNAKLFPILSYFEMLRVGMWLMGLSDGKNLHYLPLWRNSPRVSLEELHRSIDFSKMCTGSSNHQADLAAGIAKACINYGMLGRDLSQLCEEILQKETSGVEICKDFLALCPKLIEQNSKILPKSRAYQVQVDLLRACGEETKAYQLEHEVWASVADETASAVRYGFGEHLLESSGSKSTLAFRNNNHVSSMDKPFCPKTVKVELPVRVDFVGGWSDTPPWSLERAGCVLNMAVSLEGSLPIGTVVETTNSNGVLIIDDSGKELHIKELASIAPPFDGDDPFRLVKSALLVTGIIRENILVSNGLRIRTWANVPRGSGLGTSSILAAAVVKGLLQIIDGDDDNENVARLVLVLEQLMGTGGGWQDQIGGLYPGIKYTRSYPGIPLRLQVFPLVASSQLISKLQERLLVVFTGQVRLAHQVLQKVVLRYLRRDNLLVSSIKRLTELAKIGREALMNCDVDKLGEIMLEAWRLHQELDPYCSNEYVDKLFAFADPYCSGYKLVGAGGGGFALLLAKNATCAKELRSMLGKNPEFDSVIYNWTIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PVL8</accession>
    <name>A0A0D2PVL8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G154800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q8H4"/>
    <dbReference type="SMR" id="A0A0D2Q8H4"/>
    <dbReference type="STRING" id="29730.A0A0D2Q8H4"/>
    <dbReference type="Gramene" id="KJB35613">
        <property type="protein sequence ID" value="KJB35613"/>
        <property type="gene ID" value="B456_006G121500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799318"/>
    <dbReference type="eggNOG" id="KOG1464">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000011">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058796">
        <property type="entry name" value="COPS2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25983">
        <property type="entry name" value="COPS2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="243"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB35613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="439" mass="51421" checksum="3CA17C3110289665" modified="2015-04-29" version="1">MASDADMEDYGFEYSDEEPEEQDVDIENQYYNSKGLVETDPEGALAGFAEVVSMEPEKAEWGFKALKQTVKLYYRLGRYKEMMEAYREMLTYIKSAVTRNYSEKCINNIMDFVSGSASQNFGLLQEFYQTTLKALEEAKNERLWFKTNLKLCKIWFDMGEYGRMSKILKELHKSCQKEDGTDDQKKGSQLLEVYAIEIQMYTETKNNKKLKQLYQKALAVKSAIPHPRIMGIIRECGGKMHMAERQWAEAATDFFEAFKNYDEAGNQRRIQCLKYLVLANMLMESEVNPFDGQEAKPYKNDPEILAMTNLIAAYQRNEIIEFEKILKSNRRTIMDDPFIRNYIEDLLKNVRTQVLLKLIKPYTRIRIPFISKELNVPEKDVEQLLVSLILDNRIDGHIDQVNRLLERGNRSKGMKKYTAIDKWNTQLRSLYQTVNNRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QBY6</accession>
    <name>A0A0D2QBY6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G086100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QBY6"/>
    <dbReference type="Gramene" id="KJB55632">
        <property type="protein sequence ID" value="KJB55632"/>
        <property type="gene ID" value="B456_009G086100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB55632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="111" mass="12505" checksum="1143BC57F42EB2D3" modified="2015-04-29" version="1">MSYRFFFRKTFSEKHSFNLSFPLHPSTSASPPHQCASSSWVINRFIESFIAKHVQGRGFVPAMPAPRPAGIGTSKPGFGTNVSSPPESWRFPPIVLPTWRPLLIEWGCQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QEB1</accession>
    <name>A0A0D2QEB1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_009G122000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. AP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QEB1"/>
    <dbReference type="STRING" id="29730.A0A0D2QEB1"/>
    <dbReference type="Gramene" id="KJB56447">
        <property type="protein sequence ID" value="KJB56447"/>
        <property type="gene ID" value="B456_009G122000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770840"/>
    <dbReference type="OrthoDB" id="207175at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000002">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000004">
        <property type="entry name" value="AP2-like ethylene-responsive transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467">
        <property type="entry name" value="AP2-LIKE ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32467:SF122">
        <property type="entry name" value="AP2-TYPE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="44"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="10">
        <location>
            <begin position="146"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB56447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="354" mass="39955" checksum="6E81545F763387F9" modified="2015-04-29" version="1">MAKISHQNQKNGSGNEKTAAQPTTKLKRTRKTVPRHSPPQRSSTYRGVTRHRWTGRFEAHLWDKNCWNESQKKKGRQVYLGAYADEEAAAHAYDLAALKYWGQDTVLNFPLATYEKELKEMESQSKEEYIGSLRRKSSGFARGVSKYRGVARHHHNGRWEARIGRVFGNKYLYLGTYATQEEAAMAYDMAAIEYRGLNAVTNFDLSRYIGWLHPNDQSDSNNSSNPQQNFNGDTNSTPSPNHDTKLEISIQSQTYCTSDTRLDDSNSNGSSSSASSALGHLLKSSKIKEMLDRTSEAACPSTPPEPNVPRRSFPDYIQTYFDCQDSSSYTEDDDIIFGDLDSLAIPMFHCELDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGP7</accession>
    <name>A0A0D2QGP7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G023400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGP7"/>
    <dbReference type="Gramene" id="KJB06480">
        <property type="protein sequence ID" value="KJB06480"/>
        <property type="gene ID" value="B456_001G023400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB06480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="66" mass="7651" checksum="9A549CC9FE0A308B" modified="2015-04-29" version="1">MDISSKFDLKGELLPLLHHPKTNTNQRQFCGVTERIVRNLITIIIINKLKLRNVLNLYSLNSTITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QGV5</accession>
    <name>A0A0D2QGV5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G073200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QGV5"/>
    <dbReference type="Gramene" id="KJB18869">
        <property type="protein sequence ID" value="KJB18869"/>
        <property type="gene ID" value="B456_003G073200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788147"/>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="273089at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214:SF16">
        <property type="entry name" value="OS10G0481450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214">
        <property type="entry name" value="ZINC FINGER, RING-CH-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB18869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="311" mass="33829" checksum="3470DCCD195C7426" modified="2015-04-29" version="1">MRVLGEFPDLNILEPKGGVVNAVNNNQMQNGGSNEASSRAGGLSGNLHEPDLEMHGNIPLPQEEIQPGSVGDSACEANPTSATNVVTKAESHLAQQPIAKLSKDAESTKEDLPHAASPKMGYFSRTTSAHEQCRVCQQEKEEGLIDLGCQCKGGLAKAHQSCIVTWFHTKGSNKCEICQVVAVNVTAPQPERSRNYWVWRINPRLVALNRERGCFSPLWLALSILIGGLLLDMLISLTLGVSALPVNLVIVVIVVIGLGTALRLAVEFYHEWSTRRALQRVETNATIGYHTTLVLFWEGNPMFVTAQICTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QIT4</accession>
    <name>A0A0D2QIT4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G250300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="protein sequence ID" value="KJB16841.1"/>
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        <property type="gene ID" value="B456_002G250300"/>
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    <dbReference type="KEGG" id="gra:105786438"/>
    <dbReference type="eggNOG" id="ENOG502QR5K">
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045882">
        <property type="entry name" value="GPT1/2"/>
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        <property type="entry name" value="OS05G0121800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="OS12G0102700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="177"/>
            <end position="200"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="355"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="520"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="40"/>
            <end position="49"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="541"/>
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    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB16841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="770" mass="81262" checksum="CCCFF358AF83BF18" modified="2015-04-29" version="1">MVDSEKQSDFNMKGLSLIDVSSEDDSLINSPLADPINLKSSEKGSETKTVRFAVDPESVEMAVGSIEEAGKVKEPSESSEQEKTSKNGKYNLRKSLAWDSAFFTSEGFLEPEELSSMLGGNEKGQLQALPGIQEDVNKSYDSLTTLDSETLTLESLEADLFEDVRASIQKSNKVSVTANSSGKKELKTTDTKTVSSSKKVELPTQDKKIQIKQKATPKKPNVGVKDSGKTVKQVVVHPQISQTVWSVARAGESTSSLLKPPKVLSGVGHTPTKRASLGAKNVKMDKDAKTVTGRGTTVLKTPALGGSRNIVPRPKLSSKSSSCSPASSKTELTSSCSSLESCASFSSNRTNKSSLNLIKHKNGPRIVNPSSGSTISARSKIAPKGKIQAGSSKPPTCLKSSTKFSSSISPTSSISEWSSESSSSISATNRSSNVVRDSLGTGSRKGLTTKRDAHQVLDSQNLPTGSEGDDTEVNGSLDESENKVSAGTSRLLHPGSVKPSGLRMPSPKLGFFDGVRSSGHTPNGSMLSHSGVTSGLPKIGTKSTSQSGNSNKAKIGKLQPVRSLTVIQSPKVDVKQTSSAVKSRSSLSIQKSPVAATKVPSSLRNLKTCPGISPKLQSTSCPRTSRESYSKAQGIGSAGKVEIVPLDGVTESTADIASKTDVQNTIASEAENKTYSYPCFKKEEAPVEDRIVAVQKEPIADFENSMSNPTPTSPSPMISEVTCGSRIPFSVKDSFCNTDASLDVLSGSTVAAEKTTVLPLSESTLPENNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJD5</accession>
    <name>A0A0D2QJD5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Purple acid phosphatase</fullName>
            <ecNumber evidence="11">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G197600</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QJD5"/>
    <dbReference type="Gramene" id="KJB58167">
        <property type="protein sequence ID" value="KJB58167"/>
        <property type="gene ID" value="B456_009G197600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768998"/>
    <dbReference type="eggNOG" id="KOG1378">
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    </dbReference>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.380:FF:000001">
        <property type="entry name" value="Fe(3+)-Zn(2+) purple acid phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000034">
        <property type="entry name" value="Fe(3+)-Zn(2+) purple acid phosphatase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
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    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
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    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF35">
        <property type="entry name" value="FE(3+)-ZN(2+) PURPLE ACID PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112713" description="Purple acid phosphatase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="12">
        <location>
            <begin position="60"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="474" mass="54091" checksum="D2E4E4D455E175C8" modified="2015-04-29" version="1">MVAARWNCFSFQLVFAISFIFSIAEVCNGGRTSSFVRNSDLSRDMPLDSDVFRVPPGYNAPQQVHITQGDHLGNAVIVSWVTPDEPGSNSVFYWAENSELKNSAQGIVLTYKYFNYTSGFIHHCTVRDLEFDTKYYYEVGIGNSSRRFWFVTPPAIGPDVPYTFGLIGDLGQTHDSNSTLTHYELNPAKGQTLLFLGDLSYADAYPFHDNARWDTWGRFIERNAAYQPWIWTAGNHEIDVVPAIREAIPFKPYTHRYHVPYTASGSTSPLWYSIKRASTYIIVLSSYSAYGTSTPQYKWLERELPKVNRTETPWLIVLMHSPFYNSYVHHYMEGESMRVMFEPWFVEYKVDVVFAGHVHAYERSERISNIAYNIANGLCTPIKDPSAPVYLTIGDGGNLEGLVTEMTEPQPNYSAYREASFGHGILEIKNRTHAYFGWHRNQDGYAVEADSLWLHNRYWSVSDSEELSVATATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJI6</accession>
    <name>A0A0D2QJI6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor TT2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G020500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB07405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJI6"/>
    <dbReference type="Gramene" id="KJB07405">
        <property type="protein sequence ID" value="KJB07405"/>
        <property type="gene ID" value="B456_001G020500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801103"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASIKYPR"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB8-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47999:SF96">
        <property type="entry name" value="TRANSCRIPTION REPRESSOR MYB6-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB07405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33321" checksum="777822AEAED305AA" modified="2015-04-29" version="1">MDLYKQRERVGEIRSMGKSSCCSKEGLKKGAWTDWEDKILASYINVHGEGKWRNLPKRAGLKRCCRSCRLRWVNYLRPDIKRGNISHDEEELIIRLHNLLGNRWSLIAGRLPGRTDNEIKNYWNSTLSKRTKAQASIKYPRSSNFTHKTIPIESKLKESSKRSAIQTKAIGGSSKVMVPTQPPTSQDIDKLRDGKLYSTNNSQEMGGDIATVEAHNGTQVLDSLNSDGGSDLLSFEINELRKASDGNFEENRMQLLPFDEAMFEDWTTYPYLNDNAATGWDSLAFLIDSNDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QRG9</accession>
    <name>A0A0D2QRG9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_004G040100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QRG9"/>
    <dbReference type="STRING" id="29730.A0A0D2QRG9"/>
    <dbReference type="Gramene" id="KJB22309">
        <property type="protein sequence ID" value="KJB22309"/>
        <property type="gene ID" value="B456_004G040100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790319"/>
    <dbReference type="eggNOG" id="KOG0439">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF119">
        <property type="entry name" value="VESICLE-ASSOCIATED PROTEIN 1-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="5">
        <location>
            <begin position="6"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB22309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="241" mass="26859" checksum="AFEF1D7150FCAAB2" modified="2015-04-29" version="1">MSTGQLLSIEPQELQFPFELRKQISCSLNLSNKTDNYVAFKVKTTNPKKYCVRPNTGVVLPRSTCNVVVTMQAQKEAPTDMQCKDKFLLQSVVASPGATPKDITAEMFNKESGHNVEECKLRVVYVAPPRPPSPVREGSEEGSSPRASVSDNGSFNAAELTSVSRAHVERHETQDNSYDARSLISKLTEEKNSAIQQNSKLQQELELLRREAKRNRSGIPFIYVFLVGLIGIILGYLLKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QS76</accession>
    <name>A0A0D2QS76_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_003G121900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QS76"/>
    <dbReference type="STRING" id="29730.A0A0D2QS76"/>
    <dbReference type="Gramene" id="KJB19861">
        <property type="protein sequence ID" value="KJB19861"/>
        <property type="gene ID" value="B456_003G121900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQAD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VYDNWIL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000002">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044965">
        <property type="entry name" value="Glyco_hydro_17_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32227">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00587">
        <property type="entry name" value="GLYCOSYL_HYDROL_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250543" description="glucan endo-1,3-beta-D-glucosidase" evidence="14">
        <location>
            <begin position="31"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB19861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="367" mass="40287" checksum="7CE3DB3FE57ACCAD" modified="2015-04-29" version="1">MHHSPSTSYLVMLISFFLASKFLLFPGVEGTIGVNYGTVASNLPPPAQVAHFLVESTIISRVRLFDADSNILKAFAHTGIAISVTVPNDEIPRLTKLNFAQQWVENNIQPYTPNTNIVRILVGNEVLSTANKLLIGSVVPAMQNLHSALFEASLDRRIQVSTPHSLGIISNSSPPSTAMFRQGYDTYVLKPLLSFLRATNSPFMVNPYPFFGCSLDTLDFALFRPNAGLDSVFSAMKFLGFDDVEIVIAETGWPSMGDSTQVGVDAKSAAEYNGNLIRHVISGAGTPLMPNRTFETYIFALFNEDLKEGPTCERNFGLFHTNMTPVYDNWILRRMTAAAAANFHPVTCLLVITIGFLVLAINHHGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXF5</accession>
    <name>A0A0D2QXF5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WAT1-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G424100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the drug/metabolite transporter (DMT) superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXF5"/>
    <dbReference type="STRING" id="29730.A0A0D2QXF5"/>
    <dbReference type="Gramene" id="KJB62587">
        <property type="protein sequence ID" value="KJB62587"/>
        <property type="gene ID" value="B456_009G424100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUF7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLMACIF"/>
    <dbReference type="OrthoDB" id="1728340at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030184">
        <property type="entry name" value="WAT1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31218">
        <property type="entry name" value="WAT1-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="184"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB62587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="377" mass="41525" checksum="2FD6B1188F898F0E" modified="2015-04-29" version="1">MGSLGKFKPYFAAIFLQVGLAGMDILSKAALNQGMSNYVLVVYRHAIATLVMAPFAVILEKKVRPKMTISIFIKIMVLSLLEPVIDQNLYYVGMKYTTATFAAAMYNILPAITFLMAWILRLEKVNLRSIRSHAKVFGTLATVAGAMVMTLMKGPVLELFWTTGRINNHEAAAKNRTDFHDTIKGGLLISVGCFSYACFVILQAVTLKTYPAELSLTVWICLMGTLEATVAALVMETGKASIWAIKWDTKLLTAAYSGIVCSGLAYYIQGVIMKDRGPVFVTAFSPLCMVIVAIMASFILAEQMFLGRVIGAIIIIVGLYLVLWGKSNEYKSQQPLMEQQIEAAKLDIGTNNENGSFDHQAIIIDEKSQERRDSIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QY04</accession>
    <name>A0A0D2QY04_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Aconitate hydratase</fullName>
            <shortName evidence="10">Aconitase</shortName>
            <ecNumber evidence="3 10">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G440000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="3 10"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QY04"/>
    <dbReference type="STRING" id="29730.A0A0D2QY04"/>
    <dbReference type="Gramene" id="KJB62847">
        <property type="protein sequence ID" value="KJB62847"/>
        <property type="gene ID" value="B456_009G440000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768448"/>
    <dbReference type="eggNOG" id="KOG0452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCSAPRW"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01586">
        <property type="entry name" value="AcnA_IRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000005">
        <property type="entry name" value="cytoplasmic aconitate hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006757">
        <property type="entry name" value="PRK09277.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009520">
        <property type="entry name" value="PRK12881.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="ACONITASE/IRON-RESPONSIVE ELEMENT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="11">
        <location>
            <begin position="160"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="12">
        <location>
            <begin position="792"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB62847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="993" mass="108662" checksum="69C8DE99C2A26F4E" modified="2015-04-29" version="1">MYCRARFASRLASTTAAASFSPSACSRVSSPIASPSSASSVSFWNQRYRSLSFSYSLRSLRCSAPRLHWRSPESLRVLARTSVPVVERFHRRIATTASEHPFKGVMTSLPKPGGGEFGKFYSLPALNDPRIDRLPYSIRILLESAIRNCDNFQVTKDDVEKIIDWENTSPKQVEIPFKPARVLLQDFTGVPAVVDLASMRDAMKNLGNDPKKINPLVPVDLVIDHSVQVDVARSENAVQENMELEFKRNKERFAFLKWGSSAFHNMLVVPPGSGIVHQVNLEYLGRVVFNSDGMLYPDSVVGTDSHTTMIDGLGVAGWGVGGIEAEAAMLGQPMSMVLPGVVGFKLAGKLRDGVTATDLVLTVTQMLRKHGVVGKFVEFYGEGMGELSLADRATIANMSPEYGATMGFFPVDHVTLQYLKLTGRSDETVSMIEAYLRANKMFVDYDEPQQERAYSSYLQLDLAEVEPCISGPKRPHDRVPLKEMKADWHACLDNNVGFKGFAVPKEEQNKVAKFTFHGLPAELRHGSVVIAAITSCTNTSNPSVMLGAGLVAKKAYELGLEVKPWIKTSLAPGSGVVTKYLLQSGLQKYLNQQGFNIVGYGCTTCIGNSGELDESVASAISENDIIAAAVLSGNRNFEGRVHPLTRANYLASPPLVVAYALAGTVDIDFEKEPIGTGKSGKSIYFKDIWPSNDEIAQVVQSSVLPDMFKSTYEAITKGNLMWNQLSVPASTLYSWDPNSTYIHEPPYFKNMTVEPPGPHGVKDAYCLLNFGDSITTDHISPAGSIQKDSPAAKFLLERGVDKKDFNSYGSRRGNDEVMARGTFANIRIVNKLLKGEVGPKTIHVPTGEKLYVYDAAMRYKAAGQDTIVLAGAEYGSGSSRDWAAKGPMLVGVKAVIAKSFERIHRSNLVGMGIIPLCFKPGEDADSLGLTGHERYSIDLPNKISEIRPGQDVTVTTDTGKSFTCTVRFDTEVELAYFDHGGILPFVIRNLNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZE3</accession>
    <name>A0A0D2QZE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_002G022600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZE3"/>
    <dbReference type="Gramene" id="KJB12520">
        <property type="protein sequence ID" value="KJB12520"/>
        <property type="gene ID" value="B456_002G022600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774437"/>
    <dbReference type="eggNOG" id="KOG1623">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIPLGMC"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008515">
        <property type="term" value="F:sucrose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000001">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000003">
        <property type="entry name" value="Bidirectional sugar transporter SWEET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047664">
        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF222">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="259"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="310" mass="34525" checksum="0E9B60B74614E722" modified="2015-04-29" version="1">MAIMSDHHAWAVAFGVLGNIISILVFLAPLSTFYRIYKKKSTESFQSLPYQVALFSCMLWLYYALIKKGAFLLITINSFGCIVETLYISMFLAYAPRKSRISAIKLFAAMNLGLFSLILIVTHFLVKNSIRIQVLGWINVAISVSVFAAPLNITTRVIKTKSVEFMPFNLSLALTLSAIMWFAYGAFIKDLCVAVPNVVGFILGMFQMILYAIYRNTDKVINVEDKKVPEEQTTTTTTISVLSKLGSSEVHPIDIDTIKNPNQNTTNQGDGNENDHTIEVDDDDDDDDGSSSHQKSLELSSELHLDESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R028</accession>
    <name>A0A0D2R028_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G063800</name>
        <name evidence="9" type="ORF">Gorai_014200</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R028"/>
    <dbReference type="SMR" id="A0A0D2R028"/>
    <dbReference type="Gramene" id="KJB22741">
        <property type="protein sequence ID" value="KJB22741"/>
        <property type="gene ID" value="B456_004G063800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793536"/>
    <dbReference type="eggNOG" id="ENOG502RY8E">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEPCSGL"/>
    <dbReference type="OrthoDB" id="551672at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14702">
        <property type="entry name" value="bZIP_plant_GBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000020">
        <property type="entry name" value="BZIP transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044521">
        <property type="entry name" value="AtbZIP8/43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045314">
        <property type="entry name" value="bZIP_plant_GBF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46324">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46324:SF3">
        <property type="entry name" value="BASIC LEUCINE ZIPPER 43-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="71"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB22741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0583339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="167" mass="19420" checksum="C5195BC11C806B8C" modified="2015-04-29" version="1">MQPSEISGLQYIVPSNPSPYSVPAFELSRFSNPLHNLYIPPQLQEIISPHPSCINNSTSDEADEQQLCVINERKQRRMISNRESARRSRMRKQRHLDELWSQVVWLRNENHQLIDKLNHVSESHDKVVEENVQLKEEASQLRRMLSDVQLTSPYSPLTDLEHALADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2R1</accession>
    <name>A0A0D2R2R1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_004G232400</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2R1"/>
    <dbReference type="STRING" id="29730.A0A0D2R2R1"/>
    <dbReference type="Gramene" id="KJB26239">
        <property type="protein sequence ID" value="KJB26239"/>
        <property type="gene ID" value="B456_004G232400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792423"/>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="THSVEWQ"/>
    <dbReference type="OrthoDB" id="275301at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06606">
        <property type="entry name" value="STKc_MAPKKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001090">
        <property type="entry name" value="Serine threonine protein kinase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052751">
        <property type="entry name" value="Plant_MAPKKK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTIONAL COMPLEX SUBUNIT CAF120-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48011:SF7">
        <property type="entry name" value="F10K1.14 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB26239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="495" mass="55419" checksum="7B237CF2BCE0D728" modified="2015-04-29" version="1">MEKQSNSKKPSWVRGKCLGKGAFGTVSLAIHQSDGAVFAVKSVDLATGVPSQLDSLENEIRILRSLSSPYVVEYLGDDVTKNETSAAGSRNLHVEYMQGGTVSDVAIVKQRLADLDERILRWHTRCLLSALKYMHGQGIVHCDVKGKNVLVGQDFSSVKLADFGSAIEIVKESRGDRCGTVITPRGSPLWMAPEVIRGEYQGPESDVWSLGCTVIEMVTGKPAWEDQGLKSLTRIANSDELPRLPAELSELGKDFVEKCLIRDRTQRWSCDQLLQHPFVASASAPSEIGESSPRCVLDFSSSDFEEDENTGNFETWARERISKLATEEGVVWESDGWVTVRSYARESGVNCEEGTSTEYPELMRIMKEMIEGTNLETADCSDGTHSVEWQCSNYKQSKRSKWSSGELRCGGWRCECSTGSSCLYGSQKMELAVGKGQLRIYMFCNLLLQLFFCNLRIFKYILLVFFNYSFLFTIFFTFSSQPQNFHSHHKNILGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R375</accession>
    <name>A0A0D2R375_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CEN-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G120400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylethanolamine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB23886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R375"/>
    <dbReference type="SMR" id="A0A0D2R375"/>
    <dbReference type="STRING" id="29730.A0A0D2R375"/>
    <dbReference type="Gramene" id="KJB23886">
        <property type="protein sequence ID" value="KJB23886"/>
        <property type="gene ID" value="B456_004G120400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791190"/>
    <dbReference type="eggNOG" id="KOG3346">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PSYTLIM"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009908">
        <property type="term" value="P:flower development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010228">
        <property type="term" value="P:vegetative to reproductive phase transition of meristem"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.280.10:FF:000001">
        <property type="entry name" value="Terminal flower 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001858">
        <property type="entry name" value="Phosphatidylethanolamine-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF108">
        <property type="entry name" value="PROTEIN BROTHER OF FT AND TFL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01220">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB23886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="19461" checksum="06F8C4A26F79E1E8" modified="2015-04-29" version="1">MSRVPDPLIIGRVIGEVVDNFFPSVKITVTYNSNKQVANGHELMPALITGRPRVEIGGDDMRPSYTLIMTDPDAPSPSDPYLIEHLHWMVTDIPGTTDASFGREVVSYETPKPTVGIHRYVFVLFKQRGRQTVRPPSSRDCFNTRRFSADNGLGLPVAAVYFNAQRETAARSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R590</accession>
    <name>A0A0D2R590_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_004G278900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB27114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="pollen receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Probable inactive receptor kinase RLK902"/>
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    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000095">
        <property type="entry name" value="protein STRUBBELIG-RECEPTOR FAMILY 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="At_inactive_RLKs"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
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    <dbReference type="InterPro" id="IPR032675">
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    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010:SF55">
        <property type="entry name" value="OS01G0607900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48010">
        <property type="entry name" value="OS05G0588300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002266480" description="Protein kinase domain-containing protein" evidence="13">
        <location>
            <begin position="23"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="331"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="603"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB27114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="637" mass="69807" checksum="2C0E821BA88E55FD" modified="2015-04-29" version="1">MTVNFSCFFLLSVLVLSSRVNSEPVQDKQALLAFLSKTKHPNRIQWNSSTSACDWVGVECDANRSFVFSLRLPGVGLVGSIPSNTIGRLNQLRVLSLRANRLSGEIPEDFSNLTLLRNLYLQDNAFTGEFPISVTRLARLTRLDLSSNKFAGPIPFAVNNMSHLTGLFLQNNKFSGSLPSINADGLDEFNVSNNSLNGSIPGSLSKFPKSSFAGNPALCGGPLRPCNPFFPSPEPSPIPPETPGEKSKNLSVGAIIGIAVGSTIIALLLLLFLILCLFKRRRQPPKPVTAPTGSVPPAEAGTSGGTTERERNKLVFFEGGIYSFDLEDLLRASAEVLGKGTVGTSYKAVLEEGTMVVVKRLKDVAANERVFEIHMETLGKMKHENLVPLRAFYYSDDEKLLVLDFMEEGSLSALLHGSRVSGRTPPNWDSRRKIALTAARGLAHLHVTGKVVHGNIKSSNILLRPDHEACMSDFGLNPIFSNTASSSRFSGYRAPEVVETRNVTFKSDVYSFGVVLLELLTGKSPNQTSMGEEGIDLPRWVQSVVREEWTAEVFDVELMRYHNIEEEMVQLLQIAMACVSIVPDQRPIMQEVVHLIEDVYRGETDDGLRQSSDDPSKGSDGYTPPIELRTPARSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R8B2</accession>
    <name>A0A0D2R8B2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G028500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8 9">Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but to a much less extent than Mg(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Early endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the NIPA (TC 2.A.7) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R8B2"/>
    <dbReference type="Gramene" id="KJB28119">
        <property type="protein sequence ID" value="KJB28119"/>
        <property type="gene ID" value="B456_005G028500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796492"/>
    <dbReference type="eggNOG" id="KOG2922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YGQTHMI"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF20">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 9" id="KW-0967">Endosome</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="240"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB28119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="322" mass="35319" checksum="C8DCFCC784EFF784" modified="2015-04-29" version="1">MNGMSMDNFRGLILAVSSSVFIGSSFIIKKQGLKKAGASGPRAGQGGHSYLYEPWWWAGMITMIIGEIANFAAYAYAPAILVTPLGALSIIFSAVLAHFILKERLHIFGMLGCALCVVGSTTIVLHAPKERHIESVKQVWHLATEPGFLVYFWVALAVVAVIIFHYVPRYGQTHLVVYIGICSLMGSLTVMGVKAVGIALKLSFGGVNQFKYFETWIFTIIVIFCCLLQINYLNKALDTFNTAVVCPVYYVMFTTFTIIASIIMFKDWNSQGGTEITTELCGFITILSGTFLLHKTKDMGKSSSGRLPVYSSPESNTVAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9I5</accession>
    <name>A0A0D2R9I5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF632 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G199800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9I5"/>
    <dbReference type="STRING" id="29730.A0A0D2R9I5"/>
    <dbReference type="Gramene" id="KJB15855">
        <property type="protein sequence ID" value="KJB15855"/>
        <property type="gene ID" value="B456_002G199800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105785937"/>
    <dbReference type="eggNOG" id="ENOG502QQQT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGLTRTW"/>
    <dbReference type="OrthoDB" id="1893612at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006868">
        <property type="entry name" value="DUF630"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006867">
        <property type="entry name" value="DUF632"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450:SF17">
        <property type="entry name" value="OS09G0542500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21450">
        <property type="entry name" value="PROTEIN ALTERED PHOSPHATE STARVATION RESPONSE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04783">
        <property type="entry name" value="DUF630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04782">
        <property type="entry name" value="DUF632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF630" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="DUF632" evidence="3">
        <location>
            <begin position="272"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="84935" checksum="C1EDFED8A7179434" modified="2015-04-29" version="1">MGCVASKLEEEEEVVSICRERKRLIKLAVDRRYALAEAHFRYCQALYAVSAAIKLFVARHSSPPSPFLITFPPPCPPTPPATDQNVITNPMLLQQRPSESTHEAIACESCGSSTSSDISDEETEPEVVREEQQQQQKQQHQHQHQHQHQPPPPCGYFYMQMPPPMPSPQRDFGWDFFNPFDVVRPEIISGYNRCSDDDLRAVREQEGIPELEEEGDTKEEEKKVVLVEEKDTKREQEESESGLLKVKEETHVSQGEQKGLTVIDSPEKGRELLEALKDIEDYFIRAYDSGKDVSRMLEANMVHLQSGLEGIKENSTKLIQAITWHRSTLSKPQSCKSLVASSSKSSSAWTEYKNDLFDQYGGMDSGSHSLTLERLYAWEKKLYEEVKAGDSTRKIYERKCSRLRNQDVKGYDELTMDKTRAAVKDLYARILIAIRSAESISKRIQNLRDEELLPQIIELLKGLTRTWKVMLESHETQNKILSEVKTFACPLYGKFCNDSHRLATLQLEAELQNWRACFTEYVAAQRAYIQALHGWLTKFLVPEVEFYSRGRSSGAPYGANGPPLLVICYNWLTSMDELPDKAVTFSLKSFSKDVKALWVQQGEEQQQKRKVDGMAKELDRRTMAFQKAETRFLESKLTEYKSEMETEQQNEYLTEKKDQLEMMRKRLDVEREKHHNHMQETQRITLNGLQTGFSTVFESLIEFSKASMKIYNDIVTLSEKMGNVSYIEGSSQVEENSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RCK3</accession>
    <name>A0A0D2RCK3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_010G235200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB68267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RCK3"/>
    <dbReference type="STRING" id="29730.A0A0D2RCK3"/>
    <dbReference type="Gramene" id="KJB68267">
        <property type="protein sequence ID" value="KJB68267"/>
        <property type="gene ID" value="B456_010G235200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773156"/>
    <dbReference type="eggNOG" id="KOG1454">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTTVHFW"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052370">
        <property type="entry name" value="Meta-cleavage_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139:SF37">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43139">
        <property type="entry name" value="SI:DKEY-122A22.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB68267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="330" mass="38274" checksum="70E4766B50C9F28B" modified="2015-04-29" version="1">MESKHLWQLISFYLSTTLALLRHLVLHILTLNQSPFIIKFMDLILSVYFRLCNLIPCAVDLDDQTTIHFWVTNHRRFDRPSLVMIHGYGGNPLWQFVYQVGPLSRRFNLYIPDLLFFGKSHSKSPFRSEFFQAKCLSDGLKRIGVDRFSVYAISYGGFVAYRMAEIRPDAVEKVAIVSSGLSFTDEQRDQQLRTIGRHPSEILVPKKPDDLRLLVNLSTFKQSTLKWVPDFLLRQFITLMYDHCRKEKIELADYLVKKKADPNLHVLTQETLIIWGDQDKVFPLELAYNLQRHLGKNSRLEIIKNVGHAANLESPDELNKLIFSFVIGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGR7</accession>
    <name>A0A0D2RGR7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G171300</name>
        <name evidence="3" type="ORF">Gorai_016926</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGR7"/>
    <dbReference type="Gramene" id="KJB30989">
        <property type="protein sequence ID" value="KJB30989"/>
        <property type="gene ID" value="B456_005G171300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794535"/>
    <dbReference type="eggNOG" id="ENOG502RZ3E">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
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    </dbReference>
    <dbReference type="InterPro" id="IPR003832">
        <property type="entry name" value="DUF212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31446">
        <property type="entry name" value="ACID PHOSPHATASE/VANADIUM-DEPENDENT HALOPEROXIDASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACID PHOSPHATASE_VANADIUM-DEPENDENT HALOPEROXIDASE-RELATED PROTEIN"/>
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    </dbReference>
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        <property type="entry name" value="DUF212"/>
        <property type="match status" value="1"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="12"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16838" checksum="E33374758B8A4A5B" modified="2015-04-29" version="1">MSSSWSSILTNYPLISAFIAFVIAQTIKFFTSWYKEKQWDLKQLVGSGGMPSSHSSTVTALATAIGFQEGFGGALFATALILACIVMYDATGVRLHAGRQAEVLNQIVYELPAEHPLAESRPLRELLGHTPPQVAAGGLLGIVTSFVGYFIFLDAR</sequence>
</entry>
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    </gene>
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        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB70412.1"/>
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        <property type="gene ID" value="B456_011G072000"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="PROTEIN SAWADEE HOMEODOMAIN HOMOLOG 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR33827">
        <property type="entry name" value="PROTEIN SAWADEE HOMEODOMAIN HOMOLOG 2"/>
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    </dbReference>
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        <location>
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            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
    <sequence length="246" mass="28575" checksum="DD3681B599E61C32" modified="2015-04-29" version="1">MVDNDSWDSLSEFTLAEILEMENKYKAIGDETLNEEFCNNLATRFSCSSNRLGKSTITWQQVQLFFQEKQMEVQTQQESSAMALKLFVDLSGEDSSKPLEVMQKRKGTVEDLKELSFEARSAKDYAWYDVETFLNYRVLCNGELEVRVRFAGFDKAEDEWVNVETAVRERSIPLEPSECGMVNIGDLVLCYLDREYYQLYCDAHVVDIQRQTHDDKGCTCVFVVCYDHDYSEENVSLERICRRPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
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            <fullName evidence="7">Uncharacterized protein</fullName>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Bedon F."/>
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                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
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                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <comment type="similarity">
        <text evidence="1">Belongs to the CLV3/ESR signal peptide family.</text>
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    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039618">
        <property type="entry name" value="CLE9-13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34359">
        <property type="entry name" value="CLAVATA3/ESR (CLE)-RELATED PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34359:SF5">
        <property type="entry name" value="CLAVATA3_ESR (CLE)-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="3" id="KW-0221">Differentiation</keyword>
    <keyword evidence="4" id="KW-0379">Hydroxylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007395395" evidence="6">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="11121" checksum="33BE00AD692523AC" modified="2015-04-29" version="1">MSCYRLFIFILLFLLLLQLARGSTPPPLPPSPRNHPPCDSFSRSEQRSLCFQLQRIHNFHPFLPSLAPPPPPSEANEIDPRYGVEKRLVPSGPNPLHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLX6</accession>
    <name>A0A0D2RLX6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G136500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLX6"/>
    <dbReference type="Gramene" id="KJB71667">
        <property type="protein sequence ID" value="KJB71667"/>
        <property type="gene ID" value="B456_011G136500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0335">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN HEXBP-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="139"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="2">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB71667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="227" mass="25933" checksum="55A4F8626BE92389" modified="2015-04-29" version="1">MDKMIVVSFMYSMYQKLRRIYGMFGWGNRYAFPQFLGPTTKRMFGWVMLLHPDSVPHLLPTLAVIAILMFKNGLGIPPIHYHLFRFLTSSSPTFARSRSLLGGKVFRSIGRVAYRDSPYSRDRRNNRHIAVECNSTTICWNCKEPGHLAGQCPYEPVCNMCCKMGHLARDCLNPRLPAHDARLCNNCYKAGHFVADCTNEKACNNCHKTGHLARDFHNEPVCNICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVB2</accession>
    <name>A0A0D2RVB2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_009G067100</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11 12">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVB2"/>
    <dbReference type="STRING" id="29730.A0A0D2RVB2"/>
    <dbReference type="Gramene" id="KJB55173">
        <property type="protein sequence ID" value="KJB55173"/>
        <property type="gene ID" value="B456_009G067100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768865"/>
    <dbReference type="eggNOG" id="KOG1058">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IYKNFDW"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000166">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="18"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="14">
        <location>
            <begin position="669"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="813"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB55173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="948" mass="105754" checksum="392B1D40B2EC6771" modified="2015-04-29" version="1">MEKSCTLLIHFDKGTPAIANEIKEALEGNDVPAKIDAMKKAIMLLLNGETLPQLFITIVRYVLPSEDHTVQKLLLLYLEIIEKTDTKGRVLPEMILICQNLRNNLQHPNEYIRGVTLRFLCRLNETEIIEPLIPSVLQNLEHRHPFIRRNAILAVMSIYKLPQGEQLLVDAPEMIEKVLSTEQDASAKRNAFLMLFTCAQDRAVNYLLTHVDRVSEWGELLQMVVLELIRKVCRTNRAEKGKYIKIIISLLNAPSTAVIYECAGTLVSLSSAPTAIRAAANTYCQLLLSQSDNNVKLIVLDRLNELKSSHRDIMVDLIMDVLRALSSPNLDIRRKTLDIVLELITPRNINEVVLMLKKEVMKTQSGELEKNGEYRQMLIQAIHSCAIKFPEVASTVVHLLMDFLGDSNVASAIDVVVFVREIIETNPKLRVSIITRLLDTFYQIRAARVCSCALWIIGEYCLSLSEVESGMATIKQCLGELPFYSVSEEGEATDASKKTPQANSITVSSRRPAVLADGTYATQSAASETAFSAPTVVQGSLASGNLRSLLLTGDFFLGAVVACTLTKLVLRLQEVQPSKVEVNKATTQALLIFVSMLQLGQSPVLPHPIDNDSNDRIVLCIRLLCDTGDGIRKIWLQSCRQSFVKMLSEKQLRETEELKAKAQVSHAQPDDLIDFYHLKSRKGMSQLELEDEVQDDLKRATGEFVNDNDDANKLNRILQLTGFSDPVYAEAYVTVHHYDIVLDITVINRTKETLQNLCLELATMGDLKLVERPQNYTLAPESSKQIKANIKVSSTETGVIFGNIVYETSNVLERTVVVLNDIHIDIMDYISPAVCTDAAFRTMWAEFEWENKVAVNTVIQDEKEFLNHIIKSTNMKCLTPVSALDDECGFLAANLYAKSVFGEDALVNLSVEKQADGKLSGYIRIRSKTQGIALSLGDKITLKQKGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RYL6</accession>
    <name>A0A0D2RYL6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G113800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RYL6"/>
    <dbReference type="Gramene" id="KJB56268">
        <property type="protein sequence ID" value="KJB56268"/>
        <property type="gene ID" value="B456_009G113800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770951"/>
    <dbReference type="eggNOG" id="ENOG502QTGY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MPSLMYY"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056555">
        <property type="entry name" value="NFD4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010658">
        <property type="entry name" value="Nodulin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21576">
        <property type="entry name" value="UNCHARACTERIZED NODULIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23262">
        <property type="entry name" value="NFD4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06813">
        <property type="entry name" value="Nodulin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250882" evidence="7">
        <location>
            <begin position="23"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Nodulin-like" evidence="8">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="NFD4 C-terminal" evidence="9">
        <location>
            <begin position="338"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="305"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB56268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="559" mass="61099" checksum="065D0D3A8DA8AB27" modified="2015-04-29" version="1">MPRIFLQWLSLVAIIWLQSINGTNSNFPAYSSQLKHLLSISQIQLNNLAFASDAGKLFGWLSGSAANYLPMWLVLILGSSLGLIGYGVQYLFLIGRVSNLSYGAIFFLAMLAGNSICWINTVCYLVIIRNFPLDSQLAVGLTGSYQGLSAKIYTDIVDVVYPCSNVERARAYLFLSSVLPLTVSVIVAPVVRVINTVKSKREEVAFILILIITTVTGAFAIMGSMGSASSLLSPFTGAVGMVALLLAPLPIPLGLGLRHQIGKLSGEKIHIEETNSVSMDKTESGVTLDISDIISESPSESFELSFSSTSEKMNGDQQSESSTSGDDKISETNETNSVMEEIGVKVMLRRLNFWLYFFVYLFAVTLGLVFFNNLGQIAESRGRSASSLVSLSSSFGFFGRLIPSIVDYFVSRRKYMISRPAFVVALMVPTGAAFFLLLVKDNTALWLYISTATIGVCTGAIASISVSLTTELFGTKNFGVNHNVLVINIPIGSFLFGYLAAIVYRKKVNAKGKCFGMECYRNTFILWGTLCFIGTFLALILYARTRKFYNSQRSQGNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S329</accession>
    <name>A0A0D2S329_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Guard cell S-type anion channel SLAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_004G204300</name>
        <name evidence="12" type="ORF">Gorai_015213</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLAC1 S-type anion channel family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S329"/>
    <dbReference type="STRING" id="29730.A0A0D2S329"/>
    <dbReference type="Gramene" id="KJB25690">
        <property type="protein sequence ID" value="KJB25690"/>
        <property type="gene ID" value="B456_004G204300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792137"/>
    <dbReference type="eggNOG" id="ENOG502QQKN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFVWQTL"/>
    <dbReference type="OrthoDB" id="1912323at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006873">
        <property type="term" value="P:intracellular monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090332">
        <property type="term" value="P:stomatal closure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09323">
        <property type="entry name" value="TDT_SLAC1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030183">
        <property type="entry name" value="SLAC/SLAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31269:SF11">
        <property type="entry name" value="GUARD CELL S-TYPE ANION CHANNEL SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31269">
        <property type="entry name" value="S-TYPE ANION CHANNEL SLAH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="481"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB25690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0584398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="561" mass="63218" checksum="9FE416D987BC85E4" modified="2015-04-29" version="1">MNNGASATSPHNSFQTHFLDIHEVLPEDEEEEGVIKMEDNKVTSSKRGLQKPIKLRELKRPQRSFNRQVSLETGFSVLGVESKAKDEKKVLRRSGRSFGGFDSANRVGAEARKGDFNIFRTKSTLSKQNSLLPTRKEKEMENQRAEGATGLNEPVNKSVPVGRYFDALRGPELDQVKDSEDILLPKDEIWPFLLRFPINCFGICLGLSSQAVLWRALSTSPATKFLHVTPFINLSLWLLALATLISVSITYLLKCIHYFEAVKREYFHPVRVNFFFAPWVVCMFLAIGLPPMLEPAKLHPAIWCAFMGPYFFLELKIYGQWLSGGKRRLCKVANPSSHLSVVGNFVGAILASKVGWIEAAKFLWSIGFAHYIVVFVTLYQRLPTSEALPKELHPVYSMFIAAPSAASIAWGSIYSEFDGCSRTCFFIALFLYISLVVRINFFTGFRFSVAWWSYTFPMTTASVATIKYAEQVPSVLSKGLALCLSVMSSTMVSVLFVSTLLHALFWKTLFPNDLAIAITKKRLVKEKKPFKKAYDIKRWTKQALTKNNSGDKEFNGENKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3Q5</accession>
    <name>A0A0D2S3Q5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_012G156300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxybenzoate 6-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3Q5"/>
    <dbReference type="STRING" id="29730.A0A0D2S3Q5"/>
    <dbReference type="Gramene" id="KJB77772">
        <property type="protein sequence ID" value="KJB77772"/>
        <property type="gene ID" value="B456_012G156300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EFNGAKH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044560">
        <property type="entry name" value="MOase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45934">
        <property type="entry name" value="FAD/NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45934:SF20">
        <property type="entry name" value="MONOOXYGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB77772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="73" mass="7804" checksum="4DCD55DCA07CB3A2" modified="2015-04-29" version="1" fragment="single">MEIVEDVVIVGAGVAGLTTSLGLHRLGIHSLVLESSDKLRITGFAFTTWSNAWKALDAIGIGESLRCQHNLIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SAF9</accession>
    <name>A0A0D2SAF9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_007G0971002</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the regulation of sugars and amino acids metabolisms during the night period.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(S)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:12653"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SAF9"/>
    <dbReference type="STRING" id="29730.A0A0D2SAF9"/>
    <dbReference type="Gramene" id="KJB41264">
        <property type="protein sequence ID" value="KJB41264"/>
        <property type="gene ID" value="B456_007G0971002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1257">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10380:FF:000005">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000237">
        <property type="entry name" value="Malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF73">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="16">
        <location>
            <begin position="108"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="15">
        <location>
            <begin position="298"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB41264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="581" mass="64060" checksum="26C62931C93F874E" modified="2015-04-29" version="1" fragment="single">MWNLTKFVASRLSRSRRFFSSVIPRPCIIQKRGADILHDPWINKETGFPLAERNRLGLRGLLPPRVISFEQQYARFMESYRSLEKNTVSEPDTSHVALAKWRILNRLHDRNETLYFRVLIDNIKDFAPIIYTPTVGLVCQNYSGLFRRPRGMYFSAKDKGEMMSMIYNWPAQKVDMIVLTDGSRILGLGDLGVHGIGIPIGKLDMYVAAAGLNPQRILPVMLDVGTNNLKLIEDPLYLGLRQPRLEGEEYLSIIDEFIEAVLTRWPKAIVQFEDFQMKWAFETLKRYRERFCMFNDDVQGTAGVALAGLLGTVRAQGRSLDDFPNQKIVVVGAGSAGLGVLSMAVQAVVRMTGNAETAAQNFFLLDKDGLITKERKNLDPAAVAFAKDPGLIAGLRDGDSLLEVVKKVKPDVLLGLSGVGGVFNEEVLKALRESGSNRPAIFAMSNPTMNAECTAVEAFKHAGENIVFASGSPFENVQLGNGKVGYVNQANNMYLFPGIGLGALLSGARIITDDMLQAAAECLASYMTDQDIEKGILYPSINSIRDITAEVGASVVRAAVAEEVAEGYGKVDPEELAYMSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBD4</accession>
    <name>A0A0D2SBD4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G098600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SBD4"/>
    <dbReference type="STRING" id="29730.A0A0D2SBD4"/>
    <dbReference type="Gramene" id="KJB80451">
        <property type="protein sequence ID" value="KJB80451"/>
        <property type="gene ID" value="B456_013G098600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80452">
        <property type="protein sequence ID" value="KJB80452"/>
        <property type="gene ID" value="B456_013G098600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80453">
        <property type="protein sequence ID" value="KJB80453"/>
        <property type="gene ID" value="B456_013G098600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80455">
        <property type="protein sequence ID" value="KJB80455"/>
        <property type="gene ID" value="B456_013G098600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105782938"/>
    <dbReference type="eggNOG" id="ENOG502QT8I">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESSMNPY"/>
    <dbReference type="OrthoDB" id="1923196at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18919">
        <property type="entry name" value="bHLH_AtBPE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000002">
        <property type="entry name" value="Basic helix-loop-helix transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024097">
        <property type="entry name" value="bHLH_ZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565:SF458">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="369"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="217"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB80452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="555" mass="59113" checksum="BFA46DA04EE3B92B" modified="2015-04-29" version="1">MDVGEKDKYELEKRNDNSLNYQASSMSSAWQFGGSNLTSTPMSLVSSDNPLVIGSSSASASMGDSFCSNLWEHPSNSQNLGFCDINVQNGASSSNAMGIGRGGPASVRGSIDRPFEMGWNASSSMLKGGIFLPNASGVLPSSLSQLPTDSAFIERAAKFSSFNGGNFSDIVNPFGIPEAMGVYARGVGLMQGPQDVYTISGIKSISGVESQRSKLITTEASRDLPAENRATQESPLKNERNGGSLVRSNEEAKQGNGGSGNESNEAESSGGAGGHDEPSALDGTAGESSAKILSSKKRKRSVQEAEVDQAKGSQSPVEATKDGAENQQKVDQNQTTMVNKTTAKHGKQGSQASDPPKEEYIHVRARRGQATNSHSLAERVRREKISERMKFLQDLVPGCNKVTGKAVMLDEIINYVQSLQRQVEFLSMKLATVNPRVDCNIEGLLAKDIIQSRAGPSTLGFSPDLSVGYPPLHPSQPGLGPGGFPVMENNADIIRRTLSSHFTPMTGGFKEPNQLSNAWEDELHNVVQMNYGTSTASDSQEVNGSQPSGHTKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SF91</accession>
    <name>A0A0D2SF91_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G384200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SF91"/>
    <dbReference type="Gramene" id="KJB61828">
        <property type="protein sequence ID" value="KJB61828"/>
        <property type="gene ID" value="B456_009G384200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HKWHTAT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000558">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At5g39710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938:SF35">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47938">
        <property type="entry name" value="RESPIRATORY COMPLEX I CHAPERONE (CIA84), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G06020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="285"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="355"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="390"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="425"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="652"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="722"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="757"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB61828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89131" checksum="A40DFE064E5EC967" modified="2015-04-29" version="1">MSMPVRGKGKRDHHFDNVDHALILFNKMIEKYPKPSIVEFTKLFAAIVRMKHYAIVVSKYRQIELLGVSHDVYSMSILINCFCQLGRIDFGFSVLGKMLKLGVEPDVVIFSTLINGLCNQSKISEAVCMFDEMIEKGYQPTSIVYSTMLKGLCKTGNTGRAQEEATRHLNEMVDNNISLDIVTYTLLIDALCKEGTISKAVEIVDTMRKQGIEPDVVTYSILVDAHCKEGMVSEAEGIVDEMIKRGIEPNVVTYNTLVNGHCLQNEMDKARRVFNLMIEKGCAPNIVTYNTMINGYCKGKRLDKAMELFHEISRKGPIPDTVTYNTLMQSMFQLGKISTACELFRKMLASGQVPDMATCLILLDGLCKTGHIEEALKLFQAMQNSELELDIVPYTILIDGFCKAGHIEVAKELFHQLSDNGLKPDVYSYCIMINGLCKEGLPDEAYRLFGSMGDNDCLPDSCCYNVMIRGFLCNSYTSKATQLLTEMANIQVMNLYRLLRTVTLTVIPLHCNVYSMSILINCFCQLGRIDFGFSVLGKMKKLGVEPSAVTFSTLINGLCNQGKISEAVCMFDEMTEKGYQPNLIVYSTVLKGLCKTGNTDRAVRFLRLMESRGYEPNIVAYNTVIDCLCKNGLLQEALNLLSEMKVKGIRPDIITYTCLIHGMCNLGQQEEATRLLNEMADNNISLDIVTYTLLIDALCKEGTISKAVQIVDTMRKQGIEPDVVTYNTLVDAHCKEGMVSEAEDFVDSMIKLEIEPDVVTYNALVNGHCLRNKMDKARRVFNLMIEKGCAPNIVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHS1</accession>
    <name>A0A0D2SHS1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G430300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHS1"/>
    <dbReference type="STRING" id="29730.A0A0D2SHS1"/>
    <dbReference type="Gramene" id="KJB62688">
        <property type="protein sequence ID" value="KJB62688"/>
        <property type="gene ID" value="B456_009G430300"/>
    </dbReference>
    <dbReference type="OMA" id="GICTWIY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022251">
        <property type="entry name" value="DUF3774_wound-induced"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33090">
        <property type="entry name" value="DUF3774 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12609">
        <property type="entry name" value="DUF3774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="93" mass="10191" checksum="7D161B13EBEBB319" modified="2015-04-29" version="1">MSCSTRAWIAAASSGAIEALKDQGICTWIYAQRSIQQHAKINIRSSSSSSTSQAKKICAPSSDNLFNKLGDDDKLKKYEESLRTVMLVIPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SI54</accession>
    <name>A0A0D2SI54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exostosin GT47 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_013G219000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 47 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SI54"/>
    <dbReference type="STRING" id="29730.A0A0D2SI54"/>
    <dbReference type="Gramene" id="KJB82887">
        <property type="protein sequence ID" value="KJB82887"/>
        <property type="gene ID" value="B456_013G219000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783322"/>
    <dbReference type="eggNOG" id="KOG1021">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004263">
        <property type="entry name" value="Exostosin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062:SF108">
        <property type="entry name" value="EXOSTOSIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11062">
        <property type="entry name" value="EXOSTOSIN HEPARAN SULFATE GLYCOSYLTRANSFERASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="Exostosin GT47" evidence="8">
        <location>
            <begin position="512"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="395"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB82887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="843" mass="94949" checksum="D759B1E50CB031E4" modified="2015-04-29" version="1">MGHELKSLSQLDTRKLIWLIGITFAVIVTFQYIELPYGNVLWSLFPSGKVSVDEKSSFLASGPSSAESGFYFNGTNAGNETVHDDEIFEGKDIDTDVITEADVGLNKSSTFGEGTKAWKESSTAEPVELNKNSTADKAGNETAHDDEIFEGRDLDADVITEADVGLNKSSTFDEGTKAWKESSTAEPVELNKNSTVDNAGNETAHDDEIFEGRDIDTDIITEADVGLNKSSTFNEGTKAPKESSTAELVLELNKNSTVNNAESSKSEEFEKDSNITSLNNLNQTGAVNETAKADDFTPEVGLNRSSILDKELDERSNITMLNIAESSNNKSVAENVGTSEESFASKNDTVDINTSNNNAPDTGLGTTNSTSEKGVKTNISAPVVSFNSSISSVEQHVTPSFDKNEKPKPKPIQNDFTKPSDNSSPRKAPKLKKKPEMLPPAVTTIADMNNLLYQSRVSYESPTPKWSSRADKVLLEARLQIENAPIIKNDPQLYAPLFRNLSMFKRSYELMENTLKVYVYKEGKRPIVHTPVLRGIYASEGWFMKQLESNKKFVTKNPRDAHLFYLPFSSRMLEETLYVPDSHSHKNLIEYLKNYVDTIAAKYPFWNRTEGADHFLVACHDWAPSETRNHMANCIRALCNSDVREGYVFGKDVSLPETYVRNPQKPLRDLGGNPPSKRPILAFFAGSMHGYLRPILLEQWGNKDPDMKIFGKMPNVKGKMNYIRHMKSSKYCLCPRGYEVNSPRVVEAIFYECVPVIISDNFVPPFFEVLNWESFSVFILEKDIPNLKKILLSIPIKRYRQMQLRVKKIQQHFLWHPKPEKYDIFHMILHSVWYNRVFQMKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SP69</accession>
    <name>A0A0D2SP69_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G215600</name>
        <name evidence="3" type="ORF">Gorai_019238</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SP69"/>
    <dbReference type="Gramene" id="KJB43781">
        <property type="protein sequence ID" value="KJB43781"/>
        <property type="gene ID" value="B456_007G215600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801536"/>
    <dbReference type="eggNOG" id="ENOG502QT1Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MEIHTFL"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF47">
        <property type="entry name" value="ACYL-TRANSFERASE FAMILY PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0590536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="48955" checksum="82AC81D041C2E897" modified="2015-04-29" version="1">MASIRFISSRIIQAGSRSKETDRIDLTPWDLKHLLVGYLQAGLLFHKPKLPEALIHHLQTSLSRTLDFFPPLAGRLATIEHEDKTTSFFIDCNNAGALFVHATAENVNISDLVEPVYVPETVDAFFQLDGVKNIEGTSKPLLAVQVTELVDGIFITCSANHSVVDGASFWHFFNSWSEISRGFDYLSRPPIFKRPLIDDIHYPIRIPLQKEHIQERFFQPGNLKVRVFNFRKESIVRIKRKANAEMNTDKISSLQALLSLFWQSIMRNRRMDPNQETMIFLVIGVRQKLQQLSEEYFGNAIHSAEVSLKAGELVEKGLGNAAWEINQVVANHREENFINFVKWWVNSPLLFQTGPMMNNALLTGNSPRFDIYGNDFGWGRPIAMSHGAESKCDGLVTVSPGVEEGDIEIKVCLSPKTIQAMENDEDFIAALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SR61</accession>
    <name>A0A0D2SR61_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_010G115900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as an effector of RABF2A and RABF2B. Involved in vacuolar transport of storage proteins. Regulates membrane trafficking to protein storage vacuoles (PSVs). Binds specifically to phosphatidylinositol 3-monophosphate (PtdIns3P).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SR61"/>
    <dbReference type="STRING" id="29730.A0A0D2SR61"/>
    <dbReference type="Gramene" id="KJB65843">
        <property type="protein sequence ID" value="KJB65843"/>
        <property type="gene ID" value="B456_010G115900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773136"/>
    <dbReference type="eggNOG" id="ENOG502QVII">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KHGMSNI"/>
    <dbReference type="OrthoDB" id="76516at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000060">
        <property type="entry name" value="Phox (PX) domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044588">
        <property type="entry name" value="EREX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46856:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN EREL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="12">
        <location>
            <begin position="48"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="500"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="708" mass="79565" checksum="1398BCB15B8B1B42" modified="2015-04-29" version="1">MMQRRSPPKHRHDGTSPLPLGMDWSPPPRKWNGRETVWPHDPRTGWSYCVTIPSWVVLPKSRDSDPVVFYRVHVGVQSPDGITTTRGVLRRFNDFLKLFNELKKAYPKKSLPPSPPKGLLRLKSRALLEERRCSLEEWMTKLLSDIDMSRSVSVASFLELEAAARSSFQELNECSSEANIAGNSTISSKVPSSSSISHFAGGSSITSDYGSDTAYETSELGTPRLGRDDSSEIGSGDLTLDEDLTGSIEKLVKYGMSNIDEGLFMGQAILEQLEDFPRHRTLAINMNSTSEKDIYNGNGSRASFTTGNGLELFSELEPAKVAGHARKLSTESFGSDVSFLRGSDMSISGIPNSSVNGFVDLPGTSEVLYTRGSLGNSDPQSSGDTKIVLPLDQRHKMNRVLLTMQRKLATAKTDMEDLVARLNQEIAVKGYLTTKVKDLEVELESTKQKSKENLQQAILIERERFTQMQWEMEELRQKSLEMELKLNPNQDEKQITETTNQLAAEEKDAMLQELNATKEQLNSISKRYEELELKSKADIKVLVKEVKSLRKSQKELKQEVGQSLSEKAEAEVQLVQERQIIKHVRNAREKLLNKCRLLHNRLLECSVNLSTDDENLIKDSSFVQEALDLLTTSDNKIILLLDEVQLLAKEEGSATGNDDIQLNNHYDSRTDDELRKIIAGIFTENANLKKQVNSHLRHKLKCDNHVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2STM3</accession>
    <name>A0A0D2STM3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G305200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2STM3"/>
    <dbReference type="STRING" id="29730.A0A0D2STM3"/>
    <dbReference type="Gramene" id="KJB45416">
        <property type="protein sequence ID" value="KJB45416"/>
        <property type="gene ID" value="B456_007G305200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761108"/>
    <dbReference type="eggNOG" id="ENOG502QV49">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTLGPHD"/>
    <dbReference type="OrthoDB" id="667051at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012442">
        <property type="entry name" value="DUF1645_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095:SF57">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095">
        <property type="entry name" value="OS07G0619500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07816">
        <property type="entry name" value="DUF1645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB45416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="381" mass="41674" checksum="57688C54F6A32F38" modified="2015-04-29" version="1">MEFQNPINKSNSSLASQLQITPNGQTLDPHDEPQVFHEDYDSTCSTPYVSAPSSPGRAPGPGPGSINGYGGFYYSAPASPMHFAMTSVSSSMVASTQPSSPDNNPVPLGFEFEFSARYGSSSGSGQTGSMSSADELFLNGKIRPMKLCTHLERPQVLAPLLDLEHEDEDNEVVDGKVRSRDLRLRDRSLRRRTRSMSPLRTATLGLCIDDQSMCLEQGLDKKADTADSNETSASMSASSSRSSSAGRSSKRWVFLKDFLRSKSEGRSNNHKFWSTISFSPAKEKKPGRKEKLSNNVSNGGSENQRSNKNNNNKPMNGISKRRVPPSPHELHYTANRAQAEEMRKKTFLPYRQGLLGCLGFSSKGYGAMNGLCKALNPVSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T167</accession>
    <name>A0A0D2T167_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SOUL heme-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_008G156100</name>
        <name evidence="4" type="ORF">Gorai_009679</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T167"/>
    <dbReference type="SMR" id="A0A0D2T167"/>
    <dbReference type="STRING" id="29730.A0A0D2T167"/>
    <dbReference type="Gramene" id="KJB50149">
        <property type="protein sequence ID" value="KJB50149"/>
        <property type="gene ID" value="B456_008G156100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764234"/>
    <dbReference type="eggNOG" id="ENOG502RZYR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HCEVWYV"/>
    <dbReference type="OrthoDB" id="6424451at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.80.10:FF:000002">
        <property type="entry name" value="Heme-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.80.10">
        <property type="entry name" value="Regulatory factor, effector binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011256">
        <property type="entry name" value="Reg_factor_effector_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006917">
        <property type="entry name" value="SOUL_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220:SF59">
        <property type="entry name" value="HEME-BINDING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11220">
        <property type="entry name" value="HEME-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04832">
        <property type="entry name" value="SOUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55136">
        <property type="entry name" value="Probable bacterial effector-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989140" description="SOUL heme-binding protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB50149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0592704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24368" checksum="51F132A524E661E9" modified="2015-04-29" version="1">MGQMKKFGFVLLVLSASVVEQIEGKGYEKPLNCGHLECAPYTLIHSQPEFEIRSYSKATWVATTPISSPSYTYAVSIGFKILFAYIRGNNDAAVKMNMTAPVLVNIHPRTGHLQNSTYVVHFYMPQKFQRNPPLSAEAQPVELPQHKYAAVRRFGGFMDDSNISVQLSALKKSLKGTGRDKSSASNQHSGRSLLYSAAGYNSPFEHENRVNEVMLWFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T1P8</accession>
    <name>A0A0D2T1P8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_011G032500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T1P8"/>
    <dbReference type="Gramene" id="KJB69593">
        <property type="protein sequence ID" value="KJB69593"/>
        <property type="gene ID" value="B456_011G032500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SAE6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040356">
        <property type="entry name" value="SPEAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33388">
        <property type="entry name" value="OS01G0212500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33388:SF19">
        <property type="entry name" value="SPOROCYTELESS-LIKE EAR-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB69593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="433" mass="46631" checksum="DC0EE1FCABBE9E43" modified="2015-04-29" version="1">MSSNNTSNIVGVRDMANGSGGGDYESSILRKAKKQRIPKRGPGVAELEKILREQEQKDGHTSSSLVPSLPNFYPSLPRSASFLADNHHHHHHPSSPPPSMAALHGNCSGSSQLRSCGNVGGNNGPGKGVYINGSGVYLPEQTLLPISWGSSEEPAPKMAADFSFPMPLSNGSGHTMLQRNHLSMMDLLPLSTLSSSSTTPSSTGVYHHVEPPSNQKPCYISTLLPEEDKFLLWISSLMFASKNMMSAKRSRPNVPVENWPAAAPSRMSFQQPIRPQVSRLDPSSSSTNNGVFSLGISGDPMPTNPLELKLKTCVNDNPSGNGNGNGNGSRPFITLLTSPTTTLPSTTQNCQPDLPKFIKQFPFQENNEGCLLQKSSSESEVLPVHNKSFFSFLLQPAEEVQRGSTSAEATLCLKTGNCCTEKTGDFIDLNLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T2I9</accession>
    <name>A0A0D2T2I9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_006G220900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T2I9"/>
    <dbReference type="STRING" id="29730.A0A0D2T2I9"/>
    <dbReference type="Gramene" id="KJB37805">
        <property type="protein sequence ID" value="KJB37805"/>
        <property type="gene ID" value="B456_006G220900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800356"/>
    <dbReference type="eggNOG" id="ENOG502QTAJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNRGIII"/>
    <dbReference type="OrthoDB" id="1918565at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22162">
        <property type="entry name" value="F-box_AtSKIP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025886">
        <property type="entry name" value="PP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32278:SF135">
        <property type="entry name" value="F-BOX PROTEIN PP2-B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14299">
        <property type="entry name" value="PP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB37805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="272" mass="31472" checksum="609D70D3D6046F46" modified="2015-04-29" version="1">MEITRILPEDCLCLIISLTSPADACRSAMVSHAFRSVADCDAVWEKFLPSDYRSIISSSLLSLGKKDVYFHMCFHPILIQNGTMSFQLEKESGKKCYMLGSKALSMIWLLRDTFMPFPWISTSLPGLSDRFPEVANINLVWWIEVKGKIETRNLSPNTNYVIYLVFKLRDRHTIELKHRTVGLHVNDDRVASWELRRVLIDPYRCEALYIRDRGDGWMEVEMGQFLNECGDDRTLEFSLRETDTSNFHNRGIIIEGIELRPKDISSLVDVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T843</accession>
    <name>A0A0D2T843_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G278400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T843"/>
    <dbReference type="SMR" id="A0A0D2T843"/>
    <dbReference type="STRING" id="29730.A0A0D2T843"/>
    <dbReference type="Gramene" id="KJB52769">
        <property type="protein sequence ID" value="KJB52769"/>
        <property type="gene ID" value="B456_008G278400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765554"/>
    <dbReference type="eggNOG" id="KOG0076">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HGFYKYM"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04160">
        <property type="entry name" value="Arfrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000914">
        <property type="entry name" value="ADP-ribosylation factor-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45909:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB52769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="203" mass="22937" checksum="946196D294FB5FC0" modified="2015-04-29" version="1">MFSLFYGLYKYLFSKTEFHVLILGIDKAGKTTLLEKLKSVYSNLEGLPPDRIVPTVGLNIGRVEVLNTKLVFWDLGGQPGLRSIWEKYYEEAHAVVFVIDAACPSRFEDSKSALEKVLRHEDLQGAPLLILANKQDLSEAVTAEELARYLDLKKLDERVYMFEAVSAFDGTGIKEGAEWLVEVMERSKRTEMLRNRAGMTGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TA31</accession>
    <name>A0A0D2TA31_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G213600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB51366"/>
        <property type="gene ID" value="B456_008G213600"/>
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        <property type="component" value="Chromosome 8"/>
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    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:response to ethylene"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:response to gibberellin"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="transcription factor MYB1R1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052245">
        <property type="entry name" value="Plant_Stress_Dev_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44191">
        <property type="entry name" value="TRANSCRIPTION FACTOR KUA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44191:SF45">
        <property type="entry name" value="TRANSCRIPTION FACTOR MYB1R1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="90"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="9">
        <location>
            <begin position="93"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="7">
        <location>
            <begin position="97"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21903" checksum="EC95490E849F29A8" modified="2015-04-29" version="1" fragment="single">MAKGTGRKCSHCGHNGHNSRTCSNGKGGYVKLFGVNIAAMAQTQECLMQRSFSMGNLPFHAENHNNGGGVDDGYFSEGHTHSENHNAAAHDIKRAKPWTEEEHRMFLEGLRKLGKGDWRGISKNYVTSRTPVQVASHAQKYFLRLQAAGNNRKKRRPSLFDMSFQESKSESVLPLNPILTTCLYVQFNLFMLMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB93</accession>
    <name>A0A0D2TB93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Cellulose synthase</fullName>
            <ecNumber evidence="23">2.4.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">B456_009G009700</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 23">
            <text>[(1-&gt;4)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;4)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19929"/>
            <dbReference type="Rhea" id="RHEA-COMP:10033"/>
            <dbReference type="Rhea" id="RHEA-COMP:10034"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18246"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="23">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="23">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 23">Glycan metabolism; plant cellulose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 23">Cell membrane</location>
            <topology evidence="2 23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 23">Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.12" evidence="23"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TB93"/>
    <dbReference type="SMR" id="A0A0D2TB93"/>
    <dbReference type="STRING" id="29730.A0A0D2TB93"/>
    <dbReference type="Gramene" id="KJB53884">
        <property type="protein sequence ID" value="KJB53884"/>
        <property type="gene ID" value="B456_009G009700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767347"/>
    <dbReference type="eggNOG" id="ENOG502QQXZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NGQVCEI"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="UniPathway" id="UPA00695"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016760">
        <property type="term" value="F:cellulose synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030244">
        <property type="term" value="P:cellulose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16617">
        <property type="entry name" value="mRING-HC-C4C4_CesA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000031">
        <property type="entry name" value="Cellulose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000009">
        <property type="entry name" value="Cellulose synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005150">
        <property type="entry name" value="Cellulose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027934">
        <property type="entry name" value="CES_Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13301">
        <property type="entry name" value="X-BOX TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03552">
        <property type="entry name" value="Cellulose_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14569">
        <property type="entry name" value="zf-UDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 23" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17 23" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="12 23" id="KW-0135">Cellulose biosynthesis</keyword>
    <keyword evidence="6 23" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 23" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 23" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 22 23" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="850"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="929"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="970"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1000"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="371"/>
        </location>
    </feature>
    <feature type="active site" evidence="19">
        <location>
            <position position="739"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>UDP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR605150-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU361116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="KJB53884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117502" checksum="6B24E1D6DCE25635" modified="2015-04-29" version="1">MEASAGLVAGSHNRNELVVIHGHEEPKPLKNLDGQVCEICGDEIGLTVDGDLFVACNECGFPVCRPCYEYERREGSQQCPQCKTRYKRLKGSPRVEGDEDEEDVDDIEHEFNIDDEQNKYRNIAESMLHGKMSYGRGPEDDEGLQIPPGLAGVRSRPVSGEFPIGSSLAYGEHMSNKRVHPYPMSEPGSARWDEKKEGGWRERMDDWKMQQGNLGPEPDDAYDADMAMLDEARQPLSRKVPIASSKINPYRMVIVARLVILAFFLRYRILNPVHDAIGLWLTSVICEIWFAFSWILDQFPKWFPIDRETYLDRLSLRYEREGEPNMLASVDIFVSTVDPLKEPPLVTANTVLSILAMDYPVDKISCYISDDGASMLTFESLSQTAEFARKWVPFCKKFAIEPRAPEMYFTLKVDYLKDKVQPTFVKERRAMKREYEEFKVRINALVAKAQKVPPEGWIMQDGTPWPGNNTKDHPGMIQVFLGQSGGHDTEGNELPRLVYVSREKRPGFLHHKKAGAMNALVRVSGVLTNAPFMLNLDCDHYLNNSKAVREAMCFLMDPQIGRKVCYVQFPQRFDGIDRHDRYANRNTVFFDINMKGLDGIQGPVYVGTGCVFRRQALYGYEPPKGPKRPKMVTCGCCPCFGRRRKDKKHSKDGGNANGLSLEAAEDDKELLMSHMNFEKKFGQSAIFVTSTLMEQGGVPPSSSPAALLKEAIHVISCGYEDKTEWGSELGWIYGSITEDILTGFKMHCRGWRSIYCMPKLPAFKGSAPINLSDRLNQVLRWALGSVEIFFSHHCPAWYGFKGGKLKWLERFAYVNTTIYPFTSLPLLAYCTLPAICLLTDKFIMPPISTFASLFFIALFLSIFATGILELRWSGVSIEEWWRNEQFWVIGGISAHLFAVIQGLLKVLAGIDTNFTVTSKATDDEEFGELYTFKWTTLLIPPTTVLIINLVGVVAGISDAINNGYQSWGPLFGKLFFSFWVIVHLYPFLKGLMGRQNRTPTIVVIWSVLLASIFSLLWVRIDPFVMKTKGPDTTMCGINC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TID0</accession>
    <name>A0A0D2TID0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_007G200700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the SFH family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TID0"/>
    <dbReference type="Gramene" id="KJB43445">
        <property type="protein sequence ID" value="KJB43445"/>
        <property type="gene ID" value="B456_007G200700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1471">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.525.10:FF:000011">
        <property type="entry name" value="SEC14 cytosolic factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF29">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL_PHOSPHATIDYLCHOLINE TRANSFER PROTEIN SFH12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="11">
        <location>
            <begin position="114"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="312"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="487"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB43445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="577" mass="65075" checksum="6554DB55D2CC2E69" modified="2015-04-29" version="1">MDASEEEKIRRGSFKKTASNRFRNSRKRRSSKVISVEIDDERDTEEMQSVETLRQALIAEDMLPEKHDDYHTLLRFLKARRFDIEKTKQMWGDMLKWRKEFGTDTILEDFEFKEREEVLKYYPQGYHGVDKDGRPVYIERIGLVDATKLMQVTTMDRYLKYHVGEFEKTFKIKFPSCSIAAKKHIDQSTTLLDVQGVGLKSFTKAARELITLLQKVDGDNYPETLNRMFILNAGSGFRMLWNTVKSFLDPKTTAKINVLGNKFQSKLLEIIDADQLPDFLGGTCTCAEHGGCMLSDKGPWKDPEILKMVQSGQYKAGNKSRAQSSEEKTTTKEETPAPKASDSVDAEPVPEAAKKQPEPPPVKEEVEIITPKIVTPVVLDKPVVIATPDENAVVVPKGTELAIVPKVDANRQEVLRVPDGLSSHLFTGVMTFVMGIGAMMKVTRNMPRKPTDPTNYVSQVESVGTVAKSQDPSAQLTQPVGLSTAELMSVMKRMAELEERLSVINQKPTTMPPEKEELLNTALTRADALEQELMATKKALEDSFAQQQELAAYIDKKKKKKKKTLKLICWYPSSGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TMC0</accession>
    <name>A0A0D2TMC0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Glutamate receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_009G186500</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">Glutamate-gated receptor that probably acts as non-selective cation channel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TMC0"/>
    <dbReference type="STRING" id="29730.A0A0D2TMC0"/>
    <dbReference type="Gramene" id="KJB57940">
        <property type="protein sequence ID" value="KJB57940"/>
        <property type="gene ID" value="B456_009G186500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57942">
        <property type="protein sequence ID" value="KJB57942"/>
        <property type="gene ID" value="B456_009G186500"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57944">
        <property type="protein sequence ID" value="KJB57944"/>
        <property type="gene ID" value="B456_009G186500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769021"/>
    <dbReference type="eggNOG" id="KOG1052">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ATRSPCI"/>
    <dbReference type="OrthoDB" id="5984008at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015276">
        <property type="term" value="F:ligand-gated monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901701">
        <property type="term" value="P:cellular response to oxygen-containing compound"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009611">
        <property type="term" value="P:response to wounding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13686">
        <property type="entry name" value="GluR_Plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19990">
        <property type="entry name" value="PBP1_GABAb_receptor_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000037">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000054">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000175">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000081">
        <property type="entry name" value="Glutamate receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001828">
        <property type="entry name" value="ANF_lig-bd_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044440">
        <property type="entry name" value="GABAb_receptor_plant_PBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019594">
        <property type="entry name" value="Glu/Gly-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015683">
        <property type="entry name" value="Ionotropic_Glu_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001320">
        <property type="entry name" value="Iontro_rcpt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017103">
        <property type="entry name" value="Iontropic_Glu_rcpt_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18966">
        <property type="entry name" value="IONOTROPIC GLUTAMATE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01094">
        <property type="entry name" value="ANF_receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00060">
        <property type="entry name" value="Lig_chan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10613">
        <property type="entry name" value="Lig_chan-Glu_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037090">
        <property type="entry name" value="Iontro_Glu-like_rcpt_pln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01176">
        <property type="entry name" value="GABABRECEPTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00079">
        <property type="entry name" value="PBPe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="Periplasmic binding protein-like I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 13" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="8 13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010907764" description="Glutamate receptor" evidence="17">
        <location>
            <begin position="23"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="620"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="830"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Ionotropic glutamate receptor C-terminal" evidence="18">
        <location>
            <begin position="469"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="881"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="759"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR037090-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB57944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="909" mass="100797" checksum="71CC7345FB75A95C" modified="2015-04-29" version="1">MNVAGFIFLLSLHLGVFQIGYGRNASTRPAVVNIGAMFNFDSIIGRVAKIAIDEALKDVNSNSSILKGTKLSVTLQDTNCNGFLGMVEALRYMATDVVAIIGPQCSVVAPIISHVASELRVPLLSFAATDPTLSSLQFPFFVRTAQSDLYQMTAVADIIDHYGWKEVIAIFIDDDWGRNGVSALNDKLAERRCKISYKVGIQPDSSVTQGAIMDILVKVALMQSRIVVLHLNQIVGFKVFSVANHLGMMGNGYVWIATDWLSLVLDSESPLPSETMDKIQGVLTLRQHTTDSDRKRAFFARWNRIIGGSPQLNAYGLYAYDTVWLLAHSLDAFFNQGGVISFSNDSRISSMAGSALHLEAMSIFDDGVLLLKNILLSDFVGLTGPLKFNSDRSLILPAYDIINVLGTGIRQIGYWSNYSGLSTVSPETLYTKPQNRSSANQKLYSVIWPGETLSKPRGWVFPNNGKLLRIGVPNRVSYKEFVSQVRGTDMFKGFCIDVFTAAVNLLPYAVPYKFISFGDGRKNPSYTELVNKITTGEFDAVVGDIAIVTNRTRIVDFTQPYVSSGLVIVAQLEKERSGAWAFLQPFSRRMWIVTGSFFLIVGIVVWILEHRINDEFRGPPKQQVITILWFSFSTMFFAHRENTMSTLGRLVLLVWLFVVLIINSSYTASLTSILTVEHLSSPIKGIQSLAATNEPIGYQEGSFTERYLSEELNISRSRLVSLGSPEAYALALKRGPGNGGVAAVVDERPYVELFLSSQCTFKVVGQEFTKSGWGFAFPRDSPLAIDMSTAILALAENGDLQRIHDKWLMQSTCSLESTEIETNQLNLSSFWGLFLICGIACIIALLIYFLQILQQLPPAPESASITGQDSSHSRRLRRFLSLMDEKEEQSRSGQKRRKVDNERDDEFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TMU2</accession>
    <name>A0A0D2TMU2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G200800</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TMU2"/>
    <dbReference type="STRING" id="29730.A0A0D2TMU2"/>
    <dbReference type="Gramene" id="KJB58179">
        <property type="protein sequence ID" value="KJB58179"/>
        <property type="gene ID" value="B456_009G200800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769057"/>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CNIVGAC"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF1">
        <property type="entry name" value="OS01G0105900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="4">
        <location>
            <begin position="82"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB58179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="368" mass="39286" checksum="9C470C624976B33F" modified="2015-04-29" version="1">MGAETLLKNGEARVQLDPKVPLILGLQPAALIDHVARVDGSLFDQIPGERGGSIPVAMEELEHILSELKRHVLASADDSSPMKTMAGGSVANTIRGLSSGFGVNCGMIGAYGDDEQGQLFACNMNTSGVNVSRLRKKKGPTAQCVCLVDAFGNRTMRPCLATAVKVQGDELTKGDFSGSKWLVMRFGAFNLEVIQAAIRIAKQQGVSVSLDLASFEMVRNFRVPLQQLLESGDIDLCFANEDEATELLRGEGNAHPEAAVEYLSKYCRWAVVTLGSNGCIAKLGKEIVQVPAIGEAKAVDATGAGDLFASGFLYGLVKGLSLEECCKVGSCSGGSVIRSLGGEVTPENWQWMYKQMQRKGLSLPDIRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TPG3</accession>
    <name>A0A0D2TPG3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G140200</name>
        <name evidence="3" type="ORF">Gorai_004788</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TPG3"/>
    <dbReference type="STRING" id="29730.A0A0D2TPG3"/>
    <dbReference type="Gramene" id="KJB77493">
        <property type="protein sequence ID" value="KJB77493"/>
        <property type="gene ID" value="B456_012G140200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780681"/>
    <dbReference type="eggNOG" id="ENOG502QSIC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RFFHLVW"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42841">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB77493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0601615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="480" mass="52075" checksum="116175F9E1394D15" modified="2015-04-29" version="1">MPLTLPPSSSFSFLSPTAKSTHSHRFFTIPHASTTQLAPKPPPVIKTAPVIVIGAGLAGLAAATRLNSDNIPFLLLEASDGVGGRVRTDVVDGFLLDRGFQIFITAYPEAQKLLNYNELNLRKFYSGARIYYDGKFHTVADPLRHFSDSLLSLGNPIGSVLDKLLIALTRVRVLSNSYEEIMSADEVSTIQLLKNIGFSDSMIGRFFRPFFGGIFFDPQLETTSRLFDFVFKCLALGDNTLPAKGIGEIPNQLAAKLPSDSLLLNTKVVSVDSDDSNSPSVTLESGEILKSELGVIMAVEQPAVDKILAGKKQPPPPPGQRKKPARSTVCLYFSMDQDQVPVQDPVLFLNGSGKGIINNMFFATNVAPSYGPSNKALASVSLIGLYENTADDDLRAEVIKELSGWFGASKVESWRHLRTYRIGFAQPNQSPPTDLMKNPNIGPGLYLCGDYMTSATFDGALVSGRRAVEALLKDRALALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TQ87</accession>
    <name>A0A0D2TQ87_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G156400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the 3-hydroxybenzoate 6-hydroxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TQ87"/>
    <dbReference type="STRING" id="29730.A0A0D2TQ87"/>
    <dbReference type="Gramene" id="KJB77773">
        <property type="protein sequence ID" value="KJB77773"/>
        <property type="gene ID" value="B456_012G156400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2614">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009523">
        <property type="term" value="C:photosystem II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009767">
        <property type="term" value="P:photosynthetic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.860">
        <property type="entry name" value="Photosystem II cytochrome b559, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044560">
        <property type="entry name" value="MOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037025">
        <property type="entry name" value="PSII_cyt_b559_asu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013082">
        <property type="entry name" value="PSII_cytb559_asu_lum"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45934">
        <property type="entry name" value="FAD/NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45934:SF20">
        <property type="entry name" value="MONOOXYGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00284">
        <property type="entry name" value="Cytochrom_B559a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161045">
        <property type="entry name" value="Cytochrome b559 subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Photosystem II cytochrome b559 alpha subunit lumenal region" evidence="4">
        <location>
            <begin position="410"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB77773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="50153" checksum="1E97D5DDE9676D72" modified="2015-04-29" version="1">MSSHSVGMEIVEDVVIVGAGIAGLTTSLGLHRLGIRSLVLESSEGLRITGFAFTTWENAWKALDAIGIGDSLRRLHYLLSSIVVASTVLEKPAVSEMSFKGHDIRCVQRRLLLETLAKELPNGTIRFSSKVVSIDESEDHFKRLHLADGAILKTKVLIGCDGVNSVVAKWLGLQNPVFSGRSSIRGNAHFKGGHGFEPKLRQFAGKGFRSGFLPCDDENVYWFLTWTPATKEEEMEDNPLKLKQLVTSKLKDASDEMKSVIEKTLLDDITSSPLRYRKPWELLWGNISKGNVCVAGDALHPMTPDIGQGGCSALEDGVVLARCLGEALLKPGVEDEEYERIETGLKKYGQERKWRSFDLITTAFMVGFIQQHEGKVMSYLRDKFMLRFLSGLLSRKAGFDCGWLFVSTGLAYDVFGSPRPNEYFTESRQGIPLITGRFDSLEQLDEFSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TRA3</accession>
    <name>A0A0D2TRA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G167600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TRA3"/>
    <dbReference type="STRING" id="29730.A0A0D2TRA3"/>
    <dbReference type="Gramene" id="KJB57510">
        <property type="protein sequence ID" value="KJB57510"/>
        <property type="gene ID" value="B456_009G167600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57511">
        <property type="protein sequence ID" value="KJB57511"/>
        <property type="gene ID" value="B456_009G167600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RGRS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="REYHASH"/>
    <dbReference type="OrthoDB" id="1935339at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052650">
        <property type="entry name" value="Zinc_finger_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36886">
        <property type="entry name" value="PROTEIN FRIGIDA-ESSENTIAL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36886:SF3">
        <property type="entry name" value="PROTEIN FRIGIDA-ESSENTIAL 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="253"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="308"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB57511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="774" mass="85510" checksum="198E201E615E3E37" modified="2015-04-29" version="1">MPLSTPAAVPRADKDDERRTASTTRPEFNSSDMEIDDDDEEERGEELQVSSKRNDGSNIMESKGHVGHSGSDPLSAPGRSEMRIPSKTLYVGESSASFNLCSLPDEPWATQREDLCKNYDGSKYPISGKRPANEKAIQEYGVNGQDARVIFERKAHEDHHEQHTSSTVNEIMYEATNLISVDGKEIAINDVISILGRYHSGVGVSSHLGFEQKSKQMGMQTEDNKRSMKSRSSAPQTSTGSLYPGAEFNSENKRPALICDFFARGWCVKGSSCKFIHIKDSGSNPSQQSEEDAAEADEKIAVQLDEGIQNTAEKSRPPSPGSSDRLPSSARNRTTLSPLIQSKDKSIGTSLGSQQFQASTDDSEPSKDVRQTSIGKSLPADNYVKPGLLSDRGSSTFGNGFLPKHIPYLSGSDTYLGNTYKENQKYRVSTWLASLPFSSSSSACSVDAQKMLKNDREHHTSRPSSLLRGFSSLSSFEPENFPATDIAKDPLHFAEYRIKISSEDWEPSVPFRPSFFITFGPSSPRREYDPLRDSIDLSNVGERSLKFSFSSQGPSLLDVAYPPTYDDSTSAGPLVPACNADKITASCHGRYVENLVNNNCYTSGKDSTTDANDWTSAADMQNGTLVKEEISSVASHVKDISKTSKADTDRDARHRRDGFRCKKDLKVDRVREKNEIDIEHKADGEALKESKAMRHFHAALVDLIKELLKPTWREGHLSKDAHNRIVKKAVNKVIGTVQPHQIPLTFESVKQYLSASQSKIARLVQGYIEKYGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TU15</accession>
    <name>A0A0D2TU15_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G227200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter (TC 2.A.67.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TU15"/>
    <dbReference type="Gramene" id="KJB58811">
        <property type="protein sequence ID" value="KJB58811"/>
        <property type="gene ID" value="B456_009G227200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771180"/>
    <dbReference type="eggNOG" id="KOG2262">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLYCMIG"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="534"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="655"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB58811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="741" mass="82543" checksum="E5DFA134415AF5DF" modified="2015-04-29" version="1">MSSLEIGSARVGDVLVVSAADNDDVSPIEEVRLTVSNDDDTTLPVWTFRMWFIGLLSCVLLSFLNTFFSYRSEPLQVTMISIQVASLPVGKFMARVLPTTKFKIPVVNKEFTLNPGPFNVKEHVLISIFANAGAAFGGGTAYAISIVDIIRAFYHRKIGFLASWILVITTQVLGYGWAGIMRRFVVEPAEMWWPSSLVQVSLFRAMHEKDNSRKSRGKFFLIALICSFSWYVFPGYLFPTLSAISWVCWAFPKSVTAQQIGSGMQGIGIGSFAVDWSVIASFLGSPLVTPFFAIVNIFVGFALFLYVVLPTAYWGLDLYQARNFPIFSSHLFNHKGEPYNVSGIVNQNFEIDMPAYEQQGLVNLSVFFSLTYGIGFAAIISTLSHVAVFNGKEIHTQLKASFKGKEDIHTRLMKKYKSIPNWWFYLLLGLTLLLSLALCVFMKRDIQMPWWGLIFAAAIALAFTLPVSIITATTNQSPGLNIITEYIMGYILPGKPIANVCFKTYGYISMAQAVSFLNDFKLGHYMKIPPRSMFVVQSIGTVIAGTVNLAVAWWLLTTVENICQDHLLPPNSPWTCPGDRVFFDASVIWGLVGPKRIFGPLGNYSALNWFFLGGAVGPVVVWLFHKAFPNQKWIPLINLPVLLGATAAMPPATSLNFNCWLIIGFIFNYYVFKYRKGWWQRYNYVLSAALDAGLAFMGVLLYFTLTMHGISISWWGSDGEHCDLASCPTAKGIVVDGCPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYS3</accession>
    <name>A0A0D2TYS3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G328600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TYS3"/>
    <dbReference type="Gramene" id="KJB60831">
        <property type="protein sequence ID" value="KJB60831"/>
        <property type="gene ID" value="B456_009G328600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771422"/>
    <dbReference type="eggNOG" id="ENOG502QVG7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7763451at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000820">
        <property type="entry name" value="RNA recognition motif-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF29">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="32"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB60831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="309" mass="33358" checksum="5F26646A49EEB10E" modified="2015-04-29" version="1">MSIPLDQTNLTLGAVTEASATANWTINASNIRTVKVSNISLAASERDIKEFFSFSGDIQYVEMRRETENAQVAYVTFKDTQGADTAILLTGAKIVDLSVNITPVEDYQLPPEALLSNTEKKPVVADSTVQKAEDMVSTMLAKGFILGKDAINKAKAFDEQHHLTSNASAAVTSFDQKIGLSEKLSIGTAVVNEKMREMDGRFQVSETTRFALSVAEQKASIAGTAIMSNSYVSTGASWLSNAFTAVARAAEDVGMLTKEKVGKAEEEKKGSVYKERARIIEDFAELHLDESPKAEPSVGLVDSTTDKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYY2</accession>
    <name>A0A0D2TYY2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IBB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G390800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TYY2"/>
    <dbReference type="STRING" id="29730.A0A0D2TYY2"/>
    <dbReference type="Gramene" id="KJB61914">
        <property type="protein sequence ID" value="KJB61914"/>
        <property type="gene ID" value="B456_009G390800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766549"/>
    <dbReference type="eggNOG" id="ENOG502QPV8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TMPHEKY"/>
    <dbReference type="OrthoDB" id="2538345at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34689:SF1">
        <property type="entry name" value="NUCLEIC ACID-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB61914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="38664" checksum="83850D4D7987A3D9" modified="2015-04-29" version="1">MGKYRNGSLSENSDEETGTPSKPKPKHKSDSESEDTKPRSHSKSDKGKRPSKSRRRHDSSSGISEDDSYSDSESESESQSEYSGTESGYSDSEEERRRRKRKRREREERERKRRKKEKEKKRRRKEKERDEERKRKKRKEKERKAKKKKDKLEKGKKGAVTNSWGKYGIIRETDMWNKRPEFTAWLAEVKQINLESLPNWEEKQLFKDFMEDHNTATFPSKKYYNLDAYYKCQMEKENKKGVKKVLQGERTVFNDEEQRRQEMLMAREKQKEEEVQALKLAMQSGMAQAMKEQTQLREEMAYLYKIGNFEAAAAIQKRLDPDVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U946</accession>
    <name>A0A0D2U946_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_010G093000</name>
        <name evidence="14" type="ORF">Gorai_007477</name>
    </gene>
    <organism evidence="13 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14 16" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="14" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="14">8</strain>
            <tissue evidence="14">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May be involved in plant defense signaling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0597677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U946"/>
    <dbReference type="STRING" id="29730.A0A0D2U946"/>
    <dbReference type="Gramene" id="KJB65394">
        <property type="protein sequence ID" value="KJB65394"/>
        <property type="gene ID" value="B456_010G093000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1187">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NAESPCG"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000228">
        <property type="entry name" value="Serine/threonine-protein kinase BIK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000032">
        <property type="entry name" value="Serine/threonine-protein kinase PBS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050823">
        <property type="entry name" value="Plant_Ser_Thr_Prot_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45621">
        <property type="entry name" value="OS01G0588500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="81"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB65394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="MBA0597677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="426" mass="47836" checksum="50B01DC02D708113" modified="2015-04-29" version="1">MTVKKITWKSLMLSCYNSKDIISPSDSGEKDSKPCQFQRLSMSDVSDRSSPLSVDDLSTSLLGSNLHVFTFAELRLITHNFARCNLLGEGGFGPVYKGFIDDKLRPGLKAQPVAVKALDLDGLQGHREWLAEIIFLGQLRHPHLVKLIGYCYEEDNRVLVYEYMPRGSLENQLFRRYSAPLPWSARMKITLAAARGLAFLHEADKPVIFRDFKSSNILLDSDYNCKLSDFGLAKDGPEGEQTHVTTRVMGTQGYAAPEYIMTGHLTTMSDVYSFGVVLLELLTGKRSVDNSRPGREQSLVEWARPLLRDPKKLDKLIDARLERQFSYKGAQKVAALAYKCLSHQPKPRPSMGDVVKILDSVQGFEDEFVGPFVYVVPNETGDDKELFTTKDCGVEKHELHRCGWRNRIKLPLSLVVNAESPCGISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2U951</accession>
    <name>A0A0D2U951_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">valine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G298900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2U951"/>
    <dbReference type="STRING" id="29730.A0A0D2U951"/>
    <dbReference type="Gramene" id="KJB52110">
        <property type="protein sequence ID" value="KJB52110"/>
        <property type="gene ID" value="B456_008G298900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0432">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.380:FF:000001">
        <property type="entry name" value="Valine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="entry name" value="Valyl-tRNA synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF93">
        <property type="entry name" value="VALINE--TRNA LIGASE, CHLOROPLASTIC_MITOCHONDRIAL 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Valyl-tRNA synthetase tRNA-binding arm" evidence="10">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="11535" checksum="A45D54B71FEBE099" modified="2015-04-29" version="1">MQEEKEVLALLSKLDLDNIHFTDSPPEDAKQSVHLIASEGLEAYLPLADMVDISAEVQRLTKRLSKMQTEYEGLKARLNSPKFIEKAPKDVVRGVQEKAAEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAV8</accession>
    <name>A0A0D2UAV8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G276300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAV8"/>
    <dbReference type="STRING" id="29730.A0A0D2UAV8"/>
    <dbReference type="Gramene" id="KJB52780">
        <property type="protein sequence ID" value="KJB52780"/>
        <property type="gene ID" value="B456_008G276300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765528"/>
    <dbReference type="eggNOG" id="KOG1135">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MHVGGDM"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035194">
        <property type="term" value="P:regulatory ncRNA-mediated post-transcriptional gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000008">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="8">
        <location>
            <begin position="244"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB52780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="742" mass="82063" checksum="36BB3976DA545AF5" modified="2015-04-29" version="1">MGTSVQVTPLCGVYNENPLSYLVSIDGFNFLIDCGWNDLFDPSLLQPLSRVASTVDAVLLSHSDTLHLGALPYAMKQFGLSAPFYSTEPVHRLGLLTMYDHYLSRKQVSDFDLFSLDDIDAAFQSIARLTYSQNYHLSGKGEGIVIAPHVAGHLLGGTVWKITKDGEDVIYAVDFNRRKEKHLNGTVLESFVRPAVLITDAYNALNNQPPKPQRERDRDFVEIISKTLEGGGNVLLPVDTAGRVLELLLVLEENWSLKSLNFPIYFVTYVSASTIDYVKSFLEWMSDAIAKSFETSRDNAFLLKNIKLLTSKSELDSVPDGPKVILASMASLEAGFSHDIFVEWAADVKNLVLFTERGQFGTLARMLQADPPPKAVKVTMSRRVPLTGEELIAYEEEQNRLKKEEALKASLIKEEESKASLATDVNSSDPMVIDTHNKHPSLDGLGQHGSRFRDVLIDGFVPPSSSVAPMFPFYDNTSDWDDFGEVINPDDYVIKDEDMDQGATRTGGDMDGKLDEGSASLILDTTPSKVISNELTVQVKSSLVYMDYEGRSDGRSVKSILAHVAPLKLVLVHGSAEATEHLKQHCLKHVCPHVYAPQIEETIDVTSDLCAYKVQLSEKLMSNVLFKKLGDYEIAWVDAEVGKTENDMLSLLPISTPAPPHKSVVVGDLKMADFKQFLASKGVKVEFAAGALRCGEYVTLRKVGVASQKGGGSGTQQIIIEGPLCEDYYKIREYLYSQFYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFG6</accession>
    <name>A0A0D2UFG6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit OST5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_009G031700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OST5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFG6"/>
    <dbReference type="SMR" id="A0A0D2UFG6"/>
    <dbReference type="STRING" id="29730.A0A0D2UFG6"/>
    <dbReference type="Gramene" id="KJB54380">
        <property type="protein sequence ID" value="KJB54380"/>
        <property type="gene ID" value="B456_009G031700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768760"/>
    <dbReference type="eggNOG" id="KOG4452">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MERYVGP"/>
    <dbReference type="OrthoDB" id="18408at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007915">
        <property type="entry name" value="TMEM258/Ost5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13636">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05251">
        <property type="entry name" value="Ost5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB54380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8215" checksum="3367C65F95ACFE81" modified="2015-04-29" version="1">MAPPAKAITSPVPDAWYPTLAVFMLAIGLVLTASFFIYEATSSKRNRSLAKELTTGGVASVFLGFGSLFLLLSAGVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UFR6</accession>
    <name>A0A0D2UFR6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G035700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UFR6"/>
    <dbReference type="STRING" id="29730.A0A0D2UFR6"/>
    <dbReference type="Gramene" id="KJB54484">
        <property type="protein sequence ID" value="KJB54484"/>
        <property type="gene ID" value="B456_009G035700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB54485">
        <property type="protein sequence ID" value="KJB54485"/>
        <property type="gene ID" value="B456_009G035700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768291"/>
    <dbReference type="eggNOG" id="KOG4210">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="691484at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051992">
        <property type="entry name" value="OxStress_Response_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172">
        <property type="entry name" value="OS08G0516900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33172:SF96">
        <property type="entry name" value="PROTEIN OXIDATIVE STRESS 3 LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB54485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="246" mass="26870" checksum="D1BCDE12651E7EEC" modified="2015-04-29" version="1">MSLVYDRNNENSSSMRRSGFIHGMQCISVYDSPEEKRDDRLRLLSTEEEEEERDDDESGSCSSSSIGRNSDDSGESPSDDDDSPEPEVQSQLKGPLDTMDALQEILPLRKGISKFYNGKSKSFTSLADAAAVSSVKDFAKPEDPYNRKRKNLLARSSSLDKKPNNLLGNIGTKISMASSPSNCLPPLHPQCKKSTTIIKPSSSSFTARPNPPCRSYSLSDLQFVAATTPNMAGLAVHSGNKGNKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR41</accession>
    <name>A0A0D2UR41_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase kinase kinase</fullName>
            <ecNumber evidence="2">2.7.11.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G104700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.25" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR41"/>
    <dbReference type="STRING" id="29730.A0A0D2UR41"/>
    <dbReference type="Gramene" id="KJB71079">
        <property type="protein sequence ID" value="KJB71079"/>
        <property type="gene ID" value="B456_011G104700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB71080">
        <property type="protein sequence ID" value="KJB71080"/>
        <property type="gene ID" value="B456_011G104700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0198">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000357">
        <property type="entry name" value="Mitogen-activated protein kinase kinase kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="334"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB71079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="613" mass="67534" checksum="CA8A291C2E18D5A7" modified="2015-04-29" version="1">MRWLQSLSFSSSSSSSSSSSSSSTCTGKNCKENHNNKNHKQCYNFGFRLGVSKLTRPRELRRVKDQEVAPTKEGTAPLLSAGYHTPLSSPTSSFRGTTPALPVPLPLPLPVPEGDSEQRLSPKEFGLGKGLEDRDKEKADGTPPNLSVFACRGCWKTTDHAKTRPMKALSQEMIIEDSFEDECRANVPIRSAPASPSSSHAIICPQSKNAGDMFPHHMFSPSYHAWSAPEMSTLGTPVVPPLAFYDYGGFSSDNTPFHSPPNRSPHRRQSSHSGPTSPIQQWVSPDISPSRLESNGHINVHPLPLPPGAAIACTSASITQVTTNPDPLPMNCQWQKGKLIGRGTFGSVYVASNRETGALCAMKEVEICPDDPKSAECIKQLEQEIKVLSHLKHPNIVQYYGSEIAEDKFYIYLEYVHPGSINKYVRDHYGAITESVIRNFTRHILSGLAYLHSTKTIHRDIKGANLLVDASGVVKLADFGMSKHLSGQRADLSLKGSPYWMAPELLQAVMQKDNRSELALAVDIWSLGCTIIEMYTGKAPWSEYEGAAAMFKVLRDTPPTPETLSPEGKDFLRCCFQRNPADRPSASMLLEHRFIKCTNSRVSHHLTDNVHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UTC9</accession>
    <name>A0A0D2UTC9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pectinesterase inhibitor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G256300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UTC9"/>
    <dbReference type="Gramene" id="KJB59255">
        <property type="protein sequence ID" value="KJB59255"/>
        <property type="gene ID" value="B456_009G256300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S7NT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NCCDESY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31890">
        <property type="entry name" value="PLANT INVERTASE/PECTIN METHYLESTERASE INHIBITOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31890:SF9">
        <property type="entry name" value="PLANT INVERTASE_PECTIN METHYLESTERASE INHIBITOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252939" description="Pectinesterase inhibitor domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23081" checksum="733F8330450F6F4A" modified="2015-04-29" version="1">MAPPNQFCFVSVMFLSILSVSSLPTSALTPKANVSFFVPSSQLLENLCNGKAVQNRRFCLKEPSTPEVITVMDTTQLGTLIMKLGAVNAKATLNVYNEIIKKPGSPQALKVLNCCDESYKYAILSFEMVSSELVEDPQIANYDVAVIGPEIGNCEKELINAKVQAPQLLAGNQFMKYYVSMGYEITSTLELENPNDIRQKIKGICIDNNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UV96</accession>
    <name>A0A0D2UV96_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G177800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UV96"/>
    <dbReference type="Gramene" id="KJB72426">
        <property type="protein sequence ID" value="KJB72426"/>
        <property type="gene ID" value="B456_011G177800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YMILAEM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000090">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF347">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="448"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="519"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="588"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB72426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="635" mass="71924" checksum="A70ADB45025FF188" modified="2015-04-29" version="1">MLFSKLNRSFPTRLSRHFSLSAPTFLKDNQTSIGISSIKPHNYRISVFMKNGLIQEAQNLFDKMPQKNVVTWNTMIRGYFLNGFFSKAIAMFQETPERDIFTCNIVISGLMHDHDVQGARQVFEGMVCRDVVTWNAMIGGYFINGMLDKGLKIFEEMPVKDVISWNLVIEGLVKCGKLDLAEEYFKRMSYRDVASWTVMISGLAKAGRMADACKYFEEMPVKDVRAWNVILEGYIGIECVDLAESIFHEMPGKDLDSWKLLINGLVRCRRLVNALGYFMKMPTKCCKTLNSILLGLIRNGHVKEGHAFLEKQPYNNVVSWTNVVVGYFGIGEVRSAVKVFESMPIRDVTMWNVMICGLGETNFGEEGSKFFIRMKESGFHPDEATFTSILTICSNLPSLDLGNQIHAQVVKSGLNHFTAISNALVTMYERCGNMHSALLEFISMQRHDFISWNSIICGFAHHGNAEKALEMFERMRLTDVKPNHITFIGVLSACSHAGLIDKGKYYFDYMKSKCSLQPTTEHYTCIVDLLGRFGLIDEAMSFLNQMRADGIEVPASVWGALLGACRIHNNMELGMIAAERVLEKEPRNSGIYLILAEMYLSCGRRDEAESIRARMEEKGVRKQQGRSWVEVNNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXZ4</accession>
    <name>A0A0D2UXZ4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G336900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXZ4"/>
    <dbReference type="Gramene" id="KJB61040">
        <property type="protein sequence ID" value="KJB61040"/>
        <property type="gene ID" value="B456_009G336900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766002"/>
    <dbReference type="eggNOG" id="KOG0773">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VHSKWPY"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005540">
        <property type="entry name" value="KNOX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005541">
        <property type="entry name" value="KNOX2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03790">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03791">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01255">
        <property type="entry name" value="KNOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01256">
        <property type="entry name" value="KNOX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="232"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="234"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB61040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="313" mass="35622" checksum="E8BB397DACAC6F43" modified="2015-04-29" version="1">MDEIYGFYSMGDQYVDNALMSPENMIFPSDYQPRLCSSDRVPAFGSDELISVASAISEAAYVTPQIQGEVDISNVIKAKIASHPYYPRLLEAYIDCQKVGAPPEIARILDEILMETDVNKRDILPTCLGADPELDEFMETYCDMLVKYKSDISRPFDEATTFLNKIEMQLRNLCTGASITGLSDEGGESSEGDVSVGEDDVEELQPRSKDIGLKDLLLHRFGNHITTLKLEFSKKKKKGKLPKEARQILLEWWNVHSKWPYPTEGDKMALAETTGLDPKQINNWFINQRKRHWKPSETFQMDELSGRFFIDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UZC4</accession>
    <name>A0A0D2UZC4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trichome birefringence-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G294400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PC-esterase family. TBL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UZC4"/>
    <dbReference type="STRING" id="29730.A0A0D2UZC4"/>
    <dbReference type="Gramene" id="KJB74424">
        <property type="protein sequence ID" value="KJB74424"/>
        <property type="gene ID" value="B456_011G294400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQHY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ASHAANC"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016413">
        <property type="term" value="F:O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029962">
        <property type="entry name" value="TBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026057">
        <property type="entry name" value="TBL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285:SF36">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32285">
        <property type="entry name" value="PROTEIN TRICHOME BIREFRINGENCE-LIKE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13839">
        <property type="entry name" value="PC-Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trichome birefringence-like C-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB74424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="241" mass="28258" checksum="81FDCEA565D6A917" modified="2015-04-29" version="1">MGQHFLSGIITQDLHNHTVSTVTFKHYKVSVMLFRSLYLVDVDKETIGRVLKLNSVRNGNLWKEIDVLIFNTWHRWHRRGLKQQWDYVQFDGKIRKDIDRTVAFRTALRTWAKWVDSDVDTNRTKVIFQGISPSHYNGIDWNEPGVRNCSRQTTPFKGSIYPTGLPLAEYVVKEVIRNIKKPVHLLDITMLSQLRKDAHPSTYNDFNGMDCTHWSLPASPIHGIYFCMQLSSNSREIWFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V0X4</accession>
    <name>A0A0D2V0X4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sieve element occlusion N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_012G028700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V0X4"/>
    <dbReference type="STRING" id="29730.A0A0D2V0X4"/>
    <dbReference type="Gramene" id="KJB75171">
        <property type="protein sequence ID" value="KJB75171"/>
        <property type="gene ID" value="B456_012G028700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QS6Q">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TIMEDYQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010088">
        <property type="term" value="P:phloem development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027944">
        <property type="entry name" value="SEO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027942">
        <property type="entry name" value="SEO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039299">
        <property type="entry name" value="SEOA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33232">
        <property type="entry name" value="PROTEIN SIEVE ELEMENT OCCLUSION B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33232:SF15">
        <property type="entry name" value="PROTEIN SIEVE ELEMENT OCCLUSION B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14577">
        <property type="entry name" value="SEO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14576">
        <property type="entry name" value="SEO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sieve element occlusion N-terminal" evidence="1">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Sieve element occlusion C-terminal" evidence="2">
        <location>
            <begin position="429"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB75171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="74341" checksum="8705D34DCA21A314" modified="2015-04-29" version="1">MAAETKTPPASRYYSFDKSSQQIQMTNKTNSFQTLEPDVGQHLLDLIQSIFQVVVASKDIDQSAELNKMISSLETFQGMRQVLNDIRDISCEMSCNLLAAGSGNVEKTRTAVLERLRSYSWSAKVVIAIAAFASSIGELSMLVKHRDDEPMAKFLVNILKGYSPKLDLNALAEAKLIEGMLKVVRTNLDFSNRLKQESMKEAMLELYLNATKNIFDIVLQISTVLSRREDVHVELESLSKQLTEINIQLQDNMKYFGAERISPNWYEEVSEISTSELIAKIKKYIEVRDSEKLRNKHVLFLISDLNISIEEIKVLERLYEKNEGKYEIVWLPIVGSLAYDKKAAARFWELRQMTKWIGVEPSRIEEEVIQYIKRDWHFIKEAIAVSVNEVGEITCLNALPMLWAWGNRAFPFTDKITLWNELDERNGWTWRLDLLFDQLILPGDSGIDIQSWTKSEGTLVCLFGGGDISWNQEFIQKVKYAARSAGVTLKLVYLGVGKNKGKGLTRNQLGRDVLVIQSESQWQFWSRLESILYAKIRLGKKDEVMQEALKVVGYGGNGEEWAMFSMGEGAMVTTSGKTALTIMEDYQMWRSDMIGVRFLEGIKKYKELITRDVHSCINLHLPVMGQIPGIMICPECSKVMDVFYTYRCCPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V1H1</accession>
    <name>A0A0D2V1H1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G038600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V1H1"/>
    <dbReference type="STRING" id="29730.A0A0D2V1H1"/>
    <dbReference type="Gramene" id="KJB75369">
        <property type="protein sequence ID" value="KJB75369"/>
        <property type="gene ID" value="B456_012G038600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2753">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="196"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB75369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="436" mass="49097" checksum="040431924F5F9557" modified="2015-04-29" version="1">MTTVVPTSEEDPVLPVVRFTADLSWADAGPEVAEPLVTRLCMEAQECMVMGRWLDLASLMLTSAELVFPKVSDKDLECIFTVICNLASKLENPDDELEMAKLISTKISQQPNDKPAMRLKILFNLYNLLEGPDSRFFVYMQALNLALNGKVIDHIVPSFKKIDSFLKEWNIGVKDQRNLFLTIANVLKENKSSGKDSFKFLTKYLATFSGEDSCVIGEAKEEAVRAVIEFVKAPDTFWCDLLDMPAVGQLEKDAKYALVYQLLKIFLTQRLDAYLEFQAANSTLMKSYGLVHEDCITKMRLMSLVDLGSNESGQIPYALIKDALRVNLLSSACLPHLLHDLGCSLMYFSLQINDDEVELWIVKAITAKLIDCKMDQMNQVVIVSRCTERIFGQHQWHSLRLKLATWRGNVDSLISTIQANKVVEEGSQAMQGMAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VAQ0</accession>
    <name>A0A0D2VAQ0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_010G151700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VAQ0"/>
    <dbReference type="Gramene" id="KJB66675">
        <property type="protein sequence ID" value="KJB66675"/>
        <property type="gene ID" value="B456_010G151700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66676">
        <property type="protein sequence ID" value="KJB66676"/>
        <property type="gene ID" value="B456_010G151700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB66675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="103" mass="12439" checksum="4EA5703CD6D786ED" modified="2015-04-29" version="1">MIKKQETSWNILCLSPLVKCHIVKVLLYILCLTVETRNKLEYFMFMYFFLGNRSLQFYLGIWYDELQTMEDDLSKIPEDQEDVSRLSTVFEAQEKLKRFYNGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VC11</accession>
    <name>A0A0D2VC11_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G105700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in the accumulation of some potyvirus during viral infection.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VC11"/>
    <dbReference type="STRING" id="29730.A0A0D2VC11"/>
    <dbReference type="Gramene" id="KJB80591">
        <property type="protein sequence ID" value="KJB80591"/>
        <property type="gene ID" value="B456_013G105700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0401">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000027">
        <property type="entry name" value="Eukaryotic translation initiation factor isoform 4G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000036">
        <property type="entry name" value="Eukaryotic translation initiation factor isoform 4G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF53">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR ISOFORM 4G-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="MI" evidence="7">
        <location>
            <begin position="619"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="784" mass="86422" checksum="9493E2DA161946E2" modified="2015-04-29" version="1">MQQGDQTVLSLRPGGGRGSRLFGAPSSSSSSSSLAFGSLSSDLPVFRPHAGAPPAFSIKAGDSRFEGRECVQYTRDQLLKLRVAVEVSDDILKIKREIEVELFGEDQNRTRGESNPPNQSQNRYSEPDNRDWRNRSAQFSSDGEERSWESLHDRELGNHYDSKQPEASQFNRRAQISFNQLNCSFWMVGQGGQTPALVKAEVPWSARRGNLSEKDRVLKTVKGILNKLTPEKYDLLKGQLIDSGITSADILKGVISLIFEKAVLEPTFCPMYALLCSDLNDKLPSFPSDEPGGKEITFKRVLLNNCQEAFEGADKLREEVAQMTAPELEMERREKERLVKLRTLGNIRLIGELLKQKMVPEKIVHHIVQELLGHDTKGCPVEENVEAICQFFNTIGKQLDESLKSRRINDAYFNRLKELVTNPQLASRLRFMVRDVLDLRADNWVPRREEVKAKTITEIHSEAEKNLGLRPGATASIRNSRIVSVGPISPGGLPITRPGTGGLMPGMPGTRRMPGMPGMENDNWEVPRTRSMPRGDGLGMLPVGRVPSPSINKPTSVNPRLLPQGSGGLMSGRTSALLQGSSSPPVAQPSLPAKPVLVAAVSPALEKPVTPASRLNQDELSRKTKALLEEYFSVRLLDEALQCVEELKSPGYYPEVVKEAISIALEKIPPCVEPVSKLIEYLFIKKVLTARDIGTGCLLYGALLDDIGIDLPKAPNNFGEIIGKLALAGGLDFNVVREILKKMEDDLYQKAVFDAAMRIVSSSPSGQAVLEAQASEVKVCQSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VD03</accession>
    <name>A0A0D2VD03_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G125400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the formin-like family. Class-I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VD03"/>
    <dbReference type="STRING" id="29730.A0A0D2VD03"/>
    <dbReference type="Gramene" id="KJB81016">
        <property type="protein sequence ID" value="KJB81016"/>
        <property type="gene ID" value="B456_013G125400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784570"/>
    <dbReference type="eggNOG" id="KOG1922">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NEENRAF"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027643">
        <property type="entry name" value="Formin-like_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213:SF177">
        <property type="entry name" value="FORMIN-LIKE PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23213">
        <property type="entry name" value="FORMIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253469" description="Formin-like protein" evidence="4">
        <location>
            <begin position="29"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="5">
        <location>
            <begin position="382"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="245"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB81016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="806" mass="89207" checksum="48B040E0A9FEC052" modified="2015-04-29" version="1">MGYGSQIHPMIFLTFLFISLQRSHILVAEGLLLDKAVDFRVHGLQQLFFMDETVGNNNQVENVSGQDDKFTKRRVPLTGVANCFPPSPSPNIRAEASVPAPPKVAHFHPPPPQSTTRPPPQITHKGNADKRIVGRILVPLLVSAGAAFLACVLGLCCFCAKTSKNKRKGRIRGKSKYKSAQSSSSKVMLNPGSDLFYLDTLVDLEQQSICLKQSTETEKISSNYSTLNHGFDKMEESNKEVAILKSQNASSSSTREITPIHEDGQSERYDGNCSLSDKRIPMECPSSDDESFHSFVDPHSPPPPPPPPPPPPLPPVVGVRPSNSSLSATKARHKASSSSTLLNVTPARNSDSSTGSNVNPSDIPHSPQTPSNSLPSPPGIPLGKDGSPLPKLKPLHWDKVKAAPDRSMVWDKLRSSSFELDEETIESLFGYNIQNPIKNDETKSKTPSPSKHVLEPKRLQNITILLKALNVTPEQAYNALMKGNGLVLQQLEALVKMVPTKEEEAKLYSYNGDINELGYAEKFIKALLSIPFAFLRAEAMLFRETFEDEVIHLKNSFSMLEEACKELRSSRLFLKLLEAVLKTGNRMNVGTIRGGATVFKLDTLLKLADVKGTDGKTTLLHFVVQEIIRSEGIRVSDTDTITGKMNESNKSQTAEEKEEDYKRRGLDLVSGLSTELYHVKKTATIDLDVLVTSVSNLSNGKDKLKNLVMEELSRDEKNENFIRSMNSFLDYAENNIKEVQEDEHRVLLHVREIAEYFHGDVSKLEEANPLGIFLVVRDFLGMLDHVCKELRNSKTPSSPSPLAPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VDM9</accession>
    <name>A0A0D2VDM9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G112500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VDM9"/>
    <dbReference type="STRING" id="29730.A0A0D2VDM9"/>
    <dbReference type="Gramene" id="KJB80729">
        <property type="protein sequence ID" value="KJB80729"/>
        <property type="gene ID" value="B456_013G112500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783490"/>
    <dbReference type="eggNOG" id="ENOG502RXKC">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GNGWRER"/>
    <dbReference type="OrthoDB" id="47513at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37754">
        <property type="entry name" value="CALCIUM ION-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37754:SF4">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="165" mass="18613" checksum="CBF696FAA14D689F" modified="2015-04-29" version="1">MGQVLEKFHGKEWRKRQIRKISDKVFERVKNQSGRATLTFEDLYIAVLLVYNDINKRLPGPHFDPPSKDQIRSMMQECDLNLDGQINHDEFVKFIQKLTTDTLVVVSQGLLVTLVVAPTVAMATKKATEGVPGVGKVVQKLPNAIYASLVTLAMVWFQTSREGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGA3</accession>
    <name>A0A0D2VGA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_013G201100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGA3"/>
    <dbReference type="SMR" id="A0A0D2VGA3"/>
    <dbReference type="STRING" id="29730.A0A0D2VGA3"/>
    <dbReference type="Gramene" id="KJB82531">
        <property type="protein sequence ID" value="KJB82531"/>
        <property type="gene ID" value="B456_013G201100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783591"/>
    <dbReference type="eggNOG" id="KOG0027">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FCLLDMD"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000202">
        <property type="entry name" value="Calmodulin-like protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
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    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB82531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="151" mass="17188" checksum="A44D1BAD90CF8AE1" modified="2015-04-29" version="1">MGEIMSEELIAEFQEAFCLFDKDGDGCITMEELAIAIKSLDQNPTQEELQNMINEVDSNGNGTIEFGEFLNLMATKMKEAEAEDELKEAFRVFDKDQDGYISPYELRLVMMNIGEKLTDEELEQMIREADLDGDGRVNYEEFVRMMLAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VGG2</accession>
    <name>A0A0D2VGG2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WPP domain-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G004700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VGG2"/>
    <dbReference type="STRING" id="29730.A0A0D2VGG2"/>
    <dbReference type="Gramene" id="KJB69085">
        <property type="protein sequence ID" value="KJB69085"/>
        <property type="gene ID" value="B456_011G004700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPVR">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037490">
        <property type="entry name" value="WAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33883">
        <property type="entry name" value="WPP DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33883:SF10">
        <property type="entry name" value="WPP DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="636"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="815"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB69085.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="910" mass="103400" checksum="D4A674BCFFA022BD" modified="2015-04-29" version="1">MNLFTASKQKNSFKCNLMVGGNSEMESCIDANSSAVSCCDESVHGTVSVGDPIKDSGELDVEFLNEFDLYVEDIKDGLVVSRMVNDSIIRGMVNAVEQEAADRIAQKELELVRLKEMLKSYHVGSDENQLLRPLTKNNDPNIGKLSAFSRLSDALTDHDKILESFGRLKSAAKGQLKNLRIDIGQIRGHGSIKKINSVSELVGLGGILQEDELKKRIGAEKTLDSLSETLESVFEQVGNIVYSSKVSHCQWQQEQEYQEEVERMVITICIRGLEEQLEKTLWDQNAQWYGNEDVCWFEKINEISFLRQELDAISKSLSNPESGVLHSHSSLEINGDVSNDKRTDHLHQKVLGNHVSSSVSLWEGNGKDGELVIPVPENLDPQQLIHMKKDELVNFFKVEMTKMKRNHDYKLQEMTEKYFSLKREYLKERGSSLPSRKDKEFDVLRKKIPDVILKLDRILVENEKVPLLSNNNDNLSILKDRLESLLSENRQLRDALSDRKKEVNQLSSQLSDAIMNISEQSLVEENLLRRVESLESVVEDAHIEATISWDVYNFLFRGAISQVKCMAEDSEMEQNIMKEIYDLILKDASCNMSHARKSGFEDSDLESLAMEGLCAIIFREAFTEAREKLHDLSMDAIEKERVLKMEVAEKENLQEQVLLVTSTVNEKEKLLNETAAALAREKEKLMAASQELDSARGWTNQHRMIISKCNEESSVLKTNLLQASEELEQHKVEICGLKTKLDQAMKELRESNGERSRLLVAAKENDNILSLVKANENEHRKQMESIIILVEGLSKGVAAFESRVGEHMERSSLRLESLSSQSSSLIQMVNKLKRKGLQYKQSLERRRSDLEKAETEVDLLGDEVEVLLGLLEKIYIALDHYSPILKHYPGIMEILKLVRRELSGECNKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VSG2</accession>
    <name>A0A0D2VSG2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G273300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB74110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VSG2"/>
    <dbReference type="Gramene" id="KJB74110">
        <property type="protein sequence ID" value="KJB74110"/>
        <property type="gene ID" value="B456_011G273300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37078:SF7">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37078">
        <property type="entry name" value="NODULE CYSTEINE-RICH (NCR) SECRETED PEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002269519" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB74110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8815" checksum="EB40B77E95DD936C" modified="2015-04-29" version="1">MAKHLVFFILLIVVLTFSNFKRVECGILKRVHRRGGYANLATLGVVCKCCDGEGGECRSSWDASYSCPKLKCLPWKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VVV9</accession>
    <name>A0A0D2VVV9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WRKY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_012G056800</name>
        <name evidence="9" type="ORF">Gorai_004200</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="KJB75770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB75770"/>
        <property type="gene ID" value="B456_012G056800"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="InterPro" id="IPR044810">
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        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 36-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WRKY TRANSCRIPTION FACTOR 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="WRKY" evidence="7">
        <location>
            <begin position="229"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="6">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0601007.1"/>
        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VY91</accession>
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        <lineage>
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    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZ85</accession>
    <name>A0A0D2VZ85_GOSRA</name>
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            <fullName evidence="6">TF-B3 domain-containing protein</fullName>
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        <name evidence="8" type="ORF">Gorai_004922</name>
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        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZ85"/>
    <dbReference type="Gramene" id="KJB77460">
        <property type="protein sequence ID" value="KJB77460"/>
        <property type="gene ID" value="B456_012G167500"/>
    </dbReference>
    <dbReference type="OMA" id="DQTETHF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10017">
        <property type="entry name" value="B3_DNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.330.10">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003340">
        <property type="entry name" value="B3_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015300">
        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02362">
        <property type="entry name" value="B3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101936">
        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TF-B3" evidence="6">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB77460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0601754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="145" mass="16885" checksum="CA8FD95AA4F892FD" modified="2015-04-29" version="1">MAIEKELFKKRLTKTDVEKRLSIPSRKKKCFLNFRGKHMAEFKVKDKHGKEWKFNCSTRKKDYPKPVLTSGWLLFVQWWNLAVGDEVKVYGKMDQAGEEHYRIEVAVATDSTADGTVNDDQTETHFFEFISLKPDLNVGKSKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W6A1</accession>
    <name>A0A0D2W6A1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">galactinol--sucrose galactosyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_013G149200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Transglycosidase operating by a ping-pong reaction mechanism. Involved in the synthesis of raffinose, a major soluble carbohydrate in seeds, roots and tubers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.82" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB81540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W6A1"/>
    <dbReference type="STRING" id="29730.A0A0D2W6A1"/>
    <dbReference type="Gramene" id="KJB81540">
        <property type="protein sequence ID" value="KJB81540"/>
        <property type="gene ID" value="B456_013G149200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783700"/>
    <dbReference type="eggNOG" id="ENOG502QPVE">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FRYHHAN"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000129">
        <property type="entry name" value="Probable galactinol--sucrose galactosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF29">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB81540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="749" mass="83125" checksum="7C4AC2DA26136EA6" modified="2015-04-29" version="1">MTVGAGICVSDDGKLMVLGNCVLHDVPDNIVVLPASGDALANGAFIGVVSDKTGCRRVFPVGKLQGLRFMCVFRFKMWWMTQRMGACGQDIPFETQFLIVEARDGSGNGDDSAVYVVFLPILEGDFRAVLQGNERNELEICLESGDPAVDEFEGNHLVFVAAGSDPFDVITNAVKSVEKHLQTFSHRERKKMPDMLNWFGWCTWDAFYTNVTSESLKEGLESLEKGGIHPKFLIIDDGWQSVAMDSHGTEFRADNAANFANRLTNIKENHKFQKDGKEGHRVEDPALGLCHIVTEIKQKHALKYAYVWHAITGYWGGVRPDVTEMEHYESKVVYPISSPGVESNEPDQALDSITKNGLRLVNPEKVFNFYDELHAYLATAGIDGVKVDVQNILETLGAGNGGRVKLARKYHQALEASIARNFANNDIISCMSHNTDGLYSAKRTAVIRASDDFWPRDPASHTIHIASVAYNTVFLGEFMQPDWDMFHSLHPMAEYHGAARAVGGCAIYVSDKPGQHDFDLLKKLVLPDGSILRAKLPGRPTRDCLFSDPARDGKSLLKIWNLNEFTGVMGVFNCQGAGWCRVGKTNVIHDKQPDTITGYVRARDVDYLPKVAGDEWNGDSIIYSHLGGELTYLPNDATMPITLKARQYEVFTVVPVKILSNGCKFAPIGLIKMFNSGGAIKDFRYHHANIDMKIRGCGVFGAYSSTRPKRITVETEEVSFEYEDASGLVTLSLRVPEEELYVWSIAIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W8R7</accession>
    <name>A0A0D2W8R7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_013G232500</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="4 9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W8R7"/>
    <dbReference type="SMR" id="A0A0D2W8R7"/>
    <dbReference type="STRING" id="29730.A0A0D2W8R7"/>
    <dbReference type="Gramene" id="KJB83165">
        <property type="protein sequence ID" value="KJB83165"/>
        <property type="gene ID" value="B456_013G232500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781332"/>
    <dbReference type="eggNOG" id="KOG1757">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVHICFF"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="17"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="104"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB83165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="134" mass="14358" checksum="6E1527802942DDB1" modified="2015-04-29" version="1">MSGKGAKGLIMGKNSASNKDKDKKKPISRSSRAGLQFPVGRIHRLLKLRTTAHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDTLIKGTIAGGGVIPHIHKSLINKTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2013-06-26" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>M9ZA63</accession>
    <name>M9ZA63_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">3-ketoacyl-CoA synthase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">KCS7</name>
        <name evidence="15" type="ORF">B456_009G021000</name>
        <name evidence="16" type="ORF">Gorai_010907</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2012-11" db="EMBL/GenBank/DDBJ databases">
            <title>Functional analysis and molecular cloning of Gossypium raimondii KCS genes.</title>
            <authorList>
                <person name="Xiao G.-H."/>
                <person name="Li Q."/>
                <person name="Zhu Y.-X."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="16 18" key="3">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="KC160457">
        <property type="protein sequence ID" value="AGK29991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0593984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="M9ZA63"/>
    <dbReference type="STRING" id="29730.M9ZA63"/>
    <dbReference type="GeneID" id="105767937"/>
    <dbReference type="Gramene" id="KJB54111">
        <property type="protein sequence ID" value="KJB54111"/>
        <property type="gene ID" value="B456_009G021000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB54112">
        <property type="protein sequence ID" value="KJB54112"/>
        <property type="gene ID" value="B456_009G021000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767937"/>
    <dbReference type="eggNOG" id="ENOG502QPKZ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DIWEHLQ"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00831">
        <property type="entry name" value="CHS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000028">
        <property type="entry name" value="3-ketoacyl-CoA synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012392">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013601">
        <property type="entry name" value="FAE1_typ3_polyketide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31561">
        <property type="entry name" value="3-KETOACYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08392">
        <property type="entry name" value="FAE1_CUT1_RppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036417">
        <property type="entry name" value="3-ktacl-CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="FAE" evidence="12">
        <location>
            <begin position="93"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-terminal" evidence="13">
        <location>
            <begin position="399"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AGK29991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB54111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0593984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="510" mass="57638" checksum="B09F7F7544A3359D" modified="2013-06-26" version="1">MADSKPDQPLMPSSSSNLPDFKKSVKLKYVKLGYHYLITHGMYLFLTPLVVVIAAQLSTFSVKDLFDLWEHLQYNLISVIICSALLVFLSTLYFLTRPRPVYLVNFACYKPEESRKCTKRMFVDQSQLTGTFTEENLQFQRRILERSGLGDSTYLPEAVLNIPPNPSMHEARKEAEAVMFGAIDELLAKTSVKPKDIGILIVNCSLFNPTPSLSAMVINHYKLRGNIQSYNLGGMGCSAGLISIDLAKHLLQVHPNSYALVISMENITLNWYFGNDRSKLVSNCLFRMGGAAILLSNKWSDERRSKYQLVHTVRTHKGSDDKCFSCVTQEEDSIGKIGVTLSKDLMAVAGDALKTNITTLGPLVLPMSEQLLFFATLVGKKLFKMKVKPYIPDFKLAFEHFCIHAGGRAVLDELEKNLQLSEWHMEPSRMTLYRFGNTSSSSLWYELAYSEAKGRIRRGDRTWQIAFGSGFKCNSAVWKALRTINPVKEKNPWMDEIHNFPVDVPRVSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LWL8</accession>
    <name>A0A0D2LWL8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_001G089200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Constitutively interacts with CASP4; required for the localization of procaspase 4 to the ER.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM214 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2LWL8"/>
    <dbReference type="STRING" id="29730.A0A0D2LWL8"/>
    <dbReference type="Gramene" id="KJB08557">
        <property type="protein sequence ID" value="KJB08557"/>
        <property type="gene ID" value="B456_001G089200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4467">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WMKILRE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019308">
        <property type="entry name" value="TMEM214"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13448:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10151">
        <property type="entry name" value="TMEM214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB08557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="589" mass="65068" checksum="F6DA2D5E55754772" modified="2015-04-29" version="1">MDENSAMIKQILREFENEDGKNDDFNEWQTVSYSKQNWKPSKPFPPGGFFDLYNGGVSSDIFSSIEKHSEDHRRRAAKAAAAAEVEAAVSSAVSNGVNVDDKDDSDTDGVEENGAVEIKKVKPKKPKKPNVTVAEAASKIEAGDLSAFLIDITRSYETQQDIQLMRFADYFGRAFPSVSAAQFPWLKLFKESTVSKLVDIPLSNVPEDVYKTSVDWLNRRSLDALVSFVLWSLDNIQADLASHQVATKGSKKVPPASTIKVAIFVVLSMALRRKPDVLISLAPKLREDPKYQGQDKLPITVWMIAQVAIDNLKTLIFLPAQIILLGDLAVGLYMWVHILLPMLSGKSSCNPQSRDLILQLVERIISCPKARPILVNGAVRKGDRLVPPSALDILMKLTFPAPSARATERFEAIYPTLKKVALVGSPGSKAMKQVAQQILSYAVKAAGEDPPELSKEASDVFIWCLTQNPECYKQHDVLYLDNLDASVAVLRKLANEWKEHSAKHSTVDPLREILKSFRQKNEKAEIDVDASLKEADKYCRLLLGHFSKGHGCLKGALFASIALVAGVAVMSQNVQFLSLDKLSAMFNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M7P2</accession>
    <name>A0A0D2M7P2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable bifunctional methylthioribulose-1-phosphate dehydratase/enolase-phosphatase E1</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Methylthioribulose-1-phosphate dehydratase</fullName>
                <shortName evidence="9">MTRu-1-P dehydratase</shortName>
                <ecNumber evidence="9">4.2.1.109</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Enolase-phosphatase E1</fullName>
                <ecNumber evidence="9">3.1.3.77</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="9">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G069300</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="9"/>
    <dbReference type="EC" id="3.1.3.77" evidence="9"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M7P2"/>
    <dbReference type="STRING" id="29730.A0A0D2M7P2"/>
    <dbReference type="Gramene" id="KJB13337">
        <property type="protein sequence ID" value="KJB13337"/>
        <property type="gene ID" value="B456_002G069300"/>
    </dbReference>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>A0A0D2N4E5</accession>
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        </lineage>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB26987.1"/>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="NAC_dom_sf"/>
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        <property type="entry name" value="NAC (NO APICAL MERISTEM) DOMAIN TRANSCRIPTIONAL REGULATOR SUPERFAMILY PROTEIN"/>
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    </dbReference>
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        <location>
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            <end position="164"/>
        </location>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB26987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="288" mass="32860" checksum="5BB1FC65E40EAAD1" modified="2015-04-29" version="1">MSMVRGTTPTVDEDVPLPGFRFHPTDEELVGFYLRRKVDNKPLTIELIKEIDIYKYDPSDLPKTGMVGENELYFFCRRGRKYRNSVRPNRVTESGFWKATGIDKPVFSVEGGEAIGLKKTLVYYRGSGGKGTKTDWMMHEFRLPNPTMTAQDAEVWTICRFFKRHRKIKQDWRQGAAKPASTGNGNGVQGYESGSVGSSSHENYITLGSQNVENYDDDDGEMVMDHMMNDGSCRREWYHGEMQCMASSSSPSSSFSTENDFFTNANWDELKSIVDLDLDPFHFAKNHF</sequence>
</entry>
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            <fullName evidence="4">Dirigent protein</fullName>
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        <name evidence="6" type="ORF">Gorai_020516</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Dirigent proteins impart stereoselectivity on the phenoxy radical-coupling reaction, yielding optically active lignans from two molecules of coniferyl alcohol in the biosynthesis of lignans, flavonolignans, and alkaloids and thus plays a central role in plant secondary metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
            <location evidence="4">Extracellular space</location>
            <location evidence="4">Apoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the plant dirigent protein family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB07743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="MBA0578218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_001G042200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770287"/>
    <dbReference type="eggNOG" id="ENOG502RXRA">
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        <property type="component" value="Chromosome 1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048046">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="P:phenylpropanoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Allene oxide cyclase-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363099"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB07743.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="MBA0578218.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="188" mass="20873" checksum="9CC13CAF6CB6818A" modified="2015-04-29" version="1">MEEQLIFAWAMIFCIAIAPVYGEYYSKTVTPSSKVEKVTNLHFFLHDTLSGEHPSAVLVAHANLTRKDHSPVPFGSLFAIDDRLRVGPEPTSKIIGNAQGLYLSSSQDASKFTIVLYADFAFTTGKFKGSSFSIFSRNPVTEAKREVAIVGGRGRFRMARGFAHIKTSYFNATTGDAILDYKVTLYHY</sequence>
</entry>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">B456_005G090700</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9S0"/>
    <dbReference type="Gramene" id="KJB29237">
        <property type="protein sequence ID" value="KJB29237"/>
        <property type="gene ID" value="B456_005G090700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QTFEINM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317:SF35">
        <property type="entry name" value="DUF4219 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35317">
        <property type="entry name" value="OS04G0629600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB29237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="94" mass="11076" checksum="8A1E7B8D2FB1B437" modified="2015-04-29" version="1">MLTTKFETLRIQESKTIGEFYVKLYDLTNQDFPLRSEYSNSKLVRKVLRSLPERFITKVTTIDEANDTNAIKINELIGTLQTFEINMERSRRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NDF1</accession>
    <name>A0A0D2NDF1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Cysteine-rich receptor-like protein kinase 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_005G156100</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NDF1"/>
    <dbReference type="STRING" id="29730.A0A0D2NDF1"/>
    <dbReference type="Gramene" id="KJB30707">
        <property type="protein sequence ID" value="KJB30707"/>
        <property type="gene ID" value="B456_005G156100"/>
    </dbReference>
    <dbReference type="OMA" id="CEDNTTN"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23509">
        <property type="entry name" value="Gnk2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000142">
        <property type="entry name" value="Cysteine-rich receptor-like protein kinase 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.430.20:FF:000003">
        <property type="entry name" value="Cysteine-rich RLK (RECEPTOR-like protein kinase) 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001019">
        <property type="entry name" value="G-type lectin S-receptor-like serine/threonine-protein kinase B120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.430.20">
        <property type="entry name" value="Gnk2 domain, C-X8-C-X2-C motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002902">
        <property type="entry name" value="GNK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038408">
        <property type="entry name" value="GNK2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002:SF1050">
        <property type="entry name" value="CYSTEINE-RICH RECEPTOR-LIKE PROTEIN KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27002">
        <property type="entry name" value="RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD1-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01657">
        <property type="entry name" value="Stress-antifung"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51473">
        <property type="entry name" value="GNK2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 18" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002247977" description="Cysteine-rich receptor-like protein kinase 25" evidence="18">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Gnk2-homologous" evidence="20">
        <location>
            <begin position="94"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="278"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="23">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="498" mass="55692" checksum="702C12BA123E6821" modified="2015-04-29" version="1" fragment="single">HLWDHLNLLLSFLTSNAHRIDGFYNTTVGQQPPDRIYGLFLCRGDVTPDVCRDCVAAAARNATSLCPVEKNSVIWYDKCMLRYSNESIFSTMETRPGGTVWDNDTFTEEEDFVDIVASLVKDVASEVADAPMGAKKFATKEVNLSGSQKLYSLAQCTPDISDVACNLCLESAITEFSDCCRQKEKATRASSLLPSCNVQYGLTPFYNKTAGEVSRSKPSPLPPRDSGKGKSSSQTIIYIIVPTVGFLVLLSTFCYCILRRKARMKPYLLKDQKATDNFSDANMIGVGGFGSVYKGTLSNGQQIAVKRLSRSSKQAAEEFKNEVALVAKLQHRNLVRLLGFCVEREERMLIYEFVPNKSLDCFLFHTEKQKQLDWPTRLKIVKGTVRGLLYLHTDSRLKIVHRDLKPSNILLDEDMNPKISDFGMARIVEENHNLEYTKKIVGTYGYIAPEYALHGIFSFKSDVYSYGVLTLEIVGGKTNTSFYNPESAESLLSYVGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGH5</accession>
    <name>A0A0D2NGH5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G0107001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="14" mass="1588" checksum="4CF2FCEE15A7EBC7" modified="2015-04-29" version="1" fragment="single">MEEGLELVFHILAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NQZ6</accession>
    <name>A0A0D2NQZ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Vacuolar protein sorting-associated protein 26A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_006G121700</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in vesicular protein sorting. Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport. The VPS29-VPS26-VPS35 subcomplex may be involved in recycling of specific cargos from endosome to the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the retromer complex which consists of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C), VPS5/17 (SNX1 or SNX2A or SNX2B). Component of a retromer subcomplex consisting of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus</location>
            <location evidence="4">trans-Golgi network membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the VPS26 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NQZ6"/>
    <dbReference type="STRING" id="29730.A0A0D2NQZ6"/>
    <dbReference type="Gramene" id="KJB35602">
        <property type="protein sequence ID" value="KJB35602"/>
        <property type="gene ID" value="B456_006G121700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3063">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000006">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000012">
        <property type="entry name" value="vacuolar protein sorting-associated protein 26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00056169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00064408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB35602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="35364" checksum="0BFEFAF55276C332" modified="2015-04-29" version="1">MNYLVGAFKPPCNIFISFTDGRSRKQVPLKKENGKTVMVALFQSQENIVGEVVVIEPIHGKKVEHNGVKIELLGQIELYFDRGNFYDFTSLVRELDVPGELYERKTYPFEFSTVEMPYESYNGVNVRLRYILKVTISRNYVSNIVEYQDFVVRNYTPPPSINNSIKMEVGIEDCLHIEFEYSKSKYHLKDVIIGKIYFLLVRIKLKNMELEIRRRESTGSGPNTYVETETLAKFELMDGAPVRGESIPIRLFLSPYELTPTYRNINNKFSVKYYLNLVLVDEEDRRYFKQQEITMYRNLEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NUB4</accession>
    <name>A0A0D2NUB4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PRONE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_006G178300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NUB4"/>
    <dbReference type="STRING" id="29730.A0A0D2NUB4"/>
    <dbReference type="Gramene" id="KJB36827">
        <property type="protein sequence ID" value="KJB36827"/>
        <property type="gene ID" value="B456_006G178300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799895"/>
    <dbReference type="eggNOG" id="ENOG502QPIY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1053009at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000004">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2010:FF:000001">
        <property type="entry name" value="Rop guanine nucleotide exchange factor 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2010">
        <property type="entry name" value="PRONE domain, subdomain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005512">
        <property type="entry name" value="PRONE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038937">
        <property type="entry name" value="RopGEF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33101:SF14">
        <property type="entry name" value="ROP GUANINE NUCLEOTIDE EXCHANGE FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03759">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51334">
        <property type="entry name" value="PRONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRONE" evidence="4">
        <location>
            <begin position="164"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="94"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB36827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="667" mass="74593" checksum="2AB83A8D2F5DE3C0" modified="2015-04-29" version="1">MPAPKLKAKSFWVSKSFRSLCYKAIESNVCCSQRLEYSGMIVNNSVFCPSPGPFEEQQTEMEGLVEKEGSFKEKNESFSENGVQMGTFAELLEDKGRESSSSSDFLTSETTGHEEEHSHSSSEEGSASPPSLGWPVKENAGTEDCTSTNCSEDGKKTPLDNRKLEKQGSTISEIELMKERFAKLLLGEDMSGCGNGVCTALAISNAITNLCATLFGQIWRLEPVPPEKKAMWRREMEWLLSVSDHIVELIPSWQTFPDGSKLEVMTCRPRSDLYINLPALRKLDNMLLEILDTFTDTEFWYVDQGILAPEADGSTSFRKAFQRQEEKWWLPVSRVPPGGLHENSRKQLQHKRDCTNQILKAAMAINSITLADMEVPESYLESLPKNSRTSLGDLIYRYISSDMFTPDCLLDCLDLSSEHQAIEIANRVEASIYLWRKKSNSKPISTNRSSSKSSWDLVKDLMIDSDKREMLADRAQSLLLCLKQRFPGLPQTTLDMSKIQYNKDVGKSIIESYSRVLESLAFNIIARIDDVLYVDDLTKHSDQFSSLSRIGLIGQKSLSVPYSVPFPSTPYRTAFSTPNFSPAQLATPAKGDRSPFLSSSKVPQRGMGVTKVLTDYLNIDLRPKEYSNPDEGTESGSTITQEASVSFECLKEAVSLSILEPVPEKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NV90</accession>
    <name>A0A0D2NV90_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G022900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NV90"/>
    <dbReference type="STRING" id="29730.A0A0D2NV90"/>
    <dbReference type="Gramene" id="KJB17898">
        <property type="protein sequence ID" value="KJB17898"/>
        <property type="gene ID" value="B456_003G022900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787604"/>
    <dbReference type="eggNOG" id="KOG2659">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2415936at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="2">
        <location>
            <begin position="428"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB17898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="676" mass="75584" checksum="D4A95945782C36B6" modified="2015-04-29" version="1">MDSWPVNWEALDALIIDFAKSENLIEDSSPPSSPSLTSSYHSRLIIRQIRRSLEVGNIDAAIDILRVHAPFVLEDHRLLFRLQKLKFIELLRKGTRDDRIFAIDYLRKSLAPCALNAYPEAYEEFKHVLLAFIYDKDDQTSPVANEWAEKRRYEIAGLVSSVLRAHFHAYSPIFSMALRYLMSIHKVFCFRQGIVSPISYLTERLLLEERDFPALPPESLYEAQVFDEVDIQALAHAVELTRQGAIDSLRFAKGDLFQAFQNEICRMRLNDAMLDELVREYCVYRGIVEPGMQTSSESLKVNPPESGCCSSLDSSIDVDHSTAKHSNSETSATTDLSSMQGIDVELRFASEPTNNLEDCSPSGSHQSESSSLLRNRSKGAGERSKRKRWRGRHDDLDFISGVHFNRDGKQEVSTTISKGVECTSAEDKYEIVLQMKELASRGMAAEVVEEISTLDPDFFVQNPVLLFQLKQVEFLKLVGLGDHSGALRVACSHLGPLAARDPNLLKPLKETLLSLLRPNEEALVTGLPLHALATSLQVAFGKRLGIEEPQLMRIMRATLHTHSEWFKLQMCKDRFESLLRIDSLKENNTPVLTSLATSKSNIDSCSLGSSQATISSTTGVSDDSSSPNQASSQDAICDENAILKVMEFLALPRADAIHLLAQYNGNAETVIQQIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NX64</accession>
    <name>A0A0D2NX64_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G064400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NX64"/>
    <dbReference type="Gramene" id="KJB18642">
        <property type="protein sequence ID" value="KJB18642"/>
        <property type="gene ID" value="B456_003G064400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18643">
        <property type="protein sequence ID" value="KJB18643"/>
        <property type="gene ID" value="B456_003G064400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="10926" checksum="E29C26BB426425E3" modified="2015-04-29" version="1">MALFYRFKKLLWSLAMVGLTSIGTSSIQSNGLVRLYPRVARACAASFVFRGVKSNDKLMKLNLFLWISLIMLSIIDLSTKSDLSFLMTVRASPSTTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NYK2</accession>
    <name>A0A0D2NYK2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G090300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
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                <person name="Duke M.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Byers R."/>
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                <person name="Duke M.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="48"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB46632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0591529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="415" mass="46067" checksum="5FE3C928362C077F" modified="2015-04-29" version="1">MGACCSTEVKYKGRRHEEDDLEGKEEEGQQEEVTTTGHAGAIVRFQGSSSYTSMYTRKGKKGINQDAMTVWENFMGEKNVFFCAVFDGHGPSGHQVARHVCHTLPYKLSTVFKENDVAVGADKDWEASIIRAFEESDEDLILEESLDSYCSGTTAVTVIKQDEHLIISNLGDSRAILCTRDNENQLIPIQLTVDLKPSIPSEAERILKCGGRVFAMDEESNVPRVWMPDHDCPGLAMARAFGDFCLKDHGVIAIPQVSYRKLTSKDEFVVLATDGVWDVLTNNEVIRIVASVKKQSMAAKILVYYAVQAWRTRYPGSKVDDCAVVCLFLKKRPLLTRSLSDMSKNVASQLDGADSNLISKDRKTEEGETVINCDITVDPKALDELNRVKAFTKSSRLGSLNRRKTSKDFGGTEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PT42</accession>
    <name>A0A0D2PT42_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G178600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PT42"/>
    <dbReference type="STRING" id="29730.A0A0D2PT42"/>
    <dbReference type="Gramene" id="KJB09968">
        <property type="protein sequence ID" value="KJB09968"/>
        <property type="gene ID" value="B456_001G178600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB09969">
        <property type="protein sequence ID" value="KJB09969"/>
        <property type="gene ID" value="B456_001G178600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798060"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF126">
        <property type="entry name" value="INACTIVE LYSINE-SPECIFIC DEMETHYLASE JMJ19 ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjN" evidence="2">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="3">
        <location>
            <begin position="276"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB09969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="787" mass="89548" checksum="56E09C285E4C7EA0" modified="2015-04-29" version="1">MGAEHRKTPNETDSTARVSAPPGFAYLSSFFLKKVEHQEENMSFKTAEDFSTQNNVQVETSSNVFDVEKLKKSIGNRPWILNDKTDQITKEYQSAQPFKTTSRQCLGDTKGDVLEEAPVFRPSEEEFCDTLKYIESIRLKAEPYGLCRIIPPPSWQPPCLIKEKSIWEYSKFVAEIQQFDRSPAQSEMGKEPGLEFTLKRFKKHADDFIQHYFFSKDVGHVNCKREELSVESIEGEYRKIVENPSGKLEVLYGDLDTATFGSGFPMASNTGESCNKYIRSSWNLNNAPKLPGSLLSFESDKNSSVSVPHLRIGMCFSSLYWKIEEHHLYSISYLHVGSPKIWYGVPERYSFKFETLMKKYFPDLLGKPSKLHGVITRLSPFVFKSKGVPVYRIIQYPREFVLVFPGAYHSTFDCGFNVAEAVTFAPLDWLPHGQNAVALYQSHGRKTSISFDKLLIGAAREAVKAQWELILLKKNTIDNLRWKGYCGKNGILTETLKSRVKQEGMRREYLCSTFQTKRKDKNFNSTSKRECSICYFDLHLSAVHCSCSSDRYLCLNHAKRLCSCTWTEKIFLYKYEINELNMLVEAVEGTLSAVHAWAREDLNLGLRHYTPKEKSFREDEGKKAHKLQDAVTSYGNGLSAVSSIKAEIKARIQQLQCLHERKSKEEMVSTPSLPRMTQDDTSLLLREVMPEDLSSTSSESDDTTDLDLDDGGKGCVLSTLSSRPSPSQPASEREVTLSQRRRPPKRKVTLSELLKDNSSEHGTAKHFKSTSEGLPMSHPASKKRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PUZ1</accession>
    <name>A0A0D2PUZ1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G212800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PUZ1"/>
    <dbReference type="SMR" id="A0A0D2PUZ1"/>
    <dbReference type="STRING" id="29730.A0A0D2PUZ1"/>
    <dbReference type="Gramene" id="KJB10634">
        <property type="protein sequence ID" value="KJB10634"/>
        <property type="gene ID" value="B456_001G212800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB10635">
        <property type="protein sequence ID" value="KJB10635"/>
        <property type="gene ID" value="B456_001G212800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802071"/>
    <dbReference type="eggNOG" id="KOG2605">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YYGNSRA"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22751">
        <property type="entry name" value="OTU_plant_OTU9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.80:FF:000001">
        <property type="entry name" value="OTU domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF85">
        <property type="entry name" value="OVARIAN TUMOR DOMAIN-CONTAINING DEUBIQUITINATING ENZYME 11"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="88"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB10634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="227" mass="25970" checksum="042D95D7F10DF81B" modified="2015-04-29" version="1">MSEGQHNNASASSSSSLNSSFQDTEDDQAIASILAEEENLHYNAKLGKRLSHLDSIPHTPRVNGEIPDVNDATLDHERLSERLATYGLAELQMEGDGNCQFRALADQLFRNPDYHKHVRRQIVKQLKHSKKLYEGYVPMKYKGYLKKMKKSGEWGDHVTLQAAADRFGAKICLVTSFRDTCYIEIMPKQASPTREIWLSFWSEVHYNSLYASGDVPTRAPRRKHWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZA9</accession>
    <name>A0A0D2PZA9_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G1521002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB09606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB09606"/>
        <property type="gene ID" value="B456_001G1521002"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="38" mass="4276" checksum="F89EFA825B78DBA3" modified="2015-04-29" version="1" fragment="single">MLKQEIWKVLSKEVVSDSGDKLLLPCLYLPTTSFHAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PZL6</accession>
    <name>A0A0D2PZL6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G220600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Gramene" id="KJB51532">
        <property type="protein sequence ID" value="KJB51532"/>
        <property type="gene ID" value="B456_008G220600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502SFPF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNMEQVC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB51532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="59" mass="7080" checksum="C17E2F4D4FF0AAD5" modified="2015-04-29" version="1">MTGGNLEETERAKERANNMEQVCFWSNCYLFRVFFFQEVLDWRFLARGDFLLVSFVNCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q4N4</accession>
    <name>A0A0D2Q4N4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G115000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q4N4"/>
    <dbReference type="SMR" id="A0A0D2Q4N4"/>
    <dbReference type="STRING" id="29730.A0A0D2Q4N4"/>
    <dbReference type="Gramene" id="KJB53301">
        <property type="protein sequence ID" value="KJB53301"/>
        <property type="gene ID" value="B456_009G115000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53302">
        <property type="protein sequence ID" value="KJB53302"/>
        <property type="gene ID" value="B456_009G115000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB53304">
        <property type="protein sequence ID" value="KJB53304"/>
        <property type="gene ID" value="B456_009G115000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767978"/>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GAQPMIH"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018362">
        <property type="entry name" value="CCAAT-binding_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00686">
        <property type="entry name" value="NFYA_HAP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="203" mass="22487" checksum="F9276D3F0B018F9E" modified="2015-04-29" version="1">MTSSAHDLSDNNEVDEQKKHSEFSDHSSSPVTGLSPSSITTPNMPYTTPQHAVAPAAYPYPDPYYRSIFAPYDAQSYPPQPYGGQPMVHLQLMGIQQAGVPLPSDAVEEPVFVNAKQYHGILRRRQSRAKAESENKLAKSRKPYLHESRHLHALRRARGSGGRFLNSKKNENKQNEAAPSDKSQSNINLNSDKNELASTEGNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q9Z3</accession>
    <name>A0A0D2Q9Z3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G057900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2Q9Z3"/>
    <dbReference type="Gramene" id="KJB55002">
        <property type="protein sequence ID" value="KJB55002"/>
        <property type="gene ID" value="B456_009G057900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105767383"/>
    <dbReference type="eggNOG" id="ENOG502RYW2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CCKKTPE"/>
    <dbReference type="OrthoDB" id="1896025at2759"/>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373:SF31">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33373">
        <property type="entry name" value="OS07G0479600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB55002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="196" mass="22181" checksum="A1AE58DB809838F1" modified="2015-04-29" version="1">MNPRCCLLPQTERCFGKKPFCSFVFFSGAYLRALTHWLMDTFKAKCKALFSSRGCFGCFIAVDDPSKPLKIRGRKAKRSSCSEDFWNSSGCEMEHSGVQSQGSISSTNASNLDPSGSTSHPSEFVNHGLLLWSQTRQQWLGNNKSEKRVQPRQPTISWNTIYESLHGNYKSFPHPIPLPEMVDFLVDVWEQEGLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QFZ1</accession>
    <name>A0A0D2QFZ1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G072000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2QFZ1"/>
    <dbReference type="Gramene" id="KJB06270">
        <property type="protein sequence ID" value="KJB06270"/>
        <property type="gene ID" value="B456_001G072000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1508">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="27"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB06270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="274" mass="32037" checksum="835531B3B63D7C54" modified="2015-04-29" version="1">MVADKGKKVKLTEKGEEENSEQIDKDLVLSIEKLQEIQDELEKINEEASEEVLEVEQKYNEVRRPVYDTRKDIIKKIPDFWLTAFLSHPALGDLLTEEDQEIFKHITSLEVEDFKDLKSGYSITFNFNPNPYFEDSKLTKTFTFHDEGTKITATQIKWKEGMGLPNGVNHEKKGYKRQLAEESFFTWFTDAHQKDDMDEIHDEVAEIIKEDLWPNPLTYFNNEADEEDFDGDEEMMTRMMMMMMMMKMTIMITKFAAGLLIILVAYLALSKNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QI57</accession>
    <name>A0A0D2QI57_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Senescence regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G178300</name>
        <name evidence="4" type="ORF">Gorai_012120</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the senescence regulator S40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QI57"/>
    <dbReference type="STRING" id="29730.A0A0D2QI57"/>
    <dbReference type="Gramene" id="KJB57732">
        <property type="protein sequence ID" value="KJB57732"/>
        <property type="gene ID" value="B456_009G178300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB57733">
        <property type="protein sequence ID" value="KJB57733"/>
        <property type="gene ID" value="B456_009G178300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RXVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RWIAREN"/>
    <dbReference type="OrthoDB" id="1917735at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010150">
        <property type="term" value="P:leaf senescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007608">
        <property type="entry name" value="Senescence_reg_S40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525">
        <property type="entry name" value="EMB|CAB72159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46525:SF18">
        <property type="entry name" value="SENESCENCE REGULATOR S40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04520">
        <property type="entry name" value="Senescence_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB57732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0595243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24056" checksum="1A4E6739EF9B4CC6" modified="2015-04-29" version="1">MAKGRRLTTSRSERLLGNYGYGHSQGDSVVNEEAELGEEDVWSMVDNVADRGDGGSVDNSRSQWSPHADAESNGNGNFDMRGDRRLIPRGDRHVGGLSLAFEDSASTKPRIVHQFRGHDGVAAAASPRGHHMATSAPVNVPDWSKIYRVNSVEWIRDSDDGLDDAESEMVPPHEYLAREYARSKKSGGASVFEGVGRTLKGRDMRRVRDAVWSRTGFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QN16</accession>
    <name>A0A0D2QN16_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tyrosine-protein phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G097000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QN16"/>
    <dbReference type="STRING" id="29730.A0A0D2QN16"/>
    <dbReference type="Gramene" id="KJB08675">
        <property type="protein sequence ID" value="KJB08675"/>
        <property type="gene ID" value="B456_001G097000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790038"/>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KGWNLAQ"/>
    <dbReference type="OrthoDB" id="165342at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033549">
        <property type="term" value="F:MAP kinase phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009738">
        <property type="term" value="P:abscisic acid-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18534">
        <property type="entry name" value="DSP_plant_IBR5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000079">
        <property type="entry name" value="Protein-tyrosine-phosphatase IBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044212">
        <property type="entry name" value="IBR5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47244">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE IBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47244:SF1">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE IBR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="103"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB08675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29612" checksum="3080E1609896CD3B" modified="2015-04-29" version="1">MRKRERENPCGICGHYHKFEEGEVCGVCGHRAPVSSDKTSLQVSAFPSVILPDFLYLGSYDNASRSELLKTQGITRVLNTVPACQNLYKNSFTYHCLQDDKILQFDDAVQFLEQCERDKARVLVHCMSGKNKSPAIVIAYLMKSKGWRLQPSYQWVKERRSSVELSQDAYQQLQEYEQKLFGSCDNSNLAGAPSFNFGFSNPSDPLPLPVPIPAFNNLGATSIFARPPPFEVPPHGFTFGADRTQRSMSENLSNPSGSDIPMDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNW1</accession>
    <name>A0A0D2QNW1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G059000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB18546.1"/>
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        <property type="gene ID" value="B456_003G059000"/>
    </dbReference>
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        <property type="component" value="Chromosome 3"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
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        <location>
            <begin position="7"/>
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        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18546.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
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        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_004G013500"/>
    </dbReference>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
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    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L7"/>
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    </dbReference>
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        <property type="entry name" value="60S ribosomal protein L7"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL30"/>
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        </location>
    </feature>
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        <location>
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            <end position="135"/>
        </location>
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        <source>
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        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="28361" checksum="FA03680B9013A16F" modified="2015-04-29" version="1">MGEEVKAVIPESLLKKNKRNEEWELAKKQELEAAKKKKVENRKLIFNRAKQYAKEYEAQEKELIRLKREAKLKGGFYVDPEAKLLFIVRIRGINAMHPRTRKILQLLRLRQIFNGVFLKVNKATMNMLHLVEPYVTYGYPNLKSVKELIYKRGFGKLNKQRVALTDNAIVEQALGKYGIICVEDLIHEIMTVGPHFKEANNFLWPFKLKAPLGGLKKKRNHYVEGGDAGNRENYINELIRRMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQG5</accession>
    <name>A0A0D2QQG5_GOSRA</name>
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            <fullName evidence="3">protein disulfide-isomerase</fullName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_001G143100</name>
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        <lineage>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the protein disulfide isomerase family.</text>
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    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QQG5"/>
    <dbReference type="Gramene" id="KJB09450">
        <property type="protein sequence ID" value="KJB09450"/>
        <property type="gene ID" value="B456_001G143100"/>
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    <dbReference type="KEGG" id="gra:105794736"/>
    <dbReference type="eggNOG" id="KOG0191">
        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
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    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF17">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE LIKE 2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002249608" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="130"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB09450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="356" mass="39598" checksum="9F95163ED136B3F4" modified="2015-04-29" version="1">MEMLLAFGTLGLLFASSALADDVLVLTQQNFDKEVGHDRGALVEFYAPWCGHCKKLAPEFEKLGANFKRAKSVLIGKVDCDEHKSVCNKYDVQGYPTIQWFPKGSLEPKKYVGPRTAESLSEFVNSEGGTNVKIATLPSSVVVLNADNFNEIVLDETKDVLVEFYAPWCGHCKSLAPIYEKVATAFKLEEDVVISNLDVDKYTDVAEKYGVSGYPTLKLFPKGNKAGEDYRGERELDDFVSFINEKCGTSRDTKGQLTSKAGILPSLDTLVKEFVSASNDDKKTVLSKLEQEVEKLKGSSARYGKIYLKAAKSCLEKGTDYPKEEIERLQRILDKSISQAKTDEFTLKRNILSTFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQK3</accession>
    <name>A0A0D2QQK3_GOSRA</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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        <name evidence="2" type="ORF">Gorai_013023</name>
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    <organism evidence="1 3">
        <name type="scientific">Gossypium raimondii</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQK3"/>
    <dbReference type="SMR" id="A0A0D2QQK3"/>
    <dbReference type="Gramene" id="KJB60332">
        <property type="protein sequence ID" value="KJB60332"/>
        <property type="gene ID" value="B456_009G300600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771317"/>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nakanori"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36482:SF6">
        <property type="entry name" value="JASMONATE-INDUCED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36482">
        <property type="entry name" value="OSJNBA0024J22.15 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21230">
        <property type="entry name" value="Nakanori"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB60332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0596192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="146" mass="16663" checksum="F8085B3681CA7579" modified="2015-04-29" version="1">MASFQMLKRVQKSTTGKLWNSSSQTLTLTDKKVWQGSHYTEFPETIQDGDNGEFTHDADEGEFSGSIVGLVYRRRDGTRWVIAWSNPLLGESKVFTDIQQQPIHWGQIKTNLDKRGKQKFKVSKFGYIASVEIDPFTVKASFELEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQY4</accession>
    <name>A0A0D2QQY4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G029500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
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            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QQY4"/>
    <dbReference type="Gramene" id="KJB22099">
        <property type="protein sequence ID" value="KJB22099"/>
        <property type="gene ID" value="B456_004G029500"/>
    </dbReference>
    <dbReference type="OMA" id="HIGPVAE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="138" mass="13954" checksum="CAB81718D6B0CD07" modified="2015-04-29" version="1">MAPTSPPVVEPPKQSSVLPGPSPWPAHSPKHIGPVAEPALAPSSPSPLAEPPKQSSPGPAYSPKHHGPVAGPVLAPTYTPPPAHVAEPPKQSSASPAHSPKHHAPTLAPTYPPPPPPKQSPPPLPSTSPQDSTSSPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QT01</accession>
    <name>A0A0D2QT01_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G343900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QT01"/>
    <dbReference type="STRING" id="29730.A0A0D2QT01"/>
    <dbReference type="Gramene" id="KJB61157">
        <property type="protein sequence ID" value="KJB61157"/>
        <property type="gene ID" value="B456_009G343900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF780">
        <property type="entry name" value="MYOSIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB61157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="80" mass="9025" checksum="969F09BEF66B9157" modified="2015-04-29" version="1">MQYLAVLGGGSGIEYEILKTNPILEAFGNAKTLRNDNSSLFVYGLWYMQQFIMCIFRLLVKDVVRLSCVVDPLSCTCCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QT22</accession>
    <name>A0A0D2QT22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G344800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QT22"/>
    <dbReference type="STRING" id="29730.A0A0D2QT22"/>
    <dbReference type="Gramene" id="KJB61182">
        <property type="protein sequence ID" value="KJB61182"/>
        <property type="gene ID" value="B456_009G344800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HPAYLKM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000019">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000057">
        <property type="entry name" value="Glycosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035595">
        <property type="entry name" value="UDP_glycos_trans_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF727">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 74B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00375">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB61182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="461" mass="51676" checksum="B660BB2F7E42B490" modified="2015-04-29" version="1">MEDKQMKGHVLVLPYPSQGHINPLLQFAKRLASKGVKATLTTTHYTLNSISAAHIGVEPISDGFDEGGFSQAGNVDFYLKSFRDHGSRTLAELIQKFSNSATPVNCVVYDSFLPWALDVAKQHGIYGAAFFTNSATVCSIFAHIHHGLLTLPLTPETTPLLLPGLPPLYFPDLPSFLRFPDSYPAYLAMKLSQYSNLNQADWVFSNTFEELEGKEARGVSEIWPAKLIGPMVPSAYLDERIKGDRGYGSSLWKPLSEECIEWLETKPSNSVVYVSFGSMVSLSEEQIAELAWGLKESNMYFLWVVRDSEQQKLPKWFLDSVQEKGKVVTWCNQLEMLAHRTVGCFVTHCGWNSTLEGLSLGVPMIGVPKWTDQLTDAKFVEEIWEIGVRAKEDEVGVVRKDELLRCLKEVMEGDKSKEIKRNANKWRDSAMKTITEGGSSDKCIDEFVQHLMASYQNLNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QYZ0</accession>
    <name>A0A0D2QYZ0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Epidermal patterning factor-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_002G017900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Controls stomatal patterning.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the plant cysteine rich small secretory peptide family. Epidermal patterning factor subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QYZ0"/>
    <dbReference type="STRING" id="29730.A0A0D2QYZ0"/>
    <dbReference type="Gramene" id="KJB12440">
        <property type="protein sequence ID" value="KJB12440"/>
        <property type="gene ID" value="B456_002G017900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787143"/>
    <dbReference type="eggNOG" id="ENOG502S3VT">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KAPPHGD"/>
    <dbReference type="OrthoDB" id="771316at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010052">
        <property type="term" value="P:guard cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039455">
        <property type="entry name" value="EPFL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109">
        <property type="entry name" value="EPIDERMAL PATTERNING FACTOR-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33109:SF41">
        <property type="entry name" value="PROTEIN EPIDERMAL PATTERNING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17181">
        <property type="entry name" value="EPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="141" mass="15536" checksum="57A580128C81D01D" modified="2015-04-29" version="1">MKEAMKIPAVTIAAIAIILFCYIPVMASARHVKAPPHGDHNKHYEEHDSRPSTRQGSMLGAKMVSNKLVDSNWETRSLPQRKRADTLKISGSSLPDCSHACMSCTPCLLVIVSFVCSSLEEAETCPMAYKCMCNHKSYPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R0V0</accession>
    <name>A0A0D2R0V0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_004G196700</name>
        <name evidence="11" type="ORF">Gorai_015150</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R0V0"/>
    <dbReference type="STRING" id="29730.A0A0D2R0V0"/>
    <dbReference type="Gramene" id="KJB25544">
        <property type="protein sequence ID" value="KJB25544"/>
        <property type="gene ID" value="B456_004G196700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792050"/>
    <dbReference type="eggNOG" id="ENOG502QW5S">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RYHDPPS"/>
    <dbReference type="OrthoDB" id="1932364at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051032">
        <property type="entry name" value="AP2/ERF_TF_ERF_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31985:SF298">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Reddy U.K."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
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        <lineage>
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    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NLE1/RSA4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R6C3"/>
    <dbReference type="STRING" id="29730.A0A0D2R6C3"/>
    <dbReference type="Gramene" id="KJB24981">
        <property type="protein sequence ID" value="KJB24981"/>
        <property type="gene ID" value="B456_004G170600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791754"/>
    <dbReference type="eggNOG" id="KOG0271">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000092">
        <property type="entry name" value="notchless protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="14"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="192"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="359"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="443"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB24981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0584148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="476" mass="52662" checksum="5F6789E1F81E9B43" modified="2015-04-29" version="1">MEVETEQGETGKSVMCVLTDPEGTTLGGTMYLPQNVGPIQLQQIVNTLLKNEEKLPYAFYISNQELLVPLGNYLEKNKVSMEKTLSIVYQPQAVFRIRPVNRCSATIAGHTEAVLSVAFSPDGRQLASGSGDTTVRLWDLNTQTPMFTCTGHKNWVLCIAWSPDGKHLVSGSKSGELQCWDPQTGKPAGNPLTGHKKWITGISWEPVHLNAPCRRFVSASKDGDARIWDISLKKCVICLSGHTLAVTCVKWGGDGVIYTGSQDCTIKVWETSQGKLIRELKGHGHWVNSLALSTEYVLRTGAFDHTGKQYSSPEEMKKVALERYNKMKGNAPERLVSGSDDFTLFLWEPAVSKHHKVRMTGHQQLVNHVYFSPDGQWVASASFDKSVKLWNGTTGEFVAAFRGHVGPVYQISWSADSRLLLSGSKDSTLKVWDIRTKKLKQDLPGHADEVFAVDWSPDGEKVASGGKDRVLKLWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R7V6</accession>
    <name>A0A0D2R7V6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G026000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R7V6"/>
    <dbReference type="Gramene" id="KJB47428">
        <property type="protein sequence ID" value="KJB47428"/>
        <property type="gene ID" value="B456_008G026000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0157">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YVCRREI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24296">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250325" description="Cytochrome P450" evidence="8">
        <location>
            <begin position="20"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB47428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42761" checksum="60574C1DD907CE15" modified="2015-04-29" version="1">MVFGIIFLCFLYRFIDNNGLPRNWPFVVMIPTLLLNIHRPDGKVAQILRRSNGTFFYRGLWFTNTSFLATSDPENVHYILSSNSSVYLKGSEWLKHFDIFGEALFNSDGEASKRHGKAFHAFFNHPQIRQSLSKVLHQRIEEALVEVLEYVCRREIVVNLQDLFARHAFDIGCIMGMGFNPGPTLKDSLMRDNIIQFLFGSEGTYGLTREEIKRHLSMKQMEGGLHIPSNYDELSKLTYLHAAVCETLRLYPLVPFEFRSCTKPDFLPSGHRVDRSTRVLIGIHAMGRMESLWGEDCYELKPERESPSKFCSFLAGPRICPGKEVSFLVMKATVAAIMHSYNVDVLEGQNISSKNSVLCKMKKGLMVGVKKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RHD6</accession>
    <name>A0A0D2RHD6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CA-responsive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G059300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RHD6"/>
    <dbReference type="STRING" id="29730.A0A0D2RHD6"/>
    <dbReference type="Gramene" id="KJB18539">
        <property type="protein sequence ID" value="KJB18539"/>
        <property type="gene ID" value="B456_003G059300"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18540">
        <property type="protein sequence ID" value="KJB18540"/>
        <property type="gene ID" value="B456_003G059300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0409">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SHKNAQT"/>
    <dbReference type="OrthoDB" id="1925033at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35991">
        <property type="entry name" value="CA-RESPONSIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35991:SF1">
        <property type="entry name" value="CA-RESPONSIVE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB18540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="37811" checksum="EB8DF970D085E878" modified="2015-04-29" version="1">MFFICFLFSFALSFLFFLFSFYYKKRLHKQQHPQDEQGKSQNEPALSNPSLSHKNAQTRESDSTHFPHSLLLEILPPDSTQWADLFTGESHPREETRPVGSVGEGDLFESQSAKKKKKRGKKKRLDSKGEEENEEDRKKREEPGQSCSGSRVKPQLVCLYPFTSTSSATQRKIKQQYDQLVKCHGNKGLTLAQVGEFANCLIEARNDLQHKSEVIKRKFTITKALLFKADRSSFDRLRQQIYKLEMEQKRLEEDAFVYNWLQEQLKLSPAYKKMLEIGACMELKAKSGEQMEGADTEISDISFEELLAQEKKDSFWQKNGNSRLISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RIL7</accession>
    <name>A0A0D2RIL7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G075600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RIL7"/>
    <dbReference type="STRING" id="29730.A0A0D2RIL7"/>
    <dbReference type="Gramene" id="KJB18930">
        <property type="protein sequence ID" value="KJB18930"/>
        <property type="gene ID" value="B456_003G075600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105788179"/>
    <dbReference type="eggNOG" id="KOG0584">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YEESKTC"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13983">
        <property type="entry name" value="STKc_WNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000075">
        <property type="entry name" value="Probable serine/threonine-protein kinase WNK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000046">
        <property type="entry name" value="probable serine/threonine-protein kinase WNK9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024678">
        <property type="entry name" value="Kinase_OSR1/WNK_CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12202">
        <property type="entry name" value="OSR1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB18930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="612" mass="69198" checksum="B364DE635E3BD4D1" modified="2015-04-29" version="1">MEAADGCDFAEKDPSGRYVRYDEILGKGAFKTVFKGFDEADGIEVAWNQVNIEDVLQTSEQLERLYSEVHLLKSLKHENIMKFYNSWVDDKNNSINMITELFTSGSLRQYRKKHKNVDLKAIKNWSRQILRGLHYLHSHNPPIIHRDLKCDNIFVNGNNGEVKIGDLGLATVMQQPTAQSVIGTPEFMAPELYDEEYNELVDIYSFGLCMLEMVTCDYPYNECKNPAQIYKKVSSGIKPASLGKVNDPQVKQFIEKCLLPASIRLPAAELLKDPFLLAETAKDVRGGPLQLPNVMPQLVNLIQPEPHPMDIVHPMDIDPNCKKLTKSINAAPRSSTLELQCFIENNEFRLKGEKNDDHTISLTLRIADRYGRARNIHFSFYLGSDTAISITEEMVEQLDLSNEDIIAIAELIDSMILQLVPYWKPSSGSLSDVTIKTVSEQGVFSELAVVKCQDTQESLSSDISTECDGVVASDGSNNKLMGSSGYSNGEYHTDSRTYDFGLDIECVYNHFGHKEVSDEENRCESFVINDSVNYSDTSYLMDSCSFASQDMSLSSICSMSVEDKDKFEELKFELDAINLQYQQCFQELMRLKNAAMENAKNRWITKKKVSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKA3</accession>
    <name>A0A0D2RKA3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_008G224500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKA3"/>
    <dbReference type="STRING" id="29730.A0A0D2RKA3"/>
    <dbReference type="Gramene" id="KJB51608">
        <property type="protein sequence ID" value="KJB51608"/>
        <property type="gene ID" value="B456_008G224500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1246">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141052">
        <property type="term" value="F:histone H3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="entry name" value="Lysine-specific demethylase isoform A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="JmjC_dom"/>
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        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjN" evidence="9">
        <location>
            <begin position="102"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="JmjC" evidence="10">
        <location>
            <begin position="249"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="803"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51183"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB51608.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="96514" checksum="0EECE801E5F62063" modified="2015-04-29" version="1">MVEGRVRLSKKVKNGLEFLKHKRLQRIKSESSSGTSYLINMMARSGGDALRISASCGIRLQGNAGSFSRSNDASCENDVFSKHKVDKFDTSDLEWTEKIPECPVYCPTKEEFEDPLVYLQKIAPEASRYGICKIVSPLVATVPAGAVLMKEKVGFKFSTRVQPFRLAEWDTDDKVTFFMSGINYTFRDFEKMANKVFGRRYYSAGCLSATYLEKEFWHEIAYGKTESVEYACDVEGSAFSSSPSDPLGSSKWNLERLSRLPKSTLRLLETAIPGVTDPMLYIGMLFSMFAWHVEDHYLYSINYHHCGASKTWYGIPGHAASKFEKVVKEHVYTNDILSADGEDGAFDVLLGKTTLFPPSILLKHDVSVYKAVQKPGEFVITFPRAYHAGFSHGFNCGEAVNFAIGDWFPLGAIASLRYAHLNRAPLLPHEELLCKEAILLYTSLELEDLDYSLADLAAHHCIKVSFVKLMRFLHRALWSVMKSRACTSISPNYYRTIVCTLCKRDCYVAFINCSCNGHPVCLRHDIRSLHFPCGSYRYLFLRDDVAEMEAAAKKFEQDDAISKEIEQQIENGDDLYLYPLSNKLQTDVEDGYFPYCEINVVLGPDFAAINTMDQPLEHISSMNHGKFQPETNLEQVGSSPKTQVQRVANQVSVNGERFPEEVSENAYELSVSCLSREDHRSIHQDNVHDPVSRSIVDENSDSSDSAIFRVKRPFSKVEKRFGNDTISSKNSEHQGFKRLKKLQHEGRCGRPVAYGSECCRNDEPNRNTNCSSDSKALENAVKDRLGRGTLPIPISIKYKKMGSEAGMSSGQREHHRNRFQQELGKSKRDSPSEMGPKRLKVRGPSPIHLGSESRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RPI3</accession>
    <name>A0A0D2RPI3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_006G031300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in environmental stress response.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2RPI3"/>
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        <property type="protein sequence ID" value="KJB33799"/>
        <property type="gene ID" value="B456_006G031300"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG3173">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
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        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF116">
        <property type="entry name" value="ZINC FINGER A20 AND AN1 DOMAIN-CONTAINING STRESS-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB33799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="116" mass="12881" checksum="061F8A85283F66BC" modified="2015-04-29" version="1">MSSSCHSLFRTILKLPIVVEAFKPHVGSSSTSIEQQLPVDVVVACSQQLEPKAANKCFICRMKVGLTGFKCRCENTFCGEYWYPKKHECSFDFKGVGCDAIAKANPIAKADKVERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUY7</accession>
    <name>A0A0D2RUY7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G005700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUY7"/>
    <dbReference type="Gramene" id="KJB33286">
        <property type="protein sequence ID" value="KJB33286"/>
        <property type="gene ID" value="B456_006G005700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4658">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766:SF70">
        <property type="entry name" value="DISEASE RESISTANCE PROTEIN RGA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36766">
        <property type="entry name" value="PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0611">Plant defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="3">
        <location>
            <begin position="186"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="822" mass="91984" checksum="38D2E546541ED756" modified="2015-04-29" version="1">MLENFIRDIPQNMNALINILKKKIGQAKRGKEQIKYLLVLDDVWSVEKWDELKNHLMGINKNGGNGVIVTTPLMASLMSHELELIAKEIAKQCRGVPLVANIIGETMSNIKMNPRAWLEIQKSDVQKNTCRNILTFKIHDSVHDLSLSVSKFDTLLESLQKILTAFTPKLYSLFSEIDVSKKLSKSFTRLKFLKFVCATNISLPKSTAKIYNLQTLRLLGLLSLTFLDKLENLISLKHLYFDRKELQPVNIGNLTCLQVLPIFFVGSKRGRSIKELGSLKELRGELKICDLGGLIIDFEGSNSGSSGYNSEEVMEGLKTHTNLQSLAVSNYQGESFPSWMLKPVGDSNTGLFLLNILIELKDIHVSLLEELDICDCPFLKNVPLTGQCSSLKKPYISKCKTLSKIRDGLSTSIYLKELDLKGCPNLSWIPDLEEFSSLQNLSIDSYKELEVLPITGGCSSLEKLSILGCESLSKIEDKLFSSTCLKELYLCHCSNLSSVPDLEECFSLKILSINSCKELKVLPVIGRYGLFTPSLQNLSIDSCNELEVLSLPGSKIGDGLSTCACLKELGLYNCPNLSSIPNLEGIFSLQSLSINSEGWSCLLPNMLRSNTPLFSLIIVNLLDLIWILDDGLGRLNFLGELAIGARNKELQEFPCLSSFQYLSASLRVLELTGWEKLKISRNKSLSRVVGKPLFFKSLIYQLQLPTALEDLNIWGFHEIEALLESFKNLSSLCCLRIWSCNKLMYLPSVDVMGSFSKLETIDNFMCHQLETRCEKESGPEWSKISHIPHISSYTVKTNGGSGRSFKSTRGLRQGDPLSHFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RVW5</accession>
    <name>A0A0D2RVW5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G073200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB55378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RVW5"/>
    <dbReference type="STRING" id="29730.A0A0D2RVW5"/>
    <dbReference type="Gramene" id="KJB55378">
        <property type="protein sequence ID" value="KJB55378"/>
        <property type="gene ID" value="B456_009G073200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RY48">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ESAFYCD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004158">
        <property type="entry name" value="DUF247_pln"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170:SF25">
        <property type="entry name" value="BNAA09G04570D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31170">
        <property type="entry name" value="BNAC04G53230D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03140">
        <property type="entry name" value="DUF247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB55378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="420" mass="49343" checksum="5144743E71BA0B6A" modified="2015-04-29" version="1">MFDMQKEDPYAALATSVRRELETLLPLPHKRCIFQVPDRLRRLNDKAYTPRVISIGPLHHGQQIFKPMEHYKRRFLRDFLVRTRVSVKDCVMIVKDREAKLRDCFAQIIELSSDDFVKMVLFDAIFIVELLFRYNFGELWNDHILGCPRMIHDIQLDLCMIENQVPFFILEDLFNLAMESAFYCDEFSIKNMVLKFGIWAWGPYVREENLQQDFSQVEHVVDLLWLCFQPTSFSFKTEIENFKIPSAMELQQAGVKLRPGSSKNLFDIRFDNGVLEIPQLLVMDRTKVIFRNLMAYEQHYCSRNYVTDYVTMISFLVKSPRDAQLLIKNGIIENCLKDSEEVSTLFKGLVEEVRISRKNFELAGVVEDMKAYCKSRWHRWNATLKQDYFNSPWRSLSIIAATLLLPLTLVQTICAVIQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RW67</accession>
    <name>A0A0D2RW67_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_006G140200</name>
        <name evidence="9" type="ORF">Gorai_000968</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 11" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">8</strain>
            <tissue evidence="9">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB36084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RW67"/>
    <dbReference type="STRING" id="29730.A0A0D2RW67"/>
    <dbReference type="Gramene" id="KJB36084">
        <property type="protein sequence ID" value="KJB36084"/>
        <property type="gene ID" value="B456_006G140200"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502R5PU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11393">
        <property type="entry name" value="bHLH_AtbHLH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor bHLH130 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045239">
        <property type="entry name" value="bHLH95_bHLH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045843">
        <property type="entry name" value="IND-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223:SF125">
        <property type="entry name" value="OS08G0506700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16223">
        <property type="entry name" value="TRANSCRIPTION FACTOR BHLH83-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="264"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB36084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="MBA0587847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="375" mass="41631" checksum="AB3729059C550641" modified="2015-04-29" version="1">MDSSTPPSCQNQNSQPNSELLRFLSAPSSLLAPFSESLDTGLSKGGPHSDRLIYRFMNPSQDKSGTEATVDHANSRQTFPGLPPHYPRQTSSAMDTSYFLLGMDPRCGKPGTSSLLRQSSSPPGLFTNLSVQTGLGSYTNGELSPSSSNRLKNQISFSSRLPSSLGILSQISEIGDDAKLGTGYQYGSWNDSANFPENFSGSKTTQDNDPNFFSANQNSDSGSRLHVLSHHLSLPKTSNETPAMEKFLSFQDSVPCKIRAKRGCATHPRSIAERVRRTRISERMRKLQELVPNMDKQTNTADMLDLAVDYINDLQKQFKVTEREPQFPIQHFFLVLCAFFSSYTCNNMIFFSDAKRPSCKLQVLKYLKPIPNQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S0P2</accession>
    <name>A0A0D2S0P2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_006G222000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the cytochrome b5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB37819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S0P2"/>
    <dbReference type="STRING" id="29730.A0A0D2S0P2"/>
    <dbReference type="Gramene" id="KJB37819">
        <property type="protein sequence ID" value="KJB37819"/>
        <property type="gene ID" value="B456_006G222000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800369"/>
    <dbReference type="eggNOG" id="KOG0537">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050668">
        <property type="entry name" value="Cytochrome_b5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359">
        <property type="entry name" value="CYTOCHROME B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19359:SF129">
        <property type="entry name" value="CYTOCHROME B5 ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="13">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB37819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="134" mass="15001" checksum="F288C79D209C86B6" modified="2015-04-29" version="1">MVGDGKVFTLAQVSEHKTPKDCWLIINGKVYDVTKFLEDHPGGDEVLLSATGKDATDDFEDVGHSDSARDMMDQYYVGEIDISTIPKKTTYKPPNQPHYNQDKTSEFIIKLLQFLVPLAILCLALGIHHYTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1W6</accession>
    <name>A0A0D2S1W6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_004G183200</name>
        <name evidence="7" type="ORF">Gorai_015064</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2S1W6"/>
    <dbReference type="Gramene" id="KJB25255">
        <property type="protein sequence ID" value="KJB25255"/>
        <property type="gene ID" value="B456_004G183200"/>
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    <dbReference type="eggNOG" id="KOG0017">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 4"/>
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Damaged DNA binding protein"/>
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        <property type="entry name" value="Rad1_Rec1_Rad17"/>
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    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
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    </dbReference>
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        <property type="entry name" value="DNA clamp"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB25255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0584241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="298" mass="33112" checksum="B8F0A4272582C795" modified="2015-04-29" version="1">MSSSAVEAEAPDLVCRLDNVQGMVDALSAVRWKRHQDAVVELSEHGVVLIVEDTGCLQAKVYLQRELFVLYEYHAEGRPRFGVSLGLFVDCLNSFSAPGRSSMIEIQYPGPDMQLLIKSVDSLDACIYAEIRTRIPDTISWDYNFEPAGSTPLTFTVKSAALKEAIDDLEWPGSSIQINLQPDPPCITFKGEGHGDLQIDFTYYVNTDLVIAFHCDCQVSYRYKYKFLRATTSNLPSSVIKDNRGSKLTIGRGGMLKVQHLVSVARSATSHPHIGSAGHQQPSRIAYIEFFVKSEVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S2D2</accession>
    <name>A0A0D2S2D2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G131400</name>
        <name evidence="7" type="ORF">Gorai_004722</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2S2D2"/>
    <dbReference type="STRING" id="29730.A0A0D2S2D2"/>
    <dbReference type="Gramene" id="KJB77317">
        <property type="protein sequence ID" value="KJB77317"/>
        <property type="gene ID" value="B456_012G131400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780190"/>
    <dbReference type="eggNOG" id="ENOG502QRMA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFQAQQF"/>
    <dbReference type="OrthoDB" id="411524at2759"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000137">
        <property type="term" value="C:Golgi cis cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052546">
        <property type="term" value="P:cell wall pectin metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010442">
        <property type="term" value="P:guard cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048358">
        <property type="term" value="P:mucilage pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd06429">
        <property type="entry name" value="GT8_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF74">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25557">
        <property type="entry name" value="GAUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB77317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0601548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="533" mass="61659" checksum="6CF4A11B19657216" modified="2015-04-29" version="1">MRRRGLDFRRPVRKRFPNVVWWTVCGILVLVLIVVLSREGQIESKPTISRKPYRRDRIMEGVTVTDEMLSSNSVTRQLTDQISLAKAFVVIAKESNNLQFAWELSAQIRNSQALLSNAATRRTPLTVGESETAIRDMALLLYQAQQLHYDSATMLMRLRAKIQTLEEQMSSANEKSSKYGQIAAEEVPKSLYCLGVRLTTEWFGNPNLQKKHRERKQMDAKLKDNSMYHFCIFSDNILASSVVVNSTALNSKNPDKIVFHLVTDEINYAAMKAWFTVNSFRGVTVEVQKFEDFKWLNASYVPVLKQLQDSETQSYYFSGHNDDGRTPIKFRNPKYLSMLNHLRFYIPEVYPALKKVVFLDDDIVVQKDLSGLFSIDLNGNVNGAVETCMETFHRYHKYLNYSHPLIRAHFDPDACGWAFGMNVFDLVEWRKRNVTGIYHYWQERNVDRTLWKLGTLPPGLLTFYGLTEALDPSWHVLGLGYTNVDPQLIEKGAVLHFNGNSKPWLKIGIEKYKPLWEKYVDYSHPLLQQCNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3I3</accession>
    <name>A0A0D2S3I3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G151500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3I3"/>
    <dbReference type="Gramene" id="KJB77692">
        <property type="protein sequence ID" value="KJB77692"/>
        <property type="gene ID" value="B456_012G151500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779956"/>
    <dbReference type="eggNOG" id="KOG1277">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DAPCRVN"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF140">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007354289" description="Transmembrane 9 superfamily member" evidence="10">
        <location>
            <begin position="28"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="554"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB77692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="592" mass="67582" checksum="18355A40984DED85" modified="2015-04-29" version="1">MSSSVFSAVRSFSLFAFLFLFLSPALASESDHKYQSDDPVTLWVNKVGPYNNPQETYNYYSLPFCHPGTNPSHKWGGLGEVLGGNELIDSQIDIKFQKNVDKSTICQLELDEAKVRQFKDAIENSYWFEFFMDDLPLWGFVGELHPDKNSDNGKHVLYTHKNIVIKYNKDQIIHVNLTQESPKPLEAGRVLDLTYSVKWLQTNVTFARRFDVYLDYPFFEHQIHWFSVFNSFMMVIFLTGLVSMILMRTLRNDYAKYAREDDDLESLERDVSEESGWKLVHGDVFRPPRYLALLSAVVGTGAQLAMLVLLVILLAIVGTLYVGRGAIVTTFILCYAFTSFISGYVSGGMYSRNGGKNWIKAMILTASLFPFMCFGIGFILNTIAIFYGSLAAIPFGTMVVVFVIWAFISFPLALLGTVVGRNWSGAPNNPCRVKTIPRPIPEKKWYLTPSVVSMMGGLLPFGSIFIEMYFVFTSFWNYKVYYVYGFMLLVFLILIIVTICVTIVGTYFLLNAENYHWQWTSFFSAASTAIYVYLYSVYYYHVKTKMSGFFQTSFYFGYTLMFCLGLGILCGAVGYLGSNLFVRRIYRNIKCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S3R3</accession>
    <name>A0A0D2S3R3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hexosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_009G185300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1 5">Glycan metabolism; pectin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyltransferase 8 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S3R3"/>
    <dbReference type="STRING" id="29730.A0A0D2S3R3"/>
    <dbReference type="Gramene" id="KJB57893">
        <property type="protein sequence ID" value="KJB57893"/>
        <property type="gene ID" value="B456_009G185300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQZJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMDDISH"/>
    <dbReference type="UniPathway" id="UPA00845"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047262">
        <property type="term" value="F:polygalacturonate 4-alpha-galacturonosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045489">
        <property type="term" value="P:pectin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029993">
        <property type="entry name" value="GAUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32116:SF7">
        <property type="entry name" value="GALACTURONOSYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25557">
        <property type="entry name" value="GAUT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB57893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="526" mass="60600" checksum="D8FB55C6355339E7" modified="2015-04-29" version="1">MKMKVKVRYIVLNLLWVSVFSPIFIYTYVVGTFFDPSFSRLDFLDDVAAFTLSGDTSHLHVVPLETSTALKKPVGVVYSDHSANSFPNEMTEHKSTRVLSAASEERQPLLNNPITRAYESQLLAIRLEEQHTLPPGKIEQKEHSVNKSDQMTEAADAQVRRLKDLLIRAKVYISLPAIKSNSRLTRELRLRIKELSRAIGDAAKDTDLPKSAFEKLKAMEQSLEKGKQIQDNCGASIKRLRAMLHSTEDQLRVHKKKTTFLAQLTAKTLPKGLHCLPLRLTTEYYTLNSSQQNFLDEDKLEDPRLYHYALFSDNILAAAVVVNSTISHVKHPSKHVFHIVTDRLNYAAMRMWFLCNSPGKVTIQVQNIEEFTWLNSSYSPVLKQLGSPSIRDYYFRARRSNSVSNLKYRNPKYLSILNHLRFYLPEIFPKLNKVLFLDDDVVVQKDLSDLWSLDLKGNVNGAVETCGESFHRFDRYFNFSHPLISKNFDPHACGWAYGMNIFDLVEWRRQNITEVYHRWQKLVSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S647</accession>
    <name>A0A0D2S647_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Squalene monooxygenase</fullName>
            <ecNumber evidence="5 13">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G222400</name>
        <name evidence="16" type="ORF">Gorai_012462</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Membrane</location>
            <topology evidence="2 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="5 13"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0595596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S647"/>
    <dbReference type="STRING" id="29730.A0A0D2S647"/>
    <dbReference type="Gramene" id="KJB58702">
        <property type="protein sequence ID" value="KJB58702"/>
        <property type="gene ID" value="B456_009G222400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58703">
        <property type="protein sequence ID" value="KJB58703"/>
        <property type="gene ID" value="B456_009G222400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58706">
        <property type="protein sequence ID" value="KJB58706"/>
        <property type="gene ID" value="B456_009G222400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1298">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EHDAYAG"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009725">
        <property type="term" value="P:response to hormone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000074">
        <property type="entry name" value="Squalene monooxygenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0274">FAD</keyword>
    <keyword evidence="6 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="14">
        <location>
            <begin position="209"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB58703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0595596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="453" mass="49519" checksum="065451D183B68C17" modified="2015-04-29" version="1">MADWYLWAWILCSTMTLVVLRGSVLKRRKGNGISATRGESVRRVLAGNGECRSADGSDADVIVVGAGVAGSALAHTLGKDGRRVHVIERDLTEPDRIVGELLQPGGYLKLIELGLEDCVEEIEAQKVFGYALFKDGKHTRLSYPLENFHSDVSGRSFHNGRFIQRMREKAASLPNVRLEQGTVTSLLEEKGTIRGVQYKTKDGRELTAFAPLTIVCDGCFSNLRRSLCNPKVDVPSCFVGLVLENCHLPYSNHGHVILADPSPILFYPISSTEVRCLVDIPGQKVPSIANGEMTNYLKTIVAHQVPPEIYDSFVAAVDKGNIRTMPNRSMPASPYPTPGALLMGDAFNMRHPLTGGGMTVALSDIVVLRDLLRPLRDLNDGPNLCKYLESFYTLRKPVASTINTLAGALYKVFSASPDQARKEMRQACFDYLSLGGVFSTGPISLLSGLNPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SBE3</accession>
    <name>A0A0D2SBE3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G054200</name>
        <name evidence="4" type="ORF">Gorai_016118</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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            <dbReference type="PubMed" id="30476109"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">8</strain>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="4">8</strain>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
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        <name evidence="1" type="ORF">B456_007G181700</name>
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            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SFP6"/>
    <dbReference type="Gramene" id="KJB43059">
        <property type="protein sequence ID" value="KJB43059"/>
        <property type="gene ID" value="B456_007G181700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="101" mass="11819" checksum="6F4779B91AFB5B78" modified="2015-04-29" version="1">MNIQGPFNYMEKPGKKIEHNPVRHISVSNTLHPSSSDIKARMLQKNNESEQNRLIEGYKSSYQNNISHLLKKRLILFSLYMLIPMYQKLYCKSTEIVDSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGM4</accession>
    <name>A0A0D2SGM4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">apyrase</fullName>
            <ecNumber evidence="2">3.6.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">ATP-diphosphohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Adenosine diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NTPDase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">B456_013G191600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside 5'-phosphate + 2 phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:36795"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SGM4"/>
    <dbReference type="STRING" id="29730.A0A0D2SGM4"/>
    <dbReference type="Gramene" id="KJB82352">
        <property type="protein sequence ID" value="KJB82352"/>
        <property type="gene ID" value="B456_013G191600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1385">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GFEACYA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004050">
        <property type="term" value="F:apyrase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017110">
        <property type="term" value="F:nucleoside diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24041">
        <property type="entry name" value="ASKHA_NBD_AtAPY1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.150:FF:000008">
        <property type="entry name" value="Apyrase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="276"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="KJB82352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="523" mass="56735" checksum="8A731A1D09403682" modified="2015-04-29" version="1" fragment="single">VKFIINSKIPKFRNLEDLEPLPASTGNGQIRYRTPSSAELLESGPNGGSLSPTGNGTDDHLEKMIKRSMARHDSISDKIHKYRGVLLVISIPIVLITFFLYVMPGKSASDAAVLEEIELNSRRVGANSRGNRNYAVIFDAGSSGSRVHVYCFDQNLDLLKPGLSYYAKDPQAAANSLTSLLDKAESVVPLDLRSKTPVRVGATAGLRALGGEASDKILQSVRELLKSRSTLKSEANGVKILDGSQEGSYEWVTINYLLGNLGRTYQDTVGIVDLGGGSVQMAYAISENAASRAPSVPAGQDNYVNEMYLKGSKYYLYVHSYLHYGLLAARAEIFKATEDSGNPCILEGFDGTYKYGGEEYKASAPSSGSSMEECRRVTLKALKVNDSCTHMKCTFGGIWNGGGGDGQKNLFVASFFFDRAAEAGFIKASDPVAKVQPHSFADAAKRACQTKYADAKAIYKDLGESNLAYICMDLVYQYTLLVDGFGLDPYQDVSLVKKVKYRNSFVEAAWPLGSAIEAVSAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SGV5</accession>
    <name>A0A0D2SGV5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_007G090700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. PCMP-H subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB41106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SGV5"/>
    <dbReference type="STRING" id="29730.A0A0D2SGV5"/>
    <dbReference type="Gramene" id="KJB41106">
        <property type="protein sequence ID" value="KJB41106"/>
        <property type="gene ID" value="B456_007G090700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802591"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IQHAMRV"/>
    <dbReference type="OrthoDB" id="772730at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000690">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF456">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN ELI1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="187"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="252"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="314"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB41106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="637" mass="71663" checksum="42C8ECDA7E138C96" modified="2015-04-29" version="1">MLTCANLNQPWNSTLPTLALLQKCRTLTDVNQIHGRLITTGFIRSQVLTTKIVLTFSPSPFTPLVDFARYVFFTYLAFRSPKQDEDPFLWNAVIKSYSHGREAQEAFIILCLMLENGVPFDKFSLSLVLKACSQLGLLKEGMQVHGLLRKLNFGSDLFLQNCLISYYLRCGFIGYARQLFDRMSMRDSVSYNSMIDGYIKRGMIDLAKELFDVMPLEKKNLITWNSMISGYTQLKDGMGLALGLFEKMPDRDLISWNSMINGYVKCGNMEDAQILFDKMPRWDVVSWANMINGYAKVGKIDLARSLFNEMSERDIVVCNAMMAGCVQNGYCGEALEIFYHLQRNCSLQPDSATLLIALSAIAQLGHVDKGLALHHYLKQKKFSLGGRLGVALIDMYSKCGSIKDAVLVFEGIKYKTVDHWNAMIGGLAIHGMGELAFKLLMDMEKLCVEPDDITYIGVMNACGHAGLVKEGLVCFDIMRRVHKMVPKLQHYGCMVDILGRAGQIDVARKFIEEMPIEANDVIWRSLLSACKNHENIDVGEPAAKHLITLDSCNSSSYVLLSNMYAGLGMWNAVSSVRLMMKERNLKKIPGCSWIELEGTVHEFFVQDKSHPQVMEIYSLLDSLSTSNSEVTPYVHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHN8</accession>
    <name>A0A0D2SHN8_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_009G427800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHN8"/>
    <dbReference type="STRING" id="29730.A0A0D2SHN8"/>
    <dbReference type="Gramene" id="KJB62653">
        <property type="protein sequence ID" value="KJB62653"/>
        <property type="gene ID" value="B456_009G427800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768270"/>
    <dbReference type="OMA" id="SENNVCH"/>
    <dbReference type="OrthoDB" id="1910309at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005202">
        <property type="entry name" value="TF_GRAS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31636">
        <property type="entry name" value="OSJNBA0084A10.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50985">
        <property type="entry name" value="GRAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Leucine repeat I (LRI)" evidence="3">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="VHIID" evidence="3">
        <location>
            <begin position="281"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Leucine repeat II (LRII)" evidence="3">
        <location>
            <begin position="362"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="SAW" evidence="3">
        <location>
            <begin position="500"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="VHIID" evidence="3">
        <location>
            <begin position="312"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB62653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="577" mass="64155" checksum="CA79F0ADAC92465D" modified="2015-04-29" version="1">MDSRLCRYGVISAGLSYSTSSSAVPLVPNSLFSSLKSNIGNSPISCFSTQPDCDTNTALSDSQERYNSTENLSGYASCNSSLESSTYFHQLSPSVDCRRESLLVHSDGTSYIEDANSSHEIVYTSQELGTALMAPDGANEVTNTPQTNGQQYRASSKDCQGSSMCQPQTTFVTNCRQSTEAARVEKRLTAIEDLSLQRIPPGNLKQLWIACAKTLSENNIDKFNMLIAKARVAVSIYGEPIQRLGAYMMEGLVARKEASGSNIYRSLHCQEPEGKDLLTYMHTLYEICPYLKFGYMAANGAIAEACRTEDRIHIIDFQIAQGTQWVTLLQALAARPGGAPYVRITGIDDPVSKYARGGGLEAVERRLMALSEQFGIPVEFHGMPVFAADITRDMLDVKPGEALAVNFPLQLHHTPDESVDVNNPRDGILRMVRSLSPKVITLVEQESNTNTAPFLPRFIENLEYYLAMFESIDETMPRHRRERINVEQHCLARDIVNVIACEGKERVERHELFGKWKSRLTMAGFRPYPLSSYVNSVMRGLLKCYSKHYTLVEKDGAMLLGWKDRNLISASAWCCDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SHX7</accession>
    <name>A0A0D2SHX7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA synthetases class I catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G4334001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SHX7"/>
    <dbReference type="STRING" id="29730.A0A0D2SHX7"/>
    <dbReference type="Gramene" id="KJB62743">
        <property type="protein sequence ID" value="KJB62743"/>
        <property type="gene ID" value="B456_009G4334001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="63" mass="7506" checksum="DEECD8DE59935D6E" modified="2015-04-29" version="1" fragment="single">MKHYRLAPKSSIELPHLVSRQITQRYHPLALRYFLINAHYRSPLKYSVIQLEGASNAIFYIYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJB2</accession>
    <name>A0A0D2SJB2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Classical arabinogalactan protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Rainville L.N."/>
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                <person name="Reddy U.K."/>
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                <person name="Mayer K.F."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
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                <person name="Llewellyn D."/>
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                <person name="Udall J."/>
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                <person name="Duke M.V."/>
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                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Zhang T."/>
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                <person name="Mayer K.F."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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        <scope>NUCLEOTIDE SEQUENCE</scope>
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    </reference>
    <comment type="pathway">
        <text evidence="7">Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.17.4" evidence="8"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SLL3"/>
    <dbReference type="SMR" id="A0A0D2SLL3"/>
    <dbReference type="STRING" id="29730.A0A0D2SLL3"/>
    <dbReference type="Gramene" id="KJB42846">
        <property type="protein sequence ID" value="KJB42846"/>
        <property type="gene ID" value="B456_007G170100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105803453"/>
    <dbReference type="eggNOG" id="KOG0143">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PMSHSIV"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009815">
        <property type="term" value="F:1-aminocyclopropane-1-carboxylate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071398">
        <property type="term" value="P:cellular response to fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009693">
        <property type="term" value="P:ethylene biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000002">
        <property type="entry name" value="1-aminocyclopropane-1-carboxylate oxidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050295">
        <property type="entry name" value="Plant_2OG-oxidoreductases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47991">
        <property type="entry name" value="OXOGLUTARATE/IRON-DEPENDENT DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0266">Ethylene biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="153"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0590204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="310" mass="35235" checksum="58652D1AE3048FBF" modified="2015-04-29" version="1">MATFPVINLEKLNGAERSTTMDKINDACENWGFFQVLNHGIPHDFLDTVERLTKEHYKKCMEQRFKELVASKALEGLQAEVTDMDWESTFYIRHLPQSNVAEIPDLTDEYRNVMKEFAVKLENLAEELLDLFCENLGLEKGYLKMAFNGSKGPTFGTKVSNYPPCPTPDKIKGLRAHTDAGGIILLFQDPIVGGLQILKNGEWVDVPPMRHSFVINLGDQLEVISNGRYRSVEHRVMTQTQGSRMSIASFYNPGSDAIIYPAPALVENEAEEKKEWYPKFVFEDYMKLYAGMKFQAKEPRFEAMKATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SMW7</accession>
    <name>A0A0D2SMW7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_007G309200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SMW7"/>
    <dbReference type="STRING" id="29730.A0A0D2SMW7"/>
    <dbReference type="Gramene" id="KJB45503">
        <property type="protein sequence ID" value="KJB45503"/>
        <property type="gene ID" value="B456_007G309200"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB45504">
        <property type="protein sequence ID" value="KJB45504"/>
        <property type="gene ID" value="B456_007G309200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105761149"/>
    <dbReference type="eggNOG" id="ENOG502QR4U">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KICASWE"/>
    <dbReference type="OrthoDB" id="125347at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018289">
        <property type="entry name" value="MULE_transposase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004332">
        <property type="entry name" value="Transposase_MuDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006564">
        <property type="entry name" value="Znf_PMZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973:SF117">
        <property type="entry name" value="F10A16.15 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31973">
        <property type="entry name" value="POLYPROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03108">
        <property type="entry name" value="DBD_Tnp_Mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10551">
        <property type="entry name" value="MULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00575">
        <property type="entry name" value="ZnF_PMZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="6">
        <location>
            <begin position="637"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="724"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB45504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="769" mass="86953" checksum="74A0AF6026F0A1AE" modified="2015-04-29" version="1">MATKRVIAVCQSGGEFETDKSGVMLYKGGDAHAIDLDDQTKFDDFKKELAEMFNLNMSTMSVKYFLPGNKKTLISISNDKDLKRLIKFHGNSTTVDVFILMEENVPHDVSNMPASRSSRTTLSEAVAPAPDPAPAPAPVLASLDPPLDVMDDTTRSNIPLAASLDIVDATNHIDPHIDLAPEFSSILPLAKTTQQWQNTITGVGQRFTGVQEFRETLRKYAIAHQFAFRYKKNDSHRVTVKCRAEGCPWRIHASRLSTTQLICIKKMNPTHTCEGAALTTGHQATRSWVASIIKERLKVFPTYKPKDIVQDIKQEFGIQLNYFQAWRGKEIAREQLQGSYKDAYSQLPLFCERIMETNPGSLATFSTKEDSSFHRLFIAFHASLSGFLQGCRPLLFLDSIPLNSKYQGTLLAATAADGNDDVFPVAFSVVDAETDENWYWFLLQLKSALSTSCPITFVADIQKGLRESISEIFKGSFHGYCLRYLTEQLIRDLKGQFSHEMKRLMIDDLYNAALAPRPEAFHSYINSIKKISLEAYNWIIQSEPQYWANSYFQGARYNHMASNFGELFYSWVSDAHELPITQMVDVIRQKVMELIYSRRAESDHWLTRLTPCMEEKLEKESLKVRTLQVLLTSGSIFEVRGDSTTEMVDMDRWDCSCKGWQLTALPCSHAIAVISCIGRSPYDFCSRYFTTESYRLTYAESIQPIPDVERHLQKDTSSALVTVTPPPTRRPPGRPTTKKVGTPEVMKRQLQCSRCKGLGHNKSTCKELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2STL3</accession>
    <name>A0A0D2STL3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">4-hydroxy-4-methyl-2-oxoglutarate aldolase</fullName>
            <shortName evidence="9">HMG aldolase</shortName>
            <ecNumber evidence="9">4.1.1.112</ecNumber>
            <ecNumber evidence="9">4.1.3.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Oxaloacetate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_006G075500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6 9">Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate</text>
            <dbReference type="Rhea" id="RHEA:22748"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:58276"/>
            <dbReference type="EC" id="4.1.3.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>oxaloacetate + H(+) = pyruvate + CO2</text>
            <dbReference type="Rhea" id="RHEA:15641"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.112"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class II aldolase/RraA-like family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.112" evidence="9"/>
    <dbReference type="EC" id="4.1.3.17" evidence="9"/>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2STL3"/>
    <dbReference type="STRING" id="29730.A0A0D2STL3"/>
    <dbReference type="Gramene" id="KJB34620">
        <property type="protein sequence ID" value="KJB34620"/>
        <property type="gene ID" value="B456_006G075500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105798846"/>
    <dbReference type="eggNOG" id="ENOG502QV2N">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008428">
        <property type="term" value="F:ribonuclease inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051252">
        <property type="term" value="P:regulation of RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010203">
        <property type="entry name" value="RraA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01935">
        <property type="entry name" value="NOT-MenG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006875">
        <property type="entry name" value="PRK09372.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB34620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="225" mass="24101" checksum="ABB936DAD3F353E0" modified="2015-04-29" version="1">MQVLSNSVKLAWVVGTRMILLNSNNQLLSSLTQFSSSPLSSLQFQLRTKSSSDFPAGRHRAAVATADVCDSNAALLVNGDLRALDPIFKIYGRRLAFSGPIVTVKVFEDNVLVRQLLETEGNGRVLVIDGGGSTRCALVGGNLAQWAHDMAWAGIIMNGCIRDVDEINACDIGVRALGSNPLKSNKKAVGDKHVPVQIAGTLIHDGEWLYADSDGILISKTELSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SYL0</accession>
    <name>A0A0D2SYL0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Magnesium-dependent phosphatase-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_008G017400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SYL0"/>
    <dbReference type="STRING" id="29730.A0A0D2SYL0"/>
    <dbReference type="Gramene" id="KJB47241">
        <property type="protein sequence ID" value="KJB47241"/>
        <property type="gene ID" value="B456_008G017400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762743"/>
    <dbReference type="eggNOG" id="KOG4549">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TQFTENQ"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000120">
        <property type="entry name" value="Magnesium-dependent phosphatase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB47241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="20083" checksum="F7F10945605CC169" modified="2015-04-29" version="1">MGEERVKEEALQLIGMFQLLPRLVVFDLDYTLWPFYCLRRSKRETPSLYPHAKGILYALKDKRINLAIASRSPTADTANTFLDKLSIKSMFVTKEIFFSCKNKTDHFRRIQSRTGIPFNSMLFFDDEDWNIEAASKMGVTSIYVDNGVNLRALRRGLTQFTENQNASDKNQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZS2</accession>
    <name>A0A0D2SZS2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G035700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB47666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2SZS2"/>
    <dbReference type="STRING" id="29730.A0A0D2SZS2"/>
    <dbReference type="Gramene" id="KJB47666">
        <property type="protein sequence ID" value="KJB47666"/>
        <property type="gene ID" value="B456_008G035700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105762933"/>
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        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MYB transcription factor MYB48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Homeodomain-like"/>
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        <property type="entry name" value="Homeodomain-like_sf"/>
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        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
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        <property type="entry name" value="F14D16.11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47994:SF5">
        <property type="entry name" value="F14D16.11-RELATED"/>
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    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="MYB_LIKE"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="9"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="62"/>
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        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="62"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB47666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="257" mass="29072" checksum="A34F1510A3FC5B1A" modified="2015-04-29" version="1">MGRSPCCEKAHTNKGAWTKEEDDRLIAYIRAHGEGCWRSLPKAAGLLRCGKSCRLRWINYLRPDLKRGNFTEEEDELIIKLHSLLGNKWSLIAGRLPGRTDNEIKNYWNTHIRRKLLNRGIDPATHRPLNEAGVHQDVSSTISFNGVKQEKDKMNNPNGFVETDEKKIPAVEERCPDLNLDLRISPPLYHQTQQHADPFKTGGKTLCLFCSLGVKNSRQCICSIDTAASSSGNNTNTAYDFLGLKTGFLDYRSLEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SZX2</accession>
    <name>A0A0D2SZX2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_006G179600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2SZX2"/>
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        <property type="protein sequence ID" value="KJB36865"/>
        <property type="gene ID" value="B456_006G179600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1609">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
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    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214:SF36">
        <property type="entry name" value="RING-CH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46214">
        <property type="entry name" value="ZINC FINGER, RING-CH-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RING/U-box"/>
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        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="92"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB36865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="235" mass="25690" checksum="FF32D520495F4D82" modified="2015-04-29" version="1">MSSLEMSHIDLEQGTHRRNESEVSAGEASVCFSDADEGSCYSQFYSTTGGSYDEYSFGCEIGGDSDSRRVSSASDCSVEVRAPSGANELKLHLAKVEKDCRICHLGLESNSHESGAPIELGCSCKDDLAAAHKHCAEAWFKIRGNKTCEICHSIARNVVGVNEVESTEQPNETNSSTATTAVLGAASYTESRSFWHGHRFLNFLLACMSSNKIQRRKKKIKEQNYCKGAWGNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5B2</accession>
    <name>A0A0D2T5B2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF4005 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G130200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subunit">
        <text evidence="7">Binds to multiple calmodulin (CaM) in the presence of Ca(2+) and CaM-like proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IQD family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5B2"/>
    <dbReference type="STRING" id="29730.A0A0D2T5B2"/>
    <dbReference type="Gramene" id="KJB49631">
        <property type="protein sequence ID" value="KJB49631"/>
        <property type="gene ID" value="B456_008G130200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763958"/>
    <dbReference type="eggNOG" id="ENOG502R300">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PRCPRDE"/>
    <dbReference type="OrthoDB" id="776767at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.190:FF:000062">
        <property type="entry name" value="IQ-domain 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025064">
        <property type="entry name" value="DUF4005"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295">
        <property type="entry name" value="IQ-DOMAIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32295:SF6">
        <property type="entry name" value="PROTEIN IQ-DOMAIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13178">
        <property type="entry name" value="DUF4005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF4005" evidence="9">
        <location>
            <begin position="352"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="12"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="235"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB49631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="501" mass="56275" checksum="36F65ADD4B037698" modified="2015-04-29" version="1">MGMKGGTSWLTAVKRAFRSPTKDTHEDEKKRDKRRWIFRKQNTSPVKSVGNNGGGGASTAAAEQRHAIAVAVAKAAEAEAAVATAQAALQAARLTKPSYGRKYHFAAIVIQTAFRGYLARRALRALKGLVKLQALVRGHNVRKQAKMTLRCMQALVKVQSRVLDQRMRLSHDSCSRKSAFSDTNSVWESRYLQDISDRRSLSREGSSIADDWDERPHTVEEVKAMLQHRKEAALKREKSLSQALSQQMRRARRSPSMGGQDEWLDRWMPAKPWDNRGRASMDQRDNVKTVEMDTSQPYSYLAPNYRRTNSNHYHQRPSSPLHRAQHNAQPFHPAPITPSPSKTRPVQVRSASPRCVREDRTSFSSSQTPSLRSNYYYTGRVSTQASTSINNATTLPNYMAATESAKARIRSQSAPRQRPSTPERDRIGSARKRLSFPVPEPYGIGMGYRGYGHSLRSPSFKSVSGSQFGLERQSNYSSCCTESLGGEMSPSSTSDLRRWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5D1</accession>
    <name>A0A0D2T5D1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_006G274400</name>
        <name evidence="17" type="ORF">Gorai_001927</name>
    </gene>
    <organism evidence="16 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="17 19" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="17" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="17">8</strain>
            <tissue evidence="17">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the BBP/SF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0588838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5D1"/>
    <dbReference type="STRING" id="29730.A0A0D2T5D1"/>
    <dbReference type="Gramene" id="KJB38830">
        <property type="protein sequence ID" value="KJB38830"/>
        <property type="gene ID" value="B456_006G274400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105800858"/>
    <dbReference type="eggNOG" id="KOG0119">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PGMPSMY"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009737">
        <property type="term" value="P:response to abscisic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.60.10:FF:000011">
        <property type="entry name" value="splicing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000047">
        <property type="entry name" value="splicing factor-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="12" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="481"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="431"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="655"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="701"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="740"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB38830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="MBA0588838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="786" mass="85058" checksum="07FE6EA3B4667580" modified="2015-04-29" version="1">MDSVQTNLNDPQSFSAQTLNSYNQNPPPPPSQTFDSDPVLEHNNANNGALSNPDAHSNTINNTYSFKPDIHKPLLSENGLTNTHSGTTDKDYSGGEEETTSRRRRRSRWDPPSNSNNHQTGNDESASGTKKRKSRWADDEPKPVIQLPDFMKDFTGGIQFDPEIQALNSRLLEISRMLQSGLPLDDRPEGARSPSPEPIYDNLGIRINTREYRARERLTKERQEIISQILKKNPAFKPPADYRPPKLQKKLYIPMKEYPGYNFIGLIIGPRGNTQKRMEKETGAKIVIRGKGSVKEGRLQQKRDLKPDPAENEDLHVLVEAETQESLDAAAAMVEKLLQPVDEVLNEHKRQQLRELAALNGTIRDEEYCRLCGEPGHRQYACPSRTSTFKSDVLCKICGDGGHPTIDCPMKGTTGKKMDDEYQNFLAELGGTVPDSANKQNSSSVSSGSNPPWASSTGGAGSAHPGLGSNAVKPPKEYDDTNLYIGYLPPSLDDDGLISLFSAYGDIVMAKVIKDRVTGLSKGYGFVKYASVDMANNAIKGMNGSLLEGRTIAVRVAGKPPQPAVPPGPPTLSMPTYPVSSQPVGAYPSRQFTTGGPIPNAASASYAGNPVPWGPPVPPPPPYAPYAPPPPPPPGSTIYPPVHGQPMPPYGLQYPPQMQTVPPGVPPPPQPVTSSETAQSFPPGVQSENSTSAPAMPANIYGNSMTAMPPNSQSAYPTSSLGYSSYYNAVPPPPPPPLPTSSTDNSQSLSNVPWAPNPLLTPAASSGEKTTYGADTEYEKFMAEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5D5</accession>
    <name>A0A0D2T5D5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_006G274800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5D5"/>
    <dbReference type="STRING" id="29730.A0A0D2T5D5"/>
    <dbReference type="Gramene" id="KJB38834">
        <property type="protein sequence ID" value="KJB38834"/>
        <property type="gene ID" value="B456_006G274800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38835">
        <property type="protein sequence ID" value="KJB38835"/>
        <property type="gene ID" value="B456_006G274800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38836">
        <property type="protein sequence ID" value="KJB38836"/>
        <property type="gene ID" value="B456_006G274800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB38837">
        <property type="protein sequence ID" value="KJB38837"/>
        <property type="gene ID" value="B456_006G274800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EMGVEHS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930:SF2">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G04250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47930">
        <property type="entry name" value="YALI0C12947P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="449"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB38835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="535" mass="60958" checksum="7AD2C49AFB38DD0F" modified="2015-04-29" version="1">MPVVSEKFPLGIGASPFLCTRFILQTNDNTKKMDCIFSSITTYPFITLRGKLQQSICVTNLAHPNTRICYSKQPKNRRYPRRTKLPPDFGVNLFLEKPRTETDMSTDTEQIKSIYGHNSDSPEEEDDKEDHVNIDLAWESDEVEAISSLFQGRIPQKPGKVGRERPLPLPLPYKLRPLGFPMPKKHVKKSSAGVNSSRASVSQQLYKNPSFLIGLSKEIKDLASDDDVSAVLNKWAPFLRKGSLSITIRELGLMDLPQRALQAFCWAQKMPHLYPDDRILTSTVEVLARKRELKLPVNLEKFTSSTNRSLIEAMLKGFVKGGSLNLAWKLLSVVKQSKRMLDPGIYAKLILELGKNPDKHILVEELLGDLGERDDLNLSQQDCTAIMKVCIRHRKFEIVESLFYWFKQSGRDPSVVMYTTLLHSRYSENKYMEALALVWEMEARECLLDLPAYRVVIKLFIGLKDLARAVRYFSKLKEAGFSPTYDMYRDLINMYMVAGRVGKCKEVCKEASMAGFSLDKRTLLNLSKLEKDILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T5V6</accession>
    <name>A0A0D2T5V6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G101600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T5V6"/>
    <dbReference type="STRING" id="29730.A0A0D2T5V6"/>
    <dbReference type="Gramene" id="KJB71038">
        <property type="protein sequence ID" value="KJB71038"/>
        <property type="gene ID" value="B456_011G101600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049152">
        <property type="entry name" value="EFR3-like_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055296">
        <property type="entry name" value="SRL2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46087:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46087">
        <property type="entry name" value="PUTATIVE, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21052">
        <property type="entry name" value="EFR3_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB71038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="133" mass="15388" checksum="F4461C9B6F0A63F6" modified="2015-04-29" version="1">MDAESNDRKSGKLCEYASRNPLRIPKITSNLEQRCFKDLRNENFGCVKAVLCIYRKLLSSCKEQMPLFASCLLGIIRALLEQTRQDEMRILGCNALVCFMGEHCHISMDFDSLSENLRSLALKRLHYFQTFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T6W1</accession>
    <name>A0A0D2T6W1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Single-stranded DNA binding protein Ssb-like OB fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_008G158800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T6W1"/>
    <dbReference type="SMR" id="A0A0D2T6W1"/>
    <dbReference type="STRING" id="29730.A0A0D2T6W1"/>
    <dbReference type="Gramene" id="KJB50201">
        <property type="protein sequence ID" value="KJB50201"/>
        <property type="gene ID" value="B456_008G158800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50202">
        <property type="protein sequence ID" value="KJB50202"/>
        <property type="gene ID" value="B456_008G158800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB50203">
        <property type="protein sequence ID" value="KJB50203"/>
        <property type="gene ID" value="B456_008G158800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764271"/>
    <dbReference type="eggNOG" id="ENOG502RY17">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LWNEQAD"/>
    <dbReference type="OrthoDB" id="2274046at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd04491">
        <property type="entry name" value="SoSSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000240">
        <property type="entry name" value="Uncharacterized protein At4g28440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048970">
        <property type="entry name" value="OB_Ssb-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472:SF39">
        <property type="entry name" value="F5O8.30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31472">
        <property type="entry name" value="OS05G0244600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21473">
        <property type="entry name" value="OB_Ssb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Single-stranded DNA binding protein Ssb-like OB fold" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB50201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="136" mass="15212" checksum="87E5293ABD9E9D81" modified="2015-04-29" version="1">MAESKSLRKPVFTKVDQLRPGTSGHTLTVKVVSTKMVLQKGRADGPQVRQMRIAECLVGDETGMIIFTARNEQVDLMKEGATVTLRNAKIDMFKGSMRLAVDKWGRVEVDEPASFNVKEDNNLSLIEYELVNVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8S2</accession>
    <name>A0A0D2T8S2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_007G041800</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T8S2"/>
    <dbReference type="STRING" id="29730.A0A0D2T8S2"/>
    <dbReference type="Gramene" id="KJB40005">
        <property type="protein sequence ID" value="KJB40005"/>
        <property type="gene ID" value="B456_007G041800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2535">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TFETRPD"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035265">
        <property type="term" value="P:organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010928">
        <property type="term" value="P:regulation of auxin mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000025">
        <property type="term" value="P:regulation of leaf formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090708">
        <property type="term" value="P:specification of plant organ axis polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Radical SAM core" evidence="19">
        <location>
            <begin position="99"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="18">
        <location>
            <begin position="444"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB40005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="596" mass="67234" checksum="5C99B8570E36AF51" modified="2015-04-29" version="1">MATAVIAPDPKKLPRPGRGGFQAHGLTEEEARVRAIAEIVNSMVELSRKNQTVDLNAIKSAACRKYGLARAPKLVEMIAALPESDRESLLPKLRAKPVRTASGIAVVAVMSKPHRCPHIATTGNICVYCPGGPDSDFEYSTQSYTGYEPTSMRAIRARYNPYVQARSRIDQLKRLGHSVDKVEFILMGGTFMSLPADYRDYFIRNLHDALSGHTSANVEEAVAYSEHSAVKCIGMTIETRPDYCLGPHLRQMLSYGCTRLEIGVQSTYEDVARDTNRGHTVAAVADCFCLAKDAGFKVVAHMMPDLPNVGVERDLESFKEFFESPLFRADGLKIYPTLVIRGTGLYELWKTGRYRNYPPEQLVDIVARILAMVPPWTRVYRVQRDIPMPLVTSGVEKGNLRELALARMDDLGLKCRDVRTREAGIQVRRHNVAPQETVNAEKHINLLKNVMFVFIWIQDIHHKIRPEKVELVRRDYTANEGWETFLSYEDTRQDILVGLLRLRKCGRNTTCPELMGKCSIVRELHVYGTAVPVHGRDADKLQHQGYGTLLMEEAERIASREHRSTKIAVISGVGTRHYYRKLGYELEGPYMVKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T9E5</accession>
    <name>A0A0D2T9E5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_011G173000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2T9E5"/>
    <dbReference type="STRING" id="29730.A0A0D2T9E5"/>
    <dbReference type="Gramene" id="KJB72348">
        <property type="protein sequence ID" value="KJB72348"/>
        <property type="gene ID" value="B456_011G173000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775839"/>
    <dbReference type="eggNOG" id="ENOG502RBAX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYEDGCS"/>
    <dbReference type="OrthoDB" id="670255at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000001">
        <property type="entry name" value="Ethylene-responsive transcription factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044808">
        <property type="entry name" value="ERF_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190">
        <property type="entry name" value="DNA-BINDING DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31190:SF469">
        <property type="entry name" value="ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR 1B-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="69"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB72348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="199" mass="22373" checksum="85886259A9982699" modified="2015-04-29" version="1">MDSFLFESPNSISSSESSFGSPEFSSFNHNSLPFNENDSEEMLLYGLLTEVKTETSSSTEKGSPTKEKCYRGVRRRPWGKFAAEIRDSTRHGTRVWLGTFESAEAAALAYDQAAFAMRGSAAILNFPVERVRESLEEMKCNQEEGCSPVVALKRTHSMRRKMTSRSKKERDARINNAMVIEDLGADYLEQLLTQTASPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TAI1</accession>
    <name>A0A0D2TAI1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_009G1296001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="18" mass="1811" checksum="30949726763631B6" modified="2015-04-29" version="1" fragment="single">LEVVGPGGPPDGHGDDRH</sequence>
</entry>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the SGS3 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="122"/>
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    </feature>
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    </feature>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
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            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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            <tissue evidence="2">Leaf</tissue>
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    <reference evidence="2" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
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                <person name="Thrash A."/>
                <person name="Conover J.L."/>
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                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">8</strain>
            <tissue evidence="2">Leaf</tissue>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TBK1"/>
    <dbReference type="Gramene" id="KJB53989">
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        <property type="gene ID" value="B456_009G015000"/>
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    <dbReference type="eggNOG" id="ENOG502QR76">
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    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
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    <dbReference type="PANTHER" id="PTHR35834">
        <property type="entry name" value="ARMADILLO-TYPE FOLD PROTEIN-RELATED"/>
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    <dbReference type="PANTHER" id="PTHR35834:SF2">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB53989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="MBA0593941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43436" checksum="C27463B58536C9A1" modified="2015-04-29" version="1">MEDSSPKEDDPGVLKLLEALKQASHELQAHPTYKSVQSNSSPIKALLELETESDSIISKDPHLSTLSRHLAELKILVETLERNRGYGLRSFLTRRVSTHSISRVAGSIESEVQALMDRGSIDSLINALKDPWKDEDELARLLSQFEVRVSQGFNPELQDSVLKSKAFSVLQTVLCDPNCSKQIREQAAFCVAALIRFNKDVFVGQVNMGDTIQALLEMKSAHSVKILCELIKFIKSPFVDEILCNGELPKILTLLESKDLSMKVVVFDCILEIGYFGRKEAVEAMLNGGLIEKLVELQRSEFGGDLIGMGKYGNENEESEGQKREKKFLENHPFASCVARFAVQLEVGEGLRKREKRAFKAEILEKVREASVNDAEAATIIAEVLWGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TFT9</accession>
    <name>A0A0D2TFT9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G1796001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB53426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TFT9"/>
    <dbReference type="STRING" id="29730.A0A0D2TFT9"/>
    <dbReference type="Gramene" id="KJB53426">
        <property type="protein sequence ID" value="KJB53426"/>
        <property type="gene ID" value="B456_009G1796001"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027272">
        <property type="entry name" value="Piezo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47049:SF2">
        <property type="entry name" value="PIEZO-TYPE MECHANOSENSITIVE ION CHANNEL HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB53426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="52" mass="5715" checksum="E39CBF10DC1B7F42" modified="2015-04-29" version="1" fragment="single">SHLKVASYLLLPAIQLVVGISHPSWISLPFFIGSCIGIVDWSLTSNFLGLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TH22</accession>
    <name>A0A0D2TH22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Retinoblastoma-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_012G019100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Regulator of biological processes that recruits a histone deacetylase to control gene transcription. May play a role in the entry into mitosis, negatively regulating the cell proliferation. Formation of stable complexes with geminiviridae replication-associated proteins may create a cellular environment which favors viral DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the retinoblastoma protein (RB) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TH22"/>
    <dbReference type="STRING" id="29730.A0A0D2TH22"/>
    <dbReference type="Gramene" id="KJB75013">
        <property type="protein sequence ID" value="KJB75013"/>
        <property type="gene ID" value="B456_012G019100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1010">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000134">
        <property type="term" value="P:negative regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032875">
        <property type="term" value="P:regulation of DNA endoreduplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000030">
        <property type="entry name" value="Retinoblastoma-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000067">
        <property type="entry name" value="Retinoblastoma-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.140:FF:000003">
        <property type="entry name" value="Retinoblastoma-related protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002720">
        <property type="entry name" value="RB_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002719">
        <property type="entry name" value="RB_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028309">
        <property type="entry name" value="RB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024599">
        <property type="entry name" value="RB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742:SF17">
        <property type="entry name" value="RE32990P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13742">
        <property type="entry name" value="RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11934">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01858">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01857">
        <property type="entry name" value="RB_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01367">
        <property type="entry name" value="DUF3452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01368">
        <property type="entry name" value="RB_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Retinoblastoma-associated protein N-terminal" evidence="10">
        <location>
            <begin position="82"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Retinoblastoma-associated protein A-box" evidence="11">
        <location>
            <begin position="413"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="649"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="880"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB75013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1025" mass="112984" checksum="C13E48EC190BAA09" modified="2015-04-29" version="1">MEDTKPSVATSGGTDGDAVEARFNALCKNGLSLDEKACSNAMKLFKETKHLLTSNVSSIGSGTLEEAERFWFSFVLYSLKRLSEKIGENTQQESDESGFSFCQILRATKLNIVDFFKELPQFVVKAGPVLRNMYGEDCATRLEGTEMQANFVHLSLLSKSYKRAFWELFLTSDANIDKQQNATSSSDYVSECHRFGWLLFLALRVHAFSRFKDLVTCANGFVSILAILIIHVPVRFRNFKINDSPHFVKKGDKGVDLLASLCNMYDASEDDLRKKMETANKLIEDILKKKPCPAAECKTETLENIDTDSLIYFEGLMEEKSLSSSLNMLEKDYDNAICNKGDLDERVFVNDEDSLLGLGSFSGGTMNVTGIKRKFDSVASPSKSISSPLSPQRPPASHANGVLGPPSAKMAATPVSAAMTTAKWLRSVICPLPSKPSAELQRFLSSCDKDVTNDVICRAHIILEAIFPRNQECSVTGSLQSVNLMDNIWMEQRILEALKLYYRVLEAMCTAEAQILHAPNLTSLLTNERFHRCMLACSAELVLATHKTATMLFPTVLERTGITAFDLSKVIESFIRHEESLPRELRRHLNSLEERLLESMVWDKGSSMYNSLIVAKPALSAEINRLGLLAEPMPPLDAIATHVNFSGSTPPVPSLQKHETSTGNAGSSILGQNGDVRSPMRPCTELRSVLVERNAFTSPVKDRLLALNNLKKAPLQSAFASPTRPNPGGGGETCAETGISIFFGKINKLAAVRINGMVERLQLSQQIRESVYSLFQKILNQRTSLFFNRHIDQIILCCFYVVAKISQLRLTFKEIICNYRKQPQCKPQVFQSVFVDRSSARRNGRTGQDNVDIIAFYNEIFVPSIKPLLGELGSAGTTTRTSRVAEANNSNDGTCPGSPKVSPFPSLPDMSPKKVSATHNVYVSPLRTSKMDALISHSSRSYYACVGESTRAYQSPSKDLTAINNHLNGYSSPLTGGRKIRGALNFDDVDVGLVSDSMVANSLYLQNGSCASSSGAPLKSEQPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJN5</accession>
    <name>A0A0D2TJN5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G065000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJN5"/>
    <dbReference type="STRING" id="29730.A0A0D2TJN5"/>
    <dbReference type="Gramene" id="KJB75938">
        <property type="protein sequence ID" value="KJB75938"/>
        <property type="gene ID" value="B456_012G065000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB75941">
        <property type="protein sequence ID" value="KJB75941"/>
        <property type="gene ID" value="B456_012G065000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780677"/>
    <dbReference type="eggNOG" id="ENOG502QPVW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF14">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB75938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="45331" checksum="38D7C670C2B9F958" modified="2015-04-29" version="1">MSGGYSNSKKTDDIYEKVCGQQASFAALTMSRLRCMLRGIDIRICIVLLIAIPVFMFGIYLHGQKITYFLRPLWESPPKPFHEIPHYYNENVTMERLCHLHGWKVRESPRRVFDAVLFNNEIDILALRWNELSPYVTQFVLLESNSTFTSLLKPLLFAGNRHQFKFVEPRLTYGMIGGRFKKGENPFVEEAYQRVALDQLLRIAGIEEDDLLTMSDVDEIPSGHTINLLRWCDDIPPVIHLQLRNYLYSFEYHVDNKSWRASVHRYKPGKTRYAHYRQSDIILSDSGWHCSFCFRYVSEFIFKMKAYSHTDRVRFPHYLNPKRIQDVICKGADLFDMLPEEYTFKEIIGKMGPIPHSYSAVHLPAYLLNNAEKYKYLLPGNCRRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TP93</accession>
    <name>A0A0D2TP93_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Light-mediated development protein DET1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G136900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TP93"/>
    <dbReference type="STRING" id="29730.A0A0D2TP93"/>
    <dbReference type="Gramene" id="KJB77438">
        <property type="protein sequence ID" value="KJB77438"/>
        <property type="gene ID" value="B456_012G136900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779517"/>
    <dbReference type="eggNOG" id="KOG2558">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ITPCLTI"/>
    <dbReference type="OrthoDB" id="18339at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09737">
        <property type="entry name" value="Det1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB77438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="61150" checksum="F533735F46DB12B4" modified="2015-04-29" version="1">MFKTNNVASRIFERQIRTPAPGTSVHSARRFYENLVPSFTIYDVECPDHSFFKFTDDGQYFVCFSRNRQDLIVYRPTWLSFSCKGEDCDNNQELPPQAKRFESFFTQLYVKPLASCNELICKDFFLYMESNQYGIFATSTAQIQDARGTDGAILGVPSFEKITIHLFRLEDGFKLDEKVFHNDCVNLTHNMGAFLYDDLLAVVSLRYQTIHILQIRDSGNLVDVRAIGAYCREDDELFINSSSQLAGNRGDLVDNGTNHDQPNSNNSFLSGIKQRLLSFIFREIWSEETDQTQRVQCLKKKFYFHFQDYVDLVILKVQFLDRHHLLIKFGSVDVGASRNTDQLPAFFAVYNMETTEIVAFYQNAADELYLLFERFCDHFHATSINSMYMNFISSHSNNIHALEQLKSMKNKATSVSQFVKKMLSSLPLNCQSMSPSPYFDQSLFRFDEKLISATDRPRQSTDHPIRFISRRQPNILKFKIKTGPEFGGADGRSKKYSHFLFHPAWPLALSFIQPSLFLPPSAVNIHFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TST1</accession>
    <name>A0A0D2TST1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Inositol-pentakisphosphate 2-kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_009G200000</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20313"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.158"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="12">The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPK1 type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.158" evidence="4 12"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TST1"/>
    <dbReference type="STRING" id="29730.A0A0D2TST1"/>
    <dbReference type="Gramene" id="KJB58226">
        <property type="protein sequence ID" value="KJB58226"/>
        <property type="gene ID" value="B456_009G200000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58227">
        <property type="protein sequence ID" value="KJB58227"/>
        <property type="gene ID" value="B456_009G200000"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB58228">
        <property type="protein sequence ID" value="KJB58228"/>
        <property type="gene ID" value="B456_009G200000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769035"/>
    <dbReference type="eggNOG" id="KOG4749">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HRQHCIV"/>
    <dbReference type="OrthoDB" id="272370at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035299">
        <property type="term" value="F:inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.110:FF:000002">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.110">
        <property type="entry name" value="Inositol-pentakisphosphate 2-kinase, N-lobe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009286">
        <property type="entry name" value="Ins_P5_2-kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043001">
        <property type="entry name" value="IP5_2-K_N_lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14456:SF2">
        <property type="entry name" value="INOSITOL-PENTAKISPHOSPHATE 2-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06090">
        <property type="entry name" value="Ins_P5_2-kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB58226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="473" mass="53320" checksum="2983490AF2C4360C" modified="2015-04-29" version="1">MEKVILEEKDAVDWIYRGEGAANLILAYTGSSPAFIGKVLRIQKSQRNGNSGVKEGRALTTHERLLWRENKELTASSNREILEQLYVKHVMIPLLGPKHVDVGIRVLVTKEFLKSVEKNVTCHRPAWRVHSSQVDVNRDSVLILSDHSIFPDGNLKGEPCITVEIKPKCGFLPFSRFITEENAVKRNVVRFRMHQALKLHNQEISEYSEYNPLDLFSGSREGIQKAIEALYATPQNNFRVFLNGSIVFGGLGGGTNSTTVQVGEAFEDILKNVIQADNGQRTTSFLQLVAETIYISGALEQLLEVQKLDTYDIEGAIHAYYNIISQPCMVCRELCKDKLSCRYTSLHSIPLDQSLKIVKDYLIAATAKDCSLMISFRPKEDGRLPSHNTVYLGSTNQAFECKVYFIDLDLKPLKKMEAYYELDKKIVSCYSQMVKTEHETDKAVTINSNGSVRDQRYALEDGLFTEGCTGKCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TXA1</accession>
    <name>A0A0D2TXA1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G0781002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TXA1"/>
    <dbReference type="STRING" id="29730.A0A0D2TXA1"/>
    <dbReference type="Gramene" id="KJB80043">
        <property type="protein sequence ID" value="KJB80043"/>
        <property type="gene ID" value="B456_013G0781002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPXP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FIWGVIS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF6">
        <property type="entry name" value="PEPTIDASE M50B-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB80043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="142" mass="15781" checksum="A9D948F5FDBCC68B" modified="2015-04-29" version="1" fragment="single">LGSSFWGMALILASTNLLTARIAAGCFLLALVVVLFYAKNWTLRGLSIGFIIFLALIWFLQERTTVHILCYAILFIGVMNSLFSVYDIYDYLISRGVNSSDAEKFAEICPCPCNGVGWGFIWGMISFIFLRASVYLGLLILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UAB7</accession>
    <name>A0A0D2UAB7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G266400</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UAB7"/>
    <dbReference type="Gramene" id="KJB52530">
        <property type="protein sequence ID" value="KJB52530"/>
        <property type="gene ID" value="B456_008G266400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765425"/>
    <dbReference type="eggNOG" id="KOG4332">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000478">
        <property type="entry name" value="Molybdate-anion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="390"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB52530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="460" mass="50699" checksum="61FDB6D8810510AC" modified="2015-04-29" version="1">MELFYFMVFGALGAVVAALELSKNSKDRINTSPAFNSFKNNYLVVYSLMMAGDWLQGPYVYYLYSTYGFGKGEIGQLFIAGFGSSMLFGTIVGSLADKQGRRRACVTYCITYILSCITKHSPQYKILMIGRVLGGIATSLLFSAFESWLVAEHNKRGFEQQWLSLTFSKAIFLGNGLVAILSGLFGNLLVDSLSLGPVAPFDAAACFLAIGMAIILSSWTENFGDSSENKDLLTQFRGAAVAIASDEKIAVLGAIQSLFEGSMYTFVFLWTPALSPNDEEIPHGFIFATFMLASMLGSSLASRLMARSSPRVESYMQIVFVISSASLLLPIITNLLVPPSKEKGGSISFAGCLQLLGFCTFEACVGIFWPSIMKMRSQYIPEEARSTIMNFFRIPLNIFVCIVLYNVNAFPITVMFGMCSIFLFVASILQRRLMAISDKPKMENWTAMKERDPEAEPLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDP3</accession>
    <name>A0A0D2UDP3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_010G167600</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UDP3"/>
    <dbReference type="STRING" id="29730.A0A0D2UDP3"/>
    <dbReference type="Gramene" id="KJB66933">
        <property type="protein sequence ID" value="KJB66933"/>
        <property type="gene ID" value="B456_010G167600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB66934">
        <property type="protein sequence ID" value="KJB66934"/>
        <property type="gene ID" value="B456_010G167600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773719"/>
    <dbReference type="eggNOG" id="KOG2608">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SIYEQNC"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="116"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB66934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="463" mass="53205" checksum="D3DABDE977110179" modified="2015-04-29" version="1">MGESEEKKSTKRDKLRWRWVIGASITIVLAIALASRTKPEISPNFGDTNKSCQCSQGKHRHKGTVEDCCCDYETVDHLNGEVLHPILQELVKTPFFRYYKVKLWCDCPFWPEDHMCRLRDCSVCECPESEFPDSFKPFQRTLSSGDLKCREGKPQAAVDRTLDSKAFRGWTETDNPWTYDDETDNSEMTYVNLQLNPERYTGYNGTSARRIWDAVYSGNCPKYPAEELCQEEKTLYKLISGLHSSISVHIASDYLIDEATNLWGHNLEIMYYRVLQYPNRVENLYFTFLFVLRAVTKAAEYLEQAEYDTGNPTEDLKTQSLMKQLLYDPKLQAACPLPFDEAKLWKGRRGPELKQKIQAQFKNISAVMDCVGCEKCRLWGKLQVSGLGTALKILFSVNDEENLIQILQLQRNEVIALMNLLNRLSESVKFVHEMGAAAEMGRMHYSSRLKSLVQRILASIVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ULM8</accession>
    <name>A0A0D2ULM8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OCEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G139700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB56865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ULM8"/>
    <dbReference type="STRING" id="29730.A0A0D2ULM8"/>
    <dbReference type="Gramene" id="KJB56865">
        <property type="protein sequence ID" value="KJB56865"/>
        <property type="gene ID" value="B456_009G139700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769347"/>
    <dbReference type="eggNOG" id="ENOG502QSAQ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KEYRFTW"/>
    <dbReference type="OrthoDB" id="4869960at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035198">
        <property type="term" value="F:miRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010844">
        <property type="entry name" value="Occludin_ELL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38372">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38372:SF2">
        <property type="entry name" value="DENTIN SIALOPHOSPHOPROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07303">
        <property type="entry name" value="Occludin_ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51980">
        <property type="entry name" value="OCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OCEL" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB56865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1213" mass="133203" checksum="F5FA138B19B4E335" modified="2015-04-29" version="1">MYGGSSKLGRGGGGGRGGGGPRNRSFPPPPPQRPSSATQSGRLSLGSAPRNRPGIGGGSGPAPSVEESFSLVSGNNPLAFAMIIRLAPDLVEEIRRLEAQGETARIKFDSIPTHPTGNVIDVGGKEFRFTWSPEFGDLCDIYEERQMGEDGNGLLVESGCAWRKLNVQRVLDESTTNHVKMRSEEFERKLKSRKAIILDHGNPSMKNQIKQMVAAEASPWKSHFKKMELALKKRNDTPQAAAGGPPKSGYRPGLVSAATAKGRRSSSPLPSPLERSDAAVSPSGLGNTTKTHAGSEDVMPSLVKSKESISSSDKEIPSRASSAGREMQERRGNFGPKPTDLQSLLISLLKENPKGMSLKALEKAVGDTIPNSARKIEPILKKIATFHAPGRYFLKPGVELESLKKSSSESGSSPEGNRHEAPAPEENQDQTLAPVSFLAEKTDEVEEQTHLDSKLTVASDPMEQIDIQQLSPDLGGERKASDNSEGQANSASDSGSDSDSDSDSSDSGSDSGSHSRSRSRSASPAASGSGSSSDSETDASSNSKEGSDEDVDIMTSDDDKETKQDMLTSEPGLLTSPIPWQAEHDMSLHNGMDGNQDDDGSYAVDIEGPGSDAVDIEKDLPEDEQEIGMAANSNKEGEKHEEGTKPSSSDLDEFQERQNFIGNLFDDTENIVKNSVRNEQSNYPEKSGKAKSKRGSDLTHIDEKSERSKRLKSESMSQPPVSGSRDAELFASSRSVDESYQSSNKGDREHADSQKGYILVFPQKSSTDFHQSGRRSSDQGARGKAVNTAERPLKHTESSGHGSKFAEKNVHEGYIIQKENPTRDAQNEDGVMKEKKLSTNTKNIGGKNAVPSDFHHRKHGETFGKPKDSGQNSGTYINSSPKDNSKVNEDRYPANGKSNVLQRELSHLELGEIREPLIDETPVKKQFEKKGSFKQSGSRLSRGKPAGKTNWDSGKPPSPNLSGLKRTPEHHVEDSSRSHHKVVQSQQQQLSRFDRPEVGSQFNRLADNSKTKQTEIGAKLGVVLEDFGESHKKAPTSAPQQQESKRGSVSQFIKESKIPTSNKMADMTDSRKDAVLKEGNVNGRKKRGSSSDEDCLPYFKYEKDEPERRGPIKDSSQYEEYVNEFREKYESYEDLDKTLQTYRNEFEKLGKDLEYSKDRDKEKYYKTLDQLKESYHQCGMRHKRLKKIFIVLHQELKNLKQRLIEFAESHSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UQN2</accession>
    <name>A0A0D2UQN2_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G095800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB70924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UQN2"/>
    <dbReference type="STRING" id="29730.A0A0D2UQN2"/>
    <dbReference type="Gramene" id="KJB70924">
        <property type="protein sequence ID" value="KJB70924"/>
        <property type="gene ID" value="B456_011G095800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105778454"/>
    <dbReference type="eggNOG" id="ENOG502RZTU">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WSTKRWR"/>
    <dbReference type="OrthoDB" id="1111059at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012442">
        <property type="entry name" value="DUF1645_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095:SF101">
        <property type="entry name" value="DUF1645 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33095">
        <property type="entry name" value="OS07G0619500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07816">
        <property type="entry name" value="DUF1645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB70924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="262" mass="29152" checksum="B170CC0E80414DF5" modified="2015-04-29" version="1">MQNDSSDLSFSPSFNSYYSDKKLGDIAATVCRESTGVSDDEEFEFSIELGETPQTSLFPVFNRDLLSSGEEEGKDDEVKEAVRIPLRNLFISDGDLPSSSSSSEVDELEALPTETYCVWKPKQSPASSPNRCTKSKSTGSSSTKRWRLIKDLLKRSNSDGKVSASSSLFLNFDHKSTIEKKHEEKANEKTATAAETVKKKSDGEVTATKMKRVEKASAHEIFYVRNKALKEGDKRRSYLPYRKDLVGIFANVHGLGRNLPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UR71</accession>
    <name>A0A0D2UR71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G106900</name>
        <name evidence="5" type="ORF">Gorai_005738</name>
    </gene>
    <organism evidence="4 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">8</strain>
            <tissue evidence="5">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB71124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0599523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UR71"/>
    <dbReference type="STRING" id="29730.A0A0D2UR71"/>
    <dbReference type="Gramene" id="KJB71124">
        <property type="protein sequence ID" value="KJB71124"/>
        <property type="gene ID" value="B456_011G106900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775854"/>
    <dbReference type="eggNOG" id="ENOG502RYRJ">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GGENMET"/>
    <dbReference type="OrthoDB" id="1933825at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053266">
        <property type="entry name" value="Zinc_finger_protein_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47593:SF9">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47593">
        <property type="entry name" value="ZINC FINGER PROTEIN 4-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB71124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="MBA0599523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="233" mass="25868" checksum="AC5D93B9D9BEA16F" modified="2015-04-29" version="1">MSATSFANSYITTSLYQKLLVHKPFLIIENLWPMTFPRDEEINDADVEIPTLYLYQSGGENMETGGADDNLGVLLSLGLNRREAATSGECDKESKPANASNKVFSCNFCMRKFYSSQALGGHQNAHKRERGAGKRSQPHKTGFPVNPMGFRSLRVLQPHSVVHKDVRSEGSSMVARFSTDSSRPWFGVAGGTPFLGEKPMASIWPGSFRLENLQNQKPQLDADSQKLDLNLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXE7</accession>
    <name>A0A0D2UXE7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GATA transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_011G238800</name>
        <name evidence="16" type="ORF">Gorai_006584</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Transcriptional activator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the type IV zinc-finger family. Class A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0600397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXE7"/>
    <dbReference type="STRING" id="29730.A0A0D2UXE7"/>
    <dbReference type="Gramene" id="KJB73559">
        <property type="protein sequence ID" value="KJB73559"/>
        <property type="gene ID" value="B456_011G238800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73560">
        <property type="protein sequence ID" value="KJB73560"/>
        <property type="gene ID" value="B456_011G238800"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB73561">
        <property type="protein sequence ID" value="KJB73561"/>
        <property type="gene ID" value="B456_011G238800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105776947"/>
    <dbReference type="eggNOG" id="KOG1601">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GPAPDCN"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.50.10:FF:000018">
        <property type="entry name" value="GATA transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051140">
        <property type="entry name" value="GATA_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016679">
        <property type="entry name" value="TF_GATA_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45658:SF51">
        <property type="entry name" value="GATA TRANSCRIPTION FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016992">
        <property type="entry name" value="TF_GATA_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0010">Activator</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="14">
        <location>
            <begin position="246"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="104"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="117"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB73559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0600397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="337" mass="36797" checksum="8A93DD30DD4E863F" modified="2015-04-29" version="1">MIGPTNFIDEIDCGSFFDHIDDLLDFPNEDVEAGFSAPDSAVNAAAFPSIWTAHPESFPGSDSVFSNNSASDLSAELSVPYEDIVQLEWLSNFVEDSNCGASLTIKKQEPNSNNKDSPSHHDHDHHQFQTSSPVSVLESSSSYSGEKPVAAPGKCGRARSKRPRPATFNPRPAIQLISPSSSVNDNDVPQSLFVPKVPSDSENHAESRLLIKLPRQVNPEHKKKKKIKLTLPAAAAPPTDNNTTQNPSVRKCMHCEITKTPQWRAGPMGPKTLCNACGVRYKSGRLFPEYRPAASPTFIPSVHSNSHKKVLEMRTKCGTADAPEMIPNKSNPALDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V3Q6</accession>
    <name>A0A0D2V3Q6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">B456_012G097800</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V3Q6"/>
    <dbReference type="Gramene" id="KJB76636">
        <property type="protein sequence ID" value="KJB76636"/>
        <property type="gene ID" value="B456_012G097800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105780162"/>
    <dbReference type="eggNOG" id="ENOG502QQXY">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="749055at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048638">
        <property type="term" value="P:regulation of developmental growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000021">
        <property type="entry name" value="Putative LRR receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000015">
        <property type="entry name" value="Somatic embryogenesis receptor kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000016">
        <property type="entry name" value="Somatic embryogenesis receptor-like kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47988">
        <property type="entry name" value="SOMATIC EMBRYOGENESIS RECEPTOR KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="14 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002265871" description="non-specific serine/threonine protein kinase" evidence="22">
        <location>
            <begin position="22"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="294"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="574"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="580"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="KJB76636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="642" mass="70648" checksum="D433644CD9081209" modified="2015-04-29" version="1">MKMSLFLLLFFFLSSATVSFSYEPRNHEVEALISIRRELNDPHGVLNNWDEDSVDPCSWAMITCSSENLVIGLGAPSQSLSGTLSGTIGNLTNLRQVLLQNNNISGKIPPELGTLPKLQTLDLSNNRFSNEIPGSFGQLNSLQYLRLNNNSLSGPFPASLAKIPQLAFLDFSYNNLSGPVPKFPARTFNIVGNPLICGSSSTEVCSGSVNADPLSFSLGSSNAEQKSNKLAIALGISLSFATLILLSFALLWHRNKRKRLTILNISDKQEEGLISLGNLRNFTFRELQFATDNFSSKNILGTGGFGNVYKGKLGDDTLVAVKRLKDLTGSFGESQFRTELEMISLAVHRNLLRLIGYCATSNERLLVYPYMSNGSVASRLRGKPALDWNTRKRIAIGAARGLLYLHEQCDPKIIHRDVKAANVLLDDYCEAIVGDFGLAKLLDHADSHVTTAVRGTVGHIAPEYLSTGQSSEKTDVFGFGILLIELITGMRALEFGKTVSQKGAMLEWVKKIQKEKKEEVLVDRELGNNYDRIEVGEMLQVALLCTQYLPTHRPKMSEVVRMLEGDGLAEKWAASHDHSNSTMNHFPNNFSNKSKAPPTAGSKHDEKSYDDESSNKLGTGMDDDDDDEHSLDSYAMELSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V4W1</accession>
    <name>A0A0D2V4W1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G108400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V4W1"/>
    <dbReference type="Gramene" id="KJB76819">
        <property type="protein sequence ID" value="KJB76819"/>
        <property type="gene ID" value="B456_012G108400"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB76819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="100" mass="11558" checksum="CAC87DD80C66158C" modified="2015-04-29" version="1">MKLKKTHLQTTDRMTVNCNKLKAQRQYLTVTRTDNSQSNNRKVITSERNNSPRLSEYISLRFIQQAKAKKISSLKPSVIITLSLMKLLSWAQPKHESLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V7I7</accession>
    <name>A0A0D2V7I7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">phospholipid:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.158</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_010G086400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a glycerophospholipid + a 1,2-diacyl-sn-glycerol = a monoacylglycerophospholipid + a triacyl-sn-glycerol</text>
            <dbReference type="Rhea" id="RHEA:14057"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:136913"/>
            <dbReference type="EC" id="2.3.1.158"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.158" evidence="9"/>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB65255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V7I7"/>
    <dbReference type="STRING" id="29730.A0A0D2V7I7"/>
    <dbReference type="Gramene" id="KJB65255">
        <property type="protein sequence ID" value="KJB65255"/>
        <property type="gene ID" value="B456_010G086400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105772831"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GSDWCAR"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046027">
        <property type="term" value="F:phospholipid:diacylglycerol acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000160">
        <property type="entry name" value="Phospholipid:diacylglycerol acyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB65255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="672" mass="74563" checksum="AEBEF0235F096A8B" modified="2015-04-29" version="1">MSFLRRRKGTDSSKSQNLRCSIVKEDEKNNLYESPRKESYNSKKWSCWDSCCWFIGFVCSVWWFLLLLYNTMPASIPQYVTEAITGPLTDPPGVKLRKEGLTVNHPVVFVPGIVTGGLELWEGHQCAEGLFRKRLWGGSFGELYKRPLCWAQHMSLDNETGLDPPGIRVRPVSGLVAADYFAAGYFVWAVLIANLAQIGYEEKTMYMAAYDWRLSFQNTEVRDQTLSRIKSNIELMVATNGGKKVVVIPHSMGVLYFLHFMKWVEAPPPTGGGGGSEWCAKHIKAVMNIGGPFLGVPKSVSGLFSVEARDIAIARTFAPGFLDKDVFGLQTFQHLMRMTRTWDSTMSMIPKGGETIWGGLDWSPEGSSFNCGAKTLRNNSINNTDQIPNINLANMKNVNYGRIISFGKDVAEAHSSKIERVDLLQDSMKADMLANLTNCDIWIEYHDIGDHRIKAVADYKVYTAGSILDLLHFVSPKLMARGGAHFSYGIADNLDDPNYQHYKYWSNPLETKLPDAPDMEIYSMYGVGIPTERAYVYKVTTATDCSIPFQIDTSAEGGSEDSCLKGGVFSADGDETVPVLSAGLMAAKGWRGKTRFNPSGIPTYIREYSHAPPANLLEGRGTQSGAHVDIMGNFALIEDVIRVAAGATGKELGGDHVYSDIFKWAERINLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2V7X0</accession>
    <name>A0A0D2V7X0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7054 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_012G181400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB78164.1"/>
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    <dbReference type="STRING" id="29730.A0A0D2V7X0"/>
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        <property type="gene ID" value="B456_012G181400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
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    </dbReference>
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        <property type="entry name" value="At4g22758-like"/>
    </dbReference>
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        <property type="entry name" value="DUF7054"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270">
        <property type="entry name" value="BNAC05G50380D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33270:SF18">
        <property type="entry name" value="OS02G0324700 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF7054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7054" evidence="1">
        <location>
            <begin position="14"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB78164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="78" mass="8752" checksum="74420ABB06551B27" modified="2015-04-29" version="1">MVHNEQKKNQGCKGNKLLISVSVLGSSGPIRFVVNEGELVGTVIDIALKSYAREGRYLFLDRILMSFFFIPLVLDQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VAU0</accession>
    <name>A0A0D2VAU0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Pectate lyase</fullName>
            <ecNumber evidence="4 10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_013G078000</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="10">Binds 1 Ca(2+) ion. Required for its activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="4 10"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2VAU0"/>
    <dbReference type="Gramene" id="KJB80041">
        <property type="protein sequence ID" value="KJB80041"/>
        <property type="gene ID" value="B456_013G078000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784458"/>
    <dbReference type="eggNOG" id="ENOG502QQE2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="SMTRCAD"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00824"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018082">
        <property type="entry name" value="AmbAllergen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007524">
        <property type="entry name" value="Pec_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF208">
        <property type="entry name" value="PECTATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04431">
        <property type="entry name" value="Pec_lyase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00807">
        <property type="entry name" value="AMBALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005113499" description="Pectate lyase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="11">
        <location>
            <begin position="162"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB80041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="437" mass="49257" checksum="FE48E2A0263F69CC" modified="2015-04-29" version="1">MGFAGYSYSWFLLSFFALIPTLRAHIAEYDEYWKARELEAIENLNKAYHPNPEEVVRHYNDHFVNTMLEYNNTRRVLKGKKNGPCEITNPVDSCWRCDPNWVKNRKRLADCAPGFARGTTGGKDGKFYVVTDPNDDIANPKPGTLRHAVTQLRPLWITFKKSMIIKLKQELIVTSDKTIDARGANVHICYGAGITVQFSRNVIIHGLHIHHIKPATGGIIRDAENHIGLRTASDGDAISLFGATNIWLDHLSLYDSSDGLIDVIQGSTAITISNCHFTDHNEVLLFGASDNYVADEKMQITVALNRFGKGLVDRMPRCRLGFFHVVNNDYTHWFMYAIGGSSHPTIISQGNRYIASSIYVTKQVTSRGYLSPEQWNKWNWVSQGDHFINGAYFITSGDPNASKLFGAEKMMPFQPGRLVPKLTRYAGTLHCRIGRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VLN3</accession>
    <name>A0A0D2VLN3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA decay factor PAT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_N0144002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="KB204208">
        <property type="protein sequence ID" value="KJB84264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VLN3"/>
    <dbReference type="Gramene" id="KJB84264">
        <property type="protein sequence ID" value="KJB84264"/>
        <property type="gene ID" value="B456_N0144002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QQ60">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039900">
        <property type="entry name" value="Pat1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551:SF29">
        <property type="entry name" value="PROTEIN PAT1 HOMOLOG 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21551">
        <property type="entry name" value="TOPOISOMERASE II-ASSOCIATED PROTEIN PAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB84264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35315" checksum="ABE9A0BC1516FF55" modified="2015-04-29" version="1" fragment="single">DQRAKSAQKGRQSLRGFDSGALKSDFGWPQFTSKYMSTDEIEGILRMQLVATHSNDPYVDDYYHQACLARKSAGAKLRHHFCPTHLRDLPPRARANTEPHAFLQVDALGRLPFSSIRRPRPLLEVDPPNSSAVTNNDQKASDIPLEEEPMLAARVTIEDGLCLLLDVDDIDRFLQFNQLQDGGAQMRQRRQVLLEGLGALLQLVDPLGKSGNTDELAQKDDLVFLRIVSLPKGRKLLARFLQLLPPGGELMRIVCMSIFRYLRFLFGGLPSDPGEDEITINLARVVSSCVHRMDLRALGVCLASVVCSSEQPASSPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VUL4</accession>
    <name>A0A0D2VUL4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_012G025200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB75115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VUL4"/>
    <dbReference type="STRING" id="29730.A0A0D2VUL4"/>
    <dbReference type="Gramene" id="KJB75115">
        <property type="protein sequence ID" value="KJB75115"/>
        <property type="gene ID" value="B456_012G025200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1616">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1716">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019203">
        <property type="term" value="F:carbohydrate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005983">
        <property type="term" value="P:starch catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14526">
        <property type="entry name" value="DSP_laforin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000992">
        <property type="entry name" value="Phosphoglucan phosphatase DSP4, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045204">
        <property type="entry name" value="DSP_laforin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052832">
        <property type="entry name" value="Starch-Glucan_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46642">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE, SUBGROUP, CATALYTIC DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46642:SF3">
        <property type="entry name" value="PHOSPHOGLUCAN PHOSPHATASE DSP4, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="97"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB75115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="401" mass="45632" checksum="67BDBCC6E1F81719" modified="2015-04-29" version="1">MNCLQNLPRSYALPFQGFKCNPRKLLSCSLNMMLHFQGGMNSSNVPRSMVVKAIPGSTSSEKTSNSDSEGKKSETYSHDMTEAMGAVLTYRHELGMNYNFIRPDLIVGSCLQTPEDVDKLRKIGVKTIFCLQQDPDLEYFGVDIGAIQDYAKKCGDIEHIRAQIRDFDAFDLRMRLPAVVSILHKAVNRNGGVTYIHCTAGLGRAPAVALAYMFWVQGYKLSEAHRELLVSLPLFPCFYFRVNSILGAWICFYHFRSKRSCFPKLEAIKSATADILTDLKKELVTLSWEDRKCSTVEVSGLDIGWGQRMPLKFDEENGSWTLQRELPEGRYEYKYIVDGEWTYNEFELVTTPNKDGHVNNFLHVVNSDPNSANGEARKRLTSDDPDLTKEERIKIRRFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWW4</accession>
    <name>A0A0D2VWW4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">B456_012G081700</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2VWW4"/>
    <dbReference type="Gramene" id="KJB76290">
        <property type="protein sequence ID" value="KJB76290"/>
        <property type="gene ID" value="B456_012G081700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1805">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NYCEAAI"/>
    <dbReference type="OrthoDB" id="306218at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18041">
        <property type="entry name" value="DEXXQc_DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22318">
        <property type="entry name" value="DNA2_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001490">
        <property type="entry name" value="DNA replication helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001170">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.320.10:FF:000001">
        <property type="entry name" value="DNA replication helicase Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051827">
        <property type="entry name" value="Cas4_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026851">
        <property type="entry name" value="Dna2/JHS1_DEXXQ-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014808">
        <property type="entry name" value="DNA_replication_fac_Dna2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531">
        <property type="entry name" value="CRISPR-ASSOCIATED EXONUCLEASE CAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36531:SF6">
        <property type="entry name" value="DNA REPLICATION ATP-DEPENDENT HELICASE_NUCLEASE DNA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08696">
        <property type="entry name" value="Dna2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0347">Helicase</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0408">Iron</keyword>
    <keyword evidence="17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Dna2 N-terminal" evidence="24">
        <location>
            <begin position="365"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="930"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="25">
        <location>
            <begin position="1033"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="26">
        <location>
            <begin position="1106"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="23">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF08696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="KJB76290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="1351" mass="149613" checksum="C23F7B334B7F83DA" modified="2015-04-29" version="1">MPPKTRRKLNPSSSKKSNVPNNQSQVQPSKFGIQHFFERHSQNALLASQKLNHLSSPPAPPSATPPTNPIPLSSPKSNAASNGVVSVSPNPNLHPSSSPAMEAADEVSPMVSKSTSLKRFNFSPGMLIKQSQDDGGDEVTWKISPVNERLLAVSKHTPVLPDSSKHNSFSIHQCSQTKGINTAAKVDKWLSSPSPKGKADKKPLLQANRIGLKRLNPFQDKEVGDSIADENTCLSSRQTPFCTPPSLPYCPDKLANGVASHPLGLKQHKKALLELLDQVEDVISVEDFVSSESEPYSSKAQEGQSKEIPVTVDSIGNDVLMGTTNKVSGTSSNGYFLVLEVSEKQTFPESGGSQCPYKVLRLVNEKSGEERAVYLWEEWSYSVIAPGDTVNVIGEFDEEGKCNVDHENNFLIVHPYILVSGTRVAGSFSCPRRTVLDERLRCNEHSTAALIGILLHQIFQAGLMKESPTVHFLEEYARIVLQKNMESLYACGVNENEIYKTLTEAIPKLVNWIALFKDTQEPQVPTVDFGSDNGAKKVKVLEVIDIEELAWAPKYGLKGMIDVSVRVKVDSGGKEGDEKIMPLEFKTGRMANGQASAEHCAQVILYSLLMSERYLKHIDSGLLYYLQSDQTQGIVVRRSDLVGLIMRRNELAHDILKALTTQQLPPMLQIPSMCKGCRHLDVCTLYHKAFGGNTESSGLGDIFDSHVHHFSNAHGVFLRHWDQLIDLEAKEMQLAKKEIWRSHNLKNENSTGCLSSLVLDELPQQGSHKENRFIYHFVCRYSPTNNLSGSDRNSIRAASSLTKDLDCSLKSGDYVILSTESGRQFVATGIIVELSPDRVSVSFSKGLRLPGGNLSSMREKLLQEVWRIDKDEIMTSFSVMRFNLIQMFLDNEQSSHLRKMIVDLAAPRFDSGCIFSQDPAISYIWSEKSLNDDQRRAILKILTAKDYALILGMPGTGKTSTMVHAVKALLMRGASILLTSYTNSAVDNLLIKLKSQGIDFVRIGRHESVHEEIKGHCFSGMNINSVEEIKLKFDQVKVVAVTCLGITSPLLSGKKFDVCIIDEAGQTTLPVSLGPLMFSSTFVLVGDHYQLPPLIQSTEAREKGMGISLFCRLSEAHSHAIAPLQSQYRMCQSIMELSNALIYGDRLRCGSPEIANAKLKFTKPIACSSWLKIVLNPSKPVIFVNTDMLPALEARDQKTVNNPMEAYIIAEITDGLVNNGIEGKDIGIITPYNSQASFIRHACKASVETHTIDRYQGRDKDCILVSFVRSNENPRSCSASLLADWHRINVALTRPKKKLIMVGSWGTLSKVPMLKLLIDKIDEQSGILSLSNDDFNHQTWALQRCSWSQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VZ21</accession>
    <name>A0A0D2VZ21_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
            <ecNumber evidence="10">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_012G134700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="10"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VZ21"/>
    <dbReference type="MEROPS" id="S10.A39"/>
    <dbReference type="Gramene" id="KJB77375">
        <property type="protein sequence ID" value="KJB77375"/>
        <property type="gene ID" value="B456_012G134700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1282">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11320:FF:000001">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12670:FF:000002">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000013">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF31">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE-LIKE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005112985" description="Carboxypeptidase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB77375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="509" mass="57423" checksum="1DD51D2F1D563874" modified="2015-04-29" version="1">MASNAAVWLGFFVLVLLSVNSEGSRHGGELSHSDVLRQQEADRVVELPGQPAVEFKQYAGYVTVNESHGRALFYWFFEATSKPEKKPLLLWLNGGPGCSSIGYGEAEELGPFFTQKDEQTLKLNPHRWNKAANLLFLESPVGVGFSYTNTSSDIHQLGDKITAEDSYIFLVNWFKRFPQFKSRDFYIAGESYAGHYVPQLAELIFDSNKIVPKSDYINFKGFMIGNALMDDETDQTGMVDYAWDHAVISDGVYSNIKIKCNFSTPNTTNGCNEAMQAYFDVYNIIDMYSLYAPTCNSNSSTSNNRQRPMIQGIAPQIFSKFVSSFSHPSLKNIGKMSRFKFESDFLQDRWHMRPAGYDPCLSDYTEVYLNRPDVQQALHANVTNISYPWTHCSDIINTWGDAPSSMLPTLKKLIAGGIRIWVFSGDTDGRIPVTATRLTLNKLGQKIIEDWTPWYTNHKQVGGWTIEYEGLMFVTIRGAGHQVPTFKPSQALQLVRHFLASKKLPPAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W305</accession>
    <name>A0A0D2W305_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_013G050300</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasmic vesicle</location>
            <location evidence="16">Clathrin-coated vesicle membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Prevacuolar compartment membrane</location>
            <topology evidence="17">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VSR (BP-80) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W305"/>
    <dbReference type="STRING" id="29730.A0A0D2W305"/>
    <dbReference type="Gramene" id="KJB79450">
        <property type="protein sequence ID" value="KJB79450"/>
        <property type="gene ID" value="B456_013G050300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783134"/>
    <dbReference type="eggNOG" id="ENOG502QSX2">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="INNCEDI"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02125">
        <property type="entry name" value="PA_VSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000178">
        <property type="entry name" value="vacuolar-sorting receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000001">
        <property type="entry name" value="Vacuolar-sorting receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056858">
        <property type="entry name" value="VSR_TRX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22702:SF1">
        <property type="entry name" value="PROTEASE-ASSOCIATED DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25011">
        <property type="entry name" value="VSR_TRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002254150" description="EGF-like domain-containing protein" evidence="19">
        <location>
            <begin position="25"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="569"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="20">
        <location>
            <begin position="501"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB79450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="628" mass="69458" checksum="E552DD3E3C621A8C" modified="2015-04-29" version="1">MELRRLLHVVLSFWLLLCIGCSDGRFVVEKNSLTVTSPEKIKGTYDSAIGNFGIPQYGGSMAGTVVYPKDNQKGCKAFDEFSISFPSKPGSLPTFVLVDRGDCFFALKVWNVQKAGASAVLVADDIEEALITMDTPEEDSSSSKYIENITIPSALIQKSFGEALKKAISGADMVNVNLDWRESVPHPDDRVEYELWTNSNDECGVKCDMLMEFVKDFKGAAQILEKGGYTQFTPHYITWYCPQAFTISKQCKSQCINHGRYCAPDPEQDFSSGYEGKDVVIENLRQLCVFKVANESNKSWLWWDYVTDFQIRCPMKEKKYNKECADAVIKSLGLDSKKIEKCMGDPNVDADNPVLKEEQDAQVGKGSRGDVTILPTLVVNNRQYRGKLAKGAVLKAICSGFEETTEPAVCLSGDVETNECLDNNGGCWQDKAANLTACKDTFRGRVCECPLVDGLQFKGDGYSHCEASGPGRCNINNGGCWHKSQDGHTYSACVDTGDVKCQCPPGFRGDGINNCEDIDECKEKKACQCPECSCKDTWGSYECTCSGDLLYIRDHDTCISKSGTEVKSAWAAVWVILIGLAMASGGAYLVYKYRLRSYMDSEIRAIMAQYMPLDSQSEVPNHVSEDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W562</accession>
    <name>A0A0D2W562_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_013G117700</name>
        <name evidence="12" type="ORF">Gorai_002820</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0602647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W562"/>
    <dbReference type="Gramene" id="KJB80844">
        <property type="protein sequence ID" value="KJB80844"/>
        <property type="gene ID" value="B456_013G117700"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB80845">
        <property type="protein sequence ID" value="KJB80845"/>
        <property type="gene ID" value="B456_013G117700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LMQVINE"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16667">
        <property type="entry name" value="RING-H2_RNF126-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000022">
        <property type="entry name" value="E3 ubiquitin-protein ligase RING1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF22">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0602647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="330" mass="36135" checksum="DA0CBAE2E4D3BB53" modified="2015-04-29" version="1">MGDRQAGRYWCYMCSRVVNPTTEPEIQCPLCDSGFLEEVGSIRSHSNINHAAIDTESPNSLSLWAPIVLGLMGSSSQLRIASRDQVTQDDELGREVESLIRRRTSSSALPLRMLQGMRTVAAASESENGGNGSGRMILFDPINDEALVVQGSFDVTNRVQTHNPSHRSAGSFGDYIMGPGWDLLLQYLSENDPNRHGTLPAWKEAVEAMPTVTVNGNVQCAICLEDIEIGNEAKEMPCEHKFHDGCIIPWLELHNSCPVCRFQLPLDDSKTEPNGNRNSGRIGTGRRYWIPIPWPYDGLVTLPGSQSESTSPPSLEAIPGSENAAQGDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W7E9</accession>
    <name>A0A0D2W7E9_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_013G189700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB82325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W7E9"/>
    <dbReference type="Gramene" id="KJB82325">
        <property type="protein sequence ID" value="KJB82325"/>
        <property type="gene ID" value="B456_013G189700"/>
    </dbReference>
    <dbReference type="OMA" id="THHMATE"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB82325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="70" mass="7722" checksum="B5B597758AE21CB9" modified="2015-04-29" version="1" fragment="single">MASEAPSWADQWGFEGIDGSNKSQGQCGFPRAKTTAFMGAKKLKLGASKAIKWVKNKSQKKKTPNEYTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2LV70</accession>
    <name>A0A0D2LV70_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bidirectional sugar transporter SWEET</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G055700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Mediates both low-affinity uptake and efflux of sugar across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cell membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SWEET sugar transporter family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SWEET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791:SF165">
        <property type="entry name" value="BIDIRECTIONAL SUGAR TRANSPORTER SWEET10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10791">
        <property type="entry name" value="RAG1-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007809"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU910715"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB07962.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="277" mass="31344" checksum="5E216564C12F82A4" modified="2015-04-29" version="1">MALHLSWVSVFGDLGVIVSFMVAFSPMPAFYQIYKKKTSEGFQSLPYVISLFSALLWIYYALLKRNEMHLIIINIFCCFIQSFYIVTYFYYGRKKEKVEAVKLMLLFNVFGSGLIFFSTYFLHNPKTRLCILGYICLGFSASTYAAPLAIVRKVIKTKSVEFMPFTLSVFLTIQAVMWFFYGLLKKDINIAGPNILGFIFGILQMILYAIYKNHPKKMVVEDPKLQLSDQLESVVSSDVNTTAPQTKDKAYNNGGGGGGDVEAQNIKKNTLDASQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M0P3</accession>
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            <fullName evidence="5">Glycine-rich protein</fullName>
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    </protein>
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_001G218500"/>
    </dbReference>
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        <property type="component" value="Chromosome 1"/>
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        <property type="entry name" value="GRP"/>
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        <property type="entry name" value="NODULIN-24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37389:SF40">
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5002247381" description="Glycine-rich protein" evidence="2">
        <location>
            <begin position="28"/>
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        </location>
    </feature>
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        <location>
            <begin position="32"/>
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        </location>
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            <begin position="32"/>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB10307.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="15068" checksum="219DDA6D22BC76AD" modified="2015-04-29" version="1">MGSISKSFLLLALLAAVVLLISSEVAARDLAETTTENNNGEVATETTQAELEDGRGGYNGRGHGGKGGYGGGHGGYGGGGHGGYGGGHGGYGGGGHGGYGGGGHGGYGGGGHGGHGGHGGGYKGGCAYGCCRSDHHGRGCQRCCSYAGEAVEVETHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M3S8</accession>
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            <fullName evidence="5">Phytocyanin domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G270000</name>
        <name evidence="7" type="ORF">Gorai_021978</name>
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    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
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        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0579732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M3S8"/>
    <dbReference type="STRING" id="29730.A0A0D2M3S8"/>
    <dbReference type="Gramene" id="KJB11652">
        <property type="protein sequence ID" value="KJB11652"/>
        <property type="gene ID" value="B456_001G270000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769536"/>
    <dbReference type="eggNOG" id="ENOG502RZRN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YKSCDIS"/>
    <dbReference type="OrthoDB" id="2331100at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04216">
        <property type="entry name" value="Phytocyanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000003">
        <property type="entry name" value="Blue copper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039391">
        <property type="entry name" value="Phytocyanin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003245">
        <property type="entry name" value="Phytocyanin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021:SF489">
        <property type="entry name" value="BASIC BLUE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33021">
        <property type="entry name" value="BLUE COPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02298">
        <property type="entry name" value="Cu_bind_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51485">
        <property type="entry name" value="PHYTOCYANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715524" description="Phytocyanin domain-containing protein" evidence="4">
        <location>
            <begin position="28"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Phytocyanin" evidence="5">
        <location>
            <begin position="28"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB11652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0579732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="167" mass="18050" checksum="6D1A32974BC071C2" modified="2015-04-29" version="1">MSLMEGMCKIFFVLVIVLPLIAKQVSATQHVVGGSQGWEESVDLNSWASAQTFKVGDQLVFKYSSGLHSVVELGSETAYKNCDLGTSLDSKNTGKDVVKLNKVGTRYFACGTLGHCDQGMKMKVTTVAGNAPSTPASDSDTSAAAFFPRYFPTFLLFSPLLILYFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M9R4</accession>
    <name>A0A0D2M9R4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_002G117500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M9R4"/>
    <dbReference type="Gramene" id="KJB14282">
        <property type="protein sequence ID" value="KJB14282"/>
        <property type="gene ID" value="B456_002G117500"/>
    </dbReference>
    <dbReference type="OMA" id="VISITCY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623">
        <property type="entry name" value="F21J9.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31623:SF33">
        <property type="entry name" value="STEMMADENINE O-ACETYLTRANSFERASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="145" mass="16846" checksum="C10579DD14D4D6A7" modified="2015-04-29" version="1">MPHIQHKQGEYINPTSSTPHHFATHKLSFLDQFVHSSYVPIVFFYVNQETNILLTDIIASNSMRSQLLKESLSQTLTLFYPFVGMIKDHLSISCNDEGAYYVEARVNLPLCVFLNLPYSSYVSQLLIFSSYVSRDLRHIQDQWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MCY6</accession>
    <name>A0A0D2MCY6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_002G189200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MCY6"/>
    <dbReference type="STRING" id="29730.A0A0D2MCY6"/>
    <dbReference type="Gramene" id="KJB15662">
        <property type="protein sequence ID" value="KJB15662"/>
        <property type="gene ID" value="B456_002G189200"/>
    </dbReference>
    <dbReference type="OMA" id="MLMKRIP"/>
    <dbReference type="OrthoDB" id="1935502at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11444">
        <property type="entry name" value="bHLH_AtIBH1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044549">
        <property type="entry name" value="bHLH_AtIBH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044660">
        <property type="entry name" value="IBH1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124">
        <property type="entry name" value="TRANSCRIPTION FACTOR IBH1-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33124:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR UPBEAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13691" checksum="846E073B2B4B8319" modified="2015-04-29" version="1">MGISPLPLLSLDCNDLMSESKRRLKVKKQRVWGKTVKRHWRCRRRSRSMLMKRIPEGCTRTLNPFQKKVKTLKKLIPNKESMGLGGLFRDTAEYIMCLQKRVKVMQIMVKVLTGSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MP23</accession>
    <name>A0A0D2MP23_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G1484002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MP23"/>
    <dbReference type="Gramene" id="KJB20442">
        <property type="protein sequence ID" value="KJB20442"/>
        <property type="gene ID" value="B456_003G1484002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QWP8">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ININFPF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00303">
        <property type="entry name" value="retropepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056648">
        <property type="entry name" value="DUF7746"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018061">
        <property type="entry name" value="Retropepsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33054">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33054:SF9">
        <property type="entry name" value="CCHC-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22909">
        <property type="entry name" value="Caulimovir_coat_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24925">
        <property type="entry name" value="DUF7746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00077">
        <property type="entry name" value="RVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="4">
        <location>
            <begin position="497"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="651"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB20442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="792" mass="92339" checksum="3AE4C36F987DEC2B" modified="2015-04-29" version="1" fragment="single">SVNTIRHNTIWQTNKGEVESRHPPLMEVQYLHKNTGIKANPLRIRAPDAGEQISSKDIKMIVEQNNYININLHTIGKQLDYVENLVESQPIKREPVKEITEKSSKEPIFTPYEIPKAFQKSQNDFLTEIQNRLHALKNHKSELIAPDTPIQTQYSVNTLHQSSQSDSDQSDEQQINKMAWKEPKRLYYPKITAPDLNIEEKPVFQNKYNANTIYEWNIDGMSEYNILSLLQQMTMVSNVYKTQNQNGLINDHAIANLLVAGFTGQLKGWWDHALTKTQQEEILKAIKKDDQDRIILDEQGREIQDAVATLIFSISKNFIGDPSHLKDRNSELLSNLKCKKLTDFKWYKDVFMTRVMQRSDNQQPFWKEKFLAGLPTLLGEKVRNQIRENYKGIIPYEKLTYGELISFTQKEGLKICQDLKLQKQLKKERYQCRKELGSFCHQFDIRNEPSSSKTCCPEKQKNRKNNISEYYKKPKYKKYRKGKKQQKTENKIDKTIKCYRCGKPGHISKYCKIKRKINNLNLEEEIEQKLNEILLETTSSENDTSTETDELQIDELHTTSQSSGDENEPSINMLTKDQEFMIEVIDKIQDLELKREYLLKLKSSLKDKPEKEKEIISSQSQIQITNSELQLEIKQIKSELSQLKIEQQEMKEQIRSLKHETSEKSSSETEHEPEENTQEYMMVLTEVSIQRYLIKINIVINNEFQLETNALFDTGADQNCIREGIIPTKYYNKTSESLKAANEISNKGIKYQTCFLMVKDITQDVILGTPFISLLKPYKVTNNSISTKKNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MP68</accession>
    <name>A0A0D2MP68_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_003G151200</name>
        <name evidence="3" type="ORF">Gorai_024846</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the plant acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB20487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000003">
        <property type="protein sequence ID" value="MBA0582712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MP68"/>
    <dbReference type="STRING" id="29730.A0A0D2MP68"/>
    <dbReference type="Gramene" id="KJB20487">
        <property type="protein sequence ID" value="KJB20487"/>
        <property type="gene ID" value="B456_003G151200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789049"/>
    <dbReference type="eggNOG" id="ENOG502RBEP">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YFPNCVL"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050898">
        <property type="entry name" value="Plant_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147">
        <property type="entry name" value="ACYL TRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31147:SF25">
        <property type="entry name" value="HXXXD-TYPE ACYL-TRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB20487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0582712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="460" mass="50771" checksum="88EFC1955CBF5E72" modified="2015-04-29" version="1">MATHSSIMFSVDRKDIAFVKPSKPTPSHLLSLSTIDNDLNLELMCHTVFVYQSNADFCTKGEEIKDPASIIKEALSNLLVYYYPLAGKMKRETDGKLRITCNTDDGVPFLVATANCKLSSLNYLDGIDVKTGKEFALDFPSESDDGYHPLVMQVTKFVCGGFTIALSLSHSVCDGFGAAQVFQALAELASGNNEPSVKPVWDRHLLVAKPIEAIPSDMLDKASSATSPYLPSTDIVHDCFYVTDDSIKTLKMNLIKESKDETVTSLEVLSAYIWRARFRALKLNPDGKTIFSMAVGMRRTVKPPLPEGYYGNAFTAANASMTGKELNEGSLTKAVKQIKEGKKLATNNDYIWNLMSINEKLRELNMKFEAASGATMVITDWRRLGLVEDIDFGWKGCVNMIPLPWNMFGYVDLVFLLPPCKLDQSMKGGARVLVSLPRAAIAKFREEMDALKHGDDAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MUH0</accession>
    <name>A0A0D2MUH0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G063100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUH0"/>
    <dbReference type="STRING" id="29730.A0A0D2MUH0"/>
    <dbReference type="Gramene" id="KJB22727">
        <property type="protein sequence ID" value="KJB22727"/>
        <property type="gene ID" value="B456_004G063100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793534"/>
    <dbReference type="eggNOG" id="KOG1404">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YQNFPKT"/>
    <dbReference type="OrthoDB" id="425114at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009448">
        <property type="term" value="P:gamma-aminobutyric acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000014">
        <property type="entry name" value="Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, probable"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004767">
        <property type="entry name" value="PRK06105.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42684:SF3">
        <property type="entry name" value="ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB22727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="502" mass="55556" checksum="F1F2A3556288B111" modified="2015-04-29" version="1">MVSNKYLRSTLKTQLGSYIKNAAACKSLLEYPIKGQCEARWCSTNTCFKGHNMLAPFTPGWQSTEVNPLVIVKSEGSYVYDINEKKYLDTLAGLWCTALGGNEPRLVAAATDQLNKLPFYHSFWNRTTKPSLDLAKELTETFTATKMAKVFFTNSGSEANDTQVKLVWYYNNALGRPKKKKFIARAKAYHGSTWISASLSGLPPLHQNFDLPPPFVLHTDCPHYWRYHLPGETEEDFSTRLANNLENLILKEGPETIAAFIAEPVMGAGGVIPPPATYFEKVQAVVNKYDILFIADEVISAFGRLGTMFGCDKYNIKPDLVSLAKALSSGYMPIGAVMVSPQVTEVVYSQSNKLGNFSHGFTYTGHPVACAVASESIKLYKERNIVEKVKSISPRFQDGLKSFSDSPIVGEIRGTGLILSTEFTDKKSPNEPFPPEWGIGAYFGGQCEKQGMLVRVAGDTIMMSPPFIISPKEVDELISKYGNALKATEEKVNSLKSQHNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N103</accession>
    <name>A0A0D2N103_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Agenet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G197800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2N103"/>
    <dbReference type="Gramene" id="KJB25567">
        <property type="protein sequence ID" value="KJB25567"/>
        <property type="gene ID" value="B456_004G197800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792061"/>
    <dbReference type="eggNOG" id="KOG1181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DNKSFAD"/>
    <dbReference type="OrthoDB" id="433924at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20405">
        <property type="entry name" value="Tudor_Agenet_AtDUF_rpt1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20403">
        <property type="entry name" value="Tudor_Agenet_FMRP-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008395">
        <property type="entry name" value="Agenet-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014002">
        <property type="entry name" value="Agenet_dom_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055274">
        <property type="entry name" value="SWO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48429:SF1">
        <property type="entry name" value="AGENET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05641">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00743">
        <property type="entry name" value="Agenet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1680"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="domain" description="Agenet" evidence="2">
        <location>
            <begin position="1770"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1836"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="2038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2065"/>
            <end position="2168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="751"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="914"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1229"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1631"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1845"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1864"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1949"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="1988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2126"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2159"/>
            <end position="2168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB25567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="2168" mass="231518" checksum="30478227395DE654" modified="2015-04-29" version="1">MDNDENDSQSHNCHLAGEGNNKFPPVLRPYALPRFDFDDNLHGHLRFHSLVETEVFLGIESSEDNQWIEDFSRGGTGIAFSSSAAESCSISRCNNVWSEAASSESVEMLLKSVGQDETIPVQTICKNSDACDELGCIINQMEPTLKHGDRGLPKVGDDLQPALQSGECPGKLPGLKDDIGGDHLLVEDVSQTHEFGTSVDSTLDDLNTRNTDLPVTKRDDSKEHTVNESLVEASVDQSVDDREQEDKCTGSQVDAVIHSVQNTYASNALIDSQDTTHLKHDLIDENVDGSANQNVDLSQEVQTDGQNVSENAVASVTLLAQKNSALDMHSKEERHAIGNITTAGEPVDRISKGNSNLHMVEGCSEGLRVESPLRTTISEDIVLSERKLHDISPMPFVGDTDLKELGSEVSNMDTRNPMSLESNMDSTVQIACDTLEKKDSSDGDGHPDMKILSSKSEKSLVVDDNGSKGEGEGSHNTLGTEPMKECEESIVVEHSDDYKSDQTVSTAANQNTKLSSDSSNTDCGEGGSVPVIKGVDFSSSGTGRTADELASVLQSDVAISGKSMECVLSPSGKDLPAATAVVSDQNKVQVSSAETSFSIMNTSGMTSEKGAPCETSGQSSCSKVDQSLSMEGTSIDEGQHGDQAIHGLSVEVVRDKHVSSIIPDSTVRGTDGAEAQVISKTGSSEAAGAVSIQQNNQTSTSSLPSTSKEPTCDSGQNHPEDTDPKLVTKEKNSDHVAKHHVDGGRAKTDNSSFPSAPSSESQTKIHMMGSGSSSADLDNPSCGSPIVIRTSEQFPSKIGNDGLKGSEGRSASISGVINGEENKDQSISEDMKGNYASPGDRTFTFEVPPLADLSGKEAGKNWQLFSTMQHDTISSVEGTLSTASLSKVGTKAAQEVSHANLQASKSENVRGRSKGTSEGSGSKGTSERRARRVGGKSTGKEAAKKGIAAKEMTPASRSKRSGRTSNASLSSAGIGQLIQSNEVKHSGHMEGATTKPFGVLSTSVSSLPDLNASASSSAVFHQPFTDLQQVQLRAQIFVYGALIQGTAPDEAYMISAFGGLDGGRTMWENAWRACIDRVHSQKSHLVSPETPMQTPLGAKTSDQSVKRNALQNKVTSSPVSRSTSKGTPTTIVNSMVPLSSPLWSISAPSCDALQSTGIPRSAVMDYQQALSPLRPPPIRNFVGHNAPWMSQSPFRVPWVPQTSSFDARFPVLPITEAVNLTPAREASVPHSSAMKQASTVPMVQSGSPANVFAGTPLLDTKKATATRGQHSADPKPRKRKKSTVSEDPGQIKPHSQSESVSATVVTSNVSTPAAITTLATVVSKSSTDKFVTSVPVDHLEKGEQDSDQRVALSEETFGKLQEAQKQAEDASTLAAAAVHHSQEIWTQLGKHRNSGLEPDFETELTSAAVAIAAAASVAKAAAAAAKVASNAALQAKLMADEALVSSGYKNSVPTNAIASDNVKKLGKATPASILRGENATTSSNSIIIAAREAARRRVEAASAASKRAENMDAIVKAAELAAEAVSQAGKIVAMGEPFPLTELVEAGPEAYWKVPQASPEPNGSIREHIDSGRVEGPTSSAGHLKEVQVEKREKQSVEYGMSPTLREIARESLEDHSRLTGGILGPTAASGKDKKGPKGHKASEIAKTKGVTSESEIGFGLPSVITQSEHGKAGETSKNNNLREGSHVEVLRDGDGLKVAWFPADILDLKDGKAYVCYNELRSEDGDKLKEWVELEGEGERAPRIRTARPVTAMPFEGTRKRRRAAMGDYNWAPGDRVDSWMQDSWWEGVVTEKSQTDETSFTVHFPARGETSVVKAWFLRPSLIWKNGSWVEGSSFQDTNGSSHEGDTPQEKRPRIGGPVVEARGEDKLSKSLDRKESWKPGDMRLLDLSDNEKIFNIGRSTRDENKPDSLKMVRTGLKKEGSRVIFGVPKPGKKRKFMEVSKHYVADQSGKTHETSDSAKFTKYLMPQGSEPRETKNKIEPKDKRAAVYRPKVLKSGKPPSVSSRTIPKKDSLSNTLVSEPGDSAAADVSHAENISGKHNIMEFRSFSSTDGAAKGPVLFSSVAFSSDAPPKKNSASNAKSERVSKPKLGPASGKLAKIEEEKGSNDNSIKTVSEVEPRRSNRKIQPTSRLLEGLQSSLIISKIPSVSHDRSHKSQNRSSRGNNQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9C6</accession>
    <name>A0A0D2N9C6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_001G138400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9C6"/>
    <dbReference type="Gramene" id="KJB09388">
        <property type="protein sequence ID" value="KJB09388"/>
        <property type="gene ID" value="B456_001G138400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794208"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WPEVSEM"/>
    <dbReference type="OrthoDB" id="1887476at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000381">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000682">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g16610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000343">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At3g58590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000073">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046849">
        <property type="entry name" value="E2_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015:SF1903">
        <property type="entry name" value="OS05G0305300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24015">
        <property type="entry name" value="OS07G0578800 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20430">
        <property type="entry name" value="Eplus_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="117"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="422"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="523"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="625"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="660"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB09388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="855" mass="95973" checksum="2E6BAA0FCE09DDEC" modified="2015-04-29" version="1">MLISLQTLHFTPKNETNKAWNSIIKHQTKLKNDHAILSTFTHMQSLGLTPDKASLPLVLKACRKLNAIETGKRIHSSIRDTNLIEDVRVGTALIDFYSKCGFLEDARKVFDEMSERDLVSWNAMISGYAGCEEFEEVVFLVMTMQREGFRPNSRTLVAMILVCDKVAEVRLGKAIHGYCLRNGLFDLDAHVGTALISFYLSFFDVRASHLVFDLMAIRNTVCWNAMIMGYFDVGESSKALRLFEQMLMDGVEFDSVTVLALIQASAEFGSLELGDQIHQMAIKCSYSNDLFIVNALINMYAEIGCLKSACKLFDGIPTRDVALWNSMISAYIDYSYHGEAISLFIKMRTEGNKEDERTTVLMLSLCAESADALRKGRSLHAHACKTGMGMDINIGNAILNMYAEQNCMDSVRKVFGQMSNVDVISYNTLILVLARNNLGIEAWETFGIMRESDVKPNSYTIISILAACKDETCLNIGRSLHGFVIKQGIEVNAPLKTALTDMYINCGDETTAMKLFESSHGRDLISWNALISTYVKNNQAHEAFLVFSRMVSEVEPNSVTIINILSSCTHLAHLPQGRCLHSYMIQRESSLGRNLSLQNAFITMYARCGSMRNAEKIFETLTRRNIISWNAIITGYGMHGRGYDAILAYSQMLEDGFQPNEVTFISILSACSHSGMIEEGLQLFDSMVHDFNITPQLAHYGCVVDLLGRAGRLDKAREFIESMPIKPDASIWRSLLSAYRDHCYTKDAKAIFEKVVELDPMNPGNHVLLCNVYAAAGLWPEVSEMRRHLRAKGLRKPPGISWIVVRSQIHSFAAGDRSHPMADKIYANLNSLLQSIKEIGYVPDLHWILHDDEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NB54</accession>
    <name>A0A0D2NB54_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_001G183900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Cytokinin-activating enzyme working in the direct activation pathway. Phosphoribohydrolase that converts inactive cytokinin nucleotides to the biologically active free-base forms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 9">
            <text>N(6)-(dimethylallyl)adenosine 5'-phosphate + H2O = N(6)-dimethylallyladenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NB54"/>
    <dbReference type="STRING" id="29730.A0A0D2NB54"/>
    <dbReference type="Gramene" id="KJB10103">
        <property type="protein sequence ID" value="KJB10103"/>
        <property type="gene ID" value="B456_001G183900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QRUW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF14">
        <property type="entry name" value="CYTOKININ RIBOSIDE 5'-MONOPHOSPHATE PHOSPHORIBOHYDROLASE LOG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00006763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB10103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="190" mass="21328" checksum="806BCE450776AD7F" modified="2015-04-29" version="1">MEGEVVKSRFKRVCVFCGSRTGKRKCYTDVAVELGQEWVHPKLLPDISLNPVSFLYVSLKGFFSPLCCFWKGGKKFGPCLWWSIRLMGIVSKTVHRAGGNVIGIIPSTLMRKETHITGETVGEVRPVGNMNQRREAMANHSDCFIALPSGYGTLEELLEVITWVQLGIHDKPISNNNMVIVELLRGYLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NB84</accession>
    <name>A0A0D2NB84_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G185800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NB84"/>
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        <property type="protein sequence ID" value="KJB10138"/>
        <property type="gene ID" value="B456_001G185800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="85" mass="9913" checksum="1AAC405F03AE1E8F" modified="2015-04-29" version="1">MWYNFPVTLDHPSSLSYLFSKLFAYSNLPKSSKDYIENTIPLQSLSTSSLTYLGNLFLKQHRSPFFRPSIASKYLIYQHILSVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P792</accession>
    <name>A0A0D2P792_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_004G053400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2P792"/>
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        <property type="gene ID" value="B456_004G053400"/>
    </dbReference>
    <dbReference type="OMA" id="MAICFPP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB22543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="50" mass="5392" checksum="7844E930F4ECBA16" modified="2015-04-29" version="1">MGKVICSELKEGNSLGFTGFLMVLVIALALMAICFPPPPRRAVLVARRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2P7P1</accession>
    <name>A0A0D2P7P1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G062800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
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                <person name="Tang H."/>
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                <person name="Wang Z."/>
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                <person name="Zhang L."/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25175">
        <property type="entry name" value="Beta-prop_WDR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR5-like beta-propeller" evidence="4">
        <location>
            <begin position="26"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="157"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB43997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="MBA0590640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="325" mass="35526" checksum="F4AABD8F8D0D3181" modified="2015-04-29" version="1">MATVATTTTSTAATTETFKPYTLSQTLAVHKNALSSVKFSSDGSLLASSSADKTLRTYSLSPTASTLTPIHEYSGHDQGVSDVAFSSDSRFLVSASDDKTLRLWDVPTGSLIKTLHGHTNYVFCVNFNPQSNMIVSGSFDETVRVWDVKTGKCLKVLPAHSDPVTAVDFNRDGSLIVSSSYDGLCRIWDAGTGHCMKTLIDDENPPVSYVKFSPNGKFILVGTLDNTLRLWNFETGKFLKTYTGHVNSKFCISSSFSITNGKYIVSGSEDNCVYLWELQSRKVVQKLEGHTDAVISVACHPTRNMIASASLGNDKTVRIWTQEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PL18</accession>
    <name>A0A0D2PL18_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G017300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB46787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PL18"/>
    <dbReference type="STRING" id="29730.A0A0D2PL18"/>
    <dbReference type="Gramene" id="KJB46787">
        <property type="protein sequence ID" value="KJB46787"/>
        <property type="gene ID" value="B456_008G017300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1750">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TCGFEIT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB46787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="11133" checksum="459E2D34DFF70D9D" modified="2015-04-29" version="1">MESVQLEHENVTEFVLVTLRDRVEEGRRFSNEEKDPMTSKELSEDKGDLSVNFFTITPNKPNSALRKVARVRLTCGFEITAYIPGIGHNSQEHSIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PLZ7</accession>
    <name>A0A0D2PLZ7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G026000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-glycosyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PLZ7"/>
    <dbReference type="STRING" id="29730.A0A0D2PLZ7"/>
    <dbReference type="Gramene" id="KJB28078">
        <property type="protein sequence ID" value="KJB28078"/>
        <property type="gene ID" value="B456_005G026000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1192">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RCIMIAM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080043">
        <property type="term" value="F:quercetin 3-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080044">
        <property type="term" value="F:quercetin 7-O-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926">
        <property type="entry name" value="GLUCOSYL/GLUCURONOSYL TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11926:SF870">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 75B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB28078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="140" mass="15609" checksum="32D2A96EE6C649A3" modified="2015-04-29" version="1" fragment="single">LLSSRQPFSWVVRNWKDGGYEEREKDKLTFREELEQLGMVVPWCSQVEVLSHLYQGTNAKLIEDVGGMGVRVSANEEGIMERDEIVRCLGLVMGDGEKGMQVKKNVEKWKGLAGEAAMEGGSLDINLKVFVDDVAQGCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PM60</accession>
    <name>A0A0D2PM60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_001G055000</name>
        <name evidence="5" type="ORF">Gorai_020603</name>
    </gene>
    <organism evidence="4 6">
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                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
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                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
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                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB10514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="131" mass="14800" checksum="6E1A59A989447707" modified="2015-04-29" version="1">MENACQALDNGDNSGNLNMTIFRQIKHVYIYGGVYGKERELRTSLLTRKQPNTGSKETSLDEVLCRHKERKPFAYGLCNEYYEEFMKVSGGLDGGSDPPAFQRAEKERLAKLSIEENAKVCSVIILYKGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PV60</accession>
    <name>A0A0D2PV60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_001G064900</name>
        <name evidence="13" type="ORF">Gorai_020664</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the AP2/ERF transcription factor family. ERF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PV60"/>
    <dbReference type="STRING" id="29730.A0A0D2PV60"/>
    <dbReference type="Gramene" id="KJB08101">
        <property type="protein sequence ID" value="KJB08101"/>
        <property type="gene ID" value="B456_001G064900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105770431"/>
    <dbReference type="eggNOG" id="ENOG502S0HI">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MKNHALS"/>
    <dbReference type="OrthoDB" id="773121at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009873">
        <property type="term" value="P:ethylene-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00018">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.730.10:FF:000005">
        <property type="entry name" value="ethylene-responsive transcription factor RAP2-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.730.10">
        <property type="entry name" value="AP2/ERF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036955">
        <property type="entry name" value="AP2/ERF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050913">
        <property type="entry name" value="AP2/ERF_ERF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016177">
        <property type="entry name" value="DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194:SF82">
        <property type="entry name" value="AP2_ERF DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31194">
        <property type="entry name" value="SHN SHINE , DNA BINDING / TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00367">
        <property type="entry name" value="ETHRSPELEMNT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00380">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54171">
        <property type="entry name" value="DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51032">
        <property type="entry name" value="AP2_ERF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0936">Ethylene signaling pathway</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="11">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0578381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="216" mass="24499" checksum="59F4DF4A4A28EA15" modified="2015-04-29" version="1">MVPQQDQSPNKNQTSIEPHEAQTMAENSEKRSIKKVINNGRRRYLGVRQRPSGRWVAEIKNSSQKLRLWLGTFDKPEEAALAYDNAAMVLRGKNAKTNFQYEGNLNLIGKVNINPRVYQLLQLTIMKNHARSALRSINGKRMDPVDIDGFDTIVEETIFCDDHHHHHDHDEGDNNNNNNKLCKVSLGNSKVYSSVVVAPSFCSSSIDQQGQKENNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q113</accession>
    <name>A0A0D2Q113_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_002G051100</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q113"/>
    <dbReference type="Gramene" id="KJB13014">
        <property type="protein sequence ID" value="KJB13014"/>
        <property type="gene ID" value="B456_002G051100"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KVDYCLR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000317">
        <property type="entry name" value="Inactive leucine-rich repeat receptor-like protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000661">
        <property type="entry name" value="Serine-threonine protein kinase plant-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051809">
        <property type="entry name" value="Plant_receptor-like_S/T_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008">
        <property type="entry name" value="OS04G0122200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR27008:SF585">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="498"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="783" mass="86798" checksum="64561D16BAF4BF1E" modified="2015-04-29" version="1">MAGIIPHEIGNLNNLNWLNLAFNNIAGSIPPQVFNISTLRMISLDTNQLSGHLPSNMGPFLPNMEQLYLDFNHLAGSIPMYISNASQLTVLDMSNNYFSGSIPDNLGNLRNLKFLDLAGNNLTSSGMSFLFSLTNCRVLEKFLFDSNPFISGELPRVVGNVSISLEEFSAYSCNIRGSIPNEIGNLSHLISIDLGGNKLIGQIPTTIGGLEELQSLSLEDNKLEGSIPSQLCHLNKLAFLFLTNNQLSGPIPACLGDLTSLRQLGLDSNMFSSSIPSTLTRLNYLLILYLSSNSLSGPLPIDIGKWKVLTSLDLSNNQFSGDIPTGVADLKDLTHFSLSNNRIMGSIPESFDELLSLEFLDLSRNNLSGEIPKSLEKLRYLKYFSVSFNRLEGEIPEGGSFGNYTIESFKGNEALCGAARLHVPNCKTRPLRNSKAKTKLITYVAPPIASTILVVVLVIIILQNSRRKDKLSPQEDMIPLGTWRRFSFHELRQATDGFNDSRLLGNGSYGSVFQGTLPDGMIIAVKVFKLELEGAFKSFDVECDVLRNTRHRNLVKVISSCSNDLNFKALVLEFMPNGSLDKWLYFNKQYLDILQRLNIMIDVASALEYLHHGNATPVVHCDLKPNNVLLDEDMVAHLSDFGIAKLLCEEVSMIQTMTMATFGYMAPEYGTEGVVSTKGDVYSFGIFLMEIITRKKPTDEMFAGERSLKSWVKESISSSVNRVVDTNLLSTIGKEHFAAKNCVLSILEVGLECCVELPNERLHMKEIVTKLKKIKVKLLRDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q159</accession>
    <name>A0A0D2Q159_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G0553001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q159"/>
    <dbReference type="Gramene" id="KJB13074">
        <property type="protein sequence ID" value="KJB13074"/>
        <property type="gene ID" value="B456_002G0553001"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1441">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQTIRFR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="72"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB13074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="183" mass="19980" checksum="F56359A870FF8A9B" modified="2015-04-29" version="1" fragment="single">MLQLGAGSGVSRLRSSSLKKPPEPLRHAVADCLSSSSLAAVVGGVSSHHQGGPLILTEASRTLRYLLSNYGFKYPIFLTMCHMTACSLLSYFAIAWMKMVPMQTIRSRVQFFKITTLSLVFCVSVLFGNISLRYLPVSFNQAIGATTPFFTAVFAYLMTLKREGWLTYITLVPVVTGVIIASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q169</accession>
    <name>A0A0D2Q169_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G245900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the HIPP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q169"/>
    <dbReference type="STRING" id="29730.A0A0D2Q169"/>
    <dbReference type="Gramene" id="KJB52082">
        <property type="protein sequence ID" value="KJB52082"/>
        <property type="gene ID" value="B456_008G245900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1603">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMNDEKT"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051863">
        <property type="entry name" value="HIPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45811:SF22">
        <property type="entry name" value="UPF0329 PROTEIN ECU05_1680_ECU11_0050-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="6">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB52082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="110" mass="12489" checksum="4F56D6B87665F19B" modified="2015-04-29" version="1" fragment="single">FVLHILEFLKVVLKIMTMNDEKTKKKAIEAVADIYGVDSIAADVKEQKLTVIGEMDTVAIAKKLKKIGKVDIVTVGPAKEEKKDEKKTKRRVKKRNDYQNLKLVLSAFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q1Z6</accession>
    <name>A0A0D2Q1Z6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Expansin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_002G071600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q1Z6"/>
    <dbReference type="STRING" id="29730.A0A0D2Q1Z6"/>
    <dbReference type="Gramene" id="KJB13384">
        <property type="protein sequence ID" value="KJB13384"/>
        <property type="gene ID" value="B456_002G071600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105787177"/>
    <dbReference type="eggNOG" id="ENOG502QSIV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AMHRNWG"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="9">
        <location>
            <begin position="46"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="10">
        <location>
            <begin position="167"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="252" mass="28060" checksum="2152CE720948B696" modified="2015-04-29" version="1">MGPFIIPFVKVWLLFFIVGTIFGAVNGWFNAHATFYGADQSPFSLGGACGYDNTLHAGFGANTAALSGALFRDGEACGACYQLRCDYRADPKWCLRRASVTITATNFCPSNNNGGWCNPPHHHFDMSLPAFLRIARHGDEGIVPVLYRRVPCKRRGGVRFTLKGQSSFNMVMITNVGGSGNVKAAWIRGSRTRTWLPMNRNWGANWQSSIDLRNQRLSFKLTLVDGKTLEFLNVVPSTWKFGQTFASIRQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q368</accession>
    <name>A0A0D2Q368_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RHOMBOID-like protein</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_008G279300</name>
        <name evidence="13" type="ORF">Gorai_010613</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q368"/>
    <dbReference type="STRING" id="29730.A0A0D2Q368"/>
    <dbReference type="Gramene" id="KJB52822">
        <property type="protein sequence ID" value="KJB52822"/>
        <property type="gene ID" value="B456_008G279300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765565"/>
    <dbReference type="eggNOG" id="KOG2289">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DGNEYCT"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1540.10:FF:000019">
        <property type="entry name" value="RHOMBOID-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF86">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="118"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB52822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0593678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="333" mass="36678" checksum="52A1094D0883769E" modified="2015-04-29" version="1">MAGGDIENRGGGAKSYSNSINDSSGGSFISSSTYMIDDTEPQWTSWLVPVFLVANVAVFVVVMYVNNCPKHKLVGKCVARFLGRFSFEPLRENPLFGPSSSTLKKLGALEWTKVVINHQGWRLITCIWLHAGVIHLLANMLSLIFIGIRLEQQFGFVRIGILYLVSGFGGSVLSSLFIRNNISVGASGALFGLLGAMLSELITNWTIYTNKASALLTLVVIIVINLAIGIFPHIDNFTHIGGFLTGFLLGFILLPRPQLGWLEHGNIPVRTGLKSKYKPHQYVLWVASIVLLVVGLAVALVVLFREEDGNEYCTWCHYLSCVPTSRWDCNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q4D9</accession>
    <name>A0A0D2Q4D9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transport and Golgi organization protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_002G115300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2Q4D9"/>
    <dbReference type="SMR" id="A0A0D2Q4D9"/>
    <dbReference type="Gramene" id="KJB14209">
        <property type="protein sequence ID" value="KJB14209"/>
        <property type="gene ID" value="B456_002G115300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105783555"/>
    <dbReference type="eggNOG" id="KOG2342">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RIFHFEL"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB14209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="30215" checksum="05553DFB56B7CC21" modified="2015-04-29" version="1">MCIAAFIWQAHPLYPLLLLQNRDEYHNRPTKALAWWDVDGCEILGGRDEVAGGTWLACSRQGRVAFLTNVLELHPRPDAKTRGDLPLLFLESTKSPMEFAEQLATDAHQYNGFNLIVADIPSKSMVYISNRPKGEPINIQQVSPGLHVLSNAKLDSPWHKAQRLGKGFKQMLNRYGKNEVNVKEMVEKLMKDKVKADKSKLPGICALDMEFNLSSIFVEMDTPLGLYGTRSTAAMTVGAGGEVSFYDKYLEKGVWFERTVNYHIQKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5S7</accession>
    <name>A0A0D2Q5S7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bet v I/Major latex protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G177600</name>
        <name evidence="3" type="ORF">Gorai_023143</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
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        </citation>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
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                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        <source>
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        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Gundlach H."/>
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                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Reddy U.K."/>
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                <person name="Zaki E.A."/>
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                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Aux/IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimers and heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Aux/IAA family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB38278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QG49"/>
    <dbReference type="STRING" id="29730.A0A0D2QG49"/>
    <dbReference type="Gramene" id="KJB38278">
        <property type="protein sequence ID" value="KJB38278"/>
        <property type="gene ID" value="B456_006G246000"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPNB">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009734">
        <property type="term" value="P:auxin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000078">
        <property type="entry name" value="Auxin-responsive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033389">
        <property type="entry name" value="AUX/IAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003311">
        <property type="entry name" value="AUX_IAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734:SF260">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31734">
        <property type="entry name" value="AUXIN-RESPONSIVE PROTEIN IAA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02309">
        <property type="entry name" value="AUX_IAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0927">Auxin signaling pathway</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0678">Repressor</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PB1" evidence="10">
        <location>
            <begin position="176"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB38278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="294" mass="32355" checksum="B7BFFE4072ECACDF" modified="2015-04-29" version="1">MMSLQKKLKHCVNEIKEQGETEAKAIQIGSKDRSKKRVEASCFVSMEVGRKMANMLGTDHDLNFKETELCLGLPGGIAVVAAGNETESSSSPKTNGKRGFSETVDLKLNLQSKESTMDLNKNLDDNGSKEKSGSAKDPAKPPAKAQVVGWPPVRSYRKNIMANQKNSSEESGNSGAALVKVSMDGAPYLRKVDLKMYKSYQELSDALAKMFSSFTMGNYGPQGMIDFMNESKLMDLLNSSDYVPSYEDKDGDWMLVGDVPWQMFVDSCKRLRIMKGSEAIGLAPRAMEKCKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QHY5</accession>
    <name>A0A0D2QHY5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G005800</name>
        <name evidence="3" type="ORF">Gorai_017652</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB38918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0588874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QHY5"/>
    <dbReference type="Gramene" id="KJB38918">
        <property type="protein sequence ID" value="KJB38918"/>
        <property type="gene ID" value="B456_007G005800"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB38918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0588874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="83" mass="9434" checksum="03E7ED755EDCBF28" modified="2015-04-29" version="1">MAKRKRRNIVPANRRAESTVQPQKHQSMPPQHEQQSLEQLAFEVQGPNKKGHGGCVGAVASSSRLRLVLRIFNQCKEMKNERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLW9</accession>
    <name>A0A0D2QLW9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_001G075100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QLW9"/>
    <dbReference type="STRING" id="29730.A0A0D2QLW9"/>
    <dbReference type="Gramene" id="KJB08285">
        <property type="protein sequence ID" value="KJB08285"/>
        <property type="gene ID" value="B456_001G075100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3320">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
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        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF29">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7Z"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF01251">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB08285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="244" mass="27915" checksum="05DD58C8129932C0" modified="2015-04-29" version="1">MVEVFKNLTTHCAVSLHSPAVKQASQQPFLPLLLLLFSPSPVPEQARPVIQIRMYTSMMKIHKDKDVEPTEFEESVAQAFFDLENTNQDLKSDLKDLYINSAVQIDVSGSRKAVVIHVPYRLRKAFRKVHVKLVRELEKKFSGKDVILIATRRILRPPKKGSAVQRPRSRTLTAVHEAMLEDIVLPAEIVGKRTRYRIDGSKIMKVFLDPKERNNTEYKLETFSAVYRKLAGKDVVFEFPVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNK0</accession>
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        <recommendedName>
            <fullName evidence="10">PGG domain-containing protein</fullName>
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    <gene>
        <name evidence="11" type="ORF">B456_001G107200</name>
        <name evidence="12" type="ORF">Gorai_020963</name>
    </gene>
    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB08840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000001">
        <property type="protein sequence ID" value="MBA0578689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QNK0"/>
    <dbReference type="STRING" id="29730.A0A0D2QNK0"/>
    <dbReference type="Gramene" id="KJB08840">
        <property type="protein sequence ID" value="KJB08840"/>
        <property type="gene ID" value="B456_001G107200"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026961">
        <property type="entry name" value="PGG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186:SF18">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24186">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13962">
        <property type="entry name" value="PGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="161"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="PGG" evidence="10">
        <location>
            <begin position="378"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB08840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0578689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="571" mass="62269" checksum="DBAEA524F01E1FF4" modified="2015-04-29" version="1">MERPTTEQPSVPARRKKMTKQLTGKRDDTALHSAARAGNLAAVKEILTGIEEDALKEQLAKQNQSGETALYVAAEYGYVDLVKEMINYYDLVNAGIKARNGFDALHIAAKQGDLGMFPTPELSVFGFLEVKIRFSRVTLVADILKVLLAAHPELAMTVDLSNTTALHTAATQGHLENVKFLLEVGSSLAIIARSNGKTPLHSAARNGHLDVVKALLACEPGIAPRIDKKGQTALHMAVKGQSLAVVEELIRVNPSLMINMVDTKGNTSLHIATRKGRAQIVKLLLGYKETDIKAVNRCGETAFDIAEKTGNLEIASMLQQHGVQSARAIKPAATNPARELKQTVSDIKHEVHYQLEHTLQTRKQVQGIAKRINKMHSEGLNNAINSTTVVAVLIATVAFAAIFTVPGQYVDDPNDIPPGDSLGEANIAPKPAFIIFFIFDSIALFISLAVVVVQTSVVVIDSKGKKQMMAIINKLMWLACVLVSVAFLALSFIVVGKDEKWLAIGVTIIGTSIMATTLGTMCYWVIRHRIEASNMRSIRRSSQASRSRSWTMSVMSDSEILNNEFKKMYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QP00</accession>
    <name>A0A0D2QP00_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_003G063800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QQ79</accession>
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        <name type="scientific">Gossypium raimondii</name>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
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                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="96" mass="11168" checksum="E6F4E8A08269CA37" modified="2015-04-29" version="1">MEGRSNSSCNNPPAQAQAVSELETLQKVHEEKTQKIQHLNTQIQALKLHLHMKKKKNDNLDEKKQAFHNLTHTYNTLREEYNALLGERSRDHNPNN</sequence>
</entry>
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    <accession>A0A0D2QUD1</accession>
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            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Wang Z."/>
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                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </evidence>
    <sequence length="675" mass="78696" checksum="2199C787D63FCF5C" modified="2015-04-29" version="1">MFPFLRRTNSSASFVSNQSQESDQTSNNTVNEQEEHYENIPQRFDNWTLPRVPTNQVYKKTTVENLNAFCSYVIKTKEMSLPIQKEYETIQLLDKVVINKLKEQRYKYIHFGLVQVGVKPLSVEPTKNTSILVVLRDQRHIMFNDSLLGTIETSLCTGSIHFNCYPNFMVSLIDKNILQSLTLQIHTHNYKMLPGTEVLTLAYRLHFKAMYSVVNTKALFQSPKGETLLIETCTTRSHTTIPRTIQWHEINFLDKWKLEGATDPVAPTPIRNTSLSEISQHQDGTVELKFNRPQRMPPRHSFKIGSTSTAFRRLNIEEESNPETQTEESPQNSPNMSLTYSSMTNNARQRENSEIFVLEKLFEINKEWCRKHFYSNKNKQKREDYFKNYNDKKESILQEYYGFMNTHKNIGIKANPLRMRAPDAEQISSKDIKMIVEQNNYTNINLHTIGKQLDYIETLVESQPIKKEPVKEIIEKSSKEPIFTPYEIPKAFQKSQNDFLTEIQNRLNALENYKSRLIAPNTPIQTQYSVNTLHQSSQSDSDQSDEQQINKMAWKEPKRLYYPKITAPDLNIEEKPVFQNKYNANTIYEWNIDEISEYNILSLLQQMTMVSNVYKTQNQNGLINDHAIANLLVVGFTGQLKGWWDHALTKTQQEEILKAIKKDDQDRIILDEQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QVK2</accession>
    <name>A0A0D2QVK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4283 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G189100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB43223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QVK2"/>
    <dbReference type="STRING" id="29730.A0A0D2QVK2"/>
    <dbReference type="Gramene" id="KJB43223">
        <property type="protein sequence ID" value="KJB43223"/>
        <property type="gene ID" value="B456_007G189100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1075">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WARIPYL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040256">
        <property type="entry name" value="At4g02000-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025558">
        <property type="entry name" value="DUF4283"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286:SF99">
        <property type="entry name" value="DUF4283 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31286">
        <property type="entry name" value="GLYCINE-RICH CELL WALL STRUCTURAL PROTEIN 1.8-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14111">
        <property type="entry name" value="DUF4283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4283" evidence="1">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="254" mass="29066" checksum="AEA1B7E35961FB28" modified="2015-04-29" version="1">MIPVGIESNTYNEQYVKRATTTLDEFSLEEQDHLERSTKKIRAVDVVESLSPAPPSQSYKESLLKPLVSNDLFQGACSVKDDDDDSDSDMEELSDEFASISVVELLEKLISYKTLTQWLTSMWNLDEEFDCIDLGHGFYVVKISSVDDGLKVITTGTWKIMDHYLTIQKWKSNCHPAIRMIVSTVVWTQLPSLPLEYFNEEVLVKGKFARICVEIDLCKPLIPSIRIGNFIQNIEYKGLHDFFSYGCFEHRTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QW58</accession>
    <name>A0A0D2QW58_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G104900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QW58"/>
    <dbReference type="Gramene" id="KJB21386">
        <property type="protein sequence ID" value="KJB21386"/>
        <property type="gene ID" value="B456_004G104900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RY21">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MANDMCI"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002262151" evidence="2">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB21386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="131" mass="11622" checksum="45BE9BD00EA4EF5B" modified="2015-04-29" version="1">MSSFRFTALMIALLVTMSAVVSESRVARKDLGLDLGGIGLGVGAGIGLGLGGGSGSGSGAGAGSGSGSGGSSSSSSSSSASSSSSSGGSGAGSYAGSRAGSGAGSEAGSSAGSYAGSRAGSGRGRGRGNGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXK6</accession>
    <name>A0A0D2QXK6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NusB/RsmB/TIM44 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G020300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXK6"/>
    <dbReference type="STRING" id="29730.A0A0D2QXK6"/>
    <dbReference type="Gramene" id="KJB21866">
        <property type="protein sequence ID" value="KJB21866"/>
        <property type="gene ID" value="B456_004G020300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790127"/>
    <dbReference type="eggNOG" id="ENOG502QS7J">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VAPPNWK"/>
    <dbReference type="OrthoDB" id="1897242at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078:SF3">
        <property type="entry name" value="ANTITERMINATION NUSB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="N UTILIZATION SUBSTANCE PROTEIN B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="NusB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NusB/RsmB/TIM44" evidence="6">
        <location>
            <begin position="185"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB21866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="292" mass="32494" checksum="77DD72923BD243DB" modified="2015-04-29" version="1">MEGIRSSSVLSCYYSSKTHFKLRRQPLEHCFLSLPPPPPPPRHPASRPKVRISLPSMALQVQDHQSFHKSKEMLPKIDKSGRFCSPRAARELALLIVYASCLQGSDPIRLFEKRINAAREPGYEFDKASLLQYNHMSFGGPPVTTHSVEEADELLRSDEQDSAIEAEVLSAPPKLVYSKLLLSFTRKLLVATVDKWDNHVLAIDKVVPSNWKNEPAGRILELSILHLAMSEITVLGTRHPIVINEAVDLANRFCDGAAPRIINGCLRTFVKDLAGTSTAQTSNSKLEVPLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QZP5</accession>
    <name>A0A0D2QZP5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CREG-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G262600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QZP5"/>
    <dbReference type="STRING" id="29730.A0A0D2QZP5"/>
    <dbReference type="Gramene" id="KJB44633">
        <property type="protein sequence ID" value="KJB44633"/>
        <property type="gene ID" value="B456_007G262600"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QV7B">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042167">
        <property type="term" value="P:heme catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033014">
        <property type="term" value="P:tetrapyrrole biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="EnsemblPlants"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.10">
        <property type="entry name" value="PNP-oxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037119">
        <property type="entry name" value="Haem_oxidase_HugZ-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343">
        <property type="entry name" value="CREG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13343:SF24">
        <property type="entry name" value="OS07G0573800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CREG-like beta-barrel" evidence="1">
        <location>
            <begin position="90"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB44633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="341" mass="38185" checksum="CA9939166463C601" modified="2015-04-29" version="1">MRTLPTTFTLSLVSRLNVYKTPPSSPMFHFCHSRFFSIPPPRPLSIMASATQPSSSQAVSPEDVNKETNIFQLIQAHQEKAARLSPVEEIRTVLDQSTRGMLSTFSQKHEGYPSASMVDFACDANGSPILAVSSLAVHTKDLLANFKCSLLVARDPEDRTDLVITLHGDAIAVSEKDQAAIRTAYLAKHPNAFWVDFADFQFMRIEPKVVRYVSGVATALLGSGEFSREEYQDSKVDPIAQFSKPVASHMNRDHAEDTKVIVQFATSIPTMLTCWIWIVLDSMSRLVIKGILSSFEFLFLDVQKIERYCVTVSSNFSRIWTNIYFQNSSNKNTITEDKQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R2C8</accession>
    <name>A0A0D2R2C8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_004G225800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R2C8"/>
    <dbReference type="STRING" id="29730.A0A0D2R2C8"/>
    <dbReference type="Gramene" id="KJB26099">
        <property type="protein sequence ID" value="KJB26099"/>
        <property type="gene ID" value="B456_004G225800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DYIDMRS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046956">
        <property type="entry name" value="RLP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063">
        <property type="entry name" value="LRR RECEPTOR-LIKE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48063:SF101">
        <property type="entry name" value="LRR RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE FLS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="12">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB26099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="906" mass="100915" checksum="9897DAC70ACD66D7" modified="2015-04-29" version="1" fragment="single">VLIEYNFPRSVRCIAAERRALLDFKKGLTVVANHLVSWTSEEEECCNWIGVGCDNSTGHVVKLDLYWMFTTGEIGYSLLELKHLSHLDLSFNSFHKIPDFIGSLSELTYLDLSYNPLTGIIPHQLGNLSRLLYLDLVPDLFYLHSLKSDNLEWLSHLSSLKSLKIGSTNFTKATNWLQVIQSHPSLSLLHFDLCDFPEVDPSSLSHFNSSNSLSVLHLTSSTLQPSTFPLLLNLSQKFVELDFSDDYLSSSISLSFDNMPALQRINLRGNNLEGGIPKFLGNICNLKELDLRDNKLSGSLGVVVKNLGCAKDSLEALALAGNRLTGALPDLSILSSLRKLSLSGNQLEGPLPVNIGKMSQLELLDVSSNSLHGVFCEVHLFNLTKLKELSISFNSLSFNLSSDWIPPFHLDYIDMRSCKLGPQFPSWLRWQTNFSVMDISDNNISGNMPNWFWNLPSGLMFLNLSFNKISGSIPNLQLEFDDSPFIVLRSNLFHGSIPPFLFNSGVLDLSINMFSGPLSLLCMRMNNGLSYLDLSYNLLVGGIPDCWNKYKSLTAINLENNNLLGVIPNSLGSLQNLKSLRLRNTSLYGEIPHSLKNCTALQLLDLGDNKLTGIIPPWIGERLDRLIVLRLRSNEFHGNIPSTLCRQQFLQVLDLSLNNISGDIPSCLNYLTAMAHFGSSMETISIMGIGYAMDFSGGIGEDFDEHLLVVWKGFEREYGNTLGLLKSIDLSCNKLSGEIPRELASLQGLINLNLSRNMLRGSIIREIGQLKSLDSLDLSTNNLSGEIPESMSELSFLSVLDLSNNKLSGKIPSSTQLQSFNAISYSGNLRLCGEPLRKCPEDEPPKVPNNGGIERSSEGDEGLFEPLWFFIGMTTGFLLVNKLREWIRLRMALMVVKLQRKLGLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5L9</accession>
    <name>A0A0D2R5L9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_002G137500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM135 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB14685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5L9"/>
    <dbReference type="STRING" id="29730.A0A0D2R5L9"/>
    <dbReference type="Gramene" id="KJB14685">
        <property type="protein sequence ID" value="KJB14685"/>
        <property type="gene ID" value="B456_002G137500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ANDDWLH"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000102">
        <property type="entry name" value="Putative serine esterase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022122">
        <property type="entry name" value="DUF3657"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12394">
        <property type="entry name" value="DUF3657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="524"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB14685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="803" mass="90943" checksum="9D6C199A82521CA5" modified="2015-04-29" version="1">MLRRIAWLIGFNNKVEQAKKLSDAKPQPAKVQPAVMLDTIQEIAIYIHRFHNLDLFQQGWYRLKITMRWENDQQTSIGAPSRVMQYEAPNVGSDDVYGVWRIDDTDNSFATRPFRIKYAKQDVLLSILVAFHLPLTENEGPLSSAVILKFELLYSPVLEKGSEFQPSSDGCPAAVHEFRIPPKALLGLHSYCPVYFDSFHAVLVDVSVHVCLLKVGSRKGAKKVPSVPYSAPNAVAGETIDGSSQALDKVACTDLKHATLVKALFDARDTLLVELQRIGNGIDQVIDLTEFTSTMNETKLSDSILQANPVTAHAEVSGQGKPQNGLEGVGGRLDVRLLQNLSKDDKIKLFNLWGEQVSYLWNTFLNFHRENKTQIVQFLRDAWSKDRRAEWSIWMVYSKVEMPHHYINGGFDEPSHHIVHKRGPSLLKLTDEPAELATMRAELHRRSIAQMRINNRSIQDMQIFADPSGVPIVIMERVINAPRRTVSDISFLKNFDVMHLATTSTVLEAGKSQSSTSAAQSGQDLKIVVFVHGFQGHHLDLRLVRNQWLLIDSKIHFLMSEANEEKTSGDFRDMGLRLAHEVIAYVKKKMDKASRSGDLRNIKLSFVGHSIGNIIIRAALAESTMEPYLRFLHTYVSLSGPHLGYLYSSNSLFKSGLWLLKKLKGTQCIHQLTFTDDPDIRNTFFYKLCKQKTLENFKNIVLLSSPQDGYVPYHSARIESCRAASTDYSKKGKAFLEMLNYCIDQIRAPTCENRVFIRCDVNFDTSTYGKNLNTLIGRAAHIEFLESDIFARFIMWSFPELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R6D4</accession>
    <name>A0A0D2R6D4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G208600</name>
        <name evidence="4" type="ORF">Gorai_017199</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB27444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000005">
        <property type="protein sequence ID" value="MBA0586457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="29730.A0A0D2R6D4"/>
    <dbReference type="Gramene" id="KJB27444">
        <property type="protein sequence ID" value="KJB27444"/>
        <property type="gene ID" value="B456_005G208600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794943"/>
    <dbReference type="eggNOG" id="KOG1080">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="PHISYVH"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10531">
        <property type="entry name" value="SET_SETD2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045606">
        <property type="entry name" value="ATXR3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057851">
        <property type="entry name" value="ATXR3_GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46655">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ATXR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46655:SF1">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ATXR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25531">
        <property type="entry name" value="GYF_ATXR3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19633">
        <property type="entry name" value="SDG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="1907"/>
            <end position="2050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1686"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1711"/>
            <end position="1724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB27444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0586457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="2479" mass="282091" checksum="25B294B278D89B75" modified="2015-04-29" version="1">MGDGVACMPLQQHQHQHQHIMERFPVTEKTLCPNNELTTKPVNLKDNAQQQQQQQPQEQQQQEQQQQQPQPQLPRKKKKLVKVKKVVVVKKKVVVGAAAAAAAAAAAATSQKSELVVKAKTEAGLKSSKEIDKGDNSGQKEEVEEGELGTLKWPREGENGEVGTDKSKNGEIEKGEITSEKCRKGEVVKEEIVREVKGELEKEETVSKKKGEVMNGEIVTGKWRKGEVAKGEMVLEKGRKAEPEKGEFGSWRGAKDDLEKGEFIPDRWHKGDLMKDEYSYSKYRKYELGKEKSWKYEMERTPPSGKYSVDDLYHRKEFSRSTLHGRSSSRWETSQDRTSRISSKIVDEEGLYKSEYSNGKNHGREYPSSGNRPKRHGTDSDSGDRKHYGDYGDYANSKCRRLSDDFGRNSHPELYSRHSVERFYKNSSSSRISSLEKYTSRHHESSLSSRVVYDKCGRSPAYSERSPRDRVRNYDHRDRSPIRRERSPWDRSPYTCEKSPYARDRSVYSRERSPYDRSRHHDHRIRSPINAGRSPEDRPRFHDRRDRTPSYLERSPHDRSKTKNQRDTSKKGAINEKRGSQYGSKGQEDKVSRRDHSGRDSHSSAKESQDRISVHNLNGSDEKNGVCESHKEDQSPTPSVNCQEPPLLVDGAPPEELQSMEEDMDICDTPPHIPLVAESAVGKWIYLDVFGIERGPSKLCDLKELVEEGVLLSDHLIKHLDSDRWVTVENAASPLLTASFPSIVSDSVTQLVSPPEAPGNLLIETGDLKPLGTHSGDETMSFQDDSAATSDSLEDLHIDERVGALLDGINIIPGKELEIVGEALQMTFDDAEWEVWGSSDGFPWLLSRTGDWHDKVTEELSSYSDTNAKEAAEPRAVAISDCSSCADSSDWFSGRWSCKGGDWKRNEEATQDRSSRKKLVLNDGYPLCLMPKSGYEDPRWHMKDDLYYPSHSKRLDLPPWAFSIAEERNDCNDISRSNQIKPSAVRGVKGTMLPVVRINACVVQDQGSFVSAPRTKTRVKERHSSRSSRSHSTTSDVKKSSAESDSLSKAVNDQRLKGSWKFAPINTPKDHVCTIDELQLHLGEWYYLDGAGHERGPSSFSELQFLVDQGVIPKYSSAFRKYDQMWVPVTSAAGSLEVTAWNRPGNVASSADSSGTTLLDSQGVAVSDNNTSSSSFHRLHPQFIGYTCGKLHKLVMKSFKSREFAAAINEVLDPWISAKQPKKEMDKHIYQKTDSGKRARMMINGSEEEYDIEDELQSIRKDDFAFEDLCGDVTFHEQESACSVTEMGNWGLLDGHVLARVFHFLRSDMKSLVFASLTCKHWRAAVRFYKGIARQVDLSSLGPNCSDSIAQKILNCYNKERINSMVLIGCTNISSITLEDVLQVFPSLSYIDIRGCSQFGELIVKFPNLRWFKSTSLHAMTISDESNSKIRTLKQITEKTSSGLKTGLGNAIDDFGELKSYFESVDRRDSANQLFRQSLYRRSKLFDARKSSSILSREARIRRWAIKKSENGYKRMEEFLASSLRDIMKENTSDFFVPKVAEIEEKMKNGYYIGHGLGYVKEDISRMCRDAIKTKNRGGARDMNRIITLFIQLATRLEEGAKITSSYERDELLKSWKDDSPTGFSKYKKKLGKAVTERKYMNKSNGTSFANGAFDYGEYASDREIRKRLSKLNRKSLDSESETSDELDRSSEDGKSESEIESTASDTESELDFKPEGRSGESRGDGYFMAGDSFDSMADDREWGARMTKASLVPPVTRKYEVIDQYVVVADEEDVRRKMQVSLPEDYAEKLNAQKTGTEELDMELPEVKDYKPRKELGDEVIEQEVYGIDPYTHNLLLDSMPEELEWPLEDKQSFIEDVLLRTLNKQVRQFTGTGNTPMMYPLKPIVEEIKRVAEVDCDKRTMKMCQGILKAIDDRPDDNYVAYRKGLGVLCNKEGGFREEDFVVEFLGEVYPVWKWFEKQDGIRLLQNNSKDPAPEFYNIYLERPKGDAGGYDLVVVDAMHKANYASRICHSCHPNCEAKVTAVDGQYQIGIYALRAIRYGEEITFDYNSVTESKEEYEASVCLCGSQVCRGSYLNLTGEGAFQKVLKEWHGILDRQQLMLEACELNSVSEEDYLELGRAGLGSCLLGGLPDWLVAYSARVVRFINFERTKLPEQILRHNLEEKRKYCIDISLDAERNDAEIQAEGVYNQRLQNLAITLDKVRYVMRCVFGDPKKAPPPIERLSPEEAVSFLWKGEGSLVEELLQSMAPHVEDETLNDLRSKIQVHDPSWSDNILKELQKSLLWLRDEVRNLPCTYKCRHDAAADLIHIYAYTKCFIRVREYKAVTSPPVYISPLDLSPKYSDKFTGLQEYCKTYGENYCLGQLVFWYNQTSVDPDSSLFRASRGCLSLPDIGCFYAKVQKPSRHRVYGPKTVKFMLSWMEKQPQRPWPKDRIWTFKGSPRIFGSPMLDAVLNNSSLDREMVQWLKHRPAKFQAMWDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9Y8</accession>
    <name>A0A0D2R9Y8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_004G241700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin U/P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9Y8"/>
    <dbReference type="STRING" id="29730.A0A0D2R9Y8"/>
    <dbReference type="Gramene" id="KJB26441">
        <property type="protein sequence ID" value="KJB26441"/>
        <property type="gene ID" value="B456_004G241700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792530"/>
    <dbReference type="eggNOG" id="KOG1674">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MFHASEV"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF124">
        <property type="entry name" value="CYCLIN-P3-1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB26441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="220" mass="24977" checksum="6CC93323CDE451AC" modified="2015-04-29" version="1">METLMAKGKAGESNPYTGLGLDESGNWLPGSPRVLSLLSSVLERSVRGNEKLLAGSKIKDVITIFHGSRAPSLNLRQYVERIFKYCKCSNSCFVVAVIYIDRFLQRIDAYLTSLSVHRLLITSVMVAAKFMDDQHYNNAYYAKVGGISREEMNRLEMRFLFDLDFQLNVTTEVFNKYWLMIQQEGGLETQTALQTQGYCLKKDETGRGRRLTGVHRGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RAI8</accession>
    <name>A0A0D2RAI8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_004G252500</name>
        <name evidence="13" type="ORF">Gorai_015539</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCTP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0584741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RAI8"/>
    <dbReference type="STRING" id="29730.A0A0D2RAI8"/>
    <dbReference type="Gramene" id="KJB26641">
        <property type="protein sequence ID" value="KJB26641"/>
        <property type="gene ID" value="B456_004G252500"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYX">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IRTWAHP"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04022">
        <property type="entry name" value="C2A_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08379">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000090">
        <property type="entry name" value="C2 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047255">
        <property type="entry name" value="C2D_MCTP_PRT_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013583">
        <property type="entry name" value="MCTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047259">
        <property type="entry name" value="QUIRKY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425:SF43">
        <property type="entry name" value="MULTIPLE C2 DOMAIN AND TRANSMEMBRANE REGION PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31425">
        <property type="entry name" value="PHOSPHORIBOSYLANTHRANILATE TRANSFERASE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08372">
        <property type="entry name" value="PRT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="831"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="946"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="574"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="138"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB26641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0584741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112780" checksum="A3274ED1ABEF0DC8" modified="2015-04-29" version="1">MAENCTRKLIVEICNAKNLMPKDGQGTASAYAIVDFDGQRRRTKTKFRDLNPVWDEKLEFLVHDIESMAAEMLEINLYNDKKMGKRSTFLGKVKLAGSVFVKAGEETLVYYPLEKRSVFSQIKGEIGVKVFYVDEEAPPAPAEPAAEQKAETAEEKPKEEEDKKEENVEEKKEEEEKPKEEPPKEEEKPNPPPVEASKSEDTTAAATPPPPPPEVENPPIAHKEEASSTKVVATKSKAETGKSSQLVINELELRSLSGDHNRIAYDLVDRMPFLYVRVVKAKRANKEPACPLHAKLVIGTHSIKTKSQIDKDWDQVFAFDKEGLNSSSLEVSVWAEEEKKEEQKEGDAAATASTVVVDNCLGAVSFDLQEVPKRVPPDSPLAPQWYSLESEKSPGNDVMVSVWVGTQADEAFQEAWQSDSGGLIPETRAKVYLSPKLWYLRLTVIQTQDLQLGSGSESKVRSPELYVKAQLGAQLFKTSRTPVGLAWNEDLVFVAAEPFEPFLVVMVEDWSNGQLVGQAKIHVPSLERRTDDKTEPKSRWFNLVGAENKPYAGRIHVRACLEGGYHVLDEAAHVTSDVQAAAKQLAKPLIGLLDVGIRGASNLLPVKTKDGTRGTTDAYVVAKYGQKWIRTRTILDRFNPRWNEQYTWDVYDPCTVLTIGVFDNGRYKRDEAGKPGRDLRIGKIRVRLSTLDTNKVYLNSYMLTVLLPNGAKKMGEIEIAVRFSCSSWLSLIQAYGTPLLPRMHYLRPLGPAQQDILRQTAMRIVTARLARSEPPLGQEVVQFMLDTDTHVWSMRKSKANWFRVVGCLSHAAILARWLDGIRTWAHPPTTILVHVLLIAVVMCPQLVLSTIFMYAFLILALRFRYRMRVTHNVDLRLSYVDAVGPDELDEEFDGLPTTRSPDTVRFRYDRLRALASRAQTLLGDVAAQGERLEALFNWKDPRATGIFVVVCLFASLLFYVVPFKVFVLGSGFYYIRHPRFRGDMPSAPLNFFRRLPSLSDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RBG4</accession>
    <name>A0A0D2RBG4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Homeobox-leucine zipper protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HD-ZIP protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Homeodomain transcription factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_008G075100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the HD-ZIP homeobox family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RBG4"/>
    <dbReference type="Gramene" id="KJB48568">
        <property type="protein sequence ID" value="KJB48568"/>
        <property type="gene ID" value="B456_008G075100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0483">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TEIYVEM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000232">
        <property type="entry name" value="homeobox-leucine zipper protein ATHB-13-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045224">
        <property type="entry name" value="HDZip_class_I_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000047">
        <property type="entry name" value="HTH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24326:SF535">
        <property type="entry name" value="HOMEOBOX-LEUCINE ZIPPER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00031">
        <property type="entry name" value="HTHREPRESSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0371">Homeobox</keyword>
    <keyword evidence="6 8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Homeobox" evidence="12">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="8">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB48568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="98" mass="11570" checksum="022E45B688AA57E8" modified="2015-04-29" version="1">MLDGLDEEDSLEEGGQATEKKRRLSMHQVKALEKNFDVGNKLEPERKVKLAEELGLQPRQVAIWFQNRRARWKTKVLEKDYAMLKANREKEPLWKSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RDY5</accession>
    <name>A0A0D2RDY5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_008G119500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPR family. P subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB49433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RDY5"/>
    <dbReference type="Gramene" id="KJB49433">
        <property type="protein sequence ID" value="KJB49433"/>
        <property type="gene ID" value="B456_008G119500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105763850"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IHAYCLN"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932">
        <property type="entry name" value="ATPASE EXPRESSION PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47932:SF13">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ML104 (RPPR9)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12854">
        <property type="entry name" value="PPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="329"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="370"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="406"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="477"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="512"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="547"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="582"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="617"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="653"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="3">
        <location>
            <begin position="688"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB49433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="84180" checksum="5ED437DBD3FCA18E" modified="2015-04-29" version="1">MNTTLTVSKHSKLLRPYLLKHNRRFCTEPNPQPLTPPQDDEQRITQTVQHLLETPHQEWSSSQPLQSLLFSSPLPSPRSILKTTRSLPSYCQALNFFQHLRENSLSTNTQSLSHSLQALLELAGREPDAASRLFELYQASKEWSVPLTVNAAALLIRYFGRLEMVDKSIVVFDEIDLSIKNTHIRNILIDVLLRDGRVDRALNVLDEMLQPVSQSPPNDVTGDIVFYGLTKRGRKGRNVSEEELIKLVLNLGKHSVFPRTNWLTQLVSSLCRNGKINQAWDVLHEQLKLGAPIESPTFNVLLTGLVRCGDVKRMNTALAEMKESGVQPDVVTLGIVINQLCKLRRVDDAMEVFNKMGEETGIDGVSVEADIVILNTLINGLCKVGRQEEGLDLMEKTKSNKGLVPNTVTYNCLIDGFCKVGEVEKGKELFEKMQQDGVSPNAITVNTLVDGMCRHRRINSALEFFGDMKEKGVKGNAAAAYTTLITAFCNADNFCKAVDLFDEMVRSGCSADAIVYYSLISGLCRAGRMDDAGNVYSKMKVAGFHPDIVCYNSLISGFCKKKKVDQAYEIVKEMEETGVKPDTITFNTLIAHFCKAGNFTLAHRVMKKMVKEGLAPTVATYGALIHGYCINGKLDDARKIFNNMSSTSKVPPNTVVYNILIESLCKNNDVKAALSLMDEMKAKGVKPNTTTYNAVFKGLKENNLLEDAFILMDSMIEHGCSPDYITMEILTQWLSTVGESDKLKSFVQGHKVSTLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RF39</accession>
    <name>A0A0D2RF39_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_003G170600</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Autophagosome membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the ATG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RF39"/>
    <dbReference type="STRING" id="29730.A0A0D2RF39"/>
    <dbReference type="Gramene" id="KJB17790">
        <property type="protein sequence ID" value="KJB17790"/>
        <property type="gene ID" value="B456_003G170600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB17791">
        <property type="protein sequence ID" value="KJB17791"/>
        <property type="gene ID" value="B456_003G170600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105789244"/>
    <dbReference type="eggNOG" id="KOG1654">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TYCGENT"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000421">
        <property type="term" value="C:autophagosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16128">
        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000010">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0072">Autophagy</keyword>
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    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12 15" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="15">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB17790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="122" mass="14013" checksum="3264F7E73CAAD59F" modified="2015-04-29" version="1">MAKSYFKQEHDLEKRRAEAARIREKYPDRIPVIVEKAEGSDIPNIDKKKYLVPADLTVGQFVYVIRKRIKLSAEKAIFMFVENVLPPTGAIMSAIYEEKKDEDGFLYVTYCGENTFGDLSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGG0</accession>
    <name>A0A0D2RGG0_GOSRA</name>
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        <recommendedName>
            <fullName evidence="10">HSF-type DNA-binding domain-containing protein</fullName>
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        <name evidence="11" type="ORF">B456_011G036400</name>
        <name evidence="12" type="ORF">Gorai_005283</name>
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    <organism evidence="11 13">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="12 14" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="12" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">8</strain>
            <tissue evidence="12">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the HSF family. Class A subfamily.</text>
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        <property type="protein sequence ID" value="KJB69672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB69673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB69674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB69675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0599044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB69672"/>
        <property type="gene ID" value="B456_011G036400"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB69673"/>
        <property type="gene ID" value="B456_011G036400"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB69674"/>
        <property type="gene ID" value="B456_011G036400"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB69675"/>
        <property type="gene ID" value="B456_011G036400"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
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    <dbReference type="OrthoDB" id="60033at2759"/>
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        <property type="component" value="Chromosome 11"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Heat shock transcription factor 1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015">
        <property type="entry name" value="HEAT SHOCK TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10015:SF161">
        <property type="entry name" value="HEAT STRESS TRANSCRIPTION FACTOR A-4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HSFDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00415">
        <property type="entry name" value="HSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00434">
        <property type="entry name" value="HSF_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="348"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB69672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="MBA0599044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="403" mass="45923" checksum="D5D6CEEDB546019C" modified="2015-04-29" version="1">MDDAQGSSSSLPPFLAKTYEMVDDPSTDSIVSWSASDKSFVVWNPPEFARDLLPRFFKHNNFSSFIRQLNTYGFRKIDPEQWEFANDDFVRGQPHLLKNIHRRKPVHSHSMQSHLGQGASSLTESERQNLRDEIERLKNEKELLALELKRHEQERQGFQLQMRLLRERLQNMERRQQIMMSSVARVLQKPGVAINLTPQLETNDRKRRLTRIAYLYDEAGIEDSQTGNSLISRENVDSTSLSNMEPFEQLESSMVFWENAVHDFGQTNIQHESNLELDESTSCAETPATSCIQLNIDARLKSPGIDMNSEPALVVVSEPITAKEQAAGTTAPATTGVNDIFWEQFLTENPGSTDTQEVQSERKDSDASKNESKPGDHGKFWWNTKNVNNLAEQMGHLTPAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKD2</accession>
    <name>A0A0D2RKD2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PRKR-interacting protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_005G235000</name>
        <name evidence="3" type="ORF">Gorai_017372</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
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    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="MBA0586638.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
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    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
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    </evidence>
    <sequence length="172" mass="19753" checksum="1369E41FBF2920B9" modified="2015-04-29" version="1">MSTGRPKDGDTQLAVVEPKSGLPPRPPSTTSTAIVEYEKPAFKEEEEDLEVKLRRIIENVPVRVSNTSGSSAGSGSGDFHQYRQMRRKEQDRLARMDVDYQKRKEIAEFNMRREERLKAAEERTAKKRLKRQKKKQRKKEKKMKSSAEGGENKKEESSDDEADSEHDEATVE</sequence>
</entry>
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        <name type="scientific">Gossypium raimondii</name>
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    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
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                <person name="Reddy U.K."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="entry name" value="UBC"/>
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        <property type="entry name" value="UBQ-conjugating_AS"/>
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        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
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        </location>
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        <location>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB34474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB34474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="12" mass="1530" checksum="DAE6C989692EA2D2" modified="2015-04-29" version="1" fragment="single">FRFWVVCLSIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RRM3</accession>
    <name>A0A0D2RRM3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase catalytic subunit</fullName>
            <ecNumber evidence="4">2.8.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2 large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdenum cofactor synthesis protein 2B</fullName>
            <shortName evidence="4">MOCS2B</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G013600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + cyclic pyranopterin phosphate + H2O = molybdopterin + 2 [molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26333"/>
            <dbReference type="Rhea" id="RHEA-COMP:12202"/>
            <dbReference type="Rhea" id="RHEA-COMP:19907"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58698"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="ChEBI" id="CHEBI:232372"/>
            <dbReference type="EC" id="2.8.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MoaE family. MOCS2B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.12" evidence="4"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB21786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RRM3"/>
    <dbReference type="SMR" id="A0A0D2RRM3"/>
    <dbReference type="STRING" id="29730.A0A0D2RRM3"/>
    <dbReference type="Gramene" id="KJB21785">
        <property type="protein sequence ID" value="KJB21785"/>
        <property type="gene ID" value="B456_004G013600"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB21786">
        <property type="protein sequence ID" value="KJB21786"/>
        <property type="gene ID" value="B456_004G013600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790059"/>
    <dbReference type="eggNOG" id="KOG3307">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WKHQFFA"/>
    <dbReference type="OrthoDB" id="5531344at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.40:FF:000002">
        <property type="entry name" value="Molybdopterin synthase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="entry name" value="Molybdopterin biosynthesis MoaE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03052">
        <property type="entry name" value="MOC2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028888">
        <property type="entry name" value="MOCS2B_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23404">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="Molybdopterin synthase subunit MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB21785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="186" mass="20650" checksum="6B8D19456DD59127" modified="2015-04-29" version="1">MNSEEKTLVEIIDDNNQINLAKYINYVSAPQAGAIATFSGTTRDTFEGKTVVELRYEAYVPMAIKNLKSICSAARSSWDLHSIAVAHRLGIVPVGETSVFVAVSATHRADSLDACKFLIDELKASVPIWKKEVYSDGEVWKENPEFLERRLELGKDGGCCRRKIETAAHDKKSCCKPKVKVEEAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RS27</accession>
    <name>A0A0D2RS27_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAR-binding filament-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_005G234100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RS27"/>
    <dbReference type="STRING" id="29730.A0A0D2RS27"/>
    <dbReference type="Gramene" id="KJB32296">
        <property type="protein sequence ID" value="KJB32296"/>
        <property type="gene ID" value="B456_005G234100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795207"/>
    <dbReference type="eggNOG" id="ENOG502QR79">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="EENDHCE"/>
    <dbReference type="OrthoDB" id="4115at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008479">
        <property type="entry name" value="DUF760"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598:SF2">
        <property type="entry name" value="MAR-BINDING FILAMENT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33598">
        <property type="entry name" value="OS02G0833400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05542">
        <property type="entry name" value="DUF760"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="44201" checksum="09D7CD88D9927E3E" modified="2015-04-29" version="1">MIIMATTPLSSHFSPLPSFSSSQSRSVPKPLLFPSSFPSSNFRKLRKTPLLVLSSNNFDAFPSRDASGSNPISSKKSVLNVLIQDIEPLDVSLIHKDVPPTTVDAMKRTISGMFGLLPSDRFQVYIEAMWEPLSKLLVSSMMTGYTLRNAEYRLCLERNLGCDTDLEHQSSEKPNFDLQEIVLDGTKVKELSRKNDSSSESEKTTENQFEDIEFEGLGEISPETRKYILHLQSRLASVKKELHELKKKNEAMQMQQFVGEEKNDLLDYLRSLQPEKVVELSEPSSPELKETIHSVVHGLLATLSPRMHSKVPLSENTATGTVNIGSENCSELVEDTSLQLQPLISLTRDYLARLLFWCMLLGHYLRGLEYRQELMELLSLTSSVNNNDCGGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSE1</accession>
    <name>A0A0D2RSE1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_011G246800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSE1"/>
    <dbReference type="Gramene" id="KJB73637">
        <property type="protein sequence ID" value="KJB73637"/>
        <property type="gene ID" value="B456_011G246800"/>
    </dbReference>
    <dbReference type="OMA" id="FGHENDS"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002250423" evidence="1">
        <location>
            <begin position="23"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB73637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="139" mass="16451" checksum="EDBDF8998898292B" modified="2015-04-29" version="1">MAPVWFFFQGLLLLKASPTVMSLEICFELKMVIIYISLNEEANKDFRKPFSLHKFGHENDSFGKKYFNEGEIHCVEFKGYSPKTIFMVYLKLKSYSAILNQEKRSFLQFIRKSTICWLLNQYTPTLHYNLPCTVMRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RT22</accession>
    <name>A0A0D2RT22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_011G2584001</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RT22"/>
    <dbReference type="STRING" id="29730.A0A0D2RT22"/>
    <dbReference type="Gramene" id="KJB73882">
        <property type="protein sequence ID" value="KJB73882"/>
        <property type="gene ID" value="B456_011G2584001"/>
    </dbReference>
    <dbReference type="OMA" id="YERATNC"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051564">
        <property type="entry name" value="LRR_receptor-like_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055:SF55">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB73882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="217" mass="23901" checksum="BA88A4F06A175467" modified="2015-04-29" version="1" fragment="single">VAHALEYLHHRCETPIIHCDLKPSNILLDEEMVGHISDFGIAKILSGDELNYSANESSSLGLRGTIGYAPPEYGMGSELSTNGDVYSYGILLLEMLTGKRPTNERFKEGLSLHNFVKAALPNRVVEIIDPILLQESVRGGTVADITLNENNLGNDKYLQCLNSIFKIGLTCSAESPSERMDMSDVVTKLCSIRDKLLCPTRLYRGIRTAYDAKPIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RT35</accession>
    <name>A0A0D2RT35_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">B456_011G259700</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RT35"/>
    <dbReference type="STRING" id="29730.A0A0D2RT35"/>
    <dbReference type="Gramene" id="KJB73897">
        <property type="protein sequence ID" value="KJB73897"/>
        <property type="gene ID" value="B456_011G259700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QPYS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000358">
        <property type="entry name" value="Putative leucine-rich repeat receptor-like serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051564">
        <property type="entry name" value="LRR_receptor-like_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR PROTEIN KINASE EMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48055:SF55">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-0675">Receptor</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="KJB73897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="307" mass="34159" checksum="DBA16AA291B40E43" modified="2015-04-29" version="1" fragment="single">VLNLLNHRASRSFLVECEALKSIRHRNLVKVLTAISGIDYQGNDFKALVYEFMENGSLEDWLHSSVGMNEPETMRNLNFIQRVNVAVDVAHALEYLHHRCETPIIHCDLKPSNILLDEEMVGHISDFGLAKILSGDELNYSANESSSLGLRGTIGYAPPEYGMGSELSTNGDVYSYGILLLEMLTGKRPTNERFKEGLSLHNFVKAALPNRVVEIIDPILLQESVRGGTVGDITLNENNLGNDKYLQCLNSIFKIGLTCSAESPSERMDMSDVVTKLCSIRDKLLRPTRLYRGIRTAYDAKPTVAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RTG0</accession>
    <name>A0A0D2RTG0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G046800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RTG0"/>
    <dbReference type="Gramene" id="KJB22420">
        <property type="protein sequence ID" value="KJB22420"/>
        <property type="gene ID" value="B456_004G046800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793076"/>
    <dbReference type="eggNOG" id="KOG0800">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNFVHEN"/>
    <dbReference type="OrthoDB" id="4348522at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF59">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SDIR1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
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                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
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                <person name="Grupp K."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
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                <person name="Tang H."/>
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                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Jin D."/>
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                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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                <person name="Duke M.V."/>
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                <person name="Grover C."/>
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                <person name="Lee T.H."/>
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                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
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                <person name="Rainville L.N."/>
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                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Peterson D.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Jin D."/>
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                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S538"/>
    <dbReference type="STRING" id="29730.A0A0D2S538"/>
    <dbReference type="Gramene" id="KJB26385">
        <property type="protein sequence ID" value="KJB26385"/>
        <property type="gene ID" value="B456_004G239300"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792502"/>
    <dbReference type="eggNOG" id="ENOG502QTR3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="498177at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053305">
        <property type="entry name" value="Folate-binding_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390:SF1">
        <property type="entry name" value="FOLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390">
        <property type="entry name" value="OS02G0592500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="5">
        <location>
            <begin position="67"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB26385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="309" mass="33775" checksum="97670BC237FCE122" modified="2015-04-29" version="1">MIHSSKIRVQVKAMNNIELGFLIFLLLFNLLLPFSYGEAGGLCVSQGGRFPPFSSEGKPPKRVGKGHKDLTLCRVFRKKTCCDAAQTHPALLSIRRLALTGEASEECLHLWELLECSICDPRVGVQPGPPLICTSFCDRVFQACSNAYFSMDAKTQVLAPCGANDFVCGRASEWASNGTELCLAAGFRVEQSVGMHGGIEELSCYGGKASLDSIADSWGASRSEKPHKTGNSGLLEDFQQWLQDMPSNERVSWAVGGLVLTAGLLFISKRKSHNQRQKLAAIQRAARRLEVKMNPTPTSSQGNRKGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S826</accession>
    <name>A0A0D2S826_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">B456_007G064900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Acts in the modification of cell walls via demethylesterification of cell wall pectin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the pectinesterase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the PMEI family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB40459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S826"/>
    <dbReference type="STRING" id="29730.A0A0D2S826"/>
    <dbReference type="Gramene" id="KJB40459">
        <property type="protein sequence ID" value="KJB40459"/>
        <property type="gene ID" value="B456_007G064900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105802322"/>
    <dbReference type="eggNOG" id="ENOG502QW0X">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FIHCTLE"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004857">
        <property type="term" value="F:enzyme inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd15798">
        <property type="entry name" value="PMEI-like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000001">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.40:FF:000021">
        <property type="entry name" value="Probable pectinesterase/pectinesterase inhibitor 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.40">
        <property type="entry name" value="Invertase/pectin methylesterase inhibitor family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035513">
        <property type="entry name" value="Invertase/methylesterase_inhib"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006501">
        <property type="entry name" value="Pectinesterase_inhib_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01614">
        <property type="entry name" value="PME_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31707">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04043">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00856">
        <property type="entry name" value="PMEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101148">
        <property type="entry name" value="Plant invertase/pectin methylesterase inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pectinesterase inhibitor" evidence="12">
        <location>
            <begin position="66"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00057335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="KJB40459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="577" mass="63340" checksum="D08E59B34F6F9355" modified="2015-04-29" version="1">MHSSSPPPSHQSHKKHPRRNPWNSTSLLVSLSMSAFLLLSLLSLSHFFIFSSSSHHPPHNSPVYASDSSRIRLACKSTRFPQPCESSLSRSSLLPPNPTSLQFIQSAISVSSDNLKTGQSMVKSILDSSKGNLNRSNAAAICLNILSNSDYRIRSTNAALARGKIKDARAWMSAALCYQYDCWSALKYVNDTKLVGETMAFLDSLTQHSSNALSMMVAYDNIGEDIAAWVPPKTERDGFYENGSGGTELGFNGGLPSNLKTDVTVCKDGRGGCYKTVQEAVNAAPAPANAESTRRFVIYIKEGVYEETVRVPLEKKNVVFLGDGMGKTIIAGALNAGMPGLTTYETATVGVLGDGFMASGLTIRNTAGPDAHQAVAFRSDSDLSVIENCEFLGNQDTLYAHSLRQFYRKCRIQGNVDFIFGNSASVFQDCEILVAPRQVKPEKGENNAVTAHGRTDPAQSTGLVFQNCLINGTDEYMRYYYSKPKVHKNFLGRPWKEYSRTVFINCVMEALINPNGWMPWKGDFALKTLFYGEFGNSGLGSIPLNRVPWSTQIPPQHVHTFSVQNFIQGDQWIPTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SE07</accession>
    <name>A0A0D2SE07_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Polyadenylate-binding protein</fullName>
            <shortName evidence="11">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_005G101600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="11">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SE07"/>
    <dbReference type="STRING" id="29730.A0A0D2SE07"/>
    <dbReference type="Gramene" id="KJB29450">
        <property type="protein sequence ID" value="KJB29450"/>
        <property type="gene ID" value="B456_005G101600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105797316"/>
    <dbReference type="eggNOG" id="KOG0123">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NMPEVAP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000217">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000239">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000285">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="30"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="118"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="209"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="13">
        <location>
            <begin position="312"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="14">
        <location>
            <begin position="549"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="637"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB29450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="648" mass="71014" checksum="2BBD880838DF020F" modified="2015-04-29" version="1">MAQVQVQHHASVSGPISVASGHGGAQFMPTSLYVGDLDVSVTDEQLYQTFGEVAPVVSVRVCRDTATGRSLGYGYVNYNNPRDAARALDLLNFTPMNNKPIRIMYSQRDPSLRKSGTANIFIKNLDKSIDHKALHDTFSSFGNILSCKISTDGLGQSKGYGFVQFDNEESAQNAIDKLNGMLINDKQVYVGHFLCKHERETAPNKVKFNNVYVKNLSDTTTDEELKTIFGEHGEITSVVVMRDADGKSKCFGFVNFENADDAAKAVEALNGKKFEDKEWYVGKAQKKSEREHELKARFEQNMKEASDKFQGLNLYIKNLDDSIGDEKLKKMFSEFGNITSCKIMRDPSGISKGSGFVAFSTPEEASRALAEMNGKMIVSKLLYVAPAQRKEERRAQLQAQFSQMRPLAIPSAAPRMPVYPSGAPGLGQQFFYGQAPPTVIPPQAGFGYQQQLVPGMRPGGPPMPNYFVPMVQQGQRPGGQRGTGRVQQAQQPVSLMQQPMLPRGQVYRYPPGHNMPEVAPSNVPGGMLSIPYDMGSMPVRDAGSGQPIPVTALATSLANATPEQQRTMLGESLYPLVERLERDAAAKVTGMLLEMDQTEVLHLLESPEALKAKVAEAMEVLRSVAAQQQSNNPADQLSSLSLNDNLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNI9</accession>
    <name>A0A0D2SNI9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G259200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SNI9"/>
    <dbReference type="SMR" id="A0A0D2SNI9"/>
    <dbReference type="STRING" id="29730.A0A0D2SNI9"/>
    <dbReference type="Gramene" id="KJB32745">
        <property type="protein sequence ID" value="KJB32745"/>
        <property type="gene ID" value="B456_005G259200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105795454"/>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FHAPAMY"/>
    <dbReference type="OrthoDB" id="935493at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048767">
        <property type="term" value="P:root hair elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Actin"/>
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        <property type="entry name" value="Actin/actin-like_CS"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
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        <property type="entry name" value="ACTINS_ACT_LIKE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
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    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="41536" checksum="7DC7F97AF34270B6" modified="2015-04-29" version="1">MADEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDSLMKILTERGYSFTTTAEREIVRDMKEKLAYVALDFEQELETAKSSSAIEKSYELPDGQVITIGAERFRCPEVLFQPSLIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGSTMFPGIADRMSKEITALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQMWISKGEYDESGPAIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SNS2</accession>
    <name>A0A0D2SNS2_GOSRA</name>
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        <recommendedName>
            <fullName evidence="8">TF-B3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_005G2642001</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001744">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="KJB32830"/>
        <property type="gene ID" value="B456_005G2642001"/>
    </dbReference>
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        <property type="component" value="Chromosome 5"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
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        <property type="entry name" value="DNA-bd_pseudobarrel_sf"/>
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        <property type="entry name" value="DNA-binding pseudobarrel domain"/>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB32830.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11561" checksum="CB7FED06C7E98BCA" modified="2015-04-29" version="1" fragment="single">KTVEEPDLLKLTVTEAYDTEPFPNAASSGSLTVIDERGLPCTFYYRVSRRGRVLSGSRWQDFIRRNGVRVGDTVSIERNDGHAYPAPYKIEIIRNPRNSSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SVN4</accession>
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            <fullName evidence="1">F-box domain-containing protein</fullName>
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        <name evidence="2" type="ORF">B456_006G111900</name>
        <name evidence="3" type="ORF">Gorai_000731</name>
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        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="3 5" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">8</strain>
            <tissue evidence="3">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001745">
        <property type="protein sequence ID" value="KJB35380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000006">
        <property type="protein sequence ID" value="MBA0587605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SVN4"/>
    <dbReference type="STRING" id="29730.A0A0D2SVN4"/>
    <dbReference type="Gramene" id="KJB35380">
        <property type="protein sequence ID" value="KJB35380"/>
        <property type="gene ID" value="B456_006G111900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105799218"/>
    <dbReference type="eggNOG" id="ENOG502QUB6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CHTLANF"/>
    <dbReference type="OrthoDB" id="1891924at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055411">
        <property type="entry name" value="LRR_FXL15/At3g58940/PEG3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639">
        <property type="entry name" value="F-BOX PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31639:SF139">
        <property type="entry name" value="F-BOX_LRR PLANT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24758">
        <property type="entry name" value="LRR_At5g56370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
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    </dbReference>
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            <end position="45"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Jones D.C."/>
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                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
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                <person name="Reddy U.K."/>
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                <person name="Scheffler J.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="17" mass="1853" checksum="50A43EE82E4221FE" modified="2015-04-29" version="1" fragment="single">ELTSESGVLRCSRSLIC</sequence>
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                <person name="Gundlach H."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
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                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
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                <person name="Hovav R."/>
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                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="gene ID" value="B456_010G231300"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="ACTIN BINDING PROTEIN FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31342">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="14"/>
            <end position="32"/>
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            <end position="83"/>
        </location>
    </feature>
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    </feature>
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            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
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    <organism evidence="3 4">
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        <lineage>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
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        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
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                <person name="Brubaker C.L."/>
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                <person name="Reddy U.K."/>
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                <person name="Peterson D.G."/>
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                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
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        <location>
            <begin position="11"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
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        </location>
    </feature>
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            <begin position="294"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB71513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="832" mass="92288" checksum="4CCE677C331AC9FE" modified="2015-04-29" version="1">MLPKAYRTSSIDWKPSPVVALATSPDGSQVAAARDDGSLEIWLVSPGSVGWHHQLTIHGDSTCRVSSLVWCCVGSKGPSPGRLFSSSIDGSVSEWDLFDLKQKILLESIGVSIWQMAVAPINRLPTHEETRSQNFGNGYLNDKYECDDTDDVENCESEDVSDSEQVYQKLVMEDRCVAIACDDGAVRMYTISDLDKLIYQKSLPRVSGRALSVTWSHDSNRIYSGSSDGLIRCWNADLGHEIFRSVVGLGGLGSGPELCVWSLLSLRCGTVVSADSTGSVQFWNGDNGTLLQTHSTHKGDVNALAASPRQNRVFSAGSDGQVILYKLSSEMLQSGNDKSYEMLKKWVFVGSARAHTHDVRALTMAVPICSEGSLSDEAKDLQDEKRKKVKRIRTREKKPLNFSYGKWAHFGVPMLVSAGDDAKLFAYSAMEFTRFSPHDICPAPQRVPIHLVTGSRFNQTSFLFVQASCWLDVLSVNAPDGGSGPYGGLVTTNIVARVKSKAGRKIICSAMSNSGEFFGYSDHIRPSLFELSRQAGQSTWTISKRQLPQKLPSAHSMIFTSDGSRLLIAGHDRRIYVVDLESLKLLHTFIPCRQEHEKEGPPDEPPITKMFTSSDDQWLAAINCFGDIYLFNLEILRQHWFISRLDGASVTAGGFPPQRNNVLIITTSSNQFYIFDVEARQLGEWSMQHSFTLPRRYQEFPGEVIGLSFCPSSSSHPSKSTSLVVYSARAMCSIDFGKAVDEDDESQLVHEALLKLQGSITNKKLKYLLIDGRQTESKHTSRKNNFEIIGFRDPVLFIGHLSKNSILMVDKPWMEVVKSFDTAPVQRHIYGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2T8M6</accession>
    <name>A0A0D2T8M6_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">B456_008G285200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB52954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_008G285200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765622"/>
    <dbReference type="eggNOG" id="ENOG502S3R7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="entry name" value="F2P16.13 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33237:SF46">
        <property type="entry name" value="OS01G0606100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB52954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="159" mass="17611" checksum="0F2CC64E1F402878" modified="2015-04-29" version="1">MDSAEHGTTSHRQRLTLGFLISFMALCAKRASRLSKKLKPKQNSLASGTPRFYEPKSPLKSPLRSPMPKQLLATISHKAITLVNRKKLGGGNGKHVEEEDYGDGGVWQRAILMGDKCQPLDFSGVIYYDNKGNQLDELPIRSPRASPLPSYLTRKGGFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TB05</accession>
    <name>A0A0D2TB05_GOSRA</name>
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        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
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        <name evidence="4" type="ORF">Gorai_010236</name>
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        <name type="scientific">Gossypium raimondii</name>
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    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2TB05"/>
    <dbReference type="Gramene" id="KJB51676">
        <property type="protein sequence ID" value="KJB51676"/>
        <property type="gene ID" value="B456_008G228100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG3249">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FLWFIMA"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039159">
        <property type="entry name" value="SAYSD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019387">
        <property type="entry name" value="SAYSvFN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13527:SF0">
        <property type="entry name" value="SAYSVFN DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10260">
        <property type="entry name" value="SAYSvFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB51676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0593283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="234" mass="26858" checksum="283C4F2D8893B1D4" modified="2015-04-29" version="1">MRMEEIVEETNGKHEKMVEITLKIIGPARPSRLHVPCSLRVHDLRKLIAGKNRLPVENLKLISQGKVLHDREDEDDIYIQLNDGDSLIVAVKPKAPSGLDIDDDEEDLKFQLPQSTSWWKKKLYSFLLNRLKLPDILLMAIFSLSLKAWILVILWFILAHVAHKWDLGPLYILGTGFCTIFLNLGRRQPGDVRYPLASKLQFLSAYSIFNEDFRELPGTLNADAIDRDIRTGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TJZ5</accession>
    <name>A0A0D2TJZ5_GOSRA</name>
    <protein>
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            <fullName evidence="9">Fibronectin type III-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_007G230000</name>
        <name evidence="11" type="ORF">Gorai_019343</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TJZ5"/>
    <dbReference type="STRING" id="29730.A0A0D2TJZ5"/>
    <dbReference type="Gramene" id="KJB44020">
        <property type="protein sequence ID" value="KJB44020"/>
        <property type="gene ID" value="B456_007G230000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804107"/>
    <dbReference type="eggNOG" id="ENOG502QQ55">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NICTIEH"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000001">
        <property type="entry name" value="probable beta-D-xylosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000004">
        <property type="entry name" value="probable beta-D-xylosidase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF1">
        <property type="entry name" value="BETA-D-XYLOSIDASE 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033715629" description="Fibronectin type III-like domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="9">
        <location>
            <begin position="714"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB44020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0590647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="791" mass="86930" checksum="C057776DD57AB3AD" modified="2015-04-29" version="1">MSLQLKSLFFILQLLALLISISSSDPNPQFPCQPPHFNSYPFCNTSLSITDRAQSLISLLTLEEKIHQLSNNASGIPRLGIPPYEWWSESLHGVASNGPGVNFNGYVKAATSFPQVLVTAASFNRTLWFKIGLAIGIEAKAMYNVGQAGLTFWAPNINIFRDPRWGRGQETPGEDPMVVSAYAIQFVKGFQGGSWRGSGELIDRFERKRALGGYNDDESGDRLMNSACCKHFIAYDLEKWKNFSRYSFNAVVTKQDMEDTYEPPFRSCIQQGKASCLMCSYNAVNGVPACAQGDLLQKARNEWGFKGYITSDCDAVATVQEYQNYTRKADDAVALVLKAGMDINCGSYLVRHTRTTIEEGKLQDKDIDRALLNLFSVQLRLGLFDGDPRKGQFGELGPQNICTIEHKMLALEAARQGIVLLKNEEKFLPLNRNVVSSIAIIGPMANNISNMGGDYTGFPCDPKSFYEGLLGYVEKASYASGCSDVPCDSDAVFNDAILTAKKADFVVVVAGLDLSQETEDHDRASLLLPGKQMTLVSSVAAASKRPIILVLTGGGPLDVSFAEGDQNIASILWVGYPGEAGGKALAEVIFGDFNPGGRLPMTWYPESFTKIAMNDMNMRANPFRGYPGRTYRFYTGNRVYGFGQGLSYTKFTYKLLSAPRTLSLSGSFTGTLTEKILHQGELDYIHVDELTSCDSLSFYVHISVANVGDRDGSHVVMLFSRAPKIFEGTPEKQLIAFDRVHTSSYGSTETSIIVIPCDHLSIVDKHGKRILPLGEHLLTLGDLEHSVSIVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TK24</accession>
    <name>A0A0D2TK24_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_012G070300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TK24"/>
    <dbReference type="STRING" id="29730.A0A0D2TK24"/>
    <dbReference type="Gramene" id="KJB76088">
        <property type="protein sequence ID" value="KJB76088"/>
        <property type="gene ID" value="B456_012G070300"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0676">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB76088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48265" checksum="30FC726248B18F1E" modified="2015-04-29" version="1">MAEGEDIQPLVCDNGTGMVKAGFAGDDAPRAVFPSIVGRPRHTGVMVGMGQKDAYVGDEAQSKRGILTLKYPIEHGIVSNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMTQIMFETFNAPAMYVAIQAVLSLYASGRTTGIVMDSGDGVSHTVPIYEGYALPHAILRLDLAGRDLTDYLMKILTERGYSFTTTAEREIVRDVKEKLSYIALDYEQELETSKTSSSVEKSYELPDGQVITIGAERFRCPEVLFQPSLIGMEAAGIHETTYNSIMKCDVDIRKDLYGNIVLSGGTTMFPGIADRMSKELSALAPSSMKIKVVAPPERKYSVWIGGSILASLSTFQQVSYWTSDLHICIYITDNAACLLGRYLGFRCGLQRPSMMNQVQRSSTGNASKCYWYGDRMKERSTVSLFLDAAWNFALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TL25</accession>
    <name>A0A0D2TL25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_007G248700</name>
        <name evidence="16" type="ORF">Gorai_019470</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB44375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000007">
        <property type="protein sequence ID" value="MBA0590778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TL25"/>
    <dbReference type="STRING" id="29730.A0A0D2TL25"/>
    <dbReference type="Gramene" id="KJB44375">
        <property type="protein sequence ID" value="KJB44375"/>
        <property type="gene ID" value="B456_007G248700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804336"/>
    <dbReference type="eggNOG" id="ENOG502QSFN">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RHVEGTQ"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045087">
        <property type="term" value="P:innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000468">
        <property type="entry name" value="PTI1-like tyrosine-protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056562">
        <property type="entry name" value="LysM2_CERK1_LYK3_4_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056563">
        <property type="entry name" value="LysM3_LYK4_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056561">
        <property type="entry name" value="NFP_LYK_LysM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052611">
        <property type="entry name" value="Plant_RLK_LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45927">
        <property type="entry name" value="LYSM-DOMAIN RECEPTOR-LIKE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45927:SF6">
        <property type="entry name" value="PROTEIN LYK5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23446">
        <property type="entry name" value="LysM1_NFP_LYK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23472">
        <property type="entry name" value="LysM2_CERK1_LYK3_4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23473">
        <property type="entry name" value="LysM3_LYK4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035989159" description="Protein kinase domain-containing protein" evidence="12">
        <location>
            <begin position="28"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="198"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="366"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="248"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB44375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0590778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="670" mass="73694" checksum="38F95AC31F34E1CA" modified="2015-04-29" version="1">MAVGRLKPCLKFCLPFLLLFFLGFTQAQQGYVNNLQLACEDPTKDNNISRGFSCNGEQRSCQSYITFRSEPPFYNTAVSIAYLLDAQATQISSLNNLSADVSSITPKSMVVVPVNCSCSGTVNDSYYQHNASYTMKFDYETYFSISNDTYQGLTTCQAMKAQNPIDYRNLEVGNKLVVPIRCACPTYNQIRAGAKYLLSYIVTWGDSISSIAETFGADEKSVLEANELSEDDIIFPFTPVLVPLSEEPSMIKPPQSSPPPASVPQIPTSPVGESDSKSSKKWVFIGVGVGIGSLLLLGLAGFLFCFFRRQRQAHKARPIAAASPPPMPPFNLKPFSDSTNYTPNSWSVSISSQGVRHAIESLTRYKFEDLKAATGNFGESNRIKGSVFRGSFQGDDAAVKVMKGDVSSEINLLKKINHTNIIRLSGFCVHEGNTYLVYEYADKGSVSDLLHSNKFQSSFTLSWKQRVQIAYDVADALNYLHNYINPPYIHKNLKSSNILLDVNFRAKVTNFGLARTIEDNDEGGLQLTRHVVGTKGYMAPEYIENGVITPKLDVFALGVIILELLSGEDAANAEKNGGEELLSASIRVVLEGDNVREKLKNFIDPSLGPEYPLDLAFSMAQLAKICVAHDLNARPSMADVLVTLSKILSSSLDWDPSSEFERSTSLTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TR25</accession>
    <name>A0A0D2TR25_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial Rho GTPase</fullName>
            <ecNumber evidence="14">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">B456_007G342600</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion outer membrane</location>
            <topology evidence="1 14">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the mitochondrial Rho GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="14"/>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB45955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TR25"/>
    <dbReference type="STRING" id="29730.A0A0D2TR25"/>
    <dbReference type="Gramene" id="KJB45955">
        <property type="protein sequence ID" value="KJB45955"/>
        <property type="gene ID" value="B456_007G342600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1707">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01893">
        <property type="entry name" value="Miro1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01892">
        <property type="entry name" value="Miro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000011">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000212">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000553">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000935">
        <property type="entry name" value="Mitochondrial Rho GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013566">
        <property type="entry name" value="EF_hand_assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013567">
        <property type="entry name" value="EF_hand_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021181">
        <property type="entry name" value="Miro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052266">
        <property type="entry name" value="Miro-EF-hand_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020860">
        <property type="entry name" value="MIRO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46819:SF1">
        <property type="entry name" value="EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08355">
        <property type="entry name" value="EF_assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08356">
        <property type="entry name" value="EF_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037488">
        <property type="entry name" value="Mt_Rho_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51423">
        <property type="entry name" value="MIRO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Miro" evidence="15">
        <location>
            <begin position="10"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Miro" evidence="15">
        <location>
            <begin position="422"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="KJB45955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="654" mass="73367" checksum="E0CE423251031D54" modified="2015-04-29" version="1">MAKSSNPEGKPGVRIVVAGDRGTGKSSLIVTAAAETFPTNVLRLLPPTRLPEDFYPDRVPITIIDTSANPEDRGKLAEELKRADALVLTYACDQPETLNRLSTYWLPELRQLEVKVPVIVVGCKLDLRDDQQQVSLEQVMSPIMQQFREIETCIECSAYKHIQIPEVFYYAQKAVLHPTGPLFDQESQTLKPRCVRALKRIFILCDHDRDGALSDAELNDFQVKCFNAPLQPSEIVGVKRVVQDKMVEGVNERGLTLTGFLFLHALFIEKGRLETTWTVLRKFGYNNDIKLSDDLIPHSSVKRAPDQSVELTNEAIEYLRGIYELFDGDLDNNLRPVEVEDVFSTAPDSPWNDVPYKDAAEKTALGGLSLDAFLSEWALMTLLDPARSLENLIYIGYPGDPSSAIRVTKRRRLDRKKQQSERNVFQCFVFGPANAGKSVLINSFLGRPYSDTYSPTIDDRYAVNVVELPGGIKKTLVLREIPEDGVAKLLSSKDSLAVCDIAVFVHDSSDESSWKRATELLVDVAGHGEDTGYEVPCLIVAAKDDLDSFPTAIQDSTRVSQDMGIEAPIPISSKLSDFNNIFRRIVNAAEHPHLSIPETEAGRSRKQYHRLINRSLMFVSGTLIVWHTTTVSFLMHSELRVLETWFAMVRFSYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TRS5</accession>
    <name>A0A0D2TRS5_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G179700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB57761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TRS5"/>
    <dbReference type="Gramene" id="KJB57761">
        <property type="protein sequence ID" value="KJB57761"/>
        <property type="gene ID" value="B456_009G179700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105766813"/>
    <dbReference type="OMA" id="CWYLVIL"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251996" description="Glycine-rich protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB57761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="11800" checksum="C0DA235064D7E875" modified="2015-04-29" version="1">MTVCRVSVFVLVGVLFLCGCIDGRKLVSEKEVHAVGESKSFFPYIPGYGGGFGWPGAGGGLGGGGGGGGGGGGGGGGKGGAGYGFGGGVGGGFGSGNGGLGGGGGGGGGGGGGGAGSHGGGFGGGYGGGFGGGSGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TTY0</accession>
    <name>A0A0D2TTY0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 18">Peroxidase</fullName>
            <ecNumber evidence="4 18">1.11.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">B456_009G295200</name>
        <name evidence="21" type="ORF">Gorai_012989</name>
    </gene>
    <organism evidence="20 22">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="21 23" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="21" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="21">8</strain>
            <tissue evidence="21">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>2 a phenolic donor + H2O2 = 2 a phenolic radical donor + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:56136"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:139520"/>
            <dbReference type="ChEBI" id="CHEBI:139521"/>
            <dbReference type="EC" id="1.11.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15 18">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 18">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="15 18">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Ascorbate peroxidase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.7" evidence="4 18"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000009">
        <property type="protein sequence ID" value="MBA0596158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2TTY0"/>
    <dbReference type="STRING" id="29730.A0A0D2TTY0"/>
    <dbReference type="Gramene" id="KJB60224">
        <property type="protein sequence ID" value="KJB60224"/>
        <property type="gene ID" value="B456_009G295200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765828"/>
    <dbReference type="eggNOG" id="ENOG502QT8W">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RQSACPR"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140825">
        <property type="term" value="F:lactoperoxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00693">
        <property type="entry name" value="secretory_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000006">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000001">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000823">
        <property type="entry name" value="Peroxidase_pln"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033905">
        <property type="entry name" value="Secretory_peroxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388:SF24">
        <property type="entry name" value="PEROXIDASE 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31388">
        <property type="entry name" value="PEROXIDASE 72-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00461">
        <property type="entry name" value="PLPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 18" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 17" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 18" id="KW-0349">Heme</keyword>
    <keyword evidence="18" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="10 15 18" id="KW-0408">Iron</keyword>
    <keyword evidence="7 15 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0964">Secreted</keyword>
    <keyword evidence="18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034013708" description="Peroxidase" evidence="18">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="19">
        <location>
            <begin position="28"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="16">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="38"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="124"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="17">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600823-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU362060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="KJB60224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="MBA0596158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <sequence length="323" mass="34865" checksum="0430B5933B2A81A8" modified="2015-04-29" version="1">MASSFSRFSQTLLLLVVFWGITSSSNAQLSTDYYSESCPNLFSTVKFTVHSAIMNEARMGASLLRLFFHDCFVNGCDGSLLLDDTSSFTGEKNAVPNRNSARGFDVIDDIKSAVENVCPGVVSCADILAIAARDSVKILGGPNWDVKLGRRDARSASQAAANNGIPAPTSNLNRLISRFNALGLSTGDLVALSGAHTIGQARCTSFRARIYNESNIDLSFAKTMQSNCPRSSGSGDNNLSPLDIQTPTYFDNKYFNNLIGKRGLLHSDQELFNGGSTDSIVRAYSKNPSSFSSDFVTAMIKMGDISPLTGSKGEIRKNCRRVN</sequence>
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    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
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                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
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                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">8</strain>
            <tissue evidence="6">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the GRAS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB59366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2TV74"/>
    <dbReference type="Gramene" id="KJB59366">
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        <property type="gene ID" value="B456_009G251800"/>
    </dbReference>
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    <dbReference type="eggNOG" id="ENOG502QPVN">
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    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03514">
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        <property type="match status" value="1"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
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            <end position="90"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
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    </evidence>
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        <source>
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</entry>
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        <lineage>
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    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
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                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
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                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
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                <person name="Walford S.A."/>
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                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
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                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_009G359200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="156" mass="18283" checksum="B8CC3B0EA65E000D" modified="2015-04-29" version="1">MIIANNIKTTIPQTKSAKEYLMFVEECFCSMDKPLVGTLMAQLMTMKYDGSRGMQEHIIEVAKDLKQQPTSLRRRKNLPVNVSNGDKKEQMADKCHFCKKGHYQKDFQKHKAWFEKKGEFYVFVCFELNLIEVHNNTQWLDSIFTTHISNMIHGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TYT9</accession>
    <name>A0A0D2TYT9_GOSRA</name>
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        <recommendedName>
            <fullName evidence="7">DUF547 domain-containing protein</fullName>
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    <gene>
        <name evidence="5" type="ORF">B456_008G070900</name>
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    <organism evidence="5 6">
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        <name type="common">Peruvian cotton</name>
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        <lineage>
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    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB48480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_008G070900"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="entry name" value="DUF547"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025757">
        <property type="entry name" value="MIP1_Leuzipper"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054:SF18">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23054">
        <property type="entry name" value="TERNARY COMPLEX FACTOR MIP1, LEUCINE-ZIPPER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Lzipper-MIP1"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002252184" description="DUF547 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Ternary complex factor MIP1 leucine-zipper" evidence="4">
        <location>
            <begin position="76"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="DUF547" evidence="3">
        <location>
            <begin position="443"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF04784"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF14389"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB48480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="656" mass="74663" checksum="764E7C8B5212B0A8" modified="2015-04-29" version="1">MRRLRVAMAVLKSCFVQVLSIDSWCLILSHSSFSVKQRVEEDGLDDSLEESNRIKLDMRHLKNSVKTPKKQSSTPHTEVQSSLKQEILQLEKRLQDQFEIRRAVETALGYQISSHEHTNETPVSISKPPTELIKEIAVLELEVVYLEQYLLSLYRKAFDQQVSSISPAKRDERLKTPIHTPSVRDERLKTPVTTPSKKDERLKTPVHTPSGRFLEVPRLDDDASKVDNSAVRSGYNENSWKEPIDIVGEKLLDSGVNRCYSTLSQRSKFPSWTSPLDETLADKAVRACHSQPLSMMEYAQNASNIISLAEHLGTCISDHAPDTPNKLSEDMIKCMSVIYCKLTDPPLIQNSFSSPISSVSSASAFSPQEQHDMWSPGLRNNSSFDVRLDNPFHVEGLKEFSGPYSTMLEVPWIFRDSEKLAEVENLLQNFRSLICKLEEVDPRKLRHEEKLAFWINIHNSLVMHAFLAYGIPQNNVKRFFLLLRAAYNIGGHTISADTIQSSILGCRMPRPGQWLRLLISARTKFKAGDRRQAYAIEHPEPLLHFALGSGNHSDPAVRAYTPKNVIQELETAKQEYIRATFGVRKDLKILLPKLLESFAKDSSLCQAGIIEMVRQSLPESLRRSIRKCQVGKSRKSIEWSPHDFTFRYLISKELVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2TZS3</accession>
    <name>A0A0D2TZS3_GOSRA</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G406600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="B456_009G406600"/>
    </dbReference>
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        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
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        <property type="component" value="Chromosome 9"/>
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    </dbReference>
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        <property type="entry name" value="RNA_pol_mitovir"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34456">
        <property type="entry name" value="MITOVIRUS RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34456:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05919">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB62219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="174" mass="19613" checksum="425A3A7DEDBDA4F6" modified="2015-04-29" version="1">MEEEREQLSVREGGNCRLGLQSALIAQLFENSLSAFVCSAFRSYPFRAPFLKKIPQSRAAFVLFGLLLYSSWPIFTLTHHLLVMYCAERVHPGQKFYKYAILGDDVVICGIEIAKIYKQTLAELGVDISMSKSLILHSGYAEFGKRFWCKGLTVDLSPVLIRNLLPIATMKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UDF3</accession>
    <name>A0A0D2UDF3_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_010G161600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
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            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB66864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB66864"/>
        <property type="gene ID" value="B456_010G161600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB66864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="144" mass="16039" checksum="F3B94F4094B94FB7" modified="2015-04-29" version="1">MGKGQGLKVKVALQRCHQRSFSDPNHGIDQNFPLALSFLMCFHRELLEIPLGFSFADHLALMPSPLVSMSSPIGEVPNDFHFSLLLLLLFFYFIFAFKASGHHFTVAALRRQIEPPPLNNHGTLIVASSHCVQCLDHLDLSTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UF42</accession>
    <name>A0A0D2UF42_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b561 and DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">B456_010G187900</name>
        <name evidence="18" type="ORF">Gorai_008110</name>
    </gene>
    <organism evidence="17 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="18 20" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="18" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="18">8</strain>
            <tissue evidence="18">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">May act as a catecholamine-responsive trans-membrane electron transporter.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="11">Binds 2 heme b groups non-covalently.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001749">
        <property type="protein sequence ID" value="KJB67384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000010">
        <property type="protein sequence ID" value="MBA0598343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UF42"/>
    <dbReference type="STRING" id="29730.A0A0D2UF42"/>
    <dbReference type="Gramene" id="KJB67384">
        <property type="protein sequence ID" value="KJB67384"/>
        <property type="gene ID" value="B456_010G187900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105773853"/>
    <dbReference type="eggNOG" id="KOG4293">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="NNEMVIY"/>
    <dbReference type="OrthoDB" id="2419613at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 10"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09629">
        <property type="entry name" value="DOMON_CIL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1770:FF:000007">
        <property type="entry name" value="Cytochrome b561 and DOMON domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045265">
        <property type="entry name" value="AIR12_DOMON"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017214">
        <property type="entry name" value="UCP037471"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23130:SF167">
        <property type="entry name" value="CYTOCHROME B561 AND DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04526">
        <property type="entry name" value="DUF568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037471">
        <property type="entry name" value="UCP037471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220995" description="Cytochrome b561 and DOMON domain-containing protein" evidence="14">
        <location>
            <begin position="24"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="15">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="16">
        <location>
            <begin position="168"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053871"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037471"/>
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    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR037471-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="KJB67384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="MBA0598343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="395" mass="43583" checksum="827139024C7A54D4" modified="2015-04-29" version="1">MARMLELALYLCLFMCLILTCYAQTCAKYAFSSNRVFKSCTHLPVLNSFLHYNYDVSGKLEIAYRHTGITSSRWVAWAINPTSKAMVGSQALVAYQLSDGSMRAYTSPITQYQTQLQEGELSFDVSDLSATYANNEIIIFATLGFPSNDTTLNQVWQEGAMSGNTPQMHATSGPNVQSMGTLNLLSRQAGTIGGRTSTQRKQDIHGVLNAVSWGILMPLGAIIARYLKVFKSADPAWFYLHASCQFSAYVVGVAGWSTGLKLGSESPGIQYDAHRTIGIILFCLGTLQVFALLVRPKPDHKYRVYWNIYHHLVGYTVVILSVINIFKGLDILEHEKKWKNAYIGVIIALACSGVVLEAYTWFLVLRRKRSESAGKLSHGINGAHGNGVNAHTANC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UNP3</accession>
    <name>A0A0D2UNP3_GOSRA</name>
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            <fullName evidence="6">Large ribosomal subunit protein bL21m</fullName>
        </recommendedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
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        <property type="protein sequence ID" value="KJB57550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="29730.A0A0D2UNP3"/>
    <dbReference type="Gramene" id="KJB57550">
        <property type="protein sequence ID" value="KJB57550"/>
        <property type="gene ID" value="B456_009G169600"/>
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    <dbReference type="KEGG" id="gra:105767994"/>
    <dbReference type="eggNOG" id="KOG1686">
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    <dbReference type="OrthoDB" id="5994at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_bL21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="bL21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="bL21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_bL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_bL21_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="L21p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB57550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="259" mass="29079" checksum="8B1772C22B309A21" modified="2015-04-29" version="1">MAHRRCLLSLARHATAIISQKKMPPLSAVEVLTRKPNPAITIPNSELSWFSFWSHSRHFSSSKSEDSETEVEVEMEEASDVEAENDNAASDLGRDYSPEEKETEAVAIGYKVLGPLQRSDRVFKDYEPVFAVVQIGSHQFKVSNGDSIFTERLKFCEVNDKLILNKVLLLGSPTQTIIGRPILPDAAVHAVVEEHALDAKVIIFKKKRRKNYRRTKGHRQELTKLRITDIQGIEKQEIKTDGKPLKAAVKNPEKIAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UUK0</accession>
    <name>A0A0D2UUK0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G154500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UUK0"/>
    <dbReference type="STRING" id="29730.A0A0D2UUK0"/>
    <dbReference type="Gramene" id="KJB72036">
        <property type="protein sequence ID" value="KJB72036"/>
        <property type="gene ID" value="B456_011G154500"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0582">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WDFFFLP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902456">
        <property type="term" value="P:regulation of stomatal opening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047173">
        <property type="entry name" value="STRAD_A/B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE FRAY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48014:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BLUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB72036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="193" mass="21192" checksum="57FED7C13FB7C1C4" modified="2015-04-29" version="1">MAYEQEDHPKLQFPIDSNSYNITAEIGAGVCSKVYTAQCLPINSTVVAIKSIDLDQSNADFRNLVGRETNTSSLLSHLNILNPHSSFTAGNRLWVVMPFMPGGSLDSIIASSVPNGIQEQCIAIVLKETLTALSYLHSRGHLHRDIKASNILLDDNGRVKLADFGVSLSFYASSSAYRLGSSTFSPQYWRPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UVY4</accession>
    <name>A0A0D2UVY4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">B456_011G206900</name>
        <name evidence="13" type="ORF">Gorai_006404</name>
    </gene>
    <organism evidence="12 14">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="13 15" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">8</strain>
            <tissue evidence="13">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB72974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000011">
        <property type="protein sequence ID" value="MBA0600208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UVY4"/>
    <dbReference type="Gramene" id="KJB72974">
        <property type="protein sequence ID" value="KJB72974"/>
        <property type="gene ID" value="B456_011G206900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105775969"/>
    <dbReference type="eggNOG" id="ENOG502QRTV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MVWDEIE"/>
    <dbReference type="OrthoDB" id="418615at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046959">
        <property type="entry name" value="PRK1-6/SRF4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007:SF38">
        <property type="entry name" value="LEUCINE-RICH REPEAT PROTEIN KINASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48007">
        <property type="entry name" value="LEUCINE-RICH REPEAT RECEPTOR-LIKE PROTEIN KINASE PXC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220785" description="Protein kinase domain-containing protein" evidence="10">
        <location>
            <begin position="28"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="345"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="KJB72974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="MBA0600208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="624" mass="68109" checksum="E6CB8BCEB3800596" modified="2015-04-29" version="1">MAVARFFRLFPLLLSSSFVVLSPLASSASDSEALLRLKESLISAGALDSWVPGSNPCNGSQGTWEGLRCSNGVVTGLRLEGMGLSGYIDVEALVEIQGLRVFSVANNSFTDVIPEINRLGSLKVLFLSMNQFSGVIPSEYFDNMGSLKKVWLSNNKFTGNIPVSLSRLSRLTDLHLENNQFGGQIPAFDNPTLKYINVSNNQLEGEIPSSLSKFNADSFAGNPGLCGEQVGVECSKADQPTPNDTSKTIVAALITLGAVLFIAVIFFAFRWRKKKQQNDLKELKTGNSNDAVEVPVSVITDKKEESVKSACSTRKDSNPRRLSTVTELVMVNDEKGVIGLPDLLKSAAEVLGNGSLGSSYKVKMTNGVALVVKRMRQMNALGNDAFDAEVRKLGNLRHPNVLPPLAYHYRKEEKLFVYEYFSKGSLFYQLHGDGGKSGGELDWPTRVKIVRGIAEGLDYLHKEFPLRDVPHGNLKSSNVLLGPDNHPFLSDYGFHPLVNIDGLQALCAYKTPEAVQQKTVSPKSDVYCLGIIILEILTGEIPCQCLNDSKGGTDIVQWVASAFSEGRQAELLDTGMEGCRNSVGSMEKLLRVGALCTETSPEKRLDIKETIRMIEEIQVEGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UXS4</accession>
    <name>A0A0D2UXS4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF674 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_011G247300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UXS4"/>
    <dbReference type="Gramene" id="KJB73739">
        <property type="protein sequence ID" value="KJB73739"/>
        <property type="gene ID" value="B456_011G247300"/>
    </dbReference>
    <dbReference type="OMA" id="RSHKILY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007750">
        <property type="entry name" value="DUF674"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33103:SF110">
        <property type="entry name" value="DUF674 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33103">
        <property type="entry name" value="OS01G0153900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05056">
        <property type="entry name" value="DUF674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="25258" checksum="99C4220CB67EC06F" modified="2015-04-29" version="1">MAATKPTTVSKKLLIDPKSDRILFAEAGKDFVDFLFYIMSLPVGTVVRLLGKQRTVGCLGNIYESIENLNDYYYMKSAATKVILLKPMSKYTNLYWCKNHQNYNGGTAYVANHPTAACPSCGHYFMKSNDVLFVNPTNNGVPDSGEEALIKRPATFMIMDDLVVRPMYTNSIITLLDKFNIKDVNDLEEKTIGVGVNEAVELLRASMQSKTVLTDVFLGGKKKSSEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYB8</accession>
    <name>A0A0D2UYB8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Factor of DNA methylation 1-5/IDN2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_011G265400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2UYB8"/>
    <dbReference type="STRING" id="29730.A0A0D2UYB8"/>
    <dbReference type="Gramene" id="KJB73986">
        <property type="protein sequence ID" value="KJB73986"/>
        <property type="gene ID" value="B456_011G265400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZM6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GVKMIGQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080188">
        <property type="term" value="P:gene silencing by siRNA-directed DNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045177">
        <property type="entry name" value="FDM1-5/IDN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005379">
        <property type="entry name" value="FDM1-5/IDN2_XH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596:SF82">
        <property type="entry name" value="FACTOR OF DNA METHYLATION 5-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21596">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03469">
        <property type="entry name" value="XH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Factor of DNA methylation 1-5/IDN2" evidence="2">
        <location>
            <begin position="64"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB73986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="164" mass="18942" checksum="6A81348F457BAC23" modified="2015-04-29" version="1">MSDQIAALKEQLEETSEALKDMESRYSCLTVKQILTNRELQDARKESISGLNDVLTSRTTLVVKRMGEIDQKAFEVASSRKFPNKDWQETCAKLCSLWQQNVQDPKWHPFKMINIRGNLQEIVDEDDQKLKELRNEYGDVVYEAVSTALMEMNEYNASGRYAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2UYR5</accession>
    <name>A0A0D2UYR5_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_009G3555002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
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            <taxon>Spermatophyta</taxon>
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        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Arick M.A. 2nd"/>
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                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
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                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
            <location evidence="7">Cell wall</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the expansin family. Expansin A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000013">
        <property type="protein sequence ID" value="MBA0601998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2V9E2"/>
    <dbReference type="STRING" id="29730.A0A0D2V9E2"/>
    <dbReference type="Gramene" id="KJB78839">
        <property type="protein sequence ID" value="KJB78839"/>
        <property type="gene ID" value="B456_013G022200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105784181"/>
    <dbReference type="eggNOG" id="ENOG502QR06">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MANWVDT"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009664">
        <property type="term" value="P:plant-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22274">
        <property type="entry name" value="DPBB_EXPA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.10:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.760:FF:000001">
        <property type="entry name" value="Expansin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.760">
        <property type="entry name" value="Expansin, cellulose-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007118">
        <property type="entry name" value="Expan_Lol_pI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002963">
        <property type="entry name" value="Expansin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007112">
        <property type="entry name" value="Expansin/allergen_DPBB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007117">
        <property type="entry name" value="Expansin_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036749">
        <property type="entry name" value="Expansin_CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31867">
        <property type="entry name" value="EXPANSIN-A15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01357">
        <property type="entry name" value="Expansin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01226">
        <property type="entry name" value="EXPANSIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01225">
        <property type="entry name" value="EXPANSNFAMLY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00837">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49590">
        <property type="entry name" value="PHL pollen allergen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50843">
        <property type="entry name" value="EXPANSIN_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50842">
        <property type="entry name" value="EXPANSIN_EG45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5034010896" description="Expansin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like EG45" evidence="8">
        <location>
            <begin position="50"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Expansin-like CBD" evidence="9">
        <location>
            <begin position="174"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB78839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="MBA0601998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="258" mass="28101" checksum="9FBB1D3C03D07CD5" modified="2015-04-29" version="1">MANWVDTCLVSLLFIIVTVEARIPGVYSDGAWQSAHATFYGGSDASGTMGGACGYGNLYSQGYGVNTAALSTALFNNGFSCGACFEIKCVNQPQWCHSGSPSIFITATNFCPPNYALPNDNGGWCNPPRSHFDLAMPMFLKIAEYRAGIVPVSYRRVPCRKRGGIRFTINGFRYFNLVLITNVAGSGDIVKASVKGSKTGWMSLSRNWGQNWQSNAVLVGQSLSFRVTGSDRRTSTSWNIAPSNWQFGQTFTGKNFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA22</accession>
    <name>A0A0D2VA22_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Receptor-like serine/threonine-protein kinase</fullName>
            <ecNumber evidence="19">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">B456_013G034400</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="19"/>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VA22"/>
    <dbReference type="Gramene" id="KJB79124">
        <property type="protein sequence ID" value="KJB79124"/>
        <property type="gene ID" value="B456_013G034400"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUNW">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GEPSWIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14066">
        <property type="entry name" value="STKc_IRAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.90.10.30:FF:000003">
        <property type="entry name" value="Os04g0303100 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000248">
        <property type="entry name" value="S-receptor-like kinase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000178">
        <property type="entry name" value="serine/threonine-protein kinase PBS1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.90.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001480">
        <property type="entry name" value="Bulb-type_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051343">
        <property type="entry name" value="G-type_lectin_kinases/EP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024171">
        <property type="entry name" value="SRK-like_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976">
        <property type="entry name" value="G-TYPE LECTIN S-RECEPTOR-LIKE SERINE/THREONINE-PROTEIN KINASE SD2-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47976:SF30">
        <property type="entry name" value="RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01453">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08276">
        <property type="entry name" value="PAN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000641">
        <property type="entry name" value="SRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00108">
        <property type="entry name" value="B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="alpha-D-mannose-specific plant lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50927">
        <property type="entry name" value="BULB_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 19 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0675">Receptor</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 19" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002253421" description="Receptor-like serine/threonine-protein kinase" evidence="22">
        <location>
            <begin position="31"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Bulb-type lectin" evidence="24">
        <location>
            <begin position="50"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="25">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="23">
        <location>
            <begin position="479"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="KJB79124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="787" mass="87287" checksum="B5C61A2AE2CC1E18" modified="2015-04-29" version="1">MIMNTNTSSAFVMITLLILLIIPSSFFIDAEIMDYPSFVNGPNSWRNTPSTDFSFWESAGVRPILVYGMFACGFHCSFVGENCLFAVSIFKSSSEGNSSFSAQVVWSANPNNPVEMQALLELTSEGKLNLKDANNTVVWSPSTPGKSISRLNLTAEGNLMLFDETNYIVWQSFDHPTDSLVRGQRLVSGQKLRANVSSADSSESLYSFAVIDGKFVAYMDSDPSQSYYQSSSILSTEPEFKNGQFGSFHVADSANFIQLGSDGHLKAYELKESGWEGTDLLPIDPCSYPLACGNYGVCLEKGCSCPDDISENEAVFFRPIDFTTPNLGCSAISPISCESSLLQSFLELSSGYSQRVYTSLFSNTIALEDCKEACLKNCSCKAATYRKGSCYFLSQVDSLKKTNSSDLTFIKTHFPERKKQNTSVIVGSTLGAIFGVFLICTLIFLRFKKGFQEVEEDFLDNMLGMPTRFSYEELKNVTKNFSNKLGEGGFGSIFQGTLPSGSEVAVKHLVGFGPVNKSFMTEVQTIGSIHHFNLVSLVGFCAQKFNRLLVYEYMANGSLDRWIFNKNRDLALGWQIRKKIILDIAKGLAYLHEDCNQKIVHLDIKPQNILLDEHFNAKVSDFGLSKLIGKDQSRVITTMRGTPGYMAPEWLSSVITEKVDVYSFGIVVLEILCGRRNVDESHLEEDRHLLGLFKRKQEEGQLMDLVDKCSDDMQSNAAEVVQMMKVAAWCVQTKHARRPSMSIVVKLFEGSVDVAGNLNEDFQNGLTPEAMETFASIVLPCLLSGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VA71</accession>
    <name>A0A0D2VA71_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_013G037600</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Golgi apparatus membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasmic vesicle</location>
            <location evidence="13">COPI-coated vesicle membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the COPG family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB79199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VA71"/>
    <dbReference type="STRING" id="29730.A0A0D2VA71"/>
    <dbReference type="Gramene" id="KJB79199">
        <property type="protein sequence ID" value="KJB79199"/>
        <property type="gene ID" value="B456_013G037600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105781828"/>
    <dbReference type="eggNOG" id="KOG1078">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="1074925at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000071">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000078">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1480:FF:000002">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000011">
        <property type="entry name" value="Coatomer subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="15">
        <location>
            <begin position="27"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="16">
        <location>
            <begin position="622"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="17">
        <location>
            <begin position="770"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR037093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB79199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="887" mass="98358" checksum="CA788F4285F80064" modified="2015-04-29" version="1">MAQPLVKKDDDRDDEADYSPFLGIEKGAVLQEARVFNDPQLDPRRCSQVITKLLYLLNQGETFTKVEATEVFFAVTKLFQSKDIGLRRMVYVMIKELSPSADEVIIVTSSLMKDMTSKTDMYRANAIRVLCRITDGTLLTQIERYLKQAIVDKNPVVASAALVSGIHLLQTNPEIVKRWSNEVQEAVQSRAALVQFHALALLHQIRQNDRLAVNKLVSSLTKGSVRSPLAQCLLIRYTSQVIRESANNNQAGDRPFYDFLEGCLRHKAEMVIFEAARAITELNGVTSRELTPAITVLQLFLSSSKPVLRFAAVRTLNKVAMTHPMAVTNCNIDMESLISDQNRSIATLAITTLLKTGNESSVDRLMKQITNFMSDIADEFKIVVVEAIRSLCLKFPLKHRSLMNFLSNILREEGGFEYKKAIVDSIVILIRDIPEAKESGLLHLCEFIEDCEFTYLSAQILHFLGIEGPKTSDPSKYIRYIYNRVHLENATVRAGAVSTLAKFGAMVDTLKPRVFVLLRRCLFDNDDEVRDRATLYLNTLGGDGAVVETGEDVKEFLFGSLDIPLVNLENSLKNYEPSEEAFDINSVPKEVKTQPLAEKKAPGKKPTGLGAPPAGPPSTVDAYEKLLSSIPEFANFGKLFKSSAPVELTEAETEYAVNVVKHIFDGHVVFQYNCTNTIPEQLLENVTVIVDASEAEEFAEVASKPLRSLPYDSPGQTFVAFEKPEGVPAIGKFSNMLRFIVKEVDPSTGEAEDDGVEDEYQLEELEVVAADYMLKVGVSNFRNAWETMDADCERVDEYGLGPRESLAEAVNAVINLLGMQPCEGTEVVPNNSRSHTCLLSGVYIGNVKVLVRLQFGLDGPKDVAMKLAVRSEDEAVSDAIHEIVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VWT4</accession>
    <name>A0A0D2VWT4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_012G079600</name>
        <name evidence="16" type="ORF">Gorai_004367</name>
    </gene>
    <organism evidence="15 17">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="16 18" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="16" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="16">8</strain>
            <tissue evidence="16">Leaf</tissue>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VWT4"/>
    <dbReference type="STRING" id="29730.A0A0D2VWT4"/>
    <dbReference type="Gramene" id="KJB76240">
        <property type="protein sequence ID" value="KJB76240"/>
        <property type="gene ID" value="B456_012G079600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779471"/>
    <dbReference type="eggNOG" id="KOG0345">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000877">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="48"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="269"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="501"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="518"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB76240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="MBA0601181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="593" mass="66227" checksum="97C50805DB71E756" modified="2015-04-29" version="1">MDSNTQNPGSALTDTRFSDLKPPLSEPVLEALSQAGFKFCTPVQAATIPLLCSFKDVAVDAATGSGKTLAFLIPIVEILRRSSSSPPKRHQVMGIIISPTRELSSQIYNVAQPFISTLPNVKSMLLVGGVEVKADVKKIEEEGANLLIGTPGRLYDIMDRMDVLDFRNLEILILDEADRLLDMGFQKQINYIISRLPKLRRTGLFSATQTEAVEELSKAGLRNPVRVEVRAETKSLSNSVSSEQLASSKTPSGLHLEYLECEADKKASQLVDLLVKTKSKKVIVYFMTCACVDYWGVVLPCLNALKGFSLIALHGKMKQTAREKALASFTSLSSGILLCTDVAARGLDIPGVDCIVQYDPPQDPNVFVHRVGRTARLGRQGSAIVFLFPKEEAYIEFLRIRRVPLQERKCIDDVADVVPQIRSAALKDRDVMEKGLRAFVSFIRAYKEHHCSYIFRWKELEIGKLGTGYGLLQLPSMPEVKHHSLSTEGFTPVENINMDDIKFKDKSREKQRKKNLQTKKEREQQESKPEKPKKATNAAASVMRKKTAKQRRAAQTIEDEEELTREYRLLKKLKKGAIDETEFAKLTGAEDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2VYK4</accession>
    <name>A0A0D2VYK4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate isopentenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_012G122700</name>
        <name evidence="7" type="ORF">Gorai_004662</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="7">8</strain>
            <tissue evidence="7">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000012">
        <property type="protein sequence ID" value="MBA0601487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2VYK4"/>
    <dbReference type="STRING" id="29730.A0A0D2VYK4"/>
    <dbReference type="Gramene" id="KJB77135">
        <property type="protein sequence ID" value="KJB77135"/>
        <property type="gene ID" value="B456_012G122700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1384">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GIWEEQV"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009824">
        <property type="term" value="F:AMP dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.890">
        <property type="entry name" value="Crystal structure of tRNA isopentenylpyrophosphate transferase (bh2366) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF86">
        <property type="entry name" value="ADENYLATE ISOPENTENYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB77135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="MBA0601487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36128" checksum="62D8EBD66679FE4A" modified="2015-04-29" version="1">MDSSSPPHHHSNQNKTKIIVTMGATGCGKSRLSVDLATHFPHSQIINSDKMQLYNGLDITTNKIPPHERKGVPHFLLGDLDTIDADVLPSQFRSAAGLTIANIVSRGNLPLLVGGSNSFIHALLVETFDPQVDVFTGPDSVTHLLRYDCCFLWVDVAWSVLSDYLCERVDEMLESGMLEELAQFYEPTKVGVRVGLRKAIGVSEFDEYFRKYPPWESEANGRIPKEGCDQARKEAYEEAVRLIKDNTCILAKRQIGKIMRLRKAGWDLKRLDATATFRAMMMKKKKNKSSSAASSDLEWRDIWEREVMEPSVKAVRRFLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2W1V4</accession>
    <name>A0A0D2W1V4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_013G016300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB78755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2W1V4"/>
    <dbReference type="Gramene" id="KJB78755">
        <property type="protein sequence ID" value="KJB78755"/>
        <property type="gene ID" value="B456_013G016300"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB78755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="84" mass="9572" checksum="4417BBD292D86FC0" modified="2015-04-29" version="1">MSKLKSKEKVDDGDRSWLELLNGVETSTSSENEKLHKLTQMVLSKFVARLVTKMENKMMIEKEGLKSCHEAGVEEGKRDYLIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2M096</accession>
    <name>A0A0D2M096_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alcohol dehydrogenase class-3</fullName>
            <ecNumber evidence="6">1.1.1.1</ecNumber>
            <ecNumber evidence="5">1.1.1.284</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Alcohol dehydrogenase class-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutathione-dependent formaldehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">B456_001G182700</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="6"/>
    <dbReference type="EC" id="1.1.1.284" evidence="5"/>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2M096"/>
    <dbReference type="STRING" id="29730.A0A0D2M096"/>
    <dbReference type="Gramene" id="KJB10072">
        <property type="protein sequence ID" value="KJB10072"/>
        <property type="gene ID" value="B456_001G182700"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0022">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ACHKGWD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF58">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="22">
        <location>
            <begin position="34"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="21">
        <location>
            <begin position="210"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="KJB10072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="357" mass="38517" checksum="F10A8BC35FA66050" modified="2015-04-29" version="1">MATAGEVITCKAAVAYEPNKPLVIEDVQVAPPQAGEVRVKILFTALCHTDAYTWSGKDPEGLFPCILGHEAAGIVESVGEGVTEVQPGDHVIPCYQAECKECKFCKSGKTNLCGKVRMATGAGIMMNDRKSRFSINGKPIYHFMGTSTFSQYTVVHDVSVAKVDPQAPLDKVCLLGCGVPTGLGAVWNTAKVEPGAIVAIFGLGTVGLAFDIAKNFGVTEFVNPKDYDKPIQQVLVDLTDGGVDYSFECIGNVSVMRAALECCHKGWGTSVIIGVAASGQEISTRPFQLVTGRVWKGTAFGGFKSRSQVPWLVDKYMKKEIKIDEYITHNLTLGEINKAFDLMHEGGCLRCVLKMHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MJS6</accession>
    <name>A0A0D2MJS6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_003G0564002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MJS6"/>
    <dbReference type="STRING" id="29730.A0A0D2MJS6"/>
    <dbReference type="Gramene" id="KJB18502">
        <property type="protein sequence ID" value="KJB18502"/>
        <property type="gene ID" value="B456_003G0564002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB18503">
        <property type="protein sequence ID" value="KJB18503"/>
        <property type="gene ID" value="B456_003G0564002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2854">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052700">
        <property type="entry name" value="Carb_kinase_PfkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320:SF3">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43320">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="5">
        <location>
            <begin position="174"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB18502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="260" mass="28075" checksum="063E455545A21C52" modified="2015-04-29" version="1" fragment="single">MSFLTSISSPPQINSLFCSPIFSLYRFHSPLFSSLYHRKQSYGSGRIIRELGFLGDFRGKGRVTSGSMGKEKGGFFWVSSPCSSGGSCSCSSSKGDEFESEEDEEEVDDEEEGARSFCVLPDRWDVLGLGQAMVDFSGMVDDEFLERLGLEKGTRKVVNHEERGRVLQAMDGCSYKAAAGGSLSNSLVALARLGYKPIGGPALNVAMAGSVGSDPLGGFYRAKLHRANVNFLSEPIKDGTTGTVIVLTTPDAQRTMLAYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MSX9</accession>
    <name>A0A0D2MSX9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_004G032700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MSX9"/>
    <dbReference type="STRING" id="29730.A0A0D2MSX9"/>
    <dbReference type="Gramene" id="KJB22162">
        <property type="protein sequence ID" value="KJB22162"/>
        <property type="gene ID" value="B456_004G032700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QT38">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="LAMWEDI"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056699">
        <property type="entry name" value="DUF7797"/>
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    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47527">
        <property type="entry name" value="RING/FYVE/PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47527:SF3">
        <property type="entry name" value="RING_FYVE_PHD ZINC FINGER SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25073">
        <property type="entry name" value="DUF7797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00439">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="388"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="7">
        <location>
            <begin position="694"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="461"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="542"/>
            <end position="562"/>
        </location>
    </feature>
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            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB22162.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="822" mass="88702" checksum="3AC63F318D878B7B" modified="2015-04-29" version="1">MDPEVGVDENAAFEPSPAVGEKRGVENGAVSASKKQRCGGGLKRVAEIVLVLSTMGKMRGGKNPTSAEMSLMAEARETLAEMCGEMAPKDIVGRDAIGNVIEELGLNSNLKEQRLGFRDMGMSISQKVLFAKMKMEEPKKFTTPGTYTSQPLQTNIGGSAENRGALHAARLLPSDQPIHPAVSSGGIPVSLPPAHVAAAGSAPLQHQLPTSDVKMPTMSTGLPSGHLGRDSSSFAYPRVERPQIKLDGGSNAASYVSQMPVNSSASHPPANAPTWSIQAQSAGLAKSGQENKVLTHNPIKVEGSSGLTTAQMNNQAVRDQTFRPFITQTAPGTFPSVHQPVQGANFTQAPPFINNHNEIARIVQKLLQPKLPAHPTWTPPSREYMNKALTCQTCKVTINDVETVLICDACEKGFHLKCLQSNNQKAIPRGEWHCARCLSFCNGKPLPPKYGRVMRSINVSKVPSSTAEPQSSSEKKMENLGSTVNHEKVTANGSSASQTLAMATAVDSNSVESASGSKVPKENLTKPLEAVCDLPSVGTVNERPEEHSQMTESSNHEERKDPTSTSEPADTSDNTICKKADHSQPSDNSKDIQTGQQNFAEVPSNNCHVESSGVKDMEKDCSKGDIDCIKQINQSEQDAVAAQVNPSGNSGANTEISRHLEFSSDGLRAVEWAGDILQVVDGKKFYQYCCIDGIIYKVHDHALVHSGQDKLIPSKLQAMWEDAKTGSKWVVVKRCYFPSDLPEGVAHPCPPEISEVYESNNDSTVMASAIQCPCEVLPADKFKEESERRSQLGIEANERSKAIFLCRWLYDEFNGSFQSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MUX0</accession>
    <name>A0A0D2MUX0_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G073100</name>
        <name evidence="4" type="ORF">Gorai_014272</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
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            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000004">
        <property type="protein sequence ID" value="MBA0583413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MUX0"/>
    <dbReference type="Gramene" id="KJB22911">
        <property type="protein sequence ID" value="KJB22911"/>
        <property type="gene ID" value="B456_004G073100"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22912">
        <property type="protein sequence ID" value="KJB22912"/>
        <property type="gene ID" value="B456_004G073100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="AVHGHIW"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000366">
        <property type="entry name" value="Pentatricopeptide (PPR) repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000344">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000031">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000804">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF376">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL DOMAIN SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="250"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="351"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB22912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0583413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="65114" checksum="83459C292BF1E6DA" modified="2015-04-29" version="1">MALKTITILNRLSIQPIPLGPPQNTQAIVDQIKQCSKLYQLEMIYATMVKTNANQDCFLSNQFVTACSSFRRMDYAILAFTEVEKPNVFVYNALIKALVHCHHPFTALDYYKHMLRARVWPTSFTFSSLVKACCLVSEFGFGESVHGHVWKHGFKSHVFVQTALIDFYANVGKIIESKRVFDEMPERDVFAWTTMISGFLKAGDLGSSRRLFDETPERSTATWNAMIDGYARVGDVASAELLFNQMPVKDTISWTTMINCYSQNKQYAEALVLFEEMRRYKVSPDEVTMASVISACAHLGALDTGKEIHNYLMQNFFDLDVYIGSALIDMYAKCGGLERSLLVFFKLREKNLFCWNSVIEGLAVHGHAVEALAMFDRMERQHVKPNRVTFVSVLTACTHAGLVEVGRQRFLSMTRDYSILPGVEHFGCMVDLLSKAGLLEDALFLIRSMKLEPNSVIWGALLGGCKLHKNLEIAQVAVDELMVLEPYNSGYYTLLVNMYAEVNRWGQVAKIRQMMRELGVGKRCPGSSWIEMENEIHQFSASDKSHLASDEIYSILAELDVQLKRAGYLPALVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2MZV6</accession>
    <name>A0A0D2MZV6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_004G176300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB25087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2MZV6"/>
    <dbReference type="STRING" id="29730.A0A0D2MZV6"/>
    <dbReference type="Gramene" id="KJB25087">
        <property type="protein sequence ID" value="KJB25087"/>
        <property type="gene ID" value="B456_004G176300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZPA">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="ADWIWAR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36780">
        <property type="entry name" value="OS05G0241400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36780:SF1">
        <property type="entry name" value="PROFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB25087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="20704" checksum="BC5766697432D906" modified="2015-04-29" version="1">MDWAFVQKSWEKWASSNIGSSGNLSHSFHYTLFYLLICDWGLHCKLQAVTANLACSKIAGQPLKAALLINYDPLRPSRLLSTIAEQEGIKISPIELSQFVNFIKRNKLQKETFMIGNNQYMVTSIHENWFCARSLNTSKSAGEGAIVMQASVFLLVALYDGSIGLASRAMASVDQLVWQLNRKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N8K2</accession>
    <name>A0A0D2N8K2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G118800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N8K2"/>
    <dbReference type="STRING" id="29730.A0A0D2N8K2"/>
    <dbReference type="Gramene" id="KJB09008">
        <property type="protein sequence ID" value="KJB09008"/>
        <property type="gene ID" value="B456_001G118800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792333"/>
    <dbReference type="eggNOG" id="KOG2369">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CWLIGYL"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="691" mass="77343" checksum="C8DB752BC31CFD12" modified="2015-04-29" version="1">MASVLRFRKLCYVESAVKCTSVGYESFEIDEKLDEKEEDVLSANHFALEINKKRKQPKRQPKEWRCLDSCCWIIGYLCTTWWLLLFCYHCLPVTLLRVPELPGPGVRLKREGLTALHPVVLVPGIVTGGLELWEGRPCADGLFRKRLWGGGSFTQIFKRPLCLLEHLSLHYETGLDPQGIRVRAVPGLVGADYFAPGYFVWAVLIENLAKIGYEGKNLHMAAYDWRLSFQNTEIRDHALTRLKSKIELMYISNGYKKVVAVPHSMGVIYFLHFLKWVETPPPMGGGGGPGWCAKHIKAVMNIGPAFLGVPKAVSNLFSAEGKDVSYIRAMAPGVFDSEILGLQTFERVMRMARTWDSIVSLLPKGGEVIWGNMDRSPEEGHVCDFSKKSHSKTSLTTNNINNSDVKRGFLVKDLANYGRIISFGKPASVLHSSKLPTADSKEFSRTSTSENFNNFSCGEAWTEYDEMSRQSIQNVAADKAYTTTTLLDLLRFVAPKMMRRAEAHFSHGIAENLDDPKYNHYKYWSNPLETKLSDAPDMEIYCMYGVGIPTERSYVYKLSPNSRCKSIPYQIDNSVHGEDGSCLKGGVYFADGDESVPVLSAGFMCAKGWRGRTRFNPSGIATYIREYRHKPPTSLMEGRGIESGSHVDIMGNFALIEDIMRVAAGATGDEIGGDQIHSDIIKMSERINLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2N9K7</accession>
    <name>A0A0D2N9K7_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G143700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2N9K7"/>
    <dbReference type="STRING" id="29730.A0A0D2N9K7"/>
    <dbReference type="Gramene" id="KJB09458">
        <property type="protein sequence ID" value="KJB09458"/>
        <property type="gene ID" value="B456_001G143700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105794779"/>
    <dbReference type="eggNOG" id="ENOG502S304">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTPHWLF"/>
    <dbReference type="OrthoDB" id="1921976at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025322">
        <property type="entry name" value="PADRE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33052">
        <property type="entry name" value="DUF4228 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14009">
        <property type="entry name" value="PADRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="199" mass="22363" checksum="BCCA2784298DC55C" modified="2015-04-29" version="1">MGNYVTALACPPSDTAGKVILWDGAVQDFSWPLTAAELMLEHPQQVVVEFHEAVNQKRPVPLPADHKLDVKKVYVMLPVKRGKPTTLSSEEARRVLSSASSVLRSKSVSPSSKFLPLFARICPANDVLEMAQKLPLQKKENGGEKPEEVQCLTEFLMETVEGRPEFLNRQYSGKGWKPSLDTIKEKKVERKVKVPHWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2ND15</accession>
    <name>A0A0D2ND15_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G230000</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2ND15"/>
    <dbReference type="STRING" id="29730.A0A0D2ND15"/>
    <dbReference type="Gramene" id="KJB10873">
        <property type="protein sequence ID" value="KJB10873"/>
        <property type="gene ID" value="B456_001G230000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105804328"/>
    <dbReference type="eggNOG" id="ENOG502QRSF">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QGRSKFV"/>
    <dbReference type="OrthoDB" id="1928604at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18919">
        <property type="entry name" value="bHLH_AtBPE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000002">
        <property type="entry name" value="Basic helix-loop-helix transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024097">
        <property type="entry name" value="bHLH_ZIP_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565:SF184">
        <property type="entry name" value="BHLH TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12565">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="160"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="308" mass="34482" checksum="EA14EFDA6A7A5BBF" modified="2015-04-29" version="1">MDNQFSLNAPPFHLEPSLSASYYLSSAMDIHATELNCSQHCEQPTDYYGLHFHLPLSSMPSQVGGFQGNNNNISPLQGRSKSVTSQNESLLNPNADLEASKYWNSRKRTKTVETSASPTIAAKGSERNQESNEKRSNTNTNTKPLEPPKDYIHVRARRGEATDSHSLAERVRREKISERMKLLQDLVPGCNKVIGKAVMLDEIIKYVQSLQRQVEFLSMKLASVNSRLDFKLDSVMSEDIFQSNNNFAHPISTIDSWASAIFGQQQQNLALHSNVSNGTMTQCSVQPMDTAIWPQLQHPFTSNQLPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NEY3</accession>
    <name>A0A0D2NEY3_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_001G271100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NEY3"/>
    <dbReference type="STRING" id="29730.A0A0D2NEY3"/>
    <dbReference type="MEROPS" id="M48.021"/>
    <dbReference type="Gramene" id="KJB11678">
        <property type="protein sequence ID" value="KJB11678"/>
        <property type="gene ID" value="B456_001G271100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769614"/>
    <dbReference type="eggNOG" id="ENOG502QUG6">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07325">
        <property type="entry name" value="M48_Ste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000007">
        <property type="entry name" value="Peptidase M48 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M48" evidence="7">
        <location>
            <begin position="126"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="342" mass="37723" checksum="C28517406C881A5A" modified="2015-04-29" version="1">MASLVLSSLCFTSQKPCSFTSSLRFSLGALTGSRSAAPLTVGFRPVKRRNGRIRVSVYSRASPLVFRDLDADDFRHPLDKQNTLILKAIPGLNELGRALLAGTVTEQIMLLENIGTSVLVSKDQLPELHKMMIEAAGILNIESPDLYVRQSPVPNAYTLAISGKKPFVVIHTSLVELLTRNELQAVLAHELGHLKCDHGVWLTFANLLTLGAYSVPGLGAFLAQTLEEQLFRWLRAAELTCDRAALLVAQDPKVVISVLMKLAGGCPSMADQLNVDAFLEQARSYDKASSSPVGYYIRNAQTRQLSHPLPVLRAREIDEWSRSNEYRSLLKRATQMNVVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NF84</accession>
    <name>A0A0D2NF84_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb/SANT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G1085002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NF84"/>
    <dbReference type="STRING" id="29730.A0A0D2NF84"/>
    <dbReference type="Gramene" id="KJB11808">
        <property type="protein sequence ID" value="KJB11808"/>
        <property type="gene ID" value="B456_002G1085002"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S2HS">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="CQHELID"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48464">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48464:SF1">
        <property type="entry name" value="MYB_SANT-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34649" checksum="78B8D1BD76138C2F" modified="2015-04-29" version="1">MSGVPQSHASSQASRGTKRKWVPEEDAALVSCMVDLHNLGTFNADTGFKAGYLNELEKMLEKALPNAILKAKPNIESRISGFGWDEHRQLVVAEDAVWDSYLKSHKEAAQFRHRTFPYYDQLTAIYARDRATGKDAQTAADVLEEINAEDVPTTDMNEERNTFYDCEANVSLDDMNIFGTEPRGDRDQGGSSSSNKKKKKSDARDNMSSSFNEASTLLAENVRAIGDQISRSIASDVVVQQKSEEFQIIQEKATNLYSTLWETEGLTDDERYRALSKIPDHPTQMLVFFSLPYAARMEWVRRFLSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2NGT1</accession>
    <name>A0A0D2NGT1_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_002G016800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2NGT1"/>
    <dbReference type="SMR" id="A0A0D2NGT1"/>
    <dbReference type="Gramene" id="KJB12418">
        <property type="protein sequence ID" value="KJB12418"/>
        <property type="gene ID" value="B456_002G016800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105774006"/>
    <dbReference type="eggNOG" id="KOG0048">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MENQPNK"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000001">
        <property type="entry name" value="MYB-related transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015495">
        <property type="entry name" value="Myb_TF_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641">
        <property type="entry name" value="MYB FAMILY TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10641:SF1418">
        <property type="entry name" value="MYB-RELATED TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
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                <person name="Gundlach H."/>
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                <person name="Jin D."/>
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                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
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                <person name="Romanel E."/>
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                <person name="Wang Z."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Frelichowski J.E."/>
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                <person name="Scheffler J.A."/>
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                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
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                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A0D2PQI3"/>
    <dbReference type="STRING" id="29730.A0A0D2PQI3"/>
    <dbReference type="Gramene" id="KJB06236">
        <property type="protein sequence ID" value="KJB06236"/>
        <property type="gene ID" value="B456_001G137300"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502S9T7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MENDRYY"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485">
        <property type="entry name" value="OS01G0939000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36485:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB06236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9691" checksum="A818F94F1081A9B5" modified="2015-04-29" version="1">MVISGDGSSRSKTTMWGWLLVGIGSLVLLGFLFTAFISHLLPPSNYTLIAVIQNDRYYCFLVPLTLPVVVVAVYFHWLSMKLFRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PQJ9</accession>
    <name>A0A0D2PQJ9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Axial regulator YABBY 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_001G127000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YABBY family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PQJ9"/>
    <dbReference type="SMR" id="A0A0D2PQJ9"/>
    <dbReference type="STRING" id="29730.A0A0D2PQJ9"/>
    <dbReference type="Gramene" id="KJB09159">
        <property type="protein sequence ID" value="KJB09159"/>
        <property type="gene ID" value="B456_001G127000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793166"/>
    <dbReference type="eggNOG" id="ENOG502R9GD">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HEAPRMP"/>
    <dbReference type="OrthoDB" id="667577at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010158">
        <property type="term" value="P:abaxial cell fate specification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000047">
        <property type="entry name" value="Axial regulator YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006780">
        <property type="entry name" value="YABBY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056775">
        <property type="entry name" value="YABBY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056776">
        <property type="entry name" value="YABBY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675:SF30">
        <property type="entry name" value="AXIAL REGULATOR YABBY 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31675">
        <property type="entry name" value="PROTEIN YABBY 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04690">
        <property type="entry name" value="YABBY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24868">
        <property type="entry name" value="YABBY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="YABBY N-terminal" evidence="8">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="YABBY protein C-terminal" evidence="7">
        <location>
            <begin position="97"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB09159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="20437" checksum="FB408C753526AB3A" modified="2015-04-29" version="1">MSMDLTSERVWYVHCNFCNTILAVSVPCNSAFNIVTVRCGHCANLLSVNMGTSLQTVPSQDAQKQQITIDEDHSNKECGSSSKCNKFSAVDSTEQEATRMPPIRPPEKRQRVPSAYNRFIKEEIQRIKASNPDISHREAFSTAAKNWAHFPHIHFGLKLDGSKQAKLDQGYADQGSQKSNGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PR31</accession>
    <name>A0A0D2PR31_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_008G083900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB48737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PR31"/>
    <dbReference type="STRING" id="29730.A0A0D2PR31"/>
    <dbReference type="Gramene" id="KJB48737">
        <property type="protein sequence ID" value="KJB48737"/>
        <property type="gene ID" value="B456_008G083900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2256">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QMFFPIP"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF8">
        <property type="entry name" value="PROTEIN REBELOTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="73"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="682"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB48737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="84088" checksum="600BE7820CFA2EA9" modified="2015-04-29" version="1">MGKLGKKARKFAKKNLQSVLKRKRQLKSMFKKKASKRDEKDEAENLEEDQIGKSSGRDLECENIEDIELDAVFSDESDVVEDDSESDGYLSEGSSCPYPDENGTESDLDEDMDVDNGGAIELLEQNRAICIELTEKKKKLERLQKKDPEFSKFLESYENGLGKLRDDENYSDEDNTSEDGTESPEKGTVNLRKGKLLTSSAFNLLCQLVREHRSISALTSLLNEYRAACHYGSEPSDLHDVALCSGLQDSKTFSKILIFMLQEADNIFREMLGISSSSCKKEAILELKNSSKWKTMKPLIKSYLRSTLFLLNQVTNSEILAFSLVRVRASVIFFATFHPLLRRLIKIAVHLWVTGEGTLALHSFLVIKDVASVFSSDCFNSCLIKTYKAFITHCKFVDPVSSKHIQFLHNSFIELCSLDVQNSSRKAMVCVEQLSKILQTGLKTKKKEAVKRICSRQSTNCINLWVSFISANVKDYDLQPLLYMIIQIINGVAVLFPGPRYLPLRIKCIQWLNNLSSASGVFIPVASFAMDILEYKTGKDNGKPGKDFNFSSTIKLPKHWLKSRKFQDKCVSSVIELLATHFAQWSCHITFPELATIPLICLRKFLETTTIERFQRMVKRFVDQVEQNIEFMQRKRDEVAFSPKDHQIVDSFLQFEKSNANASFTQYYKSIIEKAASSKPVMNQKIRTCSSSSQKKPKRKERQLPNNTVRLNAIDEVVEEKKKSTDNGAGGKMRKKRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PS60</accession>
    <name>A0A0D2PS60_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">B456_001G016600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB06861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PS60"/>
    <dbReference type="STRING" id="29730.A0A0D2PS60"/>
    <dbReference type="Gramene" id="KJB06861">
        <property type="protein sequence ID" value="KJB06861"/>
        <property type="gene ID" value="B456_001G016600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0118">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12614">
        <property type="entry name" value="RRM1_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000256">
        <property type="entry name" value="oligouridylate-binding protein 1-like isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000191">
        <property type="entry name" value="Oligouridylate-binding protein 1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF20">
        <property type="entry name" value="TIA1 CYTOTOXIC GRANULE ASSOCIATED RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="48"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="133"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="249"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="KJB06861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="400" mass="43429" checksum="5A17A7DFF826F4CB" modified="2015-04-29" version="1">MQQQGLNPQQQAMMQQALYHHPSLFAGPQIEPILSGNLPPNFDSATCRSVYVGNIHPQVSEPLLQEVFLSTGPIEGCKLIKKDKSSYGFVHYFDRGSAALAIVTLNGRHLFGQPIKVNWAYASSQREDTSTHHNIFVGDLSPEVTDATLFACFSVYSSCSDARVMWDQKTGRSRGFGFVSFRNQQDAQSAINDLNGKWLGSRQIRCNWAAKGATSNDDNAKSIVDSNGPSEEGQEKSNDDSPENNPMYTTVYVGNLAPEVTSADLHSHFHALGAGTIEDVRVQRDKGFGFVRYSSHDEAALAIQMGNARILCSKPIKCSWGSKPTALGTSSGPHPPPTAAHMAGGAQVMNMMHPQGQYAVKAQAAMGMSGGEASQAMYNGGYQNVATSQQQLMYYHLQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PSG0</accession>
    <name>A0A0D2PSG0_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_001G165700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2PSG0"/>
    <dbReference type="Gramene" id="KJB09784">
        <property type="protein sequence ID" value="KJB09784"/>
        <property type="gene ID" value="B456_001G165700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB09784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="134" mass="15245" checksum="450947A3A0A6717F" modified="2015-04-29" version="1">MSRPFFMRIHIHSQTQRCTIRPKSWLANANREGRTNGLGVDWFRADSWSCCLDYRRIRGVPPLRGEGVTCLVLRCTHSRYENEMTPQLDSRPRLLTTRTNSGAERHLPTRARSSIGGQECGPAEKQKSSVSSNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2PYV4</accession>
    <name>A0A0D2PYV4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_002G009300</name>
        <name evidence="11" type="ORF">Gorai_022065</name>
    </gene>
    <organism evidence="10 12">
        <name type="scientific">Gossypium raimondii</name>
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            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
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    <reference evidence="10 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="11 13" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">8</strain>
            <tissue evidence="11">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="11" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
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            <strain evidence="11">8</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
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<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
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    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
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                <person name="Mansoor S."/>
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                <person name="Walford S.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
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            <name>Mg(2+)</name>
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        </cofactor>
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        <text evidence="2 9">Lipid metabolism; fatty acid metabolism.</text>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045311">
        <property type="entry name" value="LC-FACS_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF6">
        <property type="entry name" value="LONG CHAIN ACYL-COA SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="10">
        <location>
            <begin position="71"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU369030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB09486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="667" mass="75249" checksum="AB0381A9FC4391D5" modified="2015-04-29" version="1">MENRKVFSVKVEDGREGRDGKPSVGPVYRNLLAKQGYPPPDPEMSTTWTLFRWIFCSSSVEKYPGNRMLGWRKFVDGKVGPYIWKTYKEVYDEVLHVGSALRASGVEPGCRVGIYGANCPQWIMAMEACGAHSLVCVPLYDTLGSGAVNFIIDHAEVDFVFVQDIKVKELLNPNCKSTQQLKAIVCFTSLAEEDNAKASQMGIKTYSWTEFLHMGKENPWEISPPQPFSICTIMYTSGTSGDPKGVVLTHETMATFVCGVDLFLDQFEDKMTVDDVYLSFLPLAHILDRMIEEYFFHRGASVGYYHGNLKELRDDIMELKPTFLAGVPRVYDMIHEGIQQALQELSPLRKWIFDALYKHKLSWMNKGYKQKFASPLADLLAFRKVKAKLGGRLRLLLSGGAPLSSEVEEFLRVTCCAFVVQGYGLTETCGACTIGFPDEMCFVGAVGSPAVYNDLRLEEVSDMGYDPLGNPPCGEICVKGKTIFSEYYKNPELTRESFEDGWFHTGDIGQMLPNGIFKVIDRKKNLIKLSQGEYVALEYLENVYGVTPIIDDVWVYGNSFKSMLVAVVVLHEENAKKWAELNGYTVSLSELCSLSKLQNYVLSELKSTADKNKMRGFEYIKGVILEARAFDMERDLVTATLKKKRNNLLKYYQAEIDALYHNLTTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q524</accession>
    <name>A0A0D2Q524_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">B456_001G0222002</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB11788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q524"/>
    <dbReference type="STRING" id="29730.A0A0D2Q524"/>
    <dbReference type="MEROPS" id="M41.018"/>
    <dbReference type="Gramene" id="KJB11786">
        <property type="protein sequence ID" value="KJB11786"/>
        <property type="gene ID" value="B456_001G0222002"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB11788">
        <property type="protein sequence ID" value="KJB11788"/>
        <property type="gene ID" value="B456_001G0222002"/>
    </dbReference>
    <dbReference type="OMA" id="HETMTAD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045037">
        <property type="term" value="P:protein import into chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF37">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="91"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="KJB11786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="550" mass="59424" checksum="9DED8AD497A37D8B" modified="2015-04-29" version="1">MVSSESGNFKDQLWRIFRSLALGFLLISGIGALIEDRGISKGLGLHEEVQVVESNTKFNDVKGVDEAKAELEEIVHYLQDPKRFTRLGGKLPKGVLLVGPPGTGKTMLARAIAGEAGVPFFSCSGSEFEEMFVGVGARRVRDLFSAAKKRSPCIIFIDEIDAIGGRRNPKDQQYMRMTLNQLLVELDGFKQNEGVIVIAATNFPESLDKALVRPGRVDRHIIVPYPDVEGRRQIMESHMSKVLKAEDVDLMIIARGTPGFSGADLANLVNIAAVKAAMDGAKAVTMTDLEFAKDKIILGSERKSAVISEESLKLTAFHEAGHALVAIHTNGALPVHKATIVPRGSSLGMVSQLPDKDQTSFSRKQMLARLDVAMGGRVAEELIFGENEVTSGAVSDLENATNLARKMVTRYGMSKEVGLVTHFYNDHGRSMSTETRLLIEKEVRELLERAYNNAKTILTTHCKEHYALANALLEHETLTGSQIKAMLAQFNSQQQQEQCEQRIEPQNGSKFNPVPSSASPATSAAAAAAATATATATAAAKGKGVAPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2Q5K6</accession>
    <name>A0A0D2Q5K6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_002G056700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB11986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2Q5K6"/>
    <dbReference type="STRING" id="29730.A0A0D2Q5K6"/>
    <dbReference type="Gramene" id="KJB11986">
        <property type="protein sequence ID" value="KJB11986"/>
        <property type="gene ID" value="B456_002G056700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QSS7">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF4">
        <property type="entry name" value="POTASSIUM TRANSPORTER 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB11986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="167" mass="19075" checksum="C0CBFB30681A8A39" modified="2015-04-29" version="1">MDFVKTALFKRHSNYSISVDEISMKLDFIWAPYVLNLTHLLKGFKTKKKYPDVMVMRAGLWHMLHVSNPSNYELVLQTLKSSLVSLFPFSTDIANAYGIAEVVVMLVTTTLVTLVMLLICVLKNSLFLKKLVINYFYAFLRRNCRVGAANMSVPHMNILQVGMAYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QAK2</accession>
    <name>A0A0D2QAK2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">B456_002G226700</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="13">May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Acts redundantly with BOP2. BOP1/2 promote leaf and floral meristem fate and determinacy in a pathway targeting AP1 and AGL24. BOP1/2 act as transcriptional co-regulators through direct interaction with TGA factors, including PAN, a direct regulator of AP1. Controls lateral organ fate through positive regulation of adaxial-abaxial polarity genes ATHB-14/PHB, YAB1/FIL and YAB3, and through positive regulation of LOB domain-containing genes LOB, LBD6/AS2 and LBD36. Promotes and maintains a developmentally determinate state in leaf cells through the negative regulation of JAG, JGL and class I KNOX genes. Is also involved in nectary development, formation of normal abscission zones (AZs) and suppression of bract formation, probably by regulating the cell wall disorganization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the plant 'ANKYRIN-BTB/POZ' family. 'NOOT-BOP-COCH-like' (NBCL) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001741">
        <property type="protein sequence ID" value="KJB16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QAK2"/>
    <dbReference type="STRING" id="29730.A0A0D2QAK2"/>
    <dbReference type="Gramene" id="KJB16374">
        <property type="protein sequence ID" value="KJB16374"/>
        <property type="gene ID" value="B456_002G226700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105786203"/>
    <dbReference type="eggNOG" id="KOG0504">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RMKDEHT"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010434">
        <property type="term" value="P:bract formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010582">
        <property type="term" value="P:floral meristem determinacy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010227">
        <property type="term" value="P:floral organ abscission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048439">
        <property type="term" value="P:flower morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009864">
        <property type="term" value="P:induced systemic resistance, jasmonic acid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009944">
        <property type="term" value="P:polarity specification of adaxial/abaxial axis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009954">
        <property type="term" value="P:proximal/distal pattern formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18310">
        <property type="entry name" value="BTB_POZ_NPR_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000084">
        <property type="entry name" value="regulatory protein NPR5 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000058">
        <property type="entry name" value="regulatory protein NPR5 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044284">
        <property type="entry name" value="NPR5/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024228">
        <property type="entry name" value="NPR_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057250">
        <property type="entry name" value="Znf_C2HC_NPR-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46668">
        <property type="entry name" value="BTB/POZ DOMAIN AND ANKYRIN REPEAT-CONTAINING PROTEIN NH5.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46668:SF1">
        <property type="entry name" value="REGULATORY PROTEIN NPR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11900">
        <property type="entry name" value="DUF3420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52046">
        <property type="entry name" value="ZF_C2HC_NPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BTB" evidence="17">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="C2HC NPR-type" evidence="18">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="14">
        <location>
            <begin position="323"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="406"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="455"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="KJB16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="53724" checksum="38C14F421896AE51" modified="2015-04-29" version="1">MSSLDESLRSLSLDYLNLLINGQAFSDVTFSVEGRLVHAHRCILAARSLFFRKFFCGPDPPAGLDPVGSRMNRGGGSTAGSRPGVIPVNSVGYEVFLLLLQFLYSGQVSIVPQKHEARPNCSERACWHTHCTSAVDLALDTLAAARYFGVEQLALLTQKQLASMVEKASIEDVMKVLIASRKQDMHQLWTTCSHLVAKSGLPPEVLAKHLPIDVVAKIEELRLKSSLTRRSLIPHHHHHHHHHPHPHHDLTAAADLEDQKIRRMRRALDSSDVELVKLMVMGEGLNLDEALALHYAVENCSREVVKTLLELGAADVNYPAGPAGKTPLHIAAEMVSPDMVAVLLDHHADPNVRTVDGVTPLDILRTLTSDFLFKGAVPGLTHIEPNKLRLCLELVQSAAMVISREEGSVNPPTSTAIYPPMSDEHNSSSSGNNLANLNLDSRLVYLNLGATASTQMGSRMEGDDDSSHNSQREAMNRHDPTMYHHSHDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QDR1</accession>
    <name>A0A0D2QDR1_GOSRA</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G113700</name>
        <name evidence="4" type="ORF">Gorai_011625</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Viridiplantae</taxon>
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            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
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            <taxon>malvids</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
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                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">8</strain>
            <tissue evidence="4">Leaf</tissue>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
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        <property type="protein sequence ID" value="KJB56267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="MBA0594731.1"/>
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        <property type="gene ID" value="B456_009G113700"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG0725">
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    </dbReference>
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        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="PRK07231.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF95">
        <property type="entry name" value="OS07G0691600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB56267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="MBA0594731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="299" mass="31888" checksum="4572E848DB20B12C" modified="2015-04-29" version="1">MPAQVTPQKMIQGVDLVDKNTTTQLLSLRRLEEKVAIITGGARGIGEATVRVFVKHGAKAVIADIADAAGIALANSLAPSAVYVHCDVSSEEDVEMLINRTISLYGKLDILVNNAGVLGNQSKRKSIIDFDAGEFDRVMQVNVRGVALGMKHAAKVMMPRRSGCIISMASVAGCMGGLGPHAYTASKHAIIGLTKNTACELGQYGIRVNCISPFGVATSMLINAWRSSDQVDHEECTDLEAEEMEEFVRGLANLKGVTLKAKDVAEAALYMASEESRYISGHNLVVDGGFTSFKNCVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QHI6</accession>
    <name>A0A0D2QHI6_GOSRA</name>
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        <recommendedName>
            <fullName evidence="4">Cell growth-regulating nucleolar protein-like winged helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_003G0856002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
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        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
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            <taxon>malvids</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QHI6"/>
    <dbReference type="STRING" id="29730.A0A0D2QHI6"/>
    <dbReference type="Gramene" id="KJB19119">
        <property type="protein sequence ID" value="KJB19119"/>
        <property type="gene ID" value="B456_003G0856002"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2809">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058719">
        <property type="entry name" value="WHD_LYAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149:SF9">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25879">
        <property type="entry name" value="WHD_LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell growth-regulating nucleolar protein-like winged helix" evidence="4">
        <location>
            <begin position="241"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="31"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB19119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="316" mass="35405" checksum="62E0CBF8545D5C66" modified="2015-04-29" version="1" fragment="single">GIGLDKPNPWAFDTAQFDSILKGLKVKQAVQTNDEAEKNENQVETKSDEPNDTEEQVVKATRPQGRYKKRERGKLVHAYSSRDLEGILAKKVEESLQVNPDVVGEMEIIETTETNDFSTEGNKVESVSPEWWGFKYGFVSGGFLGETTRRKSIKTGESKNSTERTVFYEDDQENLYKLVQDKATTGKQGLGIKDRPKKVAGVHFQGKKTSFSDSDGEDSDDVGPPAKRMRENALETEKADEPKLRLKKLCKRLLRQVPGDSLKLKQLKVLIDEQSTLVFSSFSSKKDAIAYLKRKLEGSSKFSVEGKRVSLTSRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJU2</accession>
    <name>A0A0D2QJU2_GOSRA</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_003G1262002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB19964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="8" mass="932" checksum="FA24004411A87DD6" modified="2015-04-29" version="1" fragment="single">MAGTRIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QJX8</accession>
    <name>A0A0D2QJX8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Uroporphyrinogen-III synthase</fullName>
            <ecNumber evidence="3 7">4.2.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_009G209500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>hydroxymethylbilane = uroporphyrinogen III + H2O</text>
            <dbReference type="Rhea" id="RHEA:18965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="EC" id="4.2.1.75"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uroporphyrinogen-III synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.75" evidence="3 7"/>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QJX8"/>
    <dbReference type="STRING" id="29730.A0A0D2QJX8"/>
    <dbReference type="Gramene" id="KJB58397">
        <property type="protein sequence ID" value="KJB58397"/>
        <property type="gene ID" value="B456_009G209500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105769179"/>
    <dbReference type="eggNOG" id="ENOG502QST9">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="WVESIME"/>
    <dbReference type="OrthoDB" id="443551at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10090:FF:000009">
        <property type="entry name" value="Uroporphyrinogen-III synthase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38042:SF1">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="9">
        <location>
            <begin position="69"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="305" mass="32506" checksum="978EC454C26E77FE" modified="2015-04-29" version="1">MALLSLSSLSPLAPPCPSFPLQLQTRISFSRARIGASSTSSPSTSQVIQHASSNPKVVVTRERGKNTKLIDALAEHGINCLELPLIQHLQGPDSDRLASVLSAETAFDWIVITSPEAGSVFLEAWKAAGTPNVRIGVVGAGTASIFENLKQPSKQSLHVAFAPSKATGKVLASELPMDGNKRCTVLYPASVKASNEIEEGLSHRGFQVLRLNTYTTVPVDHVDHIVLEKAQSAPVVTVASPSAVRSWVNLISEPDSWSNAVACIGETTASAAKRLGLRNVYFPMQPGLDGWVGSILEALRAHDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QLH8</accession>
    <name>A0A0D2QLH8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_003G011600</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
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            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="29730.A0A0D2QLH8"/>
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        <property type="gene ID" value="B456_003G011600"/>
    </dbReference>
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    <dbReference type="eggNOG" id="KOG2456">
        <property type="taxonomic scope" value="Eukaryota"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF17">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE FAMILY 3 MEMBER F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 7">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB17706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="53260" checksum="6F46067514C08728" modified="2015-04-29" version="1">MEKSIAELRETFKTGGTKSISWRKSQLKALLQLINQNEDSIFKALDQDLGKSPVESYRDEVGVLKKSVTYTLSCLEKWVAPKKAEVPLLFFPAKAEVMPQPLGVVLIFSSWNFPFTLALDPLIGAISAGNTVLLKPSDLAPACMSFLVETIPKYLDNKAVKVLAGGADIGERLLQLKWDKIFFTGSPRVGRLVMAAAAKHLTPVTLELGGKSPAIVDTLSTTPSKAKVTAKRIVGGKWGPCTGQACIAIDYVLVEEKLASTLIELLKKTIKRFYGENIKSLKNISRIVNKHQFQRLVNLLKDPDVADSIVYGGSVDEEKLVIEPTILLDPPLDSEIMSEEIFGPLLPIITLKNVEESIDFINSKSNPLVIYAFTEDETFKKRILSETSSGTVTFNDSMVQFLCDSLPFGGVGQSGFGRYHGKYSFDTFSHEKSILHRGFYPEIEPRYPPWTDFKLLFLKLAYQFDYFGLILLLLGFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QNI2</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
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        <lineage>
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            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="B456_003G051600"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
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        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB18411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="87" mass="10167" checksum="9974F9C09D553E49" modified="2015-04-29" version="1">MGETRPVPRRESPWGMPEGEHRQPKAHRCNDRAEDVIQACFEGNPFKTVPGPFKLFWQCMRSKPGEEPTEPYTYLQLDPPKREVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QPV6</accession>
    <name>A0A0D2QPV6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutaredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_003G077600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
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        <lineage>
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            <taxon>Pentapetalae</taxon>
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            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
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    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
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                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
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                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB18961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QPV6"/>
    <dbReference type="STRING" id="29730.A0A0D2QPV6"/>
    <dbReference type="Gramene" id="KJB18961">
        <property type="protein sequence ID" value="KJB18961"/>
        <property type="gene ID" value="B456_003G077600"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG2824">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd03031">
        <property type="entry name" value="GRX_GRX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45669:SF22">
        <property type="entry name" value="GLUTAREDOXIN DOMAIN-CONTAINING CYSTEINE-RICH PROTEIN CG12206-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23733">
        <property type="entry name" value="GRXCR1-2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB18961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="353" mass="38289" checksum="9CAECC6CC98304BE" modified="2015-04-29" version="1">MGCVSSNLLNRDDEFTQLGSSAFGNHIVSLTSTTYGLLTLDPPSHSTTTPPSPQPSFTSGSTFSESKSLWSEPRPVPTRPEVINSWELMSGLDADSFRFSPIPNKENSNPNVGKNGSVSKPPVSRSSLLDKFQADSFRFPITVLPEKENADPNLSKNGIVAKTPFSPLHKFDSGSDAVSKPSPLDKFENICPPNGENRVVIYTTTLRGIRKTFEDCNAVRSTIESYGVVICERDISMDRGFKEELRELMKGANQTTPPQVFIKGRYIGGAEQVMKIVDECWFGDLINGLPKKKAGEVCDGCGDVKFLPCFRCNGSCKMAAAAEEGRRTVVVRCTDCNENGDELGGAAIGIGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QR17</accession>
    <name>A0A0D2QR17_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Terpene synthase metal-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_009G306700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QR17"/>
    <dbReference type="STRING" id="29730.A0A0D2QR17"/>
    <dbReference type="Gramene" id="KJB60472">
        <property type="protein sequence ID" value="KJB60472"/>
        <property type="gene ID" value="B456_009G306700"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502QUH3">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VTEDCAR"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050148">
        <property type="entry name" value="Terpene_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005630">
        <property type="entry name" value="Terpene_synthase_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225">
        <property type="entry name" value="OS04G0344100 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31225:SF98">
        <property type="entry name" value="TERPENE SYNTHASE 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03936">
        <property type="entry name" value="Terpene_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Terpene synthase metal-binding" evidence="4">
        <location>
            <begin position="13"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="KJB60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="217" mass="24605" checksum="28D6F35D07C208C7" modified="2015-04-29" version="1">MKLHSWQYKAKKILEEAKAFSSENLKNVIGKLEKVEAKQWDILCRAHITEARWFYGGQIPTFDEYIKNAWISIGSLGGLVLVCFVEADSIVHQFPNCLKDSQLFYRPSLITRLSNDLGTSKAEMERKDIPKAVQSYTIEKGVSEEKARNHVKELISNSWKKINEEILDSRFSRVIVNLSKNMARTAQCIYQHGDGVGTSTGVTKDCIVSSILRPIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QR44</accession>
    <name>A0A0D2QR44_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_001G157700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001740">
        <property type="protein sequence ID" value="KJB09685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QR44"/>
    <dbReference type="Gramene" id="KJB09685">
        <property type="protein sequence ID" value="KJB09685"/>
        <property type="gene ID" value="B456_001G157700"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB09685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="131" mass="14840" checksum="09FF2E4C04711871" modified="2015-04-29" version="1">MMFTFQMMFKLMETIKKEKNPEISSSHFKTGRKKSSKQIGGAARLSSQIEKLCNAADNMSQATSSLTPVMDPYGILQAVKVLDSMLGEVPKASPLYFFALKLLLNKDKRIMFLSINPKIRVLWLKTEMEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QV65</accession>
    <name>A0A0D2QV65_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G392100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QV65"/>
    <dbReference type="STRING" id="29730.A0A0D2QV65"/>
    <dbReference type="Gramene" id="KJB61927">
        <property type="protein sequence ID" value="KJB61927"/>
        <property type="gene ID" value="B456_009G392100"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG4548">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FMGVRGF"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB61927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="205" mass="23617" checksum="11921E58B24CB341" modified="2015-04-29" version="1">MHRSLVRPFMGVRGFSSTSKKIVASVLFERLPVVIPKLDPVVYAFKSFRKGKGDYQIDNVPAPRITEADKTIDRKSLQRALDRRLYLLPYGNSNAAPSGKPVWHFPEKVYDSEETLRKCAESALAFVLGDLSHTYFVGNAPMGHMVIRQMENVPEPFKRFFFKSQVIDTNKFDIQKCEDFVWVTKGELLEYFPEQAEFFKKLIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2QXN2</accession>
    <name>A0A0D2QXN2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_009G430900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class VIII subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB62697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2QXN2"/>
    <dbReference type="STRING" id="29730.A0A0D2QXN2"/>
    <dbReference type="Gramene" id="KJB62696">
        <property type="protein sequence ID" value="KJB62696"/>
        <property type="gene ID" value="B456_009G430900"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB62697">
        <property type="protein sequence ID" value="KJB62697"/>
        <property type="gene ID" value="B456_009G430900"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105768319"/>
    <dbReference type="eggNOG" id="KOG0160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="MQAISTH"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01383">
        <property type="entry name" value="MYSc_Myo8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000013">
        <property type="entry name" value="Unconventional myosin-XIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057535">
        <property type="entry name" value="MYO1-3_N_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036022">
        <property type="entry name" value="MYSc_Myo8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25369">
        <property type="entry name" value="SH3_VIII-1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 10" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="14">
        <location>
            <begin position="142"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="13">
        <location>
            <begin position="195"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="10">
        <location>
            <begin position="741"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1178"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1111"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="286"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00060862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="KJB62697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1201" mass="135408" checksum="C886235D0F4911C5" modified="2015-04-29" version="1">MMLSVSPMAPAKSSLEEMLESLRRQGEVDKPKDLPPALPVRPTSKARLPSARRSLPTNFKIDANGVDGAVLSEVKGKEEVKRNEKELGVKIVSFGSKKMRKDVKVDSPYNLDAVEEKKGEYLEGKIEVKGGKGNANIGYFINKKLHVWCRLANGMWGSGTIQSTSGEESIVSLSNGNVIKVSTSQLLPANPGILEGVNDLIQLSYLNEPSVLHNLKRRYSHDMIYSKAGPVLIAVNPFKDVQIYGKDFVTSYREKATDSPHVFAIADNAYNEMMNDGLNQSIIISGETGAGKTETAKFAMQYLASLGGGYGGKECKILQTHCILEAFGNAKTSRNDSSSRFGKLIDIHFTALGKISGANIQTFLLEKSRVVQLAAGERSYHIFYQLCAGAPPALRERLNLKMANEYNYLVQSDCLVINGVDDCQKFQKLKEAFDIVQICKEEQEQVFAMLAAVLWLGNISFQVIDKENHVEALADEALTSVATLIGCAPHELMQAISTHRIQVGKDIIAKKLTLQQAIDTRDALAKFIYASLFDWLVEQINNSLEAGKKHIGRSISIIDIYGFESLKKNSFEQFCINYANERLQQHFNRHLFKLEQEEYDLEGIDWTKVVFEDNQECLDLFEKKPLGILSLLDEESNAPNSTDFTLANKLKQHLNSNSYFKGDRGRAFGVLHFAGEVLYDTNGFLDKNRNPLSSEVVQLLSSCDGQLPQLFAKKMFNQPLQPVTSLDTPMQSVALQFKGQLFKLMHQLESTRSHFICCIKPNSKQLPGTYEEYLVLQQLRCYGIFEVIRISRSGYPTRMTHQAFTERYGFLLSDPIVSQDPLSISVALLKQFNVLPQMYQIGYTKLFLRTGQISALEDRRKQVLRGVIEVQKYFRGHRARCLFHELNKGAKSIQSFVCGENIRRKYAAESIRCSAFASQLLDEQLTAVVYLQSVIRGWLARRHFNNMHNLKQSNRGSVKSRRKMGRKIFEAKDMLHEQQIQVLPSVMAELQRRVLKAETNLGQKEHENATLREQLQKSEARWLDYEAKMKSMEEMWQKQMVSLQTSLTAARKSLAADNGAGQLGRADVLSPRCYDSEDNVSMGSRTTGGNTPVLFSGAMPDVVGGRENGSLNALGNLLKEFEQRKQNFDADAKSLMDLRVPQQASNMNPDDELRTLRLRFETWKKDYKLRLKEAKARLHKRGHPESDKARRKWWGKLGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R537</accession>
    <name>A0A0D2R537_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_004G149000</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R537"/>
    <dbReference type="STRING" id="29730.A0A0D2R537"/>
    <dbReference type="Gramene" id="KJB24521">
        <property type="protein sequence ID" value="KJB24521"/>
        <property type="gene ID" value="B456_004G149000"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.80">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003441">
        <property type="entry name" value="NAC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036093">
        <property type="entry name" value="NAC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31989">
        <property type="entry name" value="NAC DOMAIN-CONTAINING PROTEIN 82-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02365">
        <property type="entry name" value="NAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101941">
        <property type="entry name" value="NAC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51005">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC" evidence="6">
        <location>
            <begin position="9"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB24521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="55030" checksum="37AF556E5A5DD6D8" modified="2015-04-29" version="1">MSSIDGNSHIVGYRFHPTDKELVDHYLWNKILDRDSLVQAIKEVDSLFNKDPWELPGWSKIQSADQVWYFFSRRGDNKRVKRTTDKGFWKVTGKPRKVKGKKGCAAKKSLVFYEGRTPNAKWTPWVIHEYTFTSTLLDNREGIFLCKLKKKEDETANASSSESCQPSLVADEEIPDVRCLMQSFLKSFLWTDKSIHNHSCFCMIQNSTMFNPDEMLDTLKERDREHELEVDEQQPPSCLEFTHLQDFNCDGLPHLSKEENDDESWIGYLVDDDEFNPMNLILEVDASATCPGEPSRKRSRCEAGVLCGAIEKEECQPMAVSNSMMLDAHGDSKKHQALAMVNAPNVTSSSVKQDPHGRDRMVSLNNESRELDIPDVESVVDPHSIVRATRFYNPYYQKLGEQEDDAKRINKRGKFCRKIASQDKAIDVKQHATAVNLPIIMESNGKRKTAEHSYRHMRLQMHLNELSDSDKKSFLHVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R5I7</accession>
    <name>A0A0D2R5I7_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G157700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB24716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R5I7"/>
    <dbReference type="Gramene" id="KJB24716">
        <property type="protein sequence ID" value="KJB24716"/>
        <property type="gene ID" value="B456_004G157700"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105791596"/>
    <dbReference type="eggNOG" id="KOG2458">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="VEMWEDQ"/>
    <dbReference type="OrthoDB" id="933883at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF74">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="217"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB24716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="543" mass="63704" checksum="081F8AE59A18F0FD" modified="2015-04-29" version="1">MLGIKKKYHVKQELDDDKPSIHGRMKRNNNNNQNHQTGFCLMSMLELQKPIINTPCWPVKKAAASTIIAVFLITVLMVTVGWLDISFFSGVSSYQNMVVGSKSTTARHKPEFPLECSTENQTQTCRKDYPTTTGIPPMNTSKVECPSFFRWIHEDLRHWKQTGISRDMIEGARKTAHFRLVIVKGKAYVEKYRNSIQTRDKFTLWGILQLLRMYPGRLPDLELMFDCDDRPVVRSRDFQGPNARPPPLFRYCADEWSLDIVFPDWSFWGWPETNIRPWRNVLKEIKKGNERRKWKERVPYAYWRGNPSVAPARKDLMKCNATDKNNWNTLLYVQDWDRESKQGFKHSNVEDQCSHRYKIYTEGWAWSVSEKYILACDSMTLYVRSRFYDFFIRGMLPLQHYWPISENTKCKSLKFAVEWGNLHPRKAQAIGEAAGKFIHEDLKMDNVYDYIFHLLNEYAKLLKFEPTVPPGAVELCSETMACPTTGTWKKFMVESLVMSASDVTACRMPPPYEPQELRDFLETKANSTRQVEMWEDQYWLSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2R9R2</accession>
    <name>A0A0D2R9R2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_005G055200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB28554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2R9R2"/>
    <dbReference type="STRING" id="29730.A0A0D2R9R2"/>
    <dbReference type="Gramene" id="KJB28554">
        <property type="protein sequence ID" value="KJB28554"/>
        <property type="gene ID" value="B456_005G055200"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105796789"/>
    <dbReference type="eggNOG" id="KOG0682">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HNFALRD"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097272">
        <property type="term" value="P:ammonium homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000006">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11730:SF121">
        <property type="entry name" value="AMMONIUM TRANSPORTER 1 MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="9">
        <location>
            <begin position="38"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB28554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="485" mass="52047" checksum="083817B0790CD637" modified="2015-04-29" version="1">MSTCSQDLAPLLGVNGTGAADYICGKFSDASYAVDNTYLLFSAYLVFSMQLGFAMLCAGSVRAKNTMNIMLTNVLDAATGGLFYYLFGFAFAFGSPSNGFIGRHNFALESIPSSLFDYSNFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPVVSHWFWAADGWASALRTDDFLFGSGVIDFAGSGVVHIVGGVAGLWGALIEGPRIGRFDHSGRSVALRGHSATLVVLGTFMLWFGWYGFNPGSFNKISSFYTSGNYYGQWSAVGRTAVTTTLAGCTAALTTLFGKRILTGHWNVTDVCNGLLGGFAAITSGCSVVEPWAAIICGFVAALVLIGCNKLAEKVKYDDPLEAAQLHGGCGAWGVIFTGLFASEKLVKQVYPSRPAKYGLFMGGGGKLFAAQIIQILVIVGWVSATMGTLFYFLHKFGLLRISVEDEMAGMDLTRHGGLAYVYHDEDESQKNGIQMRKIESFPTPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RGW1</accession>
    <name>A0A0D2RGW1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_008G172900</name>
        <name evidence="10" type="ORF">Gorai_009808</name>
    </gene>
    <organism evidence="9 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="10 12" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">8</strain>
            <tissue evidence="10">Leaf</tissue>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB50463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0592839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RGW1"/>
    <dbReference type="SMR" id="A0A0D2RGW1"/>
    <dbReference type="STRING" id="29730.A0A0D2RGW1"/>
    <dbReference type="Gramene" id="KJB50463">
        <property type="protein sequence ID" value="KJB50463"/>
        <property type="gene ID" value="B456_008G172900"/>
    </dbReference>
    <dbReference type="eggNOG" id="ENOG502RZ62">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FWHICIN"/>
    <dbReference type="OrthoDB" id="433124at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5033220065" description="EXPERA domain-containing protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB50463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="MBA0592839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <sequence length="166" mass="18091" checksum="8C8194E0AECEAEE6" modified="2015-04-29" version="1">MENMGVLGKVVDYLLLLSFFSITLTAQLDIPESILPHAYNPFYQVYTTLTQDYLVLEQPAFFKALMTLELVYQLPLALLNIYGLLYSKPWFNTTCLLFGASIVASTTAMVGDILNSQKASANLMAMYYPPFLPLGVLAIVRGVVGQSSKAAPSIGNGPSSAVKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RJ18</accession>
    <name>A0A0D2RJ18_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">B456_005G108100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001744">
        <property type="protein sequence ID" value="KJB29571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RJ18"/>
    <dbReference type="Gramene" id="KJB29571">
        <property type="protein sequence ID" value="KJB29571"/>
        <property type="gene ID" value="B456_005G108100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105793791"/>
    <dbReference type="eggNOG" id="KOG0254">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KWTVIIG"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000325">
        <property type="term" value="C:plant-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051119">
        <property type="term" value="F:sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17358">
        <property type="entry name" value="MFS_GLUT6_8_Class3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000043">
        <property type="entry name" value="sugar transporter ERD6-like 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044775">
        <property type="entry name" value="MFS_ERD6/Tret1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050549">
        <property type="entry name" value="MFS_Trehalose_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48021:SF23">
        <property type="entry name" value="SUGAR TRANSPORTER ERD6-LIKE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="51"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="KJB29571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="487" mass="52825" checksum="E58DD41C627049D0" modified="2015-04-29" version="1">MSFRDDSEDGRDVRKPFLHTGSWYRMGSRTGSSMLGSSQVIRDSSISVVACVLIVALGPIQFGFTNGYSSPTQSAIIKELGLTVSEYSVFGSLSNVGAMIGAVASGQMAEYIGRKGSLMIAAIPNIIGWLAISFANDVSFLYMGRLLEGFGVGIISYTVPVYIAEIAPENLRGSLGSVNQLSVTIGTMVAYLLGLFVGWRILAILGILPCTILIPGLFFIPESPRWLAKMGMTEDFEASLQVLRGFDTDISIEVNEIKRSVASTTRRTTIRFAELKKRRYWFPLMVGIGLLMLQQLGGINGVIFYSATIFETAGIKSGNIATFGVGFIQVIATALTTWLVDKTGRRLLLIVSTSGITLSLLLVALSFFLKDVVSTESSLYSIMGILSVVGVVTLVITFSLGMGPIPWIIMSEILPVSIKGLAGSIATLSNWFSAWLVTMTANLLLDWNSGGTFTIYMLVSAFTILFVSLWVPETKGRTLEEIQRSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RK31</accession>
    <name>A0A0D2RK31_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Carotenoid cleavage dioxygenase 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">B456_008G219800</name>
        <name evidence="8" type="ORF">Gorai_010165</name>
    </gene>
    <organism evidence="7 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 10" key="2">
        <citation type="journal article" date="2019" name="Genome Biol. Evol." volume="11" first="53" last="71">
            <title>Insights into the evolution of the New World diploid cottons (Gossypium, subgenus Houzingenia) based on genome sequencing.</title>
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. 2nd"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Frelichowski J.E."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
            <dbReference type="PubMed" id="30476109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2020-04" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Grover C.E."/>
                <person name="Arick M.A. II"/>
                <person name="Thrash A."/>
                <person name="Conover J.L."/>
                <person name="Sanders W.S."/>
                <person name="Peterson D.G."/>
                <person name="Scheffler J.A."/>
                <person name="Scheffler B.E."/>
                <person name="Wendel J.F."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">8</strain>
            <tissue evidence="8">Leaf</tissue>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB51508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="JABEZZ010000008">
        <property type="protein sequence ID" value="MBA0593210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RK31"/>
    <dbReference type="STRING" id="29730.A0A0D2RK31"/>
    <dbReference type="Gramene" id="KJB51508">
        <property type="protein sequence ID" value="KJB51508"/>
        <property type="gene ID" value="B456_008G219800"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105764938"/>
    <dbReference type="eggNOG" id="KOG1285">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="KTEECWY"/>
    <dbReference type="OrthoDB" id="1069523at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000593578">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009570">
        <property type="term" value="C:chloroplast stroma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010436">
        <property type="term" value="F:carotenoid dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016121">
        <property type="term" value="P:carotene catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="BETA-CAROTENE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543:SF46">
        <property type="entry name" value="CAROTENOID CLEAVAGE DIOXYGENASE 4, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="KJB51508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="MBA0593210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000593578"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66349" checksum="9B69708D29C8C5AD" modified="2015-04-29" version="1">MDAFSSSFLSTLTPSTKLLSPVITTTLRSTSPSPYYAPLPYISSVRIEEKPPTSTTTTKTSHPPPPQSPKAWPPPAPSYASPSVGAKKRVEPRLSTMIFNTFDDIINNFIDPPLRPSVDPKHVLSHNFAPVDELPPTPCEVIQGSLPPCLDGAYIRNGPNPQFLPRGPYHLFDGDGMLHSIRISKGKATLCSRYVKTYKYSIENQMGSPVFPNVFSGFNGLTAAATRGALSAVRILSGEFNPANGIGLANTSLALFGNRLYALGESDLPYSIRLTSKGDIQTLGRIDFDGKLFMSMTAHPKIDDDTGEAFAFRYGPVPPYLTYFHFDANGNKQPDVPIFSMTRPSFLHDFAITKKYAIFADIQIGMNPMDMIIGGGSPVGTDPAKVPRIGIIPRYAKDESEIRWFDVPGFNLIHAINAWDEDDGNAIVLLAPNILSVEHTLERMDLVHALVEKVRIDLRTGLVTRHPISARNLDFAVLNPAYVAKKNKYVYAAVGDPMPKIAGVVKLDVSKGERQECTVGSRMYGPGCFGGEPFFVAKEPQNPEADEDDGYVVSYVHNENTGESRFLVMDAQSPNLDIVAAVKLPRRVPYGFHGLFVRESDLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RKN1</accession>
    <name>A0A0D2RKN1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">B456_003G113900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Removes the phosphate from trehalose 6-phosphate to produce free trehalose. Trehalose accumulation in plant may improve abiotic stress tolerance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="8"/>
    <dbReference type="EMBL" id="CM001742">
        <property type="protein sequence ID" value="KJB19680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RKN1"/>
    <dbReference type="STRING" id="29730.A0A0D2RKN1"/>
    <dbReference type="Gramene" id="KJB19680">
        <property type="protein sequence ID" value="KJB19680"/>
        <property type="gene ID" value="B456_003G113900"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1050">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="QPAQWAR"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000073">
        <property type="entry name" value="Trehalose 6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="TREHALOSE 6-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768:SF27">
        <property type="entry name" value="TREHALOSE-PHOSPHATE PHOSPHATASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="KJB19680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="418" mass="46887" checksum="B46F42881A9F3261" modified="2015-04-29" version="1">MDCLPNNSDNKTLKRWFFINESESNSFYSLSSDRRLDSMDLKSNHTALVLADPAPLNKSTLRVSSGLLPYSGATISQNLFLTVPTMKAGILDIRASNCLDSMESSSPPDKKSRDFNNDLESTDTDVAYRAWLHKYPSALASFDQITNPAKGKRIALFLDYDGTLSPIVDNPDSAFMSNDMRAAVKNVAQFFPTAIISGRSRDKVYEFVGLTELNYAGSHGMDIMGPVRQSFDDHSNCIRSTDNQGKEVNLFQPASEFLPMIDEVFNSLINNTKDIRGAKVENNKFCVSVHYRNVDEKDWTVVAQRVHDVIRNYPRLRLTHGRKVVEVRPVINWDKGKAVTFLLESLGLSNCEDVLPIYVGDDQTDEDAFKVLREGNCGYGILVSSVPKESNAFFSLKDPQEVMEFLKSLVVWKKTSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RLI4</accession>
    <name>A0A0D2RLI4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">B456_008G242000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RLI4"/>
    <dbReference type="STRING" id="29730.A0A0D2RLI4"/>
    <dbReference type="Gramene" id="KJB52013">
        <property type="protein sequence ID" value="KJB52013"/>
        <property type="gene ID" value="B456_008G242000"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0069">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="IPYYPFD"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009854">
        <property type="term" value="P:oxidative photosynthetic carbon pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000213">
        <property type="entry name" value="Putative 2-hydroxyacid dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF268">
        <property type="entry name" value="GLYOXYLATE_HYDROXYPYRUVATE REDUCTASE HPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0323">Glycolate pathway</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0601">Photorespiration</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="53"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="136"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="KJB52013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33523" checksum="D635B7CD2E32D1E3" modified="2015-04-29" version="1">MATVKEEALPLVLVHRPPNFHFPFKHRLQTHFRLLDSLDSDPPKSTHSFFSRHAASVRVLLCVDTIPITRDILSLLLFLQLIVGSSTGVDHIDLQECRRRSIAVTNAGKAFSPDVADLAVGLLIDVLRRVFASFQISGLGKHGAKIAKRLEPFGCAISYNSRRKKPSVPFPWFKNVYNLAVNNDVLIVCCMLTEESRHIISKDVMTALGKEGVIINVGREALIDEKELVQLLVRGELRGAGLDVFENEPDVPQELFSLKNVVLSPHCAVATPECFDALEDLITANLHAFFSSKPLQSVVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RNX6</accession>
    <name>A0A0D2RNX6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="6">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">B456_008G282000</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="6"/>
    <dbReference type="EMBL" id="CM001747">
        <property type="protein sequence ID" value="KJB52888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RNX6"/>
    <dbReference type="STRING" id="29730.A0A0D2RNX6"/>
    <dbReference type="Gramene" id="KJB52888">
        <property type="protein sequence ID" value="KJB52888"/>
        <property type="gene ID" value="B456_008G282000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105765587"/>
    <dbReference type="eggNOG" id="KOG0625">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000009">
        <property type="entry name" value="Phosphoglucomutase, cytoplasmic 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF59">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="7" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="92"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="20">
        <location>
            <begin position="264"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="21">
        <location>
            <begin position="376"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="KJB52888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="635" mass="69245" checksum="A6BE9533587B3B5F" modified="2015-04-29" version="1">MASCCNSLRLEVFFSSAFKSSKRSSNAIPIPSSSFSHLGNHRFALQSISFSVPRSPSFTIKASSSSSSPSTTIAEPEGIKITSVPTKPIEGQKTGTSGLRKKVKVFMEENYLSNWIQSLFNSLPPEDYKNGVLVLGGDGRYFNREASQIIIKIAAGNGVGKILVGREGIMSTPAVSAVIRKRKANGGFIMSASHNPGGPEYDWGIKFNYNSGQPAPESITDKIYGNTLSISEIKMAEIPDVDLSRLGVTKYGNFTVEVIDPVSDYLELMESVFDFQMIKNLLSRSDFSFAFDAMHAVTGAYAKPIFVDKLGARPDSISNGVPLEDFGHGHPDPNLTYAKDLVDTMYSENGPDFGAASDGDGDRNMILGKKFFVTPSDSVAIIAANAQAGIPYFRGGPKGLARSMPTSGALDRVAEKLGLTFFEVPTGWKFFGNLMDAGKLSICGEESFGTGSDHIREKDGIWAVLAWLSIIAYRNKDKKPGEKLVSISDVVKEHWATYGRNFFSRYDYEECESEGANKMIEYLRELISKSKAGEKYGNYVLQFADDFSYTDPVDGSVASKQGVRFVFTDGSRIIFRLSGTGSAGATVRIYIEQFEPDASKHDMDAQVALKPLIDLALSVSKLKDFTGREKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSB2</accession>
    <name>A0A0D2RSB2_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_011G240500</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001750">
        <property type="protein sequence ID" value="KJB73602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSB2"/>
    <dbReference type="STRING" id="29730.A0A0D2RSB2"/>
    <dbReference type="Gramene" id="KJB73602">
        <property type="protein sequence ID" value="KJB73602"/>
        <property type="gene ID" value="B456_011G240500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105777074"/>
    <dbReference type="eggNOG" id="KOG1235">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 11"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050154">
        <property type="entry name" value="UbiB_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566">
        <property type="entry name" value="CHAPERONE-ACTIVITY OF BC1 COMPLEX CABC1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10566:SF123">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="803"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="284"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB73602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="845" mass="95028" checksum="EFB9B18AD410354C" modified="2015-04-29" version="1">MALTTSLTASMSVTSLRESRVLKTTTYRRKQRVKQQQQPQRRVQAFFGNFSHFGDVVRRDMDFLKTGVQRGVEWANETFRIPQAKKAVDDVVWLRNLEDPNFSPPAQPPLWPQPYYPALSGMDLMMADLKALEAYVSYFYYQSKKWSKPLPEAYDAEEVTDYFSHRPHVVAFRLLEVFSSFASAAIRIRMAGLKKSLRPGSSKDIDENLSQYNFGMVLKETMLSLGPTFIKVGQSLSTRPDIIGPEISKALSELHDQIPPFPRPLAVKIIEEELGSPIGSFFSYISEEPVAAASFGQVYRGCTLDGSDVAVKVQRPNLRHVVVRDVYILRLGLGLLQKIAKRKSDPRLYADELGKGLVGELDYTLEAANASQFLDAHSHFSFMQVPKVFQHLTRKRVLTMEWMVGESSTDLLSITTSSSIKHGSKYLERQKVDAKRRLLDLVNKGVEASLTQLLETGMLHADPHPGNLRYTASGRIGFLDFGLLCRMEKKHQFAMLASIVHIVNGDWSSLLQALTEMDVVRPGTNIRRVTMDLEDALGEVELKDGIPDIKFSRVLGKIWSVALKYHFRMPPYYTLVLRSLASLEGLAVAADPSFKTFEAAYPFVVRKLLTENSAETRKILHSVVLNRKKEFRWERLALFMRVGATGRSLQLVEASSGETSLDNLPSRTDGVFDVAYLLLRLLPSKDGVVLRRLIMTADGASLVRAAVSKEAKAFRFQLCKIIADILYQRMVKALGQLVPVSQYSYKLRLAGGQQNTELHPSARLSASSTVYDYQSLLSDRRLKLILSKILNSARKEPALMLRFYWVSFVTFIAASALAFHRLLISLSAAYIGPASFIPKRFAISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RSH9</accession>
    <name>A0A0D2RSH9_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_009G021500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB54118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RSH9"/>
    <dbReference type="Gramene" id="KJB54118">
        <property type="protein sequence ID" value="KJB54118"/>
        <property type="gene ID" value="B456_009G021500"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105771077"/>
    <dbReference type="eggNOG" id="KOG4197">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="DCYVCNS"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000989">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein At1g31430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000348">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000427">
        <property type="entry name" value="Pentatricopeptide repeat-containing protein chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046848">
        <property type="entry name" value="E_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046960">
        <property type="entry name" value="PPR_At4g14850-like_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47926:SF489">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20431">
        <property type="entry name" value="E_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="6"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
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        <location>
            <begin position="97"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="167"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="198"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="330"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="431"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB54118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69561" checksum="2D6A7AE8A3E04338" modified="2015-04-29" version="1">MLLQSQLRLFHFISRHYILSKPRLFSFHSPLTKQSCISLLKSCKSMNHLKQIQAQTFLLGLHQDSHTLNKLIAFCTDPTLGTFRYAEKIFNLVQYPSLFIYNVMIKTFVKKGSHKNAILVFGKLREQGLWPDGFTYPFVFKAIGSLGAVFEGQKIHGLVAKSGLEFDAYVVNSLMDMYVQVGRIRCSKKLFDEMPQRDVVAWNVLISGLVKCGKFEDAVNLFGLMRKEGLVKPNEATIVSTLSACTALGRLDLGKEIDHYAREELELTTIMGNALLDMYCKCGCLDIARKLFDDMPSKNVNCWTSMVSGYVNVGQLAEARRLFERSPVRDVVLWTAMINGYVQFNCFDEAVGLFQEMQAQRVKPDKFVLVSLLTGCAKLGALEQGKWIHGYLNENSIVLDTVVGTALIEMYAKCGCIEEALEIFYGLRKRDTASWTSIICGMAVNGETSKALELFSEMEQTNEKPDDITFIGVLSACSHGGLVEEGRKVFDSISKVYHMEPKLEHYACLIDLLCRAGLLVEVEKLIDDIPGKDNETIVPLYGSLLSACRTYGNVEMGERMAQRLVEIQSSDSSVHTLLSNIYASADRWEDVKKVREKMKDLGVKKVPGCSSIKVNGAITQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2RUA8</accession>
    <name>A0A0D2RUA8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">B456_004G061400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
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        <property type="protein sequence ID" value="KJB22704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB22705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB22706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2RUA8"/>
    <dbReference type="STRING" id="29730.A0A0D2RUA8"/>
    <dbReference type="Gramene" id="KJB22704">
        <property type="protein sequence ID" value="KJB22704"/>
        <property type="gene ID" value="B456_004G061400"/>
    </dbReference>
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        <property type="protein sequence ID" value="KJB22705"/>
        <property type="gene ID" value="B456_004G061400"/>
    </dbReference>
    <dbReference type="Gramene" id="KJB22706">
        <property type="protein sequence ID" value="KJB22706"/>
        <property type="gene ID" value="B456_004G061400"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105790527"/>
    <dbReference type="eggNOG" id="KOG4205">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="TWRSEQD"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000102">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF16">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="106"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="KJB22705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="479" mass="50553" checksum="1918DD40AE104137" modified="2015-04-29" version="1">MSESGSKLFIGGISWGTDEDRLKEYFSSFGEVVEAVIMKDRTTGRARGFGFVVFADPAVAERVIKEKHNIDGRMVEAKKAVPRDDQNIMSRSTSSIHGSPSPGPTRKIFVGGLTSTVTESDFKKYFDQFGNIIDVVVMYDHNTQRPRGFGFITYDSEEAVDKVLLKKFHELNGKMVEVKRAVPRELSPGPSRSPLGGYNYGLNRVNNFLNGYTLGYAPSSVGGYGLGMDGKFSAVAGGRSGFSPFGAGYGISMNFEPGLNLNFGNGANFSGNMSYGQGLNPYYIGNTNRLDSPIGHDRSSGGSTSFFSSATRNLWGGNGGLNYNTNAASSGAYMGSGSGSLRGNALGNNGTNWGSSAISGQGGRDNISGNSVNFGNGNGDNNFGLGTAGYERNIGTNVVPASSYTASNGGYDISFANLPASASIYGDTTWQSSTSVRDSSGTFGYGLDSATSDVTRKSSPGFVGGYNVNKRQANRGIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S0Q6</accession>
    <name>A0A0D2S0Q6_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_012G098800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB76662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S0Q6"/>
    <dbReference type="Gramene" id="KJB76662">
        <property type="protein sequence ID" value="KJB76662"/>
        <property type="gene ID" value="B456_012G098800"/>
    </dbReference>
    <dbReference type="OMA" id="KNINYIM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB76662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="155" mass="17669" checksum="F04E8E0B4E3FECC3" modified="2015-04-29" version="1">MLRALHYANNYSHILRAYISIFSHNTTRQLDIDCVISFAIMHTQHSMKFGGVVVALDSRLFVANSWQQQQSKLVASSSDCPSSDLKNFKSPGASTTIGNEKNINYIMTELRCIRNFNHSSLILANFSNKWKSNSRHKTTCQILKPENLPYKLYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S1Q8</accession>
    <name>A0A0D2S1Q8_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Saposin A-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">B456_012G118100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001751">
        <property type="protein sequence ID" value="KJB77052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S1Q8"/>
    <dbReference type="STRING" id="29730.A0A0D2S1Q8"/>
    <dbReference type="Gramene" id="KJB77052">
        <property type="protein sequence ID" value="KJB77052"/>
        <property type="gene ID" value="B456_012G118100"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105779449"/>
    <dbReference type="eggNOG" id="KOG3160">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="YANETKH"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 12"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF78">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002251428" description="Saposin A-type domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="KJB77052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30438" checksum="73A66DC8B2BBC8F1" modified="2015-04-29" version="1">MSFSKLLSLLLLVNFIFIYQSHSSPDNNVTKAQSHIKPKKVHLSLYYESLCPYCRSFIVSQLVKVFNTDLLNIINLRLVPWGNAQYVKPNKTIICQHGEDECYLNTIHACAISIWPDPRKHFNFIYCIENQGLPIKDNQHSEGMEAVWKACSARSGMDQKLIKDCYDSGYGRKLLLQYATETDHLYPKHLYVPWVTVNNQPLYDKYEDFITYVCNAYKDKDLVRACLSNSLKVTEEKFSRSPVCYVEIRSQIQQRLHCCSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2S4B1</accession>
    <name>A0A0D2S4B1_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RIN4 pathogenic type III effector avirulence factor Avr cleavage site domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">B456_004G226600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001743">
        <property type="protein sequence ID" value="KJB26120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2S4B1"/>
    <dbReference type="STRING" id="29730.A0A0D2S4B1"/>
    <dbReference type="Gramene" id="KJB26120">
        <property type="protein sequence ID" value="KJB26120"/>
        <property type="gene ID" value="B456_004G226600"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105792363"/>
    <dbReference type="eggNOG" id="ENOG502QQ5R">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="RNEPTTH"/>
    <dbReference type="OrthoDB" id="1109067at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040387">
        <property type="entry name" value="RIN4/NOI4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008700">
        <property type="entry name" value="TypeIII_avirulence_cleave"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159:SF6">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33159">
        <property type="entry name" value="RPM1-INTERACTING PROTEIN 4 (RIN4) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05627">
        <property type="entry name" value="AvrRpt-cleavage"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="RIN4 pathogenic type III effector avirulence factor Avr cleavage site" evidence="2">
        <location>
            <begin position="190"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="KJB26120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="261" mass="29006" checksum="5F6FA06CE1A67594" modified="2015-04-29" version="1">MAQRSHVPKFGNWEGEEDVPYTAYFDKARKGRTGGKIVNPNDPQENPDLRRDYVAPNKAPPAPRTKPEADELVGDGPVRRGHERGRSRDEGDFKQYAGSPVRHDNVNRRALGDSTPTRYGREAPRQGTRPKVGSENSIEKSPLHHQARVAGRGTMASPAYEAKTLYDSSHGTPGRSKMRPNTRSDESPDEGAAVPKFGDWDENNPASADGYTHIFNKVREERNNGGKTPGMPGEQSPYRTTRNRKQANSNAKSCCLPWCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDQ6</accession>
    <name>A0A0D2SDQ6_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">B456_007G151800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDQ6"/>
    <dbReference type="STRING" id="29730.A0A0D2SDQ6"/>
    <dbReference type="Gramene" id="KJB42419">
        <property type="protein sequence ID" value="KJB42419"/>
        <property type="gene ID" value="B456_007G151800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0181">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="KJB42419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17864" checksum="4D2E302F7927A62D" modified="2015-04-29" version="1" fragment="single">VLHCLPSLFYPSHWLPHCVSSSFFCPHPLPTFPNFFPSKFLLLLLVRPSGKLVQIEHALTAVGSGQTSLGIKSANGVVIATEKKLPSILVDETSVQKIQCLTPNIGVVYSGMGLDFRVLVRKSRKQAEQYHRLYKLKVEYEKGTSEKNGNVVDHYFSHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SDV4</accession>
    <name>A0A0D2SDV4_GOSRA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">B456_007G159000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <dbReference type="EMBL" id="CM001746">
        <property type="protein sequence ID" value="KJB42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SDV4"/>
    <dbReference type="Gramene" id="KJB42464">
        <property type="protein sequence ID" value="KJB42464"/>
        <property type="gene ID" value="B456_007G159000"/>
    </dbReference>
    <dbReference type="KEGG" id="gra:105801493"/>
    <dbReference type="eggNOG" id="ENOG502S4YV">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="GWCRPRR"/>
    <dbReference type="OrthoDB" id="1022321at2759"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="KJB42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="99" mass="11556" checksum="E97AC8EB3041F2F7" modified="2015-04-29" version="1">MLKRGSITVSMIPNSTLLMGWCRGRKRVKRRRGSTVRLGNKAKRRGFWLGSRSVVQWGVMVGPLRMLKKIITEITVKEKFIEAYYMYLPLLRPQLFPLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SFL4</accession>
    <name>A0A0D2SFL4_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear transcription factor Y subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">B456_009G394400</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001748">
        <property type="protein sequence ID" value="KJB61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SFL4"/>
    <dbReference type="STRING" id="29730.A0A0D2SFL4"/>
    <dbReference type="Gramene" id="KJB61963">
        <property type="protein sequence ID" value="KJB61963"/>
        <property type="gene ID" value="B456_009G394400"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG1561">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="HTRINSQ"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 9"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="KJB61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000032304"/>
        </source>
    </evidence>
    <sequence length="248" mass="27008" checksum="4246B6A315F5CF72" modified="2015-04-29" version="1" fragment="single">INQKNHTRINSQESDCKDSGDEPMLKAVIPRQQSLQSEHGLGQPMVCAKYPYLMDQGYGVFPTFGPQISGRVMLPLNLATEDGPIYAALETKVTKARKPYLHYSRHLHAVRRPRGNGGRFLNTKSSNTGKDGMEMMKANEGQLSRLTGSQISQVLQSDSGTINSYKEPNGGSSTFSGSEVSSSMYSRGDLSKGIGGDSVSHFPCNNQRDQVSVARQIILGSSHLKLFFTTLNAIALEGVVEDAQLNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2015-04-29" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0D2SJ23</accession>
    <name>A0A0D2SJ23_GOSRA</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leucine-rich repeat-containing N-terminal plant-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">B456_013G236800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Gossypium raimondii</name>
        <name type="common">Peruvian cotton</name>
        <name type="synonym">Gossypium klotzschianum subsp. raimondii</name>
        <dbReference type="NCBI Taxonomy" id="29730"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Viridiplantae</taxon>
            <taxon>Streptophyta</taxon>
            <taxon>Embryophyta</taxon>
            <taxon>Tracheophyta</taxon>
            <taxon>Spermatophyta</taxon>
            <taxon>Magnoliopsida</taxon>
            <taxon>eudicotyledons</taxon>
            <taxon>Gunneridae</taxon>
            <taxon>Pentapetalae</taxon>
            <taxon>rosids</taxon>
            <taxon>malvids</taxon>
            <taxon>Malvales</taxon>
            <taxon>Malvaceae</taxon>
            <taxon>Malvoideae</taxon>
            <taxon>Gossypium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2012" name="Nature" volume="492" first="423" last="427">
            <title>Repeated polyploidization of Gossypium genomes and the evolution of spinnable cotton fibres.</title>
            <authorList>
                <person name="Paterson A.H."/>
                <person name="Wendel J.F."/>
                <person name="Gundlach H."/>
                <person name="Guo H."/>
                <person name="Jenkins J."/>
                <person name="Jin D."/>
                <person name="Llewellyn D."/>
                <person name="Showmaker K.C."/>
                <person name="Shu S."/>
                <person name="Udall J."/>
                <person name="Yoo M.J."/>
                <person name="Byers R."/>
                <person name="Chen W."/>
                <person name="Doron-Faigenboim A."/>
                <person name="Duke M.V."/>
                <person name="Gong L."/>
                <person name="Grimwood J."/>
                <person name="Grover C."/>
                <person name="Grupp K."/>
                <person name="Hu G."/>
                <person name="Lee T.H."/>
                <person name="Li J."/>
                <person name="Lin L."/>
                <person name="Liu T."/>
                <person name="Marler B.S."/>
                <person name="Page J.T."/>
                <person name="Roberts A.W."/>
                <person name="Romanel E."/>
                <person name="Sanders W.S."/>
                <person name="Szadkowski E."/>
                <person name="Tan X."/>
                <person name="Tang H."/>
                <person name="Xu C."/>
                <person name="Wang J."/>
                <person name="Wang Z."/>
                <person name="Zhang D."/>
                <person name="Zhang L."/>
                <person name="Ashrafi H."/>
                <person name="Bedon F."/>
                <person name="Bowers J.E."/>
                <person name="Brubaker C.L."/>
                <person name="Chee P.W."/>
                <person name="Das S."/>
                <person name="Gingle A.R."/>
                <person name="Haigler C.H."/>
                <person name="Harker D."/>
                <person name="Hoffmann L.V."/>
                <person name="Hovav R."/>
                <person name="Jones D.C."/>
                <person name="Lemke C."/>
                <person name="Mansoor S."/>
                <person name="ur Rahman M."/>
                <person name="Rainville L.N."/>
                <person name="Rambani A."/>
                <person name="Reddy U.K."/>
                <person name="Rong J.K."/>
                <person name="Saranga Y."/>
                <person name="Scheffler B.E."/>
                <person name="Scheffler J.A."/>
                <person name="Stelly D.M."/>
                <person name="Triplett B.A."/>
                <person name="Van Deynze A."/>
                <person name="Vaslin M.F."/>
                <person name="Waghmare V.N."/>
                <person name="Walford S.A."/>
                <person name="Wright R.J."/>
                <person name="Zaki E.A."/>
                <person name="Zhang T."/>
                <person name="Dennis E.S."/>
                <person name="Mayer K.F."/>
                <person name="Peterson D.G."/>
                <person name="Rokhsar D.S."/>
                <person name="Wang X."/>
                <person name="Schmutz J."/>
            </authorList>
            <dbReference type="PubMed" id="23257886"/>
            <dbReference type="DOI" id="10.1038/nature11798"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RLP family.</text>
    </comment>
    <dbReference type="EMBL" id="CM001752">
        <property type="protein sequence ID" value="KJB83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0D2SJ23"/>
    <dbReference type="Gramene" id="KJB83237">
        <property type="protein sequence ID" value="KJB83237"/>
        <property type="gene ID" value="B456_013G236800"/>
    </dbReference>
    <dbReference type="eggNOG" id="KOG0619">
        <property type="taxonomic scope" value="Eukaryota"/>
    </dbReference>
    <dbReference type="OMA" id="FFGDISM"/>
    <dbReference type="Proteomes" id="UP000032304">
        <property type="component" value="Chromosome 13"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000111">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase ERECTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000095">
        <property type="entry name" value="LRR receptor-like serine/threonine-protein kinase GSO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013210">
        <property type="entry name" value="LRR_N_plant-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051502">
        <property type="entry name" value="RLP_Defense_Trigger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062:SF21">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48062">
        <property type="entry name" value="RECEPTOR-LIKE PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08263">
        <property type="entry name" value="LRRNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00019">
        <property type="entry name" value="LEURICHRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002264060" description="Leucine-rich repeat-containing N-terminal plant-type domain-containing protein" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1073"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="Leucine-rich repeat-containing N-terminal plant-type" evidence="14">
        <location>
            <begin position="28"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
     
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